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Journal articles on the topic 'Ory'

Author: Grafiati

Published: 4 June 2025

Last updated: 15 July 2025

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1

Albayrak İskender, Nurcan. "Endophytic bacterial diversity of Origanum rotundifolium: isolation and molecular identification of strains." Turkish Journal of Biodiversity 8, no. 1 (2025): 11–16. https://doi.org/10.38059/biodiversity.1704823.

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Endophytic bacteria in medicinal and aromatic plants provide valuable insights into the microbial diversity of these plants and form the basis for research on their ecological roles and biotechnological potential. In this study, the endophytic bacterial diversity of Origanum rotundifolium Boiss. was determined, and a total of eleven endophytic bacteria were isolated from the root, stem, and leaf tissues of O. rotundifolium. The isolated bacteria were characterized based on certain morphological and biochemical properties. Molecular identification was performed using 16S rRNA gene sequencing. The identified isolates were as follows: Kocuria rosea (OR1), Schumannella sp. (OR2), Micrococcus luteus (OR3, OR7), Bacillus proteolyticus (OR4), Curtobacterium flaccumfaciens (OR5), Staphylococcus sp. (OR6, OR10), Microbacterium proteolyticum (OR8), Microbacterium sp. (OR9), and Actinomyces sp. (OR11). This study reports, for the first time, the diversity of endophytic bacteria isolated from Origanum rotundifolium.

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2

Hai, Nguyen Luong. "Modeling of organizational behavior framwork for road usage charge management." Journal of Science and Technology in Civil Engineering (JSTCE) - HUCE 18, no. 1 (2024): 82–92. http://dx.doi.org/10.31814/stce.huce2024-18(1)-07.

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Organizational behavior plays a crucial role in effective management. However, there is limited research onorganizational behaviors in road usage charging management. This study aims to address this gap by identifying six dimensions of organizational behavior through focus group studies. Questionnaires were administered to 138 professionals in Vietnam, and the data were analyzed using structural equation modeling. The findings revealed six behavioral dimensions: Responsibilities fulfillment (OR1), Progress assurance (OR2), Aligned implementation organization (OR3), Hierarchical and delegated management (OR4), Efficient operation system (OR5), and Transparency and accountability assurance (OR6). Among these dimensions, OR2, OR4, and OR6 significantly impact management performance. Additionally, OR2 mediates the relationship between OR1 and management performance, OR4 mediates between OR3 and OR5, and OR5 indirectly influences management performance through OR6. It is expected that the efficacy of this approach will strengthen the significance of the organizing function and offer a valuable instrument to aid professionals in the field of road usage management.

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3

Hamilton, David. "Ory, Ory, Hallelujah!" Opera Quarterly 7, no. 3 (1990): 154–56. http://dx.doi.org/10.1093/oq/7.3.154.

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4

Tuan, Ngo Anh, Nguyen Luong Hai, and Pham Huy Tung. "Modeling of organizing function management in Vietnam’s public construction works." Journal of Project Management 7, no. 4 (2022): 191–200. http://dx.doi.org/10.5267/j.jpm.2022.5.003.

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Organizing function is the significant component of management guaranteeing the success of construction works. Many studies have been emphasizing on the topic of critical success factors (CSFs) within construction works, yet the results have rarely emphasized examining organizing behaviors within public construction work management; these less researched topics were the aims of this study. To fulfil this research aim, a regression analysis design was employed. Data were collected using questionnaires conducted from 139 professionals involved in public construction works management in Vietnam. The structural equation modelling (SEM) technique with partial least-squares estimation (PLS) was utilized to analyze the data. The results revealed 6 behavioral dimensions (i.e., structure organizing (OR1), authorization organizing (OR2), coordination organizing (OR4), human resource organizing (OR3), job organizing (OR5), responsibility organizing (OR6) to assess organizing function in terms of public construction work management. The study also reveals that structure organizing (OR1), authorization organizing (OR2), coordination organizing (OR4) have significant effects on management effectiveness (ME). In addition, coordination organizing (OR4) acts as the mediator of Human resource organizing (OR3), job organizing (OR5); while responsibility organizing (OR6) indicates an indirect influence through the mediator of OR5. The success of this approach is expected to reinforce the contribution of organizing function and suggest a useful tool for supporting the professionals in enhancing public construction work management.

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5

Du, Yichao, Furui Zhong, Huanli Cheng та ін. "The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome". Oxidative Medicine and Cellular Longevity 2021 (2 вересня 2021): 1–12. http://dx.doi.org/10.1155/2021/4628050.

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The purpose of this study is to investigate the protective effect of γ-oryzanol (ORY) against hepatic ischemia reperfusion (HIR) injury and the potential protective mechanisms of ORY. ORY is an important biologically active ingredient isolated from rice bran oil, which has anti-inflammatory and antiapoptotic effects. However, it is still unknown whether ORY can protect the liver from the HIR damage. In this study, ORY was administered orally for seven days, after which the animals were subjected to liver ischemia for 60 minutes and reperfused for 6 hours. Related indicators were analyzed. The results showed that ORY pretreatment significantly reduced the levels of AST and ALT, relieved hepatocellular damage and apoptosis, and attenuated the exhaustion of SOD and GSH and accumulation of MDA and MPO. Interestingly, ORY treatment could significantly decreased ER stress. Furthermore, ORY pretreatment remarkably reduced the protein expressions of HMGB1, NLRP3, caspase-1 (p20), and IL-1β to protect the liver from I/R-induced inflammasome activation and apoptosis. In conclusion, we demonstrated the potential effect of ORY in modulating oxidative stress, endoplasmic reticulum stress, and inflammasome activation during HIR.

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6

Ory, Pascal. "Pascal Ory." Le Débat 139, no. 2 (2006): 59. http://dx.doi.org/10.3917/deba.139.0059.

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7

Rungratanawanich, W., G. Abate, M. M. Serafini та ін. "Characterization of the Antioxidant Effects of γ-Oryzanol: Involvement of the Nrf2 Pathway". Oxidative Medicine and Cellular Longevity 2018 (14 березня 2018): 1–11. http://dx.doi.org/10.1155/2018/2987249.

