Dissertations / Theses on the topic 'Osteíte'
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Castro, Gláucio Ricardo Werner de. "Avaliação clínico laboratorial e imunogenética de pacientes com doença óssea de Paget." reponame:Repositório Institucional da UFSC, 2014. https://repositorio.ufsc.br/xmlui/handle/123456789/129243.
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Introdução: Muitos aspectos da etiopatogênese da doença óssea de Paget ainda estão por ser elucidados, incluindo seus fatores causais, os motivos de acometer alguns ossos e poupar outros e os fatores determinantes da variabilidade de sua distribuição geográfica. Métodos: Portadores de doença óssea de Paget foram comparado com controles portadores de osteoartrite para avaliar diferenças nas concentrações séricas das citocinas: TNFa, IL1B, IL-6 e IL-17. Em outro protocolo, portadores de doença óssea de Paget foram comparados com controles portadores de osteoartrite para avaliar diferenças nas concentrações séricas dos biomarcadores de metabolismo ósseo: RANKL, osteoprotegerina, DKK-1, sFRP-1 e osteopontina. Para avaliar a presença de mutações genéticas associadas à doença óssea de Paget, portadores de doença óssea de Paget foram avaliados quanto à presença de polimorfismos genéticos dos genes: sequestossomo 1 (SQSTM1), VCP, TNFRSF11B e TNFRSF11A. A qualidade de vida e seus fatores determinantes foram avaliadas com as os questionários de qualidade de vida SF-36 e WHOQOL-bref. Resultados: Portadores de doença óssea de Paget apresentaram concentrações séricas aumentadas de IL-6 (p<0,05) e concentrações séricas reduzidas de IL-17 (p<0,05) quando comparados com o grupo controle. Os pacientes apresentaram concentrações séricas mais elevadas de osteopontina em comparação aos controles (p<0,05). Além disso, as concentrações de osteopontina e fosfatase alcalina óssea se correlacionaram à atividade e à extensão da doença (p<0,05). Quinze sujeitos (20,8%) apresentavam mutações no exon 8 do gene SQSTM1, oito (11,1%) apresentaram a mutação Pro392Leu, e os restantes apresentavam uma mutação ainda não descrita na literatura, Thr430Pro. Os únicos parâmetros significativamente associados à pior qualidade de vida foram: dor óssea, deformidades e estado civil (p<0,05). Conclusão: O presente estudo demonstrou pela primeira vez concentrações reduzidas de IL-17 e aumento das concentrações de osteopontina em portadores de doença óssea de Paget. Além disso, foi encontrada uma mutação do gene SQSTM1 até então inédita na literatura médica.
Abstract : Many aspects of Paget's Disease of Bone (PDB) are still unknown, including its cause, the reasons for its bone distribution and the what determines is geographic distribution. Methods: Patients with PDB were compared with controls with primary osteoarthritis to evaluate possible differences in levels of pro-inflammatory cytokines: TNFa, IL1B, IL-6 and IL-17. In another protocol, patients with PDB were compared with controls with primary osteoarthritis to evaluate possible differences in levels of RANKL, osteoprotegerin, DKK-1, sFRP-1, osteopontin. Polymorphism of the following genes: SQSTM1, VCP, TNFRSF11B and TNFRSF11A were evaluated in PDB patients. To evaluate quality of life and determinant parameters, PDB patients answered to Brazilian versions of SF-36 and WHOQOL questionnaires. Results: Patients with PDB presented higher levels of IL-6 (p<0.05) and lower levels of IL-17 (p<0.05) in comparison to controls. PDB patients presented higher levels of osteopontin in comparison to controls (p<0.05). Moreover, osteopontin and BAP were correlated to disease activity and extension (p<0.05). Fifteen subjects (20.8%) carried mutations in exon 8 of ths SQSTM1 gene, eight (11.1%) carried the Pro392Leu mutation, while the remainders presented a previously undescribed mutation, Thr439Pro. The only parameters significantly associated to quality of life were: bone pain, deformities and marital status (p<0.05). Conclusion: The present study has demonstrated lfor the first time low levels of IL-17 and high levels of osteopontin in PDB patients. Besides, a previously not described mutation of the SQSTM1 gene were found.
