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Dissertations / Theses on the topic 'Osteoclast'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

O'Brien, Elizabeth Ann. "Regulation of osteoclast activity : differential adhesion of osteoclasts to the bone surface." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343930.

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2

Stephens, Sebastien. "Novel Osteoclast Signalling." Thesis, Griffith University, 2010. http://hdl.handle.net/10072/365823.

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When you say osteoporosis, people think of their grandma’s brittle bones, but scientists think of the osteoclast. When you say cancer, people think of death, but before this, many succumb to the osteoclast. The fact is all these things are true yet it is even truer to say that each disease in fact also has more of the other – osteoporosis and death, and cancer and brittle bones. However, the commonality is undeniably the osteoclast. Scratching the surface of the osteoclast reveals that it is the basis of a diversity of bone-related disorders yet the osteoclast itself is, even given the large a

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3

Wilkinson, Debbie Isabelle. "Visualisation of osteoclast membrane domains." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158808.

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Osteoclasts polarise upon activation and form four distinct membrane domains; the basolateral domain, the sealing zone, the functional secretory domain and the ruffled border. The ruffled border is the resorptive organelle of the cell and provides a large surface area for the release of protons and enzymes into the space beneath the osteoclast. Defects in osteoclast formation or function can lead to diseases such as osteopetrosis. Ruffled border formation is a critical event in osteoclast function but the process by which it and other membrane domains form is only partially understood. Vesicul

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4

Zaidi, Mone. "Novel mechanisms of osteoclast regulation." Thesis, University of London, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411434.

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5

Gu, Xiaomei Everett Eric T. "Physiopathology of osteoclast in bone." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1870.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Master of Science in the Curriculum of Oral Biology." Discipline: Oral Biology; Department/School: Dentistry.

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6

Barnes, Calvin Langston Toure. "C-mpl Expression in Osteoclast Progenitors: A Novel Role for Thrombopoietin in Regulating Osteoclast Development." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06262006-123750/.

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A new paradigm has evolved in which multiple regulatory interactions between the skeletal and hematopoietic systems have been identified. Previous studies have demonstrated that megakaryocytes (MK) play a dual role in skeletal homeostasis by stimulating osteoblast proliferation and simultaneously inhibiting osteoclast (OC) development. Here we identify a novel regulatory pathway in which the main MK growth factor, thrombopoietin (TPO), directly regulates osteoclastogenesis. To study the role of TPO in OC development, spleen or bone marrow (BM) cells (2x10[exponent]6 cells/ml) or BM macrophages

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7

Hale, Annette Julie. "The characterisation of the Pagetic osteoclast." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359919.

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8

Lång, Johanna. "CCL11 and Effects on Pre-osteoclast Migration." Thesis, Umeå universitet, Institutionen för odontologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143797.

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ABSTRACT Periodontitis is a chronic inflammatory disease due to dental bacteria, and the disease is highly prevalent worldwide. Both environmental factors and genetic variation are confounding factors. Characteristic for disease development is degradation of gingival tissue and resorption of the alveolar bone due to inflammation. The cells that are capable to resorb bone is named osteoclasts and those are recruited and activated by numerous cytokines. Cytokines are small signal proteins responsible for cell communication and cell recruitment. Cytokines with chemotactic capacity are called che

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9

Combs, Charlotte Emma. "The role of urocortin in osteoclast physiology." Thesis, St George's, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517193.

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10

MacQuarrie, Robyn Melanie. "Arthroplasty-derived wear particles effect osteoclast differentiation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63539.pdf.

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11

Sarma, Ushasri. "Regulation of human osteoclast formation 17Î² estradiol." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312178.

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12

Berger, Christine Elizabeth Marie. "Superoxide anion in osteoclast and osteoblast function." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265210.

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13

Rathod, Hersha. "Osteoclast-extracellular matrix interaction and intracellular signalling." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387474.

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14

Muguruma, Yukari. "The origin and differentiation of the osteoclast /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/5681.

