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Relevant bibliographies by topics / Osteoporotic fractures

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Academic literature on the topic 'Osteoporotic fractures'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 June 2025

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Journal articles on the topic "Osteoporotic fractures"

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Lin, Xiaozhen, Yiji Li, Limei Wang, and Qiujiao Liao. "Current Status of Research on Anti-osteoporotic Drug Treatment and Compliance in Patients with Osteoporotic Fractures." Journal of Contemporary Medical Practice 6, no. 6 (June 30, 2024): 7–11. http://dx.doi.org/10.53469/jcmp.2024.06(06).02.

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Osteoporotic Fracture (OPF), also known as fragility fracture, is a low-energy, non-violent fracture that commonly occurs in the elderly. Such fractures mostly occur in the thoracolumbar vertebral body, hip, distal radius and other parts, and are the main factors that cause osteoporosis patients to be hospitalized for diagnosis and treatment. Secondary fractures are prone to occur after fractures, and anti-osteoporotic treatment can effectively prevent further fractures in patients with osteoporotic fractures. Due to factors such as patients and their families’ insufficient understanding of the necessity of anti-osteoporosis drug treatment after fragility fractures, insufficient awareness of the risk of re-fracture, lack of follow-up management of drug compliance after treatment, and untimely monitoring of anti-osteoporosis efficacy, etc. The treatment initiation rate and medication compliance of anti-osteoporosis drugs in patients with osteoporotic fractures are low. This article systematically reviews the incidence and disease burden of osteoporotic fractures, the understanding of diagnosis, treatment and management of osteoporotic fractures, the status of anti-osteoporotic drug treatment and compliance, and efficacy monitoring of patients after osteoporotic fractures. Provide a reference for establishing effective medication compliance management for OPF patients.

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Ahn, Seong Hee, Seongbin Hong, Young J. Suh, Da Hea Seo, Yujin Jeong, Yongin Cho, and So Hun Kim. "ODP087 Dose-dependent effect of long-term statin use on risk of osteoporotic fracture in elderly patients." Journal of the Endocrine Society 6, Supplement_1 (November 1, 2022): A162. http://dx.doi.org/10.1210/jendso/bvac150.331.

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Abstract Introduction Studies have been conducted to assess the association between the use of statin and risk of new onset osteoporosis or osteoporotic fractures, however, they have shown conflicting results. We aimed to investigate the association between statin use and the risk of major osteoporotic fractures in elderly population. Methods In this population cohort study with Korean National Health Insurance Service-Senior Cohort database, a total of 365,656 elderly (≥60 years) without previous history of osteoporosis were included. The patients who did not have a history of statin use in year 2003 were followed from January 2004 to December 2012. Incidences of major osteoporotic fractures and site specific fractures were compared using the Cox proportional hazards model with use the inverse probability weighting method. Results During years follow-up period, 54,959 major osteoporotic fractures occurred; the risk of major osteoporotic fractures was significantly reduced (OR,0.769; 95% CI,0.716-0.826) in statin users compared with that in non-users. Among subtypes of major osteoporotic fracture, a risk reduction with statin therapy was significant for both vertebral fracture (OR,0.701; 95% CI,0.641-0.767) and non-vertebral fracture (OR,0.807; 95% CI,0.726-0.898). Longer duration and higher cumulative dose of statin, defined by cumulative daily defined dose, were negatively associated with the risk of major osteoporotic fracture. Conclusion In this population-based cohort study, the use of statin was associated with significant reduction in the risk of osteoporotic fractures in elderly patients without previous history of osteoporosis. Presentation: No date and time listed

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Lyalina, V. V., I. A. Borshenko, S. V. Borisovskaya, E. A. Skripnichenko, R. V. Binyakovskiy, V. V. Trishina, and I. G. Nikitin. "Acute Osteoporotic Vertebral Fracture. Part 1. Definitions, Clinical Presentation, Pain Assessment, Diagnostic Imaging, Introduction to Differential Diagnosis." Russian Archives of Internal Medicine 12, no. 4 (July 30, 2022): 254–66. http://dx.doi.org/10.20514/2226-6704-2022-12-4-254-266.

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Osteoporosis is a widespread metabolic disease of the skeleton among the elderly. Osteoporotic fractures are significant manifestation of the disease, which can substantially affect the quality of life. The purpose of this article is to review approaches to the management of patients with acute osteoporotic fracture. This article consists of two parts. The first part reviews general information about osteoporosis, clinical course of osteoporotic fracture, differential diagnosis of pain syndrome, methods of visualization of fractures, differential diagnosis of osteoporosis. In the second part, we discuss differential diagnosis of osteoporotic fracture according to the data of imaging methods, non-pharmacologic, pharmacologic and surgical methods of treatment.

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Lyalina, V. V., I. A. Borshenko, S. V. Borisovskaya, E. A. Skripnichenko, R. V. Binyakovskiy, V. D. Solomin, V. V. Trishina, and I. G. Nikitin. "Acute Osteoporotic Vertebral Fracture. Part 2. Differential Diagnostics According to the Data of Imaging Methods. Conservative and Surgical Treatment." Russian Archives of Internal Medicine 12, no. 6 (November 29, 2022): 438–49. http://dx.doi.org/10.20514/2226-6704-2022-12-6-438-449.

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Osteoporosis is a widespread metabolic disease of the skeleton among the elderly. Osteoporotic fractures are significant manifestation of the disease, which can substantially affect the quality of life. The purpose of this article is to review approaches to the management of patients with acute osteoporotic fracture. This article consists of two parts. The first part reviews general information about osteoporosis, clinical course of osteoporotic fracture, differential diagnosis of pain syndrome, methods of visualization of fractures, differential diagnosis of osteoporosis. In the second part, we discuss differential diagnosis of osteoporotic fracture according to the data of imaging methods, non-pharmacologic, pharmacologic and surgical methods of treatment.

