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Relevant bibliographies by topics / Orotic acid

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Academic literature on the topic 'Orotic acid'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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Journal articles on the topic "Orotic acid"

1

Haines, D. S. Milton, Margaret Wu, and Sonya D. Tokmakjian. "Dietary orotic acid accentuates the hepatic response to phenobarbital in rats." Biochemistry and Cell Biology 68, no. 9 (1990): 1146–49. http://dx.doi.org/10.1139/o90-171.

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In rats treated with phenobarbital for 3 days and simultaneously fed a semisynthetic diet containing 1.0% orotic acid, the extent of the increases in liver microsomal phosphatidylcholine, phosphatidylethanolamine, total RNA, total protein, and cytochrome P-450 were significantly greater than they were in rats treated identically with phenobarbital but without dietary orotic acid. This is attributed primarily to the stimulation of hepatic phosphatidylcholine synthesis by dietary orotic acid. In the absence of phenobarbital, orotic acid was shown to cause some increase in liver smooth endoplasmi

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2

Gerhardt, Valeska, Maya Tutughamiarso, and Michael Bolte. "Conformational studies of hydantoin-5-acetic acid and orotic acid." Acta Crystallographica Section C Crystal Structure Communications 68, no. 2 (2012): o92—o98. http://dx.doi.org/10.1107/s0108270112001151.

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Hydantoin-5-acetic acid [2-(2,5-dioxoimidazolidin-4-yl)acetic acid] and orotic acid (2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid) each contain one rigid acceptor–donor–acceptor hydrogen-bonding site and a flexible side chain, which can adopt different conformations. Since both compounds may be used as coformers for supramolecular complexes, they have been crystallized in order to examine their conformational preferences, giving solvent-free hydantoin-5-acetic acid, C5H6N2O4, (I), and three crystals containing orotic acid, namely, orotic acid dimethyl sulfoxide monosolvate, C5H4N2O

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3

Indy, Harvey E., and David C. Woollar. "Determination of Orotic Acid, Uric Acid, and Creatinine in Milk by Liquid Chromatography." Journal of AOAC INTERNATIONAL 87, no. 1 (2004): 116–22. http://dx.doi.org/10.1093/jaoac/87.1.116.

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Abstract A simultaneous determination of orotic acid, uric acid, and creatinine in milk is described. Following deproteinization, the sample was analyzed by reversed-phase liquid chromatography, using a highly aqueous cationic ion-pair eluent and photodiode array UV detection. In view of their potential dietary significance, the validated method was applied to survey the influence of species, season, and lactation on their contribution to the nonprotein nitrogen pool in milk. Mature bovine milk contained orotic acid, uric acid, and creatinine in the range of 30–70, 9–24, and 6–12 μg/mL, respec

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Shimamoto, Saki, Kiriko Nakamura, Shozo Tomonaga, Satoru Furukawa, Akira Ohtsuka, and Daichi Ijiri. "Effects of Cyclic High Ambient Temperature and Dietary Supplementation of Orotic Acid, a Pyrimidine Precursor, on Plasma and Muscle Metabolites in Broiler Chickens." Metabolites 10, no. 5 (2020): 189. http://dx.doi.org/10.3390/metabo10050189.

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The aim of this study was to evaluate the effects of high ambient temperature (HT) and orotic acid supplementation on the plasma and muscle metabolomic profiles in broiler chickens. Thirty-two 14-day-old broiler chickens were divided into four treatment groups that were fed diets with or without 0.7% orotic acid under thermoneutral (25 ± 1 °C) or cyclic HT (35 ± 1 °C for 8 h/day) conditions for 2 weeks. The chickens exposed to HT had higher plasma malondialdehyde concentrations, suggesting an increase in lipid peroxidation, which is alleviated by orotic acid supplementation. The HT environment

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5

Salač, Jan, Jana Šerá, Martin Jurča, Vincent Verney, Adam A. Marek, and Marek Koutný. "Photodegradation and Biodegradation of Poly(Lactic) Acid Containing Orotic Acid as a Nucleation Agent." Materials 12, no. 3 (2019): 481. http://dx.doi.org/10.3390/ma12030481.