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15

McManus, Stephen. "Regulation of osteoclast activation and autophagy through altered protein kinase pathways in Paget's disease of bone." Thèse, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8960.

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Résumé : La maladie osseuse de Paget (MP) est un désordre squelettique caractérisé par une augmentation focale et désorganisée du remodelage osseux. Les ostéoclastes (OCs) de MP sont plus larges, actifs et nombreux, en plus d’être résistants à l’apoptose. Même si la cause précise de la MP demeure inconnue, des mutations du gène SQSTM1, codant pour la protéine p62, ont été décrites dans une proportion importante de patients avec MP. Parmi ces mutations, la substitution P392L est la plus fréquente, et la surexpression de p62P392L dans les OCs génère un phénotype pagétique partiel. La protéine p6

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16

Tan, Jamie We-Yin. "The investigation of RANKL TNF-like core domain by truncation mutation." University of Western Australia. School of Surgery and Pathology, 2003. http://theses.library.uwa.edu.au/adt-WU2004.0032.

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Osteoclasts are multinucleated cells found exclusively in bone and are derived from the haematopoietic cells of monocytes/macrophage lineage. The cell-to-cell interaction between osteoblastic/stromal cells and osteoclast precursor cells is necessary for osteoclastogenesis. Receptor Activator of NF-κB ligand (RANKL) was identified as a membrane-bound TNF ligand family member that is the ‘master’ cytokine expressed on osteoblastic/stromal cells, which stimulate osteoclastogenesis through cell-to-cell contact with osteoclast precursors. RANKL is considered to be a factor that is necessary and suf

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17

Moreira, Mariana Matheus. "Efeito do alendronato sódico sobre a atividade clástica na periodontite experimental em ratos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/23/23140/tde-18092014-133646/.

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A periodontite é uma doença de natureza multifatorial e infecciosa, que resulta na inflamação e perda dos tecidos de suporte dos dentes. Essa inflamação é causada por bactérias associadas ao biofilme, causando a perda progressiva de inserção. Os bisfosfonatos são fármacos com capacidade de inibir a reabsorção óssea, atuando nas células clásticas. O presente estudo teve como objetivo investigar os efeitos do alendronato, um bisfosfonato nitrogenado com grande potência antireabsortiva, na evolução da doença periodontal induzida em ratos, bem como a possível presença de necrose óssea no processo

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18

Mattsson, Jan P. "The osteoclast H⁺-ATPase isolation and initial characterization /." Göteborg, Sweden : Dept. of Biochemistry and Biophysics, Dept. of Cell Biology, University of Göteborg and Chalmers University of Technology, 1995. http://books.google.com/books?id=_85qAAAAMAAJ.

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19

Davey, Tamara. "Functional characterisation of a novel osteoclast-derived factor." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0219.

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[Truncated abstract] Intracellular communication between osteoclasts and osteoblasts is imperative to maintain bone integrity. A myriad of molecules are responsible for regulating osteoblast and osteoclast activity. In particular, it is well documented that osteoblast-derived factors are crucial in directly controlling osteoclast formation and function. Since bone formation is coupled to bone resorption, it would be expected that osteoclasts also have some role in regulating the growth and function of osteoblast cells. However, despite extensive research upon osteoclast and osteoblast biology,

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20

Moonga, Baljit Singh. "Studies on the intracellular mechanisms of osteoclast control." Thesis, St George's, University of London, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411462.

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21

Morrison, Matthew Sam. "Osteoclast function : role of extracellular pH and ATP." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369218.

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22

Tran, Anh Nhi. "Examining the role of autophagy in osteoclast function." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=238273.

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Osteoclasts are cells that degrade bone, by forming a ruffled border (RB) membrane, contained within an actin-rich attachment site (the sealing zone; SZ). Lysosomal vesicles fuse to the RB, and release their contents into the extracellular space to degrade bone matrix. LC3, a marker of autophagosomes, localises to the RB, implying that either canonical autophagy (i.e. autophagosomes) or non-canonical autophagy (a process where LC3 localises to non-autophagic membrane) is involved in the resorptive function of osteoclasts. To examine this in detail, this study used a model with reduced canonica

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23

Wang, Ee Jen Wilson. "The effects of infection-related factors on bone resorption." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365291.

