Journal articles: 'Osteitis Fibrosa Cystica'

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Gavrić, Nikola. "Osteitis fibrosa cystica generalisata." Scripta Medica 37, no. 2 (2006): 101–3. http://dx.doi.org/10.5937/scrimed0602101g.

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Agstam, Sourabh. "Osteitis fibrosa cystica." Indian Journal of Nephrology 30, no. 6 (2020): 433. http://dx.doi.org/10.4103/ijn.ijn_292_19.

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Cherian, E. T., and K. B. Guttenberg. "Osteitis fibrosa cystica." QJM: An International Journal of Medicine 111, no. 7 (February 5, 2018): 487. http://dx.doi.org/10.1093/qjmed/hcy019.

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Ramon, Andre, and Pierre-Emmanuel Berthod. "Osteitis Fibrosa Cystica." New England Journal of Medicine 382, no. 11 (March 12, 2020): e15. http://dx.doi.org/10.1056/nejmicm1907828.

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Arbault, Anaïs, Paul Ornetti, Davy Laroche, and Pierre Pottecher. "Osteitis fibrosa cystica." Joint Bone Spine 84, no. 2 (March 2017): 229. http://dx.doi.org/10.1016/j.jbspin.2016.02.027.

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Maanaoui, Mehdi, Aghiles Hamroun, Céline Lebas, Rémi Lenain, and Arnaud Lionet. "Osteitis fibrosa cystica von Recklinghausen." Journal of Nephrology 34, no. 3 (February 8, 2021): 925–26. http://dx.doi.org/10.1007/s40620-020-00961-4.

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Seo, D., and Y. Rhee. "Osteitis fibrosa cystica in primary hyperparathyroidism." QJM 108, no. 12 (August 9, 2015): 991. http://dx.doi.org/10.1093/qjmed/hcv144.

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Rodríguez-Gutiérrez, René, and José Miguel Hinojosa-Amaya. "Brown Tumors: Severe Osteitis Fibrosa Cystica." Mayo Clinic Proceedings 90, no. 5 (May 2015): 699–700. http://dx.doi.org/10.1016/j.mayocp.2014.08.025.

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Maanaoui, Mehdi, Aghiles Hamroun, Céline Lebas, Rémi Lenain, and Arnaud Lionet. "Correction to: Osteitis fibrosa cystica von Recklinghausen." Journal of Nephrology 34, no. 3 (March 27, 2021): 959. http://dx.doi.org/10.1007/s40620-021-01038-6.

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Lee, Ja Hyun, Sung Min Chung, and Han Su Kim. "Osteitis Fibrosa Cystica Mistaken for Malignant Disease." Clinical and Experimental Otorhinolaryngology 6, no. 2 (2013): 110. http://dx.doi.org/10.3342/ceo.2013.6.2.110.

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Spaulding, CM, and G. Young. "Osteitis fibrosa cystica and chronic renal failure." Journal of the American Podiatric Medical Association 87, no. 5 (May 1, 1997): 238–40. http://dx.doi.org/10.7547/87507315-87-5-238.

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ARLIEN-SØBORG, ULLA. "Generalized Osteitis Fibrosa Cystica of Uncertain Aetiology." Acta Medica Scandinavica 152, no. 1 (April 24, 2009): 9–12. http://dx.doi.org/10.1111/j.0954-6820.1955.tb05635.x.

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Watson, Carolyn W., Pamela Unger, Mamoru Kaneko, and Jacques L. Gabrilove. "Fine needle aspiration of osteitis fibrosa cystica." Diagnostic Cytopathology 1, no. 2 (April 1985): 157–60. http://dx.doi.org/10.1002/dc.2840010212.

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Thorwarth, M., S. Rupprecht, A. Schlegel, D. Neureiter, and P. Kessler. "Riesenzellgranulom und Osteitis fibrosa cystica bei Hyperparathyreoidismus." Mund-, Kiefer- und Gesichtschirurgie 8, no. 5 (July 29, 2004): 316–21. http://dx.doi.org/10.1007/s10006-004-0556-6.

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Rickes, Steffen. "osteitis fibrosa cystica misdiagnosed as lytic bone metastases." Acta Endocrinologica (Bucharest) 6, no. 2 (2010): 264. http://dx.doi.org/10.4183/aeb.2010.264.

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Leite-Filho, Ronaldo V., Marcele B. Bandinelli, Gabriela Fredo, Matheus V. Bianchi, Alessandra van der lan Fonini, Marcelo M. Alievi, David Driemeier, Saulo P. Pavarini, and Luciana Sonne. "Osteitis fibrosa cystica in a domestic young cat." Journal of Feline Medicine and Surgery Open Reports 1, no. 2 (July 2015): 205511691560755. http://dx.doi.org/10.1177/2055116915607555.