Preis, Cássio. "Método de dinamometria isocinética para diagnóstico complementar na osteíte púbica asséptica não traumática / Cássio Preis ; orientadora, Vera Lúcia Israel ; co-orientadora, Elisângela Ferreti Manfra." reponame:Biblioteca Digital de Teses e Dissertações da PUC_PR, 2006. http://www.biblioteca.pucpr.br/tede/tde_busca/arquivo.php?codArquivo=502.
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A descoberta de patologias enfrenta longa jornada de acertos e erros para finalmente atingir a maneira mais correta de tratamento. Talvez o entendimento para conhecer a patofisiologia seja o caminho mais difícil e mais importante visando sua cura. A Osteí
GELORMINI, PASCALE. "Osteite mycotique du massif facial." Nice, 1988. http://www.theses.fr/1988NICE6562.
Full textPetit, Marie-Laure. "Osteite a nocardia : a propos d'un cas." Dijon, 1994. http://www.theses.fr/1994DIJOM045.
Full textFerreira, Fábio Daniel da Cruz. "Inspeção sanitária de ungulados e aves: eficácia do método de inspeção visual em suínos." Master's thesis, Universidade de Évora, 2018. http://hdl.handle.net/10174/23984.
Full textHA-QUANG, KHOI. "Localisation osseuse de la fievre q ? : a propos d'un cas." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX20039.
Full textNASSER-EDDINE, MOHAMED. "Osteite a kingella kingae chez un enfant : a propos d'un cas." Amiens, 1988. http://www.theses.fr/1988AMIEM028.
Full textFredouelle-Lepinay, Marie-Odile. "Contribution a l'etude des infections humaines a yersinia pseudotuberculosis : a propos de trois septicemies et d'une osteite." Angers, 1988. http://www.theses.fr/1988ANGE1046.
Full textMENTRE, ARNAUD. "Le sapho : a propos de 8 observations." Lille 2, 1993. http://www.theses.fr/1993LIL2M321.
Full textFUHRMANN, MARC. "Apport de l'irm dans le diagnostic et le suivi evolutif des infections osseuses des membres." Lyon 1, 1992. http://www.theses.fr/1992LYO1M065.
Full textSedaghat, Hamid. "Ostéite staphylococcique du calcaneum : étude à propos d'un cas." Montpellier 1, 1988. http://www.theses.fr/1988MON11207.
Full textSCHUMACHER, JULIETTE, and ABDELALI YAHIA. "L'osteome osteoide : a propos de dix-sept cas." Lille 2, 1990. http://www.theses.fr/1990LIL2M163.
Full textFaure, Patrick. "L'ostéome ostéoi͏̈de, du diagnostic au traitement." Montpellier 1, 1988. http://www.theses.fr/1988MON11242.
Full textWoehl, Jean-Marie. "Le syndrome synovite-acné-pustulose-hyperostose-ostéite : à propos de 3 observations personnelles." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M207.
Full textGUERRERO, CHANTAL. "Osteome osteoide de la main : a propos de six cas." Toulouse 3, 1989. http://www.theses.fr/1989TOU31164.
Full textETHEVE, COLETTE. "L'osteome osteoide : a propos d'une localisation rare : la rotule." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20215.
Full textSteimlé, Pierre-Paul. "Les osteomes osteoides rachidiens : a propos de 9 cas." Université Louis Pasteur (Strasbourg) (1971-2008), 1993. http://www.theses.fr/1993STR1M084.
Full textDemaison, Christine. "Ostéome éthmoïdal compliqué de fistule éthmoïdo-orbitaire : à propos d'un cas." Toulouse 3, 1988. http://www.theses.fr/1988TOU31313.
Full textKoeck, Jean-Louis. "Osteomes osteoides du pied et de la cheville : a propos de 6 observations : avec revue de la litterature." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25383.
Full textDARGELOS, VINCENT. "Osteome osteoide : a propos de 33 cas : interet des techniques de reperage pre et peroperatoire." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25351.
