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Dissertations / Theses on the topic 'Osteoarthritis Drugs'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Harry, Diane Sue. "A Markov model for drug response in patients with osteoarthritis /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487257452615308.

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2

Geiger, Brett Charles. "Designing nanocarriers to penetrate cartilage and improve delivery of biologic drugs for osteoarthritis." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/121874.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019<br>"DOCTOR OF PHILOSOPHY IN BIOLOGICAL ENGINEERING With a focus in Polymers and Soft Matter (PPSM)." Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 106-112).<br>Osteoarthritis is a debilitating joint disease that affects over 30 million people and has no disease-modifying therapies. The current standard of care for the disease is merely palliative until joint replacement is necessary. Disease-modifying osteoarthritis drugs have been tested in the clinic, but al

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Honcharuk, L. M. "The role of helicobacter infection in gastroduodenopathy induced by nonsteroidal anti-inflammatory drugs in patients with osteoarthritis." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19610.

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4

Manning, Lauren Brooke. "Experimental Evaluation of Discoid Domain Receptor 2 as an Ideal Target for Development of Disease-Modifying Osteoarthritis Drugs." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17331959.

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Abstract: Osteoarthritis (OA) affects 250 million people worldwide. Currently, no targets for disease-modifying osteoarthritis drugs exist. Matrix metalloproteinase-13 (MMP-13) would make it an ideal target; however, its broad biological effects restrict its application as a target enzyme of inhibitory drugs in the treatment of OA. The expression and activation of discoidin domain receptor 2 (DDR2) is increased in human OA tissues and mouse models of OA and was co-localized with elevated expression of MMP-13 in degenerative articular cartilages. In healthy articular cartilage, DDR2 is kept

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5

Lomas, Amy. "The renal effects of nonsteroidal anti-inflammatory drugs (NSAIDS) in dogs with chronic kidney disease (CKD)." Thesis, Kansas State University, 2013. http://hdl.handle.net/2097/20475.

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Master of Science<br>Department of Clinical Sciences<br>Gregory F. Grauer<br>Prostaglandins play many important roles in the kidney including regulation of renal blood flow, glomerular filtration, renin release, and sodium excretion. Upon activation of the renin angiotensin aldosterone system (RAAS), prostaglandin upregulation becomes critical to offset the vasoconstrictive effects of norephinephrine, angiotensin II, and vasopressin. Nonsteroidal anti-inflammatory drugs (NSAIDs) produce both their beneficial and detrimental effects through inhibition of the cyclooxygenase enzyme and subse

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6

Swenson, Victor, and Mattias Ekberg. "Usage of Non-steroidal anti-inflammatory drugs in a sample of New Zealanders with osteoarthritis : A cross-sectional study." Thesis, Umeå universitet, Avdelningen för fysioterapi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-171613.

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Introduction Oral Non-steroidal anti-inflammatory drugs (NSAID) is an analgesia and is commonly used by people with osteoarthritis (OA). Oral NSAID is currently recommended as the second level of treatment for OA, and could be considered if physical activity, topical NSAID or paracetamol do not supply sufficient pain relief. Aim To investigate how frequently oral NSAID is used in a sample of New Zealanders with OA and also to investigate the exposure to heightened risk of adverse events while using oral NSAID. Method A cross-sectional survey was conducted to collect information about the u

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Honcharuk, I. M. "The role of pathogenic strains helicobacter pylori in gastroduodenopathies induced by non-steroidal anti-inflammatory drugs in patients with osteoarthritis." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18587.

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8

Sobko, D. I. "Blood pressure changes as a result of taking nonsteroidal anti-inflammatory drugs among the patients who suffer from osteoarthritis with concomitant hypertension." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18060.

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9

Allas, Lyess. "Méthylation de H3K27 : régulation et rôle dans le cartilage articulaire Development of a simple osteoarthritis model useful to predict in vitro the anti-hypertrophic action of drugs." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC426.

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L’arthrose est la maladie rhumatologique la plus répandue et une des causes majeures de douleur et de handicap. Au cours de ce travail nous avons étudié le rôle et la régulation de la tri-méthylation de la lysine 27 de l’histone H3 (H3K27me3) dans l’arthrose et la chondrogenèse.Dans une première partie, nous avons montré que l’inhibition de la méthylase EZH2 par l’EPZ-6438 atténue l’inflammation et la libération de métalloprotéases par les chondrocytes traités à l’IL-1β. L’inhibition d’EZH2 réduit également l’hypertrophie des chondrocytes induite par le TGF-β1. L’EZP-6438 attenue aussi la dégr

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10

Pimentel, Thais Spacov Camargo. "Revisão sistemática: tratamento da osteoartrose com uso de antiinflamatórios não esteroidais em cães." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-12062013-115529/.

