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Yang, Tzi-Peng, Hsiao-Mei Chen, Chao-Chin Hu, et al. "Interaction of Osteoarthritis and BMI on Leptin Promoter Methylation in Taiwanese Adults." International Journal of Molecular Sciences 21, no. 1 (2019): 123. http://dx.doi.org/10.3390/ijms21010123.
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Leptin (LEP) regulates glucose metabolism and energy storage in the body. Osteoarthritis (OA) is associated with the upregulation of serum LEP. LEP promoter methylation is associated with obesity. So far, few studies have explored the association of BMI and OA with LEP methylation. We assessed the interaction between body mass index (BMI) and OA on LEP promoter methylation. Data of 1114 participants comprising 583 men and 558 women, aged 30–70 years were retrieved from the Taiwan Biobank Database (2008–2015). Osteoarthritis was self-reported and cases were those who reported having ever been clinically diagnosed with osteoarthritis. BMI was categorized into underweight, normal weight, overweight, and obesity. The mean LEP promoter methylation level in individuals with osteoarthritis was 0.5509 ± 0.00437 and 0.5375 ± 0.00101 in those without osteoarthritis. The interaction between osteoarthritis and BMI on LEP promoter methylation was significant (p-value = 0.0180). With normal BMI as the reference, the mean LEP promoter methylation level was significantly higher in obese osteoarthritic individuals (β = 0.03696, p-value = 0.0187). However, there was no significant association between BMI and LEP promoter methylation in individuals without osteoarthritis, regardless of BMI. In conclusion, only obesity was significantly associated with LEP promoter methylation (higher levels) specifically in osteoarthritic patients.
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Syifaa', Arifah, Zurriyani Zurriyani, and Zuheri Zuheri. "Prevalensi Obesitas terhadap Kejadian Osteoarthritis di Poliklinik Penyakit Dalam RS Pertamedika Ummi Rosnati Banda Aceh." MEDIA KESEHATAN MASYARAKAT INDONESIA 21, no. 3 (2022): 190–95. http://dx.doi.org/10.14710/mkmi.21.3.190-195.
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Latar belakang: Osteoarthritis sering terjadi pada kalangan masyarakat yang dapat menimbulkan nyeri dan kecacatan sehingga menggangu kegiatan sehari-hari. Satu dari beberapa faktor yang menyebabkan perkembangan osteoarthritis yaitu obesitas. Obesitas dapat meningkatkan perkembangan osteoarthritis pada sendi melalui dampak biomekanik dan biokimia. Tujuan dilaksanakannya penelitian ini adalah mengetahui prevalensi obesitas terhadap kejadian osteoarthritis pada pasien osteoarthritis di Poliklinik Penyakit Dalam yang ada di RS Pertamedika Ummi Rosnati Banda Aceh.Metode: Metode observasional deskriptif digunakan di penelitian ini dengan pendekatan cross sectional. Penelitian ini dilaksanakan pada periode Februari - April 2021 menggunakan data primer serta sekunder. Sampel secara total sampling berjumlah 70 responden.Hasil: Hasil penelitian berdasarkan kategori BMI didapatkan jumlah penderita osteoarthritis yang mengalami obesitas sebanyak 49 orang (70%). Penelitian ini menunjukkan bahwa penderita osteoarthritis yang mengalami obesitas, paling tinggi terjadi pada wanita yaitu 43 orang (87,8%), sebagian besar merupakan kelompok usia 50-60 tahun berjumlah 23 orang (46,9%), mayoritas adalah ibu rumah tangga yaitu 33 orang (67,3%), sebagian besar tidak memiliki riwayat genetik sejumlah 31 orang (63,3%), sebagian besar tidak ada riwayat trauma yaitu 35 orang (71,4%), dan sebagian besar mengalami osteoarthritis pada sendi lutut yaitu 35 orang (71,4%).Simpulan: Sebagian besar responden osteoarthritis mengalami obesitas.Kata kunci: Osteoarthritis; ObesitasABSTRACTTitle: Obesity Prevalence on Osteoarthritis Incidence in Internal Medicine Polyclinic of Pertamedika Ummi Rosnati Hospital Banda Aceh.Background: Osteoarthritis often occurs in the community which can cause pain and disability so that it interferes with daily activities. One of several factors that lead to the development of osteoarthritis is obesity. Obesity can promote the development of osteoarthritis by increasing the load on the joints through biomechanical and biochemical impacts. The purpose of this study was to determine the prevalence of obesity on the incidence of osteoarthritis in osteoarthritis patients at the Internal Medicine Polyclinic at Pertamedika Ummi Rosnati Hospital, Banda Aceh. Method:Descriptive observational method used in this study with a cross sectional approach. This research was conducted during the period February-April 2021 using primary and secondary data. The sample in total sampling amounted to 70 respondents. Result:The results of the study based on the BMI category showed that the number of patients with osteoarthritis who were obese was 49 people (70%). This study shows that obese osteoarthritis sufferers, the highest occurred in women, namely 43 people (87.8%), most of them were in the 50-60 year age group totaling 23 people (46.9%), the majority were housewives, namely 33 people (67.3%), most of them did not have a genetic history of 31 people (63.3%), most of them did not have a history of trauma as many as 35 people (71.4%), and most of them had osteoarthritis in the knee joint, namely 35 people (71.4%).Conclusion: Most of osteoarthritis respondent were obese.Keywords: Osteoarthritis; Obesity
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Kulkarni, Kunal, Timothy Karssiens, Vijay Kumar, and Hemant Pandit. "Obesity and osteoarthritis." Maturitas 89 (July 2016): 22–28. http://dx.doi.org/10.1016/j.maturitas.2016.04.006.
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Strebkova, E. A., and L. I. Alekseeva. "OSTEOARTHRITIS AND OBESITY." Rheumatology Science and Practice 53, no. 5 (2015): 542–52. http://dx.doi.org/10.14412/1995-4484-2015-542-552.
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Hawker, Gillian A. "Osteoarthritis & Obesity." Canadian Journal of Diabetes 37 (April 2013): S219—S220. http://dx.doi.org/10.1016/j.jcjd.2013.03.043.
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Anggraini, Niken Enestasia, and Lucia Yovita Hendrati. "The Relation of Obesity and Individual Factors with Knee Osteoarthritis." Jurnal Berkala Epidemiologi 2, no. 1 (2014): 93. http://dx.doi.org/10.20473/jbe.v2i1.2014.93-104.
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ABSTRACTOsteoarthritis represent disease at most found in the world, including in Indonesia. This disease cause pain in bone and disability at patient so disturb everyday activity. One of removed occurrence of knee Osteoarthritis was obesity. Other factors like age, gender, physical activity, and habit smoke were risk factors of knee Osteoarthritis . This research was the relationship of obesitas and individuals factors with occurrence knee osteoarthritis at Surabaya Islamic Hospital. The methods of this research was an observation with case control design. Level of sampel was 64 which consist of 32 case group and 32 control group from incomed patient to radiology unit Islamic Hospital Surabaya for X-Ray photo. The dependent variable was occurence of knee osteoarthritis . The independent variables were obesity, gender, age, physical activity, habit smoke. The instrument used was a questionnaire and form BMI measurement. Data analysis used Chi-Square test with α=0,05 and to know oods ratio (OR) used statclac. The results showed significant relationship between occurence of knee osteoartritis with obesity (p=0,001,OR=7,20), age (p=0,012,OR=3,67) , gender (p=0,005,OR=4,69). For the characteristic of habit smoke (p=0,268,OR=0,56) and physical activity (p=0.919,OR=0,71) were’nt associated with occurence of knee Osteoarthritis at Surabaya Islamic Hospital. The conclusion there is relationship between obesity with knee osteoarthritis at Surabaya Islamic Hospital. Risk factor knee osteoarthritis like gender and age also there were relation with occurence of knee osteoarthritis , for the risk factor of physical activity and habit smoke were’nt relation with occurence of knee osteoarthritis. Keyword : Knee osteoarthritis, obesity, individual factors
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Anggraini, Niken Enestasia, and Lucia Yovita Hendrati. "The Relation of Obesity and Individual Factors with Knee Osteoarthritis." Jurnal Berkala Epidemiologi 2, no. 1 (2014): 93. http://dx.doi.org/10.20473/jbe.v2i12014.93-104.
