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Journal articles on the topic 'Osteoporosis Osteoporosis Bone density. Ben'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Bellido, M., L. Lugo, S. Castañeda, et al. "PTH Increases Jaw Mineral Density in a Rabbit Model of Osteoporosis." Journal of Dental Research 89, no. 4 (2010): 360–65. http://dx.doi.org/10.1177/0022034510363082.

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Intermittent parathyroid hormone (PTH) administration has been shown to be a promising therapy for systemic bone loss. Accordingly, we hypothesized that PTH could have positive results in treating oral complications of osteoporosis. Hence, we evaluated both mandibular bone loss and its response to PTH in a rabbit model of osteoporosis induced by ovariectomy and glucocorticoid administration. There was a significant and marked decrease in bone mineral density (BMD), bone mineral content (BMC), and calcium content in ash from the osteoporotic peri-alveolar region, which influenced global jaw los

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Kakehasi, Adriana M., Cláudia M. C. Mendes, Luiz G. V. Coelho, Luiz P. Castro, and Alfredo J. A. Barbosa. "The presence of Helicobacter Pylori in postmenopausal women is not a factor to the decrease of bone mineral density." Arquivos de Gastroenterologia 44, no. 3 (2007): 266–70. http://dx.doi.org/10.1590/s0004-28032007000300016.

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BACKGROUND: Osteoporosis affects approximately 30% of postmenopausal women. Gastrectomy, pernicious anemia, and more recently Helicobacter pylori infection, have all been implicated in the pathogenesis of osteoporosis. A reduced parietal cell mass is a common feature in these conditions. AIM: To study a possible relationship between chronic gastritis, parietal cell density of the oxyntic mucosa and bone mineral density in postmenopausal women, as chronic gastritis, Helicobacter pylori infection and osteoporosis are frequently observed in the elderly. METHODS: Fifty postmenopausal women (61.7 ±

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Ciornei, M., Emese Orban, and Remus Şipoş. "Correlations of lipid metabolism with bone remodeling." Medic.ro 6, no. 1 (2020): 28–30. http://dx.doi.org/10.26416/med.138.6.2020.3996.

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Introduction. Both dyslipidemia and osteoporosis are chronic medical problems, and the relationship between these two pathologies is based on common risk factors and pathogenic mechanisms which favour the development of both diseases. Dyslipidemia can be a risk factor for osteoporosis, therefore it is important to understand the mechanisms underlying the relation between these two pathologies. The link between dyslipidemia and osteoporosis. Lipoprotein oxidation products suppress the differentiation of osteoblasts while stimulating the differentiation of adipocytes and their proliferat

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Jaghsi, Sawsan, Taghrid Hammoud, and Shaden Haddad. "Relation Between Circulating Vitamin K1 and Osteoporosis in the Lumbar Spine in Syrian Post-Menopausal Women." Open Rheumatology Journal 12, no. 1 (2018): 1–9. http://dx.doi.org/10.2174/1874312901812010001.

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Background: In the past two decades, Vitamin K has been receiving more attention due to its role in bone health and metabolism. The bone mineral density does not remain steady with age, particularly declining after menopause. Objective: This study is aimed to investigate the relationship between bone mineral density and serum vitamin K1 levels in post-menopausal women, and to evaluate serum vitamin K1 levels as a potential biomarker for postmenopausal osteoporosis. Methods: Serum levels of vitamin k1 were measured in 23 postmenopausal osteoporotic women, and in 15 postmenopausal healthy contro

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Kobza, Alexandra O., Alexandra Papaioannou, Arthur N. Lau, and Jonathan D. Adachi. "Romosozumab in the treatment of osteoporosis." Immunotherapy 12, no. 13 (2020): 965–81. http://dx.doi.org/10.2217/imt-2020-0158.

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Osteoporosis is a disease characterized by weakening of the bone architecture, which leads to an increased risk of fracture. There has been interest in the development of osteoanabolic agents that can increase bone mass and reverse the deteriorating architecture of osteoporotic bone. Romosozumab is a new agent for osteoporosis that both promotes bone formation and inhibits bone resorption. It is a monoclonal antibody that inhibits the activity of sclerostin, which allows the Wnt pathway to promote osteoblastogenesis and inhibit the activity of bone-resorbing osteoclasts. In clinical trials, it

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Stewart, TL, and SH Ralston. "Role of genetic factors in the pathogenesis of osteoporosis." Journal of Endocrinology 166, no. 2 (2000): 235–45. http://dx.doi.org/10.1677/joe.0.1660235.

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Osteoporosis is a common disease with a strong genetic component characterised by low bone mass, microarchitectural deterioration of bone tissue and an increased risk of fracture. Twin and family studies have shown that genetic factors play an important role in regulating bone mineral density and other determinants of osteoporotic fracture risk, such as ultrasound properties of bone, skeletal geometry and bone turnover. Osteoporosis is a polygenic disorder, determined by the effects of several genes, each with relatively modest effects on bone mass and other determinants of fracture risk. It i

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Gerstner, Gregory, Mary Lou Damiano, Angela Tom, et al. "Decreased Bone Mineral Density among Patients with Hemophilia." Blood 110, no. 11 (2007): 1153. http://dx.doi.org/10.1182/blood.v110.11.1153.1153.