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INTRODUÇÃO: A terapia farmacológica de escolha para o tratamento de cães com osteoartrose é o uso de antiinflamatórios não esteroidais. Porém, sua eficácia no controle dos sinais clínicos apresentados pelos animais ainda não foi bem estabelecida em três revisões sistemáticas anteriormente publicadas. OBJETIVOS: Avaliar a qualidade metodológica dos ensaios clínicos randomizados controlados sobre o uso dos antiinflamatórios não esteroidais (AINEs) para o tratamento da dor nos cães com osteoartrose; identificar a melhor opção terapêutica; os principais efeitos adversos envolvidos na sua administr

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11

Freddi, Matthew James. "Intra-articular depot forming drug delivery system for osteoarthritis." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12662/.

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Osteoarthritis (OA) is a chronic degenerative disease of the joint. Current treatments for this disease (such as glucocorticoid steroids) aim to reduce pain and increase mobility. Intra-articular injection is used in OA as treatment can be targeted to affected joints only. There is currently a lack of sustained release formulations for intra-articular injection. The aim of this thesis was to produce and characterise an injectable intra-articular drug delivery system capable of providing delivery of the steroid dexamethasone phosphate (DXMP) over 3 months. This would be an injectable hydrogel t

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12

D'ARRIGO, DANIELE. "Osteoarthritis theranostics: extracellular vesicles and drug microfluidic screening platforms as innovative tools." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/375387.

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Nonostante l'incidenza dell'osteoartrosi (OA) del ginocchio, una delle maggiori cause di disabilità a livello mondiale, sia in crescita, la sua diagnosi precoce è ancora impossibile. L'attuale processo diagnostico è basato sull'esame clinico del paziente e sull'imaging dell'articolazione ma questi esami sono di norma prescritti quando l'OA è in uno stadio avanzato. In aggiunta, questo approccio non riesce a rilevare l'attivazione di processi biologici nell'instaurarsi dell'OA, come l'infiammazione. Per questi motivi la ricerca si è recentemente focalizzata sullo studio di biomarcatori che rile

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13

Young, Whitney Terese. "Cartilage stress relaxation induced by intra-tissue transport of cationic nanoparticles : implications for post-traumatic osteoarthritis drug delivery." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104138.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2016.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 65-72).<br>Avidin has previously been proposed as a drug carrier molecule for intra-articular injection of osteoarthritis (OA) therapeutics. Its nanoscale size and net positive charge make it a viable candidate for transport into and through articu

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14

Whitmire, Rachel Elisabeth. "Self-assembling polymeric nanoparticles for enhanced intra-articular anti-inflammatory protein delivery." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/43587.

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The goal of this thesis was to develop a new drug-delivering material to deliver anti-inflammatory protein for treating OA. Our central hypothesis for this work is that a controlled release/presentation system will more effectively deliver anti-inflammatory protein therapies to the OA joint. The primary goal of this work was to synthesize a block copolymer that could self-assemble into injectable, sub-micron-scale particles and would allow an anti-inflammatory protein, IL-1ra, to be tethered to its surface for efficient protein delivery. The block copolymer incorporated an oligo-ethylene mono

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15

Jang, Kee Woong. "Biophysical effects of ultrasound therapy for cartilage regeneration and microbubble mediated shock waves and drug release control for cancer treatment." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1646.

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Articular cartilage is a complex soft tissue covering the end of moving bones in joints which provide pressure load distribution over the joint surface and smooth lubrication with little friction for establishing movement. Articular cartilage has an intrinsically limited capacity for self-repair when injured due to the lack of nerve and blood supply. Considered that injured cartilage is left untreated, it is likely to undergo progressive cartilage degeneration without pain which may lead to posttraumatic osteoarthritis. Therefore functional and physiologic restoration of injured cartilage back

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16

Aydin, Ozlem. "In Situ, In Vitro And In Vivo Evaluation Of Effectiveness Of New Treatment Approaches Involving Controlled Drug Delivery Systems In Cartilage Degenerations." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613470/index.pdf.

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Osteoarthritis (OA) is a degenerative joint disease which has yet no complete treatment with medication. Doxycycline, a well-known antibiotic, has been shown to prevent matrixmetallopreoteinases-MMPs, indicating potency on OA treatment. However, long term systemic use can cause side effects on other tissues. This study aimed to develop controlled drug delivery systems of doxycycline/doxycycline-chondroitin sulfate (D/D-CS) in the form of PCL microspheres for providing a better and new treatment approach via local application. After optimization studies for size, loading efficiency, surface/str

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17

Tomazoni, Shaiane da Silva. "Efeitos da laserterapia de baixa potência, anti-inflamatório não-esteroidal tópico e atividade física no tratamento de osteoartrite induzida por papaína." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-05102015-200655/.

