Journal articles: 'Outside therapy'

1

Little, Rosaleen. "Representation on Outside Organisations." Physiotherapy 75, no. 1 (1989): 29. http://dx.doi.org/10.1016/s0031-9406(10)62933-1.

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Betts, James A., and Dylan Thompson. "Thinking outside the Bag (Not Necessarily outside the Lab)." Medicine & Science in Sports & Exercise 44, no. 10 (2012): 2040. http://dx.doi.org/10.1249/mss.0b013e318264526f.

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Beames, Simon, and Hamish Ross. "Journeys outside the classroom." Journal of Adventure Education & Outdoor Learning 10, no. 2 (2010): 95–109. http://dx.doi.org/10.1080/14729679.2010.505708.

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Barnitt, Rosemary E. "Editorial – A view from outside." Physiotherapy Research International 9, no. 1 (2004): iii—iv. http://dx.doi.org/10.1002/pri.294.

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Pope, Kenneth S. "How people change inside and outside therapy." Clinical Psychology Review 13, no. 3 (1993): 296–97. http://dx.doi.org/10.1016/0272-7358(93)90026-i.

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Mellinger, John D. "Endoluminal GERD therapy: inside, outside, upside, downside." Surgical Endoscopy 21, no. 5 (2007): 695–96. http://dx.doi.org/10.1007/s00464-007-9343-4.

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Reider, Bruce. "Thinking outside the Box." American Journal of Sports Medicine 33, no. 5 (2005): 645. http://dx.doi.org/10.1177/0363546505276271.

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Dave, Lee Yee Han, and David N. M. Caborn. "Outside-In Meniscus Repair." Sports Medicine and Arthroscopy Review 20, no. 2 (2012): 77–85. http://dx.doi.org/10.1097/jsa.0b013e318254966a.

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Poyade, Matthieu, Glyn Morris, Ian C. Taylor, and Victor Portela. "iSenseVR: bringing VR exposure therapy outside the laboratory." Journal of Enabling Technologies 13, no. 2 (2019): 123–34. http://dx.doi.org/10.1108/jet-12-2018-0063.

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PurposeThe purpose of this paper is to present the preliminary outcomes of a research which takes gradual exposure in virtual reality (VR) outside the laboratory to empower people with “hidden disabilities” breaking down their barriers towards independent living. It explores the use of VR through smartphones to practically apply gradual exposure to environment stressors that are typically found in busy spaces from one’s own safe environment.Design/methodology/approachAberdeen International Airport has kindly accepted to take part to this research as a case study. Following a participatory design and usability testing, a semi-controlled seven-day study was conducted among seven individuals with hidden disabilities to assess user acceptance.FindingsResults showed undeniable participants’ engagement and enthusiasm for the proposed approach, although further research is needed to increase the presence and improve the overall user experience.Research limitations/implicationsThe proposed research has been conducted on small cohort of participants outside of a clinical setting. Further engagement with individuals with hidden disabilities is required in order to determine the effectiveness of the proposed approach.Originality/valueThis research presents a methodological and technological framework which contributes effectively to the practicality of VR exposure therapy outside of the laboratory setting, from one’s own safe place.

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Luchetti, Martina, Nicolino Rossi, and Ornella Montebarocci. "Brief report: Collecting self-defining memories outside therapy." Clinical Psychologist 20, no. 2 (2013): 80–85. http://dx.doi.org/10.1111/cp.12032.

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Swift, Joshua K., Jennifer L. Callahan, Gregory L. Herbert, and Christopher J. Heath. "Naturalistic Changes in Subjective Distress Outside of Therapy." Journal of Clinical Psychology 68, no. 4 (2012): 421–31. http://dx.doi.org/10.1002/jclp.20869.

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Shinoura, Nobusada, Yuichi Suzuki, Yasuko Watanabe, et al. "Mirror therapy activates outside of cerebellum and ipsilateral M1." NeuroRehabilitation 23, no. 3 (2008): 245–52. http://dx.doi.org/10.3233/nre-2008-23306.

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Lawson, Thomas. "Editor's Message: IV Therapy Outside and Inside the U.S." Journal of Vascular Access Devices 3, no. 3 (1998): 5. http://dx.doi.org/10.2309/108300898775992860.