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γ-Oryzanol (ORY) is well known for its antioxidant potential. However, the mechanism by which ORY exerts its antioxidant effect is still unclear. In this paper, the antioxidant properties of ORY were investigated for its potential effects as a reactive oxygen and nitrogen species (ROS/RNS) scavenger and in activating antioxidant-promoting intracellular pathways utilizing the human embryonic kidney cells (HEK-293). The 24 h ORY exposure significantly prevented hydrogen peroxide- (H2O2-) induced ROS/RNS production at 3 h, and this effect was sustained for at least 24 h. ORY pretreatment also enhanced the activity of antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GPX). Interestingly, ORY induced the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear translocation and upregulation of Nrf2-dependent defensive genes such as NAD(P)H quinone reductase (NQO1), heme oxygenase-1 (HO-1), and glutathione synthetase (GSS) at mRNA and protein levels in both basal condition and after H2O2 insult. Thus, this study suggested an intriguing effect of ORY in modulating the Nrf2 pathway, which is also involved in regulating longevity as well as age-related diseases.

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8

Xu, Wenxuan, Yuntao Wang, Jianmin Zhang, et al. "Dietary Oryzanol (Ory) Improved the Survival and Growth of Large Yellow Croaker (Larimichthys crocea) Larvae via Promoting Activities of Digestive Enzymes, Antioxidant Capacity, and Lipid Metabolism." Aquaculture Nutrition 2024 (May 14, 2024): 1–10. http://dx.doi.org/10.1155/2024/8368883.

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A feeding study lasting 30 days was carried out to determine the effects of dietary Oryzanol (Ory) on the survival, growth, antioxidant capacity, peptic enzymes, as well as lipid metabolism of Larimichthys crocea larvae (11.87 ± 0.59 mg) using four different Ory concentrations in microfeed formulations (0, 20, 40, and 80 mg/kg), all preserving isolipidic (18.25% crude lipid) and isonitrogenous (52.08% crude protein) conditions. Results revealed that larvae given 40 and 80 mg/kg Ory revealed markedly higher survival rates; in particular, the 80 mg/kg Ory larvae exhibited a considerably higher specific growth rate than the control. Furthermore, the 80 mg/kg dietary Ory resulted in increased peptic enzyme activity, indicating heightened digestive capabilities of larvae. Meanwhile, Ory supplementation at 20, 40, and 80 mg/kg also increased antioxidant enzyme activities and reduced malondialdehyde levels, indicating an enhanced antioxidant capacity. Moreover, the incorporation of 20 and 40 mg/kg Ory demonstrated efficacy in enhancing the lipid metabolism of the larvae. This was evident in the reduction of triglyceride and total cholesterol levels in the larval visceral mass, attributed to the downregulation of genes that participate in lipid synthesis, and the upregulation of genes associated with lipid catabolism. Overall, the study suggests that the addition of Ory (ranging from 40 to 80 mg/kg) significantly improves both survival and developmental aspects, possibly mediated by enhanced digestion and antioxidative effects, alongside the induction of lipid metabolism in Larimichthys crocea larvae.

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9

Abate, Giulia, Alex Pezzotta, Mariachiara Pucci, et al. "The Bioactive Gamma-Oryzanol from Oryza sativa L. Promotes Neuronal Differentiation in Different In Vitro and In Vivo Models." Antioxidants 13, no. 8 (2024): 969. http://dx.doi.org/10.3390/antiox13080969.

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Gamma-oryzanol (ORY), found in rice (Oryza sativa L.), is a mixture of ferulic acid esters with triterpene alcohols, well-known for its antioxidant and anti-inflammatory properties. Our past research demonstrated its positive impact on cognitive function in adult mice, influencing synaptic plasticity and neuroprotection. In this study, we explored whether ORY can exert neuro-differentiating effects by using different experimental models. For this purpose, chemical characterization identified four components that are most abundant in ORY. In human neuroblastoma cells, we showed ORY’s ability to stimulate neurite outgrowth, upregulating the expression of GAP43, BDNF, and TrkB genes. In addition, ORY was found to guide adult mouse hippocampal neural progenitor cells (NPCs) toward a neuronal commitment. Microinjection of ORY in zebrafish Tg (-3.1 neurog1:GFP) amplified neurog1-GFP signal, islet1, and bdnf mRNA levels. Zebrafish nrf2a and nrf2b morphants (MOs) were utilized to assess ORY effects in the presence or absence of Nrf2. Notably, ORY’s ability to activate bdnf was nullified in nrf2a-MO and nrf2b-MO. Furthermore, computational analysis suggested ORY’s single components have different affinities for the Keap1-Kelch domain. In conclusion, although more in-depth studies are needed, our findings position ORY as a potential source of bioactive molecules with neuro-differentiating potential involving the Nrf2 pathway.

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10

Burke, Penny Jane. "Intimidating/ory education." Research in Post-Compulsory Education 5, no. 3 (2000): 271–87. http://dx.doi.org/10.1080/13596740000200080.

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11

Cavalcanti, Fernando, Elena Gonzalez-Rey, Mario Delgado, et al. "Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis." Pharmaceutics 14, no. 7 (2022): 1420. http://dx.doi.org/10.3390/pharmaceutics14071420.

