Academic literature on the topic 'Orthomyxovirus-RNA Virus Family'

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Journal articles on the topic "Orthomyxovirus-RNA Virus Family"

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Presti, Rachel M., Guoyan Zhao, Wandy L. Beatty, et al. "Quaranfil, Johnston Atoll, and Lake Chad Viruses Are Novel Members of the Family Orthomyxoviridae." Journal of Virology 83, no. 22 (2009): 11599–606. http://dx.doi.org/10.1128/jvi.00677-09.

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ABSTRACT Arboviral infections are an important cause of emerging infections due to the movements of humans, animals, and hematophagous arthropods. Quaranfil virus (QRFV) is an unclassified arbovirus originally isolated from children with mild febrile illness in Quaranfil, Egypt, in 1953. It has subsequently been isolated in multiple geographic areas from ticks and birds. We used high-throughput sequencing to classify QRFV as a novel orthomyxovirus. The genome of this virus is comprised of multiple RNA segments; five were completely sequenced. Proteins with limited amino acid similarity to cons
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Mohr, PG, MStJ Crane, J. Hoad, et al. "Pilchard orthomyxovirus (POMV). I. Characterisation of an emerging virus isolated from pilchards Sardinops sagax and Atlantic salmon Salmo salar." Diseases of Aquatic Organisms 139 (April 30, 2020): 35–50. http://dx.doi.org/10.3354/dao03470.

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An orthomyxo-like virus was first isolated in 1998 as an incidental discovery from pilchards Sardinops sagax collected from waters off the South Australian coast. In the following 2 decades, orthomyxo-like viruses have been isolated from healthy pilchards in South Australia and Tasmania. In 2006, an orthomyxo-like virus was also isolated from farmed Atlantic salmon Salmo salar in Tasmania during routine surveillance and, again, from 2012 onwards from diseased Atlantic salmon. Using transmission electron microscopy, these viruses were identified as belonging to the family Orthomyxoviridae. To f
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Krossøy, Bjørn, Ivar Hordvik, Frank Nilsen, Are Nylund, and Curt Endresen. "The Putative Polymerase Sequence of Infectious Salmon Anemia Virus Suggests a New Genus within theOrthomyxoviridae." Journal of Virology 73, no. 3 (1999): 2136–42. http://dx.doi.org/10.1128/jvi.73.3.2136-2142.1999.

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ABSTRACT The infectious salmon anemia virus (ISAV) is an orthomyxovirus-like virus infecting teleosts. The disease caused by this virus has had major economic consequences for the Atlantic salmon farming industry in Norway, Canada, and Scotland. In this work, we report the cloning and sequencing of an ISAV-specific cDNA comprising 2,245 bp with an open reading frame coding for a predicted protein with a calculated molecular weight of 80.5 kDa. The putative protein sequence shows the core polymerase motifs characteristic of all viral RNA-dependent RNA polymerases. Comparison of the conserved mo
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Cook, Jonathan D., Azmiri Sultana, and Jeffrey E. Lee. "Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment." Proceedings of the National Academy of Sciences 114, no. 14 (2017): E2929—E2936. http://dx.doi.org/10.1073/pnas.1617993114.

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Orthomyxoviruses are an important family of RNA viruses, which include the various influenza viruses. Despite global efforts to eradicate orthomyxoviral pathogens, these infections remain pervasive. One such orthomyxovirus, infectious salmon anemia virus (ISAV), spreads easily throughout farmed and wild salmonids, constituting a significant economic burden. ISAV entry requires the interplay of the virion-attached hemagglutinin-esterase and fusion glycoproteins. Preventing infections will rely on improved understanding of ISAV entry. Here, we present the crystal structures of ISAV hemagglutinin
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Vogel, Dominik, Sigurdur Rafn Thorkelsson, Emmanuelle R. J. Quemin, et al. "Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein." Nucleic Acids Research 48, no. 10 (2020): 5749–65. http://dx.doi.org/10.1093/nar/gkaa253.

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Abstract The Bunyavirales order contains several emerging viruses with high epidemic potential, including Severe fever with thrombocytopenia syndrome virus (SFTSV). The lack of medical countermeasures, such as vaccines and antivirals, is a limiting factor for the containment of any virus outbreak. To develop such antivirals a profound understanding of the viral replication process is essential. The L protein of bunyaviruses is a multi-functional and multi-domain protein performing both virus transcription and genome replication and, therefore, is an ideal drug target. We established expression
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Chengula, Augustino Alfred, Stephen Mutoloki, Øystein Evensen, and Hetron Mweemba Munang’andu. "Tilapia Lake Virus Does Not Hemagglutinate Avian and Piscine Erythrocytes and NH4Cl Does Not Inhibit Viral Replication In Vitro." Viruses 11, no. 12 (2019): 1152. http://dx.doi.org/10.3390/v11121152.