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Watts, Nelson B. "Osteoporotic vertebral fractures." Neurosurgical Focus 10, no. 4 (April 2001): 1–3. http://dx.doi.org/10.3171/foc.2001.10.4.13.

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Osteoporosis is a significant public health problem. Vertebral fractures are the most common fracture in patients with osteoporosis, occurring in approximately 750,000 cases each year. The fractures may cause acute or chronic pain, reduce the quality of life, and shorten life expectancy. Several medications are available that reduce the risk of fracture. Vertebroplasty and kyphoplasty (balloon-inflated expansion of collapsed vertebrae followed by injection of bone cement) may reduce or relieve pain in selected patients. Although surgery is rarely necessary for the management of osteoporotic vertebral fractures, it may be indicated for other reasons. No studies have been conducted to determine if the outcome of spinal fusion is different in patients with osteoporosis and, if it is, whether management of the patient's osteoporosis will improve the outcome.

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Romanov, G. N., N. F. Chernova, T. I. Moskvicheva, and E. V. Rudenko. "CLINICAL AND INSTRUMENTAL CHARACTERISTICS OF REPEATED OSTEOPOROTIC FRACTURES IN PATIENTS OF GOMEL REGION OF BELORUSSIA AND MODERN THERAPEUTIC STRATEGY." Osteoporosis and Bone Diseases 17, no. 2 (December 15, 2014): 22–25. http://dx.doi.org/10.14341/osteo2014222-25.

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Introduction. Experienced osteoporotic fractures are a significant predictor of repeated, more severe fractures, entailing reduced quality of life and its expectancy. Objectives. To study the clinical and instrumental data of patients with single and repeated osteoporotic fractures of the forearm, proximal femur and spine, as well as the frequency of their occurrence in women of Gomel region of Belorussia. Materials and methods. The study included 2356 women aged over 50 years. Protocol included questionnaire with the assessment of detailed fracture data, medical history and Charlson comorbidity index calculation, quantitative assessment of bone mineral density (BMD) by dual-energy X-ray absorptiometry (LUNAR Prodigy, GE, USA). Results. Osteoporotic fractures of the forearm, spine and proximal femur were found in 523 (22%) of women. More than one fracture was revealed in 106 patients of the total number of patients with fractures (20%). The average age of first fracture in patients with multiple fractures was 59.9 years, for second fracture - 63.3 years and for the third fracture - 66.6 years. Most repeated fractures (67%) occurred within the first three years from the time of initial fracture and were not associated with the densitometry data. Despite the presence of multiple osteoporotic fractures, adequate specific therapy of severe osteoporosis was recommended to only every third patient in need of treatment. Conclusions. Every fifth woman over the age of 50 years had experienced an osteoporotic fracture, with the highest risk of re-fracture occurring during the first three years. Mandatory antiosteoporotic therapy is the only effective method of secondary prevention of complications of osteoporosis.

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Oh, Ho-Seok, Sung-Kyu Kim, and Hyoung-Yeon Seo. "Characteristics of Osteoporosis & Osteoporotic Fractures in Korea Based on Health Insurance Review and Assessment (HIRA) Database: 2009–2017." Healthcare 9, no. 3 (March 14, 2021): 324. http://dx.doi.org/10.3390/healthcare9030324.

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To investigate the incidence and characteristics of osteoporosis and osteoporotic fractures in Korea, we used the Health Insurance Review and Assessment Service (HIRA) database. Patients over 50 years old, who were diagnosed or treated for osteoporosis and osteoporotic fractures in all hospitals and clinics, were analyzed between 1 January 2009 and 31 December 2017 by using the HIRA database that contains prescription data and diagnostic codes. These data were retrospectively analyzed by decade and age-specific and gender-specific incidents in each year. We also evaluated other characteristics of patients including medication state of osteoporosis, primary used medical institution, regional-specific incidence of osteoporosis, and incidence of site-specific osteoporotic fractures. The number of osteoporosis patients over 50 years old, as diagnosed by a doctor, steadily increased from 2009 to 2017. The number of osteoporosis patients was notably greatest in the 60′s and 70′s age groups in every study period. Patients undergoing treatment for osteoporosis increased significantly (96%) from 2009 to 2017. Among the patients diagnosed with osteoporosis, the proportion who experienced osteoporotic fracture increased gradually (60%) from 2009 to 2017. The number of patients with osteoporotic fractures of the spine and hip was highest in the 70 to 90 age range, and the number of patients with osteoporotic fractures in the upper and lower extremities was highest in the 50 to 70 age range. Understanding the trends of osteoporosis in Korea will contribute to manage the increased number of patients with osteoporosis and osteoporotic fractures.

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Parathan, S., and T. Gobyshanger. "Pattern of second osteoporotic fractures. A descriptive study in two tertiary care centers in Sri Lanka." Sri Lankan Journal of Orthopaedic Surgery 8, no. 1 (November 1, 2022): 41–53. http://dx.doi.org/10.4038/tsljos.v8i1.7.

