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Dissertations / Theses on the topic 'Ovarian cell'

Author: Grafiati

Published: 3 June 2025

Last updated: 1 August 2025

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1

Fruka, Tayra. "An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines." University of the Western Cape, 2019. http://hdl.handle.net/11394/6920.

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Philosophiae Doctor - PhD<br>Introduction: Globally, there are over 190,000 new reported cases of ovarian cancers per annum. This comprises 3% to 4% of all cancers in women. Ovarian cancer is one of the leading causes of deaths in women. Ovarian cancer is the second most diagnosed gynaecological malignancy and over all the fifth cause leading to death among all types of cancer in the UK in 2004. More than 70% of epithelial ovarian cancers are diagnosed at an advanced stage. Consequently, the prognosis is poor and the mortality rate high. Thus, the survival rate is affected by how far the disea

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2

Park, Se Hyung. "Estrogen in ovarian cancer cell metastasis." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1287.

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Benign ovarian tumors and majority of epithelial ovarian cancers possess steroid receptors including estrogen receptors (ERs). However, the estrogen-ER signaling in ovarian carcinomas is not completely understood. Tumorigenesis is a multiple-step process involving dysregulated cell growth and metastasis. Tumor cells acquire the capacity of migration and invasion by temporal phenotypical and genotypical changes termed epithelial-mesenchymal transition (EMT). Considerable evidence implicates a mitogenic action of estrogen in early ovarian carcinogenesis. In contrast, its influence in the metasta

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3

Hosseini, Shirazi Seyed Farshad. "Cell cycle dependency of cisplatin cytotoxicity on ovarian cancer cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0028/NQ36776.pdf.

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4

Vandermeer, Lisa Anne. "Evaluation of c-KIT in ovarian surface epithelial cells and ovarian tumours." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/27067.

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Ovulation is a putative risk factor for ovarian cancer, and may be attributed to proliferating ovarian surface epithelial (OSE) cells interacting with the extracellular matrix (ECM) during ovulatory wound repair. We investigated the effects of ECM and cellular density on OSE cell morphology, proliferation, and expression of c-Kit, a proto-oncogene expressed in 70% of ovarian tumours. Fibrillar collagen I caused significant changes in morphology and proliferation but monomeric ECM had no effect. Normal human ovaries co-expressed KIT, collagen I and fibronectin in 75% of abnormal OSE structures.

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5

Yang, Ya-Ting. "Molecularly targeted therapy for ovarian cancer." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1149015359.

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6

Dhar, Anita. "Morphometric studies on the human ovarian granulosa cell." Thesis, [Hong Kong : University of Hong Kong], 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13829889.

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7

Breznan, Anna Devorah. "Oligonucleotide microarray analysis of chromosome 17 gene expression in a model human epithelial ovarian cancer cell line, TOV112D, and in epithelial ovarian tumors and ovarian malignant ascites." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97911.

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The importance of developing relevant ovarian cancer models led us to test the applicability of a system comprised of epithelial ovarian cancer cell lines. The high frequency of loss of heterozygosity (LOH) and rearrangements of chromosome 17 in ovarian tumors provide evidence of a role of chromosome 17 genes in ovarian tumorigenesis. Oligonucleotide microarray expression analysis was applied to assess the expression profiles of 864 probe sets that map to chromosome 17. The TOV112D ovarian cancer cell line, a spontaneously immortalized and tumorigenic ovarian cancer cell line derived from an e

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8

Turner, Ian Matthew. "Effects of sex steroids on ovarian granulosa cell function." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/20849.

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The studies described in this thesis were concerned with the role of sex steroids in the control of the differentiation of ovarian granulosa cells. This process is driven by FSH, but is subject to the influence of locally produced factors which are thought to be critical of determining the fate of a follicle. Androgens and oestrogens were known to augment the action of FSH on granulosa cell steroidogenesis, with androgens being the more potent. However, little was known about their mechanism of action, or their effects at the level of gene expression and protein synthesis. Therefore, a rat gra

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9

Maxwell, Tammy Joy. "Dendritic cell mRNA delivery strategies for ovarian cancer immunotherapy." Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16495/1/Tammy_Maxwell_Thesis.pdf.