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Abstract Background: Osteoporosis among adult males is a major and under-recognized problem in the United States. Patients with hemophilia have several predisposing risks for developing decreased bone mineral density (BMD) and osteoporosis, and may represent an important group to target for screening and treatment for fracture prevention. Patients and Methods: Patients over the age of 18 with moderate or severe hemophilia A or B (as defined by factor activity < 5%) and no history of prophylactic factor use prior to age 10 were eligible. Bone mineral densities were obtained using DEXA scans

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Park, Eunkuk, Chang Gun Lee, Jeonghyun Kim, et al. "Anti-Osteoporotic Effects of the Herbal Mixture of Cornus officinalis and Achyranthes japonica In Vitro and In Vivo." Plants 9, no. 9 (2020): 1114. http://dx.doi.org/10.3390/plants9091114.

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Osteoporosis is a porous bone disease caused by bone density loss, which increases the risk of fractures. Cornus officinalis (CO) and Achyranthes japonica (AJ) have been used as traditional herbal medicine for various disorders in East Asia. Although the anti-osteoporotic effects of single extract of CO and AJ have already been reported, the synergistic effect of a combined mixture has not been studied. In this study, we investigated the effects of a CO and AJ herbal mixture on osteoporosis in in vitro and in vivo models. The results demonstrate that treatment with the CO and AJ mixture signif

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Noble, Jane A., Malachi J. McKenna, and Rachel K. Crowley. "Should denosumab treatment for osteoporosis be continued indefinitely?" Therapeutic Advances in Endocrinology and Metabolism 12 (January 2021): 204201882110100. http://dx.doi.org/10.1177/20420188211010052.

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Denosumab was approved for the treatment of postmenopausal osteoporosis in 2010, based on the FREEDOM study, which indicated a benefit in terms of increased bone mineral density and reduced risk of major osteoporotic fracture. In the initial clinical studies it was noted that discontinuation of denosumab can lead to a rebound of bone turnover markers and loss of accrued bone mineral density. An increased risk of fractures (multiple vertebral fractures in particular) associated with discontinuation was noted after approval and marketing of denosumab. For many patients experiencing gain in bone

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Alam, M. Faiyaz, M. Azmat Rana, and M. Shamshad Alam. "Osteocalcin, a promising marker of osteoporosis: evaluation in post-menopausal females with osteoporosis." International Journal of Advances in Medicine 6, no. 6 (2019): 1746. http://dx.doi.org/10.18203/2349-3933.ijam20194639.

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Background: Osteocalcin, has high affinity for calcium. In osteoporotic women, deficiency of calcium may lead to lowering of the formation of hydroxyapatite crystals. Thus, in the state of hypo mineralization, free osteocalcin available in the circulation. Therefore, present study was designed to evaluate significance of serum osteocalcin in diagnosis of osteoporosis, and relationship between Serum Osteocalcin and BMD (Bone mineral Density) in post-menopausal females with osteoporosis and without osteoporosis.Methods: One hundred and forty seven post-menopausal women between age 45 to 80 years

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Wang, Ning, Dongxing Xie, Jing Wu, et al. "Selenium and bone health: a protocol for a systematic review and meta-analysis." BMJ Open 10, no. 10 (2020): e036612. http://dx.doi.org/10.1136/bmjopen-2019-036612.

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IntroductionBone health affects the ability of human body to stay active, and its degradation can cause considerable morbidity and mortality. The factors related to bone health play an important role in preventing osteoporosis and its adverse consequences. However, the risk factors for osteoporosis have not been fully elucidated. Deficiency in the trace element selenium may be one of the risk factors for the development of osteoporosis. Previous studies have investigated the effects of selenium on osteoporosis; however, the results are inconclusive. Therefore, the present study aimed to system

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Tasci, Ilker, Bilgin Bahadir Basgoz, Umit Cintosun, Umut Safer, and Mehmet Ilkin Naharci. "Age at First Osteoporosis Screening Among Older Women and Men: Is Bone Mineral Density Measurement Ordered Timely?" Endocrine, Metabolic & Immune Disorders - Drug Targets 19, no. 4 (2019): 534–40. http://dx.doi.org/10.2174/1871530319666181226125756.

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Background: US National Osteoporosis Foundation has specified age cut-offs for osteoporosis screening in older women and men. Objective: In this study, we investigated whether Turkish seniors undergo their first ever osteoporosis screening early, on time or late. Methods: We determined the age of older women and men at their first-time Bone Mass Densitometry (BMD) testing using the medical records of a geriatric outpatient unit. The timing of the BMD test was considered ‘’late’’ when performed after the age of 65 and 70 in women and men, respectively. An “early” screening was defined as having

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Sun, Bo, Tian Su, Zhibin Meng, and Songjie Tang. "Anhuienoside C Ameliorates Osteoclast Differentiation in Ovariectomy-Induced Osteoporosis by Regulating RANKL/Wnt Signaling Pathways." Current Topics in Nutraceutical Research 20, no. 1 (2020): 51–55. http://dx.doi.org/10.37290/ctnr2641-452x.20:51-55.

