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Journal articles on the topic 'Oropharyngeal squamous cell carcinoma'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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1

Marur, Shanthi, and Barbara Burtness. "Oropharyngeal squamous cell carcinoma treatment." Current Opinion in Oncology 26, no. 3 (May 2014): 252–58. http://dx.doi.org/10.1097/cco.0000000000000072.

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2

McHugh, Jonathan B. "Association of Cystic Neck Metastases and Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma." Archives of Pathology & Laboratory Medicine 133, no. 11 (November 1, 2009): 1798–803. http://dx.doi.org/10.5858/133.11.1798.

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Abstract Human papillomavirus is an established cause of oropharyngeal squamous cell carcinoma. Similar to cervical cancer, these cancers are usually caused by high-risk human papillomavirus types 16 and 18 and are associated with high-risk sexual behaviors. Human papillomavirus–associated oropharyngeal squamous cell carcinoma typically affects the palatine and lingual tonsils and frequently results in cystic neck metastases. The histopathology of this subset of head and neck squamous cell carcinoma is unique and typically characterized by poorly differentiated, nonkeratinizing morphology with a basaloid appearance. These tumors occur in younger patients and are more often seen in nonsmokers compared with conventional oral cavity and oropharyngeal squamous cell carcinomas. The incidence of human papillomavirus–associated squamous cell carcinoma is increasing. Recognition of this unique clinicopathologic subset of head and neck carcinoma is important because these patients typically respond more favorably to organ-sparing treatment modalities and have an improved prognosis.
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3

Lehn, Carlos Neutzling, Ivo Marquis Beserra, Paulo Carvalho, Adriana Silva, Marcos Carvalho, and Viviane Santos. "FAS and FASL Polymorphisms in Oral / Oropharyngeal Cancer." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (August 2008): P37. http://dx.doi.org/10.1016/j.otohns.2008.05.122.

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Objective Examine the hypothesis if genetic polymorphisms in FAS and FASL genes, alone or in combination, are associated with oral and oropharyngeal squamous-cell carcinoma. Methods Prospective study based on 225 pacients with oral and oropharyngeal squamous-cell carcinoma and 215 controls, analyzed with PCR-RFLP. Results We observed a statistically significantly increased risk of oral and oropharyngeal squamous-cell carcinoma associated with the FASL -844 CT genotype (p=0,031). An increased risk of oral and oropharyngeal squamous-cell carcinoma was also associated with the FASL −844 T allele (p=0,04). Gene-gene interactions of FAS and FASL polymorphisms increased the risk of oral and oropharyngeal squamous-cell carcinoma in a multiplicative manner (p=0,04). Conclusions The results suggest that the presence of the allele T of FASL and its combination with G allele potentially increase the risk of cancer development.
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4

Smith, Timothy J., Anthony Mendez, Carrlene Donald, and Thomas Harold Nagel. "HPV-associated oropharyngeal squamous cell carcinoma." Journal of the American Academy of Physician Assistants 30, no. 1 (January 2017): 14–19. http://dx.doi.org/10.1097/01.jaa.0000510985.76167.ed.

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5

Polatova, D. Sh, and A. Yu Madaminov. "Molecular and clinical aspects of oropharyngeal squamous cell carcinoma associated with human papillomavirus." Head and Neck Tumors (HNT) 11, no. 2 (August 8, 2021): 31–40. http://dx.doi.org/10.17650/2313-805x-2021-11-2-31-40.

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Currently, the role of human papillomavirus (HPV) in carcinogenesis is well known: more than 90 % of HPV-positive oropharyngeal squamous cell carcinomas are caused by HPV type 16 (HPV-16). HPV E6 and E7 oncoproteins play a significant role in the development of this tumor. The E6- mediated degradation of suppressor protein p53 results in G2/M-phase checkpoint dysregulation and inhibition of apoptosis. HPV oncoprotein E7 binds to pRb, promoting its degradation and the release of E2F transcription factor. Diagnostic assays for HPV detection include immunohistochemical staining for p16, polymerase chain reaction, in situ hybridization, and next-generation sequencing. Immunohistochemical examination (determination of p16 protein expression) is an economical and very specific way to detect a viral infection. Patients with HPV-positive oropharyngeal squamous cell carcinoma demonstrate significantly better response to treatment and overall survival rates than those with HPV-negative oropharyngeal squamous cell carcinoma. Despite the fact that five-year overall survival rate in patients with HPV-positive oropharyngeal squamous cell carcinoma after treatment exceeds 80 %, some patients have poor survival. Unfortunately, currently available methods of risk stratification still do not endure their timely identification. Further research is needed to address these problems.
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6

Mohamed, Hesham, Jaana Hagström, Lauri Jouhi, Timo Atula, Alhadi Almangush, Antti Mäkitie, and Caj Haglund. "The expression and prognostic value of stem cell markers Bmi-1, HESC5:3, and HES77 in human papillomavirus–positive and –negative oropharyngeal squamous cell carcinoma." Tumor Biology 41, no. 3 (March 2019): 101042831984047. http://dx.doi.org/10.1177/1010428319840473.