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Orotic acid is a natural heterocyclic compound that acts as a nucleation agent in poly(lactic acid) (PLA). PLA materials with increasing orotic acid content were prepared and characterized. It was found that crystallinity of about 28% was reached with 0.3% content of the agent. Further enhancement in the content of the agent did not provoke any additional significant increase of crystallinity. Subsequently, it was investigated whether the orotic acid content affected photodegradation of PLA and, in the next phase, its biodegradation. The results of rheological measurements showed that the comp

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6

Gao, Peng, Davide Masato, Animesh Kundu, and John P. Coulter. "An Investigation on the Efficacy of Orotic Acid as a Bio-Nucleating Agent for Poly-Lactic Acid under Quiescent Condition and Injection Molding." Micromachines 13, no. 12 (2022): 2186. http://dx.doi.org/10.3390/mi13122186.

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Polylactic acid (PLA) is a bio-based biodegradable polymer and is considered to be an environmentally friendly alternative to petroleum-based polymers for various applications. Neat PLA requires an extended period at elevated temperatures to attain its maximum crystallinity, which can be mitigated by the addition of nucleating agents. Orotic acid is a natural heterocyclic nucleating agent in PLA. The effect of orotic acid on the crystallization behavior of a commercial, high-purity PLA was studied in detail. A differential scanning calorimetry (DSC) technique was utilized for this purpose. A n

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7

Motyl, T., A. Orzechowski, and Wanda Kukulska. "Urinary Orotic Acid Excretion in Hyperammonaemic Sheep; II. Renal Clearance of Orotic Acid." Journal of Veterinary Medicine Series A 35, no. 1-10 (1988): 232–35. http://dx.doi.org/10.1111/j.1439-0442.1988.tb00028.x.

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Beltyukova, S. V., O. I. Teslyuk, and E. O. Liventsova. "SORPTION-LUMINESCENT DETERMINATION OF OROTIC ACID IN MEDICINAL DRUGS." Odesa National University Herald. Chemistry 26, no. 1(77) (2021): 65–73. http://dx.doi.org/10.18524/2304-0947.2021.1(77).226138.

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Luminescent properties of orotic acid (vitamin B13), known bioactive substance, have been evaluated in this research. It has been shown that inside a coordination complex of orotic acid with terbium (III) an intermollecular excitation energy transfer from a ligand to a lanthanide ion occurs which causes sensitization of terbium (III) ion luminescence. Intensity of the terbium (III) ion luminescence (ILum) increases in the presence of anionic and cationic surfaceactive agents as a result of displacement of water molecules from coordination sphere of the complex. As a consequence of this process

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9

McCann, M. T., M. M. Thompson, I. C. Gueron, and M. Tuchman. "Quantification of orotic acid in dried filter-paper urine samples by stable isotope dilution." Clinical Chemistry 41, no. 5 (1995): 739–43. http://dx.doi.org/10.1093/clinchem/41.5.739.

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Abstract A rapid, sensitive, and specific method for quantification of orotic acid from dried filter-paper urine samples is described. The method involves stable isotope dilution with 1,3-[15N2]orotic acid analysis by gas chromatography-mass spectrometry. The assay is sufficiently sensitive to be used with solvent extraction techniques commonly used for urinary organic acid analysis. Extraction efficiencies of both native and isotopic orotic acid from dried filter paper and from water were 31% and 28%, respectively. The concentration of orotic acid in dried filter-paper urine specimens from 50

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10

Visek, W. J., and J. D. Shoemaker. "Orotic acid, arginine, and hepatotoxicity." Journal of the American College of Nutrition 5, no. 2 (1986): 153–66. http://dx.doi.org/10.1080/07315724.1986.10720122.

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Dissertations / Theses on the topic "Orotic acid"

1

Yusuf, Aroon. "Induction of resistance to the mitoinhibitory effects of orotic acid during hepatocarcinogenesis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0017/NQ45736.pdf.

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Compri, Jéssica de Cássia Zaghi. "Nanocristais de ácido orótico: preparação e caracterização físico-química." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-30032016-143022/.

