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Dissertations / Theses on the topic 'Outer hair cells'

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Published: 4 June 2021

Last updated: 7 February 2022

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1

Jagger, Daniel James. "Modulation of ion channels in outer hair cells from the mammalian cochlea." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336876.

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2

Richmond, Sarah Jane. "A study of in situ outer hair cells from the adult mammalian cochlea." Thesis, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313691.

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3

Gale, Jonathan Edward. "Mechanosensitivity of the basolateral membrane of outer hair cells from the mammalian cochlea." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240651.

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4

Liang, Guihua. "K⁺ channels in the inner ear : electrophysiological and molecular studies /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7349-971-4/.

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5

Abou, Dakka Milad. "Linear oscillatory dynamics of flexoelectric membranes embedded in viscoelastic media with applications to outer hair cells." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114535.

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Membrane flexoelectricity is an electromechanical coupling effect between the membrane average curvature and macroscopic electric polarization. Flexolelectricity is a biological actuation mechanism involved in the functioning of hearing. This thesis uses theory and simulation to develop a fundamental understanding of flexolectricity of relevance to hearing processes by integrating membrane elasticity and flexolectricity with viscoelastic processes. Flexoelectric actuation uses an imposed electric field to create membrane bending. In this thesis we model the small amplitude oscillatory dy

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6

Spreadbury, Ian Clive. "Single channel recordings form the BK channels of outer hair cells of the guinea pig cochlea." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322611.

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7

Roberts, Terri Patricia. "Developmental failure in cochlear hair cells from mouse models of Usher syndrome and the identification of an acid sensitive ionic current in Inner and Outer hair cells." Thesis, University of Sussex, 2013. http://sro.sussex.ac.uk/id/eprint/46460/.

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Inner hair cells (IHCs) are the primary sensory receptors of the mammalian cochlea. I employed the whole-cell patch-clamp technique to study voltage responses and ionic currents of IHCs in mice bearing mutations in hair bundle proteins. These mutations, all associated with Usher syndrome, lead to structural and functional defects of the mechanosensory hair bundle. I observed developmental failure in the electrical properties of IHCs from these mutants: a continuation of neonatal spiking instead of the graded receptor potentials seen in control adult IHCs. Voltage-clamp recordings revealed the

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8

Wilson, Caroline Lesley. "The hair follicle : studies of the outer root sheath in health and disease, and a possible role for the bulge." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309741.

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9

Leitner, Michael [Verfasser], and Dominik [Akademischer Betreuer] Oliver. "Molecular Properties and Pathophysiological Relevance of the Predominant K+ Conductance in Cochlear Outer Hair Cells / Michael Leitner. Betreuer: Dominik Oliver." Marburg : Philipps-Universität Marburg, 2012. http://d-nb.info/1027183662/34.

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10

Wright, Daniel. "Anatomical and electrophysiological investigation of the distribution of acetylcholine receptors in the post synaptic membrane of mammalian cochlear outer hair cells." Thesis, Keele University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250420.

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11

Shiraishi, Hisako. "Design of an Analog VLSI Cochlea." University of Sydney. Electrical and Information Engineering, 2003. http://hdl.handle.net/2123/556.

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The cochlea is an organ which extracts frequency information from the input sound wave. It also produces nerve signals, which are further analysed by the brain and ultimately lead to perception of the sound. An existing model of the cochlea by Fragni`ere is first analysed by simulation. This passive model is found to have the properties that the living cochlea does in terms of the frequency response. An analog VLSI circuit implementation of this cochlear model in CMOS weak inversion is proposed, using log-domain filters in current domain. It is fabricated on a chip and a measurement of a bas

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12

Syam, Diana. "Immobilizing Mutation in an Unconventional Myosin15a Affects not only the Structure of Mechanosensory Stereocilia in the Inner Ear Hair Cells but also their Ionic Conductances." UKnowledge, 2014. http://uknowledge.uky.edu/medsci_etds/2.

