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Journal articles on the topic 'Osteopontin. Blood-vessels'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Iwanaga, Y., M. Ueno, M. Ueki, et al. "The expression of osteopontin is increased in vessels with blood–brain barrier impairment." Neuropathology and Applied Neurobiology 34, no. 2 (2008): 145–54. http://dx.doi.org/10.1111/j.1365-2990.2007.00877.x.

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2

Li, Tianjia, Leng Ni, Xinnong Liu, Zhanqi Wang, and Changwei Liu. "High glucose induces the expression of osteopontin in blood vessels in vitro and in vivo." Biochemical and Biophysical Research Communications 480, no. 2 (2016): 201–7. http://dx.doi.org/10.1016/j.bbrc.2016.10.027.

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3

Rittling, S. R., P. L. Wejse, K. Yagiz, G. A. Warot, and T. Hui. "Suppression of tumour growth by orally administered osteopontin is accompanied by alterations in tumour blood vessels." British Journal of Cancer 110, no. 5 (2014): 1269–77. http://dx.doi.org/10.1038/bjc.2014.10.

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4

Shah, Sumedh, Garima Yagnik, Alan Nguyen, et al. "TMIC-57. PRO-TUMORAL EFFECTS OF INTRA-TUMORAL NEUTROPHILS IN THE GLIOBLASTOMA MICROENVIRONMENT." Neuro-Oncology 21, Supplement_6 (2019): vi260. http://dx.doi.org/10.1093/neuonc/noz175.1091.

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Abstract While macrophage enrichment and lymphocyte depletion have been described in glioblastoma, intratumoral neutrophils and their effect on glioblastoma have been under-characterized. While tumor-associated neutrophils (TANs) were initially regarded as passive bystanders due to their short-lived nature, investigation of TANs in other cancer types revealed pro-tumoral roles. Therefore, we sought to characterize TANs in the glioblastoma microenvironment using transcriptomic analysis and define their oncologic effects. Flow cytometric analysis of patient samples for neutrophils (CD11b+/CD15+/

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5

Wing, Theodore T., David W. Erikson, Robert C. Burghardt, Fuller W. Bazer, Kayla J. Bayless, and Greg A. Johnson. "OPN binds alpha V integrin to promote endothelial progenitor cell incorporation into vasculature." Reproduction 159, no. 4 (2020): 465–78. http://dx.doi.org/10.1530/rep-19-0358.

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Angiogenesis is fundamental to the expansion of the placental vasculature during pregnancy. Integrins are associated with vascular formation; and osteopontin is a candidate ligand for integrins to promote angiogenesis. Endothelial progenitor cells (EPCs) are released from bone marrow into the blood and incorporate into newly vascularized tissue where they differentiate into mature endothelium. Results of studies in women suggest that EPCs may play an important role in maintaining placental vascular integrity during pregnancy, although little is known about how EPCs are recruited to these tissu

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6

Castello, Luigi Mario, Davide Raineri, Livia Salmi, et al. "Osteopontin at the Crossroads of Inflammation and Tumor Progression." Mediators of Inflammation 2017 (2017): 1–22. http://dx.doi.org/10.1155/2017/4049098.

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Complex interactions between tumor and host cells regulate systemic tumor dissemination, a process that begins early at the primary tumor site and goes on until tumor cells detach themselves from the tumor mass and start migrating into the blood or lymphatic vessels. Metastatic cells colonize the target organs and are capable of surviving and growing at distant sites. In this context, osteopontin (OPN) appears to be a key determinant of the crosstalk between cancer cells and the host microenvironment, which in turn modulates immune evasion. OPN is overexpressed in several human carcinomas and

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Kosmopoulos, Marinos, Stavroula A. Paschou, Julia Grapsa, et al. "The Emerging Role of Bone Markers in Diagnosis and Risk Stratification of Patients With Coronary Artery Disease." Angiology 70, no. 8 (2019): 690–700. http://dx.doi.org/10.1177/0003319718822625.