Full textKwiatkowski, Elisabeth. "Osteome osteoide de la base de l'apophyse odontoide : a propos d'une observation." Lille 2, 1992. http://www.theses.fr/1992LIL2M005.
Full textVervoux, Stéphane. "Sinus pilonidal, ostéite chronique et carcinome verruqueux : à propos d'un cas." Bordeaux 2, 1999. http://www.theses.fr/1999BOR2M005.
Full textBrunet, Christine. "Une methode nouvelle de traitement de l'osteome osteoide : la resection percutanee sous controle tomodensitometrique : a propos de 7 cas." Lyon 1, 1990. http://www.theses.fr/1990LYO1M219.
Full textCampagne, Jean-Pierre. "Osteites recurrentes multiples chroniques : revue de la litterature a propos de trois observations." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20821.
Full textCHICOISNE, MARIE-PAUL. "L'imagerie nouvelle de l'osteome osteoide : interet diagnostique et therapeutique : la resection percutanee." Toulouse 3, 1991. http://www.theses.fr/1991TOU31504.
Full textMARLIER, RIO ISABELLE. "Pseudohippocratisme digital, ulcere chronique de jambe, calcinose vasculaire diffuse, et osteite fibreuse en rapport avec une hyperparathyroidie secondaire a l'insuffisance renale." Amiens, 1991. http://www.theses.fr/1991AMIEM122.
Full textKERVENNIC, PASCAL. "Osteome osteoide du col femoral de l'enfant et de l'adolescent : a propos de 7 observations." Reims, 1993. http://www.theses.fr/1993REIMM031.
Full textPompermaier, Matteo. ""Le vin et l'argent" : osterie, bastioni et marché du crédit à Venise au XVIIIe siècle." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR021.
Full textThis thesis analyses the credit market in Venice during the 18th century. An important part of this research focuses on a quite unique credit system, specific to the Venetian context, that was offer through the inns, or osterie, and the bastioni (warehouses where wine was sold) of the city. In 18th century Venice, wine and money were intrinsically linked through the activity of the innkeepers and the bastioneri (the managers of the bastioni), who originally offered their customers a pawnbroking service. They assumed the double roles of suppliers of basic goods and creditors, thereby becoming central economic figures in Venice’s urban context – especially for the members of the poorest classes. One of the most innovative elements of this research lies in the findings regarding the way that interest on loans was collected: creditors benefited from the fact that one-third of the total value of the transaction was paid in wine. The low average value of the loans confirms that this service was mainly aimed at the lower classes of society, the main actors in what has been defined as ‘the handkerchief economy’. Those who benefited the most from this kind of credit arrangement were essentially poor – but not too poor – people, who had only modest reserves of money, and were thus more vulnerable due to the paucity and irregularity of their income. The main objective of this research is twofold: (a) to analyze the credit activity of bastioni and osterie, and (b) to place it in the Venetian urban context. This study analyzed the Venetian credit market as a whole, and then assessed the characteristics and variables that could influence the demand for credit. Moreover, to develop a more complete view of this specific market, all the main components of the credit offer were taken into consideration. In addition to the already mentioned bastioni and osterie, the activities of Jewish bankers in the Ghetto, the monti di pietà situated on the Venetian mainland, as well as those of the notaries and the private lenders, were also analyzed and compared. In this way, it was possible to investigate the existing relationships between the different credit channels, and to determine that they were actually not in competition with one another; rather, it was discovered that they were, in fact, discretely positioned in a distinctly segmented market. This research is relevant to both specialists in Venetian history, and researchers concerned with economic history in other contexts; this study also proposes a new methodology, and a case study, useful for relative comparison by either constituency
Sousa, Maria Helena de. "Efeito do extrato de Schinus terebinthifolius Raddi sobre osteítes induzidas em maxilares de ratos / Maria Helena de Sousa ; orientadora, Marina de Oliveira Ribas." reponame:Biblioteca Digital de Teses e Dissertações da PUC_PR, 2004. http://www.biblioteca.pucpr.br/tede/tde_busca/arquivo.php?codArquivo=50.