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Human papillomavirus is detected in over 50% of oropharyngeal squamous cell carcinomas. Human papillomavirus–positive oropharyngeal squamous cell carcinomas differ from human papillomavirus–negative tumors, and both expression patterns are classified as distinct entities. The Bmi-1 oncogene is a well-known member of the mammalian polycomb-group family. HESC5:3 and HES77 are newly developed monoclonal antibodies produced against undifferentiated embryonic stem cells. Our aim was to explore their roles in both human papillomavirus–positive and –negative oropharyngeal squamous cell carcinomas. Our cohort comprised 202 consecutive oropharyngeal squamous cell carcinoma patients diagnosed and treated with curative intent. We used tissue microarray tumor blocks to study the immunohistochemical expression of Bmi-1, HESC5:3, and HES77. We compared the expressions of these stem cell markers with p16 immunoexpression and human papillomavirus status, as well as with other characteristics of the tumor, and with patients’ clinical data and follow-up data. Human papillomavirus– and p16-positive tumors expressed less Bmi-1 and more HESC5:3 than the negative tumors. HES77 expression was high in human papillomavirus–positive oropharyngeal squamous cell carcinoma, but it did not correlate with p16 positivity. In our multivariable model, Bmi-1 and HESC5:3 were still associated with human papillomavirus, but the association between human papillomavirus and HES77 remained absent. In conclusion, Bmi-1, HESC5:3, and HES77 may have a different role in human papillomavirus–positive and human papillomavirus–negative tumors. There was no correlation between Bmi-1, HESC5:3, and HES77 expression and survival.
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7

Milovanovic, Jovica, Ana Jotic, Dragoslava Andrejic, Aleksandar Trivic, Bojan Pavlovic, Katarina Savic-Vujovic, Ana Banko, Andjela Milovanovic, and Vojko Djukic. "Prevalence of human papillomavirus in oropharyngeal squamous cell carcinoma in Serbia." Srpski arhiv za celokupno lekarstvo 146, no. 5-6 (2018): 271–78. http://dx.doi.org/10.2298/sarh1806271m.

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Introduction/Objective. Oropharyngeal carcinoma makes up to 3% of all newly diagnosed carcinomas in the world. In Serbia, oropharyngeal carcinoma constitutes 1.8% of all malignancies. Studies have shown a growing role of infections with human papilloma viruses (HPV) in oropharyngeal cancer etiology. HPV positive patients have a more favorable prognosis and significantly higher rate of overall survival. The purpose of this paper was to establish how HPV status influenced Serbian patients? overall survival and the disease-free survival according to known risk factors (tobacco and alcohol consummation), clinical TNM stage of the disease, and modality of treatment. Methods. The study included 87 patients treated for oropharyngeal carcinoma in a one-year period with a five-year follow-up. Treatment modalities included surgery with or without postoperative radio- or chemoradiotherapy, only radiotherapy or chemoradiotherapy. Sex, common risk factors, TNM stage, and treatment method were considered, as well as the influence of HPV status on the overall survival and the disease-specific survival depending on the presence of risk factors. Results. HPV-positive patients with oropharyngeal carcinoma were more frequently men, smokers, and alcohol consumers. Considering clinical T, N, and M stage of the disease, the overall survival and the disease-specific survival rates were better in HPV-positive patients, who had better survival if they were treated with primary surgical therapy rather than primary radiotherapy. Conclusion. HPV status significantly influenced survival and locoregional control in Serbian patients with oropharyngeal carcinoma. This implies possible modifications of treatment strategies for these patients in order to further improve their prognosis and treatment outcomes.
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8

Kao, S. S., and E. H. Ooi. "Survival outcomes following salvage surgery for oropharyngeal squamous cell carcinoma: systematic review." Journal of Laryngology & Otology 132, no. 4 (May 15, 2017): 299–313. http://dx.doi.org/10.1017/s0022215117000998.

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AbstractBackground:Recurrent oropharyngeal squamous cell carcinoma causes great morbidity and mortality. This systematic review analyses survival outcomes following salvage surgery for recurrent oropharyngeal squamous cell carcinoma.Methods:A comprehensive search of various electronic databases was conducted. Studies included patients with recurrent or residual oropharyngeal squamous cell carcinoma treated with salvage surgery. Primary outcomes were survival rates following salvage surgery. Secondary outcomes included time to recurrence, staging at time of recurrence, post-operative complications, and factors associated with mortality and recurrence. Methodological appraisal and data extraction were conducted as per Joanna Briggs Institute methodology.Results:Eighteen articles were included. The two- and five-year survival rates of the patients were 52 per cent and 30 per cent respectively.Conclusion:Improvements in treatment modalities for recurrent oropharyngeal squamous cell carcinoma were associated with improvements in two-year overall survival rates, with minimal change to five-year overall survival rates. Various factors were identified as being associated with long-term overall survival, thus assisting clinicians in patient counselling and selection for salvage surgery.
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9

Lewis, James S., Beth Beadle, Justin A. Bishop, Rebecca D. Chernock, Carol Colasacco, Christina Lacchetti, Joel Todd Moncur, et al. "Human Papillomavirus Testing in Head and Neck Carcinomas: Guideline From the College of American Pathologists." Archives of Pathology & Laboratory Medicine 142, no. 5 (December 18, 2017): 559–97. http://dx.doi.org/10.5858/arpa.2017-0286-cp.