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Molecules that govern bone metabolism, such as osteoprotegerin (OPG) and osteopontin (OPN), have been isolated from other tissues, including blood vessels. Atherosclerosis and coronary artery disease (CAD) are leading causes of mortality worldwide. Despite novel biochemical and imaging techniques, early detection of CAD is still unsatisfactory. Experimental data indicate that bone turnover markers (BTMs) contribute to the development of atherosclerosis. This finding has sparked interest in their clinical use. This narrative review analyzed information from >50 human studies, which strongly

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Dumanskiy, Yu V., O. Yu Stoliarova, O. V. Syniachenko, and E. D. Iegudina. "ENDOTHELIAL DYSFUNCTION OF VESSELS AT LUNG CANCER." Experimental Oncology 37, no. 4 (2015): 277–80. http://dx.doi.org/10.31768/2312-8852.2015.37(4):277-280.

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Aim: To evaluate changes in indicators of endothelial function and their relationship with morphological forms of disease, stage of pathological process and tumor markers, by analysis the peripheral blood of lung cancer (LC) patients. Materials and Methods: 38 LC patients without metastases (mean age — 57 years) prior chemo- and radiotherapy were included in the study. The duration of the disease manifestation was 18 months. 21% of patients had small cell LC, and the rest — non-small cell LC. The ratio of patients with stages IA, IB, IIA, IIB, IIIA and IIIB LC was 1 : 3 : 3 : 4 : 4 : 4. The en

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9

Aztatzi-Aguilar, Octavio Gamaliel, Martha Patricia Sierra-Vargas, Manolo Ortega-Romero, and Azucena Eunice Jiménez-Corona. "Osteopontin’s relationship with malnutrition and oxidative stress in adolescents. A pilot study." PLOS ONE 16, no. 3 (2021): e0249057. http://dx.doi.org/10.1371/journal.pone.0249057.

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Osteopontin (OPN) is a protein involved in inflammatory illnesses such as fibrosis and cancer; its overexpression in cardiovascular diseases promotes the biomineralization of blood vessels and other soft tissues. Moreover, there is an active component of oxidative stress related with those diseases. The present study relates serum OPN levels with nutritional condition and oxidative stress in a group of adolescents. Anthropometric measurements were performed, and fasting blood samples were analyzed to determine OPN concentrations, blood chemistry parameters (glucose, triglycerides, total choles

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10

Anbarasen, Lalita, Jasmine Lim, Retnagowri Rajandram, Kein Seong Mun, and Sheau Fung Sia. "Expression of osteopontin, matrix metalloproteinase-2 and -9 proteins in vascular instability in brain arteriovenous malformation." PeerJ 7 (June 24, 2019): e7058. http://dx.doi.org/10.7717/peerj.7058.

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Background Matrix metalloproteinase (MMP)-2 and -9 are Osteopontin (OPN) dependent molecules implicated in the destabilization of blood vessels. OPN and MMPs have been studied in brain arteriovenous malformation (BAVM) patients’ tissues and blood samples before intervention. In this study, we compared the serum level of these markers before and after treatment, as well as assessed their protein expressions in BAVM tissues to evaluate their roles in this disease. Methodology Serum samples from six BAVM patients and three control subjects were analyzed using enzyme-linked immunoabsorbent assay (

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11

Reich, A., N. Jaffe, A. Tong, et al. "Weight loading young chicks inhibits bone elongation and promotes growth plate ossification and vascularization." Journal of Applied Physiology 98, no. 6 (2005): 2381–89. http://dx.doi.org/10.1152/japplphysiol.01073.2004.

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The mechanical stimuli resulting from weight loading play an important role in mature bone remodeling. However, the effect of weight loading on the developmental process in young bones is less well understood. In this work, chicks were loaded with bags weighing 10% of their body weight during their rapid growth phase. The increased load reduced the length and diameter of the long bones. The average width of the bag-loaded group's growth plates was 75 ± 4% that of the controls, and the plates showed increased mineralization. Northern blot analysis, in situ hybridization, and longitudinal cell c

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12

Huang, Qiong, and Nader Sheibani. "High glucose promotes retinal endothelial cell migration through activation of Src, PI3K/Akt1/eNOS, and ERKs." American Journal of Physiology-Cell Physiology 295, no. 6 (2008): C1647—C1657. http://dx.doi.org/10.1152/ajpcell.00322.2008.

