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Journal articles on the topic 'Orotic acid'

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1

Haines, D. S. Milton, Margaret Wu, and Sonya D. Tokmakjian. "Dietary orotic acid accentuates the hepatic response to phenobarbital in rats." Biochemistry and Cell Biology 68, no. 9 (1990): 1146–49. http://dx.doi.org/10.1139/o90-171.

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In rats treated with phenobarbital for 3 days and simultaneously fed a semisynthetic diet containing 1.0% orotic acid, the extent of the increases in liver microsomal phosphatidylcholine, phosphatidylethanolamine, total RNA, total protein, and cytochrome P-450 were significantly greater than they were in rats treated identically with phenobarbital but without dietary orotic acid. This is attributed primarily to the stimulation of hepatic phosphatidylcholine synthesis by dietary orotic acid. In the absence of phenobarbital, orotic acid was shown to cause some increase in liver smooth endoplasmi
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2

Gerhardt, Valeska, Maya Tutughamiarso, and Michael Bolte. "Conformational studies of hydantoin-5-acetic acid and orotic acid." Acta Crystallographica Section C Crystal Structure Communications 68, no. 2 (2012): o92—o98. http://dx.doi.org/10.1107/s0108270112001151.

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Hydantoin-5-acetic acid [2-(2,5-dioxoimidazolidin-4-yl)acetic acid] and orotic acid (2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid) each contain one rigid acceptor–donor–acceptor hydrogen-bonding site and a flexible side chain, which can adopt different conformations. Since both compounds may be used as coformers for supramolecular complexes, they have been crystallized in order to examine their conformational preferences, giving solvent-free hydantoin-5-acetic acid, C5H6N2O4, (I), and three crystals containing orotic acid, namely, orotic acid dimethyl sulfoxide monosolvate, C5H4N2O
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3

Indy, Harvey E., and David C. Woollar. "Determination of Orotic Acid, Uric Acid, and Creatinine in Milk by Liquid Chromatography." Journal of AOAC INTERNATIONAL 87, no. 1 (2004): 116–22. http://dx.doi.org/10.1093/jaoac/87.1.116.

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Abstract A simultaneous determination of orotic acid, uric acid, and creatinine in milk is described. Following deproteinization, the sample was analyzed by reversed-phase liquid chromatography, using a highly aqueous cationic ion-pair eluent and photodiode array UV detection. In view of their potential dietary significance, the validated method was applied to survey the influence of species, season, and lactation on their contribution to the nonprotein nitrogen pool in milk. Mature bovine milk contained orotic acid, uric acid, and creatinine in the range of 30–70, 9–24, and 6–12 μg/mL, respec
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4

Shimamoto, Saki, Kiriko Nakamura, Shozo Tomonaga, Satoru Furukawa, Akira Ohtsuka, and Daichi Ijiri. "Effects of Cyclic High Ambient Temperature and Dietary Supplementation of Orotic Acid, a Pyrimidine Precursor, on Plasma and Muscle Metabolites in Broiler Chickens." Metabolites 10, no. 5 (2020): 189. http://dx.doi.org/10.3390/metabo10050189.

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The aim of this study was to evaluate the effects of high ambient temperature (HT) and orotic acid supplementation on the plasma and muscle metabolomic profiles in broiler chickens. Thirty-two 14-day-old broiler chickens were divided into four treatment groups that were fed diets with or without 0.7% orotic acid under thermoneutral (25 ± 1 °C) or cyclic HT (35 ± 1 °C for 8 h/day) conditions for 2 weeks. The chickens exposed to HT had higher plasma malondialdehyde concentrations, suggesting an increase in lipid peroxidation, which is alleviated by orotic acid supplementation. The HT environment
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5

Salač, Jan, Jana Šerá, Martin Jurča, Vincent Verney, Adam A. Marek, and Marek Koutný. "Photodegradation and Biodegradation of Poly(Lactic) Acid Containing Orotic Acid as a Nucleation Agent." Materials 12, no. 3 (2019): 481. http://dx.doi.org/10.3390/ma12030481.

