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Journal articles on the topic 'Otitis Media Haemophilus influenzae'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Antonelli, Patrick J., Kathleen A. Daly, Steven K. Juhn, Erik J. Veum, George L. Adams, and G. Scott Giebink. "Tobacco Smoke and Otitis Media in the Chinchilla Model." Otolaryngology–Head and Neck Surgery 111, no. 4 (1994): 513–18. http://dx.doi.org/10.1177/019459989411100421.

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To determine whether tobacco smoke contributes to the pathogenesis of acute otitis media, chinchillas were exposed to mainstream tobacco smoke or sham conditions (cigarettes not lit) In a Walton smoke exposure machine for 20-minute cycles two or three times daily. After 6 to 8 weeks of daily exposure. 12 chinchillas were nasally injected with Streptococcus pneumoniae, and 18 chinchillas were injected into both middle ears with nontypable Haemophilus Influenzae. Smoke or sham exposures were continued for 2 to 4 weeks after injection. Otitis media developed in none of the 12 nasally injected chi

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2

St. Geme, Joseph W. "The pathogenesis of nontypable Haemophilus influenzae otitis media." Vaccine 19 (December 2000): S41—S50. http://dx.doi.org/10.1016/s0264-410x(00)00277-2.

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3

DEMARIA, THOMAS F. "Animal models for nontypable Haemophilus influenzae otitis media." Pediatric Infectious Disease Journal 8, Supplement (1989): S42. http://dx.doi.org/10.1097/00006454-198901001-00016.

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4

Yamaguchi, T., T. F. DeMaria, and D. J. Lim. "Antibody Response in Experimental Haemophilus influenzae Otitis Media." Archives of Otolaryngology - Head and Neck Surgery 112, no. 5 (1986): 554–57. http://dx.doi.org/10.1001/archotol.1986.03780050078014.

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5

Murphy, Timothy F. "Vaccines for Nontypeable Haemophilus influenzae: the Future Is Now." Clinical and Vaccine Immunology 22, no. 5 (2015): 459–66. http://dx.doi.org/10.1128/cvi.00089-15.

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ABSTRACTInfections due to nontypeableHaemophilus influenzaeresult in enormous global morbidity in two clinical settings: otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD). Recurrent otitis media affects up to 20% of children and results in hearing loss, delays in speech and language development and, in developing countries, chronic suppurative otitis media. Infections in people with COPD result in clinic and emergency room visits, hospital admissions, and respiratory failure. An effective vaccine would prevent morbidity, help

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6

WALD, ELLEN R. "Haemophilus influenzae as a cause of acute otitis media." Pediatric Infectious Disease Journal 8, Supplement (1989): S31. http://dx.doi.org/10.1097/00006454-198901001-00012.

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Diamond, C., P. R. Sisson, A. M. Kearns, and H. R. Ingham. "Bacteriology of chronic otitis media with effusion." Journal of Laryngology & Otology 103, no. 4 (1989): 369–71. http://dx.doi.org/10.1017/s0022215100108989.

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AbstractSamples of middle ear effusions from 102 children with serous and mucoid otitis media were cultured for mycoplasmas and bacteria. No sample yielded mycoplasmas but bacteria were cultured from 48 (47 per cent). Organisms commonly regarded as pathogens were present in 25 samples (Haemophilus influenzae 17, Streptococcus pneumoniae four, other streptococci four). The only sample from which anaerobic bacteria were isolated was from a patient with cholesteatoma.

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8

Alzbutienė, Giedrė, Ann Hermansson, Per Cayè-Thomasen, and Vytenis Kinduris. "Tympanic membrane changes in experimental acute otitis media and myringotomy." Medicina 44, no. 4 (2008): 313. http://dx.doi.org/10.3390/medicina44040041.