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Lysine specific demethylase 1 (LSD1; also known as KDM1A), is an epigenetic modulator that modifies the histone methylation status. KDM1A forms a part of protein complexes that regulate the expression of genes involved in the onset and progression of diseases such as cancer, central nervous system (CNS) disorders, viral infections, and others. Vafidemstat (ORY-2001) is a clinical stage inhibitor of KDM1A in development for the treatment of neurodegenerative and psychiatric diseases. However, the role of ORY-2001 targeting KDM1A in neuroinflammation remains to be explored. Here, we investigated the effect of ORY-2001 on immune-mediated and virus-induced encephalomyelitis, two experimental models of multiple sclerosis and neuronal damage. Oral administration of ORY-2001 ameliorated clinical signs, reduced lymphocyte egress and infiltration of immune cells into the spinal cord, and prevented demyelination. Interestingly, ORY-2001 was more effective and/or faster acting than a sphingosine 1-phosphate receptor antagonist in the effector phase of the disease and reduced the inflammatory gene expression signature characteristic ofEAE in the CNS of mice more potently. In addition, ORY-2001 induced gene expression changes concordant with a potential neuroprotective function in the brain and spinal cord and reduced neuronal glutamate excitotoxicity-derived damage in explants. These results pointed to ORY-2001 as a promising CNS epigenetic drug able to target neuroinflammatory and neurodegenerative diseases and provided preclinical support for the subsequent design of early-stage clinical trials.

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12

Imbert, Frédéric. "Bibliographie de Solange Ory." Bulletin d’études orientales, no. LXVII (December 1, 2020): 27–32. http://dx.doi.org/10.4000/beo.6791.

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13

Duclos, Jean-François. "Zanipolo by Marc Ory." French Review 85, no. 2 (2011): 405–6. http://dx.doi.org/10.1353/tfr.2011.0054.

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14

Harris, Dale. "Le comte Ory (1828)." Opera Quarterly 9, no. 4 (1993): 256–59. http://dx.doi.org/10.1093/oq/9.4.256.

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15

Tuanaya, Mirza Raisa, Mike Jurnida Rolobessy, and Syaiful Rijal Mahulauw. "Peran Perempuan Dalam Penyelesaian Konflik Dusun Ory Pada Negeri Pelauw dengan Negeri Kariu Kabupaten Maluku Tengah." Journal of Government Science Studies 3, no. 1 (2024): 35–44. http://dx.doi.org/10.30598/jgssvol3issue1page35-44.

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resolving the conflict berween Ory Hamlet, Pelauw State and Kariu State. This research was carried oud in Ory Hamlet, Pelauw State and Kariu State. Primary data collection techniques were carried out through interviews with a number of informant who were considered to be involved in the process of resolving the conflict between Ory Hamlet, Pelauw State and Kariu State.The results of this research show that so far in conflicts, women and children have only been considered victims, even though the informal effoots made by women have also made a positive contribution to the peacemaking process. However, in formal spaces, women’s involvement I very minimal, because they are not in strategic positions in the leadersip structure.

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16

Marasabessy, Roos Nilawati, Wilda Fesanrey, Amaliah F. Ambon, and Susiati Susiati. "KONDISI LAMUN DI PERAIRAN DUSUN ORY PULAU HARUKU KABUPATEN MALUKU TENGAH." Jurnal Perikanan dan Kelautan 27, no. 2 (2022): 227. http://dx.doi.org/10.31258/jpk.27.2.227-234.

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Research on the condition of seagrass communities in the waters of Ory village is important to do as a basis for management strategies and data on seagrass meadow conditions. The purpose of this study is to find out the current seagrass conditions (2021) and to find out the structure of the seagrass meadow community formed and the biota associated with seagrass in Ory waters. This research was conducted in June-August 2021 in the waters of Ory village of Haruku Island, Central Maluku District. The sampling technique in this study is based on the use of the square transect line method. Seagrass sampling is done at low tide using a square of 0.5 x 0.5 m with the size of each plot of 0.1 x 0.1 m as much as 25 plots. The data analysis method for occurence frequency calculation, type coverage, while to know seagrass conditions. Based on the results of the study, there are 5 types of seagrass in the waters of Ory village, namely Thalassia hemprichii, Enhalus acoroides, Cymodocea rotundata, Halophila ovalis, and Halodule pinifolia. The density value of seagrass in the waters of Ory village is 322 shoots / m2 (very tight), the frequency of Enhalus acoroides species is more widespread than other types, and the covering value of seagrass is 98.45% (good, healthy / rich). The highest INP is in the Enhalus acoroides, and the biota species associated with seagrass are A. granosa, Linckia laevigata, P. nododsus, and Holothuria scabra

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17

Mastinu, Andrea, Sara Bonini, Wiramon Rungratanawanich, et al. "Gamma-oryzanol Prevents LPS-induced Brain Inflammation and Cognitive Impairment in Adult Mice." Nutrients 11, no. 4 (2019): 728. http://dx.doi.org/10.3390/nu11040728.

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Background: Rice (Oryza sativa L.) is the main food source for more than half of humankind. Rice is rich in phytochemicals and antioxidants with several biological activities; among these compounds, the presence of γ-oryzanol is noteworthy. The present study aims to explore the effects of γ-oryzanol on cognitive performance in a mouse model of neuroinflammation and cognitive alterations. Methods: Mice received 100 mg/kg γ-oryzanol (ORY) or vehicle once daily for 21 consecutive days and were then exposed to an inflammatory stimulus elicited by lipopolysaccharide (LPS). A novel object recognition test and mRNA expression of antioxidant and neuroinflammatory markers in the hippocampus were evaluated. Results: ORY treatment was able to improve cognitive performance during the neuroinflammatory response. Furthermore, phase II antioxidant enzymes such as heme oxygenase-1 (HO-1) and NADPH-dehydrogenase-quinone-1 (NQO1) were upregulated in the hippocampi of ORY and ORY+LPS mice. Lastly, γ-oryzanol showed a strong anti-inflammatory action by downregulating inflammatory genes after LPS treatment. Conclusion: These results suggest that chronic consumption of γ-oryzanol can revert the LPS-induced cognitive and memory impairments by promoting hippocampal antioxidant and anti-inflammatory molecular responses.

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18

Kerim, Tursun, Nijat Imin, Jeremy J. Weinman, and Barry G. Rolfe. "Proteomic analysis reveals developmentally expressed rice homologues of grass group II pollen allergens." Functional Plant Biology 30, no. 8 (2003): 843. http://dx.doi.org/10.1071/fp03100.