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ABSTRACTOsteoarthritis represent disease at most found in the world, including in Indonesia. This disease cause pain in bone and disability at patient so disturb everyday activity. One of removed occurrence of knee Osteoarthritis was obesity. Other factors like age, gender, physical activity, and habit smoke were risk factors of knee Osteoarthritis . This research was the relationship of obesitas and individuals factors with occurrence knee osteoarthritis at Surabaya Islamic Hospital. The methods of this research was an observation with case control design. Level of sampel was 64 which consist of 32 case group and 32 control group from incomed patient to radiology unit Islamic Hospital Surabaya for X-Ray photo. The dependent variable was occurence of knee osteoarthritis . The independent variables were obesity, gender, age, physical activity, habit smoke. The instrument used was a questionnaire and form BMI measurement. Data analysis used Chi-Square test with α=0,05 and to know oods ratio (OR) used statclac. The results showed significant relationship between occurence of knee osteoartritis with obesity (p=0,001,OR=7,20), age (p=0,012,OR=3,67) , gender (p=0,005,OR=4,69). For the characteristic of habit smoke (p=0,268,OR=0,56) and physical activity (p=0.919,OR=0,71) were’nt associated with occurence of knee Osteoarthritis at Surabaya Islamic Hospital. The conclusion there is relationship between obesity with knee osteoarthritis at Surabaya Islamic Hospital. Risk factor knee osteoarthritis like gender and age also there were relation with occurence of knee osteoarthritis , for the risk factor of physical activity and habit smoke were’nt relation with occurence of knee osteoarthritis. Keyword : Knee osteoarthritis, obesity, individual factors
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Efendi, Refangga Lova Nusantara, Zulfachmi Wahab, and M. Riza Setiawan. "Central and Peripheral Obesity on Severity Knee Osteoarthritis." MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan 1, no. 3 (2021): 64. http://dx.doi.org/10.26714/magnamed.1.3.2016.64-68.
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Background: Obesity can affect severity of knee osteoarthritis sufferers. Several studies have examined relationship between obesity and osteoarthritis, but no one has examined the different types of obesity on osteoarthritis, therefore, researchers wanted to know differences of central and peripheral obesity on severity osteoarthritis.Methods: A retrospective studi, with cross-sectional, simple random sampling method, conducted between 1 August 2014 and 30 September 2014 in Semarang City. Samples people > 50 years old. Data were analyzed by rank Spearman and Anova correlation.Results: In this study, 45.7% (n = 32) reported severe osteoarthritis. The results of the statistical test obtained p1 = 0,000 (reject Ho). The correlation coefficient (r) is 0.857 (strong), and the linear pattern is positive. The coefficient of determination (r2) is obtained (0.857) 2 = 0.73 = 73%. And 37.1% (N = 26) reported being obese. p2 = 0.043 (reject Ho). The mean deviation (MD) was 0.048 (not significant) between central obesity and peripheral obesity.Conclusion: Obesity affects severity of knee osteoarthritis. The greater body mass index, greater severity of knee osteoarthritis. 73% of severity of knee osteoarthritis is influenced by obesity, but there is no significant effect between central and peripheral obesity on the occurrence of knee osteoarthritis.
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Holubkina, Ye O., and T. M. Tykhonova. "Pathogenetic features in patients with various phenotypic forms of obesity and osteoarthritis: focus on meta-inflammation." Journal of V. N. Karazin Kharkiv National University, Series "Medicine", no. 49 (June 28, 2024): 238–55. http://dx.doi.org/10.26565/2313-6693-2024-49-12.
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Background. Obesity occupies one of the leading places in the structure of non-communicable diseases and according to modern views it is a trigger factor for the occurrence of concomitant pathology, in particular, osteoarthritis. The driving force in osteoarthritis pathogenesis is not only an increase in mechanical load on the joints, but also the production of inflammatory mediators and hormones by adipose tissue, which subsequently leads to metabolic disorders in the osteoarticular system. In regard of the heterogeneity concept of obesity an important task is to study the relationship between the pathogenetic features of various obesity phenotypes and osteoarthritis development. However, despite numerous studies, there are many unresolved questions and controversial points of view on this problem. Purpose – based on the study of literary sources, mainly over the last 10 years, to analyze the pathogenetic features of obesity phenotypes and their relationship with the occurrence and progression of osteoarthritis, as well as to determine the role of inflammation in the structure of these disorders. Materials and Methods. Literature data obtained as a result of an electronic search in the MEDLINE/PubMed, Google Scholar and Web of Science databases using the following Keywords: «obesity», «metabolically healthy obesity», «metabolically unhealthy obesity», «osteoarthritis», «meta-inflammation» was studied and analyzed. Results. Obesity is characterized by a variety of phenotypes, such as: metabolically unhealthy obesity, metabolically healthy obesity, metabolic obesity with normal body weight. While metabolically healthy obesity has more favorable clinical features compared to metabolically unhealthy obesity due to the absence of metabolic disorders and lower levels of inflammatory markers, its verification is complicated with the absence of unified diagnosis criteria. The pathogenesis of osteoarthritis is closely related to obesity: the complex interaction of the metabolic syndrome components leads to the development of chronic low-level inflammation. These processes contribute to disruption of the blood and nerve supply to the joint, synovitis and cartilage destruction thus promoting osteoarthritis onset and progression. Patients with metabolically healthy obesity and metabolic obesity with normal body weight have a lower prevalence of osteoarthritis in comparison with metabolically unhealthy obesity. Conclusions. Involvement of inflammatory factors in the pathogenesis of osteoarthritis and its association with obesity and metabolic syndrome favor the relevance of studying the relationship between obesity and osteoarthritis. However, despite the results of numerous research works related to the influence of metabolic syndrome on the development of osteoarthritis, there is lack of studies on the relationship of osteoarthritis with other phenotypes of obesity, such as metabolically healthy obesity and metabolic obesity with normal body weight. The potential for transition from metabolically healthy to metabolically unhealthy obesity defines metabolically healthy obesity as a transient condition. Regarding this, further study is needed to develop unified and adequate criteria for obesity phenotypes to determine adequate management tactics and prevent the development of its complications and associated musculoskeletal system pathology.
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Marks, Ray. "Obesity, Osteoarthritis and Pain." Advances in Obesity, Weight Management & Control 2, no. 1 (2014): 1–6. http://dx.doi.org/10.15406/aowmc.2014.02.00006.
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Felson, David T. "Obesity and Knee Osteoarthritis." Annals of Internal Medicine 109, no. 1 (1988): 18. http://dx.doi.org/10.7326/0003-4819-109-1-18.