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A osteíte alveolar é uma das complicações pós-exodontias que mais trazem transtornos para pacientes e também para profissionais que defrontam com ela. O objetivo da presente pesquisa foi estudar, histologicamente, em ratos, o processo de reparação em feri
RENEVIER, BUISINE CATHERINE. "Un cas rare de syndrome sapho (synovite, acne, pustulose palmo-plantaire, hyperostose, osteite) revele par une periostite des perones : a propos d'une observation personnelle." Lyon 1, 1990. http://www.theses.fr/1990LYO1M084.
Full textAmaral, Augusto Jobim do. "O dispositivo inquisitivo : entre a ostenta??o penal e a est?tica pol?tica do processo penal." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2014. http://tede2.pucrs.br/tede2/handle/tede/4967.
Full textIt would not be objectionable to define the current phase of human development as a moment of vast proliferation of devices. In order to do so, more than necessarily identify perennial lines of inquisitorial tension within the dynamics of the criminal proceedings and punishment, one must define the way which it operates, how it works, what is its function, what it conveys, creates, governs the actions and thoughts, a network built amongst heterogeneous elements which have a strategic function inscribed in the crossroads of the power-knowledge relations - in short, it is suitable to properly elaborate on the operation of what might be called an inquiring device. A philosophy of devices in the field of criminal science, in particular on the life governed by the criminal justice index (and beyond), convenes a chain of interrelated variables that produce certain power and rupture threads. On the fringes, because it is in these connections between violence and law that the historical and political corpus of the inquiring source rests. Thus, to extract unprecedented novelties off the sovereign (procedural) criminal power, it appears, initially, suitable to investigate the lines of enunciation and light that let themselves be cast over a wide object on the field of inquisitorial gears. The other side of this framework shall be given at the prospect of talking about a differentiating module of the inquisitorial power. Advancing on the historicity of the source, in diachronic time, one queries about the core of punishment (the penalty) and its discourses of legitimation, which defer power strategies currently guided by security-populist ordeals in place of a repressive democracy. In a final stage, the gamut of variations of the type of dominant strategy outlined above could also be addressed from the (political) mechanism of evidence. In order to achieve this, the microcosm of the inquiring device can be poured from the open space through the procedural reforms in Brazil, where its splinters are presented, primarily, providing escape threads tensioning the very own accusatory performance in a context of democraticity. Nonetheless, from openings toward a future point of resistance, new regimens are proposed, at a risk, for a new aesthetics of the criminal proceedings.
N?o seria reprov?vel definir a fase atual do desenvolvimento humano como um instante de uma enorme prolifera??o de dispositivos. Para tanto, mais do que necessariamente identificar as linhas perenes de tens?o inquisitorial dentro das din?micas do processo penal e da puni??o, imperativo delimitar como opera, trabalha, para que serve, o que veicula, gera, governa os gestos e pensamentos, uma rede formada entre elementos heterog?neos que possui uma fun??o estrat?gica inscrita no cruzamento das rela??es de saber-poder em suma, cabe elaborar adequadamente sobre o funcionamento daquilo que se poderia denominar dispositivo inquisitivo. Uma filosofia dos dispositivos no campo das ci?ncias criminais, em especial sobre a vida governada no ?ndice processual penal (e para al?m dele), convoca uma cadeia de vari?veis relacionadas entre si que v?o produzindo determinadas linhas de for?a e de rupturas. Nas franjas, pois, destes nexos entre viol?ncia e direito ? que o corpus hist?rico-pol?tico da quest?o do dispositivo inquisitivo repousa. Desta maneira, para se extrair novidades inauditas do limiar do soberano poder (processual) penal, cabe inicialmente investigar as linhas de enuncia??o e de luz que se deixam distribuir sobre um largo objeto de arquivo acerca do dom?nio das engrenagens inquisitoriais. A contraface deste quadro montado ser? dada diante da possibilidade de se falar sobre um m?dulo diferenciador da pot?ncia inquisit?ria. Avan?ando sobre a historicidade do dispositivo, em momento diacr?nico, perquire-se sobre o n?cleo da puni??o (a pena) e seus discursos de legitima??o, os quais delongam estrat?gias de poder atualmente pautadas pela ostenta??o securit?rio-populista em sede de uma democracia repressiva. Em etapa final, a pan?plia de varia??es do tipo de estrat?gia dominante tra?adas anteriormente pode ser enfrentada tamb?m desde o mecanismo (pol?tico) da evid?ncia. Para isto, o microcosmo do dispositivo inquisitivo pode ser vertido desde o local aberto pelas reformas processuais no Brasil, onde os seus estilha?os apresentam-se, fundamentalmente, oportunizando linhas de fuga a tensionar a pr?pria performance acusat?ria num contexto de democraticidade. Enfim, a partir de aberturas em dire??o a um ponto de resist?ncia futuro, arriscam-se novos regime para uma nova est?tica do processo penal.