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Three isoallergens of Ory s 2, homologues of grass group II pollen allergens, were identified from rice and characterised by proteome and immunochemical analyses. The N-terminal amino acid sequence profiles of three proteins on a 2-dimensional electrophoresis (2-DE) gel of rice pollen proteins matched 100% to the protein sequences encoded by three rice expressed sequence tags (ESTs). The deduced protein sequences from these ESTs share sequence identities of 41–43% with the protein sequences of the group II pollen allergens of different grasses, and sequence identity of 39% with the C-terminal portion of rice group I pollen allergens. Signal peptide sequences, which are similar to the leader peptides of other major pollen allergens, are also present in the deduced amino acid sequences. Polyclonal antibodies, produced in rabbits using Ory s 2 proteins purified by 2-DE, were used to investigate the developmental-stage- and tissue-specific expression of Ory s 2 by immunochemical analysis. Results of immunochemical experiments show that Ory s 2 proteins are expressed only at the late stage of pollen development and they do not have cross-reactivity with group II pollen allergens from some other common grasses.

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19

Latuconsina, Rasyid, Carolina Selfisina Ayal, and Hanisa Tamalene. "PENINGKATAN HASIL BELAJAR PESERTA DIDIK MENGGUNAKAN PENDEKATAN CONTEXCTUAL TEACHING AND LEARNING (CTL) PADA MATERI STATISTIKA." Jurnal Pendidikan Matematika Unpatti 3, no. 3 (2022): 100–109. http://dx.doi.org/10.30598/jpmunpatti.v3.i3.p100-109.

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Penelitian ini bertujuan untuk meningkatkan hasil belajar peserta didik kelas VIII MTs Nadil Ulum Ory dengan menggunakan pendekatan Contextual Teaching and Learning (CTL) pada materi Statistika. Pendekatan contextual teaching and learning dengan tujuh komponen utama (contructivisme, inquiry, questioning, learing community, modeling, dan authentic assesment) adalah pembelajaran yang mambantu peserta didik mengaitkan materi pelajaran dengan kehidupan nyata. Subjek dalam penelitian ini adalah peserta didik kelas VIII MTs Nadil Ulum Ory yang berjumlah 20 orang. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) yang berlangsung selama 2 siklus. Pengumpulan data dilakukan dengan lembaran observasi dan tes akhir pada setiap siklus. Teknik analisis data yang digunakan adalah teknik analisis data kuantitatif dan kualitatitif. Hasil penelitian ini diperoleh bahwa terjadi peningkatan hasil belajar peserta didik dari siklus I terdapat 9 orang yang mencapai nilai kriteria Ketuntasan Minimal (KKM) yaitu yang ditetapkan di MTs Nadil Ulum Ory atau dengan persentase Sedangkan pada siklus II terdapat 17 orang dengan persentase atau yang mencapai nilai KKM. Dapat disimpulkan bahwa pembelajaran dengan menggunakan Pendekatan Contextual Teaching and Learning (CTL) dapat meningkatkan hasil belajar peserta didik kelas VIII MTs Nadil Ulum Ory pada materi statistika

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20

Imbert, Frédéric. "Solange Ory (1927‑2018), épigraphiste." Bulletin d’études orientales, no. LXVII (December 1, 2020): 21–25. http://dx.doi.org/10.4000/beo.6787.

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21

Deitz, Ritt. "La concession by Marc Ory." French Review 86, no. 3 (2013): 609–10. http://dx.doi.org/10.1353/tfr.2013.0472.

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22

Shewan, Rodney. "Le Comte Ory. Gioachino Rossini." Opera Quarterly 6, no. 4 (1989): 116–20. http://dx.doi.org/10.1093/oq/6.4.116.

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23

Harris, Dale. "Le Comte Ory. Gioachino Rossini." Opera Quarterly 7, no. 3 (1990): 151–54. http://dx.doi.org/10.1093/oq/7.3.151.

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24

Arend, Thomas. "Gioachino Rossini: Le Comte Ory." Die Musikforschung 70, no. 3 (2024): 309–11. https://doi.org/10.52412/mf.2017.h3.3683.

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25

Sari-Aslani, Koroush, Nahid Davoodian, Shiva Zeini, Seyed Abdollah Mousavi та Ebrahim Eftekhar. "γ-oryzanol ameliorates the oxidative stress and inflammatory response in a mice model of LPS-induced liver injury". Disease and Diagnosis 13, № 3 (2024): 107–13. http://dx.doi.org/10.34172/ddj.1585.

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Background: γ-Oryzanol (ORY) is a main component of rice bran oil and consists of a mixture of phytosteryl ferulates with antioxidant and anti-inflammatory properties. The purpose of this study was to evaluate the protective effects of ORY on hepatic oxidative damage and inflammatory response induced by lipopolysaccharide (LPS) in adult male mice. Materials and Methods: Adult male BALB/c mice (n=24) were intraperitoneally administered either LPS (0.75 mg/kg/d) or saline for a week. Meanwhile, mice were supplemented with ORY (100 mg/kg/d, gavage) or vehicle for 2 weeks. After treatment, animals were sacrificed and the markers of liver injury including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were evaluated in blood. In addition, we measured the oxidative stress and inflammatory markers including lipid peroxidation (TBARS), total free thiol, catalase activity, tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and nuclear factor kappa B (NF-κB) expression levels in hepatic tissue. Results: Systemic LPS injections induced oxidative stress in the liver of treated animals, characterized by increased TBARS, with significantly decreased catalase activity and total free thiol content. Besides, the serum levels of ALT and AST increased in all experimental groups compared with the control group. These findings were accompanied by the increased hepatic expression levels of IL-6, IL-1β, TNF-α, and NF-κB. Furthermore, pathological evaluation of tissues showed LPS-induced microvesicular steatosis, which was ameliorated by ORY supplementation for two weeks. Conclusion: In summary, our results demonstrate that LPS-induced hepatic damage is mitigated by ORY supplementation in adult mice. These findings support the idea that natural products can protect against hepatotoxicity.