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Lievense, Annet M., Max Reijman, Huibert A. P. Pols, and Sita M. A. Bierma-Zeinstra. "Obesity and hip osteoarthritis." American Journal of Medicine 115, no. 4 (2003): 329. http://dx.doi.org/10.1016/s0002-9343(03)00365-6.
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Coggon, D., I. Reading, P. Croft, M. McLaren, D. Barrett, and C. Cooper. "Knee osteoarthritis and obesity." International Journal of Obesity 25, no. 5 (2001): 622–27. http://dx.doi.org/10.1038/sj.ijo.0801585.
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Berenbaum, Francis, Florent Eymard, and Xavier Houard. "Osteoarthritis, inflammation and obesity." Current Opinion in Rheumatology 25, no. 1 (2013): 114–18. http://dx.doi.org/10.1097/bor.0b013e32835a9414.
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Lee, Ryan, and Walter F. Kean. "Obesity and knee osteoarthritis." Inflammopharmacology 20, no. 2 (2012): 53–58. http://dx.doi.org/10.1007/s10787-011-0118-0.
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Jasiński, Karol, Ewa Dubniewicz, Paula Majewska, et al. "Osteoarthritis in obesity - Summary." Journal of Education, Health and Sport 79 (March 5, 2025): 57898. https://doi.org/10.12775/jehs.2025.79.57898.
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Osteoarthritis (OA) is a slowly progressive joint disease that primarily affects articular cartilage and gradually causes pain, stiffness, and immobility. This problem negatively affects the quality of life of a large part of the population and consumes a significant part of the state budget. It ranks 11th in the list of global health issues in relation to disability. Primary OA occurs due to factors such as age progression, obesity, joint injuries, and anatomical features. Secondary OA frequently associates with other pathologies such as Paget's disease and osteoporosis. Of all the risk factors for KOA (knee osteoarthritis), obesity is the most critical since increasing body weight increases joint stress and hastens cartilage degradation. Weight loss, physical activity, management of symptoms forms in prevention and the management of KOA. Interventions of NSAIDs, glucocorticoids injections, and physiotherapy may help. Total knee arthroplasty remains the most effective treatment for patients with end-stage OA.
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Hardiyanti, Vien, Mariane Devi, I. Made Buddy Setiawan, and Herman P. L. Wungou. "Correlation of Body Mass Index and Kellgren-Lawrence Degrees in Genu Osteoarthritis." SCRIPTA SCORE Scientific Medical Journal 2, no. 1 (2020): 1–5. http://dx.doi.org/10.32734/scripta.v2i1.3369.
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Background: Obesity is a major risk factor for osteoarthritis. Objectives: The aim of this study is to determine the correlation between body mass index with Kellgren-Lawrence degree in genu osteoarthritis patients. Methods: This study used cross-sectional design on 97 participants diagnosed with genu osteoarthritis in Siloam Hospital Kupang in the period January-December 2017. Measurement of height and weight was carried out for the calculation of Body Mass Index. Kellgren-Lawrence degrees were obtained with x-ray photos. Results: Most patients were women (69 patients, 71.7%), 50-59 years old (34 patients, 35.1%), with obesity (61 patients, 62.9%). Conclusion: There was a significant correlation between BMI and Kellgren-Lawrence degree in genu osteoarthritis (p = 0.000). Keywords: BMI, Kellgren-Lawrence, obesity, osteoarthritis genu Latar Belakang: Obesitas merupakan faktor risiko terjadinya osteoartritis pada lutut. Tujuan: Tujuan dari penelitian ini adalah untuk menentukan korelasi indeks massa tubuh (IMT) dengan derajat Kellgren-Lawrence pada pasien penderita osteoartritis genu. Metode: Penelitian ini menggunakan metode cross-sectional yang dilakukan pada 97 responden yang didiagnosis dengan osteoartritis lutut di Rumah Sakit Siloam Kupang pada periode Januari-Desember 2017. Derajat Kellgren-Lawrence ditentukan berdasarkan foto x-ray konvensional. Hasil: Penderita osteoartritis terbanyak adalah perempuan (69 pasien, 71,7%), berusia antara 50-59 tahun (34 pasien, 35,1%), dan dengan IMT kategori obesitas (61 pasien, 62,9%). Kesimpulan: Terdapat korelasi signifikan antara IMT dan derajat Kellgren-Lawrence pada penderita osteoartritis genu. (p = 0,000). Kata kunci: IMT, Kellgren-Lawrence, obesitas, osteoartritis genu
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Elfane, Houda, Mohamed Mziwira, Khadija Sahel, et al. "Association of Obesity with the Lower Limbs Osteoarthritis in a Community of Women from El Jadida Province in Morocco." North African Journal of Food and Nutrition Research 03, no. 05 (2019): 156–63. https://doi.org/10.5281/zenodo.3267465.
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<strong>Background</strong>: In the last years, obesity became of interest because of its association with osteoarthritis (OA) which is increasing with the increase of both life expectancy and the prevalence of obesity. <strong>Aims</strong>: The objective was to assess the association of obesity with the susceptibility of the lower limbs OA (LLOA) occurrence in women. <strong>Subjects and Methods</strong>: The symptomatic susceptibility of the onset of LLOA was evaluated on a sample of women from El Jadida (Morocco) using the Moroccan version of the Western Ontario and McMaster Universities osteoarthritis index (WOMAC) for the lower limbs. Sociodemographic and anthropometric data were collected too using a questionnaire. <strong>Results</strong>: The surveyed female population was 45±13 years old mostly obese (77%) with an average BMI: 29.18 ± 5.29 and a WHR: 0.93 ± 0.9. The susceptibility of the LLOA in both forms (knee and coccyx osteoarthritis) was highly prevalent in women older than 50 years (22%). The three dimensions of WOMAC (pain, stiffness and functional impairment) are felt much more among postmenopausal 44.37±26.67 (with a rate of 49%) than procreating women 29.58±22.44 (with a rate of 51%) among women with morbid obesity (69.40±8.27) than normal weight (31.67±4.40) and in women having android (86.13%) than those with a gynoid obesity morphotype (5.10%). <strong>Conclusions</strong>: The results report an association of obesity with the risk of osteoarthritis occurrence varying with age and OA location hence the importance of preventing osteoarthritis issues through the management of obesity.
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Solov'eva, Inna Vladimirovna, Ekaterina Aleksandrovna Strebkova, Lyudmila Ivanovna Alekseeva, and Ashot Musaelovich Mkrtumyan. "Influence of weight loss on the clinical manifestations of osteoarthritis of the knee-joints." Obesity and metabolism 11, no. 4 (2014): 41–47. http://dx.doi.org/10.14341/omet2014441-47.
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Obesity consistently associated with the development of a number of chronic diseases, leading to a decrease in quality of life, disability and death. The article examines the connection between obesity and disease of the musculoskeletal system, describes the mechanisms by means of which obesity leads to the development of osteoarthritis. It is evident that reduction of body mass can slow the progression of osteoporosis. The own experience of non-pharmacological and pharmacological treatment of obesity with the use of orlistat in 50 obese patients with osteoarthritis of the knee II–III stage is presented. Treatment has resulted in a decrease in body weight, waist circumference, accompanied by a decrease in symptoms osteoarthritis among all the patients. Our results showed that the addition of orlistat to standard osteoarthritis scheme leads to significant reduction in weight and reduction of clinical manifestations of osteoarthritis. According to the above, the drugs that have impact on weight loss, should be included in the treatment regimen of patients with osteoarthritis and obesity.