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Introduction: Second osteoporotic fractures have higher morbidity and mortality than prior osteoporotic fractures. Materials and methods: A retrospective case series of patients admitted to two tertiary care hospitals with second osteoporotic fractures from April 2020 to March 2021 assessed demography, time since the first osteoporotic fracture, fracture locations, comorbidities, menopausal age, predisposing drugs and habits, parental history, fall risk, BMI, family support and treatment. Results: Fifty-four patients were studied. Forty-nine (90.7%) were females, Mean age was 75.8 years (57-95). Mean time since the first fracture was 3.67 years (3/12-12). Twenty-six (48.1% p 0.00) had second fracture within 2 years since first osteoporotic fracture. Major osteoporotic sites involved in 79.6% of first fractures and 85.1% of second fractures. Proximal femur was the predominantly involved major site in first (23/43 p 0.00007) and second (35/46 p 0.00) fractures. Females who had premature/early menopause were significantly associated with the second fracture before the age of 75 years (10/15 p 0.03) and with non-major site involvement (5/15 p 0.035). Forty-nine (90.7%) patients had fall risk. Forty-seven (87.03%) patients lived with their family. Only 2/54 had DEXA. Patients who were aware of their condition had better compliance for supplements (9/12 p 0.0003). Anti-osteoporotic agent was used by 3/54 patients. Discussion and Conclusion: Female gender, premature/early menopause and prior proximal femur fracture are the main risk factors for second osteoporotic fracture. Following all low energy fractures, immediate osteoporosis diagnostic work up with commencement of anti-osteoporotic regime accordingly and modification of fall risk are recommended to reduce the imminent risk of second osteoporotic fracture occurrence.

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Wang, Yu-Ming, and Ping Yi. "Global current research status and future hotspots in osteoporotic fracture based on bibliometric assessment and visualization techniques." World Journal of Clinical Cases 12, no. 19 (July 6, 2024): 3908–17. http://dx.doi.org/10.12998/wjcc.v12.i19.3908.

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BACKGROUND In the past decade, the evolution of themes in the field of osteoporotic fractures has changed from epidemiology and prediction of long-term morbidity, risk assessment of osteoporotic fractures, and zoledronic acid and denosumab in the treatment of osteoporosis to treatment guidelines for osteoporosis and the side effects caused by anti-osteoporotic drugs. AIM To understand the trends and hotspots in osteoporotic fracture research. METHODS Original articles were retrieved between January 1, 2010, and December 31, 2019, from the Web of Science Core Collection database. CiteSpace software facilitated the analysis and visualization of scientific productivity and emerging trends. RESULTS Nine studies were identified using bibliometric indices, including citation, centrality, and sigma value, which might indicate a growing trend. Through clustering, we identified six major hot subtopics. Using burst analysis, top-5 references with the strongest bursting strength after 2017 were identified, indicating a future hotspot in this field. CONCLUSION Current hot subtopics in osteoporotic fracture research include atypical femoral fractures, androgen deprivation therapy, denosumab discontinuation, hip fractures, trabecular bone score (TBS), and bone phenotype. Management and prevention of secondary fractures in patients with osteoporotic fractures, TBSs, and long-term administration strategy for zoledronic acid are expected to become research hotspots.

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Etibarlı, S. S., R. S. Khalilzadeh, C. N. Iskanderov, and E. S. Hajıyev. "THE PREVALENCE AND INCIDENCE OF OSTEOPOROTIC VERTEBRAL FRACTURES." National Journal of Neurology 1, no. 24 (May 30, 2024): 18–22. https://doi.org/10.61788/njn.v1i24.02.

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Osteoporosis is a skeletal disorder characterized by low bone mass and deterioration of bone tissue with a consequent increase in the fragility of bone and hence susceptibility to fracture. An osteoporotic fracture occurs as a result of fragility of the vertebrae. Acquaintance with the science of osteoporosis and osteoporotic fractures, new hypotheses, theories, classifications, variants, and its comparative analysis in people of different genetic backgrounds in different countries leads to a deeper understanding of the problem. Scientists from different countries of the world have made great contributions to the accurate study, systematization, classification, and epidemiology of pathology. Despite all this, the fact that a part of osteoporotic fractures is asymptomatic and the patients rarely consult a doctor (20-25%), makes it difficult to describe the clinical symptoms. Thus the incidence of vertebral fractures in the general population cannot be accurately determined. At the same time, there is no consensus of criteria for radiologically defining a vertebral fracture. Currently, although various etio-pathogenetic theories and epidemiological studies on osteoporotic fractures are classification options, no unified agreement has been reached on the problem.

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Dissertations / Theses on the topic "Osteoporotic fractures"

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Kaptoge, Stephen Kipkemoi. "Epidemiology of risk factors for osteoporosis and osteoporotic fractures." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615203.

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Misra, Devyani. "Warfarin use and risk of osteoporotic fractures." Thesis, Boston University, 2012. https://hdl.handle.net/2144/21219.

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Thesis (M.S.M.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>OBJECTIVE: Prior studies examining the association of warfarin use and osteoporotic fractures have found conflicting results and have had methodological problems, such as confounding by indication and confounding by duration of warfarin use. Thus, we studied the association of warfarin use with fractures at the hip, spine and wrist, among older men and women with atrial fibrillation recruited from the general population, using rigorous statistical tools to overcome challenges faced by prior studies. METHODS: We included men and women ≥65 years with incident atrial fibrillation, without history of fracture, followed between 2000-2010 from The Health Improvement Network (THIN). Long-term warfarin use was defined in two ways: 1) warfarin use ≥ 1year; 2) warfarin use ≥3 years. Non-use was defined as no use of warfarin over the follow-up period. Propensity scores (PS) for warfarin use were calculated using logistic regression with long-term use of warfarin as the dependent variable and age, sex, body mass index (BMI), history of multiple falls, deep venous thrombosis, pulmonary embolism, heart failure, neuropsychiatric impairment, hyperthyroidism, estrogen use, beta blockers, corticosteroids, bisphosphonates, smoking and alcoholism as independent variables. Each warfarin user was then matched by PS to a non-user by the “greedy matching” method. Incidence rates were calculated for warfarin users and non-users. The association between long-term warfarin use and risk of hip, spine and wrist fractures was evaluated using Cox-proportional hazards models. RESULTS: Incidence rates of hip fracture were 5.21 and 6.20 per 1000 person-years among subjects with warfarin use >1 (n=20,346) and >3 (n=11,238) years, respectively. The hazard ratios of hip fracture for warfarin use >1 and >3 years were 1.08 (95% CI 0.87, 1.35) and 1.13 (95% CI: 0.84, 1.5), respectively. Similar findings were observed between warfarin use and risk of spine or wrist fracture. CONCLUSIONS: Long-term use of warfarin among older adults with atrial fibrillation is not associated with increased risk of osteoporotic fractures and thus, does not necessitate additional surveillance or prophylaxis.<br>2031-01-01

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Tan, Boon-Kiang. "Non-invasive determinants of osteoporotic fracture risk." University of Western Australia. Centre for Musculoskeletal Studies, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0125.