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Orotic acid is a natural heterocyclic compound that acts as a nucleation agent in poly(lactic acid) (PLA). PLA materials with increasing orotic acid content were prepared and characterized. It was found that crystallinity of about 28% was reached with 0.3% content of the agent. Further enhancement in the content of the agent did not provoke any additional significant increase of crystallinity. Subsequently, it was investigated whether the orotic acid content affected photodegradation of PLA and, in the next phase, its biodegradation. The results of rheological measurements showed that the comp
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6

Gao, Peng, Davide Masato, Animesh Kundu, and John P. Coulter. "An Investigation on the Efficacy of Orotic Acid as a Bio-Nucleating Agent for Poly-Lactic Acid under Quiescent Condition and Injection Molding." Micromachines 13, no. 12 (2022): 2186. http://dx.doi.org/10.3390/mi13122186.

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Polylactic acid (PLA) is a bio-based biodegradable polymer and is considered to be an environmentally friendly alternative to petroleum-based polymers for various applications. Neat PLA requires an extended period at elevated temperatures to attain its maximum crystallinity, which can be mitigated by the addition of nucleating agents. Orotic acid is a natural heterocyclic nucleating agent in PLA. The effect of orotic acid on the crystallization behavior of a commercial, high-purity PLA was studied in detail. A differential scanning calorimetry (DSC) technique was utilized for this purpose. A n
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7

Motyl, T., A. Orzechowski, and Wanda Kukulska. "Urinary Orotic Acid Excretion in Hyperammonaemic Sheep; II. Renal Clearance of Orotic Acid." Journal of Veterinary Medicine Series A 35, no. 1-10 (1988): 232–35. http://dx.doi.org/10.1111/j.1439-0442.1988.tb00028.x.

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8

Beltyukova, S. V., O. I. Teslyuk, and E. O. Liventsova. "SORPTION-LUMINESCENT DETERMINATION OF OROTIC ACID IN MEDICINAL DRUGS." Odesa National University Herald. Chemistry 26, no. 1(77) (2021): 65–73. http://dx.doi.org/10.18524/2304-0947.2021.1(77).226138.

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Luminescent properties of orotic acid (vitamin B13), known bioactive substance, have been evaluated in this research. It has been shown that inside a coordination complex of orotic acid with terbium (III) an intermollecular excitation energy transfer from a ligand to a lanthanide ion occurs which causes sensitization of terbium (III) ion luminescence. Intensity of the terbium (III) ion luminescence (ILum) increases in the presence of anionic and cationic surfaceactive agents as a result of displacement of water molecules from coordination sphere of the complex. As a consequence of this process
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9

McCann, M. T., M. M. Thompson, I. C. Gueron, and M. Tuchman. "Quantification of orotic acid in dried filter-paper urine samples by stable isotope dilution." Clinical Chemistry 41, no. 5 (1995): 739–43. http://dx.doi.org/10.1093/clinchem/41.5.739.

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Abstract A rapid, sensitive, and specific method for quantification of orotic acid from dried filter-paper urine samples is described. The method involves stable isotope dilution with 1,3-[15N2]orotic acid analysis by gas chromatography-mass spectrometry. The assay is sufficiently sensitive to be used with solvent extraction techniques commonly used for urinary organic acid analysis. Extraction efficiencies of both native and isotopic orotic acid from dried filter paper and from water were 31% and 28%, respectively. The concentration of orotic acid in dried filter-paper urine specimens from 50
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10

Visek, W. J., and J. D. Shoemaker. "Orotic acid, arginine, and hepatotoxicity." Journal of the American College of Nutrition 5, no. 2 (1986): 153–66. http://dx.doi.org/10.1080/07315724.1986.10720122.

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11

Portalone, Gustavo. "Redetermination of orotic acid monohydrate." Acta Crystallographica Section E Structure Reports Online 64, no. 4 (2008): o656. http://dx.doi.org/10.1107/s160053680800562x.

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12

Haines, D. S. Milton, and Sonya D. Tokmakjian. "Actions of dietary orotic acid on liver synthesis of phosphatidylcholine and phosphatidylethanolamine in rats." Biochemistry and Cell Biology 65, no. 2 (1987): 105–11. http://dx.doi.org/10.1139/o87-015.