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Tuastad, Lars, and Lucy O'Grady. "Music therapy inside and outside prison – A freedom practice?" Nordic Journal of Music Therapy 22, no. 3 (2013): 210–32. http://dx.doi.org/10.1080/08098131.2012.752760.

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Hoffman, M. "Gene therapy. New vector puts payload on the outside." Science 256, no. 5056 (1992): 445. http://dx.doi.org/10.1126/science.1570507.

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Armstrong, Michael B. "Proteasome Inhibition: Thinking outside the Box." Clinical Medicine. Therapeutics 1 (January 2009): CMT.S3072. http://dx.doi.org/10.4137/cmt.s3072.

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A new era in cancer therapy is emerging with the development of tumor-specific agents exhibiting less toxicity. Since the advent of imatinib, several tumor-directed treatment options have been developed. However, therapies not directed specifically at a tumor target also have potential benefits. The 26S proteasome is a critical regulator of cell homeostasis through the degradation of key signaling molecules including p21, p27, and p53. Additionally, the proteasome degrades I-κB which inhibits the activity of NF-κB, an important promoter of cell proliferation. Blocking function of the proteasome disrupts tumor growth by shifting the balance of the cell from proliferation to apoptosis. In vitro, the proteasome inhibitor, bortezomib, inhibits NF-κB activity and prevents growth of several malignant cell types including multiple myeloma. Given the central role of NF-κB in the pathogenesis of multiple myeloma, bortezomib was a good candidate for use in therapy. Treatment of heavily pre-treated patients with bortezomib led to response rates of 30%-40%. More importantly, bortezomib led to improvements in bone metabolism, a major cause of morbidity in multiple myeloma. This effect was seen independent of the response of the myeloma. This finding correlates with in vitro studies which demonstrate increased BMP2 expression and osteoblast number after exposure to bortezomib. Moreover, bortezomib blocks NF-κB-mediated angiogenesis and tumor cell metastasis. While tumor-targeted treatments have an important role in the future of cancer therapy, these examples show that it is important not to lose sight of the benefits of less-specific agents in the treatment of malignant neoplasms.

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Warner, Jon J. P., Mark D. Miller, and Russell F. Warren. "Meniscal Repair Using the Outside-In Technique." Sports Medicine and Arthroscopy Review 1, no. 2 (1993): 145–51. http://dx.doi.org/10.1097/00132585-199300120-00007.

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Singh, Preet Mohinder, Anuradha Borle, and Basavana G. Goudra. "Use of computer-assisted drug therapy outside the operating room." Current Opinion in Anaesthesiology 29, no. 4 (2016): 506–11. http://dx.doi.org/10.1097/aco.0000000000000345.

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Kareem, Jafar. "Outside in… inside out… some considerations in intercultural psycho-therapy." Journal of Social Work Practice 3, no. 3 (1988): 57–71. http://dx.doi.org/10.1080/02650538808413384.

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Winter, Sandra, Mary Jeghers, Emily Reid, Cassandra McGowan, Mary Ellen Young, and Sherrilene Classen. "Driving Outside the Wire: Examining Factors Impacting Veterans’ Postdeployment Driving." OTJR: Occupation, Participation and Health 40, no. 4 (2020): 235–44. http://dx.doi.org/10.1177/1539449220914533.

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Combat Veterans (CVs) deployed to Iraq or Afghanistan experience driving difficulty, based on medical conditions and/or deployment exposures, elevating their risk of motor vehicle crash-related injury or death. To address grounded theory rigor and incorporate constructs such as the Person Environment Occupation Performance model, we revised the Hannold et al. (2013) conceptual framework. We conducted two focus groups with seven CVs. Conceptual framework revisions were based on an iterative process and thematic analysis. We elicited CVs’ perspectives on deployment training, driving pre- and postdeployment, strategies, and intervention preferences. Personal, environmental, and task factors underpinned CVs’ driving. Participants described triggers (e.g., stressful stimuli), use of environmental (e.g., car controls) or personal (e.g., avoiding traffic) strategies, and outcomes of appropriate or risky driving. Findings illustrated CVs’ driving difficulty and informed development of a Veteran-centric driving intervention. Improving driving fitness has implications for Veterans’ participation and community integration.