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Sleiman, I., D. Godi, V. Villanacci, G. Pelizzari, and G. P. Balestrieri. "Osteitis fibrosa cystica, coeliac disease and Turner syndrome." Digestive and Liver Disease 36, no. 7 (July 2004): 486–88. http://dx.doi.org/10.1016/j.dld.2004.03.004.

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Shrestha, Sundar K., and A. Tayal. "Generalised osteitis fibrosa cystica due to secondary hyperparathyroidism in chronic kidney disease." Journal of College of Medical Sciences-Nepal 9, no. 1 (January 20, 2014): 60–66. http://dx.doi.org/10.3126/jcmsn.v9i1.9676.

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Secondary hyperparathyroidism is a frequent complication of patients with chronic kidney disease and is characterized by excessive serum parathyroid hormone levels and an imbalance in calcium and phosphorus metabolism. Secondary hyperparathyroidism is the leading cause of renal osteodystrophy and bone disease. Osteitis fibrosa cystica, the classic and former most common osteodystrophy, is mainly caused by high bone turnover secondary to high levels of circulating PTH. Its pathophysiology is mainly due to hyperphosphatemia and vitamin D deficiency and resistance. This condition has a high impact on the mortality and morbidity of dialysis patients Hyperparathyroidism develops early in the course of CKD and becomes more prominent as kidney function declines. However recently, with the technical development of imaging and laboratory screening methods, hypercalcemia due to primary or secondary hyperparathyroidism can often be detected early; as a result the frequency of osteitis fibrosa cystica has declined. Journal of College of Medical Sciences-Nepal, 2013, Vol-9, No-1, 60-66 DOI: http://dx.doi.org/10.3126/jcmsn.v9i1.9676

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Phitayakorn, Roy, and Christopher R. McHenry. "Jaw Tumor: An Uncommon Presenting Manifestation of Primary Hyperparathyroidism." World Journal of Endocrine Surgery 2, no. 1 (2010): 45–50. http://dx.doi.org/10.5005/jp-journals-10002-1021.

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ABSTRACT Introduction To report two unusual cases of primary hyperparathyroidism (HPT) that initially manifested with a “ jaw tumor” and to discuss the clinical implications of a giant cell granuloma vs an ossifying fibroma of the jaw. Material and methods The history, physical examination, laboratory values and the imaging and pathologic findings are described in two patients who presented with a “jaw tumor” and were subsequently diagnosed with primary HPT. The diagnosis and management of osteitis fibrosa cystica and HPT-jaw tumor syndrome are reviewed. Results Patient #1 was a 70-year-old male who presented with hypercalcemia, severe jaw pain, and an enlarging mass in his mandible. Biopsy of the mass revealed a giant cell tumor and he was subsequently diagnosed with primary HPT. A sestamibi scan demonstrated a single focus of abnormal radiotracer accumulation, corresponding to a 13,470 mg parathyroid adenoma, which was resected. Postoperatively, the serum calcium normalized and the giant cell granuloma regressed spontaneously. Patient #2 was a 36-year-old male with four incidentally discovered tumors of the mandible and maxilla, who was diagnosed with normocalcemic HPT and vitamin D deficiency. Biopsy of one of the tumors revealed an ossifying fibroma. Bilateral neck exploration revealed a 2480 mg right inferior parathyroid adenoma, which was resected. Postoperative genetic testing revealed an HRPT2 gene mutation. He subsequently underwent resection of an enlarging ossifying fibroma of the mandible with secondary reconstruction. Conclusions A “jaw tumor” in a patient with primary HPT may be a manifestation of osteitis fibrosa cystica or HPT-jaw tumor syndrome underscoring the importance of biopsy and genetic testing for management and follow-up.

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Maina, Anthony M., and Harry Kraus. "Successful Treatment of Osteitis Fibrosa Cystica from Primary Hyperparathyroidism." Case Reports in Orthopedics 2012 (2012): 1–3. http://dx.doi.org/10.1155/2012/145760.

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Osteitis Fibrosa Cystica (OFC) is defined as the classic skeletal manifestation of advanced primary hyperparathyroidism. With the increased detection by means of routine calcium screening, the clinical profile of primary hyperparathyroidism in Western countries has shifted from symptomatic disease to one with subtle or no specific symptoms (“asymptomatic” primary hyperparathyroidism). The authors describe a classical feature of advanced primary hyperparathyroidism due to a parathyroid adenoma and its successful treatment.