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The in vivo rates of the reactions of the cytidine pathways of liver phosphatidylcholine and phosphatidylethanolamine synthesis were measured in rats after 1 day of feeding on a semisynthetic diet containing 1% orotic acid. The calculations were made from the specific and total radioactivity versus time curves of the precursors and products following intraportal injection of [1,2-14C]choline, [2-14C]ethanolamine, and [2-3H]glycerol. The liver CTP level was increased twofold and the rates of CDP-choline and phosphatidylcholine synthesis were stimulated 4.5-fold in the rats fed orotic acid. The
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13

Jalundhwala, Forum J., Vaishali Y. Londhe, and Bharat S. Shah. "NEW APPROACH FOR ASSURING HIGHER QUALITY OF CALCIUM OROTATE BY ESTIMATING OROTIC ACID CONTENT USING STABILITY INDICATING RP-HPLC METHOD." INDIAN DRUGS 61, no. 08 (2024): 54–60. http://dx.doi.org/10.53879/id.61.08.14600.

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Calcium orotate is one of the highly prescribed calcium salts. The orotic acid content is crucial for exhibiting its high bioavailability. There are no methods available to estimate orotic acid content in calcium orotate. The primary objective of this study was to develop and validate a robust method for the estimation of orotic acid from the bulk calcium orotate. A stability indicating RP-HPLC method was developed using an isocratic condition of mobile phase comprising 20 mM of monobasic potassium phosphate in water (pH 2.5) with phosphoric acid at a flow rate of 1 mL min-1 over C-18 (ODS, 25
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14

Behrman, E. J. "5-Hydroxyorotic acid and orotic acid 5-sulfate." Journal of Chemical Research 2003, no. 11 (2003): 702–3. http://dx.doi.org/10.3184/030823403322862996.

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15

Chiara, Francesco, Sarah Allegra, Jacopo Mula, et al. "The Strange Case of Orotic Acid: The Different Expression of Pyrimidines Biosynthesis in Healthy Males and Females." Journal of Personalized Medicine 13, no. 10 (2023): 1443. http://dx.doi.org/10.3390/jpm13101443.

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Orotic acid (OA) is an intermediate metabolite of pyrimidine nucleotide biosynthesis and represents a minor diet constituent. The measurement of urinary orotic acid is useful in confirming the diagnosis of hereditary metabolic diseases. Moreover, it could be of interest to know how the physiological concentration of this metabolite changes in relation to different conditions of clinical normality. The purpose of this study was to determine the orotic acid concentration in the urine of healthy patients, to observe normal oroticuria and to evaluate if the expression of pyrimidine intermediate bi
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16

Brosnan, Margaret E., and John T. Brosnan. "Orotic Acid Excretion and Arginine Metabolism." Journal of Nutrition 137, no. 6 (2007): 1656S—1661S. http://dx.doi.org/10.1093/jn/137.6.1656s.

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17

Seiler, Nikolaus, Christine Grauffel, Guy Therrien, Shakir Sarhan, and Bernd Knoedgen. "Determination of orotic acid in urine." Journal of Chromatography B: Biomedical Sciences and Applications 653, no. 1 (1994): 87–91. http://dx.doi.org/10.1016/0378-4347(93)e0409-j.

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18

Нагиев, Э., E. Nagiev, С. Нагиева, S. Nagieva, Ф. Исмаилова, and F. Ismailova. "Study of Uridylic Nucleotides Contents and the Investigation Aspartate Carbamoyltransferase in Liver and Small Intestine Mucosa Exposed when Administered to Rats Orotic Acid and Perftoran." Medical Radiology and radiation safety 62, no. 5 (2017): 5–10. http://dx.doi.org/10.12737/article_59f2ef130f5421.00591025.