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Postmenopausal and ovariectomy-induced osteoporosis is the most common bone disorder. While pharmacotherapy has been valuable in the management of osteoporosis, it has been associated with undesired side effects. Plant bioactives with minimal side effects have been seen as adjunct to classical therapy. Herein, we have evaluated the protective effect of anhuienoside C (AC) in a rat model of ovariectomy-induced osteoporosis. The treatment of osteoporotic rats with AC caused dose-dependent favorable changes in biochemical markers of bone formation and metabolism (osteocalcin, C-telopeptide of typ

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Batteux, Benjamin, Sandra Bodeau, Camille André, et al. "Association between Uremic Toxin Concentrations and Bone Mineral Density after Kidney Transplantation." Toxins 12, no. 11 (2020): 715. http://dx.doi.org/10.3390/toxins12110715.

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Although uremic osteoporosis is a component of mineral and bone disorder in chronic kidney disease, uremic toxin (UT) concentrations in patients with end-stage kidney disease and bone mineral density (BMD) changes after kidney transplantation have not previously been described. We hypothesized that elevated UT concentrations at the time of transplantation could have a negative impact on bone during the early post-transplantation period. Hence, we sought to determine whether concentrations of UTs (trimethylamine-N-oxide, indoxylsulfate, p-cresylsulfate, p-cresylglucuronide, indole-3-acetic acid

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You, Li, Ling Pan, Lin Chen, Wensha Gu, and Jinyu Chen. "MiR-27a is Essential for the Shift from Osteogenic Differentiation to Adipogenic Differentiation of Mesenchymal Stem Cells in Postmenopausal Osteoporosis." Cellular Physiology and Biochemistry 39, no. 1 (2016): 253–65. http://dx.doi.org/10.1159/000445621.

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Background/Aims: Osteoporosis is a progressive bone disease characterized by a decrease in bone mass and density, which results in an increased risk of fractures. Mesenchymal stem cells (MSCs) are progenitor cells that can differentiate into osteoblasts, osteocytes and adipocytes in bone and fat formation. A reduction in the differentiation of MSCs into osteoblasts contributes to the impaired bone formation observed in osteoporosis. MicroRNAs (miRNAs) play a regulatory role in osteogenesis and MSC differentiation. MiR-27a has been reported to be down-regulated in the development of osteoporosi

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Jadžić, Jelena, and Danijela Đonić. "Compromised bone strength in patients with alcoholic liver cirrhosis." Medicinski podmladak 71, no. 4 (2020): 27–34. http://dx.doi.org/10.5937/mp71-27443.

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Osteoporosis and/or osteopenia are frequently observed complications in alcoholic liver disease patients, especially in its irreversible stage (alcoholic liver cirrhosis - ALC). Current literature review regarding osteoporosis incidence increased fracture risk, bone mineral density changes, micro-structural alteration and pathogenetic mechanisms leading to ALC - induced decrease in bone quality is presented. It has been reported that osteoporosis is influenceing significant number of ALC patients, with particular accent on lumbar spine, as most commonly affected skeletal site. Several risk fac

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17

Kim, Hyojune, Wonhee Lee, SeungHyun Choi, et al. "Role of Additional Inferomedial Supporting Screws in Osteoporotic 3-Part Proximal Humerus Fracture: Finite Element Analysis." Geriatric Orthopaedic Surgery & Rehabilitation 11 (January 1, 2020): 215145932095695. http://dx.doi.org/10.1177/2151459320956958.

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Introduction: Importance of inferomedial supporting screws in preventing varus collapse has been investigated for the proximal humerus fracture. However, few studies reported the results of osteoporotic complex fracture. This study aimed to demonstrate the stress distribution pattern, particularly in osteoporotic 3-part proximal humerus fractures involving greater tuberosity (GT) with different screw configurations. Materials and methods: Using the computed tomography (CT) images of 2 patients, who had osteoporosis and the other had normal bone density, 3-part fractures involving the GT, witho

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Prather, Caitlin, Erin Adams, and Whitney Zentgraf. "Romosozumab: A first-in-class sclerostin inhibitor for osteoporosis." American Journal of Health-System Pharmacy 77, no. 23 (2020): 1949–56. http://dx.doi.org/10.1093/ajhp/zxaa285.

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Abstract Purpose The purpose of this article is to review the pharmacology, efficacy, and safety of the sclerostin inhibitor romosozumab for the treatment of osteoporosis, including data from clinical trials of the drug. Summary A review of the literature was performed by searching PubMed and MEDLINE for all relevant articles published between January 2014 and February 2020 using the keywords romosozumab, romosozumab-aqqg, osteoporosis, and fracture. All relevant English-language articles evaluating the pharmacology, efficacy, or safety of romosozumab for the treatment of osteoporosis in human

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Patil, Kavita Avinash, K. V. Mahendra Prashanth, and A. Ramalingaiah. "Detection of osteoporosis in lumbar spine [L1-L4] trabecular bone: a review article." International Journal of Research in Orthopaedics 7, no. 4 (2021): 872. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20212440.