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Gupta, Anju, Mark C. Horattas, Ali Reza Moattari, and Scott D. Shorten. "Disseminated Brown Tumors from Hyperparathyroidism Masquerading as Metastatic Cancer: A Complication of Parathyroid Carcinoma." American Surgeon 67, no. 10 (October 2001): 951–55. http://dx.doi.org/10.1177/000313480106701009.

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Osteitis fibrosa cystica (brown tumors) can be a skeletal manifestation of advanced hyperparathyroidism, including parathyroid cancer. Severe osteitis fibrosa cystica can mimic metastatic bone diseases especially in patients with a history of cancer. Because the treatment and prognosis of these two problems differ greatly considering hyperparathyroidism in the differential diagnosis of patients found to have osteolytic lesions is critical for the appropriate management of these patients. In this case report we describe a patient with a history of renal cell cancer and presumed osteolytic bone metastases. During prophylactic intramedullary rodding to prevent pathologic fracture of her femur she was found to have a benign lesion related to her previously undiagnosed hyperparathyroidism caused by an underlying parathyroid cancer. A detailed review of this disease and the associated bone changes is also included to underscore the importance of an adequate differential diagnosis as well as optimal management. Patients with hypercalcemia or bony lesions should not automatically be treated palliatively for metastatic disease just because of a past medical history of cancer. Hyperparathyroidism is a readily curable problem if properly diagnosed.

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Pierrard, Patricia Luengo, Laura M. Tortolero Giamate, Belén Porrero Guerrero, Joaquín Gómez Ramírez, and Jordi Nuñez Nuñez. "Osteitis Fibrosa Cystica A Rare Presentation of Primary Hyperparathyroidism." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A207—A208. http://dx.doi.org/10.1210/jendso/bvab048.422.

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Abstract Introduction: Osteitis fibrosa cystica (OFC) is the most serious bone involvement of primary hyperparathyroidism (PHPT), it is characterized by subperiosteal resorption, lytic lesions and the appearance of brown tumors; this is why, in some cases, this condition can easily be mistaken for a malignant neoplasm. Its prevalence in developed countries is only 5%. Clinical Case: We present a 58-year-old woman, with no relevant personal history, who came to the emergency room with pain in her right shoulder after an accidental fall on the bus. The humerus radiograph shows a pathological fracture of the right humerus, with significant osteopenia. In the emergency analysis, serum Calcium 13.3 mg / d), Ionic Calcium 7.03 mg / dL, Phosphorus 2.4 mg / dL, Alkaline Phosphatase 248 U / L and normal kidney function stand out. With a diagnosis of severe hypercalcemia, treatment was started in the emergency room with serum therapy (1000 ml of 0.9% physiological saline in 4 hours) and intravenous diuretic treatment (furosemide 40mg) with a decrease in calcemia to 12.8mg / dL. Later, she was admitted to the Internal Medicine hospital ward to perform a differential diagnosis of hypercalcemia secondary to a primary tumor, Multiple Myeloma or Primary Hyperparathyroidism. The study findings are: Calcium metabolism: PTH 660 pg / ml (12 - 65), 25 Hydroxyvitamin D: 14.00. Thyroid ultrasound: Posterocaudal to right thyroid lobe, an area of echogenicity slightly lower than the thyroid is identified, of dimensions not estimated by endothoracic component, which could correspond to a parathyroid adenoma. Body CT: Neck: Heterogeneous nodule dependent on the posterior region of the right thyroid nodule with endothoracic extension. Skeleton: Lytic lesions with a tumor aspect in the humerus, right scapula and bilateral seventh rib and right pubic branch. Skull: Diffuse increase in bone density of the calvaria, showing multiple punctate lytic lesions with a permeative appearance. Bone densitometry: Femur neck: - <1.5, Lumbar spine: - <3.0 With the diagnosis of PHPT causing osteitis fibrosa cystica, surgical intervention was decided. Under general anesthesia, a selective right approach was performed, finding a large parathyroid adenoma weighing 17 grams. PTH fell to 36 pg / ml after surgery. At 9 months after surgery, the patient presented calcium levels of 9 mg / dl and PTH 146 pg / ml with clear radiological improvement. Discussion: Osteitis fibrosa cystica is rare in our environment, it is often confused with other neoplasms. After parathyroidectomy, patients with PHPT have a marked and sustained recovery from OFC, although in some cases this recovery can only be achieved after several years. We consider this case of interest, since it illustrates the importance of evaluating the study of phospho-calcium metabolism and parathyroid function in all patients with bone lesions to rule out Primary Hyperparathyroidism with OFC.

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Rivas-Prado, Luis, Alejandro Morales-Ortega, Sonia Allodi-de la Hoz, and David Bernal-Bello. "Hyperparathyroidism shows its hand: findings of osteitis fibrosa cystica." Lancet 397, no. 10288 (May 2021): 1914. http://dx.doi.org/10.1016/s0140-6736(21)00796-0.