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[Truncated abstract] The cost of managing osteoporotic fractures places a significant financial burden on the health-care system. To reduce the fracture burden, early identification of fracture risk is essential to allow early intervention. The limitations associated with dual-energy X-ray absorptiometry (DXA), such as limited sensitivity and specificity, cost, ionising radiation and accessibility, have resulted in the emergence of other technologies for assessing bone fragility. An example is the portable and non-ionising quantitative ultrasound (QUS) technology. The discriminatory power of quantitative ultrasonometry in fracture risk identification, either independently or in combination with other established risk factors, currently remains contentious. It is recommended that fracture risk assessment should not only focus on bone status, but also on the risk of falls. Additionally, it has been noted that disability arising from osteoporotic fractures, even when these fractures are not identified clinically, can translate into psychosocial symptoms and a poorer perception of health-related quality of life (HRQoL). The primary aim of the present study was to investigate if a composite model comprising: calcaneal QUS, falls risk and HRQoL assessments, can identify a group of elderly women at high risk of osteoporotic fracture from those at lower risk. One hundred and four community-dwelling women (mean age 71.3 ±5.8 years) were recruited for this study. These women underwent a series of tests that included: DXA bone mineral density (BMD) evaluation of the proximal femur and lumbar spine (L1 L4); calcaneal QUS measurement; spinal radiography; rasterstereographic back surface curvature (BSC) examination; and performance-based assessment of strength, mobility and balance. The women were classified into a `High Risk’group or a `Low Risk’ group using three separate classification criteria: i) low BMD, based on the World Health Organisation (WHO) recommended T-score of < -2.5, and⁄or a history of fragility fracture (Osteoporotic [OP] group versus Non-Osteoporotic [NOP] group); ii) presence of at least one radiographically identified prevalent vertebral fracture (Vertebral Fracture [VF] group versus Non-Vertebral Fracture [NVF] group); or iii) a history of either forearm or wrist fracture (Forearm/Wrist Fracture [WF] group versus Non-Forearm/Wrist Fracture [NWF] group)

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Ridzwan, Mohamad. "A computational orthopaedic biomechanics study of osteoporotic hip fractures." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/47971.

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Low dual energy X-ray absorptiometry (DXA) measured bone mineral density (BMD) is used as an indicator of reduced bone strength and increased risk of fracture. BMD is widely used to identify patients for fracture prevention treatment. However, many fracture patients are not osteoporotic and would not have been identified by BMD screening. Also, BMD screening vastly overpredicts the number of patients who will progress to fracture. In summary, there is a need to improve explanation and prediction of femoral fracture. The overall aim of this thesis was to develop a finite element (FE) methodology that can explain (better than BMD) femoral fractures. An additional aim was to develop a novel experimental methodology, computed tomography (CT)-based digital volume correlation (CT-DVC). This method measures internal strain and fracture and served as validation for the FE methodology. The study included three groups of femur specimens; Group 1: 15 cadavers served as non-fracture controls, Group 2: 14 patients who had suffered a femoral fracture and Group 3: 13 patients scheduled for arthroplasty due to osteoarthritis served as a second non-fracture control group. The correlation of FE-predicted fracture load with in-vitro testing of cadaveric femurs was superior to that of BMD predictions (R2 = 0.77 and R2 = 0.59). Also, the match between CT-based FE models and the experimental observations was reasonably good (73% match) whereas BMD is unable to explain the fracture type. FE-predicted fracture types matched 13 of 14 patient-specific clinical fractures. Including bone quality and load (fall) direction, FE explained many of the clinical fractures that BMD was unable to explain and critical fall directions were identified. FE predicted lower strength of the fracture group which was associated with smaller sizes of anatomical parameters. Also the CT- DVC method demonstrated consistent results and was deemed to have great potential for a wide range of orthopaedic applications.

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Korpelainen, R. (Raija). "Exercise and risk factors of osteoporotic fractures in elderly women." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514278054.

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Abstract The aim of this study was to examine lifestyle risk factors for low bone mass, falls and fractures, and to determine the effect of 30-month exercise trial on bone mass, balance, muscle strength and gait in elderly women. Reliability of an inclinometric method for assessing postural sway was evaluated. Data on risk factors, falls and fractures were collected by questionnaires, and calcaneus and radius bone mass were measured from 1,222 women. Lifetime physical activity, low occupational physical activity, type 2 diabetes, hypertension, hormone replacement, thyroid hormone and thiazide use were associated with increased bone mass, while low current physical activity, high coffee intake and late menarche were associated with low bone mass in lean women. Factors associated with fractures were: low lifetime habitual physical activity, diabetes, living alone and calcaneum bone mass. One hundred and sixty women with low femoral neck bone mass were randomly assigned to the exercise group (n = 84) or to the control group (n = 76). The outcomes included radius, proximal femur and calcaneus bone mass, postural sway, muscle strength, gait speed and endurance. Bone mineral density (BMD) at proximal femur decreased in the control group, while no change occurred in the exercise group. Mean trochanter bone mineral content (BMC) decreased more in the control group. The women in the exercise group improved their performance in walking speed and endurance, body sway and leg strength compared to the control group. There were six falls that resulted in fractures in the exercise group and 16 in the control group. The inclinometric method proved to be reliable. In conclusion, lifestyle factors are determinants of bone mass in lean elderly women. Long-term exercise has a site-specific effect on BMC but not on BMD in elderly women. Weight-bearing exercise can modify risk factors for fractures, and may even prevent fall-related fractures in elderly women.