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Context Human papillomavirus (HPV) is a major cause of oropharyngeal squamous cell carcinomas, and HPV (and/or surrogate marker p16) status has emerged as a prognostic marker that significantly impacts clinical management. There is no current consensus on when to test oropharyngeal squamous cell carcinomas for HPV/p16 or on which tests to choose. Objective To develop evidence-based recommendations for the testing, application, interpretation, and reporting of HPV and surrogate marker tests in head and neck carcinomas. Design The College of American Pathologists convened a panel of experts in head and neck and molecular pathology, as well as surgical, medical, and radiation oncology, to develop recommendations. A systematic review of the literature was conducted to address 6 key questions. Final recommendations were derived from strength of evidence, open comment period feedback, and expert panel consensus. Results The major recommendations include (1) testing newly diagnosed oropharyngeal squamous cell carcinoma patients for high-risk HPV, either from the primary tumor or from cervical nodal metastases, using p16 immunohistochemistry with a 70% nuclear and cytoplasmic staining cutoff, and (2) not routinely testing nonsquamous oropharyngeal carcinomas or nonoropharyngeal carcinomas for HPV. Pathologists are to report tumors as HPV positive or p16 positive. Guidelines are provided for testing cytologic samples and handling of locoregional and distant recurrence specimens. Conclusions Based on the systematic review and on expert panel consensus, high-risk HPV testing is recommended for all new oropharyngeal squamous cell carcinoma patients, but not routinely recommended for other head and neck carcinomas.
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10

Dong, Jianfeng, Lijun Cheng, Minchao Zhao, Xiangfeng Pan, Zhiqiang Feng, and Dawei Wang. "Tim-3-expressing macrophages are functionally suppressed and expanded in oral squamous cell carcinoma due to virus-induced Gal-9 expression." Tumor Biology 39, no. 5 (May 2017): 101042831770165. http://dx.doi.org/10.1177/1010428317701651.

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Oropharyngeal head and neck squamous cell carcinoma is a common malignant tumor in the oral cavity. High-risk human papillomavirus 16 infection is a major cause of oropharyngeal head and neck squamous cell carcinoma development. Strong antitumor immune responses, especially CD8+ T cell responses, are thought to be essential to effective cancer treatment and are associated with better prognosis in oropharyngeal head and neck squamous cell carcinoma. In this study, we examined the role of the Tim-3/Gal-9 pathway in oropharyngeal head and neck squamous cell carcinoma patients. We found that Gal-9 expression by CD4+ T cells was increased in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients, but not in human papillomavirus-negative oropharyngeal head and neck squamous cell carcinoma patients. Increased Gal-9 secretion by CD4+ T cells presented multiple immunosuppressive effects. Coculturing monocytes with high Gal-9-expressing CD4+ T cells resulted in the expansion of Tim-3+ monocytes, which suppressed interferon gamma production by activated CD8+ T cells. Subsequently, total monocytes incubated with exogenous Gal-9, or high Gal-9-expressing CD4+ T cells, suppressed the expression of interferon gamma by CD8+ T cells. Exogenous Gal-9 and high Gal-9-expressing CD4+ T cells also suppressed the secretion of both interleukin 10 and interleukin 12 by monocytes. These effects are Tim-3/Gal-9-dependent because blocking Tim-3 and/or Gal-9 could enhance the support of CD8+ T cell interferon gamma production and the interleukin 10 and interleukin 12 secretion by monocytes. Together, these data suggest that the high Tim-3 expression in monocytes could be utilized by tumor-promoting Gal-9 expression on CD4+ T cells. Immunotherapy in human papillomavirus-positive oropharyngeal head and neck squamous cell carcinoma patients therefore faces an additional challenge posed by Tim-3 and Gal-9 and likely requires the blockade of these molecules.
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11

Sinno, Sara, Adel M. Assaad, and Nina Salem Shabb. "Human Papillomavirus–Associated Oropharyngeal High-Grade Neuroendocrine Carcinoma in an Adolescent: Case Report and Review of Literature." Clinical Medicine Insights: Pediatrics 13 (January 2019): 117955651987052. http://dx.doi.org/10.1177/1179556519870520.

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Oropharyngeal small cell carcinomas (OPSmCC) are rare with only few case reports and case series published in the literature. More recently, an association of these tumors with human papillomavirus (HPV) infection has been detected. However, unlike oropharyngeal squamous cell carcinomas which have a better outcome when associated with HPV, OPSmCC exhibit an aggressive behavior. In this article, we report a case of tonsillar carcinoma arising in a 14-year-old boy that was associated with HPV infection. The tumor exhibited morphologic features of small cell carcinoma with no overt squamous differentiation. Yet, by immunohistochemistry, it showed diffuse and strong co-expression of both squamous and neuroendocrine markers. In addition, we present the clinicopathologic features of all the cases of OPSmCC reported in the literature for which p16 and/or HPV testing have been done.
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12

Van Abel, Kathryn M., and Eric J. Moore. "Focus Issue: Neck Dissection for Oropharyngeal Squamous Cell Carcinoma." ISRN Surgery 2012 (January 15, 2012): 1–10. http://dx.doi.org/10.5402/2012/547017.

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The staging and prognosis of oropharyngeal squamous cell carcinoma is intimately tied to the status of the cervical lymph nodes. Due to the high risk for occult nodal disease, most clinicians recommend treating the neck for these primary tumors. While there are many modalities available, surgical resection of nodal disease offers both a therapeutic and a diagnostic intervention. We review the relevant anatomy, nodal drainage patterns, clinical workup, surgical management and common complications associated with neck dissection for oropharyngeal squamous cell carcinoma.
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13

Gondim, Dikson Dibe, Wesley Haynes, Xiaowei Wang, Rebecca D. Chernock, Samir K. El-Mofty, and James S. Lewis. "Histologic Typing in Oropharyngeal Squamous Cell Carcinoma." American Journal of Surgical Pathology 40, no. 8 (August 2016): 1117–24. http://dx.doi.org/10.1097/pas.0000000000000650.