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24

Phan, Tuan (Tony). "Functional characterisation of an osteoclast-derived osteoblastic factor (ODOF)." University of Western Australia. School of Surgery and Pathology, 2004. http://theses.library.uwa.edu.au/adt-WU2005.0028.

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[Truncated abstract] Bone is a living tissue and is maintained by the coordinate action of osteoblasts and osteoclasts. The intercellular communication between these two cells is the quintessential mechanism in bone remodelling. Unfortunately, the importance of this interaction is often neglected and its significance is only realised when disruption of this “cross-talk” results in debilitating bone diseases. Additionally, the number of known proteins that are involved in this “cross-talk”, especially those that are osteoclast-derived, and act specifically on osteoblasts, is limited. This discr

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25

Jones, Gemma. "Optimisation and characterisation of osteoblast : osteoclast growth in biomaterials." Thesis, Keele University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505664.

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This investigation aims to utilise the cell-cell communications between osteoblasts and osteoclasts to create a functional tissue engineered construct that is closer to physiological remodelling than current single cell tissue engineered constructs. A ratio of osteoblasts:osteoclasts was optimised as well as a culture medium that supports both cell types. Four different materials, each with excellent properties for tissue engineering including biocompatible and biodegradable, were compared for their ability to support co-cultures. These materials are; silk fibroin, from Bombyx mori (water vapo

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26

O'Grádaigh, Donncha. "Osteoclast regulation in the erosive process in rheumatoid arthritis." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615638.

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27

Walsh, Catherine Ann. "The study of tumour stimulated osteoclast activity in vitro." Thesis, University of Liverpool, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317317.

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28

Luchin, Alexander I. "Regulation of Osteoclast differentiation by Microphthalmia-associated transcription factor /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486399451961539.

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29

Martin, Joanne. "In vitro osteoclast resorption of calcium phosphate bone substitutes." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695663.

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Resorption of calcium phosphate (CaP) biomaterials is traditionally assessed using an osteoclast (QC) resorption assay where resorption pits formed on the CaP surface are analysed by microscopy techniques and quantified on the basis of pit number, pit area or pit volume. Pit area measurements (20) have become common practice when assessing CaP biomaterial resorption in vitro. Apart from the time consuming nature of pit area analysis techniques it is not a precise indicator of resorption; variations in pit depth are not taken into consideration and it is unsuitable for use on porous materials w

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30

Zhu, Min. "Regulation of osteoclast maturation and function by resolvin E1." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12701.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Innate and adaptive immunity actively interact with bone and play an important role in bone physiology and pathology. Acute inflammation is a physiologic response that represents the hosts' first line of defens

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31

Cheng, Tak Sum. "Molecular identification and characterization of novel osteoclast V-ATPase subunits." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0068.

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[Truncated abstract] Osteoclasts are multinucleated giant cells responsible for the resorption of the mineralized bone matrix during the process of bone remodelling. During activation towards bone resorption, polarization of the osteoclast results in the formation of a unique plasma membrane, the ruffled border, the actual resorptive organelle of the osteoclast. Through this domain protons are actively pumped into the resorption lacuna creating an acidic microenvironment that favours the dissolution of the mineralized bone matrix. The polarised secretion of protons is carried out by the action

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32

Zhao, Yuming. "Phenotypic analysis of osteoclast lineage in c-fos mutant mice." Thesis, King's College London (University of London), 2003. https://kclpure.kcl.ac.uk/portal/en/theses/phenotypic-analysis-of-osteoclast-lineage-in-cfos-mutant-mice(fafcec7f-6480-4f8c-87b6-3cca60a475fb).html.

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33

James, Ian Edward. "The production and characterization of human osteoclast-reactive monoclonal antibodies." Thesis, University of Bath, 1992. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303100.