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Hallberg, Inger. "Health-Related Quality of Life in Postmenopausal Women with Osteoporotic Fractures." Doctoral thesis, Linköpings universitet, Omvårdnad, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51524.

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Background: The global burden of osteoporosis includes considerable numbers of fractures, morbidity, mortality and expenses, due mainly to vertebral, hip and forearm fractures. Underdiagnosis and undertreatment are common. Several studies have shown decreased health-related quality of life (HRQOL) after osteoporotic fracture, but there is a lack of data from long-term follow-up studies, particularly regarding vertebral fractures, which are often overlooked despite patients reporting symptoms. Aim: The overall aim of this thesis was to evaluate the usefulness of a recent low-energy fracture as index event in a case-finding strategy for osteoporosis and to describe and analyse long-term HRQOL in postmenopausal women with osteoporotic fracture. The specific aims were to describe bone mineral density and risk factors in women 55-75 years of age with a recent low-energy fracture (I), estimate the impact of osteoporotic fractures on HRQOL in women three months and two years after a forearm, proximal humerus, vertebral or hip fracture (II), investigate the changes and long-term impact of vertebral or hip fracture on HRQOL in women prospectively between two and seven years after the inclusion fracture (III), and describe how HRQOL and daily life had been affected in women with vertebral fracture several years after diagnosis (IV). Design and methods: Data were collected from southern Sweden between 1998 and 2008. A total of 303 women were included in Study I, and this group served as the basis for Studies II (n=303), III (n=67), and IV (n=10). A cross-sectional observational, case-control design (I), and a prospective longitudinal observational design (II-III) were used. In Study IV a qualitative inductive approach with interviews was used and data were analysed using a qualitative conventional content analysis. Results: The type of recent fracture and number of previous fractures are important information for finding the most osteoporotic women in terms of severity (I). Hip and vertebral fractures in particular have a significantly larger impact on HRQOL evaluated using the SF-36 than do humerus and forearm fractures, both during the three months after fracture and two years later, compared between the different fracture groups and the reference population (II). Women who had a vertebral fracture as inclusion fracture had remaining pronounced reduction of HRQOL at seven years. At the mean age of 75.5 years (±4.6 SD), the prevalence of vertebral fracture suggests more negative long-term impact on HRQOL, more severe osteoporosis and a poorer prognosis than a hip fracture does, and this effect may have been underestimated in the past (III). Study IV demonstrates that the women’s HRQOL and daily life have been strongly affected by the long-term impact of the vertebral fracture several years after diagnosis. The women strive to maintain their independence by trying to manage different types of symptoms and consequences in different ways. Conclusions and implications: Type and number of fractures should be taken into account in the case-finding strategy for osteoporosis in postmenopausal women between 55 and 75 years of age. The long-term reduction of HRQOL in postmenopausal women (age span 55-75 yr) with vertebral fracture emerged clearly, compared to women with other types of osteoporotic fractures and references in this thesis. The results ought to be taken into consideration when developing guidelines for more effective fracture prevention and treatment, including non-pharmacological intervention for women with osteoporotic fractures, with highest priority placed on vertebral fractures and multiple fractures, to increase or maintain HRQOL.

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Gao, Xin. "Economic evaluation of three preventive drug therapies for osteoporotic fractures among women at different risk levels." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2045.

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Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains xi, 211 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 171-186).

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Slavens, Melanie Jean. "Milk Intake in Early and Late Adulthood and Risk of Osteoporotic Hip Fractures in Utah." DigitalCommons@USU, 2006. https://digitalcommons.usu.edu/etd/5532.

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The relationship between milk intake and risk of osteoporotic fractures is uncertain. Associations between milk intake and milk avoidance in relation to osteoporotic hip fracture were examined in the Utah Study of Nutrition and Bone Health (USNBH), a statewide case-control study. Cases were ascertained at Utah hospitals treating 98 percent of hip fractures during 1997-2001 and included 1188 men and women aged 50-89 years. Age- and gender-matched controls were randomly selected from Utah driver's license and Medicare databases (N= 1324). In-person interviews were conducted and participants reported frequency of milk intake per week at age 18 and during pregnancy among women who reported being pregnant. Milk avoidance for a period of more than one year and duration of milk avoidance were also reported. Diet and supplement intake in the one-year period before fracture (cases) or the interview (controls) was assessed using a picture-sort food frequency questionnaire. Milk consumption frequency was categorized into four levels of intake at each life stage. Total calcium intake was categorized into quintiles of distribution of intake. Logistic regression models were used to examine associations between milk intake and milk avoidance and risk of hip fracture while controlling for the potential confounding effects of gender, age, body mass index, alcohol use, smoking, physical activity, estrogen use, and total calorie, protein, calcium, and vitamin D intake. Recent milk intake, milk intake during pregnancy, and milk avoidance duration were not associated with risk of hip fracture. A borderline association was found at age 18 showing a decreased risk of hip fracture among those in the highest quartile (2: 15 cups of milk per week) of milk intake (odds ratio (OR): 0.86, 95 percent confidence interval (Cl): 0.75, 1.00; P = 0.046). Milk avoidance for a year or more was associated with an increased risk of hip fracture compared to those who did not avoid milk (OR: 1.38, 95 percent CI: 1.07, 1.78). A significant interaction was found between milk avoidance and quintile of total calcium intake (P = 0.02). Milk avoidance was associated with a significantly higher risk of hip fracture at the lowest two quintiles of calcium intake (OR: 1.72, 95 percent CI: 1.26, 2.17; P = 0.02 and OR: 1.58, 95 percent CI: 1.01, 2.15; P = 0.01, respectively) but was not associated with elevated risk among those with higher calcium intakes. In conclusion, milk intake during pregnancy for women, and in the year before hip fracture (for cases) or before interview (for controls), was not associated with hip fracture risk. The highest level of milk intake at age 18 was associated with decreased risk of hip fracture. Avoidance of milk for one year or more was associated with hip fracture risk, but only among those with low calcium intake (Q1 and Q2).