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14

Holtzman, Adam L., and Kathryn Hitchcock. "Human Papillomavirus–Associated Oropharyngeal Squamous-Cell Carcinoma." New England Journal of Medicine 375, no. 13 (September 29, 2016): 1269. http://dx.doi.org/10.1056/nejmicm1515402.

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15

Sand, Jordan P., Bruce H. Haughey, and Brian Nussenbaum. "Asymptomatic p16-Positive Oropharyngeal Squamous Cell Carcinoma." JAMA Otolaryngology–Head & Neck Surgery 140, no. 10 (October 1, 2014): 975. http://dx.doi.org/10.1001/jamaoto.2014.1944.

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16

Thomas, L., T. M. Jones, C. Katre, S. Tandon, P. Carding, D. Lowe, and S. Rogers. "Speech outcomes in oropharyngeal squamous cell carcinoma." British Journal of Oral and Maxillofacial Surgery 45, no. 8 (December 2007): e6. http://dx.doi.org/10.1016/j.bjoms.2007.08.019.

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17

Van Abel, Kathryn M., and Eric J. Moore. "Surgical Management of Oropharyngeal Squamous Cell Carcinoma." Current Otorhinolaryngology Reports 1, no. 3 (June 8, 2013): 137–44. http://dx.doi.org/10.1007/s40136-013-0021-x.

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18

Yasumatsu, R., T. Nakashima, and S. Komune. "Squamous cell carcinoma of the oropharynx: single-institution outcome analysis of patients treated with concurrent chemoradiotherapy." Journal of Laryngology & Otology 129, S2 (February 23, 2015): S77—S82. http://dx.doi.org/10.1017/s0022215114002448.

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AbstractPurpose:The object of this study was to analyse our experience with the effects of concurrent chemoradiotherapy for oropharyngeal squamous cell carcinoma, the treatment results of this therapeutic strategy and a salvage treatment for recurrent oropharyngeal squamous cell carcinoma.Methods:Seventy-five patients with oropharyngeal squamous cell carcinoma were treated with chemoradiotherapy. The study included twenty-five of these patients who had recurrent oropharyngeal squamous cell carcinoma after chemoradiotherapyResults:The three-year actuarial survival rates for 75 patients by disease stage were as follows: stage II, 100 per cent; stage III, 71.1 per cent; stage IV, 51.7 per cent and overall, 58.2 per cent. The mean time of detection of recurrence was 6.2 months. The total salvage rates of recurrence were 21 per cent. The one and three-year tumour-free actuarial survival rates of those patients who received salvage treatment were 83 and 33 per cent.Conclusions:Surgical salvage was only feasible for early recurrent tumour. Close follow-up surveillance of early recurrence is essential after primary treatment of patients with chemoradiotherapy.
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19

Queiroz, Cleberson Jean dos Santos, Cintia Mara de Amorim Gomes Nakata, and Amilcar Sabino Damazo. "Annexin A1 and HPV in oropharyngeal squamous cell carcinoma." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): e22150-e22150. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22150.

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e22150 Background: Annexin-A1 (ANXA1) is a protein involved in signal transduction and inflammation. Its expression is increased in some tumors (i.e. hepatocellular carcinomas, gliomas, pancreatic adenocarcinomas), but in head and neck tumors, its expression is usually reduced. Tumor suppressor p53 is frequently expressed in cancers due to mutation. HPV infection is strongly linked to oropharyngeal tumors. Methods: We analyzed 21 formalin-fixed paraffin-embedded samples of oropharyngeal carcinoma. Using immunofluorescence (IF), ANXA1 expression was quantified by measuring mean optical density (MOD). We also evaluated p53 positivity using IF. Presence of HPV DNA (serotypes 16/18 and 31/33) was analyzed through chromogenic in situ hybridization. Interaction between ANXA1, p53 and HPV was performed by Student's t test and ANOVA, with Bonferroni test, using the software Graph Pad Prism. Results: HPV DNA was found in 12 of 21 cases (57%). Serotypes 16/18 were found in all HPV + samples, whereas serotypes 31/33 were found in 2 of the 12. Among HPV+ cases, we noticed a decreased expression of ANXA1 in tumor compared to epithelium, independent of p53 status. With respect to HPV- cases, we have found a reduced expression of ANXA1 in the tumor versus epithelium, but the difference was only statistically significant in p53+ samples. In epithelia, we observed an increased expression of ANXA1 in HPV+ compared with HPV- samples. Conclusions: Our results confirm a decreased expression of ANXA1 in oropharyngeal carcinoma independently of HPV status, suggesting its involvement in the carcinogenesis. There was no difference in the expression of ANXA1 according to p53 status. In normal epithelia, we observed an increased expression of ANXA1 in HPV+ samples, which may suggest the involvement of the protein in the early stages of HPV-driven carcinogenesis. [Table: see text]
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20

Cleary, Ryan K., and Anthony J. Cmelak. "Evolving Treatment Paradigms for Oropharyngeal Squamous Cell Carcinoma." Journal of Global Oncology, no. 4 (December 2018): 1–9. http://dx.doi.org/10.1200/jgo.2016.006304.