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Objective. The present experimental study explored pathomorphological changes and calcium depositions in the tympanic membrane during experimental acute otitis media caused by nontypeable Haemophilus influenzae in myringotomized and nonmyringotomized ears. Material and methods. A rat model of experimental acute otitis media caused by nontypeable Haemophilus influenzae was employed. Sixteen Sprague-Dawley rats were used. Four days following middle ear inoculation, a bilateral myringotomy was performed in six randomly selected animals. Another group of 10 animals was inoculated only. On days 4,

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Babin, Emmanuel, Vincent Lemarchand, Sylvain Moreau, Marc Goullet de Rugy, André Valdazo, and Arnaud Bequignon. "Failure of antibiotic therapy in acute otitis media." Journal of Laryngology & Otology 117, no. 3 (2003): 173–76. http://dx.doi.org/10.1258/002221503321192449.

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The aim of this retrospective study was to determine the possible causes of failure of antibiotic therapy in children with acute otitis media (AOM). Thirty-nine samples of middle-ear fluid were obtained by myringotomy from 31 children suffering from AOM, unrelieved by antibiotic therapy administered for over 48 hours. The samples were analysed by the usual microbiological techniques, including cultures, tests for beta-lactamase producing strains and the determination of the minimal inhibitory concentration of penicillin for Streptococcus pneumoniae. In 14 samples, no bacterial strains were det

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10

Faden, Howard, Thomas Foels, Linda Duffy, and Jung J. Hong. "Adherence of Nontypeable Haemophilus Influenzae to Respiratory Epithelium of Otitis-Prone and Normal Children." Annals of Otology, Rhinology & Laryngology 105, no. 5 (1996): 367–70. http://dx.doi.org/10.1177/000348949610500507.

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Three hundred six children were enrolled at birth in a prospective study of otitis media and followed up for 2 years. Adherence of nontypeable Haemophilus influenzae to buccal epithelial cells was compared between otitis-prone children and age- and sex-matched normal controls at birth, 1 year, and 2 years. The mean ± SD/median percent adherence was similar for the two groups at birth (1.6 ± 2.3/1.0 versus 1.2 ± 1.4/1.0; NS) and at 2 years (1.6 ± 1.7/1.5 versus 2.1 ±2.1/1.5; NS). At 1 year of age the adherence rate for the otitis-prone group (2.4 ± 2.6/1.0) was statistically greater than that f

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11

Kosikowska, Urszula, Edyta Chwiejczak, Artur Niedzielski, Sylwia Andrzejczuk, and Anna Malm. "Haemophilus influenzae and Haemophilus parainfluenzae occurrence in the ear effusion in pediatric patients prone to recurrent respiratory tract infections (RRTI) and with otitis media with effusion (OME)." Current Issues in Pharmacy and Medical Sciences 32, no. 4 (2019): 183–88. http://dx.doi.org/10.2478/cipms-2019-0032.

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Abstract Introduction. Haemophilus influenzae and Haemophilus parainfluenzae are known as human-restricted respiratory microbiota representatives. The aim of the present paper was to assay haemophili prevalence in middle ear effusion specimens in pediatric patients with otitis media with effusion (OME). Methods. A total of 86 ear effusion specimens (from the left and right ear independently) were collected from 43 pediatric patients with OME. For comparison, 58 nasopharyngeal specimens were taken from 58 pediatric patients prone to recurrent respiratory tract infections (RRTI). Isolation and i

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12

Green, Bruce A., Elizabeth Baranyi, Thomas J. Reilly, Arnold L. Smith, and Gary W. Zlotnick. "Certain Site-Directed, Nonenzymatically Active Mutants of the Haemophilus influenzae P4 Lipoprotein Are Able To Elicit Bactericidal Antibodies." Infection and Immunity 73, no. 7 (2005): 4454–57. http://dx.doi.org/10.1128/iai.73.7.4454-4457.2005.

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ABSTRACT The Haemophilus influenzae P4 lipoprotein (hel) is a potential component of a nontypeable H. influenzae otitis media vaccine. Since P4 is known to be an enzyme, nonenzymatically active forms of recombinant P4 are required. After site-directed mutagenesis of the hel gene, three of the mutated proteins were shown to be vaccine candidates.