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Swarnkar, Manish. "Osteitis Fibrosa Cystica: A Forgotten Entity of Primary Hyperparathyroidism." World Journal of Endocrine Surgery 12, no. 2 (2020): 98–100. http://dx.doi.org/10.5005/jp-journals-10002-1290.

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Bains, Margaret A., Linda E. Pardoe, and Claudius E. Rudin. "Osteitis fibrosa cystica and secondary hyperparathyroidism in multiple myeloma." British Journal of Haematology 136, no. 2 (January 2007): 179. http://dx.doi.org/10.1111/j.1365-2141.2006.06315.x.

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Bassler, Thomas, Edward T. Wong, and Russell K. Brynes. "Osteitis Fibrosa Cystica Simulating Metastatic Tumor:An Almost-Forgotten Relationship." American Journal of Clinical Pathology 100, no. 6 (December 1, 1993): 697–700. http://dx.doi.org/10.1093/ajcp/100.6.697.

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Carsote, Mara, Anda Dumitrascu, Claudiu Tupea, Ana Valea, Marian Romeo Smarandache, Marioara Cristina Corneci, Dumitru Ioachim, and Monica Livia Gheorghiu. "Primary hyperparathyroidism - related osteitis fibrosa cystica: Exceptional finding nowadays." Bone Reports 13 (October 2020): 100619. http://dx.doi.org/10.1016/j.bonr.2020.100619.

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Gibbs, C. J., J. G. Millar, and J. Smith. "Spontaneous healing of osteitis fibrosa cystica in primary hyperparathyroidism." Postgraduate Medical Journal 72, no. 854 (December 1, 1996): 754–57. http://dx.doi.org/10.1136/pgmj.72.854.754.

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Luzuriaga, Maria Gracia, Elsie Diez-Cardona, and Violet S. Lagari-Libhaber. "Osteitis Fibrosa Cystica: An Unusual but Still Prevalent Manifestation of Uncontrolled Secondary Hyperparathyroidism." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A208—A209. http://dx.doi.org/10.1210/jendso/bvab048.423.

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Abstract Background: Osteitis fibrosa cystica is an uncommon complication of untreated secondary hyperparathyroidism in patients with end-stage renal disease. The characteristic bony lesions that are seen in this condition very rarely can regress after medical treatment or parathyroidectomy. Clinical Case: A 65-year-old male with PMH of Systemic Lupus Erythematous (SLE) resulting in End-Stage Renal Disease (ESRD) on peritoneal dialysis (PD) and HTN, presented to his primary care physician for evaluation of a painful, enlarging lesion in his left forearm. The patient reported no history of trauma and denied having systemic symptoms. An X-Ray of his left forearm showed a lytic lesion within the proximal neck of the ulna, with erosion of the adjacent cortex. CT of the forearm showed a very vascular soft tissue mass causing significant erosive changes of the anterior cortex in the proximal ulna. Due to the characteristics of the lesion, an underlying malignancy was suspected as a possible diagnosis. The patient had a whole-body PET CT which showed multiple scattered hypermetabolic lytic osseous lesions throughout the axial and appendicular skeleton, including a large left proximal ulnar lesion. The patient had a bone biopsy from the lesion in his left ulna which showed a giant cell proliferation in a background of fibrosis and hemosiderin, suggestive of Osteitis Fibrosa Cystica (brown tumor of hyperparathyroidism). His laboratory workup around the time of the symptoms showed a normal serum calcium (9 mg/dl), associated with a high serum phosphorus (6.2 mg/dl), low vitamin D (20 ng/ml), and an elevated PTH (900 pg/ml). The patient was started on Cinacalcet, an increased dose of phosphate binders, as well as Calcitriol and the lesions and pain disappeared. Follow up lab work showed a normal Vitamin D (34 mg/dl), normal Phosphorus (4 mg/dl), and a PTH of 199 mg/dl, with a normal serum Calcium. A surveillance PET was performed 6 months after the initial one when the lesions clinically had disappeared and it showed again the presence of the bony lesions described prior, including the one in the left ulna, but with decreased FDG uptake, as well as new lesions in the spine. To date, the patient is asymptomatic and has not noted any new painful lesions. Conclusions: Osteitis fibrosa cystica remains a rare manifestation of secondary hyperparathyroidism, which may lead to an initial impression of malignancy. This patient exhibited clinical resolution of the painful symptoms associated with osteitis fibrosa cystica following medical management, though the lytic lesions involving the axial and appendicular skeleton persisted on surveillance imaging. This case serves as a reminder of the severe manifestations of a skeletal disease that has become rare given advances in early detection of and appropriate medical management of hyperparathyroidism.