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<p class="abstract">The human bones are categorized based on elemental micro architecture and porosity. The porosity of the inner trabecular bone is high that is 40-95% and the nature of the bone is soft and spongy where as the cortical bone is harder and is less porous that is 5 to 15%. Osteoporosis is a disease that normally affects women usually after their menopause. It largely causes mild bone fractures and further stages lead to the demise of an individual. This analysis is on the basis of bone mineral density (BMD) standards obtained through a variety of scientific methods experim

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Hassan, Nayera E., Sahar A. El-Masry, Rokia A. El-Banna, and Mohamed S. El Hussieny. "Different Tools for the Assessment of Bone Mass among Egyptian Adults." Open Access Macedonian Journal of Medical Sciences 2, no. 4 (2014): 557–61. http://dx.doi.org/10.3889/oamjms.2014.100.

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BACKGROUND: Several tools such as, dual X-ray absorptiometry (DXA), quantitative computed tomography (QCT) and self-assessment tool (OST), are being used for diagnosis of osteoporosis.OBJECTIVE: to compare the sensitivity and specify detection rate of bone mineral density (BMD) changes for DXA versus QCT and OST among a sample of Egyptian adults of both sexes.SUBJECTS AND METHODS: This study is a cross sectional one, which included 62 Egyptians, aged 20-65 years. Each individual was assessed for BMD using DXA at femur and spine sites; QCT and OST which take into account body weight and age. Ac

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Puspita Sari, Ratna Dewi, and Samsul Bakrie. "Utilization of Isoflavones with Basic Material of Robusta Coffee Skin with BMD (Bone Marrow Density) Markers in Peri / Post Menopausal Women." Biomedical Journal of Indonesia 5, no. 3 (2019): 100–105. http://dx.doi.org/10.32539/bji.v5i3.8684.

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The increase in life expectancy of women in Indonesia, which reaches 72 years of age causes almost a third of her life span lived at the time of menopause. The population of menopausal women in Indonesia will increase with all the effects due to decreased estrogen in the form of climatic complaints and an increased risk of bone loss / osteoporosis. The best choice and is the standard treatment for climatic complaints and osteoporosis is hormonal therapy (Estrogen + Progesterone / Estrogen). WHI in 2004 stated that hormone therapy in menopausal women increases the risk of breast cancer. In Indo

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Ibrahim, Muhammad Huda Ramadhan, Abdullah Hasib Hasib, Siti Nur Rohmah, Salsabilla Abani, Samsi Yordan, and Ira Sari Yudaniayanti. "Utilization of Honey Apis dorsata as Antiosteoporosis on Requirements of Bone Calcium Ash Density on Ovariohysterectomized White Rat (Ratus norvegicus)." KnE Life Sciences 3, no. 6 (2017): 627. http://dx.doi.org/10.18502/kls.v3i6.1191.

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The purpose of this study was to determine the effect of honey bee Apis dorsata as anti-osteoporosis in calcium ash density (CAD) of bone in osteoporotic-induced rats. The target of this study was to know bone calcium levels after being given honey bees Apis dorsata. In this study, 35 female white rats (Ratus norvegicus) mature was used with weight 200gr. Divided into 5 groups, 2 control groups and 3 treatment groups. The negative control group (SH) was not induced by osteoporosis and was given the only aquadest of 1.5 ml/day. Whereas the positive control group was induced by osteoporosis (OH)

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Ralston, Stuart H. "Genetics of osteoporosis." Proceedings of the Nutrition Society 66, no. 2 (2007): 158–65. http://dx.doi.org/10.1017/s002966510700540x.

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Osteoporosis is a common disease with a strong genetic component characterised by reduced bone mass and an increased risk of fragility fractures. Twin and family studies have shown that genetic factors contribute to osteoporosis by influencing bone mineral density (BMD), and other phenotypes that are associated with fracture risk, although the heritability of fracture itself is modest. Linkage studies have identified several quantitative trait loci that regulate BMD but most causal genes remain to be identified. In contrast, linkage studies in monogenic bone diseases have been successful in ge

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Martin, Andrew C. "Osteoporosis in Men." Journal of Pharmacy Practice 24, no. 3 (2011): 307–15. http://dx.doi.org/10.1177/0897190010397716.

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The prevalence of osteoporosis is estimated to be 18% in men, but 30% of all fractures occur in men. With age, men experience a gradual decline in testosterone production and bone density. The rate of trabecular bone loss in the lumbar spine in men over age 50 can be double the rate of loss in men under age 50. Endogenous testosterone, estradiol, and their metabolites play a role in maintaining bone health, but their specific effects on bone turnover have been difficult to elucidate. Recently, large cohort studies have provided more detailed information confirming estrogen’s associations and f

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Szamosi, Szilvia, Ágnes Horváth, Zoltán Szekanecz, and Gabriella Szűcs. "D-vitamin-anyagcsere és osteoporosis szisztémás sclerosisban." Orvosi Hetilap 158, no. 32 (2017): 1252–58. http://dx.doi.org/10.1556/650.2017.30816.