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Purpose: Study of uridylic nucleotides content and aspartate carbamoyltransferase which was a key enzyme on the pathway for the synthesis of pyrimidine nucleotides in tissues of irradiated animals upon administration of orotic acid and perftorane was conducted.
 Material and methods: Studies were performed on random-bred albino rats subjected to a single γ-ray exposure at a total dose of 6 Gy. Orotic acid was injected as potassium salt in a dose of 60 mg / kg, perftoran salt in a dose of 1 ml / 100 g water.
 Results: A decrease in the content of UTP and UDP, as well as an increase in
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19

Ribes, A., E. Riudor, M. Murillo, A. Maya, and A. Ballabriga. "Pyroglutamic acid as a marker of increased orotic acid." Journal of Inherited Metabolic Disease 10, S2 (1987): 311–13. http://dx.doi.org/10.1007/bf01811436.

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20

Hudson, Robert HE, and Filip Wojciechowski. "The detrimental effect of orotic acid substitution in the peptide nucleic acid strand on the stability of PNA2:NA triple helices." Canadian Journal of Chemistry 83, no. 10 (2005): 1731–40. http://dx.doi.org/10.1139/v05-180.

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We have investigated the incorporation of C6 derivatives of uracil into polypyrimidine peptide nucleic acid oligomers. Starting with uracil-6-carboxylic acid (orotic acid), a peptide nucleic acid monomer compatible with Fmoc-based synthesis was prepared. This monomer then served as a convertible nucleobase whereupon treatment of the resin-bound methyl orotate containing hexamers with hydroxide or amines cleanly converted the ester to an orotic acid or orotamide-containing peptide nucleic acid. Peptide nucleic acid hexamers containing the C6-modified nucleobase hybridized to both poly(riboadeny
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21

Sari, Dewi Ratih Tirto, Nadia Humairoh, Intani Quarta Lailaty, Gabriella Chandrakirana Krisnamurti, and Siti Zamilatul Azkiyah. "Kajian Farmakoinformatika Senyawa Caulerchlorin dan Racemosin sebagai kandidat Antimalaria." Biotropic : The Journal of Tropical Biology 8, no. 2 (2024): 11–21. http://dx.doi.org/10.29080/biotropic.v8i2.2080.

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Caulerchlorin and racemosin were bioactive compounds containing in Caulerpa racemosa macroalgae. Previous study, those compounds promoted therapeutical target on metabolic syndrome. However, the therapeutical activity on Malaria not yet defined. Therefore, this study investigated potential activity of caulerchlorin and racemosin from Caulerpa racemosa as antimalarial activity through pharmacoinformatic study. Caulerchlorin and racemosin structures were retrieved from PubChem NCBI and the Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) structure was taken out from Protein database
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22

Muftakhov, M. V., P. V. Shchukin, and R. V. Khatymov. "Resonant electron capture by orotic acid molecules." Russian Journal of Physical Chemistry A 91, no. 9 (2017): 1730–36. http://dx.doi.org/10.1134/s0036024417090229.

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23

MORIKAWA, Shinsuke, Keiichi UCHIDA, Shigeaki YONEMORI, Yoshio ODA, Akihiro YAMAZAKI, and Hirokazu MORISAWA. "Synthesis of 5-fluorouracil from orotic acid." NIPPON KAGAKU KAISHI, no. 11 (1985): 2185–90. http://dx.doi.org/10.1246/nikkashi.1985.2185.

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24

Motyl, T., A. Orzechowski, and S. Pierzynowski. "Urinary Orotic Acid Excretion in Hyperammonaemic Sheep." Journal of Veterinary Medicine Series A 34, no. 1-10 (1987): 522–28. http://dx.doi.org/10.1111/j.1439-0442.1987.tb00313.x.

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25

MOTYL, T., M. WINCENCIAK, S. BLACHOWSKI, et al. "Metabolic Effect of Orotic Acid in Calves*." Journal of Veterinary Medicine Series A 40, no. 1-10 (1993): 676–89. http://dx.doi.org/10.1111/j.1439-0442.1993.tb00684.x.

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26

Rosenfeldt, F. L., S. M. Richards, J. L. Fisher, and R. A. J. Conyers. "Mechanism of cardioprotective action of orotic acid." Asia Pacific Journal of Thoracic & Cardiovascular Surgery 5, no. 1 (1996): 56. http://dx.doi.org/10.1016/s1324-2881(96)90044-1.