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26

James, S. W., L. P. Ranum, C. D. Silflow, and P. A. Lefebvre. "Mutants resistant to anti-microtubule herbicides map to a locus on the uni linkage group in Chlamydomonas reinhardtii." Genetics 118, no. 1 (1988): 141–47. http://dx.doi.org/10.1093/genetics/118.1.141.

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Abstract We have used genetic analysis to study the mode of action of two anti-microtubule herbicides, amiprophos-methyl (APM) and oryzalin (ORY). Over 200 resistant mutants were selected by growth on APM- or ORY-containing plates. The 21 independently isolated mutants examined in this study are 3- to 8-fold resistant to APM and are strongly cross-resistant to ORY and butamiphos, a close analog of APM. Two Mendelian genes, apm1 and apm2, are defined by linkage and complementation analysis. There are 20 alleles of apm1 and one temperature-sensitive lethal (33 degrees) allele of apm2. Mapping by two-factor crosses places apm1 6.5 cM centromere proximal to uni1 and within 4 cM of pf7 on the uni linkage group, a genetically circular linkage group comprising genes which affect flagellar assembly or function; apm2 maps near the centromere of linkage group VIII. Allele-specific synthetic lethality is observed in crosses between apm2 and alleles of apm1. Also, self crosses of apm2 are zygotic lethal, whereas crosses of nine apm1 alleles inter se result in normal germination and tetrad viability. The mutants are recessive to their wild-type alleles but doubly heterozygous diploids (apm1 +/+ apm2) made with apm2 and any of 15 apm1 alleles display partial intergenic noncomplementation, expressed as intermediate resistance. Diploids homozygous for mutant alleles of apm1 are 4-6-fold resistant to APM and ORY; diploids homozygous for apm2 are ts- and 2-fold resistant to the herbicides. Doubly heterozygous diploids complement the ts- phenotype of apM2, but they are typically 1.5-2-fold resistant to APM and ORY. From the results described we suggest that the gene products of apm1 and apm2 may interact directly or function in the same structure or process.

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27

Colas, Damien. "Questioning the frenchness of Le comte Ory." Studia Musicologica 52, no. 1-4 (2011): 373–92. http://dx.doi.org/10.1556/smus.52.2011.1-4.27.

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To talk about the Frenchness of Le comte Ory might sounds like provocation. Being basically a rifacimento of his Viaggio a Reims, Rossini’s penultimate stage work belongs to the corpus of Italo-French operas. Yet there are three reasons for looking at Le comte Ory as an authentic French opera. Firstly, in the newly composed parts of the work, Rossini avoided the traditional features of the closed numbers typical of the Italian tradition by inserting recitatives inside the numbers and by merging closed numbers and subsequent recitatives, especially at the end of Act II. Secondly, the French lines written by Scribe to fit the already composed music follow poetic patterns from the Middle Ages, of which the prosodic features were closer to Italian than Classical French. Last, the very choice of the legend of Ory is typical of the troubadour style that had been fashionable in Paris since the last decades of the 18th century, and it turns out that this particular legend was extremely popular back then, as witnessed by the variety of local variants that were published in the 19th century.

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28

ZAMMA, HIDEKI. "ACCENTUATION OF -ORY, -IVE, AND -ION." ENGLISH LINGUISTICS 12 (1995): 248–71. http://dx.doi.org/10.9793/elsj1984.12.248.

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29

Domingo Martín, Javier. ""Monstruos infernales en mis sílabas". Ecos fantásticos y maravillosos en la poesía de Carlos Edmundo de Ory." Tropelías: Revista de Teoría de la Literatura y Literatura Comparada, no. 32 (July 6, 2019): 72–82. http://dx.doi.org/10.26754/ojs_tropelias/tropelias.2019323450.

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El elemento fantástico en la obra poética de Carlos Edmundo de Ory es un marco genérico esencial para muchos de sus textos. En este artículo, analizaremos su poesía fantástica a partir del estudio de los elementos maravillosos y fantásticos que en ella aparecen y de los poemas que pertenecen propiamente al género. Concluiremos que lo fantástico en Ory es una herramienta epistemológica que le permite explorar áreas de lo real inaccesibles al conocimiento racional, así como un espacio de reflexión sobre la escritura poética y la identidad personal, que es, signo de la posmodernidad, inestable y problemática.

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Maes, Tamara, Iñigo Tirapu, Cristina Mascaró, et al. "Preclinical characterization of a potent and selective inhibitor of the histone demethylase KDM1A for MLL leukemia." Journal of Clinical Oncology 31, no. 15_suppl (2013): e13543-e13543. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e13543.

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e13543 Background: The lysine-specific demethylase KDM1A catalyzes the removal of methyl groups from mono and dimethylated H3K4/K9, changes that have inductive or inhibitory effects on gene expression. KDM1A is a key regulator of leukemia stem cell (LSC) potential and is required for MLL-AF9 oncogenic transformation. Inhibition of KDM1A expression or activity overcomes the differentiation block in AML. Mixed lineage leukemia (MLL) is a form of AML that is especially sensitive to inhibition of KDM1A. Methods: Gene expression was analyzed using microarrays, cell differentiation was assessed by FACS, viability and apoptosis were assessed by MTT assay and PI staining, me2H3K4 levels were quantified by qPCR and ChIPseq. Results: We used computational models based on reported X-ray structures fine-tuned with the SAR of a first series of molecules to design and synthesize >800 KDM1A inhibitors. ORY-1001 is an enantiomerically pure KDM1A inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). ORY-1001 does not inhibit non-related histone modifiers, and is clean in a CEREP diversity panel. Treatment of THP-1 (MLL-AF9) cells with ORY-1001, results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers (EC50 me2H3K4 and FACS CD11b <1nM). Microarray analysis of treated THP-1 cells reveals differentiation towards a monocyte-like phenotype. ORY-1001 induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells (EC50 <1nM). Daily oral administration of doses <0.020mg/kg leads to significantly reduced tumor growth in rodent MV(4;11) xenografts. In vivo and in vitro IND/IMPD enabling studies have shown that ORY-1001 presents excellent oral bioavailability, target exposure and activity in vivo. The compound is stable in hepatocytes (Clint<0.6 mL/min/g liver, @1uM) and does not exhibit CYP (IC50>100uM) or hERG (%inhib.<2%, @10uM) inhibition. No off-target activity has been detected in 28d rat toxicology studies. Conclusions: A potent and selective KDM1A inhibitor is described with in vitro and vivo anti-leukemic efficacy.