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Dodds, R. A. "Structural and metabolic studies on normal and pathological bone." Thesis, Brunel University, 1985. http://bura.brunel.ac.uk/handle/2438/4870.

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Bone is refractory to most conventional biochemical Procedures. However because it is now possible to cut sections (e. g. lopm) of fresh, undemineralized adult bone, this tissue can be analyzed by suitably modified methods of quantitative cytochemistry. A new substrate for assaying hydroxyacyl dehydrogenase activity demonstrated that bone cells may use fatty acids as a major source of energy: detailed analysis of the activities of key enzymes indicated that the paradox of ‘aerobic glycolysis’ of bone could be explained by fatty acid oxidation satisfying the requirements of the Krebs' cycle and directing the conversion of pyruvate to lactate The influence of glucose 6-phosphate dehydrogenase (G6PD) activity in aerobic glycolysis has been considered. The inverse relationships between this activity and that of Na-K-ATPase led to the development of a new method for the latter, based on a new concept in cytochemistry ('hidden-capture' procedure). A major feature of fracture-healing is increased periosteal G6PD activity. The association with the vitamin K cycle has been investigated by feeding rats with dicoumarol which not only inhibited bone-formation but also G6PD activity. The stimulation of this activity in fracture-healing has been linked with ornithine decarboxylase (ODC) activity, for which a new method has been developed. Rats deficient in pyridoxal phosphate (cofactor for ODC) had decreased G6PD responses and also appeared to become osteoporotic. Studies on osteoporotic fractures in the human showed the presence of relatively large apatite crystals close to the fracture-site, and disorganized glycosaminoglycans (demonstrated by the new method of ‘induced birefringence’).

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Bienert, Michaela [Verfasser], Wilhelm [Akademischer Betreuer] Jahnen-Dechent, and Sabine [Akademischer Betreuer] Neuß-Stein. "Biologically active bone replacement materials for osteoporotic fractures / Michaela Bienert ; Wilhelm Jahnen-Dechent, Sabine Neuß-Stein." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/1181192919/34.

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Books on the topic "Osteoporotic fractures"

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name, No. Vertebral osteoporotic compression fractures. Philadelphia, PA: Lippincott Williams & Wilkins, 2002.

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Marek, Szpalski, and Gunzburg Robert, eds. Vertebral osteoporotic compression fractures. Philadelphia: Lippincott Williams & Wilkins, 2003.

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Leung, Frankie, and Tak Wing Lau, eds. Surgery for Osteoporotic Fractures. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-9696-4.

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Obrant, Karl, ed. Management of Fractures in Severely Osteoporotic Bone. London: Springer London, 2000. http://dx.doi.org/10.1007/978-1-4471-3825-9.

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Razi, Afshin E., and Stuart H. Hershman, eds. Vertebral Compression Fractures in Osteoporotic and Pathologic Bone. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33861-9.

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Ringe, Johann. Osteoporotic fractures in the elderly: Clinical management and prevention. Stuttgart: Georg Thieme Verlag, 1996.

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Suzanne, Morphet, Canadian Coordinating Office for Health Technology Assessment., and Canadian Agency for Drugs and Technologies in Health., eds. Bisphosphonates and teriparatide for the prevention of osteoporotic fractures in postmenopausal women. Ottawa: Canadian Coordinating Office for Health Technology Assessment, 2006.

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A, Wells George, and Canadian Agency for Drugs and Technologies in Health., eds. Bisphosphonates for the primary and secondary prevention of osteoporotic fractures in postmenopausal women: A meta-analysis. Ottawa: Canadian Agency for Drugs and Technologies in Health, 2006.

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1955-, Schachter Howard M., and Canadian Coordinating Office for Health Technology Assessment., eds. Raloxifene for primary and secondary prevention of osteoporotic fractures in postmenopausal women: A systematic review of efficacy and safety evidence. Ottawa: Canadian Coordinating Office for Health Technology Assessment, 2005.

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Wendlova, Jaroslava. Biomechanical variables in assessment of fracture risk. Hauppauge, N.Y: Nova Science, 2011.

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Book chapters on the topic "Osteoporotic fractures"

1

Bartl, Reiner, and Bertha Frisch. "Osteoporotic Fractures." In Osteoporosis, 165–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-79527-8_23.

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Vialle, Luiz R., and Emiliano N. Vialle. "Osteoporotic Fractures." In Essentials of Spine Surgery, 61–68. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-80356-8_10.

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Lasanianos, Nick G., George K. Triantafyllopoulos, and Spiros G. Pneumaticos. "Osteoporotic Vertebral Fractures." In Trauma and Orthopaedic Classifications, 251–54. London: Springer London, 2014. http://dx.doi.org/10.1007/978-1-4471-6572-9_56.

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Bassani, Julio E., Facundo M. Galich, and Matías G. Petracchi. "Osteoporotic Vertebral Fractures." In Orthopaedics and Trauma, 691–700. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-30518-4_55.