Vandeventer, Françoise Arnaud. "Les ostéopathies raréfiantes d'origine thyroi͏̈dienne : à propos de 5 observations." Montpellier 1, 1989. http://www.theses.fr/1989MON11182.
Full textLIENS, DANIEL. "Les osteite aseptiques ou amicrobiennes : a propos de 8 observations personnelles et d'une revue de la litterature ; rapports nosologiques avec les spondylarthropathies seronegatives et le sapho." Lyon 1, 1991. http://www.theses.fr/1991LYO1M097.
Full textMondon, Jean-Michel. "Traitement de l’ostéomyélite et de l’ostéite chronique par l'oxygénothérapie hyperbare : expérience de l'île de la Reunion et revue de la littérature." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25326.
Full textLamas, Lara Francisco Javier. "Relación entre la osteítis alveolar y la variación de estrógenos durante el ciclo menstrual en mujeres en edad fértil." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2003. https://hdl.handle.net/20.500.12672/2800.
Full textThe present research evaluated the relationship between alveolar osteitis and “estrogenos” during the menstrual cycle in women between 15 and 35 years old, who were attended at the Alberto Sabogal Sologuren Hospital and Policlinico Chincha in 2002. We obtained a group of 25 patients to make the study, we divide the menstrual cycle in periods, basing in contraceptive method of rhythm, the first period was from the 1rst to the 8th day, the second period was from the 9th to the 19th day, and the third period from the 20 th to the 28 th day, we only include in the study women with a regular cicle (28 +/- 2 days) and that they have not been taken contraceptive pills, we compare the frequency of the alveolar osteitis in the different periods and we found a relation in the normal values of “estrogeno” in these periods. In the results we found a positive relation between the frequency of the alveolar osteitis and the “estrogenos” values in the different periods. Also we found significative differences between the first and the second period, between the third and the second period, but we could not find differences between the first and the third period. So, we finish saying, that the dental extraction should not be program during the second period, that correspond to the ovulation, in which the “estrogenos” are more high in the women body.
Tesis
Carrere, Corine. "Pneumocéphalies secondaires à un ostéome du sinus frontal : à propos de deux cas et revue de la littérature." Montpellier 1, 1996. http://www.theses.fr/1996MON11013.
Full textHamel, Antoine Potel Gilles Caillon Jocelyne. "Contributions cliniques et expérimentales à l'étude des infections ostéo-articulaires de l'enfant." [S.l.] : [s.n.], 2008. http://castore.univ-nantes.fr/castore/GetOAIRef?idDoc=50516.
Full textPetitcol, Nathalie. "Evolution du PSA dans le cancer de la prostate avec ostéose métastasique (stade D2) et sous hormonothérapie." Montpellier 1, 1992. http://www.theses.fr/1992MON11179.
Full textPrado, Sophia de Lucena. "Desigualdade, revolta, reconhecimento, ostenta??o e ilus?o: o processo de constru??o da identidade de jovens em bandidos em uma unidade socioeducativa de interna??o do Distrito Federal." PROGRAMA DE P?S-GRADUA??O EM ANTROPOLOGIA SOCIAL, 2016. https://repositorio.ufrn.br/jspui/handle/123456789/22126.