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Abstract: In the past few years more and more data have become available on the important role of vitamin D in immunological processes and inflammation. The role of vitamin D deficiency in the pathogenesis as well as in disease progression of different autoimmune and inflammatory conditions is suspected. Vitamin D deficiency is prevalent in several autoimmune diseases, including systemic sclerosis. Hypovitaminosis has been found to be associated with low bone mineral density and higher prevalence of osteoporosis in this group of patients. Determinants of low bone density in SSc are poorly unde

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Diaz-Coronado, J. C., S. Herrera, D. Hernandez-Parra, et al. "SAT0463 SEVERE OSTEOPOROSIS IN COLOMBIAN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1188.2–1189. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6582.

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Background:Osteoporosis predominantly affects post-menopausal women. There is an important percentage of the population that have additional risk factors that decrease bone mineral density. Patients with Systemic Lupus Erythematosus (SLE) have an increased risk for osteoporosis due to corticosteroid use and chronic inflammation. This population could have a higher prevalence of osteoporosis when compared to post-menopausal women of equal or older age. There is a paucity of information regarding bone mineral density and SLE in Latin America.Objectives:To describe the prevalence and incidence of

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Nordin, BE Christopher. "Nutrition and osteoporosis." British Menopause Society Journal 6, no. 2 (2000): 48–53. http://dx.doi.org/10.1258/136218000322648301.

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Osteoporosis is best defined in terms of whole bone density (apparent density) and is present when this variable falls below the young normal range. Low bone density may be genetically determined or acquired. If acquired it may in principle be due to low bone formation or high resorption. It is most easily produced in experimental animals by calcium deprivation and/or ovariectomy, both of which induce high bone resorption; their effects are additive. The postmenopausal rise in bone resorption is associated with a fall in calcium absorption and a renal tubular leak of calcium which combine to i

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Eller-Vainicher, Cristina, Alberto Falchetti, Luigi Gennari, et al. "DIAGNOSIS OF ENDOCRINE DISEASE: Evaluation of bone fragility in endocrine disorders." European Journal of Endocrinology 180, no. 6 (2019): R213—R232. http://dx.doi.org/10.1530/eje-18-0991.

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An underlying disease affecting bone health is present in up to 40 and 60% of osteoporotic postmenopausal women and men respectively. Among the disorders leading to a secondary form of osteoporosis, the endocrine diseases are highly represented. A frequent finding in patients affected with an endocrine-related forms of bone disease is that the skeletal fragility is partially independent of the bone density, since the fracture risk in these patients is related more to a reduction of bone quality than to a decrease of bone mass. As a consequence, bone mineral density evaluation by dual-X-ray abs

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Yıldırım, Murat, Sinan Saral, Tolga Mercantepe, et al. "White Tea Reduced Bone Loss by Suppressing the TRAP/CTX Pathway in Ovariectomy-Induced Osteoporosis Model Rats." Cells Tissues Organs 209, no. 1 (2020): 64–74. http://dx.doi.org/10.1159/000507791.

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Osteoporosis is an important skeletal disease characterized by bone weakness and high risk of fracture in postmenopausal women. Tea consumption is known to play an important role in the prevention or alleviation of osteoporosis. However, the therapeutic effects of aqueous extracts of white tea (WT) have not been evaluated in osteoporosis rat models. The aim of this study was to investigate the potential anti-osteoporotic role of WT in ovariectomized (OVX) rats. WT was given orally at 0.5% w/v doses for 12 weeks in OVX rats. Biochemical parameters in blood samples, bone tartrate-resistant acid

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Brown, Matthew A., and Emma L. Duncan. "Genetic studies of osteoporosis." Expert Reviews in Molecular Medicine 1, no. 14 (1999): 1–18. http://dx.doi.org/10.1017/s1462399499000964.

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Osteoporosis is a common condition of men and women, which is characterised by an increase in bone fragility due to a reduction in the amount of bone tissue. Predisposition to osteoporosis is largely genetically determined, and it is likely that several genes, each having a small effect, are involved. Bone density is determined by the peak bone mass achieved, and the rate and timing of subsequent bone loss. Twin and family studies suggest that the genetic determinants of bone density in later life influence predominantly, but not exclusively, peak bone mass. Although many genes influence bone

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Rakieh, C., S. Ho, and R. Butler. "SAT0445 TRABECULAR BONE SCORE IMPROVES FRACTURE RISK STRATIFICATION IN PATIENTS WITH REDUCED BONE MINERAL DENSITY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1179.2–1180. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5585.