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Darma, I. Dewa Made Aditya, M. Widnyana, and Putu Ayu Sita Saraswati. "The relationship between obesity and knee osteoarthritis: a literature review." Kinesiology and Physiotherapy Comprehensive 4, no. 1 (2025): 8–14. https://doi.org/10.62004/kpc.v4i1.55.
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Background: Knee osteoarthritis (OA) is an chronic degenerative inflammatory disease of the knee. This study aimed to determine the relationship between obesity and knee OA. Objective: To explore and analyze more deeply the relationship between obesity and knee osteoarthritis. Methods: The research used a literature review design using secondary data in the form of a review of research journals related to obesity and the risk of osteoarthritis. The process of identifying relevant journals was conducted by searching the PubMed and Google Scholar databases using specific keywords such as "obesity," "osteoarthritis," and "knee osteoarthritis OR knee OA”. Six journals that directly addressed the relationship between obesity and knee osteoarthritis were selected for inclusion. These selected journals contained relevant qualitative data and were published within the last 10 years to ensure that the information was up-to-date and applicable to current discussions on the topic. Results: The study results showed a possible association between obesity and knee OA in the elderly, although several factors such as age, gender, and lifestyle also influenced this association. Conclusion: This study concluded that obesity is possibly associated with knee OA, especially in the elderly population. However, further research is needed to validate these findings and address the limitations of existing studies.
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Solov'eva, Inna Vladimirovna, Ekaterina Aleksandrovna Strebkova, Lyudmila Ivanovna Alekseeva, and Ashot Musaelovich Mkrtumyan. "Influence of weight loss on the clinical manifestations of osteoarthritis of the knee-joints." Osteoporosis and Bone Diseases 20, no. 4 (2017): 11–18. http://dx.doi.org/10.14341/osteo12247.
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Obesity consistently associated with the development of a number of chronic diseases, leading to a decrease in quality of life, disability and death. The article examines the connection between obesity and disease of the musculoskeletal system, describes the mechanisms by means of which obesity leads to the development of osteoarthritis. It is evident that reduction of body mass can slow the progression of osteoporosis. The own experience of non-pharmacological and pharmacological treatment of obesity with the use of orlistat in 50 obese patients with osteoarthritis of the knee IIIII stage is presented. Treatment has resulted in a decrease in body weight, waist circumference, accompanied by a decrease in symptoms osteoarthritis among all the patients. Our results showed that the addition of orlistat to standard osteoarthritis scheme leads to significant reduction in weight and reduction of clinical manifestations of osteoarthritis. According to the above, the drugs that have impact on weight loss, should be included in the treatment regimen of patients with osteoarthritis and obesity.
 This article is the PeReint of the original publication in Obesity and Metaboilism (2014) 11(4); pp. 41-47. doi: 10.14341/omet2014441-47
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Elfane, Houda, Mohamed Mziwira, Khadija Sahel, et al. "Association of Obesity with the Lower Limbs Osteoarthritis in a Community of Women from El Jadida Province in Morocco." North African Journal of Food and Nutrition Research 3, no. 5 (2019): 156–63. http://dx.doi.org/10.51745/najfnr.3.5.156-163.
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Background: In the last years, obesity became of interest because of its association with osteoarthritis (OA) which is increasing with the increase of both life expectancy and the prevalence of obesity. Aims: The objective was to assess the association of obesity with the susceptibility of the lower limbs OA (LLOA) occurrence in women. Subjects and Methods: The symptomatic susceptibility of the onset of LLOA was evaluated on a sample of women from El Jadida (Morocco) using the Moroccan version of the Western Ontario and McMaster Universities osteoarthritis index (WOMAC) for the lower limbs. Sociodemographic and anthropometric data were collected too using a questionnaire. Results: The surveyed female population was 45±13 years old mostly obese (77%) with an average BMI: 29.18 ± 5.29 and a WHR: 0.93 ± 0.9. The susceptibility of the LLOA in both forms (knee and coccyx osteoarthritis) was highly prevalent in women older than 50 years (22%). The three dimensions of WOMAC (pain, stiffness and functional impairment) are felt much more among postmenopausal 44.37±26.67 (with a rate of 49%) than procreating women 29.58±22.44 (with a rate of 51%) among women with morbid obesity (69.40±8.27) than normal weight (31.67±4.40) and in women having android (86.13%) than those with a gynoid obesity morphotype (5.10%). Conclusions: The results report an association of obesity with the risk of osteoarthritis occurrence varying with age and OA location hence the importance of preventing osteoarthritis issues through the management of obesity. Keywords: Knee osteoarthritis, Coccyx osteoarthritis, WOMAC, Obesity, BMI, WHR.
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Dedukh, Ninel, Nataliia Zaverukha, Maryna Bystrytska, and Nataliya Yakovenchuk. "Sarcopenia, sarcopenic obesity and osteoarthritis." ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS, no. 3 (October 25, 2021): 101–6. http://dx.doi.org/10.15674/0030-598720213101-106.
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Sarcopenia is considered an important geriatric syndrome, the manifestations of which lead to impaired quality of life and increased mortality. Sarcopenia is a disease associated with decreased muscle mass and strength. Sarcopenic obesity is manifested by an increase in subcutaneous or visceral fat, fatty degeneration of muscles, and is also accompanied by impaired muscle function. After the age of 40, an average of 8 % loss of muscle mass is noted, and by the age of 80 this value can reach 50 %. The review examined the relationship between sarcopenia, sarcopenic obesity, and osteoarthritis (OA).Many exogenous and endogenous factors influence the development and course of OA. Based on the study of mechanisms of cellular and molecular profiles, the specific features for these frequently coexisting pathologies have been identified. The review presents the molecular mechanisms in the development of sarcopenia, sarcopenic obesity and osteoarthritis. Increased fat mass is manifested by increased adipogenesis, expression of inflammatory molecules (leptin, adiponectin, interleukin-1 (IL-1), IL-1b, IL-6 and tumor necrosis factor α) that contribute to chronic low-grade systemic inflammationand negatively affect muscle and joint quality. The relationship between elevated levels of myostatin and muscle weakness as well as myostatin accumulation in synovial fluid and severity of osteoarthritis was considered. Some common mechanisms in the development of sarcopenia and OA were noted: the influence of oxidative stress, systemic chronic inflammation, and disruption of the signaling pathway of bone morphogenetic proteins. Based on the analysis of associations between sarcopenia, sarcopenic obesity, and OA, population-based studies have revealed a high prevalence of knee OA with an increased risk among men with sarcopenic obesity. Women with sarcopenia and sarcopenic obesity had a high risk of knee OA in both groups. The review reviewed the prevention and treatment of the combined pathology, in particular the effect of sarcopenia on the results of total joint а rthroplasty in patients with OA. In general, sarcopenia, sarcopenic obesity, and OA can be considered as concomitant age-associated diseases that jointly affect quality of life and life expectancy.
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Nicolau, Mihaela-Ana. "ADIPOKINES BETWEEN OBESITY AND OSTEOARTHRITIS." Romanian Journal of Rheumatology 24, no. 1 (2015): 14–21. http://dx.doi.org/10.37897/rjr.2015.1.2.
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WAT (white adipose tissue) is considered nowadays a real endocrine organ, which releases an increased number of biomarkers, known as adipokines. These ones have been closely examined during the last decade, as they play an important role in the cartilage homeostasis and they can serve the early diagnosis and the treatment of osteoarthritis.