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Rio, Ebonie, Dawson Kidgell, G. Lorimer Moseley, and Jill Cook. "87 Patellar Tendinopathy: Looking Outside The Tendon…" British Journal of Sports Medicine 48, Suppl 2 (2014): A57.1—A57. http://dx.doi.org/10.1136/bjsports-2014-094114.86.

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Wittig, Joan, and Jean Davis. "Circles outside the circle: Expanding the group frame through dance/movement therapy and art therapy." Arts in Psychotherapy 39, no. 3 (2012): 168–72. http://dx.doi.org/10.1016/j.aip.2011.12.012.

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Schulte, Kary R., and Freddie H. Fu. "Meniscal Repair Using The Inside-To-Outside Technique." Clinics in Sports Medicine 15, no. 3 (1996): 455–67. http://dx.doi.org/10.1016/s0278-5919(20)30105-8.

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Rodeo, Scott A., and Russell F. Warren. "Meniscal Repair Using The Outside-To-Inside Technique." Clinics in Sports Medicine 15, no. 3 (1996): 469–81. http://dx.doi.org/10.1016/s0278-5919(20)30106-x.

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Rodeo, Scott A., and Aruna M. Seneviratne. "Arthroscopic Meniscal Repair Using the Outside-In Technique." Sports Medicine and Arthroscopy Review 7, no. 1 (1999): 20–27. http://dx.doi.org/10.1097/00132585-199901000-00003.

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Artho, Paul A., Jason G. Thyne, Barry P. Warring, Chris D. Willis, Jean-Michel Brismée, and Neal S. Latman. "A Calibration Study of Therapeutic Ultrasound Units." Physical Therapy 82, no. 3 (2002): 257–63. http://dx.doi.org/10.1093/ptj/82.3.257.

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Abstract Background and Purpose. Physiological effects of therapeutic ultrasound (US) are dependent on the intensity and duration of application. The purpose of this study was to test US machines used in clinical settings for proper calibration of time and power output. Methods. Measurements of power output and timer accuracy were obtained from 83 US units in clinical use. The machines were tested at 4 intensity settings (0.5, 1.0, 1.5, and 2.0 W/cm2) using a continuous waveform and a 1-MHz frequency. The measured intensities were converted to percentages of error and compared with the ±20% standard. Results. Of the machines tested, 32 (39%) were outside the calibration standard for at least one output setting. Of these machines, 15 (18%) were above the +20% standard, and 17 (21%) were below the −20% standard for at least one output setting. Of the 32 machines outside the standard, 26 (31%) were outside the standard for 2 or more settings, and 3 (4%) produced no output at any of the settings. Of the mechanical timers tested, 7 (28%) were outside of the ±10% standard for timer accuracy at the 5-minute interval, and 6 (24%) were outside of the standard at the 10-minute interval. All digital timers tested were within the standard. Discussion and Conclusion. More than one third of machines tested in this study were outside the standard for power output, and approximately one fourth of the mechanical timers were outside the standard. Therefore, further improvements in the accuracy of US machine calibration are needed.

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Eng, Xue Wen, Sandra G. Brauer, Suzanne S. Kuys, Matthew Lord, and Kathryn S. Hayward. "Factors Affecting the Ability of the Stroke Survivor to Drive Their Own Recovery outside of Therapy during Inpatient Stroke Rehabilitation." Stroke Research and Treatment 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/626538.

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Aim. To explore factors affecting the ability of the stroke survivor to drive their own recovery outside of therapy during inpatient rehabilitation.Method. One-on-one, in-depth interviews with stroke survivors (n=7) and their main carer (n=6), along with two focus groups with clinical staff (n=20). Data was thematically analysed according to group.Results. Stroke survivors perceived “dealing with loss,” whilst concurrently “building motivation and hope” for recovery affected their ability to drive their own recovery outside of therapy. In addition, they reported a “lack of opportunities” outside of therapy, with subsequent time described as “dead and wasted.” Main carers perceived stroke survivors felt “out of control … at everyone’s mercy” and lacked knowledge of “what to do and why” outside of therapy. Clinical staff perceived the stroke survivor’s ability to drive their own recovery was limited by the lack of “another place to go” and the “passive rehab culture and environment.”Discussion. To enable the stroke survivor to drive their own recovery outside of therapy, there is a need to increase opportunities for practice and promote active engagement. Suggested strategies include building the stroke survivor’s motivation and knowledge, creating an enriched environment, and developing daily routines to provide structure outside of therapy time.