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A malária é uma doença infecciosa aguda ou crônica causada por parasitas do gênero Plasmodium. Estima-se a ocorrência de 110 milhões de novos casos ao ano e cerca de um a dois milhões de óbitos em todo o mundo como decorrência da infecção. O ácido orótico ou vitamina B13 possui baixa solubilidade em praticamente todos os solventes, tal característica limita seu uso em preparações farmacêuticas. Quanto ao seu mecanismo de ação, o composto demonstrou atividade na inibição da diidroorotase e da diidroorotato desidrogenase, enzimas utilizadas no ciclo de replicação da malária, e também em outras e

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3

Carvalho, Nuno Duarte Fernandes Lima de. "BEORA - Biotechnology exploitation of orotic acid production." Doctoral thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/107901.

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Carvalho, Nuno Duarte Fernandes Lima de. "BEORA - Biotechnology exploitation of orotic acid production." Tese, 2017. https://repositorio-aberto.up.pt/handle/10216/107901.

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5

Kumar, Vineet. "Crystal engineering of multicomponent solids of pharmaceutically important molecules (Orotic acid, isoorotc acid,nsaids and sulfa drugs) with pyridine and aminopyridine based coformers." Thesis, 2018. http://localhost:8080/iit/handle/2074/7548.

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El-Sayed, Mohamed. "Cell-specific phytohormone responses mapped by the COLORFUL-biosensors during plant-microbe interactions." Doctoral thesis, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-1455-5.

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Books on the topic "Orotic acid"

1

International Symposium on Orotic Acid and Magnesiumorotate (1991 Rüdesheim, Hesse, Germany). Orotic acid in cardiology. Georg Thieme Verlag ; New York : Thieme Medical Publishers, 1992.

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2

Motyl, Tomasz. Synteza kwasu orotowego w wątrobie oraz jego wydalanie u zwierząt przeżuwających. Wydawn. SGGW-AR, 1987.

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3

Mutikainen, Ilpo. X-ray structural studies on metal complexes of uracil and orotic acid: A survey of coordination induced changes in the uracil fragment. Suomalainen Tiedeakatemia, 1988.

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4

Sheikh, Aisha. Studies on the mitoinhibitory effects of orotic acid on normal rat liver and hepatic nodules. National Library of Canada = Bibliothèque nationale du Canada, 1993.

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5

Reutter, Werner, and Alois Cihák. Orotic Acid. M.T.P. Press Limited, 2011.

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6

Williams, John F. Orotic Acid in Cardiology: International Symposium on Orotic Acid and Magnesiumorotate, November 1991, Ruedesheim/Rhine. Thieme Publishing Group, 1992.

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7

Cihák, A., and W. Reutter. Orotic Acid: Synthesis, Biochemical Aspects and Physiological Role. Springer, 2012.

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8

Laconi, Ezio. Studies on rat liver tumor promotion by orotic acid. 1988.

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9

Yusuf, Aroon. Induction of resistance to the mitoinhibitory effects of orotic acid during hepatocarcinogenesis. 1999.

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10

Vasudevan, Shanthi *. Studies on the regulation of synthesis of orotic acid from amino acids and its effect on liver tumor promotion. 1989.

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Book chapters on the topic "Orotic acid"

1

Takayama, K., and A. Furuya. "Microbial Production of Orotic Acid (Vitamin B13)." In Biotechnology of Vitamins, Pigments and Growth Factors. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-009-1111-6_16.

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2

Hernanz, Antonio, Ferenc Billes, Ioan Bratu, and Raquel Navarro. "Vibrational analysis and spectra of orotic acid." In Spectroscopy of Biological Molecules: New Directions. Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4479-7_101.

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3

Ohba, Satoru, Kiyoshi Kidouchi, Chie Nakamura, Toshiyuki Katoh, Masanori Kobayashi, and Yoshiro Wada. "Reference Values of Orotic Acid, Uracil and Pseudouridine in Urine." In Advances in Experimental Medicine and Biology. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-7703-4_6.

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4

Pardasani, R. T., and P. Pardasani. "Magnetic properties of polynuclear manganese(II) complex with L-dihydro-orotic acid." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54228-6_343.

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5

Laconi, Ezio, Pier P. Coni, Giuseppina Pichiri, Prema M. Rao, Srinivasan Rajalakshmi, and Dittakavi S. R. Sarma. "Possible Mechanism of Orotic Acid Induced Liver Tumor Promotion in the Rat." In Chemical Carcinogenesis. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4757-9640-7_27.