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Wluka, Anita E., Cate B. Lombard, and Flavia M. Cicuttini. "Tackling obesity in knee osteoarthritis." Nature Reviews Rheumatology 9, no. 4 (2012): 225–35. http://dx.doi.org/10.1038/nrrheum.2012.224.
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Jiang, L., X. Zhu, J. Rong, et al. "Obesity, osteoarthritis and genetic risk." Bone & Joint Research 7, no. 7 (2018): 494–500. http://dx.doi.org/10.1302/2046-3758.77.bjr-2017-0274.r1.
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Objectives Given the function of adiponectin (ADIPOQ) on the inflammatory condition of obesity and osteoarthritis (OA), we hypothesized that the ADIPOQ gene might be a candidate gene for a marker of susceptibility to OA. Methods We systematically screened three tagging polymorphisms (rs182052, rs2082940 and rs6773957) in the ADIPOQ gene, and evaluated the association between the genetic variants and OA risk in a case-controlled study that included 196 OA patients and 442 controls in a northern Chinese population. Genotyping was performed using the Sequenom MassARRAY iPLEX platform. Results The single nucleotide polymorphism (SNP) rs182052 was found to be potentially associated with knee OA risk (additive model: odds ratio = 1.38; 95% confidence interval 1.07 to 1.76; p = 0.012). Furthermore, a non-significant association was observed for rs182052 and body mass index with regard to OA risk in interaction analyses (p = 0.063). Similarly, no significant interaction was detected for rs182052 and age with regard to OA risk (p = 0.614). Conclusion These findings suggest that the SNP rs182052 in the ADIPOQ gene may potentially modify individual susceptibility to knee OA in the Chinese population. Further studies are warranted to investigate our findings in more depth. Cite this article: L. Jiang, X. Zhu, J. Rong, B. Xing, S. Wang, A. Liu, M. Chu, G. Huang. Obesity, osteoarthritis and genetic risk: The rs182052 polymorphism in the ADIPOQ gene is potentially associated with risk of knee osteoarthritis. Bone Joint Res 2018;7:494–500. DOI: 10.1302/2046-3758.77.BJR-2017-0274.R1.
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Gabay, Odile, David J. Hall, Francis Berenbaum, Yves Henrotin, and Christelle Sanchez. "Osteoarthritis and obesity: Experimental models." Joint Bone Spine 75, no. 6 (2008): 675–79. http://dx.doi.org/10.1016/j.jbspin.2008.07.011.
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Shumnalieva, Russka, Georgi Kotov, and Simeon Monov. "Obesity-Related Knee Osteoarthritis—Current Concepts." Life 13, no. 8 (2023): 1650. http://dx.doi.org/10.3390/life13081650.
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The knee is the joint most frequently involved in osteoarthritis and represents a significant contributor to patient morbidity and impaired functional status. Major risk factors include genetics, age, sex, mechanical load and obesity/metabolic syndrome. Recent studies highlighted the role of obesity and metabolic syndrome in the pathogenesis of knee osteoarthritis not simply through increased mechanical loading but the systemic effects of obesity-induced inflammation. The current concept of knee osteoarthritis is that of a ‘whole joint disease’, which highlights the involvement not only of articular cartilage but also the synovium, subchondral bone, ligaments and muscles. Obesity and metabolic syndrome are associated with higher levels of pro-inflammatory cytokines, increased production of adipokines with both protective and destructive effects on articular cartilage, an up-regulation of proteolytic enzymes such as matrix metalloproteinases and aggrecanases and an increase in free fatty acids and reactive oxygen species induced by dyslipidemia. These findings underscore that the adequate management of knee osteoarthritis needs to include an optimization of body weight and a beneficial mobility regimen. The possible introduction of pharmacological therapy targeting specific molecules involved in the pathogenesis of obesity-related osteoarthritis will likely also be considered in future therapeutic strategies, including personalized treatment approaches.
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AL-Barzinjy, Niaz. "Prevalence of Osteoarthritis of Weight Bearing Joints in Relation to Body Weight in Both Genders." Zanco Journal of Medical Sciences 14, no. 1 (2010): 61–66. http://dx.doi.org/10.15218/zjms.2010.010.
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Background and objective: Obesity is an important and increasing public health problem, being a risk factor for overall mortality and major chronic disease. To determine relationship between different measures of body mass index and incidence of hip and knee osteoarthritis in male and female. Methods: Comparison of prevalence of primary osteoarthritis of knee and hip. Between age and sex matched control from out patient clinic of Erbil and Rizgary teaching hospital over period of eleven months starting on Jan 2007.this constituted one hundred and eighty five subjects of normal body `mass index. And one hundred and sixty subjects with high body mass index. Subjects fulfilling our inclusion criteria under went clinical evaluation and radiology of their knee and hip joints, we assessed by chi-squared test, differences in frequency of osteoarthritis between those with normal body mass index and those with high body mass index and between male and female. Results: Obesity was a stronger predictor of osteoarthritis of knee joint with no sex and age difference. In the prevalence of osteoarthritis of hip joint. No link between obesity and hip osteoarthritis was found in this study. Conclusions: Obesity in 35-45 year old men and female will predispose to primary osteoarthritis of the knee.
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Vennu, Vishal, Aqeel M. Alenazi, Tariq A. Abdulrahman, Ahmad S. Binnasser, and Saad M. Bindawas. "Obesity and Multisite Pain in the Lower Limbs: Data from the Osteoarthritis Initiative." Pain Research and Management 2020 (July 10, 2020): 1–7. http://dx.doi.org/10.1155/2020/6263505.
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Background. Although several studies investigated the relationship between obesity, osteoarthritis, and pain, no study examined the association between obesity and multijoint pain in the lower limbs. The purpose of this study was to address this gap. Method. This cross-sectional study was performed in Riyadh, Saudi Arabia, between March and April 2019. In this study, a total of 4,661 adults aged 45–79 years with or at high risk for knee osteoarthritis were included from the Osteoarthritis Initiative. The persons who had an elevated risk of developing symptoms of knee osteoarthritis during the study were defined as high risk for knee osteoarthritis. According to the body mass index, participants were categorized into three groups: normal weight (n = 1,068), overweight (n = 1,832), and obese (n = 1,761). Logistic regression was used to examine the association between obesity and multisite pain. Results. The odds of multisite pain was associated significantly (p<0.001) by 1.36 times higher with obesity than normal weight, no, or sigle-site pain, even after adjusting for sociodemographic and health variables Conclusion. Obesity is associated with an increased likelihood of multisite pain in the lower limbs. The results enable clinicians to adopt better standards of practice for the prevention and screening of multisite pain in this community.
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Ali, Esmail Al-Snafi, Hussein Amer Muayad, and Helal Shnawa Kareema. "Medicinal plants for the treatment of obesity and overweight: A review." World Journal of Biology Pharmacy and Health Sciences 10, no. 2 (2022): 001–10. https://doi.org/10.5281/zenodo.6965518.
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Obesity and overweight have increased and became a major public health problem in the world during the last decades. Obesity and overweight increased the risk of diabetes, heart disease, osteoarthritis, bile diseases and certain cancers. In the current review, PubMed, Web Science, Science Direct, Researchgate, Academia.edu and Scopus were searched to highlight the anti-obesity activities of medicinal plants.
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GANDHI, RAJIV, MARK TAKAHASHI, RANDY RIZEK, OMAR DESSOUKI, and NIZAR N. MAHOMED. "Obesity-related Adipokines and Shoulder Osteoarthritis." Journal of Rheumatology 39, no. 10 (2012): 2046–48. http://dx.doi.org/10.3899/jrheum.111339.