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27

Hernanz, Antonio, Ferenc Billes, Ioan Bratu, and Raquel Navarro. "Vibrational analysis and spectra of orotic acid." Biopolymers 57, no. 3 (2000): 187–98. http://dx.doi.org/10.1002/(sici)1097-0282(2000)57:3<187::aid-bip7>3.0.co;2-6.

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28

Hilal, Rifaat, Z. M. Zaky, and Shabaan A. K. Elroby. "Electronic structure of orotic acid III geometric feature and thermal properties of some transition metal orotic acid complexes." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 63, no. 3 (2006): 740–48. http://dx.doi.org/10.1016/j.saa.2005.06.031.

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29

Song, Ping, Lin Sang, Liuchun Zheng, Chao Wang, Kankan Liu, and Zhiyong Wei. "Insight into the role of bound water of a nucleating agent in polymer nucleation: a comparative study of anhydrous and monohydrated orotic acid on crystallization of poly(l-lactic acid)." RSC Advances 7, no. 44 (2017): 27150–61. http://dx.doi.org/10.1039/c7ra02617j.

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30

Kostova, Irena, Jan Mojžiš, and Vasile Chiş. "Theoretical and Experimental Vibrational Characterization of Biologically Active Nd(III) Complex." Molecules 26, no. 9 (2021): 2726. http://dx.doi.org/10.3390/molecules26092726.

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The neodymium(III) complex of orotic acid (HOA) was synthesized and its structure determined by means of analytical and spectral analyses. Detailed vibrational analysis of HOA, sodium salt of HOA, and Nd(III)–OA systems based on both the calculated and experimental spectra confirmed the suggested metal–ligand binding mode. Significant differences in the IR and Raman spectra of the complex were observed as compared to the spectra of the ligand. The calculated vibrational wavenumbers, including IR intensities and Raman scattering activities, for the ligand and its Nd(III) complex were in good ag
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31

M'Boungou, Raoul, Michelle Petit-Ramel, Germaine Thomas-David, Gérard Perichet, and Bernard Pouyet. "Interactions du Cu(II), du Hg(II) et du Pt(II) avec les formes monomères et dimères de la thymine, de la thymidine et de l'acide orotique." Canadian Journal of Chemistry 65, no. 7 (1987): 1479–84. http://dx.doi.org/10.1139/v87-252.

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The protonation constants of monomeric (TM) and dimeric (TD) forms of thymine and monomeric (OM) and dimeric (OD) forms of orotic acid and thymidine (TY) have been calculated at 25 and 37 °C and at ionic strength μ = 0.1 (NaNO3). Under the same conditions the stability constants of their Cu(II), Hg(II), and Pt(II) complexes have been determined by protometric methods. The results have been discussed and a comparison has been established in terms of binding sites: nitrogen N3 for monomeric and dimeric forms of thymine and thymidine; carboxylate anion at C6 and adjacent ring nitrogen N1 for mono
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32

Ahn, Hee-Young, Kyu-Rim Park, and Young-Su Cho. "Effect of Fermented Angelica gigas Nakai on Lipid Metabolism in Orotic Acid Model Rats." Journal of Life Science 24, no. 7 (2014): 743–49. http://dx.doi.org/10.5352/jls.2014.24.7.743.

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33

Shibata, Takayuki, Tomohiro Narita, Yutaka Suto, Hasina Yasmin, and Tsutomu Kabashima. "A Facile Fluorometric Assay of Orotate Phosphoribosyltransferase Activity Using a Selective Fluorogenic Reaction for Orotic Acid." Sensors 23, no. 5 (2023): 2507. http://dx.doi.org/10.3390/s23052507.