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James, S. W., C. D. Silflow, M. D. Thompson, L. P. Ranum, and P. A. Lefebvre. "Extragenic suppression and synthetic lethality among Chlamydomonas reinhardtii mutants resistant to anti-microtubule drugs." Genetics 122, no. 3 (1989): 567–77. http://dx.doi.org/10.1093/genetics/122.3.567.

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Abstract The antimicrotubule agents oryzalin (ORY), colchicine (COL) and taxol (TAX) were used to select three recessive, conditional lethal (ts-) mutants which defined two new essential loci, ory1 and cor1. The two ory1 mutants conferred resistance to ORY, TAX, and COL; the cor1 mutant conferred resistance only to COL. Each of the mutants displayed wild-type sensitivity to a number of unrelated inhibitors. Assembly and disassembly of flagellar microtubules in the ory1 mutants displayed wild-type sensitivity to ORY and COL, suggesting that the ory1 gene product either does not participate in these processes or the ory1 gene product alone is not sufficient to confer resistance. The ory1 locus mapped to linkage group X; cor1 was mapped to the left arm of linkage group XII. A synthetic lethal interaction was observed between ory1 and cor1 mutations, i.e., inferred ory1 cor1 double mutants were inviable at the permissive temperature. The conditional lethal phenotype of ory1-1 was used to select many spontaneous TS+ revertants, which arose at high frequencies. Genetic and phenotypic characterization of the revertants demonstrated that (1) the revertants fell into four phenotypic classes, including some which conferred supersensitivity to ORY and others which conferred cold-sensitive lethality, (2) reversion was caused in most or all cases by extragenic suppressors, (3) suppressor mutations displayed complex behavior in heterozygous (sup/+) diploids, (4) many different loci may be capable of suppressing ory1 mutants, and (5) suppressors of ory1-1 efficiently suppressed an independently isolated allele, ory1-2. Taken together the ory1, cor1, and suppressor mutations identify a number of interacting loci involved in essential cellular processes which are specifically susceptible to antimicrotubule agents.

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Stallknecht, Michael. "Die PFLANZEN TANZEN." Opernwelt 63, no. 11 (2022): 18–21. http://dx.doi.org/10.5771/0030-3690-2022-11-018.

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Tayari, Mina M., Tulasigeri M. Totiger, Ramin Shiekhattar, Justin Taylor, and Justin M. Watts. "The LSD1 Inhibitor Ory-1001 (ladademstat) in Combination with Menin Inhibitor SNDX-5613 (revumenib) Has Synergistic in Vitro Activity in KMT2A-Rearranged AML Models." Blood 142, Supplement 1 (2023): 5691. http://dx.doi.org/10.1182/blood-2023-190309.

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Introduction: Menin is a scaffold protein that binds to gene promoters, enhancers and transcription factors, thereby influencing transcription. Leukemias with rearrangement of KMT2A known as mixed-lineage leukemia (MLL), as well as other abnormalities such as NPM1c, respond to Menin inhibition with promising early clinical results. MLL leukemias affect children and adults and are associated with high rates of resistance to conventional chemotherapy. In addition to these alterations, other leukemia subsets with similar transcriptional dependency could be targeted through Menin inhibition. LSD1 is an essential regulator of murine MLL-AF9 leukemia stem cells (LSCs) and maintains the LSC potential of MLL-AML cells through blocking of differentiation and apoptosis ( Harris et al, 2012). LSD1 acts at genomic loci that are bound by MLL-AF9 to maintain expression of the associated leukemogenic program, thus preventing differentiation and apoptosis. We investigated the pre-clinical efficacy of combined Menin and LSD1 inhibition in AML. PC4 and SF2 interacting protein 1 (PSIP1)/p75, also known as LEDGF, interacts with the N-terminus of MLL and Menin. This complex contributes to the association of MLL and MLL-fusion multiprotein complexes with the chromatin. Several studies have shown that both PSIP1 and Menin are required for efficient MLL-fusion-mediated leukemogenesis and for the expression of MLL-regulated genes. A proposed model of LSD1 interaction with KMT2A-Menin-PSIP1 suprcomplex is depicted in Fig. 1A. Methods: To assess in vitro LSD1 inhibitor (ORY-1001) and Menin inhibitor (SNDX) potency, cell lines were plated and treated with the respective doses of ORY-1001, SNDX, and the combination of these drugs in 96-well plates. We performed synergy assays using increasing concentrations of SNDX and 3µM of ORY-1001. Cell viability and IC50 were measured after 4 days of treatment. The SynergyFinder 2.0 web application was used to calculate synergy scores and generate 2D synergy maps. Western blotting of LSD1, co-immunoprecipitation, and ChIP-qPCR studies were used to assess the depletion of the LSD1 from chromatin. The interaction network of LSD1 interactome proteins was assessed by mass spectrometry. Results: We showed that LSD1 degrades with increasing concentrations of ORY-1001 after 48h of treatment (Fig.1 B). IC 50 curves for ORY-1001, SNDX and synergy effect is shown with increasing concentrations of SNDX and 3µM ORY-1001 in MV4-11 cells (expressing MLL-AF4) (Fig.1 C). ORY-1001 alone shows an IC 50 of ~0.5 µM, and SNDX alone shows an IC 50 of ~10 nM. The combination of LSD1 and SNDX inhibitors synergistically reduced cell viability in MLL-rearranged MOLM-13 and MV4-11 cells (Fig.1 C). We also assayed the LSD1 endogenous protein interactome in MOLM-13 cells (expressing MLL-AF9) by mass spectrometry. Our LSD1 interactome analysis revealed an association of LSD1 with previously identified interactors such as RCOR1, HDAC1, HDAC2, CARM1 and HMG20B. We discovered an unexpected association between LSD1 and PSIP1. Interestingly, PSIP1 interact with MLL1-MEN1 complex and its crucial for assembling MLL-fusion proteins to their gene targets. Conclusion: LSD1 Inhibitor ladademstat in Combination with Menin Inhibitor revumenib has synergistic effect in KMT2A-Rearranged AML models. Surprisingly, we also found that PSIP1, which is essential for inducing MLL-rearranged leukemia, interacts with LSD1. This suggests that PSIP1 may modulate gene expression through its ability to interact with both MLL1 and LSD1. This study opens a new avenue to investigate the role of KMT2A-MEN1 in relation to other epigenetic modifiers, such as LSD1, and guide new potential combination therapies that may further potentiate differentiation and elimination of leukemia LSCs.