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Loosmore, Sheena M., Yan-ping Yang, Ray Oomen, Jean M. Shortreed, Debbie C. Coleman, and Michel H. Klein. "The Haemophilus influenzae HtrA Protein Is a Protective Antigen." Infection and Immunity 66, no. 3 (1998): 899–906. http://dx.doi.org/10.1128/iai.66.3.899-906.1998.

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ABSTRACT The htrA gene from two strains of nontypeableHaemophilus influenzae has been cloned and sequenced, and the encoded approximately 46-kDa HtrA proteins were found to be highly conserved. H. influenzae HtrA has approximately 55% identity with the Escherichia coli and Salmonella typhimurium HtrA stress response proteins, and expression of theH. influenzae htrA gene was inducible by high temperature. Recombinant HtrA (rHtrA) was expressed from E. coli, and the purified protein was found to have serine protease activity. rHtrA was found to be very immunogenic and partially protective in bot

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14

Gönüllü, Erdem, Nesrin Özkan, Ahmet Soysal, et al. "Nontypeable Haemophilus influenzae Otitis Media: Mastoiditis and Meningitis Complicated with Central Venous Thrombosis in an Immunocompetent Child." Case Reports in Infectious Diseases 2021 (March 12, 2021): 1–5. http://dx.doi.org/10.1155/2021/8845200.

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Implementation of the Haemophilus influenzae type B (Hib) conjugate vaccine brought about a reduction in the number of cases and morbidity from type B but an increase in nontypeable strain infections. Nontypeable Haemophilus influenzae (NTHi) commonly colonizes children’s upper respiratory tract and causes otitis media, sinusitis, and bronchitis. Invasive NTHi diseases, such as meningitis and septicemia, have rarely been reported. Herein, we discuss a previously healthy, fully immunized 3-year-old girl presented with otitis media and mastoiditis leading to meningitis caused by NTHi complicated

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15

Harabuchi, Y., H. Faden, N. Yamanaka, L. Duffy, J. Wolf, and D. Krystofik. "Nasopharyngeal Colonization With Nontypeable Haemophilus Influenzae And Recurrent Otitis Media." Journal of Infectious Diseases 170, no. 4 (1994): 862–66. http://dx.doi.org/10.1093/infdis/170.4.862.

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16

Krekorian, Terry D., Elizabeth M. Keithley, Joshua Fierer, and Jeffrey P. Harris. "Type B Haemophilus influenzae???Induced Otitis Media in the Mouse." Laryngoscope 101, no. 6 (1991): 648???656. http://dx.doi.org/10.1288/00005537-199106000-00013.

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17

Van Hoecke, Helen, Ann-Sophie De Paepe, Edward Lambert, et al. "Haemophilus influenzae biofilm formation in chronic otitis media with effusion." European Archives of Oto-Rhino-Laryngology 273, no. 11 (2016): 3553–60. http://dx.doi.org/10.1007/s00405-016-3958-9.

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18

Juliao, Patricia C., Carl F. Marrs, Jingping Xie, and Janet R. Gilsdorf. "Histidine Auxotrophy in Commensal and Disease-Causing Nontypeable Haemophilus influenzae." Journal of Bacteriology 189, no. 14 (2007): 4994–5001. http://dx.doi.org/10.1128/jb.00146-07.

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ABSTRACT Histidine biosynthesis is one of the best studied metabolic pathways in bacteria. Although this pathway is thought to be highly conserved within and between bacterial species, a previous study identified a genetic region within the histidine operon (his) of nontypeable strains of Haemophilus influenzae (NTHI) that was more prevalent among otitis media strains than among throat commensal NTHI strains. In the present study, we further characterized this region and showed that genes in the complete his operon (hisG, -D, -C, -NB, -H, -A, -F, and -IE) are >99% conserved among four fully

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19

Foxwell, A. Ruth, Jennelle M. Kyd, and Allan W. Cripps. "Nontypeable Haemophilus influenzae: Pathogenesis and Prevention." Microbiology and Molecular Biology Reviews 62, no. 2 (1998): 294–308. http://dx.doi.org/10.1128/mmbr.62.2.294-308.1998.