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Hyperglycemia impacts retinal vascular function and promotes the development and progression of diabetic retinopathy, which ultimately results in growth of new blood vessels and loss of vision. How high glucose affects retinal endothelial cell (EC) properties requires further investigation. Here we determined the impact of high glucose on mouse retinal EC function in vitro. High glucose significantly enhanced the migration of retinal EC without impacting their proliferation, apoptosis, adhesion, and capillary morphogenesis. The enhanced migration of retinal EC under high glucose was reversed i

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13

Hira, Vashendriya V. V., Jill R. Wormer, Hala Kakar, et al. "Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins." Journal of Histochemistry & Cytochemistry 66, no. 3 (2018): 155–73. http://dx.doi.org/10.1369/0022155417749174.

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In glioblastoma, a fraction of malignant cells consists of therapy-resistant glioblastoma stem cells (GSCs) residing in protective niches that recapitulate hematopoietic stem cell (HSC) niches in bone marrow. We have previously shown that HSC niche proteins stromal cell–derived factor-1α (SDF-1α), C-X-C chemokine receptor type 4 (CXCR4), osteopontin (OPN), and cathepsin K (CatK) are expressed in hypoxic GSC niches around arterioles in five human glioblastoma samples. In HSC niches, HSCs are retained by binding of SDF-1α and OPN to their receptors CXCR4 and CD44, respectively. Protease CatK cle

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14

Cohen, Shiri Gur, Tomer Itkin, Orit Kollet, et al. "Regulation Of Hematopoietic Stem Cell Trafficking By The Coagulation Pathway." Blood 122, no. 21 (2013): 456. http://dx.doi.org/10.1182/blood.v122.21.456.456.

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Hematopoeitic stem and progenitor cells (HSPC) dynamically switch between a quiescent, non-motile mode in the bone marrow (BM), to an active state, in which they proliferate, differentiate and egress to the circulation. Injection of the coagulation protease thrombin induced rapid HSPC mobilization to the blood via activation of its major receptor, protease activated receptor 1 (PAR1) on BM hematopoietic and stromal cells. We hypothesized that coagulation factors control stem cells fate in the BM. We examined if thrombin is generated in the murine BM and found by immunohistochemistry prothrombi

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15

Zhang, Lin, Yanyan Zhang, Ying Wu, et al. "Role of the Balance of Akt and MAPK Pathways in the Exercise-Regulated Phenotype Switching in Spontaneously Hypertensive Rats." International Journal of Molecular Sciences 20, no. 22 (2019): 5690. http://dx.doi.org/10.3390/ijms20225690.

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The mechanisms regulating vascular smooth muscle cell (VSMC) phenotype switching and the critical signal modulation affecting the VSMCs remain controversial. Physical exercise acts as an effective drug in preventing elevated blood pressure and improving vascular function. This study was designed to explore the influence of aerobic exercise on the suppression of VSMC phenotype switching by balancing of the Akt, also known as PKB (protein kinase B) and mitogen-activated protein kinase (MAPK) signaling pathways. Spontaneously hypertensive rats (SHRs) and normotensive rats were subjected to exerci

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16

Nayak, Bob N., William A. Wiltshire, Ben Ganss, Howard Tenenbaum, Christopher A. G. McCulloch, and Charles Lekic. "Healing of Periodontal Tissues Following Transplantation of Cells in a Rat Orthodontic Tooth Movement Model." Angle Orthodontist 78, no. 5 (2008): 826–31. http://dx.doi.org/10.2319/082807-396.1.

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Abstract Objective: To determine the fate and differentiation of transplanted periodontal ligament (PL) precursor cells and mouse embryonic stem (ES) cells and their relative capacity to regenerate wounded periodontium. Materials and Methods: Orthodontic tooth movement was introduced 24 hours before transplantation of PL or ES cells, and rats were euthanized either 24 hours or 72 hours after cell transplantation. The control rats received either no tooth movement and no cell transplantation or tooth movement and no cell transplantation. Differentiation of transplanted cells was assessed from m

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17

Lin, Chin-Sheng, Po-Shiuan Hsieh, Ling-Ling Hwang, et al. "The CCL5/CCR5 Axis Promotes Vascular Smooth Muscle Cell Proliferation and Atherogenic Phenotype Switching." Cellular Physiology and Biochemistry 47, no. 2 (2018): 707–20. http://dx.doi.org/10.1159/000490024.