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Lih, Anna, Mridula Lewis, and John Carter. "A rare case of primary hyperparathyroidism and osteitis fibrosa cystica." Medical Journal of Australia 193, no. 7 (October 2010): 416. http://dx.doi.org/10.5694/j.1326-5377.2010.tb03973.x.

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Misiorowski, Waldemar, Izabela Czajka-Oraniec, Magdalena Kochman, Wojciech Zgliczyński, and John P. Bilezikian. "Osteitis fibrosa cystica—a forgotten radiological feature of primary hyperparathyroidism." Endocrine 58, no. 2 (September 12, 2017): 380–85. http://dx.doi.org/10.1007/s12020-017-1414-2.

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Maturi, Ramesh, Hemanth Makineni, and Sri Santhosh Keerthi Marri. "A Unique Case of Osteitis Fibrosa Cystica with Postoperative Hungry Bone Syndrome and Hypocalcemic Cardiac Failure." World Journal of Endocrine Surgery 7, no. 1 (2015): 10–13. http://dx.doi.org/10.5005/jp-journals-10002-1157.

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ABSTRACT Osteitis fibrosa cystica, a manifestation of severe hyperparathyroidism presenting with crippling bone deformities is a rare presentation these days. We report a case of 40-year-old male patient who presented with generalized aches and pains and bony deformities. Radiographs showed diffuse osteopenia, brown tumors and pathological fractures of phalanges but common manifestations associated with hyperparathyroidism like pancreatic calcifications and nephrolithiasis were absent. Serum calcium and parathyroid hormone levels were elevated while ultrasound imaging of neck showed the presence of a left lower parathyroid adenoma and was confirmed by Tc99- sestamibi scan. Large parathyroid lesion along with high calcium levels and severely elevated PTH puts this patient in high-risk category for postoperative hungry bone syndrome leading to severe hypocalcemia postoperatively. Hypocalcemia usually results in neuromuscular irritability manifesting as paresthesia, Chvostek and Trousseau sign, carpopedal spasm and even convulsions in severe cases. However, our patient had none of the common manifestations, but developed hypocalcemic cardiac failure postoperatively. Case history and management of case is presented. How to cite this article Maturi R, Makineni H, Marri SSK. A Unique Case of Osteitis Fibrosa Cystica with Postoperative Hungry Bone Syndrome and Hypocalcemic Cardiac Failure. World J Endoc Surg 2015;7(1):10-13.

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Nunes, Thaís Borguezan, Sheyla Batista Bologna, Andréa Lusvarghi Witzel, Marcello Menta Simonsen Nico, and Silvia Vanessa Lourenço. "A Rare Case of Concomitant Maxilla and Mandible Brown Tumours, Papillary Thyroid Carcinoma, Parathyroid Adenoma, andOsteitis Fibrosa Cystica." Case Reports in Dentistry 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/5320298.

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Objective.The brown tumour of hyperparathyroidism is a result of a metabolic disorder caused by primary hyperparathyroidism.Report. We described a case of a 37-year-old female patient presenting bimaxillary intraoral lesions and swelling in the neck. Incisional biopsy of the oral lesion was performed and histopathological examination revealed a central giant cell lesion composed by intense haemorrhagic exudate, abundant presence of giant cells, and areas with hemosiderin pigment. The patient also presented high levels of serum calcium and parathyroid hormone, hyperfunctioning parathyroid tissue, bilateral parenchymal nephropathy, and densitometry lower than expected, showing an advanced stage ofosteitis fibrosa cystica. Synchronous parathyroid adenoma and papillary thyroid carcinoma were confirmed by imaging exams and histopathologically.Conclusion.The composition of all the clinical, pathological, and imaging findings led to the final diagnosis of brown tumour of hyperparathyroidism. The occurrence of parathyroid adenoma, papillary thyroid carcinoma, and brown tumours of hyperparathyroidism in their late stage (osteitis fibrosa cystica) associated with oral brown tumours involving the mandible and maxilla is extremely rare.

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Spicher, Rüdiger, Thomas Patzelt, and Hans-Joachim Bauer. "Osteitis fibrosa cystica an der Hand: eine seltene, aber wichtige Differentialdiagnose." Handchirurgie · Mikrochirurgie · Plastische Chirurgie 50, no. 01 (February 2018): 46–47. http://dx.doi.org/10.1055/a-0576-7505.