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Este trabalho ? fruto de uma pesquisa etnogr?fica realizada com jovens autores de atos infracionais em uma Unidade de Interna??o situada no Recanto das Emas ? Distrito Federal. A partir de um assalto que dois jovens praticaram na minha casa passei a tentar compreender o que levava jovens como eles a recorrerem ao crime e o que isso representava para eles, o que acabou se convertendo no objetivo desta pesquisa. Observei, ent?o, que a falta de perspectivas a que muitos jovens est?o submetidos aliada ao fato de serem tratados como bandidos, independentemente de estarem envolvidos com o crime, em decorr?ncia do processo de sujei??o criminal (MISSE,1999), acaba gerando uma revolta e uma demanda por reconhecimento (HONNETH, 2003) t?o latentes a ponto de transformar o crime em uma op??o que faz sentido para eles. Dessa forma, eles negam um pacto social do qual n?o participam e a ele reagem, por quererem incluir-se e n?o conseguirem. Mais do que uma forma de obter lucros patrimoniais, o crime se apresenta como um meio de acessar um universo simb?lico que n?o estaria dispon?vel a eles por outras vias, como a possibilidade de luxar, de ter fama na quebrada, al?m dos ganhos advindos dessa experi?ncia como a adrenalina e o prazer, ainda que moment?neos, e a viv?ncia de uma situa??o em que se est? no poder, sobretudo depois de uma vida de submiss?o. Entretanto, ao optarem por um estilo de vida que ? rejeitado pela ?moral leg?tima dominante?, eles se veem obrigados a desenvolverem in?meras estrat?gias individuais e coletivas para lidarem com ele, como ? o caso das performances que passam a executar durante o crime para manter a sua imagem de bandido.
This work is a result of an ethnographic research made with young authors of illegal acts at an internment unity located in Recanto das Emas ? Distrito Federal. From an assault that two young men practiced in my house I began to try to understand what led young people as they resort to crime and what it represented to them because since that experience I came across perceptions for which had not yet awakened, which ended up becoming the objective of this research. In that context, trying to access the experiential aspects (RIFIOTIS, 2006) of crime, I tried to identify from the point of view of those subjects which were their benefits and which were their searches behind this experience. Then I observed that the missing of perspectives which these young and poor men are submitted allied to the fact of being treated both by society and the State as criminals, regardless of being involved with the crime, as a result of the subjection criminal process as Misse says (1999), puts the crime as something engraved on subjectivity of the agent, end up generating a revolt and a demand of recognition (HONNETH, 2003) as latent to the point of turning the crime into a choice that makes sense to them, although it has a difficult moral justification. In this way, they deny a social pact, which do not participate and react to, because they want to be included and are not able to. More than a way to obtain patrimonial profits, crime presents itself as a means of accessing a symbolic universe that would not be available to them in another way, such as the possibility of luxury and to have a fame in his own place, besides the gains that come from that experience as the adrenaline and pleasure, even if momentary, to live a situation in which you are in power, moreover after a life of submission. However, by choosing a style of life that is rejected by "legitimate dominant moral", they see their selves forced to develop numerous individual and collective strategies to deal with it, as is the case of performances that are run not only during the crime, but even to maintain his image of bandit. It occurs that even if the crime presents itself, initially, as a fight strategy for recognition, it always ends restricted to their peers, reason for which, overtime, the crime starts to be seeing as an illusion.
Metenier, Corinne. "Apports de l'imagerie moderne dans le diagnostic et le traitement de l'ostéome ostéoïde." Montpellier 1, 1992. http://www.theses.fr/1992MON11048.
Full textZávacký, Martin. "Tunel na trase rychlé železnice." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2016. http://www.nusl.cz/ntk/nusl-240102.
Full textBoavida, Leonor Peixoto Pestana. "Rheumatoid arthritis and Paget’s disease of the bone : osteoimmunology and the role of interleukin 6." Master's thesis, 2015. http://hdl.handle.net/10451/25783.