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In the inner and outer hair cells (OHCs) of the inner ear, an unconventional myosin 15a localizes at the tips of mechanosensory stereocilia and plays an important role in forming and maintaining their normal structure. A missense mutation makes the motor domain of myosin 15a dysfunctional and is responsible for the congenital deafness DFNB3 in humans and deafness and vestibular defects in Shaker-2 (Sh2) mouse model. All hair cells of homozygous Shaker-2 mice (Myo15sh2/sh2) have abnormally short stereocilia, but, only stereocilia of Myo15sh2/sh2OHCs start to degenerate after the first few days

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13

Murugasu, Euan. "In-vivo measurements of basilar membrane displacement in the basal turn of the guinea pig cochlea : evidence for the role of outer hair cells in active cochlear mechanics." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318941.

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14

O'Beirne, Greg A. "Mathematical modelling and electrophysiological monitoring of the regulation of cochlear amplification." University of Western Australia. School of Biomedical and Chemical Sciences, 2005. http://theses.library.uwa.edu.au/adt-WU2006.0115.

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[Truncated abstract] The cochlea presumably possesses a number of regulatory mechanisms to maintain cochlear sensitivity in the face of disturbances to its function. Evidence for such mechanisms can be found in the time-course of the recovery of CAP thresholds during experimental manipulations, and in observations of slow oscillations in cochlear micromechanics following exposure to low-frequency tones (the “bounce phenomenon”) and other perturbations. To increase our understanding of these oscillatory processes within the cochlea, and OHCs in particular, investigations into cochlear regulatio

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15

Lu, Timothy K. (Timothy Kuan-Ta) 1981. "A feedback analysis of outer hair cell dynamics." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29677.

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Thesis (M.Eng. and S.B.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.<br>Includes bibliographical references (leaves 144-146).<br>Outer hair cells (OHCs) generate active forces in the mammalian cochlea. Acting as cochlear amplifiers, OHCs can counteract viscous drag, generating high gain at characteristic frequencies and allowing for the sharp frequency selectivity and sensitivity observed in mammals. Excitatory displacement of the basilar membrane causes depolarization of OHC membrane potentials which results in contraction. The motor pro

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16

Körbes, Daiane. "TOXICIDADE DE AGROTÓXICO ORGANOFOSFORADO NO SISTEMA AUDITIVO PERIFÉRICO DE COBAIAS: ESTUDO ANATÔMICO E FUNCIONAL." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/6461.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The organophosphate pesticides are widely used in agriculture, and the widespread application of these agents, without the appropriate use of bio-security measures, has contributed to environmental degradation and the increased incidence of occupational poisoning, becoming one of the main public health problems in rural areas. Studies show that the ototoxic agents, in addition to the peripheral vestibular and auditory systems compromise, also impair central auditory pathways. Among the major toxic agents that can lead to hearing lo

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17

Muallem, Daniella. "An anion transporter theory of the outer hair cell motor protein." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444859/.

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This thesis addresses the mechanism of electromotility in outer hair cells (OHCs) of the mammalian cochlea. Prestin, a protein densely packed in the lateral membrane is assumed to drive electromotility. A current hypothesis is that prestin is an incomplete transporter, shuttling chloride across the membrane without allowing it to dissociate at the extracellular surface. In this thesis kinetic models are formulated to show that this hypothesis cannot reproduce the previously published experimental data from electrical recordings. However an alternative model of prestin as an anion exchanger (mo

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18

Souchal, Marion. "Surdités cachées ; atteinte des cellules sensorielles cochléaires ou du nerf auditif ?" Thesis, Université Clermont Auvergne‎ (2017-2020), 2017. http://www.theses.fr/2017CLFAS003/document.