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Xu (徐昊), Hao. "Smuggle tau through a secret(ory) pathway." Biochemical Journal 478, no. 14 (2021): 2921–25. http://dx.doi.org/10.1042/bcj20210324.

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Secretion of misfolded tau, a microtubule-binding protein enriched in nerve cells, is linked to the progression of tau pathology. However, the molecular mechanisms underlying tau secretion are poorly understood. Recent work by Lee et al. [Biochemical J. (2021) 478: 1471–1484] demonstrated that the transmembrane domains of syntaxin6 and syntaxin8 could be exploited for tau release, setting a stage for testing a novel hypothesis that has profound implications in tauopathies (e.g. Alzheimer's disease, FTDP-17, and CBD/PSP) and other related neurodegenerative diseases. The present commentary highlights the importance and limitations of the study, and discusses opportunities and directions for future investigations.

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Seurrat, Aude. "Pascal Ory, Christian Delporte, Bertrand Tillier, Laurent." Questions de communication, no. 28 (December 31, 2015): 370–71. http://dx.doi.org/10.4000/questionsdecommunication.10271.

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Lytle, Ephraim. "From Alexander to Jesus by Ory Amitay." Mouseion: Journal of the Classical Association of Canada 1012, no. 1 (2012): 109–14. http://dx.doi.org/10.1353/mou.2012.0011.

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龚, 鑫. "Three Mistakes of “Philosophy Useless The-ory”." Advances in Philosophy 11, no. 06 (2022): 1908–11. http://dx.doi.org/10.12677/acpp.2022.116326.

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38

Weisselberg, Jean-Pierre. "Pascal Ory, De la haine du juif." Humanisme N° 337, no. 4 (2022): 119–20. http://dx.doi.org/10.3917/huma.337.0119.

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39

van Praag, Yannik. "Pascal Ory. “De la haine du Juif”." Témoigner. Entre histoire et mémoire, no. 135 (October 10, 2022): 130–31. http://dx.doi.org/10.4000/temoigner.11531.

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40

Callizo-Soneiro, Javier. "Bielza de Ory, V. (2022) Lo urbano y lo sagrado. Morfología de la ciudad occidental." Geographicalia, no. 74 (December 30, 2022): 157–60. http://dx.doi.org/10.26754/ojs_geoph/geoph.2022747108.

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41

Antoine, Jean-Pierre. "Compte rendu de Michel Oury : «Chasseur de comètes : la quête de nos origines»." Revue des questions scientifiques 192, no. 3-4 (2021): 481–82. http://dx.doi.org/10.14428/qs.v192i3-4.72263.

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42

Thaler, Lotte. "Der reine Irrsinn." Opernwelt 65, no. 9-10 (2024): 26–28. http://dx.doi.org/10.5771/0030-3690-2024-9-10-026.

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Mit «Comte Ory» und der «L’italiana in Algeri» huldigt das Rossini-Festival in Bad Wildbad dem großen Komponisten. Auch wird seine Sonderstellung gezeigt: Michele Carafa kommt mit seiner Oper «Masaniello» einfach nicht an ihn heran. VON LOTTE THALER

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ARGYROS, IOANNIS K. "ON THE SOLUTION OF EQUATIONS WITH NONDIFFERENTIABLE OPERATORS." Tamkang Journal of Mathematics 24, no. 3 (1993): 237–49. http://dx.doi.org/10.5556/j.tkjm.24.1993.4495.

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We approximate solutions_of equations with nondifferentiable operators using the Newton-Kantorovich method and the majorant the ory. Under some as easy to verify assumptions as the ones given by Zabrejko and Nguen in [9] we improve their error estimates.

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Bose, Prithviraj, and Marina Y. Konopleva. "ORY-1001: Overcoming the Differentiation Block in AML." Cancer Cell 33, no. 3 (2018): 342–43. http://dx.doi.org/10.1016/j.ccell.2018.02.014.

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45

Bruneau, Michel, and Frédéric Giraut. "Qu’est-ce qu’une nation ? de Pascal Ory, 2020." L’Espace géographique Tome 51, no. 3 (2024): 275–81. http://dx.doi.org/10.3917/eg.513.0275.

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46

Xu, Fuyi, and Jian Liu. "Symmetric Positive Solutions for Nonlinear Singular Fourth-Order Eigenvalue Problems with Nonlocal Boundary Condition." Discrete Dynamics in Nature and Society 2010 (2010): 1–16. http://dx.doi.org/10.1155/2010/187827.

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We investigate nonlinear singular fourth-order eigenvalue problems with nonlocal boundary conditionu(4)(t)-λh(t)f(t,u,u′′)=0,0<t<1,u(0)=u(1)=∫01a(s)u(s)ds,u′′(0)=u′′(1)=∫01b(s)u′′(s)ds, wherea,b∈L1[0,1],λ>0,hmay be singular att=0and/or1. Moreoverf(t,x,y)may also have singularity atx=0and/ory=0. By using fixed point theory in cones, an explicit interval forλis derived such that for anyλin this interval, the existence of at least one symmetric positive solution to the boundary value problem is guaranteed. Our results extend and improve many known results including singular and nonsingular cases. The associated Green's function for the above problem is also given.