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Ovarian cancer, with the highest mortality rate amongst gynaecological malignancies in Australia, is the eighth most common cancer and the fifth cause of cancer-related deaths in women. Currently, five-year survival for women diagnosed with ovarian cancer is only 40 % and despite many patients experiencing remission, approximately 80 % of them will relapse due to residual micrometastasis. The limited impact of standard therapies on the prognosis for recurrent chemotherapy-resistant disease and the need to identify less toxic alternatives has motivated the development of strategies to combat

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10

Maxwell, Tammy Joy. "Dendritic cell mRNA delivery strategies for ovarian cancer immunotherapy." Queensland University of Technology, 2007. http://eprints.qut.edu.au/16495/.

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Ovarian cancer, with the highest mortality rate amongst gynaecological malignancies in Australia, is the eighth most common cancer and the fifth cause of cancer-related deaths in women. Currently, five-year survival for women diagnosed with ovarian cancer is only 40 % and despite many patients experiencing remission, approximately 80 % of them will relapse due to residual micrometastasis. The limited impact of standard therapies on the prognosis for recurrent chemotherapy-resistant disease and the need to identify less toxic alternatives has motivated the development of strategies to combat

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11

Xu, Wenwei. "Investigation of stiffness as a biomarker in ovarian cancer cells." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/50381.

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In this dissertation, we developed cell stiffness as a biomarker in ovarian cancer for the purpose of grading metastatic potential. By measuring single cell stiffness with atomic force microscopy and quantifying in vitro invasiveness of healthy and cancerous ovarian cells, we demonstrated that cancerous ovarian cells have reduced stiffness compared to the healthy ones and invasive ovarian cancer cells are more deformable than noninvasive ovarian cancer cells. The difference in cell stiffness between two genetically similar cell lines was attributed to actin-mediated cytoskeletal remodeling as

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12

Soboloff, Jonathan. "Regulation of hen granulosa cell fate during ovarian follicular development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0012/NQ38799.pdf.

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13

Chung, Chin-man. "Involvement of chromosome 20q in the immortalization of human ovarian surface epithelial cells." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971672.

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14

McKenzie, Andrew J. "Mechanoregulation of leading edge PKA activity during ovarian cancer cell migration." ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/273.

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Ovarian cancer is the deadliest of all the gynecologic cancers and is known for its clinically occult and asymptomatic dissemination. Most ovarian malignancies are diagnosed in the late stages of the disease and the high rate of morbidity is thought to be due, in part, to the highly metastatic nature of ovarian carcinomas. Cancer metastasis relies on the ability of cells to migrate away from primary tumors and invade into target tissues. Though the processes are distinct, cancer cell invasion relies on the underlying migration machinery to invade target tissues. Cell migration requires the coo

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15

Devabhakthuni, Rajeswari. "Differential expression of germ cell nuclear factor (GCNF) in human ovarian cancer cell lines." Thesis, Wichita State University, 2010. http://hdl.handle.net/10057/3302.

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Germ Cell Nuclear Factor (GCNF) is the only existing member of nuclear receptor (NR) super family NR6A1, and an orphan receptor because of an unidentified ligand. Members of NR superfamily act as ligand activated transcription factors which regulate the target gene expression either by activating or repressing transcriptional activity. GCNF is expressed in both embryonic and adult stages in the human. In adults, expression of GCNF is restricted to testis and ovaries. GCNF is also found in other species such as Xenopus leavis, Zebrafish, rats, mice and hamsters. GCNF mRNA and protein were recen

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16

Karakji, Eli Gabriel. "Regulation of the rat ovarian plasminogen activator system during follicular development." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/10314.