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Stürmer, Til, Klaus-Peter Günther, and Hermann Brenner. "Obesity, overweight and patterns of osteoarthritis." Journal of Clinical Epidemiology 53, no. 3 (2000): 307–13. http://dx.doi.org/10.1016/s0895-4356(99)00162-6.
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Liu, Y., W. Ding, H. L. Wang, et al. "Gut microbiota and obesity-associated osteoarthritis." Osteoarthritis and Cartilage 27, no. 9 (2019): 1257–65. http://dx.doi.org/10.1016/j.joca.2019.05.009.
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Mohamed, Khaled Elhady, Christian S. Thudium, Asger R. Bihlet, et al. "OBESITY – A KEY DRIVER IN OSTEOARTHRITIS." Osteoarthritis and Cartilage 33 (April 2025): S433. https://doi.org/10.1016/j.joca.2025.02.632.
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Hang, Wei, and Birong Zhang. "OSTEOARTHRITIS AND OBESITY: DO FIBROBLASTS MATTER?" Osteoarthritis and Cartilage 33, no. 6 (2025): 779. https://doi.org/10.1016/j.joca.2025.03.021.
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Oguzie, C. G., O. A. Lasebikan, C. J. Onyempka, et al. "Cause and Effect Relationship of Body Weight and Knee Osteoarthritis: Experience from a Tertiary Institution in South-Eastern Nigeria." Journal of BioMedical Research and Clinical Practice 2, no. 1 (2019): 9–13. http://dx.doi.org/10.46912/jbrcp.93.
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It is well established that obesity is related to osteoarthritis of the knees. The aim of this study was to investigate the risk of knee osteoarthritis in relation to body mass index (BMI) and specifically, to assess the risk of knee osteoarthritis (OA) attributable to obesity. We also aimed to determine if there is a higher risk with an increase in BMI. This is an observational case-referent study of patients with knee pain. Patients were recruited from the orthopaedics clinic. The cases were patients that presented with radiologically diagnosed knee osteoarthritis, while the referents were other patients that also attended the orthopedic clinic at the same time. The referents were randomly selected. Body Mass Index was calculated and classified based on the WHO international classification. Data were analyzed using SPSS version 21. A total of 152 patients were included in the study and 67.1% were females while 32.9% were males giving a ratio of 2:1. The mean age was 57.72+/-12.5 years, the mean weight was 79.47+/- 13.41kg (95% CI 77.32 – 81.62) and the mean BMI was 27.80+/-6.2kg/m2. 56.6% had knee osteoarthritis. 8.6% (n = 13) were bilateral, 18.4% (n = 28) in the left knee and 29.6% (n = 45) in the right knee. The relationship between obesity and the presence of knee osteoarthritis was statistically significant (p 0.047). A Chi-squared test for trend also did not show an increased risk for knee osteoarthritis with increasing BMI (p 0.105). In conclusion, knee osteoarthritis is a degenerative joint disease that mostly affects the elderly. Our findings give strong support to the already existing knowledge of the positive relationship between obesity and knee osteoarthritis; however, increasing BMI did not increase the risk of knee OA.
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Misra, Devyani, Roger A. Fielding, David T. Felson, et al. "Risk of Knee Osteoarthritis With Obesity, Sarcopenic Obesity, and Sarcopenia." Arthritis & Rheumatology 71, no. 2 (2019): 232–37. http://dx.doi.org/10.1002/art.40692.
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Shumnalieva, Russka, Georgi Kotov, Plamena Ermencheva, and Simeon Monov. "Pathogenic Mechanisms and Therapeutic Approaches in Obesity-Related Knee Osteoarthritis." Biomedicines 12, no. 1 (2023): 9. http://dx.doi.org/10.3390/biomedicines12010009.
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The knee is the joint most frequently involved in osteoarthritis, a common joint disorder in the adult population that is associated with significant chronic joint pain, reduced mobility and quality of life. Recent studies have established an association between obesity and the development of knee osteoarthritis that goes beyond the increased mechanical load on the knees as weight-bearing joints. This link is based on the maintenance of a chronic low-grade inflammation, altered secretion of adipokines by the adipose tissue and development of sarcopenia. Major adipokines involved in the pathogenesis of obesity-related knee osteoarthritis include adiponectin, which appears to have a protective effect, as well as leptin, resistin and visfatin, which are associated with higher pain scores and more severe structural damage. Joint pain in knee osteoarthritis may be both nociceptive and neuropathic and is the result of complex mechanisms driven by nerve growth factor, calcitonin gene-related peptide and pro-inflammatory cytokines. The role of endogenous cannabinoids and gut microbiota in common mechanisms between obesity and knee pain has recently been studied. The aim of the present review is to highlight major pathogenic mechanisms in obesity-related knee osteoarthritis with special attention on pain and to comment on possible therapeutic approaches.
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Al-Yasseri, Berq J. Hadi, Ayad Ali Radi, and Mohammed Abdul Ridha Abbas. "Assessment of obesity and central obesity among patients with knee osteoarthritis in Al-Sadder Hospital, Baghdad, Iraq." Journal of Ideas in Health 2, no. 2 (2019): 113–17. http://dx.doi.org/10.47108/jidhealth.vol2.iss2.37.
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Background: Obese individuals are at increased risk for many chronic and life-threating conditions. The most significant burden on the musculoskeletal system resulted from osteoarthritis, mainly knee osteoarthritis. This study aimed to determine the prevalence of obesity and central obesity among a group of patients with knee osteoarthritis, analyze the effect of demographic variables, and examine the relationship between these two types of obesity.
 Methods: A cross-sectional study was conducted in Al-Sadder hospital in Baghdad from June through September 2017. A convenience sample of 200 patients with knee osteoarthritis was collected. Those with body mass index (BMI) equal to or more than (30 kg/m2) considered obese. The cutoff point for central obesity was the waist-hip ratio (WHR) above (0.9) for men and above (0.85) for women. The risk ratio and 95% confidence interval (95% CI) calculated to determine the strength of the relationship. P-value ≤ 0.05 was considered statistically significant. 
 Results: The number of obese patients, according to BMI, was 163 (81.5%). For central obesity, the men and women with unhealthy WHR were 53 (96.4%) and 131 (10.3%), respectively. No significant difference in the rate of obesity among age groups (p= 0.986). Central obesity is significantly lower in those less than 45 years (p=0.023). In men, the risk of obese to have central obesity is (1.06) with no significant association (95% CI = 0.89 - 1.27, P = 0.481). In women, risk ratio = 1.56 and association is significant (95% CI = 1.03 - 1.36, P = 0.037).
 Conclusion: The increasing age was associated with a rise in the rate of central obesity, but not with obesity. The overlap between the two types of obesity was evident and significant only in women.
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Himanshu, Bhatt Dhruva, and Amit M. Patel. "Patient-Reported Quality of Care among Osteoarthritis Patients." International Journal of Health Sciences and Research 12, no. 3 (2022): 199–204. http://dx.doi.org/10.52403/ijhsr.20220328.