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Calvo Carilla, José Luis. "Sobre el "Aullido" de Ginsberg y el grito de Miguel Labordeta." Tropelías: Revista de Teoría de la Literatura y Literatura Comparada, no. 7 (October 18, 2020): 60–74. http://dx.doi.org/10.26754/ojs_tropelias/tropelias.202074652.

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Este artículo estudia los vínculos entre el poeta de la Beat Generation Allen Ginsberg y la poesía española de los años sesenta, atendiendo sobre todo al papel que jugaron en ella los poetas Carlos Edmundo de Ory y Miguel Labordeta.

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48

Dilson, Arman, Nelfira, and Rosda Syelly. "Implementasi Metode Analytic Network Process Dalam Menetapkan Beasiswa Program Indonesia Pintar Menggunakan Superdecission." Technologica 1, no. 2 (2022): 19–32. http://dx.doi.org/10.55043/technologica.v1i2.44.

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Untuk menghindari kesalahan dalam menetapkan penerima Beasiswa Program Indonesia Pintar (PIP) diperlukan sebuah metode yang cocok untuk memutuskan siswa yang berhak menerima beasiswa PIP tersebut. Tujuan penelitian adalah menentukan siswa penerima beasiswa PIP menggunakan metode Analytic Network Process (ANP) yang diimplementasikan menggunakan sistem penunjang keputusan open source (superdecission). Data diperoleh secara langsung pada SMPN 1 Batang Anai melalui tanya jawab dengan bagian keuangan menggunakan kuisioner. Kriteria yang menjadi pertimbangan dalam pengambilan keputusan adalah 1) pekerjaan orang tua, 2) pendapatan orang tua,3) rata-rata nilai raport, dan 4)jumlah tanggungan. Dengan menentukan nilai perbandingan masing-masing kriteria, menetapkan nilai rata-rata, dan menentukan bobot akhir dengan perhitungan menggunakan superdecission, maka dapat ditentukan 5 orang siswa penerima beasiswa PIP secara berurut adalah 1) OR1 (35%), 2) OR3 (35%), 3) OR5 (35%), 4) OR2 (27%), dan 5) OR6 (27%).

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Ibanez, Vinzon, Kestis Vaitkus, Robert Molokie, Yogenthiran Saunthararajah, and Donald Lavelle. "Effect of the Oral LSD1 Inhibitor Ory-1001 on F-Retics in Baboons ( Papio anubis)." Blood 142, Supplement 1 (2023): 1109. http://dx.doi.org/10.1182/blood-2023-189523.

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Elevated levels of Fetal Hemoglobin (HbF) reduce the severity of symptoms and increase life span in patients with sickle cell disease (SCD). Experiments performed in baboons ( P. anubis) have been instrumental in discovering the potent pharmocological agents that increase HbF in vivo. Experimental baboon studies have been directly translated to clinical trials in patients with sickle cell disease. Drugs such as DNMT1 and LSD1 inhibitors that attack the repressive epigenetic regulatory mechanisms that silence expression of the γ-globin gene in adult erythroid cells increase HbF in baboons to levels necessary to provide therapeutic relief in SCD patients. Dose-dependent adverse events associated with the use of these drugs are minimized by modifications of dose and schedule as shown by a clinical trial of oral THU-decitabine in 25 SCD patients (Molokie et al, Plos Med 2017;14(9):e10022382). Our recent results have shown that subcutaneous administration of the DNMT1 inhibitor decitabine and the LSD1 inhibitor RN-1 2d/week produced synergistic increases in F-retics, F cells and γ-globin mRNA in normal baboons and increased HbF to therapeutic levels in phlebotomized anemic baboons after administration of only four doses (Ibanez et al, Blood Adv 2023;7(15):3891-3902). The goal of this current study is to develop an oral combinatorial drug regimen using THU-decitabine and the LSD1 inhibitor ORY-1001 that could be directly translated to clinical trials. Our previous studies demonstrated the effectiveness of oral THU-decitabine to increase HbF levels in baboons (Lavelle et al, Blood 2012;119(5):1240-1247). In this study we have performed 16 dose-response experiments in baboons to test the effect of oral ORY-1001 at doses ranging between 8 and 24µg/kg/d. ORY-1001 was chosen because it exhibited a good safety profile with known pharmacokinetic and pharmacodynamic parameters in a recent study in patients with relapsed/refractory acute myeloid leukemia (Salamero et al, J Clin Oncol 2020; 38(36):4260-4273). Four doses were tested (24µg/kg, n=2; 16µg/kg n=4; 12µg/kg, n-=7; 8µg/kg, n=3). The drug was administered on a single day to facilitate further combinatorial studies with THU-decitabine. Preliminary data from a current clinical trial of THU-decitabine in SCD patients (NCT04055818) suggests that administering the drug on a 1d per week schedule effectively increased HbF levels in patients. ORY-1001 was administered by gavage on a single day (d1) and the effect on F-retics measured by flow cytometry in peripheral blood samples obtained daily between days 6 and 10. The peak F-retic response was observed on d8. A linear dose-response relationship on F-retics was observed (Figure 1, r=0.79). Complete blood counts (CBC) were also performed daily between d6 and d10. Adverse hematological effects were not observed with no incidences of neutropenia or thrombocytopenia (Table 1). No consistent effects on reticulocyte counts were observed (Table 1). These results show that a single oral dose of ORY-1001 is sufficient to increase HBF in baboons without any adverse hematological effects and provide the necessary dose-response data to pursue further combinatorial studies with oral THU-decitabine

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Delgado, Arturo. "A propósito de "Le comte Ory": Farmoutier, Rossini, Mozart." Epos : Revista de filología, no. 8 (August 29, 1992): 485. http://dx.doi.org/10.5944/epos.8.1992.9790.

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