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Les surdités neurosensorielles sont classiquement décrites par une élévation des seuils auditifs généralement corrélée à une dégénérescence des cellules ciliées externes (CCE). Toutefois, des travaux récents sur des modèles animaux ont montré qu’un audiogramme normal pouvait être associé à des atteintes auditives périphériques. Ce travail de thèse a contribué à mieux caractériser chez des modèles murins, ces déficiences supraliminaires cachées liées d’une part, à des altérations des CCE et d’autre part, à la dégénérescence de certaines fibres nerveuses auditives. Dans la première partie de cet

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19

Jiang, Beibei. "A biophysical model of the role of the outer hair cell in cochlear nonlinearity." Thesis, University of Plymouth, 2010. http://hdl.handle.net/10026.1/2235.

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It has been observed that the response characteristics of the basilar membrane in normal living cochleae are both frequency and level-sensitive (Robles & Ruggero 2001). The quality factor of the tuning curve is large at low sound levels and decreases as the sound level increases, and the peak of the tuning curve moves towards lower frequencies as the sound level increases. The current study proposes a nonlinear cochlear model that responds adaptively to the incoming sounds via feedback control arising from the mechanical attributes of the cochlear partition. These attributes are dependent

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20

Bell, James Andrew, and andrew bell@anu edu au. "The Underwater Piano: A Resonance Theory of Cochlear Mechanics." The Australian National University. Research School of Biological Sciences, 2006. http://thesis.anu.edu.au./public/adt-ANU20080706.141018.

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This thesis takes a fresh approach to cochlear mechanics. Over the last quarter of a century, we have learnt that the cochlea is active and highly tuned, observations suggesting that something may be resonating. Rather than accepting the standard traveling wave interpretation, here I investigate whether a resonance theory of some kind can be applied to this remarkable behaviour.¶ A historical survey of resonance theories is first conducted, and advantages and drawbacks examined. A corresponding look at the traveling wave theory includes a listing of its short-comings.¶ A new model of the coc

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21

Battaglia, Alex. "Ras activation contributes to outer hair cell apoptosis in the basal turn of the cochlea after cisplatin and gentamicin exposure /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3064454.

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22

Freeman, Jessica. "Short-term effects of simultaneous cardiovascular workout and personal music device use on the otoacoustic emissions of young adults." Diss., University of Pretoria, 2014. http://hdl.handle.net/2263/46259.

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Recent advances in the field of audiology have indicated that there has been a growing concern regarding the potential damage to the hearing mechanism induced by recreational noise exposure from personal music devices (PMD). Regular PMD use may have a long-term damaging effect on the outer- and inner hair cells of the cochlea which may result in a progressive hearing loss. As PMDs have advanced to a stage where the memory of the devices are able to contain hours of listening content, the environments where these devices are being used are rapidly expanding. Many young adults tend to use their

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23

Harrison, Ryan T. "Effect of Changes to the Circadian Rhythm on Susceptibility to Noise- and Drug-Induced Hearing Losses." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574719906038686.

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24

Gilbert, Benjamin Lawrence. "ACF7 DEFICIENCY DOES NOT IMPAIR AUDITORY HAIR CELL DEVELOPMENT OR HEARING FUNCTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1619801135718899.

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25

Nam, Hui S. Ph D. (Hui Sok) Massachusetts Institute of Technology. "Low-frequency bias-tone effects on auditory-nerve responses to clicks and tones : investigating multiple outer-hair-cell actions on auditory-nerve firing." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/68455.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2011.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Active motility in outer hair cells (OHCs) amplifies basilar-membrane (BM) and auditory-nerve (AN) responses to low-level sounds. The recent finding that medial olivocochlear (MOC) efferents (which innervate OHCs) inhibit AN initial peak (ANIP) responses from mid-to-high-level clicks, but do not inhibit initial BM responses, suggests a coupling of OHC motility to inner-hair-cell (IHC) stereocilia that is not through the BM. The main

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26

Ferrence, Kimberly Diane. "Studying the effects of changing experimental parameters on the medial olivocochlear efferent fibers and outer hair cell activity by measurement of distortion product otoacoustic emissions." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0015383.

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27

Fleischer, Mario. "Mehrfeldmodellierung und Simulation der äußeren Haarsinneszelle der Cochlea." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-100717.