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Introdução: A osteoartrite (OA) é uma doença que comumente afeta os seres humanos, sendo caracterizada como um processo degenerativo que abrange as articulações. A OA afeta a cartilagem articular, osso subcondral, ligamentos, cápsula articular, membrana sinovial e músculos periarticulares. O tratamento para esta desordem se baseia em terapia farmacológica, não farmacológica e cirúrgica, isoladamente ou em combinação, a fim de maximizar os efeitos benéficos e minimizar os efeitos indesejáveis. O presente estudo tem como objetivo avaliar e comparar os efeitos isolados e combinados da terapia far

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18

Reeff, Jonathan. "Development and evaluation in vitro and in vivo of injectable hydrolipidic gels with sustained-release properties for the management of articular pathologies." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209288.

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Future changes in the incidence and prevalence of OA are difficult to predict. As incidence and prevalence rise with increasing age, extending life expectancy will result in greater numbers with OA. Actually, usual therapeutic approaches are really restricted because of important side effects with long-term use. Therefore, there is a need to develop improved formulations which are well tolerated, biocompatible and biodegradable. Ideally, these new treatments should be able to deliver locally sufficient amount of anti-inflammatory or analgesic drugs into the site of arthritic inflammation while

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19

WU, YA-WUN, and 吳雅雯. "The effects of small molecule drugs ( CN7:1h ) on articular chondrocyte and osteoarthritis." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/z8bdv9.

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20

Chen, Ting-Wen, and 陳亭文. "The Marketing Diffusion Progress of Osteoarthritis Drugs in Taiwan Market: Case study of glucosamine sulfate and chondroitin sulfate." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/01102680933653570783.

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碩士<br>國立交通大學<br>企業管理碩士學程<br>97<br>Viartril, a prescription drug brand with the constituents of glucosamine sulfate that was manufactured to cure degenerative osteoarthritis, has surged in sales and in volume since 1995 to 2009 in Taiwan. The purpose of this paper is to discuss osteoarthritis treatment differences between Taiwan and global market, also to discover the marketing successful factors of glucosamine sulfate in Taiwan drug market. This paper use diffusion theory as the analyzing framework and take a similar constituents, condroitin sulfate, as the compared group. The result showed t

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21

Wei, Yeou-Sheng, and 韋有升. "The cost-effectiveness analysis of hyaluronic acid and traditional oral anti-inflammatory drugs to osteoarthritis knee-use Meta-analysis method." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/81227403579659614906.

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碩士<br>高雄醫學大學<br>醫務管理學研究所碩士在職專班<br>97<br>osteoarthritis arthritis is the highest prevalence of arthritis and in human disease and disability of the most common reasons. osteoarthritis arthritis in the United States is second only to ischemic heart disease caused more than 50-year-old male of the reasons for work disability. Intra-articular injection of hyaluronic acid preparations in the treatment of osteoarthritis knee, which a new or controversial treatments. Medical care providers often raise the appropriateness of treatment, effectiveness, and safety be assessed. Similarly, clinicians must

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22

Liu, Chia-Hao, and 劉家豪. "The Risk of Stroke Associated with Nonsteroidal Anti-Inflammatory Drugs among Osteoarthritis Patients with Atrial Fibrillation: A Population-based Retrospective Cohort Study." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/h55bbk.

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碩士<br>國立臺灣大學<br>藥學研究所<br>106<br>Background: A great number of studies implied that the NSAIDs（non-steroidal anti-inflammatory drug）including COX-2 inhibitors（selective inhibitors of cyclooxygenase-2）and traditional NSAIDs are related to higher risk of vascular events such as myocardial infarction, thromboembolism, and stroke. In addition, atrial fibrillation may also increase the opportunity to cause vascular events. Stroke would lay a serious burden on the medical care system. Consequently, establishing the safety profile of NSAIDs is necessary. This study aims to clarify the association betw

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CHIN, WU HSIU, and 吳秀琴. "A Study to Construct an NHI Resource Use Model for Osteoarthritis Patients Receiving Different Drugs -using NSAIDs and specific COX-2 inhibitors as examples." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/63508471609915054088.