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Oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence in the United States and in many countries worldwide primarily as a result of increasing rates of human papillomavirus (HPV) infection. HPV-positive OPSCC represents a distinct disease entity from head and neck squamous cell carcinoma caused by traditional risk factors such as tobacco and alcohol, with different epidemiology, patterns of failure, and expected outcomes. Because patients with HPV-positive OPSCC have a younger median age and superior prognosis compared with their HPV-negative counterparts, they live longer with the morbidity of treatment, which can be severe. Therefore, efforts are under way to de-escalate therapy in favorable-risk patients while maintaining treatment efficacy. Additional work is being undertaken to discover new therapies that may benefit both HPV-positive and HPV-negative patient subsets. Herein, we will review the available data for the evolving treatment paradigms in OPSCC as well as discuss ongoing clinical trials.
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21

Helman, Samuel N., Thomas Schwedhelm, Sameep Kadakia, Yanhua Wang, Bradley A. Schiff, and Richard V. Smith. "Transoral Robotic Surgery in Oropharyngeal Carcinoma." Archives of Pathology & Laboratory Medicine 139, no. 11 (August 19, 2015): 1389–97. http://dx.doi.org/10.5858/arpa.2014-0573-ra.

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Context The incidence of oropharyngeal squamous cell carcinoma has increased during the past decade and is related primarily to the human papillomavirus. This change in etiology, from tobacco and alcohol to human papillomavirus, has resulted in improved survival for the disease. In the United States, open resection had largely been replaced by concurrent chemotherapy and/or radiotherapy by the early 2000s. The advent of transoral surgery has led to an increase in surgery as the primary treatment for both early- and advanced-stage oropharyngeal squamous cell carcinoma because it has potential advantages over open surgery and nonsurgical modalities. Objective To provide an overview of transoral robotic surgery for oropharyngeal squamous cell carcinoma and contrast it with other surgical and nonsurgical modalities. Data Sources Articles from 2000 to 2014 were accessioned on PubMed and reviewed for utility by the primary authors. Conclusions Transoral surgery has become more commonly used as a minimally invasive approach to treat oropharyngeal tumors. Other strategies, including radiation, chemotherapy with radiation, and open surgery, are still important treatment approaches. The treatment options for an individual patient rely on multiple factors, including the tumor location and size, features of the tumor, and patient comorbidities. The continued study of these techniques is important to match the patient with the most appropriate treatment.
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Tan, Marietta, Jeffrey N. Myers, and Nishant Agrawal. "Oral Cavity and Oropharyngeal Squamous Cell Carcinoma Genomics." Otolaryngologic Clinics of North America 46, no. 4 (August 2013): 545–66. http://dx.doi.org/10.1016/j.otc.2013.04.001.

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CAMPION, ANNA CAROLINA OMENA VASCONCELLOS LE, CAMILA MARIA BEDER RIBEIRO, HERBERT CHARLES SILVA BARROS, KARINE DE CáSSIA BATISTA DOS SANTOS, ALINE CACHATE DE FARIAS, STEFâNIA JERôNIMO FERREIRA, and SONIA MARIA SOARES FERREIRA. "PROGNOSIS OF ORAL AND OROPHARYNGEAL SQUAMOUS CELL CARCINOMA." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 130, no. 3 (September 2020): e261. http://dx.doi.org/10.1016/j.oooo.2020.04.697.

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Dalianis, Tina. "Human papillomavirus (HPV) and oropharyngeal squamous cell carcinoma." La Presse Médicale 43, no. 12 (December 2014): e429-e434. http://dx.doi.org/10.1016/j.lpm.2014.08.010.

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Schmitt, Nicole C., and Umamaheswar Duvvuri. "Transoral robotic surgery for oropharyngeal squamous cell carcinoma." Current Opinion in Otolaryngology & Head and Neck Surgery 23, no. 2 (April 2015): 127–31. http://dx.doi.org/10.1097/moo.0000000000000136.

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Koch, Wayne. "Dysphagia in oropharyngeal squamous cell carcinoma in perspective." Cancer 123, no. 16 (May 3, 2017): 3003–4. http://dx.doi.org/10.1002/cncr.30710.

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Röösli, Christof, Gabriela Studer, and Sandro J. Stoeckli. "Salvage treatment for recurrent oropharyngeal squamous cell carcinoma." Head & Neck 32, no. 8 (December 1, 2009): 989–96. http://dx.doi.org/10.1002/hed.21273.

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Zenga, Joseph, Michael Wilson, Douglas R. Adkins, Hiram A. Gay, Bruce H. Haughey, Dorina Kallogjeri, Loren S. Michel, et al. "Treatment Outcomes for T4 Oropharyngeal Squamous Cell Carcinoma." JAMA Otolaryngology–Head & Neck Surgery 141, no. 12 (December 1, 2015): 1118. http://dx.doi.org/10.1001/jamaoto.2015.0764.

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Van Abel, Kathryn M., Eric J. Moore, Daniel L. Price, Michael Oldenburg, Jan L. Kasperbauer, and Kerry D. Olsen. "T4 Oropharyngeal Squamous Cell Carcinoma: Primary Management Outcomes." Otolaryngology–Head and Neck Surgery 149, no. 2_suppl (August 23, 2013): P79—P80. http://dx.doi.org/10.1177/0194599813495815a138.

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Ben Salah, Khaled, Asterios Triantafyllou, Andrew Schache, Richard Shaw, and Janet M. Risk. "Metabolic organization in HPV+ oropharyngeal squamous cell carcinoma." European Journal of Surgical Oncology 43, no. 11 (November 2017): 2208. http://dx.doi.org/10.1016/j.ejso.2017.10.090.

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Ben Salah, Khaled, Asterios Triantafyllou, Andrew Schache, Richard Shaw, and Janet M. Risk. "Metabolic organization in HPV+ oropharyngeal squamous cell carcinoma." European Journal of Surgical Oncology 44 (March 2018): S8. http://dx.doi.org/10.1016/j.ejso.2018.01.487.