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Das Innenohr des Säugetieres ist ein hochspezialisiertes sensorisches System, das durch ein komplexes mechanisches Verhalten gekennzeichnet ist. Neben der komplizierten Morphometrie und Geometrie kommen auch dem richtungsabhängigen Materialverhalten eine wesentliche Bedeutung zu. Es zeigt sich, daß im Cortischen Organ mit der äußeren Haarsinneszelle ein Zelltyp vorliegt, der durch seine physikalischen Eigenschaften das Gesamtverhalten des Innenohres maßgeblich beeinflußt. Wie jede tierische Zelle weist die äußere Haarsinneszelle als biomechanisches System eine heterogene Mikrostruktur auf. Vom

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28

Li, Zhiwei. "Membrane tether formation from outer hair cells with optical tweezers." Thesis, 2002. http://hdl.handle.net/1911/17521.

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The mechanical properties of the outer hair cells (OHCs) lateral wall are essential to elucidate the mechanism of OHC electromotility. Optical tweezers were used to characterize the mechanical properties of OHC plasma membrane (PM) by pulling tethers. A greater force was required for tether formations from OHC lateral wall (499 pN +/- 152) than from OHC basal end (142 pN +/- 49), consistent with the presence of a more extensive cytoskeleton support beneath the PM at the lateral wall. The apparent PM stiffness, which was estimated by measuring tether force at different tether length, was 3.71 p

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29

HUNG, CHUI CHEN, and 洪垂瑱. "Effects of L-Arginine and Taicatoxin on the Motility of Outer Hair Cells." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/63186034795561436164.

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碩士<br>中山醫學大學<br>醫學研究所<br>91<br>Abstract The effect of L-arginine on the mammalian cochlear outer hair cell was studied in this experiment. L-arginine but not D-arginine or other amino acids (L-aspartate or L-glutamine) induced length increases of guinea pig outer hair cell. Similarity, a membrane permeable cyclic GMP analog, 8-(-4- chloro- phenylthio) guanosine 3’，5’-cyclic monophosphate (pCPT -cGMP) or 8-bromo-guanosine 3’，5’-cyclic monopho- sphate induced length increases of guinea pig outer hair cells. These length increases induced by L-arginine can be attenuated by a 30 min pre

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30

Stauffer, Eric Alan. "Mechanotransduction and adaptation in mammalian vestibular and auditory hair cells." 2008. http://proquest.umi.com/pqdweb?did=1805164991&sid=2&Fmt=2&clientId=3507&RQT=309&VName=PQD.

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31

Bendre, Ashish R. "A computer model of the cochlea using realizable feedback from motile outer hair cells." 1992. http://catalog.hathitrust.org/api/volumes/oclc/31746972.html.

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Thesis (M.S.)--University of Wisconsin--Madison, 1992.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaf 66).

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32

Buscone, S., Andrei N. Mardaryev, B. Raafs, et al. "A new path in defining light parameters for hair growth: discovery and modulation of photoreceptors in human hair follicle." 2017. http://hdl.handle.net/10454/12062.

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Yes<br>Background and Objective: Though devices for hair growth based on low levels of light have shown encouraging results, further improvements of their efficacy is impeded by a lack of knowledge on the exact molecular targets that mediate physiological response in skin and hair follicle. The aim of this study was to investigate the expression of selected light-sensitive receptors in the human hair follicle and to study the impact of UV-free blue light on hair growth ex vivo. Material and Methods: The expression of Opsin receptors in human skin and hair follicles has been characterise

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33

"Biophysical Interactions of the OHC Motor Protein Prestin: A Study at the Single Molecule Level." Thesis, 2011. http://hdl.handle.net/1911/70287.

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The exquisite frequency selectivity and amplification characteristics of mammalian hearing intimately depend on the fast electromechanical motion of the outer hair cells in the cochlea. This membrane based process, termed electromotility, is driven by the protein prestin which is uniquely present in the OHC lateral wall. Voltage dependent motility, in OHCs and mammalian cells expressing prestin, is accompanied by intramembranous charge movement which is widely considered a signature of electromotility and prestin function. How prestin converts changes in membrane potential into axial length ch

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34

Ya-Fang and 鄧雅方. "The study of the effect of Nitric Oxide on the Voltage-Dependant K＋Current of Outer Hair Cells in guinea pig cochlea." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/15754176458930854016.