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碩士<br>國立中正大學<br>資訊管理學系暨研究所<br>101<br>Osteoarthritis is a disease of high prevalence, high rate of disability, and low mortality rate. The commonly used oral medications for it include non-steroidal anti-inflammatory drugs (NSAIDs) and specific cyclooxygenase 2 (COX-2) inhibitors. Although NSAIDs are commonly used, it damages the gastric mucosa and produces side effects and complications ranging from gastric pain, to gastrorrhagia, gastrointestinal perforation, and even death, creating additional medical issues and costing more in extra treatment expenses. Specific COX-2 inhibitors are safer fo

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24

Arranhado, Cristina Nicolas. "Relatórios de Estágio e Monografia intitulada "Senescência Celular: Mecanismos e Abordagens Terapêuticas"." Master's thesis, 2017. http://hdl.handle.net/10316/83783.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Os presentes Relatórios de Estágio decorridos na Farmácia São José e no Centro Hospitalar Universitário de Coimbra no âmbito da unidade curricular "Estágio" do Mestrado Integrado em Ciências Farmacêuticas da Universidade de Coimbra, têm como objetivo descrever as atividades e conhecimentos adquiridos, fazendo uma análise crítica do meu percurso enquanto estagiária, na forma de uma Análise S.W.O.T. (Strenghts, Weaknesses, Opportunities and Threats). Ao longo do período de estágio, compree

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25

Deus, João Miguel Loureiro Faria Guerreiro de. "Nanotecnologia na dor articular." Master's thesis, 2014. http://hdl.handle.net/10437/5995.

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Orientação : Catarina Pinto Reis<br>A dor articular é o principal sintoma e problema mais amplamente descrito nas pessoas com osteoartrite. Esta patologia envolve a totalidade da articulação com um significativo impacto na qualidade de vida dos doentes, resultando em funções debilitadas e num profundo absentismo. Caracterizada patologicamente pelas altera-ções estruturais e processos inflamatórios, a dor articular permanece como a condição incapacitante mais reportada aos médicos. É, por isso, descrita como uma doença multifactorial influenciada principalmente pela idade e obesidade, ainda que

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26

Bolduc, Marissa. "Concentration synoviale et plasmatique de diclofénac après son utilisation topique et orale chez le cheval." Thèse, 2008. http://hdl.handle.net/1866/7204.

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27

Kaamini, M. D. "PLGA Based Drug Carriers for Treatment of Osteoarthritis." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5616.

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Osteoarthritis (OA) has affected nearly 22-39% of the Indian population and remains one of the most common musculoskeletal disorders that affects articular joints. Post-traumatic osteoarthritis, which develops following trauma to the knee joint, can lead to severe disability and morbidity in otherwise healthy individuals. The current standard of care for osteoarthritis (OA) primarily revolves around symptomatic relief with total knee arthroplasty at the end stage of the disease. Translation of many disease-modifying OA drugs (DMOADs) stagnates due to low bioavailability at the affected site,

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28

Mwangi, Timothy Kariithi. "Intra-articular Clearance of Silk Microparticles and Macromolecules in Healthy and Arthritic Rat Knee Joints." Diss., 2015. http://hdl.handle.net/10161/11305.

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<p>Osteoarthritis (OA) is a degenerative disease of articular joints characterized by progressive deterioration of the cartilage lining, subchondral bone destruction and thickening of the joint capsule. These tissue changes lead to symptomatic joint pain and joint dysfunction, leading to restrictions on daily life activities. Intra-articular injections of corticosteroids or anti-inflammatory compounds are commonly given to relieve symptoms associated with OA; however, rapid clearance of these compounds from the joint space and into draining synovial lymphatics necessitates the use of drug ca

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Dravid, Ameya. "Resolvin D1-loaded Liposomal Nanocarriers for the Treatment of Osteoarthritis." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5909.

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Osteoarthritis (OA) is the most common disorder of the joints and currently affects >300 million patients worldwide. In this disease, the articulating cartilage undergoes progressive damage which leads to severe pain and loss of function. Current treatment for OA does not target the etiology of the disease but instead focuses only on alleviating pain by administration of steroidal analgesics. Steroidal analgesics are not ideal for the long-term treatment of the disease because they generate chronic chondrotoxicity and cartilage thinning. Eventually, as the disease progresses towards severe s

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30

Garner, Solomon T. "Pharmaceutical preformulation- osteoarthritis therapy via two drug delivery applications the mutual prodrug and the transdermal delivery of a well-known nutraceutical, glucosamine /." 2005. http://purl.galileo.usg.edu/uga%5Fetd/garner%5Fsolomon%5Ft%5F200505%5Fphd.

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Shakibaei, M., C. Csaki, S. Nebrich, and A. Mobasheri. "Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis." 2008. http://hdl.handle.net/10454/6181.

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Osteoarthritis is an inflammatory disease of load-bearing synovial joints that is currently treated with drugs that exhibit numerous side effects and are only temporarily effective on pain, the main symptom of the disease. Consequently, there is an acute need for novel, safe and more effective chemotherapeutic agents for the treatment of osteoarthritis and related arthritic diseases. Resveratrol is a phytoalexin stilbene produced naturally by plants including red grapes, peanuts and various berries. Recent research in various cell models has demonstrated that resveratrol is safe and has potent

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