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32

Kang, Stephen Y., and Enver Ozer. "Primary Surgical Management of Oropharyngeal Squamous Cell Carcinoma." Current Otorhinolaryngology Reports 3, no. 2 (April 9, 2015): 79–86. http://dx.doi.org/10.1007/s40136-015-0082-0.

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33

Paterson, A. J., and P. J. Lamey. "Oropharyngeal squamous cell carcinoma presenting as glossopharyngeal neuralgia." British Journal of Oral and Maxillofacial Surgery 30, no. 4 (August 1992): 278–79. http://dx.doi.org/10.1016/0266-4356(92)90280-v.

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Terada, Tomonori, Kota Kida, Nobuhiro Uwa, Toshimitsu Sugawa, Kenzo Tsuzuki, and Masafumi Sakagami. "Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma." Practica Oto-Rhino-Laryngologica 114, no. 3 (2021): 180–81. http://dx.doi.org/10.5631/jibirin.114.180.

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Vidhyadharan, Sivakumar, Krishnakumar Thankappan, Narayana Subramaniam, Janarthanan Ramu, Arya Ajith, Deepak Balasubramanian, and Subramania Iyer. "Robot-Assisted Surgery Avoids Mandibulotomy in a Case of Adenoid Cystic Carcinoma of Base of the Tongue." Craniomaxillofacial Trauma & Reconstruction 12, no. 2 (June 2019): 163–66. http://dx.doi.org/10.1055/s-0039-1683410.

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Surgical management is increasingly preferred in human papilloma–related oropharyngeal squamous cell carcinoma. Robotic surgery has a different role to play in oropharyngeal salivary origin tumors, where surgery is the primary essential modality. This modality may be used for better access to the oropharynx, avoiding a lip split approach with mandibulotomy. The organ preservation approach such as in oropharyngeal squamous cell carcinoma, with nonsurgical modalities like chemoradiotherapy, is not preferred in such cancers, as in the present case. In this context, robot-assisted surgery helps in reducing the morbidity by avoiding the mandibulotomy.
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36

Miller, Daniel L., Michael D. Puricelli, and M. Sharon Stack. "Virology and molecular pathogenesis of HPV (human papillomavirus)associated oropharyngeal squamous cell carcinoma." Biochemical Journal 443, no. 2 (March 27, 2012): 339–53. http://dx.doi.org/10.1042/bj20112017.

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The current literature fully supports HPV (human papillomavirus)-associated OPSCC (oropharyngeal squamous cell carcinoma) as a unique clinical entity. It affects an unambiguous patient population with defined risk factors, has a genetic expression pattern more similar to cervical squamous cell carcinoma than non-HPV-associated HNSCC (head and neck squamous cell carcinoma), and may warrant divergent clinical management compared with HNSCC associated with traditional risk factors. However, a detailed understanding of the molecular mechanisms driving these differences and the ability to exploit this knowledge to improve clinical management of OPSCC has not yet come to fruition. The present review summarizes the aetiology of HPV-positive (HPV+) OPSCC and provides a detailed overview of HPV virology and molecular pathogenesis relevant to infection of oropharyngeal tissues. Methods of detection and differential gene expression analyses are also summarized. Future research into mechanisms that mediate tropism of HPV to oropharyngeal tissues, improved detection strategies and the pathophysiological significance of altered gene and microRNA expression profiles is warranted.
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37

Ukpo, Odey C., Cedric V. Pritchett, Jean E. Lewis, Amy L. Weaver, David I. Smith, and Eric J. Moore. "Human Papillomavirus—Associated Oropharyngeal Squamous Cell Carcinomas: Primary Tumor Burden and Survival in Surgical Patients." Annals of Otology, Rhinology & Laryngology 118, no. 5 (May 2009): 368–73. http://dx.doi.org/10.1177/000348940911800509.

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Objectives: We sought to determine whether the primary tumor burden in oropharyngeal squamous cell carcinoma is lower in tumors positive for human papillomavirus (HPV) or in tumors with a smoking- or alcohol-related cause. Methods: We retrospectively reviewed medical records of patients at our institution who had squamous cell carcinoma of the palatine tonsils, base of tongue, soft palate, or pharynx from 1995 through 2006. The patients underwent primary surgical therapy. The main outcome measures were the HPV status of tumors and nodes and the survival rates (categorized by HPV status). Results: Of 102 treated patients, 48 (47.1%) had HPV-positive carcinomas. Primary tumor size was not significantly different between HPV-positive and HPV-negative tumors (median, 2.5 versus 2.0 cm; p = 0.43). Patients with HPV had a higher prevalence of neck nodal metastases (35% versus 11%; p = 0.003) and high-grade lesions (83% versus 64%; p = 0.03). Conclusions: Primary tumor burden was not associated with HPV status. Patients with HPV-positive oropharyngeal squamous cell carcinomas had a higher prevalence of neck nodal metastases and high-grade lesions.
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38

Corbett, J., D. Wilke, J. Trites, and N. Lamond. "Orbital mass as first presentation of metastatic p16-positive oropharyngeal squamous cell carcinoma." Current Oncology 24, no. 6 (December 20, 2017): 551. http://dx.doi.org/10.3747/co.24.3523.