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Tilapia lake virus (TiLV) is a negative-sense single-stranded RNA (-ssRNA) icosahedral virus classified to be the only member in the family Amnoonviridae. Although TiLV segment-1 shares homology with the influenza C virus PB1 and has four conserved motifs similar to influenza A, B, and C polymerases, it is unknown whether there are other properties shared between TiLV and orthomyxovirus. In the present study, we wanted to determine whether TiLV agglutinated avian and piscine erythrocytes, and whether its replication was inhibited by lysosomotropic agents, such as ammonium chloride (NH4Cl), as
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Bendl, Elias, Jonas Fuchs, and Georg Kochs. "Bourbon virus, a newly discovered zoonotic thogotovirus." Journal of General Virology 104, no. 8 (2023). http://dx.doi.org/10.1099/jgv.0.001887.

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The recent discovery of Bourbon virus (BRBV) put a new focus on the genus of thogotoviruses as zoonotic, tick-transmitted pathogens within the orthomyxovirus family. Since 2014, BRBV has been linked to several human cases in the Midwest United States with severe acute febrile illness and a history of tick bites. The detection of the virus in the Lone Star tick, Amblyomma americanum, and a high sero-prevalence in wild animals suggest widespread circulation of BRBV. Phylogenetic analysis of the viral RNA genome classified BRBV into the subgroup of Dhori-like thogotoviruses. Strikingly, BRBV is a
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Abu Rass, Reem, Japhette Esther Kembou-Ringert, Rachel Zamostiano, Avi Eldar, Marcelo Ehrlich, and Eran Bacharach. "Mapping of Tilapia Lake Virus entry pathways with inhibitors reveals dependence on dynamin activity and cholesterol but not endosomal acidification." Frontiers in Cell and Developmental Biology 10 (December 16, 2022). http://dx.doi.org/10.3389/fcell.2022.1075364.

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Tilapia Lake Virus (TiLV) is an emerging virus lethal to tilapia, which threatens the global tilapia aquaculture with severe implications for food security. TiLV possesses similar features to orthomyxoviruses but is classified in the sole and the monotypic genus Tilapinevirus of the family Amnoonviridae. TiLV enveloped virions encapsidate a genome comprising ten segments of single-stranded, negative RNA. Remarkably, nine of TiLV’s ten major proteins lack sequence homology to any known viral or cellular proteins. The mode of TiLV entry into tilapia cells is not known. Following the measurement
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Hao, Siyuan, Kang Ning, Çağla Aksu Küz, Shane McFarlin, Fang Cheng, and Jianming Qiu. "Eight Years of Research Advances in Bourbon Virus, a Tick-borne Thogotovirus of the Orthomyxovirus Family." Zoonoses 2, no. 1 (2022). http://dx.doi.org/10.15212/zoonoses-2022-0012.

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Bourbon virus (BRBV) was first isolated from a blood sample collected from a male patient living in Bourbon County, Kansas, during the spring of 2014. The patient later died because of complications associated with multiorgan failure. Several deaths due to BRBV infection have since been reported in the United States, and misdiagnosed cases are often undercounted. BRBV is a member of the genus Thogotovirus of the Orthomyxoviridae family, and is transmitted through the Lone Star tick, Amblyomma americanum, in North America. Currently, no specific antiviral agents or vaccines are available to tre
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Dissertations / Theses on the topic "Orthomyxovirus-RNA Virus Family"

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Najar, Tariq Ahmad. "Design and Stabilization of Stem Derived Immunogens from HA of Influenza A Viruses." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3863.

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Influenza virus belongs to the Orthomyxovirus family of viruses that causes respiratory infection in humans, leading to morbidity and mortality. The mature influenza A virion has an envelope that contains two major surface glycoproteins proteins – hemagglutinin (HA) and neuraminidase (NA). HA is a highly antigenic molecules and is responsible binding to host cell surface receptors (Sialic acid), and membrane fusion between the viral membrane and the host endosomal membrane. Most of the antibody response generated against influenza virus either by vaccination or by natural infection is directed
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Najar, Tariq Ahmad. "Design and Stabilization of Stem Derived Immunogens from HA of Influenza A Viruses." Thesis, 2015. http://etd.iisc.ernet.in/2005/3863.

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Influenza virus belongs to the Orthomyxovirus family of viruses that causes respiratory infection in humans, leading to morbidity and mortality. The mature influenza A virion has an envelope that contains two major surface glycoproteins proteins – hemagglutinin (HA) and neuraminidase (NA). HA is a highly antigenic molecules and is responsible binding to host cell surface receptors (Sialic acid), and membrane fusion between the viral membrane and the host endosomal membrane. Most of the antibody response generated against influenza virus either by vaccination or by natural infection is directed
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