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Background:Trabecular bone score (TBS) is a textural index of bone microarchitecture and has been found to be related to 3D bone structure. A number of cohort studies have demonstrated the value of TBS as an independent fracture risk in clinical trials. Yet, very little is known about the performance and clinical value of TBS in real life practice.Objectives:To investigate the sensitivity and specificity of TBS in identifying prevalent fractures when compared with bone mineral density (BMD) measured by DXA. To evaluate the added value of TBS in fracture risk prediction above that obtained from

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Fukumoto, Seiji, and Toshio Matsumoto. "Recent advances in the management of osteoporosis." F1000Research 6 (May 5, 2017): 625. http://dx.doi.org/10.12688/f1000research.10682.1.

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There has been substantial progress in the management of patients with osteoporosis and the prevention of osteoporotic fractures. Currently available strong anti-resorptive agents are bisphosphonates and an anti-receptor activator of nuclear factor-kappa B ligand (RANKL) antibody, denosumab. Although bisphosphonates and denosumab both inhibit bone resorption and prevent vertebral and non-vertebral fractures, their mechanisms of action are different. Whereas bisphosphonates’ effects on bone mineral density and fracture peak around 3 to 5 years and become plateaued, those of denosumab are mainta

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O’Donnell, Siobhan. "Screening, prevention and management of osteoporosis among Canadian adults." Health Promotion and Chronic Disease Prevention in Canada 38, no. 12 (2018): 445–54. http://dx.doi.org/10.24095/hpcdp.38.12.02.

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Introduction This study provides a benchmark for the nationwide use of osteoporosis screening, prevention and management strategies among Canadians aged 40 years and older (40+) using data collected one year prior to the release of Osteoporosis Canada’s latest (2010) clinical practice guidelines. Methods Data are from the 2009 Canadian Community Health Survey—Osteoporosis Rapid Response Component. The study sample (n = 5704) was divided into four risk subgroups: (1) osteoporosis diagnosis and major fracture; (2) osteoporosis diagnosis only; (3) major fracture only; or (4) neither osteoporosis

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Wang, Jing, Bing Shu, Chen-Guang Li, et al. "Polymorphisms of genes related to vitamin D metabolism and transportation and its relationship with the risk of osteoporosis: protocol for a multicentre prospective cohort study in China." BMJ Open 9, no. 11 (2019): e028084. http://dx.doi.org/10.1136/bmjopen-2018-028084.

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IntroductionOsteoporotic fracture is one of the most common causes of disability and a major contributor to medical care costs in many regions of the world. The polymorphisms of genes related to vitamin D metabolism and transportation are associated with variation in bone mineral density and the risk of osteoporosis.Methods and analysisThe China Community-based Cohort of Osteoporosis study is an observational, longitudinal, multicentre, prospective cohort study for middle-aged and older permanent residents of China, which has been ongoing in six cities since 2016. Female residents aged 45–80 y

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Yao, F. A., A. S. Dobs, and T. T. Brown. "Alternative Therapies for Osteoporosis." American Journal of Chinese Medicine 34, no. 05 (2006): 721–30. http://dx.doi.org/10.1142/s0192415x06004235.

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A variety of common complementary and alternative medicine therapies are now being examined for effectiveness in the management of osteoporosis. Short-term studies in postmenopausal women show beneficial effects of soy isoflavone supplementation on bone density, but its long-term effects require clarification. Prospective controlled trials have shown that physical training can increase bone density to varying degrees. Other therapies that have been examined include herbal formulae, essential fatty acids and vitamins A, C, and K, but few data regarding their effectiveness, mechanisms and safety

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Mizutani, Kento, Kana Isono, Yoshiaki Matsushima, et al. "Inflammatory Skin-Derived Cytokines Accelerate Osteoporosis in Mice with Persistent Skin Inflammation." International Journal of Molecular Sciences 21, no. 10 (2020): 3620. http://dx.doi.org/10.3390/ijms21103620.

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Secondary osteoporosis can also be caused by chronic inflammatory skin disease as well as rheumatoid arthritis or inflammatory bowel disease. However, the exact role of osteoporosis in inflammatory skin conditions has not been elucidated. Using a mouse model of dermatitis, we investigated the pathophysiology of osteoporosis in inflammatory skin conditions and the therapeutic impact of osteoporosis medication on inflammatory skin disease. We employed model mice of spontaneous skin inflammation, specifically overexpressing human caspase-1 in the epidermis. Bone density and the expression of vari

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Lirani-Galvão, Ana Paula Rebucci, and Marise Lazaretti-Castro. "Physical approach for prevention and treatment of osteoporosis." Arquivos Brasileiros de Endocrinologia & Metabologia 54, no. 2 (2010): 171–78. http://dx.doi.org/10.1590/s0004-27302010000200013.

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Osteoporosis and its consequent fractures are a major problem in public health. To complement the conventional pharmacological treatment for this metabolic disease, non-pharmacological treatment options have been developed in the last decades. Several studies demonstrate that physical exercise programs including impact exercises, specific strength training, balance and coordination training may maintain or increase spine and hip bone mineral density as well as decrease the frequency of falls among osteoporotic and osteopenic patients. Furthermore, some physical agents such as vibratory platfor

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Ward, Leanne M., David R. Weber, Craig F. Munns, Wolfgang Högler, and Babette S. Zemel. "A Contemporary View of the Definition and Diagnosis of Osteoporosis in Children and Adolescents." Journal of Clinical Endocrinology & Metabolism 105, no. 5 (2019): e2088-e2097. http://dx.doi.org/10.1210/clinem/dgz294.