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34

McDermott, Emma. "Characterisation of the osteoclast ruffled border using advanced imaging techniques." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=236980.

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The osteoclast ruffled border is a highly convoluted, complex membrane that is necessary for bone resorption. It is thought to form following mass lysosomal fusion with the boneapposing plasma membrane and vesicular trafficking is vital for its formation and function. The aim of this PhD was to better understand the ultrastructure, formation and function of the ruffled border using TEM and advanced imaging techniques. Ruffled border reformation following calcitonin treatment was visualised and the stages of ruffled border formation were described. Ruffled borders in healthy and osteopetrotic o

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35

Tai, Victoria. "The effects of leukotriene B¦4 on osteoclast formation and osteoclastic bone resorption and the role of osteoblastic cells in these processes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ28805.pdf.

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36

McMichael, Brooke Kristin Trinrud. "Tropomyosin 4, myosin IIA, and myosin X enhance osteoclast function through regulation of cellular attachment structures." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1206052974.

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37

Materozzi, Maria. "Molecular biology of Paget’s Disease of Bone: role of p62 and novel genes." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1104964.

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Paget’s disease of bone (PDB) is an age-related metabolic bone disease characterized by focal lesions of increased bone resorption and formation, eventually leading to bone deformities. The cause of PDB and the mechanisms that give rise to focal lesions are yet to be understood, but findings suggest that the disease is driven by aberrant, highly nucleated, osteoclasts (OCs). In recent years evidences of a genetic involvement were found: mutations in UBA domain of SQSTM1, which encodes for p62, have been reported in both familial and sporadic cases of PDB (P392L most commonly). Although, their

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38

Lees, Rita L. "Osteoclast heterogeneity, the importance of cell size and phase of activity." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0016/NQ53821.pdf.

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39

Brunton, Fiona. "Targeting the osteoclast alpha v beta 3 integrin by phage display." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511761.

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40

Al-Hadi, Hadil. "The effect of Hyperbaric Oxygen Therapy on osteoclast and osteoblast function." Thesis, University of Plymouth, 2013. http://hdl.handle.net/10026.1/1614.

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Bone remodelling, the process by which the skeleton adapts to environmental changes, is dependent on the actions of osteoclasts that resorb bone and osteoblasts which make new bone matrix. Aberrant remodelling underpins bone loss in several debilitating skeletal diseases such as osteoporosis, metastatic breast cancer and multiple myeloma. Changes in remodelling activity can also arise as a consequence of therapeutic intervention for instance intravenous bisphosphonate treatment is associated with osteochemonecrosis of the jaw and localised osteoradionecrosis is a common side effect of radiothe

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41

Huber, Dustin Michael. "ANDROGENS SUPPRESS OSTEOCLAST FORMATION INDUCED BY RANK LIGAND AND M-CSF." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin999020063.

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42

Selinger, Christina Imanta. "Identification of RANKL-Regulated Genes Involved in Osteoclast Differentiation and Resorption." Thesis, Griffith University, 2008. http://hdl.handle.net/10072/367396.

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Peripheral blood mononuclear cells (PBMCs) are pluripotent for osteoclast and macrophage cell lineages. The differentiation of macrophages and osteoclasts from a common monocyte precursor is induced following exposure to macrophage-colony stimulating factor (M-CSF), or both M-CSF and receptor activator of nuclear factor B ligand (RANKL) respectively. Differential gene expression resulting from cytokine treatment of PBMCs was examined over time using differential display PCR (DD-PCR) and quantitative real-time PCR (Q-PCR). Q-PCR analysis verified the expression of a new chemokine, FAM19A1, in a

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43

Obaid, Rami Abdulhadi Abdulmajeed. "Investigating the role of optineurin in bone biology and Paget's disease of bone." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23419.