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SUMMARY In this paper, we describe the ability of nontypeable Haemophilus influenzae (NTHi) to coexist with the human host and the devastating results associated with disruption of the delicate state of balanced pathogenesis, resulting in both acute and chronic respiratory tract infections. It has been seen that the strains of NTHi causing disease show a marked genetic and phenotypic diversity but that changes in the lipooligosaccharide (LOS) and protein size and antigenicity in chronically infected individuals indicate that individual strains of NTHi can remain and adapt themselves to avoid e

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20

Munson, Robert S., Alistair Harrison, Allison Gillaspy, et al. "Partial Analysis of the Genomes of Two Nontypeable Haemophilus influenzae Otitis Media Isolates." Infection and Immunity 72, no. 5 (2004): 3002–10. http://dx.doi.org/10.1128/iai.72.5.3002-3010.2004.

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ABSTRACT In 1995, The Institute for Genomic Research completed the genomic sequence of a rough derivative of Haemophilus influenzae serotype d, strain KW20. This sequence, though extremely useful in understanding the basic biology of H. influenzae, has yet to provide significant insight into our understanding of disease caused by nontypeable H. influenzae (NTHI), because serotype d strains are not generally pathogens. In contrast, NTHI strains are frequently mucosal pathogens and are the primary pathogens of chronic otitis media as well as a significant cause of acute otitis media in children.

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Harrison, Alistair, David W. Dyer, Allison Gillaspy, et al. "Genomic Sequence of an Otitis Media Isolate of Nontypeable Haemophilus influenzae: Comparative Study with H. influenzae Serotype d, Strain KW20." Journal of Bacteriology 187, no. 13 (2005): 4627–36. http://dx.doi.org/10.1128/jb.187.13.4627-4636.2005.

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ABSTRACT In 1995, the Institute for Genomic Research completed the genome sequence of a rough derivative of Haemophilus influenzae serotype d, strain KW20. Although extremely useful in understanding the basic biology of H. influenzae, these data have not provided significant insight into disease caused by nontypeable H. influenzae, as serotype d strains are not pathogens. In contrast, strains of nontypeable H. influenzae are the primary pathogens of chronic and recurrent otitis media in children. In addition, these organisms have an important role in acute otitis media in children as well as o

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22

Kawana, Masahiro. "Early Inflammatory Changes of the Haemophilus influenzae-Induced Experimental Otitis Media." Auris Nasus Larynx 22, no. 2 (1995): 80–85. http://dx.doi.org/10.1016/s0385-8146(12)80104-0.

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23

Faden, H., L. Brodsky, J. Bernstein, et al. "Otitis media in children: local immune response to nontypeable Haemophilus influenzae." Infection and Immunity 57, no. 11 (1989): 3555–59. http://dx.doi.org/10.1128/iai.57.11.3555-3559.1989.

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24

Barenkamp, S. J. "Protection by serum antibodies in experimental nontypable Haemophilus influenzae otitis media." Infection and Immunity 52, no. 2 (1986): 572–78. http://dx.doi.org/10.1128/iai.52.2.572-578.1986.

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Yang, Yan-ping, Sheena M. Loosmore, Brian J. Underdown, and Michel H. Klein. "Nasopharyngeal Colonization with Nontypeable Haemophilus influenzae in Chinchillas." Infection and Immunity 66, no. 5 (1998): 1973–80. http://dx.doi.org/10.1128/iai.66.5.1973-1980.1998.

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ABSTRACT Colonization of the nasopharynx by a middle ear pathogen is the first step in the development of otitis media in humans. The establishment of an animal model of nasopharyngeal colonization would therefore be of great utility in assessing the potential protective ability of candidate vaccine antigens (especially adhesins) against otitis media. A chinchilla nasopharyngeal colonization model for nontypeable Haemophilus influenzae (NTHI) was developed with antibiotic-resistant strains. This model does not require coinfection with a virus. There was no significant difference in the efficie

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Bernstein, Joel M., Michael Belmont, Howard S. Faden, Diane Dryja, Frank Scannapieco, and Judy Wolf. "Interference of Nontypeable Haemophilus Influenzae and Moraxella Catarrhalis by Streptococcus Oralis in Adenoid Organ Culture: A Possible Strategy for the Treatment of the Otitis-Prone Child." Annals of Otology, Rhinology & Laryngology 111, no. 8 (2002): 696–700. http://dx.doi.org/10.1177/000348940211100807.