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Abstract The last 2 decades have seen growing recognition of the need to appropriately identify and treat children with osteoporotic fractures. This focus stems from important advances in our understanding of the genetic basis of bone fragility, the natural history and predictors of fractures in chronic conditions, the use of bone-active medications in children, and the inclusion of bone health screening into clinical guidelines for high-risk populations. Given the historic focus on bone densitometry in this setting, the International Society for Clinical Densitometry published revised criteri

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Griffin, Sarah. "Primary prevention of osteoporosis." InnovAiT: Education and inspiration for general practice 6, no. 3 (2013): 148–54. http://dx.doi.org/10.1177/1755738012467437.

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Osteoporosis is a chronic condition characterized by progressive loss of both bone mass and density. It is the most common bone disease, affecting 70% of women over the age of 80 years, and renders bones brittle and vulnerable to fracture. One in every two women and one in every five men sustain an osteoporosis-related fracture within their lifetime. Most of these fractures occur before a formal diagnosis of osteoporosis has been made; thus there is a clear role for primary prevention in preosteoporotic patients. There are numerous established risk factors for the development of osteoporosis,

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Lau, Tang Ching. "Current Challenges in Osteoporosis Treatment Discontinuation." Singapore Family Physician 47, no. 3 (2021): 17–18. http://dx.doi.org/10.33591/sfp.47.3.u3.

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Osteoporosis is a chronic disease that may require lifelong therapy. Therefore, evidence-based approach regarding the efficacy and safety of long‐term osteoporosis therapy and therapy discontinuation is important. The most important goals for osteoporosis and fragility fracture patients are the recovery of pre-fracture functional level and reduction of fracture risk. There has been increasing consensus that a treat-to-target (T2T) strategy is applicable to osteoporosis and that bone mineral density (BMD) is currently the most clinically appropriate target. However, there is no clear consensus

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Wei, Min, Zhonglin Yang, Ping Li, Yabo Zhang, and Wing Cho Sse. "Anti-Osteoporosis Activity of Naringin in the Retinoic Acid-Induced Osteoporosis Model." American Journal of Chinese Medicine 35, no. 04 (2007): 663–67. http://dx.doi.org/10.1142/s0192415x07005156.

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Isoflavonoids isolated from plants have been confirmed to fight osteoporosis and promote bone health. However, few studies have been conducted to describe the anti-osteoporosis activity of botanical flavonone. Based on the experimental outcomes, we demonstrated the ability of naringin to fight osteoporosis in vitro. We developed a retinoic acid-induced osteoporosis model of rats to assess whether naringin has similar bioactivity against osteoporosis in vitro. After a 14-day supplement of retinoic acid to induce osteoporosis, SD rats were administered naringin. A blood test showed that naringin

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Vaghaiwalla, Z., P. Wasserman, and G. Kaeley. "POS0165 STUDY OF VERTEBRAL AND FEMUR FRACTURE PREVALENCE AND SCANOGRAPHIC BONE ATTENUATION COEFFICIENT OF THE FIRST LUMBAR VERTEBRA IN AN ACADEMIC HOSPITAL SETTING." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 295.1–295. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1475.

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Background:Patients with osteoporosis are prone to suffer fragility fractures leading to an increased risk of future fractures. Detection of osteoporosis has been led by dual energy-ray absorptiometry (DEXA) as the gold standard. However, in acute fracture incidents, DEXA imaging is typically unavailable, and treatment is often delayed. In recent years scanographic bone attenuation coefficient of the first lumbar vertebra (SBAC-L1) on incidental computed tomography (CT) scans of the lumbar spine has been utilized as an alternative assessment of bone density. In particular, SBAC-L1 ≤ 145 HU cor

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Cosman, Felicia. "ANABOLIC THERAPY AND OPTIMAL TREATMENT SEQUENCES FOR PATIENTS WITH OSTEOPOROSIS AT HIGH RISK FOR FRACTURE." Endocrine Practice 26, no. 7 (2020): 777–86. http://dx.doi.org/10.4158/ep-2019-0596.

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Objective: Provide an update regarding anabolic medications for osteoporosis, which are often considered to be the last resort for patients with osteoporosis, after multiple fractures have already occurred and other medications have already been administered. Methods: Literature review and discussion. Results: Recent pivotal trial data for anabolic agents and randomized trials comparing anabolic and antiresorptive medications suggest that three anabolic agents (teriparatide, abaloparatide, and romosozumab) reduce nonvertebral and vertebral fractures faster and to a greater extent than potent a

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Liang, Jinqian, Chong Chen, Hongzhe Liu, et al. "Gossypol Promotes Bone Formation in Ovariectomy-Induced Osteoporosis through Regulating Cell Apoptosis." BioMed Research International 2018 (December 13, 2018): 1–9. http://dx.doi.org/10.1155/2018/3635485.