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Olofsson, Alexandra, Anneli Nyman, and Maria Larsson Lund. "Occupations outside the home: Experiences of people with acquired brain injury." British Journal of Occupational Therapy 80, no. 8 (2017): 486–93. http://dx.doi.org/10.1177/0308022617709165.

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Peppercorn, J., S. Joffe, H. J. Burstein, and E. Winer. "Use of experimental therapy outside of clinical trials among U.S. oncologists." Journal of Clinical Oncology 24, no. 18_suppl (2006): 6047. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.6047.

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6047 Background: Investigational cancer therapies being tested in clinical trials may be available outside of trials, or “off-protocol” (OPRx). There are no published data on either the frequency of OPRx or the attitudes of physicians towards OPRx. Methods: In spring 2005, we surveyed a random sample of American medical oncologists chosen from the ASCO directory regarding their attitudes and practices surrounding OPRx. We evaluated the correlation between demographic factors, attitudes, use of OPRx, and response to hypothetical cases. All statistical tests were two-sided. Results: 146 of 471 (31%) oncologists responded. 93% reported ever discussing OPRx and 81% ever prescribing OPRx. 66% reported prescribing OPRx ≥ once/year and 12% ≥ once/month. 68% reported denying requests for OPRx ≥ once/year and 6% ≥ once/month. Academic oncologists were simultaneously more likely than community oncologists to have ever provided OPRx (89% v. 75%, p = 0.06 by Fisher’s exact test), to discuss OPRx ≥ 1 month (45% v. 12%, p = .003), and to deny requests for OPRx ≥ 1 month (15% v. 2%, p = 0.02). While 61% of oncologists believe that patients should be discouraged from OPRx, only 31% felt it should not be available. 53% felt that patients considering trial enrollment should be informed if OPRx is available, whereas 34% disagreed. 26% felt that patients considering enrollment have a right to OPRx, whereas 56% disagreed. Neither practice setting nor other demographic factors predicted attitudes towards OPRx. For hypothetical cases, there was little consensus regarding when to prescribe OPRx. For example, prior to the release of data from recent trials, 41% reported that they would prescribe adjuvant trastuzumab OPRx at a patient’s request. Factors correlating with willingness to provide OPRx included non-academic practice setting (p = 0.04), > 15 years in practice (p = 0.08), belief that non-trial care and trial care are equivalent (p = 0.01) and belief that patients have a right to OPRx (p = 0.004). Conclusion: American oncologists commonly discuss and provide OPRx. Attitudes towards and utilization of OPRx vary substantially in the oncology community. Further discussion of OPRx and guideline development appear warranted. No significant financial relationships to disclose.

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Hamilton, E. P., G. H. Lyman, S. Kim, and J. Peppercorn. "Availability of experimental therapy outside of randomized clinical trials in oncology." Journal of Clinical Oncology 27, no. 15_suppl (2009): 6539. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.6539.

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6539 Background: Investigational cancer therapies may be available outside of trials, or “off protocol” (OPRx), with implications for patient safety, trial accrual, and access to care. Previous studies suggest OPRx is prevalent in oncology, but there is little consensus on when it should or should not be considered. We evaluated the scope and impact of OPRx through assessment of availability of the experimental arms of recent randomized trials (RCT), and evaluation of study outcomes and accrual. Methods: We conducted a Medline search to identify all English language phase III RCT of medical interventions in oncology over a 2-year period ending April 17, 2008. We determined availability of experimental interventions based on FDA approval for any indication. We limited assessment of accrual (time to trial completion, patients/month) to studies with US sites. Significance of results was assessed by Fisher's exact test and unpaired t-test. Results: We identified 172 eligible RCT. The majority of RCT (108, 63%) evaluated drugs that were available OPRx at trial initiation, while an additional 19 (11%) trial drugs became available during the trial. 64 (55%) were available due to FDA approval for the same cancer in a different setting, 40 (35%) for a different cancer, and 12 (10%) for a non-cancer indication. 25% of trials were conducted at only US sites, 15% included US and international sites, and 60% were international only. Trials in which OPRx was available had slower time to completion compared to trials in which OPRx was unavailable (48 vs. 26 months, p = 0.04) and a trend towards slower accrual (14.0 vs. 40.7 patients/month, p = 0.06). For the majority of RCT (66%), there was at least one grade 3/4 toxicity that was greater in the experimental arm, for 47% the experimental interventions proved superior for 1 major outcome, and 27% demonstrated improvement in overall survival. These outcomes did not vary based on availability OPRx. Conclusions: The majority of recent oncology trials involve experimental regimens that are available outside of a trial. The safety and efficacy of novel interventions must be determined by trials but availability of OPRX may impact accrual. Guidelines are needed for OPRx in oncology. No significant financial relationships to disclose.