Full textRheumatoid arthritis (RA) is a chronic multisystemic disease, affecting 0.5–1% of the adult population, characterized by synovial and systemic inflammation. Paget’s disease of the bone (PDB) is a chronic metabolic bone disorder, affecting up to 3% of adults over 55 years of age, characterized by areas of increased bone remodelling. In both RA and PDB, excessive local bone resorption and inadequate bone formation result in progressive bone erosions, reflecting the clinical consequence of the close interplay between immune activation and bone metabolism. Although the aetiology of both diseases is still unknown, genetic and environmental factors contribute to a common underlying immune dysregulation. Interleukin-6 plays a dominant role in the pathogenesis of the increased bone resorption observed in both conditions. Understanding the interplay between the immune and skeletal systems may enable further insights into the pathogenesis of bone destruction, as well as serving as new strategy for drug design. This thesis reports the case of a 60-year-old female diagnosed with both RA and PDB. Both pathologies seldom coexist in the same patient, making this case singular not only because of the inherent complexity of the clinical and imaging evaluation, but also for the possibility of a common therapeutic target.
A artrite reumatóide é uma doença crónica multiorgânica que afecta 0.5-1% da população adulta, sendo caracterizada por sinovite e inflamação sistémica. A doença de Paget do osso é uma doença metabólica crónica, afectando até 3% da população com mais de 55 anos, caracterizada por áreas focais de turnover ósseo aumentado. Em ambas, o aumento local da reabsorção óssea e a formação óssea inadequada resultam em erosão óssea progressiva, reflexo clínico da interacção entre a activação imunológica e o metabolismo ósseo. Embora a sua etiologia permaneça desconhecida, factores genéticos e ambientais contribuem para uma desregulação comum do sistema imunológico. A interleucina-6 desempenha um papel preponderante na patogénese da reabsorção óssea que caracteriza as duas patologias. O estudo da intercomunicação entre os sistemas imunológico e esquelético pode estar na base, não só, da compreensão da patogénese da destruição óssea, como também do desenvolvimento de novas estratégias terapêuticas. Esta tese apresenta um caso clínico de uma doente de 60 anos, diagnosticada com artrite reumatóide e doença de Paget do osso. A coexistência de ambas as entidades no mesmo indivíduo é rara, tornando este caso singular, não só pela complexidade da avaliação clínica e imagiológica mas também pela possibilidade de um alvo terapêutico comum.
Miranda, Hugo Licínio Roque. "Hiperparatiroidismo secundário e compromisso neurológico, que relação? : apresentação de um caso de osteodistrofia renal." Master's thesis, 2014. http://hdl.handle.net/10451/24020.
Full textIntroduction: Secondary hyperparathyroidism is the result of failure in one or more components of the calcium homoeostatic mechanism. In the context of Chronic Kidney Disease Mineral and Bone-related Disorder (CKD-MBD), hyperparathyroidism is characterized, in addition to bone changes, by a cutaneous, articular, vascular, valvular and lung involvement. Relevant hormonal and biochemical changes are present in this pathology. Case Report: We report a case of a 48 years old caucasian woman with end-stage renal disease, in which multiple osteolytic lesions, with possible neurologic compromise, were detected in computed tomography. The patient was previously submitted to surgical ablation of a skull lesion, in which giant cell tumor was admitted. With posterior clinical, biochemical and imaging evaluation, late diagnosis of brown tumors in long term secondary hyperparathyroidism was admitted. Conclusion: In patients with clinical and imaging signs of osteolytic lesions, with end-stage renal disease or hyperparathyroidism, brown tumors must be included in differential diagnosis.