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Osteoporosis is among the most common forms of age-related diseases, especially for females, which has been a grave public health problem. Drug therapies have shown promising outcomes to promote bone formation and bone density. This study identified a novel potential drug, gossypol, for the treatment of osteoporosis. Treatments of ovariectomy-induced osteoporosis mice with gossypol significantly increased serum osteocalcin and osteoprotegerin (OPG) levels; meanwhile they decreased serum RANKL levels. Microcomputed tomography (microCT) analysis showed that treatment of gossypol improved bone de

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He, Q.-F., H. Sun, L.-Y. Shu, et al. "Radiographic predictors for bone mineral loss." Bone & Joint Research 7, no. 7 (2018): 468–75. http://dx.doi.org/10.1302/2046-3758.77.bjr-2017-0332.r1.

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Objectives Researchers continue to seek easier ways to evaluate the quality of bone and screen for osteoporosis and osteopenia. Until recently, radiographic images of various parts of the body, except the distal femur, have been reappraised in the light of dual-energy X-ray absorptiometry (DXA) findings. The incidence of osteoporotic fractures around the knee joint in the elderly continues to increase. The aim of this study was to propose two new radiographic parameters of the distal femur for the assessment of bone quality. Methods Anteroposterior radiographs of the knee and bone mineral dens

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Francis, R. M. "Management of Corticosteroid-Induced Osteoporosis." British Menopause Society Journal 4, no. 2 (1998): 52–56. http://dx.doi.org/10.1177/136218079800400206.

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The pathogenesis of corticosteroid-induced osteoporosis is different from postmenopausal osteoporosis in that the major abnormality is a reduction in bone formation. Corticosteroids result in a 10–15% overall bone loss leading to an increased risk of fracture. Patients on corticosteroids also appear to fracture at a higher bone density than other postmenopausal women. It may therefore be appropriate to start treatment for osteoporosis in corticosteroid-treated patients at a higher bone density than for other postmenopausal women. The various treatments that have been employed are discussed, in

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Chou, Hsin-Hua, Sao-Lun Lu, Sen-Te Wang, Ting-Hsuan Huang, and Sam Li-Sheng Chen. "The Association between Bone Mineral Density and Periodontal Disease in Middle-Aged Adults." International Journal of Environmental Research and Public Health 18, no. 6 (2021): 3321. http://dx.doi.org/10.3390/ijerph18063321.

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The association between osteoporosis and periodontal disease (PD) has been revealed by previous studies, but there have been few studies on the association in younger adults. We enrolled a total of 7298 adults aged 40 to 44 who underwent PD screening between 2003 and 2008. Data on quantitative ultrasound for the measurement of bone mineral density (BMD) were collected for the diagnostic criteria of osteopenia and osteoporosis. The Community Periodontal Index (CPI) was measured for defining PD. A multiple logistic regression model was used to assess the effect of low bone mass on the risk of PD

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Daga, Mradul Kumar. "Osteoporosis in Chronic Obstructive Pulmonary Disease: More than just a Comorbidity." Journal of Advanced Research in Medicine 07, no. 03 (2020): 7–21. http://dx.doi.org/10.24321/2349.7181.202011.

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Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of mortality and loss of Disability-Adjusted Life-Years (DALYs) worldwide. It often is accompanied by the presence of various systemic comorbidities including osteoporosis which may have an impact on the course of the disease. Osteopenia and osteoporosis are the consequences of loss of Bone Mineral Density (BMD) and have been widely known major comorbidities in COPD patients. Female sex, age, and smoking are common pathogenic factors for both COPD and osteoporosis, other factors such as reduced daily physical activity, m

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Uçan Tokuç, Firdevs Ezgi, Fatma Genç, Abidin Erdal, and Yasemin Biçer Gömceli. "Management of bone metabolism in epilepsy." Ideggyógyászati szemle 74, no. 7-8 (2021): 257–65. http://dx.doi.org/10.18071/isz.74.0257.

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Many systemic problems arise due to the side effects of antiepileptic drugs (AEDs) used in epilepsy patients. Among these adverse effects are low bone mineral density and increased fracture risk due to long-term AED use. Although various studies have supported this association with increased risk in recent years, the length of this process has not been precisely defined and there is no clear consensus on bone density scanning, intervals of screening, and the subject of calcium and vitamin D supplementation. In this study, in accordance with the most current recommendations, our applications an

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Paspaliaris, Vasilis, and George Kolios. "Stem cells in Osteoporosis: From Biology to New Therapeutic Approaches." Stem Cells International 2019 (June 2, 2019): 1–16. http://dx.doi.org/10.1155/2019/1730978.

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Osteoporosis is a systemic disease that affects the skeleton, causing reduction of bone density and mass, resulting in destruction of bone microstructure and increased risk of bone fractures. Since osteoporosis is a disease affecting the elderly and the aging of the world’s population is constantly increasing, it is expected that the incidence of osteoporosis and its financial burden on the insurance systems will increase continuously and there is a need for more understanding this condition in order to prevent and/or treat it. At present, available drug therapy for osteoporosis primarily targ

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