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The role of viridans group streptococci (Streptococcus oralis) in the prevention of colonization with nontypeable Haemophilus influenzae and Moraxella catarrhalis was investigated in an adenoid organ culture system. The adenoids from 100 patients who were undergoing adenoidectomy for either hypertrophy or recurrent otitis media were used. Streptococcus oralis Parker uniformly inhibited colonization with nontypeable H influenzae or M catarrhalis over a 24-hour period of incubation in adenoid organ culture. Streptococcus oralis Booth, a noninhibitory strain, did not significantly reduce coloniza

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Allen, Simon, Anthony Zaleski, Jason W. Johnston, Bradford W. Gibson, and Michael A. Apicella. "Novel Sialic Acid Transporter of Haemophilus influenzae." Infection and Immunity 73, no. 9 (2005): 5291–300. http://dx.doi.org/10.1128/iai.73.9.5291-5300.2005.

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ABSTRACT Nontypeable Haemophilus influenzae is an opportunistic pathogen and a common cause of otitis media in children and of chronic bronchitis and pneumonia in patients with chronic obstructive pulmonary disease. The lipooligosaccharides, a major component of the outer membrane of H. influenzae, play an important role in microbial virulence and pathogenicity. N-Acetylneuraminic acid (sialic acid) can be incorporated into the lipooligosaccharides as a terminal nonreducing sugar. Although much of the pathway of sialic acid incorporation into lipooligosaccharides is understood, the transporter

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Sugita, Rinya, Yutaka Fujimaki, and Koichi Deguchi. "Bacteriological features and chemotherapy of adult acute purulent otitis media." Journal of Laryngology & Otology 99, no. 7 (1985): 629–35. http://dx.doi.org/10.1017/s0022215100097395.

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Abstract Eighty-eight patients from 16 to 79 years old, with acute purulent otitis media, were bacteriologically examined at the Otorhinolaryngology Department of a primary care hospital in Tokyo from July 1979 to May 1983. Fifty-six patients underwent paracentesis, and 32 patients exhibited otorrhea due to previous spontaneous perforation of the tympanic membrane.Bacteriologic cultures revealed the presence of Streptococcus pneumoniae (62.5 per cent), including S. pneumoniae Type III (28.1 per cent), Haemophilus influenzae (10.5 per cent), Staphylococcus aureus (11.5 per cent), and Streptococ

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Smith-Vaughan, Heidi, Robyn Marsh, and Amanda Leach. "Otitis media: an ongoing microbial challenge." Microbiology Australia 30, no. 5 (2009): 181. http://dx.doi.org/10.1071/ma09181.

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Young Australian Indigenous children in remote Northern Territory communities suffer excessively high rates of otitis media (OM) and remain at high risk of suppurative complications with poor audiological and educational sequelae. Efforts to effectively treat this condition are confounded by the frequent failure of standard antibiotic treatment regimens, despite good therapeutic compliance and susceptibility of the major pathogens. OM has a complex, polymicrobial aetiology. Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are the recognised major pathogens; however, b

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Tristram, Stephen, Michael R. Jacobs, and Peter C. Appelbaum. "Antimicrobial Resistance in Haemophilus influenzae." Clinical Microbiology Reviews 20, no. 2 (2007): 368–89. http://dx.doi.org/10.1128/cmr.00040-06.

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SUMMARY Haemophilus influenzae is a major community-acquired pathogen causing significant morbidity and mortality worldwide. Meningitis and bacteremia due to type b strains occur in areas where the protein-conjugated type b vaccine is not in use, whereas nontypeable strains are major causes of otitis media, sinusitis, acute exacerbations of chronic bronchitis, and pneumonia. Antibiotic resistance in this organism is more diverse and widespread than is commonly appreciated. Intrinsic efflux resistance mechanisms limit the activity of the macrolides, azalides, and ketolides. β-Lactamase producti

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Sørensen, Christian Hjort, and Kirsten Brygge. "Mucosal Immunity and Bacteriology of the Eustachian Tube." Ear, Nose & Throat Journal 77, no. 9 (1998): 748–61. http://dx.doi.org/10.1177/014556139807700912.