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EinleitungDer primäre Hyperparathyreodismus ist die zweithäufigste Knochenstoffwechselerkrankung (25–28 auf 100 000/Jahr) nach der Osteoporose 1. In ca. 80 % der Fälle liegt ursächlich ein Nebenschilddrüsenadenom zugrunde. Erhöhte Parathormon-Titer führen durch Osteoklastenaktivierung zu Hypercalci- und Hypophosphatämie 2. Undiagnostiziert und unbehandelt kann es neben vielfältigen anderen Symptomen (z. B. Nierensteine, Magenulcera) zu überschießenden Knochenresorptionen mit Ausbildung von Knochentumoren (sog. „braune Tumoren“) kommen. Diese betreffen gerade auch die Hand und können die Stabilität gefährden. Für die Erkrankung existieren verschiedene Synonyme, so u. a. „Osteodystrophia fibrosa“ oder im englischen Sprachraum „von-Recklinghausen`s disease of bone“.

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Mellouli, Nour, Raouaa Belkacem Chebil, Marwa Darej, Yosra Hasni, Lamia Oualha, and Nabiha Douki. "Mandibular Osteitis Fibrosa Cystica as First Sign of Vitamin D Deficiency." Case Reports in Dentistry 2018 (2018): 1–5. http://dx.doi.org/10.1155/2018/6814803.

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Introduction. Brown tumors of hyperparathyroidism are locally destructive bone lesions. They are the late clinical consequence of the disease. They can occur in primary, secondary, and rarely tertiary forms. They affect usually long bones and less frequently those of the maxilla. Case Report. Our 45-year-old female patient presented with a mandibular tumor next to the first right lower molar. At first, we have chosen tooth extraction and tumor excision. When the histological report showed the giant cell tumor we suspected a metabolic bone disorder. Biochemical tests screened hyperparathyroidism and severe vitamin D deficiency, and parathyroid scintiscan revealed parathyroid adenoma. Discussion. The association of hyperparathyroidism and vitamin D deficiency leads to diagnostic uncertainty. First, secondary hyperparathyroidism can be due vitamin D deficiency. Second, data available show that vitamin D deficiency is more prevalent in patients with primary hyperparathyroidism than in general population. Hyperparathyroidism management is based on correct and precise diagnosis. Furthermore, the resolution of brown tumors depends on the cure of hyperparathyroidism. In fact, bone lesions should regress after biological tests’ normalization. Conclusion. Clinicians should be aware of such rare and complicated presentation. They must consider the diagnosis of the brown tumor to avoid extensive surgical excision and teeth extractions.

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Kulak, C. A. M. "Marked Improvement in Bone Mass after Parathyroidectomy in Osteitis Fibrosa Cystica." Journal of Clinical Endocrinology & Metabolism 83, no. 3 (March 1, 1998): 732–35. http://dx.doi.org/10.1210/jc.83.3.732.

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Rubin, Mishaela R., Virginia A. LiVolsi, Francisco Bandeira, Gustavo Caldas, and John P. Bilezikian. "Tc99m-Sestamibi Uptake in Osteitis Fibrosa Cystica Simulating Metastatic Bone Disease." Journal of Clinical Endocrinology & Metabolism 86, no. 11 (November 2001): 5138–41. http://dx.doi.org/10.1210/jcem.86.11.7994.

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Parra Ramírez, Paola Andrea, Beatriz Lecumberri Santamaría, Cristina Álvarez Escolá, and Luís Felipe Pallardo Sánchez. "Primary hyperparathyroidism with osteitis fibrosa cystica mimicking a malignant bone tumor." Endocrinología y Nutrición (English Edition) 60, no. 2 (February 2013): 96–98. http://dx.doi.org/10.1016/j.endoen.2012.02.007.

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Holzgreve, Adrien, Matthias P. Fabritius, Thomas Knösel, Lena M. Mittlmeier, Johannes Rübenthaler, Reinhold Tiling, Christoph J. Auernhammer, Peter Bartenstein, and Marcus Unterrainer. "Molecular Imaging with 18F-FDG PET/CT and 99mTc-MIBI SPECT/CT in Osteitis Fibrosa Cystica Generalisata." Diagnostics 11, no. 8 (July 28, 2021): 1355. http://dx.doi.org/10.3390/diagnostics11081355.

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Benign so-called “brown tumors” secondary to hyperparathyroidism are a rare diagnostic pitfall due to their impressively malignant-like character in various imaging modalities. We present the case of a 65-year-old male patient with multiple unclear osteolytic lesions on prior imaging suspicious for metastatic malignant disease. Eventually, findings of 18F-FDG PET/CT staging and 99mTc-MIBI scintigraphy resulted in revision of the initially suspected malignant diagnosis. This case illustrates how molecular imaging findings non-invasively corroborate the correct diagnosis of osteitis fibrosa cystica generalisata with the formation of multiple benign brown tumors.