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Tosounidis, Theodoros H., and Michael G. Kontakis. "Osteoporotic ankle fractures." In Surgical and Medical Treatment of Osteoporosis, 261–66. Boca Raton : CRC Press, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429161087-27.

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Ong, Terence, and Opinder Sahota. "Osteoporotic thoracolumbar fractures." In Surgical and Medical Treatment of Osteoporosis, 305–14. Boca Raton : CRC Press, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429161087-31.

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Telera, Stefano, Laura Raus, Valerio Pipola, Federico De Iure, and Alessandro Gasbarrini. "Osteoporotic Vertebral Fractures." In Vertebral Body Augmentation, Vertebroplasty and Kyphoplasty in Spine Surgery, 133–48. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-76555-2_9.

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Gudmundsdottir, Rakel Sif. "The Elderly Osteoporotic Patient." In Distal Radius Fractures, 241–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54604-4_30.

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Fang, Christian. "Proximal Tibial Fractures." In Surgery for Osteoporotic Fractures, 161–81. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-9696-4_11.

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Saleh, Ahmed, and Michael Collins. "Osteoporotic Vertebral Compression Fractures." In Vertebral Compression Fractures in Osteoporotic and Pathologic Bone, 57–62. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33861-9_6.

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Conference papers on the topic "Osteoporotic fractures"

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M Benneker, Lorin. "Osteoporotic Spine Fractures." In eccElearning Postgraduate Diploma in Spine Surgery. eccElearning, 2017. http://dx.doi.org/10.28962/01.3.122.

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Kasra, Mehran, Marc D. Grynpas, Rajka Soric, and Sara Arnaud. "A Clinical Evaluation of Vibration Testing in the Assessment of Osteoporosis." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2587.

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Abstract Bone fracture is one of the most common medical problems which reduces the quality of life of individuals. In the United States, osteoporosis alone causes 1.3 million bone fractures a year, with an annual cost of $5.2 billion dollars. Osteoporosis is a disease in which low bone mass and changes in bone quality and architecture increase the risk of fractures. Women are at greater risk of developing osteoporosis than men. Osteoporosis targets both trabecular and cortical bone (Kanis et al., 1994; Kasra and Grynpas, 1994). Therefore, bone density of cortical bone structures such as ulna and mid-radius may be used as a predictor of osteoporotic fractures (Cummings et al., 1993). Bone quality assessment and predicting the risk of bone fracture is very important in prevention of fracture and proper bone treatment. In the NIH Consensus Development Statement (1984), the need for improved measurement techniques is emphasized.

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Kanziuba, Anatolii, and Petro Popyurkanych. "BONE METABOLISM OF OSTEOPOROTIC INTERTROCHANTERIC FRACTURES." In SCIENTIFIC PRACTICE: MODERN AND CLASSICAL RESEARCH METHODS. European Scientific Platform, 2023. http://dx.doi.org/10.36074/logos-22.12.2023.097.

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Ural, Ani. "Evaluation of Fracture Load in Human Radius via Cohesive Finite Element Modeling." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204316.

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Osteoporotic and age-related fractures are a significant public health problem. One of the most common osteoporotic fracture sites in the aging population is distal radius. There is evidence in the literature that distal radius fractures (Colles’ fracture) are an indicative of increased risk of future spine and hip fractures [1]. Therefore, developing new methods for accurate evaluation of human radius fracture risk is necessary. The previous studies showed that geometrical properties of the radius correlate with its fracture load [2]. However, the combined effect of geometrical and material properties on fracture load has not been studied.

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Natella, LL, N. Bronsard, J. Allia, L. Hekayem, L. Euller-Ziegler, F. De Peretti, and V. Breuil. "FRI0578 Odontoid fractures in the elderly: an unknown osteoporotic fracture?" In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3503.

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de Oliveira, Juliana Silva, and Alexandre dos Santos Gomes. "World of work for graduates of professional education in radiology: Distribution of bone densitometry equipment in the state of Rio de Janeiro." In VI Seven International Multidisciplinary Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/sevenvimulti2024-068.

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Bone densitometry (BD) is essential in medicine to assess bone mineral density (BMD) and diagnose osteoporosis, being non-invasive and crucial in the prevention of osteoporotic fractures. Osteoporosis, characterized by reduced BMD, significantly increases the risk of fractures. Early detection through BD is essential to initiate appropriate treatments and monitor their effectiveness, preventing the progression of the disease. DATASUS uses the National Registry of Health Establishments (CNES) to operationalize data, including BD equipment, facilitating the management and monitoring of these resources.

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Salas, Christina, Deana Mercer, Thomas A. DeCoster, and Mahmoud M. Reda Taha. "Experimental and Probabilistic Finite Element Analysis of Distal Femoral Fractures: A Comparison of Locking Plate Versus Intramedullary Nail Fixation." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19303.

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In the treatment of unstable, distal, metaphyseal femoral fractures, surgeons have multiple implant options for fixation. Biomechanical studies of intramedullary nailing systems and locking plates have shown that both systems achieve stable fixation of the fracture to allow healing.1–3 These systems are indicated for comminuted fractures, non-unions, and osteoporotic bone where distal femur fractures are associated with a 20% mortality rate in elderly individuals.4 Though capable of achieving stable fixation, both locking and non-locking plates have been associated with periprosthetic fractures in osteoporotic and normal bone.4–6 A recent clinical study reported a 2.6% incidence of periprosthetic fractures at the locking plate end.7

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Stratan, DN, M. Popa, O. Alexa, and L. Stratan. "OP0128 Femoral neck fractures in osteoporotic patients." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.507.

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Ferreri, Suzanne, and Yi-Xian Qin. "Dynamic Mechanical Signals Delivered by Ultrasound Generate Site Specific Mediation of Bone Loss." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206219.