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Successful ovarian follicular growth and ovulation require controlled and directional proteolytic activity for cell migration and follicular wall rapture. Plasminogen activator (PA) system is known to be involved in tissue remodelling during various physiologic and pathologic processes. PA system comprises two activators (tissue-type, tPA and urokinase-type, uPA), three inhibitors (PAI-1, PAI-2 and protein nexin-I) and one receptor (uPAR). In vivo expression of the PA system during follicular development was studied in the immature female rat. Whereas tPA, PAI and uPAR mRNA expression and prot

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17

Boone, David L. "The role and regulation of deoxyribonuclease I in rat ovarian apoptosis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq26106.pdf.

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18

Gounaris, Ioannis. "Functional characterisation of driver events in ovarian clear cell carcinoma." Thesis, University of Cambridge, 2014. https://www.repository.cam.ac.uk/handle/1810/246465.

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Ovarian clear cell carcinoma (OCCC) is a distinct subtype of epithelial ovarian cancer (EOC) characterised by glycogen accumulation. Frequently arising within endometriotic cysts, it can be conceived as an ectopic endometrial cancer. Putative driver genomic events include HNF1B overexpression and inactivating ARID1A mutations. Importantly, these can also be found in a significant proportion of adjacent non-malignant endometriotic lesions and, therefore, are likely early events in OCCC pathogenesis. I hypothesised that the study of the functional consequences of these driver genomic events and

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19

Vuong, Nhung. "Molecular Mechanisms by Which Estrogen Causes Ovarian Epithelial Cell Dysplasia." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37286.

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The initiating events of ovarian cancer remain unknown, but an established risk factor is use of estrogen therapy by post-menopausal women where there is a positive correlation between duration of use and risk for disease. Mouse models of ovarian cancer have shown that exposure to exogenous 17β-estradiol (E2) accelerates tumour onset so this study aims to investigate the E2 signalling mechanisms responsible for sensitizing ovarian epithelial cells to transformation. By developing model systems that are responsive to E2 manipulation, we showed that E2 induces the formation of epithelial dysplas

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20

Sinclair, J. R. "Proteomic analysis of cell models of ovarian cancer tumour suppression." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19512/.

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Epithelial ovarian cancer (EOC) is the most common form of gynaecological malignancy in the developed world. Identifying molecular markers of disease may provide novel approaches to screening and could enable targeted treatment and the design of novel therapies. In previous work, 141 primary ovarian tumours were analysed using metaphase comparative genomic hybridization to identify complete or partial chromosome deletions that may harbour tumour and/or metastasis suppressor genes. Chromosome 18 (Ch18) was found to have deletions in 50% of the tumours. Microcell-mediated chromosome transfer (MM

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21

Anderson, Nicole Shree. "The Roles of Elevated Bcl-2 in Ovarian Cancer." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/6161.

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Ovarian cancer (OC) is the second most common gynecologic cancer; however it is responsible for the most gynecologic cancer-related deaths. Apoptosis evasion is an important mechanism in OC tumorigenesis, and the prototypic anti-apoptotic protein, B-cell lymphoma 2 (Bcl-2), is often overexpressed in OC tumors. Gaining a better understanding of the mechanism(s) behind Bcl-2 overexpression and potential extra-anti-apoptotic functions of Bcl-2 could elucidate the importance of elevated Bcl-2 in OC. In the current study, I show through immunohistochemical analysis of normal, benign, and OC tissue

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22

Tang, Chi-man Terence. "Identification of a minimal overlapping amplified region (MAR) at 19q13.1-13.2 in four ovarian cancer cell lines." Click to view the E-thesis via HKUTO, 2001. http://sunzi.lib.hku.hk/hkuto/record/B42576532.

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23

Cheng, Jung-Chien. "Role of E-cadherin in the serous borderline ovarian tumor and low-grade serous ovarian carcinoma cell invasion." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43651.