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The pathogenesis of otitis media is a multifaceted process that is not completely understood. Eustachian tube dysfunction plays a central but uncertain role, as do viral and bacterial microorganisms. Of the latter, the three most important are Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. This article reviews the various mechanisms of infection and the immune system's response to them.

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Mason, Kevin M., Robert S. Munson, and Lauren O. Bakaletz. "Nontypeable Haemophilus influenzae Gene Expression Induced In Vivo in a Chinchilla Model of Otitis Media." Infection and Immunity 71, no. 6 (2003): 3454–62. http://dx.doi.org/10.1128/iai.71.6.3454-3462.2003.

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ABSTRACT The gram-negative bacterium nontypeable Haemophilus influenzae (NTHI) is the predominant pathogen in chronic otitis media with effusion and, with Streptococcus pneumoniae and Moraxella catarrhalis, is a causative agent of acute otitis media. To identify potential virulence determinants, bacterial gene expression was monitored by differential fluorescence induction during early disease progression in one specific anatomical niche of a chinchilla model of NTHI-induced otitis media. Genomic DNA fragments from NTHI strain 86-028NP were cloned upstream of the promoterless gfpmut3 gene. NTH

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Stull, Terrence, Paul Whitby, Daniel Morton, Huda Mussa, and Lucia Mirea. "15. A Novel Approach to Bacterial Vaccines: Haemophilus influenzae as a Paradigm." Open Forum Infectious Diseases 7, Supplement_1 (2020): S30. http://dx.doi.org/10.1093/ofid/ofaa439.060.

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Abstract Background The H. influenzae type b vaccines target the type b capsule and therefore have no impact on the nontypable (unencapsulated) H. influenzae (NTHi). NTHi has become the most common cause of otitis media and is the most common isolate from patients with exacerbations of Chronic Obstructive Pulmonary Disease (COPD). Therefore, NTHi is an appropriate target for vaccine development. Methods To characterize potential vaccine targets, the core outer proteins of NTHi present in the available sequenced genomes were identified through genomic bioinformatics. The structures of the outer

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Sillanpää, Saara, Sami Oikarinen, Markku Sipilä, et al. "Moraxella catarrhalis Might Be More Common than Expected in Acute Otitis Media in Young Finnish Children." Journal of Clinical Microbiology 54, no. 9 (2016): 2373–79. http://dx.doi.org/10.1128/jcm.01146-16.

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According to studies based on bacterial cultures of middle ear fluids,Streptococcus pneumoniae,Haemophilus influenzae, andMoraxella catarrhalishave been the most common pathogens in acute otitis media. However, bacterial culture can be affected by reduced viability or suboptimal growth of bacteria. PCR detects bacterial DNA from samples with greater sensitivity than culture. In the present study, we analyzed the middle ear pathogens with both conventional culture and semiquantitative real-time PCR in 90 middle ear fluid samples obtained from children aged 5 to 42 months during acute otitis med

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Novotny, Laura A., Kevin M. Mason, and Lauren O. Bakaletz. "Development of a Chinchilla Model To Allow Direct, Continuous, Biophotonic Imaging of Bioluminescent Nontypeable Haemophilus influenzae during Experimental Otitis Media." Infection and Immunity 73, no. 1 (2005): 609–11. http://dx.doi.org/10.1128/iai.73.1.609-611.2005.

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ABSTRACT We transformed a nontypeable Haemophilus influenzae clinical isolate with a plasmid containing the luxCDABE operon driven by the H. influenzae outer membrane protein P2 promoter. Herein, we demonstrate the ability to detect bioluminescence and to monitor infection within the nasopharynges, eustachian tubes, and middle ears of chinchillas after intranasal and transbullar challenges.

