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1

Plontke, S., A. Koitschev, U. Ernemann, H. Pressler, R. Zimmermann, and L. Plasswilm. "Massive Osteolyse Gorham-Stout des Felsenbeines und des kraniozervikalen Überganges." HNO 50, no. 4 (April 2002): 354–57. http://dx.doi.org/10.1007/s001060100561.

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2

Ittrich, H., C. H. Lund, and R. Skripitz. "Posttraumatische massive Osteolyse des Thorax und der HWS - Das GORHAM-STOUT-Syndrom." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 174, no. 8 (August 2002): 1040–41. http://dx.doi.org/10.1055/s-2002-32926.

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3

Ebert, R., S. Bau, W. Kenn, J. Zustin, M. Rudert, F. Jakob, and L. Seefried. "Die Gorham-Stout-Erkrankung." Osteologie 18, no. 04 (2009): 276–84. http://dx.doi.org/10.1055/s-0037-1619904.

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ZusammenfassungDie Gorham-Stout-Erkrankung (Gorham-Stout-Disease / GSD) ist charakterisiert durch eine spontane, massive, in der Regel monozentrische Osteolyse, häufig koinzident mit einer lokalen Proliferation kleiner Blut- und/oder Lymphgefäße. Als eigenständige Entität wurde das Krankheitsbild erstmals 1954 beschrieben. Die Erkrankung ist mit etwa 200 in der Literatur beschriebenen Fällen sehr selten und ihre Pathogenese ist bis heute weitestgehend unklar. Diskutiert wird eine Hämangio-/Lymphangiomatose mit konsekutiver Zerstörung des Knochens sowie eine osteoklastäre Überstimulation mit reaktiver, meist von vaskulären Strukturen durchsetzter fibröser Proliferation. Ausgangspunkt können grundsätzlich alle Skelettbereiche sein mit progredientem, auch gelenkübergreifendem Befall benachbarter Knochenund Weichteilstrukturen. Prädilektionsstellen sind der Schultergürtel, das Becken sowie der Kieferbereich. Die Symptome treten oft erst spät auf und sind eher unspezifisch mit uncharakteristischen Schmerzen, Schwellungen oder pathologischen Frakturen. Die Diagnose wird anhand der klinischen, laborchemischen, radiologischen und histopathologischen Befunde nach Ausschluss anderer Ursachen einer lokalen Osteolyse gestellt. Ein etabliertes Therapieverfahren existiert nicht. Wiederholt angewandte Maßnahmen sind die Strahlentherapie und die Gabe von Interferon α-2b zur Unterbindung der vaskulären Proliferationen, Bisphosphonate und Vitamin D zur Stabilisierung des Knochens sowie chirurgische Verfahren zur Entfernung der Läsionen und funktionellen Rekonstruktion. Die prognostische Bandbreite reicht von spontanem Sistieren der Erkrankung bis hin zu komplikativen Verläufen mit hoher Letalität.
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4

Garbers, Eike, Falk Reuther, and Gunther Delling. "Report of a Rare Case of Gorham-Stout Disease of Both Shoulders: Bisphosphonate Treatment and Shoulder Replacement." Case Reports in Rheumatology 2011 (2011): 1–4. http://dx.doi.org/10.1155/2011/565142.

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Massive osteolysis known as Gorham-Stout disease is a rare idiopathic disorder typically affecting long bones in a unifocal pattern. Angiomatosis is strongly connected to the osteolysis. Weather angiomatosis is the cause or the result of osteolysis is subject of intense discussion (Kawasaki et al. (2003), Möller et al. (1999), Radhakrishnan and Rockson (2008)). There are about 200 cases described since 1955. Our patient is a 77-year-old female patient with osteolyses of both shoulders involving the proximal humerus, lateral clavicle, and the glenoid. Under bisphosphonate therapy, the progressive osteolysis stopped on the right side and showed progression on the left. With the patient complaining about severe rest pain and impaired function, we performed surgical reconstruction by implantation of total shoulder prosthesis three months after onset of symptoms. Our case shows a possibility of primary and early surgical reconstruction with good clinical outcome.
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5

Shives, Thomas C., John W. Beabout, and K. Krishnan Unni. "Massive Osteolysis." Clinical Orthopaedics and Related Research 294 (September 1993): 267–76. http://dx.doi.org/10.1097/00003086-199309000-00038.

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6

Moore, Mark H., L. K. Lam, and C. M. Ho. "Massive Craniofacial Osteolysis." Journal of Craniofacial Surgery 6, no. 4 (July 1995): 332–36. http://dx.doi.org/10.1097/00001665-199507000-00013.