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Priyanthan, Thavathurai, Anne Pernille Hermann, Jonas Asgaard Bojsen, Anne Bruun Krøigaard, Claus Bistrup, and Erik Bo Pedersen. "Multiple Focal Brown Tumors (Osteitis Fibrosa Cystica) in a Renal Transplant Recipient." Case Reports in Nephrology 2022 (March 7, 2022): 1–5. http://dx.doi.org/10.1155/2022/4675041.

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Brown tumors (BTs) are manifestations of osteitis fibrosa cystica that develops due to increased osteoclast activity secondary to hyperparathyroidism (HPTH). The name comes from its characteristic brown color due to high hemosiderin level and hemorrhage surrounded by osteoclastic giant cells, fibrous tissue, and bone fragments. Presentation can be either unifocal or rarely multifocal. Misdiagnosis of BT compared to malignant giant cell tumor is not uncommon. Early diagnosis and intervention may prevent destructive bone changes. Treatment of BTs due to chronic renal failure should be aimed primarily at its prevention with phosphate binders, vitamin D (analogues), calcimimetics, and prolonged dialysis sessions. Parathyroidectomy can be the option in nonresponsive cases. In this report, we present an unusual case of multiple brown tumors in a 54-year-old female renal transplant patient involving the spine, jaw, and scapula, initially misdiagnosed as giant cell tumor. Five years later, the patient was diagnosed with BT because of the medical history, morphology, and negative p63 staining in combination with secondary/tertiary hyperparathyroidism. The patient subsequently underwent subtotal parathyroidectomy.

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Deng, Yan, Xing Shen, Lei Lei, and Wei Zhang. "Osteitis Fibrosa Cystica Caused by Hyperparathyroidism Shown on 18F-NaF PET/CT." Clinical Nuclear Medicine 45, no. 7 (May 22, 2020): 577–79. http://dx.doi.org/10.1097/rlu.0000000000003095.

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Yamaguchi, Tetsuo, Toru Hirano, Kenji Kumagai, Toshiyuki Tsurumoto, Hiroyuki Shindo, Ryuzo Majima, and Nobuyuki Arima. "Osteitis fibrosa cystica generalizata with adult T-cell leukaemia: a case report." British Journal of Haematology 107, no. 4 (December 1999): 892–94. http://dx.doi.org/10.1046/j.1365-2141.1999.01776.x.

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Yamaguchi, Tetsuo. "Osteitis fibrosa cystica generalisata with adult T-cell leukaemia: a case report." British Journal of Haematology 110, no. 4 (September 2000): 757. http://dx.doi.org/10.1046/j.1365-2141.2000.02223.x.

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Kemp, Anna M. Collins, Meliha Bukvic, and Charles D. Sturgis. "Fine Needle Aspiration Diagnosis of Osteitis Fibrosa Cystica (Brown Tumor of Bone)." Acta Cytologica 52, no. 4 (2008): 471–74. http://dx.doi.org/10.1159/000325556.

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Sandoval, M. A. S. "Radiographical appearance of osteitis fibrosa cystica in primary hyperparathyroidism before and after parathyroidectomy." Case Reports 2013, jan29 1 (January 29, 2013): bcr2012008086. http://dx.doi.org/10.1136/bcr-2012-008086.

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Zouaghi, Hela, Dorsaf Touil, and Raouaa Belkacem Chebil. "Brown Tumors of the Mandible Revealing Hyperparathyroidism: About Two Cases." International Journal of Health Sciences and Research 11, no. 12 (December 14, 2021): 128–33. http://dx.doi.org/10.52403/ijhsr.20211218.

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The diagnosis of osteolytic lesions of the jaws can be challenging. Case Reports: Two cases of brown tumor of hyperparathyroidism were reported. A 76- year-old female patient presented with indolent swelling of her right lower jaw measuring approximately 5 cm /6 cm. The panoramic radiograph showed a well-defined osteolytic radiolucency involving the entire mandibular symphysis. Blood investigations revealed High level of parathyroid Hormone (PTH): 102pg/ml. The diagnosis of a brown tumor of hyperparathyroidism was suspected. A parathyroid technetium scintiscan revealed abnormally high uptake at the lower pole of the thyroid lobe interpreted as hyperplasia of right inferior parathyroid gland with possible brown tumor of the mandible. Second case: A 36- year-old female patient presented for the replacement of her missing teeth. Her medical history revealed chronic renal failure and a recent surgical excision of an Osteitis fibrosa cystica of her fifth left proximal phalange. Panoramic radiograph showed multiple well defined osteolytic lesions of the mandible. The diagnosis of a brown tumor of the mandible secondary to hyperparathyroidism was suspected. Laboratory investigations showed increased PTH level, serum hypocalcemia and hyperphosphatemia and vitamin D deficiency. The patient was referred to the department of endocrinology for further investigation and the correction of PTH level. At Six months follow up all the lesions disappeared on radiological control. Discussion: Brown tumor of hyperparathyroidism is a metabolic disorder causing bone resorption that can affect the jaw bones. Clinical symptoms depend on the size and the location of the lesion. Radiographically, it appears as radiolucent unique or multiple well-defined intra-osseous radiolucency. Biological examination is the key to the diagnosis and it is marked by high level of parathyroid hormone (PTH). Key words: Jaw, Tumors, Osteitis Fibrosa Cystica, Hyperparathyroidism, Diagnosis.