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E-cadherin is a membrane glycoprotein located at cell adherens junctions. A switch from E-cadherin to N-cadherin expression has been considered a hallmark of the epithelial-mesenchymal transition (EMT), which is primarily due to the up-regulation of the transcription factors Snail, Slug, Twist and ZEB1. Epithelial ovarian cancer cells with low E-cadherin expression are more invasive, and the absence of E-cadherin expression in ovarian cancer is associated with poor prognosis and survival. Serous borderline ovarian tumors (SBOT) are slow-growing, non-invasive ovarian epithelial neoplasms. SBOT

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24

Rajapaksha, W. R. A. K. J. S. "Changes in gene expression during bovine granulosa cell luteinization." Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266187.

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25

Amano, Yasuaki. "Metabolic alterations caused by HNF1β expression in ovarian clear cell carcinoma contribute to cell survival". Kyoto University, 2016. http://hdl.handle.net/2433/215417.

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26

Ahmad, Omaima Farid. "The Role of Filamin A in Cell Motility, Adhesion and Invasion in Ovarian Cancer Cells." University of Toledo Honors Theses / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=uthonors1503407822068426.

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27

Chung, Chin-man, and 鍾展雯. "Involvement of chromosome 20q in the immortalization of human ovarian surface epithelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971672.

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28

Lee, Yau-fai, and 李有輝. "Plexin-B1 and semaphorin 4D in ovarian cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44668508.

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29

Koskela, S. (Sanna). "Granulosa cell anti-Müllerian hormone secretion in ovarian development and disease." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526202853.

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Abstract Anti-Müllerian hormone (AMH) was identified originally in connection with its role in male sexual differentiation. In females, AMH is secreted by ovarian granulosa cells of growing follicles and its serum levels correlate well with the remaining number of follicles, thus reflecting ovarian reserve. The aim of this study was to explore the expression and secretion of AMH in human ovarian development and in various disorders resulting in decreased reproductive function. In fetal ovaries, AMH expression was found to be initiated at midgestation and it increased gradually towards term. In

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30

Brown, Yvonne A. R. "Regulation of ovarian function by the germ cell specific DAZL gene." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4844.

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The RNA binding protein DAZL (Deleted in Azoospermia) is essential for germ cell survival and subsequent fertility. The transgenic mouse DAZL model has confirmed that knockout (KO) females are infertile as a direct consequence of complete postnatal oocyte ablation. Interestingly, the heterozygous (Het) DAZL females have increased fertility giving rise to significantly more viable offspring, accompanied by significantly reduced plasma FSH and increased inhibin B compared to levels observed in the wildtype (Wt) females. Recent studies to identify putative DAZL mRNA targets suggest that DAZL may

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31

Cranston, Aaron-Neill. "Genetic analysis of chromosome 17 in ovarian tumours and cell lines." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318882.

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32

Brankin, Victoria. "Porcine oocyte secreted factors and somatic ovarian cell growth and function." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395710.

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33

Tsang, Hiu-may, and 曾嬈媚. "Folate receptor alpha and reduced folate carrier in ovarian cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4467059X.

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34

Walsh, Peter. "BMP9 signalling in ovarian cancer." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/edf86461-ad32-4e60-8bf0-9112913e75ef.

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Ovarian Cancer is the 5th most common cause of cancer death in women and the second most common gynaecological cancer in the UK. Worldwide, around 152,000 women were estimated to have died from ovarian cancer in 2012. Survival rates for women with epithelial ovarian cancer have not significantly changed since platinum-based treatment was introduced over 30 years ago. This is particularly disconcerting considering the fact that there is a less than 5% five year survival rate for patients diagnosed with late stage high grade serous ovarian cancer. This thesis examines the role of BMP signalling

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35

Latimer, John Alexander. "Gonadotrophins and cytokines in ovarian epithelial cancer /." Title page, table of contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09MD/09mdl357.pdf.