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7

Sato, K., S. Yamamura, H. Sugiura, T. Mieno, T. Nagasaka, and N. Nakashima. "Gorham massive osteolysis." Archives of Orthopaedic and Trauma Surgery 116, no. 8 (October 1997): 510–13. http://dx.doi.org/10.1007/bf00387590.

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8

Sato, K., H. Sugiura, S. Yamamura, T. Mieno, T. Nagasaka, and N. Nakashima. "Gorham massive osteolysis." Archives of Orthopaedic and Trauma Surgery 116, no. 8 (October 1, 1997): 510–13. http://dx.doi.org/10.1007/s004020050175.

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9

MATSUMOTO, KEISUKE. "A caseof Massive Osteolysis." Nihon Naika Gakkai Zasshi 88, no. 7 (1999): 1332–33. http://dx.doi.org/10.2169/naika.88.1332.

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10

Otteva, E. N., T. Yu Kocherova, E. V. Shepichev, E. N. Otteva, T. Yu Kocherova, and E. V. Shepichev. "Massive osteolysis - gorham-stout syndrome." Osteoporosis and Bone Diseases 14, no. 1 (April 15, 2011): 27–32. http://dx.doi.org/10.14341/osteo2011127-32.

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The paper provides a detailed description of the two cases of one of the rarest diseases - Gorham-Stout syndrome. This syndrome is accompanied by the massive osteolysis of various sites of a bone tissue. The literary review is done. The isolated osteolysis of the separate bone parts is a non-malignant process, and it goes without abnormalities of its functions. The combination of osteolysis with chylothorax is an unfavorable process. The treatment of this disease is possible only by calcitonin or bisphosphonates.
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11

Deng, Runzhi, Enyi Tang, and Minxing Lu. "Massive Osteolysis of the Mandible." Journal of Craniofacial Surgery 22, no. 6 (November 2011): 2386–88. http://dx.doi.org/10.1097/scs.0b013e318231fdde.

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12

Takeda, Yasunori, Masafumi Kuroda, Atsumi Suzuki, Yukio Fujioka, and Kazuo Takayama. "MASSIVE OSTEOLYSIS OF THE MANDIBLE." Pathology International 37, no. 4 (April 1987): 677–84. http://dx.doi.org/10.1111/j.1440-1827.1987.tb00402.x.

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13

Patel, D. V. "Gorham's Disease or Massive Osteolysis." Clinical Medicine & Research 3, no. 2 (May 1, 2005): 65–74. http://dx.doi.org/10.3121/cmr.3.2.65.

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14

Jangid, Subhash, Ravi Mittal, Vijay Sharma, and Anup Kumar Das. "Progressive massive osteolysis of the humerus." Journal of Shoulder and Elbow Surgery 15, no. 3 (May 2006): 386–90. http://dx.doi.org/10.1016/j.jse.2005.03.005.

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15

Rao, S. V., D. R. Reddy, G. M. Reddy, P. K. Reddy, U. L. Mohan, and M. Reddy. "Idiopathic massive osteolysis of skull bones." Neurosurgery 21, no. 4 (October 1987): 564???6. http://dx.doi.org/10.1097/00006123-198710000-00023.

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16

Foult, Hervé, Philippe Goupille, Bruno Aesch, Jean-Pierre Valat, Philippe Burdin, and Michel Jan. "Massive Osteolysis of the Cervical Spine." Spine 20, no. 14 (July 1995): 1636–39. http://dx.doi.org/10.1097/00007632-199507150-00014.

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17

Renacci, Ryan M., and Roger J. Bartolotta. "Gorham disease: lymphangiomatosis with massive osteolysis." Clinical Imaging 41 (January 2017): 83–85. http://dx.doi.org/10.1016/j.clinimag.2016.10.007.

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18

Ohya, Takanori, Sadahiko Shibata, and Yasunori Takeda. "Massive osteolysis of the maxillofacial bones." Oral Surgery, Oral Medicine, Oral Pathology 70, no. 6 (December 1990): 698–703. http://dx.doi.org/10.1016/0030-4220(90)90003-b.

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19

Frankel, D. G., Jonathan S. Lewin, and Bruce Cohen. "Massive osteolysis of the skull base." Pediatric Radiology 27, no. 3 (March 19, 1997): 265–67. http://dx.doi.org/10.1007/s002470050120.