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Hall, Kelvin. "How the Outside Comes Inside: Ecological Selves in the Therapy Room." Self & Society 41, no. 4 (2014): 22–27. http://dx.doi.org/10.1080/03060497.2014.11084383.

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Cao, K. I., K. Kirov, I. Kriegel, et al. "Implantable Drug Delivery Systems Should Be Inserted Outside Radiation Therapy Fields." International Journal of Radiation Oncology*Biology*Physics 93, no. 3 (2015): E574. http://dx.doi.org/10.1016/j.ijrobp.2015.07.2015.

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Brammer, Robert, and Kumar Vipul. "Failing All Therapy for COPD: Time to Think Outside the Box." Chest 150, no. 4 (2016): 1249A. http://dx.doi.org/10.1016/j.chest.2016.08.1362.

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Sloan Donachy, Gillian. "Psychotherapy outside the consulting room: ending therapy during the global pandemic." Journal of Child Psychotherapy 46, no. 3 (2020): 373–79. http://dx.doi.org/10.1080/0075417x.2021.1903065.

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Olofsson, Alexandra, Anneli Nyman, Ann Charlotte Kassberg, Camilla Malinowsky, and Maria Larsson Lund. "Places visited for activities outside the home after stroke: Relationship with the severity of disability." British Journal of Occupational Therapy 83, no. 6 (2019): 405–12. http://dx.doi.org/10.1177/0308022619879075.

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Introduction Knowledge about the places people visit or do not visit after stroke is lacking. The aim of this study was to describe and compare the places visited for activities outside the home of people with stroke of working age and to explore the influence of the severity of disability, fatigue, driving a car and sociodemographic characteristics on the total number of places visited for activities outside the home. Methods An exploratory cross-sectional study was conducted and 63 people with stroke were interviewed with instruments that covered places outside the home, severity of disability and fatigue. Data were analysed using non-parametric tests, analysis of variance and the general linear model. Results Significant difference in the total number of places visited for activities outside the home were found between all three groups of severity of disability. The good recovery group visited eight places to a significantly higher extent than those with severe/moderate disability. The severity of disability and driving a car were the only aspects that significantly influenced the total number of places visited. Conclusions Places for activities outside the home people with stroke visit and changes therein can add valuable knowledge about participation that can be used in the design of rehabilitation.

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Margot-Cattin, Isabel, Catherine Ludwig, Nicolas Kühne, et al. "Visiting Out-of-Home Places When Living With Dementia: A Cross-Sectional Observational Study: Visiter des lieux hors du domicile lorsque l'on vit avec une démence: étude transversale observationnelle." Canadian Journal of Occupational Therapy 88, no. 2 (2021): 131–41. http://dx.doi.org/10.1177/00084174211000595.

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Background. Persons living with dementia face a reduction of their life space outside home and disengagement from participation, linked to places visited. Purpose. This study explored stability and change in perceived participation in places visited outside home and its relationship with occupational gaps among older adults. Method. Older adults living with ( n = 35) or without ( n = 35) dementia were interviewed using the Participation in ACTivities and Places OUTside Home (ACT-OUT) questionnaire and the Occupational Gaps Questionnaire (OGQ). Data analysis used descriptive and inferential statistics. Findings. The group of people living with dementia reported significantly fewer places ( p < .001) visited than the comparison group and having abandoned more places visited ( p < .001) than the comparison group. The number of occupational gaps was significantly different between groups ( p < .001). Implications. Participation outside home is not influenced in a uniform and straightforward way for persons living with dementia; the shrinking world effect appears differently in relation to types of places.