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Orotate phosphoribosyltransferase (OPRT) exists as a bifunctional enzyme, uridine 5′-monophosphate synthase, in mammalian cells and plays an important role in pyrimidine biosynthesis. Measuring OPRT activity has been considered important for understanding biological events and development of molecular-targeting drugs. In this study, we demonstrate a novel fluorescence method for measuring OPRT activity in living cells. The technique utilizes 4-trifluoromethylbenzamidoxime (4-TFMBAO) as a fluorogenic reagent, which produces selective fluorescence for orotic acid. To perform the OPRT reaction, o
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34

Irena, Kostova. "Vibrational Characterization and Antioxidant Activity of Newly Synthesized Gallium(III) Complex." Open Journal of Chemistry 1, no. 1 (2015): 017–24. https://doi.org/10.17352/ojc.000004.

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The gallium(III) complex of orotic acid (HOA) was synthesized and its structure was determined by means of analytical and spectral analyses. Detailed vibrational analysis of HOA, sodium salt of HOA (NaOA) and Ga(III)-OA systems based on both the calculated and experimental spectra confi rmed the suggested metal-ligand binding mode. Signifi cant differences in the IR and Raman spectra of the complex were observed as compared to the spectra of the ligand and confi rmed the suggested metal-ligand binding mode. The calculated vibrational wavenumbers including IR and Raman scattering activities for
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35

Anzai, Naohiko, Daisak-u. Miura, and Hitoshi Endou. "Orotic acid transport via organic anion transporters OATs." Gout and Nucleic Acid Metabolism 32, no. 2 (2008): 141–46. http://dx.doi.org/10.6032/gnam1999.32.2_141.

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36

Saidi, B., and J. J. Warthesen. "Analysis and Stability of Orotic Acid in Milk." Journal of Dairy Science 72, no. 11 (1989): 2900–2905. http://dx.doi.org/10.3168/jds.s0022-0302(89)79440-6.

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37

Prachayasi, S., O. Wongsawatk, A. Worachartc, S. Ruchirawat, and V. Prachayasi. "Vasorelaxation and Superoxide Scavenging Activities of Orotic Acid." International Journal of Pharmacology 6, no. 4 (2010): 413–18. http://dx.doi.org/10.3923/ijp.2010.413.418.

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38

Karatas, F., S. Aydin, E. Kaygusuzoglu, H. Yildiz, F. A. Erulas, and Y. Ozkan. "Ghrelin and orotic acid increased in subclinical mastitis." Archives of Physiology and Biochemistry 114, no. 3 (2008): 178–82. http://dx.doi.org/10.1080/13813450802180940.

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39

Bowler, Jeannette T., Caitlin R. Clausen, Daniel J. Blackburn, and Weiming Wu. "Convenient synthesis of N1-substituted orotic acid derivatives." Tetrahedron Letters 55, no. 47 (2014): 6465–66. http://dx.doi.org/10.1016/j.tetlet.2014.10.005.

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40

Senger, Nicholas A., Jeannette T. Bowler, Rene S. Mercado, Sidney Lin, and Weiming Wu. "Improved synthesis of N1-substituted orotic acid derivatives." Tetrahedron Letters 54, no. 32 (2013): 4245–46. http://dx.doi.org/10.1016/j.tetlet.2013.05.136.

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41

Löffler, M., E. A. Carrey, and E. Zameitat. "Orotate (orotic acid): An essential and versatile molecule." Nucleosides, Nucleotides & Nucleic Acids 35, no. 10-12 (2016): 566–77. http://dx.doi.org/10.1080/15257770.2016.1147580.

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42

Shoemaker, J. D., and W. J. Visek. "Orotic acid overproduction in experimental cirrhosis of rats." Experimental and Molecular Pathology 50, no. 3 (1989): 371–84. http://dx.doi.org/10.1016/0014-4800(89)90046-4.

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43

Ernsting, M. J. E., and W. Th Nauta. "Preparation of thio-orotic acid labelled with S35." Recueil des Travaux Chimiques des Pays-Bas 72, no. 6 (2010): 527–28. http://dx.doi.org/10.1002/recl.19530720613.

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44

Ahn, Hee-Young, Da-Jeong Choe, and Young-Su Cho. "Improvement Effect of Fermented Orostachys malacophyllus against Orotic Acid-induced Fatty Liver Model Rats." Journal of Life Science 25, no. 8 (2015): 917–24. http://dx.doi.org/10.5352/jls.2015.25.8.917.