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We describe a case in which a 67-year-old man was diagnosed with a metastatic recurrence of p16-positive oropharyngeal squamous cell carcinoma after presenting with a medial orbital mass in the region of the nasolacrimal apparatus. A review of the literature revealed that metastasis to the orbit from any malignancy is an uncommon occurrence, and no cases of p16-positive oropharyngeal squamous cell carcinoma have previously been reported. Our case highlights the importance of maintaining a high index of suspicion during surveillance visits with such patients.
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39

Kao, S. S., J. Micklem, E. Ofo, S. Edwards, D. Dhatrak, A. Foreman, S. Krishnan, and J.-C. Hodge. "A comparison of oncological outcomes between transoral surgical and non-surgical treatment protocols in the management of oropharyngeal squamous cell carcinoma." Journal of Laryngology & Otology 132, no. 4 (May 8, 2017): 349–55. http://dx.doi.org/10.1017/s0022215117000986.

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AbstractBackground:The incidence of oropharyngeal squamous cell carcinoma in the Western world is increasing, with the human papillomavirus epidemic implicated in this observed trend. The optimal treatment modality is yet undetermined regarding oncological outcomes.Methods:This study comprised 98 patients with oropharyngeal squamous cell carcinoma, treated with either primary transoral surgery with adjuvant therapy or primary chemoradiotherapy with curative intent, between 2008 and 2012. Clinicopathological characteristics including tumour–node–metastasis stage, human papillomavirus status, treatment modality, recurrence and overall survival were collated.Results:Five per cent of primary surgical patients had locoregional recurrences compared with 25 per cent of primary chemoradiotherapy patients. A lower rate of locoregional recurrence was observed in the human papillomavirus positive group.Conclusion:This paper reports higher rates of overall survival and local control for oropharyngeal squamous cell carcinoma treated with primary surgery compared with primary chemoradiotherapy. This reflects overall lower tumour stage and higher human papillomavirus status in this group.
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40

Liao, Ying-Ting, Hung-Ding Tseng, Peter Chang, Pen-Yuan Chu, Ying-Ju Kuo, and Chun-Yu Liu. "Second Primary Spindle Cell Carcinoma of Oral Cavity and Oropharynx: A Case Report and Literature Review." Reports 1, no. 2 (September 12, 2018): 16. http://dx.doi.org/10.3390/reports1020016.

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Spindle cell squamous cell carcinoma (SpCC) is a poorly differentiated subtype of squamous cell carcinoma (SqCC). We report a case with second primary oropharyngeal SpCC after seven years of complete treatment of SqCC. The patient underwent surgery and adjuvant chemoradiotherapy. Relevant literature about SpCC was reviewed.
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Megwalu, Uchechukwu C., and Brian A. Nuyen. "Survival Outcomes in Oropharyngeal Small-Cell Carcinoma Compared With Squamous Cell Carcinoma." JAMA Otolaryngology–Head & Neck Surgery 143, no. 7 (July 1, 2017): 734. http://dx.doi.org/10.1001/jamaoto.2017.0025.

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42

Gnagi, Sharon H., Forrest T. Gnagi, Scott A. Schraff, and Michael L. Hinni. "Human Papillomavirus Vaccination Counseling in Pediatric Training." Otolaryngology–Head and Neck Surgery 155, no. 1 (March 29, 2016): 87–93. http://dx.doi.org/10.1177/0194599816639932.

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Objective Demonstrate the need for increased education regarding otolaryngology-related manifestations of human papillomavirus (HPV). Highlight a need to incorporate otolaryngology-related manifestations of HPV in vaccine counseling. Study Design Survey. Setting Tertiary care academic children’s hospital. Subjects Pediatric residents, fellows, and staff. Methods An online survey was made available regarding HPV education and vaccination. Results Participants (N = 348) initiated the survey representing 28.4%, 25.6%, and 19.0% postgraduate year 1, 2, and 3 residents, respectively, as well as 17.5% chief residents/fellows and 9.5% attendings. Participants rated their prior education as none or fair regarding recurrent respiratory papillomatosis (63.8%) and oropharyngeal squamous cell carcinoma (68.3%). In contrast, 60.6% and 70.9% rated their education on genital warts and cervical cancer correspondingly as good or excellent. When asked what was routinely discussed during HPV vaccine counseling, 63.3% reported “never” discussing recurrent respiratory papillomatosis and 52.9% “never” discussing oropharyngeal squamous cell carcinoma. A range from 92.7% to 95.5% responded that there was a need for increased education regarding HPV and its role in recurrent respiratory papillomatosis and oropharyngeal squamous cell carcinoma. Conclusions Increased education about HPV and its otolaryngology-related manifestations should be undertaken to increase provider, patient, and parent awareness of recurrent respiratory papillomatosis and oropharyngeal squamous cell carcinoma. We propose that discussing the risks of otolaryngology-related disease be routinely included in HPV vaccination counseling.
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Vu, Trang T., Laura Soong, Tawny Hung, Loretta Fiorillo, and Kurian Joseph. "Cutaneous HPV16 and p16 Positive Basaloid Squamous Cell Carcinoma with Brain Metastasis: A Case Report." SAGE Open Medical Case Reports 8 (January 2020): 2050313X2093526. http://dx.doi.org/10.1177/2050313x20935260.