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Background: Osteoarthritis is a joint disease characterized by pain, disability, and impaired quality of life. Old age, female gender, overweight and obesity, knee injury, repetitive use of joints, bone density, muscle weakness, and joint laxity plays roles in development and risk factors of Osteoarthritis. Knee Osteoarthritis is more important not only for its high prevalence rate compared with other types of Osteoarthritis but also its presentation at earlier age groups particularly in younger age groups of obese women. In order to determine, monitor and improve quality of care, quality indicators based on standards of care may be used. The quality indicators can be used to evaluate whether the patient’s care is consistent with the indicators, and at population levels. This could also be used by healthcare providers to capture individual patient’s need. Methodology: The study design is questionnaire survey, Self-made and pre assessed questionnaire was made .Questions were involved on awareness and knowledge of the disease, physiotherapy treatment, assessment of obesity and its management, assessment and management of external aids, pain assessment and management. 50 participants have participated in survey. Data analysis was done by using Microsoft excel 2019. Result: Data from 50 participants were included for final analysis. The majority of study participants were females (n = 71%, 36). The mean age of participants was 58.3. Quality of care in terms of Knowledge and awareness (Related to Osteoarthritis of knee) Physiotherapy treatment, Assessment and management of obesity, Assessment and management of obesity, Assessment and management of external aids, Assessment and management of pain among osteoarthritis of knee patients regarding was assessed. Conclusion: The study shows fair knowledge and awareness among osteoarthritis of knee patients regarding quality of care. Key words: Quality of care, Osteoarthritis, Questionnaire.
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Lee, Mei-Ling, Xin He, Xiaoxiao Lu, Shuo Chen, and Marc Hochberg. "Association between Obesity, Race and Knee Osteoarthritis: The Multicenter Osteoarthritis Study." International Journal of Statistics in Medical Research 3, no. 3 (2014): 224–30. http://dx.doi.org/10.6000/1929-6029.2014.03.03.2.
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Gulraiz, Gulraiz Enderyas, Sania Rasool Sania, Farooq Islam Farooq, Asim Raza Asim, and Nayab John Nayab. "Obesity and Overweight in Women with Knee Osteoarthritis Secondary to Menopause." Healer Journal of Physiotherapy and Rehabilitation Sciences 2, no. 3 (2022): 197–204. http://dx.doi.org/10.55735/hjprs.v2i3.66.
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Background: Knee osteoarthritis, a degenerative joint disease, causes pain and stiffness in the knee joint, especially in obese people. Obesity is a significant risk factor for knee osteoarthritis. Objective: To estimate the prevalence of obesity and overweight in post-menopausal women secondary to knee osteoarthritis. Methods: This descriptive cross-sectional study was conducted from January to August 2022. A sample of 223 participants was collected from Aziz Bhatti Shaheed hospital Gujrat, tertiary headquarters hospital Lalamusa & Kharian and National orthopedics hospital Gujrat. Non-probability convenient sampling technique was used to recruit women categorized according to the set criteria of body mass index and waist-to-hip circumference ratio. Anthropometric measurements were taken by using a weight machine and measuring tape. Data were analyzed by using SPSS version 24. For descriptive analysis, mean and standard deviations were calculated for quantitative variables whereas frequency and percentages were used for qualitative variables. Results: Results indicate that out of 223 individuals 52% of participants were overweight, 20.2% participants were obese and 27.8 % participants were of normal weight. The mean age of the participants was 64.2±7.66. Age group and family history of knee osteoarthritis are highly associated with the body mass index of the participants (p<0.001). Family history of knee osteoarthritis and waist-to-hip circumference ratio were significantly associated with each other (p<0.001). Conclusion: The prevalence of overweight women is high and the calculated prevalence of obesity in people with knee osteoarthritis is relatively low. These findings are related to the age group and family history of the condition. Thus, obesity and being overweight are major contributors to knee osteoarthritis.
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Wood, G. Craig, Lisa Bailey-Davis, Peter Benotti, et al. "Effects of sustained weight loss on outcomes associated with obesity comorbidities and healthcare resource utilization." PLOS ONE 16, no. 11 (2021): e0258545. http://dx.doi.org/10.1371/journal.pone.0258545.
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Objective Determine the impact of long-term non-surgical weight loss maintenance on clinical relevance for osteoarthritis, cancer, opioid use, and depression/anxiety and healthcare resource utilization. Methods A cohort of adults receiving primary care within Geisinger Health System between 2001–2017 was retrospectively studied. Patients with ≥3 weight measurements in the two-year index period and obesity at baseline (BMI ≥30 kg/m2) were categorized: Obesity Maintainers (reference group) maintained weight within +/-3%; Weight Loss Rebounders lost ≥5% body weight in year one, regaining ≥20% of weight loss in year two; Weight Loss Maintainers lost ≥5% body weight in year one, maintaining ≥80% of weight loss. Association with development of osteoarthritis, cancer, opioid use, and depression/anxiety, was assessed; healthcare resource utilization was quantified. Magnitude of weight loss among maintainers was evaluated for impact on health outcomes. Results In total, 63,567 patients were analyzed including 67% Obesity Maintainers, 19% Weight Loss Rebounders, and 14% Weight Loss Maintainers; median follow-up was 9.7 years. Time until osteoarthritis onset was delayed for Weight Loss Maintainers compared to Obesity Maintainers (Logrank test p <0.0001). Female Weight Loss Maintainers had a 19% and 24% lower risk of developing any cancer (p = 0.0022) or obesity-related cancer (p = 0.0021), respectively. No significant trends were observed for opioid use. Weight loss Rebounders and Maintainers had increased risk (14% and 25%) of future treatment for anxiety/depression (both <0.0001). Weight loss maintenance of >15% weight loss was associated with the greatest decrease in incident osteoarthritis. Healthcare resource utilization was significantly higher for Weight Loss Rebounders and Maintainers compared to Obesity Maintainers. Increased weight loss among Weight Loss Maintainers trended with lower overall healthcare resource utilization, except for hospitalizations. Conclusions In people with obesity, sustained weight loss was associated with greater clinical benefits than regained short-term weight loss and obesity maintenance. Higher weight loss magnitudes were associated with delayed onset of osteoarthritis and led to decreased healthcare utilization.
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Hachfi, H., D. Khalifa, M. Brahem, N. Ben Chekaya, and M. Younes. "POS1281 HOW DOES OBESITY INFLUENCE THE FEATURES OF KNEE OSTEOARTHRITIS?" Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 923.4–924. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3602.
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Background:Knee osteoarthritis and obesity are both major health problems. It is now admitted that the prevalence of knee osteoarthritis gets higher with obesity and that weight loss helps knee function and allows patients to avoid surgery.Objectives:The aim of this study was to study the influence of obesity on knee osteoarthritis features.Methods:A cross-sectional study was conducted in the university hospital Taher Sfar of Tunisia over a period of 6 months. Patients who had knee osteoarthritis confirmed by radiographs were included. Sociodemographic, clinical, radiological and therapeutic data were collected from medical records and visits. Obesity was defined by a body mass index (BMI) ≥30. Functional impairment was assessed by the Womac index and Lequesne index.Results:The study included 186 patients. There were 31 males and 155 femmes. The mean age was 60±10 years. The percentage of obese patients was 53,8%. The mean age was similar in both groups obese and non obese. There were more women in the obese group compared to the non obese group (p=0.0001), more patients who had diabetes mellitus and dyslipidemia (p=0.002). Non-obese patients had a shorter duration of symptoms with no statistical significance (p=0.151). Obese patients had more involvement of both knees (p<0.0001). Obesity did not have an impact on pain severity. Severity of radiological images (p=0,0001) were more frequent in obese patients. Functional impairment was similar in both groups. However, the percentage of patients having a very important functional impairment with Lequesne index was higher in obese patients (p<0.029). Obese patients also needed more physical therapy sessions (p=0.035).Conclusion:Knee osteoarthritis in obese patients is characterized with the femlae gender predominance, bilateral knee involvement, and a more severe images on radiographs. Thus the need for better control of weight and the importance of physical activity.References:[1]Coggon D, Reading I, Croft P, et al. Knee osteoarthritis and obesity. Int J Obes Relat Metab Disord J Int Assoc Study Obes 2001; 25: 622–627.Disclosure of Interests:None declared
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Lapshina, S., L. Feiskhanova, A. Nurmieva, and K. Sadriev. "AB0871 OSTEOARTHRITIS IN OBESE PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1741.1–1742. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3910.