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Geraerts, Elke, Jonathan W. Schooler, Harald Merckelbach, Marko Jelicic, Beatrijs J.A. Hauer, and Zara Ambadar. "The Reality of Recovered Memories." Psychological Science 18, no. 7 (2007): 564–68. http://dx.doi.org/10.1111/j.1467-9280.2007.01940.x.

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Although controversy surrounds the relative authenticity of discontinuous versus continuous memories of childhood sexual abuse (CSA), little is known about whether such memories differ in their likelihood of corroborative evidence. Individuals reporting CSA memories were interviewed, and two independent raters attempted to find corroborative information for the allegations. Continuous CSA memories and discontinuous memories that were unexpectedly recalled outside therapy were more likely to be corroborated than anticipated discontinuous memories recovered in therapy. Evidence that suggestion during therapy possibly mediates these differences comes from the additional finding that individuals who recalled the memories outside therapy were markedly more surprised at the existence of their memories than were individuals who initially recalled the memories in therapy. These results indicate that discontinuous CSA memories spontaneously retrieved outside of therapy may be accurate, while implicating expectations arising from suggestions during therapy in producing false CSA memories.

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Ringsby Jansson, Bibbi, and Sören Olsson. "Outside the System: Life Patterns of Young Adults with Intellectual Disabilities." Scandinavian Journal of Disability Research 8, no. 1 (2006): 22–37. http://dx.doi.org/10.1080/15017410500301122.

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URSO, MARIA L. "Regulation of Muscle Atrophy: Wasting Away from the Outside In." Medicine & Science in Sports & Exercise 41, no. 10 (2009): 1856–59. http://dx.doi.org/10.1249/mss.0b013e3181a643b2.

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Branam, Barton R., and Christopher J. Utz. "Indications for Two-Incision (Outside-In) Anterior Cruciate Ligament Reconstruction." Clinics in Sports Medicine 36, no. 1 (2017): 71–86. http://dx.doi.org/10.1016/j.csm.2016.08.004.

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Van Norden, Sharon, and Renate Bik. "WHY ARE MANUFACTURERS LAUNCHING CLINICAL TRIALS FOR GENE THERAPY OUTSIDE THE NETHERLANDS?" Amsterdam Law Forum 12, no. 2 (2020): 78. http://dx.doi.org/10.37974/alf.357.

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Jordan, Martin. "Moving beyond counselling and psychotherapy as it currently is – taking therapy outside." European Journal of Psychotherapy & Counselling 16, no. 4 (2014): 361–75. http://dx.doi.org/10.1080/13642537.2014.956773.

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Bradley, Paul, and Joseph D. Tobias. "An Evaluation of the Outside Therapy of Diabetic Ketoacidosis in Pediatric Patients." American Journal of Therapeutics 15, no. 6 (2008): 516–19. http://dx.doi.org/10.1097/mjt.0b013e318172771b.

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Polf, J. C., W. D. Newhauser, and U. Titt. "Patient neutron dose equivalent exposures outside of the proton therapy treatment field." Radiation Protection Dosimetry 115, no. 1-4 (2005): 154–58. http://dx.doi.org/10.1093/rpd/nci264.

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Gutierrez, Kathleen. "Continuation of Antibiotic Therapy for Serious Bacterial Infections Outside of the Hospital." Pediatric Annals 25, no. 11 (1996): 639–45. http://dx.doi.org/10.3928/0090-4481-19961101-10.

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Kapasi, Zoher F., and Beth P. Davis. "Looking Outside Health Care to Teach Innovation in Physical Therapy Business Practice." Journal of Physical Therapy Education 31, no. 4 (2017): 40–48. http://dx.doi.org/10.1097/jte.0000000000000013.

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Sandberg, Larry S., and Suzi Tortora. "Thinking (And Moving) Outside the Box: Psychoanalytic Treatment and Dance/Movement Therapy." Psychoanalytic Quarterly 88, no. 4 (2019): 839–65. http://dx.doi.org/10.1080/00332828.2019.1652061.