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Paget’s disease of bone (PDB) is a common disease with a strong genetic component. Approaches such as linkage analysis and candidate gene studies have shown that mutations in Sequestosome 1 (SQSTM1) explain up to 40% of familial cases and 10% of sporadic cases, however the majority of PDB patients have no mutations in this gene. Genome-wide association studies (GWAS) have recently identified new susceptibility loci for PDB including variants at CSF1, TNFRSF11A, OPTN, TM7SF4, PML, NUP205 and RIN3 loci. These loci were confirmed to be associated with PDB in various European populations. OPTN enc

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44

Rezende, Eloiza de. "Estudo do efeito de bisfosfonatos nas células clásticas durante a ossificação endocondral do joelho de ratos e em cultura primária: abordagens morfológicas e moleculares." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-29052014-151314/.

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Na ossificação endocondral, osteoclastos (Oc) reabsorvem os remanescentes de cartilagem, e osteoblastos (Ob) depositam matriz óssea. Bisfosfonatos (Bps) inibem a ação dos Oc. Foi avaliado o efeito dos Bps alendronato (Aln) e etidronato (Etn) em joelhos de ratos jovens (in vivo) e na cultura primária de Oc (in vitro). O material in vivo foi analisado por MEV, MET e ML (morfologia e histoquímica para TRAP). RNA foi extraído para análise por RT-PRC e proteínas para análise por WB, que também foram extraídos após o tratamento da cultura com Bps. O tratamento com Etn revelou lâmina epifiseal desorg

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45

Marques, Natasha D'Andrea Mateus. "Estudo da expressão das moléculas reguladoras da remodelação do osso alveolar durante a movimentação ortodôntica com força contínua em ratos tratados com alendronato sódico." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/23/23140/tde-25022016-165617/.

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A movimentação dentária ortodôntica ocorre através de dois processos, nos quais o osso alveolar é reabsorvido nas áreas de pressão, enquanto que novo osso é formado na área de tração. O processo de reabsorção óssea ocorre pela ação de células multinucleadas, os osteoclastos. Os bisfosfonatos constituem um grupo de fármacos com propriedade de inibir a reabsorção óssea, foi utilizado no presente estudo com a finalidade de interferir na remodelação óssea induzida ortodonticamente. Para isso, força contínua de 15 cN foi aplicada aos primeiros molares superiores de ratos machos Wistar de 2 1/2 mese

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46

Hu, Rong. "Regulation of osteoclast differentiation by transcription factors MITF, PU.1 and EOS." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1166644761.

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47

Dossa, Tanya. "Osteoclast-specific inactivation of the Integrin-Linked Kinase (ILK) inhibits bone resorption." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=99336.

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Bone resorption requires the adhesion of osteoclasts to extracellular matrix (ECM) components, a process mediated by the alphavbeta 3 integrin. Following engagement with the ECM, integrin receptors signal via multiple downstream effectors, including the Integrin-Linked Kinase (ILK). In order to characterize the physiological role of ILK in bone resorption, we generated mice with an osteoclast-specific ILK gene ablation. Mice with one inactivated ILK allele (ILK+/-) were mated with TRAP-Cre transgenic mice. Progeny from this cross (TRAP-Cre;ILK+/-) was bred to mice homozygous for a floxed ILK a

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48

Mellis, David. "The study of RANK mutations associated with the diseases of osteoclast dysfunction." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=166647.

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Osteoclasts are the cells that resorb bone to maintain a healthy skeleton. Receptor activator of NFkB (RANK) is a receptor that is critical for the formation, activity and survival of osteoclasts. A number of mutations have been identified within RANK that cause bone diseases with opposite osteoclast phenotypes. The aim of this thesis was to study the downstream consequences of these disease-associated mutations for RANK protein processing and activation of the RANK signalling pathway. Early onset Paget’s disease of bone (ePDB), Familial Expansile Osteolysis (FEO) and Expansile Skeletal Hyperp

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49

Wani, Mohan Ramchandra. "Regulation of osteoclast formation and activation by TRANCE and prostaglandin Eâ†2." Thesis, St George's, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341938.

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50

Althnaian, Thnaian Ali. "Factors that regulate osteoclast formation and bone resorption in regenerating deer antlers." Thesis, Royal Veterinary College (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439832.

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