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20

Khosrovi, Houman, Orlando Ortiz, Howard H. Kaufman, Sydney S. Schochet, Gurijala N. Reddy, and Donn Simmons. "Massive osteolysis of the skull and upper cervical spine." Journal of Neurosurgery 87, no. 5 (November 1997): 773–80. http://dx.doi.org/10.3171/jns.1997.87.5.0773.

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✓ Massive osteolysis is a type of idiopathic osteolysis in which there is spontaneous onset of bone resorption. Almost any bone in the body can be affected. The authors present the case of a 62-year-old man diagnosed with massive osteolysis of the occipital bone and the upper two cervical vertebrae. Despite extensive pneumocephalus, no neurological sign or spinal instability was evident. In this case 4000 cGy of radiation in 200-cGy fractions was administered to the diseased area while the patient was kept in a Miami-J collar. At the 2-year follow-up examination, arrest of the disease process and new bone formation was evident on radiographic studies.
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21

Fukushima, Tatsuya, Kenji Kumagai, Masahiko Suzuki, Hiroyuki Shindo, and Masahumi Kohno. "Two Cases of Suspected Massive Osteolysis, Radiographically." Orthopedics & Traumatology 50, no. 3 (2001): 809–13. http://dx.doi.org/10.5035/nishiseisai.50.809.

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22

Stavlas, Panagiotis, Vassiliki Katsiva, and Yiannis Kouvaras. "Massive Osteolysis of the Hip: Gorham’s Disease." Orthopedics 30, no. 12 (December 1, 2007): 1059–60. http://dx.doi.org/10.3928/01477447-20071201-09.

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23

Migliorati, Cesar A. "Commentary: massive osteolysis or Gorham-Stout disease." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 109, no. 2 (February 2010): 242–43. http://dx.doi.org/10.1016/j.tripleo.2009.09.030.

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24

Wohar, Robert M. "A call for information on massive osteolysis." Journal of Oral and Maxillofacial Surgery 46, no. 3 (March 1988): 176. http://dx.doi.org/10.1016/0278-2391(88)90078-x.

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25

Duke, Phillip F. R., W. Angus Wallace, and Simon P. Frostick. "Gorham's massive osteolysis, management with an endoprosthesis." Journal of Shoulder and Elbow Surgery 5, no. 2 (March 1996): S69. http://dx.doi.org/10.1016/s1058-2746(96)80321-1.

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26

Mendez, Armando A., David Keret, William Robertson, and G. Dean MacEwen. "Massive Osteolysis of the Femur (Gorhamʼs Disease)." Journal of Pediatric Orthopaedics 9, no. 5 (September 1989): 604–8. http://dx.doi.org/10.1097/01241398-198909010-00019.

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27

Fujiu, Koichi, Ryuzo Kanno, Hiroyuki Suzuki, Naoya Nakamura, and Mitsukazu Gotoh. "Chyothorax associated with massive osteolysis (Gorham’s syndrome)." Annals of Thoracic Surgery 73, no. 6 (June 2002): 1956–57. http://dx.doi.org/10.1016/s0003-4975(02)03413-6.

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28

Bianchi, L., G. Bernardi, A. Orlandi, and S. Chimenti. "Basosquamous cell carcinoma with massive cranial osteolysis." Clinical and Experimental Dermatology 28, no. 1 (January 2003): 96–97. http://dx.doi.org/10.1046/j.1365-2230.2003.01156_4.x.

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29

Riantawan, P., S. Tansupasawasdikul, and P. Subhannachart. "Bilateral chylothorax complicating massive osteolysis (Gorham's syndrome)." Thorax 51, no. 12 (December 1, 1996): 1277–78. http://dx.doi.org/10.1136/thx.51.12.1277.

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30

Cannon. "Massive osteolysis. A review of seven cases." Journal of Bone and Joint Surgery. British volume 68-B, no. 1 (January 1986): 24–28. http://dx.doi.org/10.1302/0301-620x.68b1.3941137.

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31

Möller, G., M. Priemel, M. Amling, M. Werner, A. S. Kuhlmey, and G. Delling. "The Gorham-Stout syndrome (Gorham’s massive osteolysis)." Journal of Bone and Joint Surgery. British volume 81-B, no. 3 (May 1999): 501–6. http://dx.doi.org/10.1302/0301-620x.81b3.0810501.

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32

Manepalli, A. N., K. R. Smith, J. E. Sherrill, and M. Sundaram. "MASSIVE OSTEOLYSIS (GORHAMʼS DISEASE) OF THE SKULL." Journal of Neuropathology and Experimental Neurology 58, no. 5 (May 1999): 563. http://dx.doi.org/10.1097/00005072-199905000-00226.