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Savelsbergh, Geert J. P., and J. Bernard Netelenbos. "Can the Developmental Lag in Motor Abilities of Deaf Children Be Partly Attributed to Localization Problems?" Adapted Physical Activity Quarterly 9, no. 4 (1992): 343–52. http://dx.doi.org/10.1123/apaq.9.4.343.

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Spatial information for the execution of motor behavior is acquired by orienting eye and head movements. This information can be found in our direct field of view as well as outside this field. Auditory information is especially helpful in directing our attention to information outside our initial visual field of view. Two topics on the effect of an auditory loss are discussed. Experimental evidence is provided which shows that deaf children have problems in orienting to visual stimuli situated outside their field of view. An overview is given from several studies in which the eye and head movements of deaf children are analyzed. Second, it is suggested that specific visual localization problems are partly responsible for deaf children’s characteristic lag in motor development. The latter is illustrated in two studies involving the gross motor task of ball catching.

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Wade, Jarrod, Joel Fuller, Paul Devlin, and Timothy L. A. Doyle. "Lower body peak force but not power is an important discriminator of elite senior rugby league players." Kinesiology 52, no. 1 (2020): 109–14. http://dx.doi.org/10.26582/k.52.1.14.

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This investigation determined differences in lower body strength and power between elite junior (17-20 years) and elite senior (open-aged) rugby league athletes. Twenty junior and 25 senior athletes performed an isometric mid-thigh pull, countermovement jump, repeated jump, and broad jump tests during a National Rugby League pre-season. The effects of age (junior vs. senior) and position (adjustables vs. hit-up forwards vs. outside backs) on test results were investigated using a two-way analysis of variance. Cohen’s d effect sizes (ES) and 95% confidence intervals were calculated for pairwise comparisons. Isometric mid-thigh pull absolute peak force was greater for senior players compared to junior players (ES=0.88, p&lt;.05). Countermovement jump absolute peak power was greater for outside backs (ES=1.12) and hit-up forwards (ES=1.23) compared to adjustables (p&lt;.05), greater for senior outside backs compared to junior outside backs (ES=1.53, p&lt;.05), and greater for junior hit-up forwards compared to senior hit-up forwards (ES=1.00, p&lt;.05). This research demonstrated the differences in strength and power of rugby league athletes between playing age and position. Improving lower body strength should be prioritised for athletic development of junior rugby league athletes, with consideration given to requirements across different playing positions.

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Mandrekar, Sumithra J., Suzanne E. Dahlberg, and Richard Simon. "Improving Clinical Trial Efficiency: Thinking outside the Box." American Society of Clinical Oncology Educational Book, no. 35 (May 2015): e141-e147. http://dx.doi.org/10.14694/edbook_am.2015.35.e141.

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Abstract:

Clinical trial design strategies have evolved over the past few years as a means to accelerate the drug development process so that the right therapies can be delivered to the right patients. Basket, umbrella, and adaptive enrichment strategies represent a class of novel designs for testing targeted therapeutics in oncology. Umbrella trials include a central infrastructure for screening and identification of patients, and focus on a single tumor type or histology with multiple subtrials, each testing a targeted therapy within a molecularly defined subset. Basket trial designs offer the possibility to include multiple molecularly defined subpopulations, often across histology or tumor types, but included in one cohesive design to evaluate the targeted therapy in question. Adaptive enrichment designs offer the potential to enrich for patients with a particular molecular feature that is predictive of benefit for the test treatment based on accumulating evidence from the trial. This review will aim to discuss the fundamentals of these design strategies, the underlying statistical framework, the logistical barriers of implementation, and, ultimately, the interpretation of the trial results. New statistical approaches, extensive multidisciplinary collaboration, and state of the art data capture technologies are needed to implement these strategies in practice. Logistical challenges to implementation arising from centralized assay testing, requirement of multiple specimens, multidisciplinary collaboration, and infrastructure requirements will also be discussed. This review will present these concepts in the context of the National Cancer Institute's precision medicine initiative trials: MATCH, ALCHEMIST, Lung MAP, as well as other trials such as FOCUS4.

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