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Background:Obesity is a recognized risk factor for osteoarthritis (OA) of the knee joints, which is associated with increased biomechanical stress. However, the association of OA with metabolic syndrome is more multifaceted, since overweight and obese people have a similar increased risk of OA of the hand joints that do not carry weight, due to systemic factors.Objectives:To identify the features of the course of OA in overweight patients.Methods:52 patients with an established diagnosis of osteoarthritis were examined: women - 84.6%, men - 15.4%, average age - 60.9 ± 8.9 years (32 to 78 years). Clinical examination, calculation of body mass index (BMI), determination of the X-ray stage of OA according to the Kellgren and Lawrence system; ultrasound examination of the knee joints; assessment of the severity of pain according to visual analog scale (VAS); the index WOMAC was used to evaluate pain, stiffness and physical function. We evaluated the quality of life by EQ-5D.Results:The duration of OA was 8.75 [2.58; 26] years. The distribution of patients according to the X-ray stage of OA: I - 9.6%, II - 57.6%, III - 26.9%, IV - 5.9% of patients. The BMI range was from 21 to 43 kg/. A BMI up to 30 kg/ was found in 22 patients: 17.3% - normal weight, 25% - excess body weight. Thirty patients has BMI more than 30 kg/: I degree - 38.4%, II degree - 15.3%, III degree - 4%. Obese patients rated pain according to the VAS scale of 1.3 the score is more intensively than patients with a BMI <30 kg/m2(p <0.001). A detailed examination of each subsequent degree of obesity revealed a tendency to reduce the pain syndrome from 7.52 points at 1 degree of obesity to 5 points at 3 degrees of obesity (p <0.001). With increasing body weight, there was an increase in difficulties in daily activities according to the WOMAC (p <0.05). Reactive knee synovitis was detected in 25 (48%) patients. The incidence of synovitis in patients with a BMI <30 kg / m2is 27%, with a BMI> 30 kg / m2is 68%. Patients with obesity of 1stdegree had synovitis in 65%, 2nddegree - 75%, 3rddegree - 84% of cases (p <0.05). A high correlation between the x-ray stage of OA and BMI (r = 0.74; p <0.001) was revealed. According to the EQ-5D questionnaire, patients with the 1stdegree of obesity (2.31 ± 1.3) were very anxious, but the level of anxiety decreases in patients with 3rddegree of obesity (1.44 ± 0.9) and it’s equal to that in individuals with normal body weight (1.33 ± 0.8).Conclusion:The existence of obesity in patients with OA is associated with an increase in pain, a significant decrease in functional ability, a presence of reactive synovitis of the knee joints, aggravation of the X-ray stage of OA, and the appearance of anxiety and depression. However, with the further progression of obesity, the levels of anxiety for one’s condition decrease.References:[1]Felson DT, Zhang Y, Hannan MT et al. Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham study. Arthritis Rheum. 1997; 40: 728–733.[2]Huffman KM. Osteoarthritis and the metabolic syndrome: more evidence that the etiology of OA is different in men and women. 2012; 20 (7): 603–604.Disclosure of Interests:None declared
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Lobenhoffer, Philipp. "Indication for Unicompartmental Knee Replacement versus Osteotomy around the Knee." Journal of Knee Surgery 30, no. 08 (2017): 769–73. http://dx.doi.org/10.1055/s-0037-1605558.
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AbstractUnicompartmental medial or lateral osteoarthritis of the knee is found in up to 50% of all osteoarthritic patients and may be addressed surgically either by knee osteotomies or unicompartmental replacements. The limits for indicating one procedure or the other are somehow not defined. This article discusses the diagnostic algorithm and the most important decision factors. A long-leg radiograph and formal deformity analysis is mandatory. If constitutional or posttraumatic metaphyseal deformity in the frontal plane is detected and the opposite compartment is intact, an osteotomy should be considered. The result is not depending on age and grade of osteoarthritis. Unicompartmental knee arthroplasty is indicated in substantial osteoarthritis of one compartment (bone-on-bone) with intact ligaments and a functionally intact contralateral compartment. The anatomy of the femur and tibia should be normal with no gross osseous deformity. Age, obesity, or asymptomatic patellofemoral degeneration are not considered exclusion criteria for those surgical procedures.
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Conde, Javier, Morena Scotece, Rodolfo Gómez, Veronica Lopez, Juan Jesus Gómez-Reino, and Oreste Gualillo. "Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease." Arthritis 2011 (August 18, 2011): 1–8. http://dx.doi.org/10.1155/2011/203901.
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Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis elicited by adipokines. We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in the genesis and progression of osteoarthritis in the hope of modifying it to prevent and treat diseases.
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Serdulets, Y. I. "Peculiarities of clinical course of osteoarthritis combined with type 2 diabetes mellitus, obesity and hypertension." Bulletin of the Club of Pancreatologists 42, no. 4 (2018): 42–46. http://dx.doi.org/10.33149/vkp.2018.04.06.
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The aim of paper is to study the clinical indices of articular syndrome in patients with osteoarthritis combined with type 2 diabetes mellitus, obesity and hypertension. It has been found out that the combined course of osteoarthritis, abdominal obesity and type 2 diabetes mellitus is accompanied by the intensified pain syndrome in the joints, a disruption of the motor function as well as the daily activities of patients.
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Wu, Cheng-Yi, Jen-Wei Huang, Chang-Hao Lin, and Wei-Hsing Chih. "Preoperative overweight and obesity do not cause inferior outcomes following open-wedge high tibial osteotomy: A retrospective cohort study of 123 patients." PLOS ONE 18, no. 1 (2023): e0280687. http://dx.doi.org/10.1371/journal.pone.0280687.
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Open-wedge high tibial osteotomy (OWHTO) is effective in treating medial compartment osteoarthritis. The association between body mass index (BMI) and outcomes following OWHTO is being debated. This study compared radiographic and clinical outcomes between patients with preoperative overweight, obesity, and normal BMI following OWHTO for medial compartment osteoarthritis. In total, 123 patients (123 knees) who underwent OWHTO for medial compartment osteoarthritis were enrolled and were divided into normal-BMI (18.5−24.9 kg/m2), overweight (25−29.9 kg/m2), and obese (>30 kg/m2) groups based on body mass index. The numeric rating scale for pain, mechanical tibiofemoral angle (mTFA), tibia tilting angle (TTA), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for function were evaluated preoperatively and at postoperative follow-ups. The improvements of clinical and radiological outcomes in normal-BMI, overweight, and obese groups were not significantly different. The incidence of soft tissue irritation, wound infection, nonunion, and conversion to total knee arthroplasty were not significantly different between groups.The clinical and radiological outcomes in patients with preoperative overweight, obesity, and normal-BMI were not significantly different. Preoperative overweight and obesity thus has no effect on outcomes following OWHTO during the two years follow-up period. These findings cannot be generalized to patients with morbid obesity.