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Osteoporosis is a disease characterized by decreased bone mass and progressive erosion of the microstructure. As a result, bone is at higher risk for developing chronic and traumatic fractures at key skeletal sites. Therapeutic ultrasound may offer a potential non-pharmacologic, site-specific intervention for treatment of osteoporotic bone loss.

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Chen, Y.-C., and C.-H. Ko. "FRI0526 Anti-osteoporotic therapy decrease cancer risk in patients with osteoporotic vertebral fractures." In Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.3820.

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Reports on the topic "Osteoporotic fractures"

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Wu, Fan, Zhi-hui Huang, Bin Xu, Dawei Sang, Zhi-gang Li, and De Liang. Extrapedicular vs transpedicular percutaneous kyphoplasty for osteoporotic vertebral compression fractures. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2023. http://dx.doi.org/10.37766/inplasy2023.3.0048.

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Review question / Objective: To assess the efficacy and safety of the two approaches as a treatment for patients with OVCF. Condition being studied: Osteoporotic Vertebral Compression Fractures(OVCFs) is one of the most common health problems in the elderly population. Percutaneous kyphoplasty is a minimally invasive technique that has gained widespread recognition. Transpedicular and extrapedicular are two approaches for kyphoplasty. But over the last decade, the safety and effect of two approaches remain unclear, and there is still a lack if evaluation of their therapeutic effects. Information sources: We searched CENTRAL; MEDLINE; EMBASE; Chinese Biological Medicine Database; VIP Journals Database; Wan-fang database, CNKI; and Chinese Evidence-Based Medicine Database from the their inception to December 2020. The search terms used were: the transpedicular approach and extrapedicular approach for treating OVCF in both English and Chinese. We also searched our own files manually for relevant articles. We hand searched Chinese language journals and conference proceedings. We included dissertations and abstracts, provided they contained sufficient detail for critical evaluation.

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Mao, wei, Ai-guo LI, Fei DONG, Sheng Nan QIN, Pei liang he, guowei huang, and huan chen. Risk factors for secondary fractures to percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2021. http://dx.doi.org/10.37766/inplasy2021.4.0128.

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Li, Tong, Yiran Wang, Qiang Ran, Yang Yu, Leiming Jiang, Yin Shi, Qun Zhou, and Xiaohong Fan. Unilateral curved percutaneous vertebroplasty for osteoporotic vertebral compression fractures: A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2021. http://dx.doi.org/10.37766/inplasy2021.4.0001.

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Sun, Hai-Bo, Jian-Lin Shan, and Hai Tang. Percutaneous Vertebral Augmentation for Osteoporotic Vertebral Compression Fractures Will Increase the Number of Subsequent Fractures at Adjacent Vertebral Levels: A Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2021. http://dx.doi.org/10.37766/inplasy2021.5.0097.

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Dong, Chunke, Di Wu, Yingna Qi, Hongyu Wei, and Chungen Li. Therapeutic efficacy of third-generation percutaneous vertebral augmentation system in osteoporotic vertebral compression fractures: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0015.

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Xiang, Kemeng, Huiming Hou, and Ming Zhou. The efficacy of Cerus and Cucumis Polypeptide injection combined with Bisphosphonates on postmenopausal women with osteoporosis:A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2022. http://dx.doi.org/10.37766/inplasy2022.5.0067.

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Review question / Objective: The aim of this review is to evaluate the effectiveness of Cerus and Cucumis Polypeptide injection combined with Bisphosphonates for postmenopausal osteoporosis. Condition being studied: Postmenopausal osteoporosis (PMOP) is a disorder of bone metabolism caused by estrogen deficiency in women after menopause, which manifests clinically as pain, spinal deformities and even fragility fractures, affecting the quality of life of patients and possibly shortening their life span. Bisphosphonates are commonly used to control and delay the progression of the disease, improve the patient's symptoms and reduce the incidence of fragility fractures. However, single drugs are still lacking in controlling the progression of the disease, and the combination of drugs is the clinical priority.

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Dong, Depeng, Jiajun Huang, Dongxiang Chen, Liang Li, Zhiyong Huang, Dawei Luo, and Wenhui Zhang. Kiva augmentation technique versus balloon kyphoplasty for Osteoporotic vertebral compression fracture. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0068.

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Feng, Ningning, Jianbin Guan, Xing Yu, Wenhao Li, Tao Liu, Guozheng Jiang, Kaitan Yang, Yongdong Yang, and He Zhao. Jintiange Capsule May Have a Positive Effect in OVCF Patients with percutaneous vertebral augmentation: A Meta-Analysis of Randomized Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0038.

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Review question / Objective: We aimed to conduct a meta-analysis of the effects of JTG capsules on patients with OVCF underwent PVA surgery, focusing on clinical outcomes and drug safety. Condition being studied: This meta-analysis aims to systematic evaluation of clinical efficacy and adverse effects of JTG with PVA in the treatment of osteoporotic vertebral compression fracture (OVCF).Our current evidence suggests that JTG capsule may relieve pain in OVCF patients who underwent PVA surgery, improve functional activity, and increase BMD, particularly in patients under the age of 70, as well as increase BGP levels.However, considering the unsatisfactory quality of the included trials, more high-quality trials are needed to prove this issue.

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Wang, Qiang, Changtai Sun, Liang Zhang, Lin Wang, Quan Ji, Nan Min, and Zilong Yin. High- Vs Low-Viscosity Cement Vertebroplasty For Osteoporotic Vertebral Compression Fracture: A Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2021. http://dx.doi.org/10.37766/inplasy2021.6.0110.

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Yokota, Hiroki. Development of a Novel Synthetic Drug for Osteoporosis and Fracture Healing. Fort Belvoir, VA: Defense Technical Information Center, September 2014. http://dx.doi.org/10.21236/ada613289.

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