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6

Souchard, J. P., P. L. Fabre, J. P. Patau, M. Massol, P. Castan, and F. Nepveu. "Manganese(II) Complexes with Orotic Acid Derivatives as Scavengers of Superoxide Radicals." In Therapeutic Uses of Trace Elements. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-0167-5_43.

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7

Yusuf, A., K. L. Backway, E. Laconi, P. M. Rao, S. Rajalakshmi, and D. S. R. Sarma. "Development of resistance to the mitoinhibitory effects of orotic acid during experimental liver carcinogenesis." In Cell Growth and Oncogenesis. Birkhäuser Basel, 1998. http://dx.doi.org/10.1007/978-3-0348-8950-6_13.

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8

Chen, Jie, and Michael J. Bennett. "Quantitation of Orotic Acid in Urine Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-459-3_43.

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9

Vasudevan, Shanti, George Lee, Ijaz A. Qureshi, Prema M. Rao, Srinivasan Rajalakshmi, and Dittakavi S. R. Sarma. "Studies on Metabolic Perturbations and Tumor Promotion: Glycine Induces the Synthesis of Orotic Acid, a Tumor Promoter and the Expression of Certain Cell Cycle Dependent Genes." In Chemical Carcinogenesis. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4757-9640-7_37.

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10

"Orotic Acid." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_11958.

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Conference papers on the topic "Orotic acid"

1

Sarikaya, Ebru Karakaş, and Ömer Dereli. "Theoretical calculations of Electron Paramagnetic Resonance parameters of liquid phase Orotic acid radical." In TURKISH PHYSICAL SOCIETY 32ND INTERNATIONAL PHYSICS CONGRESS (TPS32). Author(s), 2017. http://dx.doi.org/10.1063/1.4976353.

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2

Gao, Peng, Duncan Woodward, Max Johnson, Leia Kaminsky, and Nicholas Gajkowski. "OPTIMIZING PLA PERFORMANCE: EFFECTS OF INJECTION MOLDING PARAMETERS AND OROTIC ACID ON MECHANICAL, THERMAL PROPERTIES AND ITS COMPOSTABILITY." In SAMPE 2025 Indianapolis. Society for the Advancement of Material and Process Engineering, 2025. https://doi.org/10.33599/nasampe/s.25.0228.

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Polylactic acid (PLA) is a biodegradable, bio-based polymer derived from renewable resources, making it an attractive alternative to petroleum-based plastics in various industries. However, its limited mechanical properties and thermal performance hinder its application in high-performance sectors such as aerospace. This study investigates the impact of crystallization behavior on PLA's mechanical, thermal, and composting properties, focusing on enhancing PLA's crystallization through the addition of orotic acid (OA) as a nucleating agent. PLA samples were processed with varying injection mold

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3

Kaninde, Abhidhamma, Tracey Conlon, Aida Abedin, Ingrid Borovickova, Patricia Fitzsions, and Ina Knerr. "P123 Maternal pernicious anaemia associated with anorexia and ketotic hypoglycaemia in a child with methylmalonic acid and orotic acid excretion in the urine – a case report." In Faculty of Paediatrics of the Royal College of Physicians of Ireland, 9th Europaediatrics Congress, 13–15 June, Dublin, Ireland 2019. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2019. http://dx.doi.org/10.1136/archdischild-2019-epa.478.

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Gao, Peng, Animesh Kundu, Khalid Alqosaibi, and John Coulter. "Enhanced Crystallinity Development of Poly-Lactic Acid by Dynamic Melt Manipulation." In ASME 2021 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/imece2021-73392.

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Abstract The primary objective of this research was to gain fundamental insight on the effect of imposed shear rates by dynamic melt modulation during injection molding on the crystallinity development of PLA. The dynamic melt modulation was achieved by a Dynamic & Intelligent Shear-Controlled Injection Molding (DISC-IM) instrument that utilized an in-house developed control system capable of oscillating the injection screw. The melt modulation process proved to be an efficient processing technique for enhanced properties in a particular commercial grade of PLA that contained various addit

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