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Background/Aims: Hyperlipidemia induces dysfunction in the smooth muscle cells (SMCs) of the blood vessels, and the vascular remodeling that ensues is a key proatherogenic factor contributing to cardiovascular events. Chemokines and chemokine receptors play crucial roles in vascular remodeling. Here, we examined whether the hyperlipidemia-derived chemokine CCL5 and its receptor CCR5 influence vascular SMC proliferation, phenotypic switching, and explored the underlying mechanisms. Methods: Thoracoabdominal aorta were isolated from wild-type, CCL5 and CCR5 double-knockout mice (CCL5–/–CCR5–/–)

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18

Lyle, Alicia N., Ebony W. Remus, Aaron E. Fan, and W. Robert Taylor. "Abstract 202: Hydrogen Peroxide Increases Osteopontin Expression Through Activation of Transcriptional and Translational Pathways." Arteriosclerosis, Thrombosis, and Vascular Biology 32, suppl_1 (2012). http://dx.doi.org/10.1161/atvb.32.suppl_1.a202.

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The occlusion of blood vessels in the setting of cardiovascular disease leads to ischemia, initiating processes that promote neovascularization to restore blood flow and preserve tissue function. Our in vivo studies show that Osteopontin (OPN) is a critical mediator of post-ischemic neovascularization and that ischemia-induced increases in OPN expression are H 2 O 2 -dependent. However, the mechanisms by which H 2 O 2 increases OPN expression are poorly defined. To determine if H 2 O 2 mediates transcriptional, post-transcriptional, and/or translational regulation of OPN expression in vitro, w

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19

Liu, Huan, Hongwei Wang, Sijin Yang, and Dehui Qian. "Downregulation of miR-542-3p promotes osteogenic transition of vascular smooth muscle cells in the aging rat by targeting BMP7." Human Genomics 13, no. 1 (2019). http://dx.doi.org/10.1186/s40246-019-0245-z.

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Abstract Background Aging is believed to have a close association with cardiovascular diseases, resulting in various pathological alterations in blood vessels, including vascular cell phenotypic shifts. In aging vessels, the microRNA(miRNA)-mediated mechanism regulating the vascular smooth muscle cell (VSMC) phenotype remains unclarified. MiRNA microarray was used to compare the expressions of miRNAs in VSMCs from old rats (oVSMCs) and young rats (yVSMCs). Quantitative reverse transcription real-time PCR (qRT-PCR) and small RNA transfection were used to explore the miR-542-3p expression in oVS

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20

Lee, Grace S., Courtney M. Caroti, Giji Joseph, et al. "Abstract 627: Human Osteopontin Isoforms Differentially Promote Neovascularization in Response to Ischemia via Macrophage Recruitment and Survival." Arteriosclerosis, Thrombosis, and Vascular Biology 37, suppl_1 (2017). http://dx.doi.org/10.1161/atvb.37.suppl_1.627.

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Background: Coronary and peripheral artery diseases result in vessel occlusion and ischemia, initiating neovascularization to restore blood flow and preserve function. We previously established that osteopontin (OPN), a matricellular cytokine, is critical to ischemia-induced neovascularization. Unlike rodents, humans express 3 OPN isoforms (a, b, and c); however, the roles of these isoforms in neovascularization and cell migration remain undefined. Methods and Results: Using a murine model of hindlimb ischemia in OPN -/- mice and 1.5x10 6 lentivirus particles expressing OPNa, OPNb or OPNc deli

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21

Shuvy, Mony, Suzan Abedat, Sameh Daher, Michael Valitsky, Ronen Beeri, and Chaim Lotan. "Abstract 5867: The Beneficial Effect of Raloxifene in Aortic Valve Calcification is Associated with Up-Regulation of Gas6-Axl Pathway." Circulation 118, suppl_18 (2008). http://dx.doi.org/10.1161/circ.118.suppl_18.s_1019-c.

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Aortic valve calcification (AVC) is an inflammatory regulated process. Growth arrest-specific 6 (Gas6) is involved in atherosclerosis and inflammation; in addition the Gla domain of Gas6 directly inhibits mineralization. We sought to assess the role of Gas6 in AVC using our unique animal model of reversible AVC based on a uremia-inducing diet. We also evaluated the possible role of raloxifene (a selective estrogen modulator), which has demonstrated anti inflammatory effects on blood vessels, in the pathogenesis of AVC. Aortic valves were obtained from four groups of rats (n=10 each): calcified

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