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36

Catterall, J. B. "The role of hyaluronic acid and CD44 in ovarian tumour cell adhesion." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361558.

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37

TIERNO, DOMENICO. "Comprehensive Characterization and Effective Combinatorial Targeting of Epithelial Ovarian Cancer and High-Grade Serous Ovarian Cancer via Single-cell Analysis." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2996074.

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Ovarian cancer kills more than 40 000 women in Europe and more than 150 000 women globally each year. The epithelial ovarian cancer (EOC) is the most common subtype and encompasses a collection of neoplasms with distinct clinical-pathological, molecular features and prognosis; among them the most common are the clear cells (CCOC), the mucinous (MOC), the endometrioid (ENOC), the low grade serous (LGSOC) and the high grade serous ovarian cancer (HGSOC). The HGSOC, in particular, is the most deadly form of EOC due to its high intratumor heterogeneity and lack of early diagnosis. The mechanical p

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38

Brachova, Pavla. "Oncomorphic Tp53 mutations in advanced serous ovarian carcinomas." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/4581.

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The tumor suppressor gene TP53 sits at the crux of response to cellular stresses. This is the most frequently inactivated gene in human tumors, being the target of somatic mutations. The protein product of TP53 is p53, and plays a crucial role in anti-proliferative signals through the induction of apoptosis, senescence, and cell-cycle arrest when activated by stresses such as genotoxic chemotherapeutic drugs. Therefore, the status of TP53 mutation in a tumor has profound implications for the tumorigenic potential as well as the response to anti-cancer therapies. Indeed, numerous studies have s

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39

Iness, Audra N. "Mechanisms of B-Myb oncogenicity in ovarian cancer." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5681.

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High expression of B-Myb (encoded by MYBL2), an oncogenic transcription factor, is associated with cell cycle deregulation and poor prognosis in several cancers, including ovarian cancer. However, the mechanism by which B-Myb alters the cell cycle is not fully understood. In proliferating cells, B-Myb interacts with the MuvB core complex including LIN9, LIN37, LIN52, RBBP4, and LIN54, forming the MMB (Myb-MuvB) complex, and promotes transcription of genes required for mitosis. Alternatively, the MuvB core interacts with Rb-like protein p130 and E2F4-DP1 to form the DREAM complex that mediates

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40

鄧致文 and Chi-man Terence Tang. "Identification of a minimal overlapping amplified region (MAR) at 19q13.1-13.2 in four ovarian cancer cell lines." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B42576532.

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Böpple, Kathrin [Verfasser], and Roland [Akademischer Betreuer] Kontermann. "Characterization of persister-cell derived ovarian cancer cells and methods for advanced 3D cell and tissue culture / Kathrin Böpple ; Betreuer: Roland Kontermann." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2021. http://d-nb.info/1233287818/34.

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42

Li, Julang. "Role and regulation of prostaglandin production in granulosa cell DNA synthesis during ovarian follicular development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq26131.pdf.

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43

Noubani, Alfred. "B-type natriuretic peptide receptor expression and activity is hormonally regulated in rat ovarian cells." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33432.

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Natriuretic peptides form a family of structurally-related peptides known to regulate salt and water homeostasis and to cause vasodilation. Synthesis of atrial (ANP), brain (BNP), and C-type (CNP) natriuretic peptides occurs mainly in the heart and brain and has been identified recently in the female reproductive tract. The expression of ANP and CNP, as well as their cognate guanylyl cyclase receptors (NPR-A and NPR-B, respectively), have been detected in the rat ovary.<br>We have shown previously that the expression of the natriuretic peptides and their receptors, in the rat ovary, is modulat

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Roberts, April M. "Steroid hormone treatments alter growth characteristics in transformed human ovarian cell lines." Virtual Press, 2003. http://liblink.bsu.edu/uhtbin/catkey/1265095.