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33

Fisher, Keith L., and M. Anthony Pogrel. "Gorham's syndrome (massive osteolysis): A case report." Journal of Oral and Maxillofacial Surgery 48, no. 11 (November 1990): 1222–25. http://dx.doi.org/10.1016/0278-2391(90)90543-b.

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34

Pazzaglia, U. E., R. Mora, and L. Ceciliani. "Lymphangiomatosis of the arm with massive osteolysis." International Orthopaedics 11, no. 4 (December 1987): 367–69. http://dx.doi.org/10.1007/bf00271316.

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35

Lata, Jeevan, Rakesh Sharma, and Monika Parmar. "Massive osteolysis of hemimandible: a case report." Journal of Maxillofacial and Oral Surgery 8, no. 4 (December 2009): 381–83. http://dx.doi.org/10.1007/s12663-009-0092-x.

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36

Pozdeev, A. P., E. A. Zakhar’yan, D. S. Buklaev, I. N. Krasnogorskiy, and T. F. Zubairov. "Idiopathic Multifocal Osteolysis: Case of Surgical Treatment." N.N. Priorov Journal of Traumatology and Orthopedics 22, no. 3 (September 15, 2015): 78–83. http://dx.doi.org/10.17816/vto201522378-83.

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Idiopathic osteolysis is a rare disorder characterized by spontaneous, massive and progressive resorption of bone tissue. Massive osteolysis results from proliferation of blood and lymphatic vessels with thin walls, resembling capillaries, in the bone and surrounding soft tissues. Literature review on this problem and clinical case of a patient successfully operated on using the technique elaborated at our clinic are presented. Surgical interventions enabled to achieve the restoration of tubular bones integrity and ensured conditions for independent patient’s movement. Possibility of the performance of reconstructive surgical interventions for the restoration of limb weight bearing ability that is reasonable to combine with bisphosphonate therapy.
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37

Pozdeev, A. P., E. A. Zakhar’Yan, D. S. Buklaev, I. N. Krasnogorskiy, and T. F. Zubairov. "Idiopathic Multifocal Osteolysis: Case of Surgical Treatment." Vestnik travmatologii i ortopedii imeni N.N. Priorova, no. 3 (September 30, 2015): 78–83. http://dx.doi.org/10.32414/0869-8678-2015-3-78-83.

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Idiopathic osteolysis is a rare disorder characterized by spontaneous, massive and progressive resorption of bone tissue. Massive osteolysis results from proliferation of blood and lymphatic vessels with thin walls, resembling capillaries, in the bone and surrounding soft tissues. Literature review on this problem and clinical case of a patient successfully operated on using the technique elaborated at our clinic are presented. Surgical interventions enabled to achieve the restoration of tubular bones integrity and ensured conditions for independent patient’s movement. Possibility of the performance of reconstructive surgical interventions for the restoration of limb weight bearing ability that is reasonable to combine with bisphosphonate therapy.
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38

Hugo, B., and M. Schmidt. "Pseudotumor der Schulter bei Zustand nach massiver Osteolyse (Gorham-Stout)." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 150, no. 01 (January 1989): 108–10. http://dx.doi.org/10.1055/s-2008-1046988.

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39

SHIBATA, Sadahiko, Takanori OHYA, Yukio FUJIOKA, and Yasunori TAKEDA. "A case of Massive osteolysis affecting the mandible." Japanese Journal of Oral & Maxillofacial Surgery 33, no. 4 (1987): 718–22. http://dx.doi.org/10.5794/jjoms.33.718.

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40

Ohnishi, Tetsuo, Yasuyuki Kano, Mitsuhiro Nakazawa, and Masayoshi Sakuda. "Massive osteolysis of the mandible: A case report." Journal of Oral and Maxillofacial Surgery 51, no. 8 (August 1993): 932–34. http://dx.doi.org/10.1016/s0278-2391(10)80119-3.

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41

Dan'ura, Tomoyuki, Toshifumi Ozaki, Shinsuke Sugihara, Kohji Taguchi, and Hajime Inoue. "Massive osteolysis in the pelvis—a case report." Acta Orthopaedica Scandinavica 69, no. 2 (January 1998): 197–98. http://dx.doi.org/10.3109/17453679809117629.