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碩士<br>中山醫學大學<br>醫學研究所<br>95<br>The purpose of the present investigation is to study the effect of NO and NO/cGMP pathway on the potassium current of outer hair cells. This study utilized isolated guinea-pig outer hair cells and the whole cell patch-clamp technique to determine whether NO and NO/cGMP signaling pathway involved in modulating the K+ channels of outer hair cells. The isolated outer hair cells were divided into seven groups as follows: group 1 treated with 3,4-diaminopyridine (3,4-DAP); group 2 with L-arginine (L-Arg); group 3 with NG-nitro-L-arginine methyl ester hydrochlori

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35

Lin, Kuang-Yi, and 林光義. "Theoretic analysis of effects on hearing curves by outer hair cell nonlinear capacitance." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/27821107622262248736.

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碩士<br>國立清華大學<br>電機工程學系<br>101<br>Two mechanisms have been proposed for outer hair cells(OHCs) mediated amplification in mammalian cochlea : a hair-bundle(HB) motility generated during mechano-electrial transduction(MET) and a somatic motility generated by motor protein prestin in the outer hair cell lateral membrane. Both mechanisms are nonlinear. In the first section, this thesis uses computer models to simulate the outer hair cell fast effect by efferent control from medial olivocochlea interneuron. The middle-ear to inner ear and outer hair cell model proposed by Liu and Neely in 2009 and 2

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36

Organ, Louise E. "Investigating the lateral mobility of outer hair cell plasma membrane constituents by fluorescence recovery after photobleaching." Thesis, 2008. http://hdl.handle.net/1911/22165.

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Mammalian hearing exhibits exquisite sensitivity and frequency selectivity attributed to the unique properties of cochlear outer hair cells (OHCs). These sensory epithelial cells are electro-mechanical transducers, capable of converting sound-induced electrical signals into mechanical forces which provide feedback via a mechanism known as the cochlear amplifier. In a process aptly termed electromotility, electro-mechanical transduction manifests as whole-cell axial length changes in OHCs that occur in response to changes in the transmembrane potential. The polytopic motor protein prestin funct

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37

Greeson, Jennifer N. "Investigating the role of the outer hair cell plasma membrane in electromotility and prestin function using quantitative optical microscopy techniques." Thesis, 2008. http://hdl.handle.net/1911/22210.

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Almost 25 years ago, the unique electromotile activity of mammalian outer hair cells (OHCs) was discovered. This cylindrical neuro-epithelial cell is capable of transducing changes in transmembrane potential into whole-cell axial deformations. The resulting contractions and elongations feedback into the sound-induced vibrations of the basilar membrane, enhancing hearing sensitivity and frequency detection capabilities. Although the complete mechanism of electromotility is not presently understood, the discovery and localization of the putative motor protein, prestin, to the OHC plasma membrane

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38

Fleischer, Mario. "Mehrfeldmodellierung und Simulation der äußeren Haarsinneszelle der Cochlea." Doctoral thesis, 2011. https://tud.qucosa.de/id/qucosa%3A26314.

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Das Innenohr des Säugetieres ist ein hochspezialisiertes sensorisches System, das durch ein komplexes mechanisches Verhalten gekennzeichnet ist. Neben der komplizierten Morphometrie und Geometrie kommen auch dem richtungsabhängigen Materialverhalten eine wesentliche Bedeutung zu. Es zeigt sich, daß im Cortischen Organ mit der äußeren Haarsinneszelle ein Zelltyp vorliegt, der durch seine physikalischen Eigenschaften das Gesamtverhalten des Innenohres maßgeblich beeinflußt. Wie jede tierische Zelle weist die äußere Haarsinneszelle als biomechanisches System eine heterogene Mikrostruktur auf. Vom

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