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Dunne, Michael W., Chandra Khurana, Adriano Arguedas Mohs, et al. "Efficacy of Single-Dose Azithromycin in Treatment of Acute Otitis Media in Children after a Baseline Tympanocentesis." Antimicrobial Agents and Chemotherapy 47, no. 8 (2003): 2663–65. http://dx.doi.org/10.1128/aac.47.8.2663-2665.2003.

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ABSTRACT Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.

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Khan, M. Nadeem, Dabin Ren, Ravinder Kaur, Saleem Basha, Robert Zagursky, and Michael E. Pichichero. "Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae." Expert Review of Vaccines 15, no. 7 (2016): 863–78. http://dx.doi.org/10.1586/14760584.2016.1156539.

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Fulghum, Robert S., Ronald P. Hoogmoed, and Jack E. Brinn. "Longitudinal studies of experimental otitis media with Haemophilus influenzae in the gerbil." International Journal of Pediatric Otorhinolaryngology 9, no. 2 (1985): 101–14. http://dx.doi.org/10.1016/s0165-5876(85)80010-0.

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BARENKAMP, STEPHEN J., and FRANK F. BODOR. "Development of serum bactericidal activity following nontypable Haemophilus influenzae acute otitis media." Pediatric Infectious Disease Journal 9, no. 5 (1990): 333–38. http://dx.doi.org/10.1097/00006454-199005000-00006.

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STENFORS, LARS-ERIC, and SIMO RÄISÄNEN. "Occurrence of Streptococcus pneumoniae and Haemophilus influenzae in otitis media with effusion." Clinical Otolaryngology 17, no. 3 (1992): 195–99. http://dx.doi.org/10.1111/j.1365-2273.1992.tb01825.x.

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Stenfors, L. E., and S. Räisänen. "OCCURRENCE OF STREPTOCOCCUS PNEUMONIAE AND HAEMOPHILUS INFLUENZAE IN OTITIS MEDIA WITH EFFUSION." Pediatric Infectious Disease Journal 12, no. 2 (1993): 175. http://dx.doi.org/10.1097/00006454-199302000-00028.

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Melhus, Åsa, Ann Hermansson, Mustafa Akkoyunlu, Arne Forsgren, and Karin Prellner. "Experimental recurrent otitis media induced by Haemophilus influenzae: Protection and serum antibodies." American Journal of Otolaryngology 16, no. 6 (1995): 383–90. http://dx.doi.org/10.1016/0196-0709(95)90075-6.

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Nonomura, N., Y. Nakano, Y. Satoh, O. Fujioka, H. Niijima, and M. Fujita. "Otitis media with effusion following inoculation of Haemophilus influenzae type b endotoxin." Archives of Oto-Rhino-Laryngology 243, no. 1 (1986): 31–35. http://dx.doi.org/10.1007/bf00457904.

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Moriyama, Satomi, Muneki Hotomi, Jun Shimada, Dewan S. Billal, Keiji Fujihara, and Noboru Yamanaka. "Formation of biofilm by Haemophilus influenzae isolated from pediatric intractable otitis media." Auris Nasus Larynx 36, no. 5 (2009): 525–31. http://dx.doi.org/10.1016/j.anl.2008.10.010.

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Jacobs, Michael R., Ron Dagan, Peter C. Appelbaum, and Daniel J. Burch. "Prevalence of Antimicrobial-Resistant Pathogens in Middle Ear Fluid: Multinational Study of 917 Children with Acute Otitis Media." Antimicrobial Agents and Chemotherapy 42, no. 3 (1998): 589–95. http://dx.doi.org/10.1128/aac.42.3.589.