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Basaloid squamous cell carcinoma is an infiltrative and aggressive variant of squamous cell carcinoma with basaloid features. Primary skin-derived basaloid squamous cell carcinoma is rare. Basaloid squamous cell carcinoma is commonly observed in the oropharyngeal and anogenital regions and is associated with high-risk human papillomavirus. We report a case of primary basaloid squamous cell carcinoma overlying the right scapula with metastasis to the regional lymph nodes and brain despite surgical resection and adjuvant chemoradiation. Histopathologic investigations of high-risk cutaneous squamous cell carcinoma do not routinely involve human papillomavirus testing. In contrast, oncogenic human papillomavirus and p16 are screened in head and neck squamous cell carcinoma for prognostication. Since the patient presented with an aggressive variant of squamous cell carcinoma and distal metastasis despite standard therapies, human papillomavirus testing was performed. P16, a surrogate marker for human papillomavirus infection and specifically HPV16 was identified in the tumor. This is a unique report of HPV16 in primary cutaneous basaloid squamous cell carcinoma with distal brain metastasis.
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Economopoulou, Panagiota, Ioannis Kotsantis, and Amanda Psyrri. "De-Escalating Strategies in HPV-Associated Head and Neck Squamous Cell Carcinoma." Viruses 13, no. 9 (September 8, 2021): 1787. http://dx.doi.org/10.3390/v13091787.

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HPV-related head and neck squamous cell carcinoma (HNSCC) has emerged as a diverse clinical and biological disease entity, mainly in young patients with oropharyngeal tumors who are nonsmokers and nondrinkers. Indeed, during the past few years, the pendulum has shifted towards a new epidemiological reality, the “HPV pandemic”, where the majority of oropharyngeal squamous cell carcinomas (OPSCCs) are attributed to HPV. The oncogenic potential of the virus is associated to its capacity of integrating oncogenes E6 and E7 into the host cell, leading to the inactivation of several tumor suppressor genes, such as Rb. HPV status can affect prognosis in OPSCC, but its role as a predictive biomarker remains to be elucidated. Given the favorable prognosis associated with HPV-positive disease, the concept of de-escalation treatment strategies has been developed with the primary intent being the reduction of treatment-related long-term toxicities. In this review, we aim to depict current data regarding treatment de-escalation in HPV-associated OPSCC and discuss ongoing clinical trials.
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Gołąbek, Karolina, Krzysztof Biernacki, Jadwiga Gaździcka, Joanna K. Strzelczyk, Katarzyna Miśkiewicz-Orczyk, Łukasz Krakowczyk, Natalia Zięba, Paweł Kiczmer, Zofia Ostrowska, and Maciej Misiołek. "Selected E2F2 Polymorphisms in Oral and Oropharyngeal Squamous Cell Carcinoma." BioMed Research International 2021 (March 30, 2021): 1–7. http://dx.doi.org/10.1155/2021/8098130.

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Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) are subgroups of head and neck squamous cell carcinoma. E2F Transcription Factor 2 (E2F2) could contribute to cancer development, because it plays a critical role in many cellular processes, including the cell cycle, proliferation, differentiation, DNA damage response, and cell death. In the current study, we assessed the associations of five E2F2 polymorphisms (rs6667575, rs3218121, rs3218211, rs3218148, and rs3218203) with OSCC and OPSCC and influence on the TNM staging and grading. This is the first such survey to concern the European population. The study included 94 primary tumour samples following surgical resection from patients, whereas the control group consisted of 99 healthy individuals. We tried a matching of cases and controls for age and sample size. DNA samples were genotyped by employing the 5 ′ nuclease assay for allelic discrimination. Our results suggested that the most significant difference between the control group and the cancer group was the A/G heterozygote for rs3218121. Samples containing this genotype were mostly found in the control group. In our samples, rs6667575, rs3218121, rs3218211, and rs3218148 polymorphisms may affect the course of OSCC and OPSCC, while rs3218203 was not associated with OSCC and OPSCC. However, further studies are warranted to confirm our findings.
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46

Chi, Angela C., Terry A. Day, and Brad W. Neville. "Oral cavity and oropharyngeal squamous cell carcinoma-an update." CA: A Cancer Journal for Clinicians 65, no. 5 (July 27, 2015): 401–21. http://dx.doi.org/10.3322/caac.21293.

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47

Fauzi, Fatin Hazwani, Nurul Izzati Hamzan, Nurhayu Ab Rahman, Siti Suraiya, and Suharni Mohamad. "Detection of human papillomavirus in oropharyngeal squamous cell carcinoma." Journal of Zhejiang University-SCIENCE B 21, no. 12 (December 2020): 961–76. http://dx.doi.org/10.1631/jzus.b2000161.

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Ebisumoto, Koji, Kenji Okami, Akihiro Sakai, Taku Atsumi, Daisuke Maki, Ryosuke Sugimoto, and Masahiro Iida. "Clinical outcome of patients with oropharyngeal squamous cell carcinoma." Toukeibu Gan 37, no. 3 (2011): 405–10. http://dx.doi.org/10.5981/jjhnc.37.405.

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MIKAMI, Yasukazu, Mamoru TSUKUDA, Izumi MOCHIMATSU, Yasuhiro ARAI, Satoshi KAWAI, and Hiroyuki ENOMOTO. "CLINICAL OUTCOME OF PATIENTS WITH OROPHARYNGEAL SQUAMOUS CELL CARCINOMA." Japanese jornal of Head and Neck Cancer 27, no. 1 (2001): 85–90. http://dx.doi.org/10.5981/jjhnc1974.27.85.

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Zhang, Zhaocheng, Raj S. Mitra, Bradley S. Henson, Nabanita S. Datta, Laurie K. McCauley, Pawan Kumar, Julia S. J. Lee, Thomas E. Carey, and Nisha J. D'Silva. "Rap1GAP Inhibits Tumor Growth in Oropharyngeal Squamous Cell Carcinoma." American Journal of Pathology 168, no. 2 (February 2006): 585–96. http://dx.doi.org/10.2353/ajpath.2006.050132.

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