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45

Zammarchi, Enrico, Maria Alice Donati, Luca Filippi, and Massimo Resti. "Cryptogenic Hepatitis Masking the Diagnosis of Ornithine Transcarbamylase Deficiency." Journal of Pediatric Gastroenterology and Nutrition 22, no. 4 (1996): 380–83. http://dx.doi.org/10.1002/j.1536-4801.1996.tb00114.x.

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SummaryWe describe three children with transaminase elevations and hepatic insufficiency who were given the diagnosis of cryptogenic hepatitis after the more common viral and metabolic diseases of the liver had been excluded. However, further laboratory investigations showed hyperammonemia, low blood urea levels, elevated plasma glutamine levels, and low citrulline levels. Urinary excretion of orotic acid was higher than normal, with absent urinary homocitrulline and normal fractional tubular reabsorption of lysine, ornithine, and arginine. These findings suggest the diagnosis of ornithine tra
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46

Bruce, Michael J., Anthony R. Butler, and Kate V. Russell. "Formation of N-carbamoylaspartic acid and its cyclisation to orotic acid." Journal of the Chemical Society, Perkin Transactions 2, no. 2 (1994): 319. http://dx.doi.org/10.1039/p29940000319.

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47

Kovanskov, V. V., D. Yu Ivkin, E. D. Semivelichenko, G. A. Plisko, E. A. Kopacheva, and K. O. Sidorov. "Approbation of a Model of Fat Liver Disease Induced by Orotic Acid." Drug development & registration 11, no. 4 (2022): 240–45. http://dx.doi.org/10.33380/2305-2066-2022-11-4-240-245.

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Introduction. For the treatment of non-alcoholic fatty liver disease (NAFLD), hepatoprotective drugs are actively used. The existing models of non-alcoholic fatty liver disease used to study the effectiveness of medicinal products are characterized by a long duration of recovery and high mortality of test systems, in connection with which, the actual task is to test the screening model of this pathology. A number of studies have shown the hepatotoxic activity of orotic acid (OK), species-specific for rats, leading to the development of NAFLD.Aim. Approbation of the NAFLD model induced by oroti
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Pomar, Catalina A., Petr Zouhar, María DeLucas, et al. "Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of Lactation." Food Frontiers 6, no. 3 (2025): 1454–68. https://doi.org/10.1002/fft2.70017.

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ABSTRACTBreast milk provides a wide range of nutritional and bioactive components crucial for infant growth and development during lactation, ultimately influencing future health outcomes. Here, we used untargeted metabolomics to identify differences in the breast milk metabolome related to maternal overweight/obesity and diet, assessing their influence on infant weight gain in the first month of lactation. Anthropometric data from 52 lactating mother–infant pairs were collected at birth and 1 month postpartum, along with breast milk samples. Information about food consumed the day before milk
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Ahn, Hee-Young, Kyu-Rim Park, and Young-Su Cho. "The Improvement Effect of Fermented Angelica gigas Nakai Powder Against Orotic Acid-induced Fatty Liver in Rats." Journal of Life Science 24, no. 4 (2014): 411–18. http://dx.doi.org/10.5352/jls.2014.24.4.411.

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Fork, Christian, Tim Bauer, Stefan Golz, et al. "OAT2 catalyses efflux of glutamate and uptake of orotic acid." Biochemical Journal 436, no. 2 (2011): 305–12. http://dx.doi.org/10.1042/bj20101904.

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OAT (organic anion transporter) 2 [human gene symbol SLC22A7 (SLC is solute carrier)] is a member of the SLC22 family of transport proteins. In the rat, the principal site of expression of OAT2 is the sinusoidal membrane domain of hepatocytes. The particular physiological function of OAT2 in liver has been unresolved so far. In the present paper, we have used the strategy of LC (liquid chromatography)–MS difference shading to search for specific and cross-species substrates of OAT2. Heterologous expression of human and rat OAT2 in HEK (human embryonic kidney)-293 cells stimulated accumulation
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