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ABSTRACT The management of acute otitis media is complicated by the emergence of resistance to β-lactam and other antibiotics among common pathogens. We conducted a large, international study of infants and children with acute otitis media to identify pathogens and susceptibility patterns. During the winter of 1994 to 1995, middle ear fluid samples were collected from 917 patients with acute otitis media in Bulgaria, the Czech Republic, Hungary, Romania, Slovakia, Israel, and the United States. A single reference laboratory performed in vitro susceptibility testing. Pathogens were isolated fro

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Yadav, Lal Kishor, Prakash Bahadur Thapa, and Jayendra Pradhananga. "Otogenic Intracranial Complications in Bir Hospital; an Eight Years Retrospective Review." Nepalese Journal of ENT Head and Neck Surgery 6, no. 1 (2018): 25–28. http://dx.doi.org/10.3126/njenthns.v6i1.19441.

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Objectives: To review our experiences on intracranial complications secondary to otitis media and to compare the results with other studies.Material and Methods: A retrospective chart review of all patients with intracranial complications secondary to otitis media over eight years period in Bir hospital was done. Clinical presentation, radiological findings, microbiology, surgical management and antibiotics used were studied.Results: Forty eight cases were included in this study of which 23 had meningitis, 15 had brain abscess, 7 had lateral sinus thrombosis and 3 had petrositis. 37 of these w

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Moxon, E. Richard. "Bacterial variation, virulence and vaccines." Microbiology 155, no. 4 (2009): 997–1003. http://dx.doi.org/10.1099/mic.0.024877-0.

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Research into Haemophilus influenzae, a commensal and pathogen of humans, has resulted in major scientific contributions to biology. The first endonucleases (restriction enzymes), which paved the way for the new genetics, and the DNA used to obtain the first complete genome sequence of a free-living organism were obtained from H. influenzae. Prevention of invasive bacterial infections of infants, such as meningitis, has been achieved using a novel class of vaccines, of which the glycoconjugates of H. influenzae were the first to be licensed. Originally fallaciously proposed to be the aetiologi

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Daines, Dayle A., Leah A. Cohn, Hannah N. Coleman, Kwang Sik Kim, and Arnold L. Smith. "Haemophilus influenzae Rd KW20 has virulence properties." Journal of Medical Microbiology 52, no. 4 (2003): 277–82. http://dx.doi.org/10.1099/jmm.0.05025-0.

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Haemophilus influenzae is a human-adapted commensal and pathogen that can cause mucosal infections such as sinusitis, otitis media and bronchitis. Certain strains also cause bacteraemia and meningitis. Clinical isolates are genetically heterogeneous and are often recalcitrant to standard genetic manipulation. H. influenzae strain Rd KW20 has traditionally been considered avirulent, since it does not survive in the bloodstream of animals, is readily killed by normal adult human sera and cannot colonize the nasopharynx of infant rats. The purpose of this study was to determine whether Rd KW20 co

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Folino, Francesco, Luca Ruggiero, Pasquale Capaccio, et al. "Upper Respiratory Tract Microbiome and Otitis Media Intertalk: Lessons from the Literature." Journal of Clinical Medicine 9, no. 9 (2020): 2845. http://dx.doi.org/10.3390/jcm9092845.

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Otitis media (OM) is one of the most common diseases occurring during childhood. Microbiological investigations concerning this topic have been primarily focused on the four classical otopathogens (Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes) mainly because most of the studies have been conducted with culture-dependent methods. In recent years, the introduction of culture-independent techniques has allowed high-throughput investigation of entire bacterial communities, leading to a better comprehension of the role of resident flora in healt

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Harrison, Alistair, William C. Ray, Beth D. Baker, David W. Armbruster, Lauren O. Bakaletz, and Robert S. Munson. "The OxyR Regulon in Nontypeable Haemophilus influenzae." Journal of Bacteriology 189, no. 3 (2006): 1004–12. http://dx.doi.org/10.1128/jb.01040-06.

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ABSTRACT Nontypeable Haemophilus influenzae (NTHi) is a gram-negative bacterium and a common commensal organism of the upper respiratory tract in humans. NTHi causes a number of diseases, including otitis media, sinusitis, conjunctivitis, exacerbations of chronic obstructive pulmonary disease, and bronchitis. During the course of colonization and infection, NTHi must withstand oxidative stress generated by insult due to multiple reactive oxygen species produced endogenously by other copathogens and by host cells. Using an NTHi-specific microarray containing oligonucleotides representing the 18

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