Introdução: O hiperparatiroidismo secundário é o resultado da falência de um ou mais componentes dos mecanismos homeostáticos do cálcio. No contexto da “Chronic Kidney Disease Mineral and Bone-related Disorder” (CKD-MBD), o hiperparatiroidismo caracteriza-se, para além das alterações ósseas, por um envolvimento cutâneo, articular, vascular, valvular, pulmonar e por um grande conjunto de alterações hormonais e dos parâmetros bioquímicos. Caso clínico: É apresentado um caso de uma doente de 48 anos, caucasiana, com doença renal crónica terminal e na qual foram detectadas múltiplas lesões osteolíticas, na tomografia computorizada, com risco de fractura óssea e compromisso neurológico. A doente foi previamente submetida a uma ablação cirúrgica a lesão na calote craniana, apresentando histopatologia compatível com tumor de células gigantes. Com posterior avaliação clínica, bioquímica e imagiológica do quadro clínico, foi assumido o diagnóstico tardio de múltiplos tumores castanhos associados a um hiperparatiroidismo secundário prolongado. Conclusão: Em doentes com sinais clínicos e radiológicos de lesões osteolíticas, que apresentam hiperparatiroidismo ou doença renal crónica terminal, os tumores castanhos devem ser incluídos no diagnóstico diferencial.
Simões, Tiago João Ferreira dos Santos Correia. "Avaliação da distribuição relativa e fatores de risco da alveolite na consulta de cirurgia oral da clínica dentária universitária da UCP." Master's thesis, 2014. http://hdl.handle.net/10400.14/15295.
Full textDry socket is one of the most common post-operative complications deriving from dental extraction. This pathology is derived from the disruption of the normal post-extraction healing, which will compromise the normal remodeling and post-extaction bone healing. Although the etiology of this disease is not yet well understood, it is reported that dry socket is the result from disintegration of the blood clot by fibrinolysis mechanisms. There are several definitions proposed for dry socket, however, many authors emphasize the definition presented by Blum (2002), which states that dry socket could be defined as postoperative pain in and around the socket that increases in intensity between the first and third day after tooth extraction, existing partial or total loss of the blood clot in the socket, presenting or not halitosis. The aim of this study is to evaluate the incidence of dry socket in the control of postextractions complications resulting from dental extraction performed in Oral Surgery appointments at the Dental University Clinic of the Catholic University of Portugal – Viseu, as well as the factors associated with its occurrence. During the time of data collection for this study, 134 extractions were included, performed in 87 patients and 3 cases of dry socket were diagnosed, corresponding to an incidence of 2,24 %. These results are comparable to the results of previous studies reported in the literature. It wasn’t possible to accept or reject any of the hypothesis made and therefore it would be necessary to make a longer study with a bigger sample which allows a better risk factors study inherent to dry socket.
TAMPÍROVÁ, Pavlína. "Teorie ukazování s přihlédnutím k výskytu v praxi." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-156248.
Full textSampaio, Ana Rita da Cunha. "Análise da capacidade antissética de esponjas de celulose oxidada em digluconato de clorexidina 0,2% v/v: estudo piloto." Master's thesis, 2020. http://hdl.handle.net/10284/8757.
Full textDental extractions are procedures routinely performed by dentists and in the vast majority of cases it produces no more than a transient discomfort of rapid healing. However, there is no rare occurrence of complications related to tooth extractions. Post-operative com-plications may be local or systemic. The most frequent local infectious complication is alveolitis. There are several types of alveolitis, and the most common is dry alveolitis. The objective of this in vitro pilot study was to evaluate the antiseptic capacity of 3 reab-sorbable hemostatic sponges of oxidised cellulose from distinct trademarks Hemospon®, Spongostan® and Gelatamp®, impregnated in chlorhexidine digluconate of 0.2% v/v. Saliva was collected from 6 volunteers, aged between 23 and 30 years, with evidence of oral health (WHO), with no antibiotic or drug therapeutic history, without active perio-dontal pathology or exodontias. The sponges were impregnated with a solution of 0.2%v/v and placed in the respective tube with 5 ml of saliva. The sampling was per-formed at 0, 24, 48, 72 and 96 hours. The samples were submitted to the method of suc-cessive decimal dilutions and the respective plating was performed in blood agar. After the incubation period, the results were visualized and expressed in Colony Forming Units/mL. Within the limitations of the study design, it was found that chlorhexidine digluconate solution at 0.2% v/v presented bactericidal antissetic capacity and there was a slower disintegration of hemostatic sponges.
Axmanová, Petra. "Divadelní znaky v představení "Škola Malého stromu"." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-296619.
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