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Dougherty, Sarah Louise. "The Role of the Cytokine CSF-1 in Ovarian Tumor Cell Motility." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146023.

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Ovarian cancer is a leading cause of death in women because it?s late presentation and aggressive metastasis result in a poor prognosis. The CSF-1 ligand and its receptor cfms have been linked to the motility and invasion of cells in both normal and cancerous environments. The purpose of this study is to understand the role that CSF-1 plays in mediating motility in ovarian cancer cells. CSF-1 was knocked-down in Hey and SKOV3 ovarian cancer lines by the transfection of anti-CSF-1 shRNA. A transwell migration assay was then used to visualize and quantify changes in cell motility. Both cell line

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CAPUA, G. DI. "CHARACTERIZATION OF HUMAN TENEURIN-4 TRANSCRIPT IN OVARIAN CANCER DERIVED CELL LINES." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/171959.

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Teneurins are transmembrane glycoproteins encoded by ODZ genes. Teneurins are a unique protein family conserved from flies and worms to human and are mainly expressed in the developing and adult nervous system where they are thought to be crucial for neurogenesis and axon-guidance. Teneurins are also expressed outside CNS where they have been proposed to play a role in morphogenesis and cell migration. Vertebrate teneurin expression pattern has been studied most extensively in mice and chicken, however still very little is known about their biological function and mechanism of action in humans

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47

Prieske, Katharina [Verfasser], Henning [Akademischer Betreuer] Walczak, Claudia [Akademischer Betreuer] Binder, and Steven [Akademischer Betreuer] Johnsen. "Investigation of TRAIL resistance in ovarian cancer cell lines and translational application in primary ovarian cancer cells / Katharina Haider. Gutachter: Claudia Binder ; Steven Johnsen. Betreuer: Henning Walczak." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2011. http://d-nb.info/104273268X/34.

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48

Falcone, Emilia Liana. "Ovarian cancer cells exhibit aberrations in the Wnt signaling pathway, which affect cell proliferation and cadherin expression." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101121.

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Ovarian cancer is the leading cause of death from a gynecological malignancy in North America. It is an incomplete understanding of the early molecular events in ovarian carcinogenesis which limit our ability to diagnose and effectively treat this disease at a stage when it is still curable. The Wnt/beta-catenin canonical signaling pathway is involved in development, wound repair, and tumorigenesis. Studies examining the involvement of Wnt/canonical signaling in ovarian carcinogenesis, however, have only recently begun to emerge. In this study, we hypothesize that ovarian cancer cells exhibit

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Boulay, Hillary Michelle. "The effect of cisplatin on the role of proprotein convertases (PCs) in human ovarian cancer cells." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27319.

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Proprotein convertases (PCs) have been implicated in cancer progression as well as cell survival, although their role in ovarian cancer and drug sensitivity is largely unknown. Of all the PCs, PC4 has the most restricted expression; present only in reproductive tissues (testis, ovary and placenta). The expression and regulation of PC4 were investigated using a pair of cisplatin-sensitive and -resistant cell lines as an in vitro model of ovarian cancer. PC4 is expressed in the ovarian cancer cell lines as well as in tumours from patients diagnosed with the disease. Over-expression of PC4 in ch

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Illuzzi, G. "SPHINGOLIPID METABOLISM'S ALTERATIONS CORRELATED WITH TUMOR CELL INVASIVITY AND FENRETINIDE RESISTANCE IN A HUMAN OVARIAN CARCINOMA CELL LINE." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/160742.

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Glycosphingolipids (GSL) modulate several signal transduction processes controlling cell proliferation, survival, differentiation and transformation. Alterations in the expression of carbohydrate epitopes associated with GSL are frequent in tumors, and it has been hypothesized that GSL could play important roles in modulating some of the properties of tumor cells. The contribution of transformation-associated changes in GSL composition to the tumor phenotype are very complex and not fully elucidated, and likely implies heterogeneous molecular mechanisms. However, at least two well established

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