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Castellano, Elena, Roberto Attanasio, Alberto Boriano, Valentina Borretta, Marta Gennaro, Adele Latina, and Giorgio Borretta. "RADIOLOGIC MANIFESTATION OF BONE INVOLVEMENT IN PRIMARY HYPERPARATHYROIDISM: PREVALENCE AND CLINICAL SIGNIFICANCE IN A SOUTHERN EUROPEAN SERIES." Endocrine Practice 26, no. 9 (September 2020): 983–89. http://dx.doi.org/10.4158/ep-2020-0095.

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Objective: Clinically overt symptomatic bone disease in primary hyperparathyroidism (PHPT) is rarely seen today, and osteoporosis is the dominant finding. Subperiosteal bone resorption in the fingers and skull mottling are typical bone PHPT findings, the contemporary prevalence of which is unknown. We evaluated these mild lesions and investigated the impact of their occurrence on PHPT clinical management. Methods: We evaluated retrospectively a monocentric series of 363 PHPT patients classified in Group 1 (n = 100) or Group 2 (n = 263) according to the presence or absence of bone involvement, respectively. Patients belonging to Group 1, in turn, were subdivided into Group 1A, with severe and symptomatic lesions (n = 48), and Group 1B, with milder signs of osteitis fibrosa cystica (OFC) without brown tumors or fractures (n = 52). Results: Serum total and ionized calcium, parathyroid hormone, osteocalcin, alkaline phosphatase, and its bone fraction levels were higher in Group 1 than in Group 2, while no gender or age differences were observed between the groups. Osteoporosis prevalence was similar in Group 1B and Group 2 patients but lower than in Group 1A. Mild OFC findings did not modify the surgical indication in any patient of Group 1B. Conclusion: Minor radiologic signs of OFC are not uncommon in the modern PHPT phenotype and occur in patients with more active disease. These signs could identify PHPT patients in an earlier stage of typical bone involvement. However, these features do not seem to upgrade either the clinical classification of asymptomatic PHPT patients or the propensity toward surgical choice. Abbreviations: 25OHD = 25-hydroxyvitamin D; ALP = alkaline phosphatase; bALP = bone-specific alkaline phosphatase; BMD = bone mineral density; eGFR = estimated glomerular filtration rate; OFC = osteitis fibrosa cystica; PHPT = primary hyperparathyroidism; PTH = parathyroid hormone; VF = vertebral fracture

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Mantar, F., S. Gunduz, and U. R. Gunduz. "A Reference Finding Rarely Seen in Primary Hyperparathyroidism: Brown Tumor." Case Reports in Medicine 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/432676.

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Primary hyperparathyroidism is an endocrinopathy which is characterized with the hypersecretion of parathormone. During the progress of the disease bone loss takes place due to resorption on the subperiosteal and endosteal surfaces. Brown tumor is a localized form of osteitis fibrosa cystica, being part of the hyperparathyroid bone disease. It is rarely the first symptom of hyperparathyroidism. Nowadays, the diagnosis is made at an asymptomatic or minimally symptomatic stage. We present a male patient presented with a massive painless swelling in the left maxilla as the first manifestation of primary hyperparathyroidism due to a parathyroid adenoma. Parathyroidectomy was performed, and there was a regression of the bone lesion, without the need of performing other local surgical procedures.

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Bhan, Arti, Dhanwada S. Rao, and Michael Singer. "Abstract #1003260: Osteitis Fibrosa Cystica (OFC) - An Unusual Presentation of Contemporary Primary Hyperparathyroidism (PHPT)." Endocrine Practice 27, no. 6 (June 2021): S96—S97. http://dx.doi.org/10.1016/j.eprac.2021.04.672.

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Agarwal, Gaurav, Saroj K. Mishra, Dilip K. Kar, Anil K. Singh, Vivek Arya, Sushil K. Gupta, and Ambrish Mithal. "Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy." Surgery 132, no. 6 (December 2002): 1075–85. http://dx.doi.org/10.1067/msy.2002.128484.

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Journal articles on the topic 'Osteitis Fibrosa Cystica'

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