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42

Pans, Steven, Jean-Pierre Simon, and Carl Dierickx. "Massive osteolysis of the shoulder (Gorham-Stout syndrome)." Journal of Shoulder and Elbow Surgery 8, no. 3 (May 1999): 281–83. http://dx.doi.org/10.1016/s1058-2746(99)90144-1.

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43

Motamedi, Mohammad Hosein Kalantar, Seyyed Mohammad Homauni, and Hossein Behnia. "Massive osteolysis of the mandible: a case report." Journal of Oral and Maxillofacial Surgery 61, no. 8 (August 2003): 957–63. http://dx.doi.org/10.1016/s0278-2391(03)00235-0.

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44

KANEMURA, Hironari, Junichi SATO, Hiroaki ISHII, Hideki SEKIYA, Yutaka FUKUSHIMA, and Kanichi SETO. "A case of massive osteolysis involving the maxilla." Japanese Journal of Oral & Maxillofacial Surgery 47, no. 3 (2001): 200–202. http://dx.doi.org/10.5794/jjoms.47.200.

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45

Assoun, Jacques, Gérard Richardi, Jean Jacques Railhac, Pascal Le Guennec, Michel Caulier, Carole Dromer, Laurent Sixou, Bernard Fournie, Michel Mansat, and D. Durroux. "CT and MRI of Massive Osteolysis of Gorham." Journal of Computer Assisted Tomography 18, no. 6 (November 1994): 981–84. http://dx.doi.org/10.1097/00004728-199411000-00027.

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46

Roy, Niloy, Nasir Shah, and J. F. Haines. "Massive osteolysis of tibia following metastatic breast carcinoma." European Journal of Orthopaedic Surgery & Traumatology 13, no. 4 (December 1, 2003): 251–52. http://dx.doi.org/10.1007/s00590-003-0099-9.

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47

He, Xiaodong, Yan Jiang, Weibo Xia, Feng Gu, Ou Wang, Mei Li, Xunwu Meng, Xiaoping Xing, and Wei Yu. "Gorham's disease — One case with extensive massive osteolysis." Bone 43 (October 2008): S108—S109. http://dx.doi.org/10.1016/j.bone.2008.07.229.

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48

Rao, Ranga S. V., Raja D. Reddy, Madhav G. Reddy, Kantha P. Reddy, U. L. Mohan, and Mohan Reddy. "Idiopathic Massive Osteolysis of Skull Bones: A Case Report." Neurosurgery 21, no. 4 (October 1, 1987): 564–66. http://dx.doi.org/10.1227/00006123-198710000-00023.

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Abstract A rare case of idiopathic massive osteolysis involving cranial bone is reported. Radiological and computed tomographic findings are discussed, along with a brief review of the literature. (Neurosurgery 21:564-566, 1987)
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49

Lindsay, S., V. Johnson, G. Child, and M. Farrell. "Massive osteolysis in a dog resembling Gorham’s disease in humans." Veterinary and Comparative Orthopaedics and Traumatology 24, no. 05 (2011): 389–97. http://dx.doi.org/10.3415/vcot-11-03-0047.

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SummaryAn eight-month-old mixed-breed dog was presented with a history of sudden onset pelvic limb lameness. Radiographic and computed tomographic examinations demonstrated an osteolytic process involving the lumbar spine and pelvis. A comprehensive work-up including serial radiographic skeletal survey, biopsy, routine laboratory investigation and evaluation of parathyroid hormone (PTH) and 25-hydroxy-vitamin D levels failed to reveal any underlying cause for the osteolysis. Conservative treatment using the bisphosphonate drug alendronate and oral analgesic medications resulted in a return to nearly normal long-term function, despite massive lumbar and pelvic osteolysis. The clinical, radiological and histopathological features in this dog are reported, and similarities with the human condition known as Gorham’s disease are discussed.
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50

Mohapatra, Mounabati, Ashok Kumar Jena, Arun Kumar Dandapat, and Sombir Singh. "Vanishing Mandible in a 7-year Old Child: Response to Radiation Therapy." Journal of Clinical Pediatric Dentistry 41, no. 6 (January 1, 2017): 472–77. http://dx.doi.org/10.17796/1053-4628-41.6.10.

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Massive osteolysis in a 7-year old child is a rare condition. The etiology of massive osteolysis is unknown and it results in the progressive destruction of bony structures. There is no standard therapy available in the literature. Conservative treatment is often used for its management. Radiotherapy is considered as an accepted form of treatment with greater chance of success when it is used in the early course of disease. There are few case reports in the literature in which radiotherapy has been used for the treatment. This article highlights the literature update on various treatment modalities and a case managed by radiation therapy.
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