Relevant bibliographies by topics / Ovarian Follicular Development

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Ovarian Follicular Development'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Ovarian Follicular Development.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Ovarian Follicular Development"

1

Leung, Peter C. K. "Ovarian follicular development and regression." Canadian Journal of Physiology and Pharmacology 67, no. 8 (August 1, 1989): 953. http://dx.doi.org/10.1139/y89-149.

Full text
Abstract:
Many exciting developments in mammalian reproductive research with far-reaching consequences have occurred in recent years. To highlight the significance of some of these developments, a symposium on the theme of ovarian follicular development and regression was organized, and held at the joint meeting of the American Physiological Society and the Canadian Physiological Society, in Montréal in October 1988. Several leading researchers, from both Canada and the U.S.A., in various aspects of ovarian research, participated in the symposium. The topics of discussion ranged from the role of growth factors and novel intraovarian regulators during follicular development, to molecular aspects of ovarian hormone production, to the functional regression of the corpus luteum. It is expected that the following proceedings will serve as a reference for researchers concerned with reproductive endocrinology as well as providing a foundation for future collaborative study.
APA, Harvard, Vancouver, ISO, and other styles
2

Sobinoff, A. P., V. Pye, B. Nixon, S. D. Roman, and E. A. McLaughlin. "153. XENOBIOTICS; INFLUENCE ON OVARIAN FOLLICULAR DEVELOPMENT." Reproduction, Fertility and Development 21, no. 9 (2009): 71. http://dx.doi.org/10.1071/srb09abs153.

Full text
Abstract:
The mammalian female reproductive lifespan is largely defined by a finite pool of ovarian follicles established around the time of birth. It is now understood that certain synthetic chemical compounds, known as xenobiotics, can cause premature ovarian senescence through the destruction of small ovarian follicles. Although the ovotoxic effects of these chemicals are well documented, the exact molecular mechanisms behind their action are only just becoming understood. Recent evidence suggests that bioactivation of xenobiotics by Phase I detoxifying enzymes may lead to the generation of free oxygen radicals (ROS), which we suspect may perturb intracellular signalling pathways in primordial follicles. In this study we attempted to identify ovarian follicle signalling pathways activated by xenobiotic exposure using ovotoxic agents which target immature follicles. Neonatal ovaries obtained from 3/4-day old Swiss mice were exposed to either 4-Vinylcyclohexene (25µM), Methoxychlor (25µM) or Menadione (5µM) for 96hrs using our in vitro culture system. Total RNA was then collected and analysed using Affymetrix Mouse Genome 430 2.0 Arrays. Bioinformatic analysis identified between ~500–1000 genes with a two-fold significant difference in gene expression (p<0.05) for each xenobiotic compared to the control. Differentially expressed genes were analysed for pathways and molecular functions using Ingenuity Pathways Analysis (Ingenuity Systems). In agreement with the current literature, many of the genes belonged to toxic response pathways, such as; Xenobiotic metabolism (10); p53 (15) and Apoptosis (11) signalling. However, the vast majority of the differentially expressed genes belonged to canonical pathways implicated in follicular development, such as PI3K/AKT (18), Wnt/ b -catenin (21), and JAK/Stat (8) signalling. Further qPCR analysis has confirmed a substantial increase in the transcription factor Sox4 and cell cycle inhibitor Cdkn2a in 4-Vinylcyclohexene and Menadione treated ovaries respectively. These results suggest that xenobiotics which target primordial follicles may exert part of their ovotoxic effects by perturbing signalling pathways involved in follicular activation and development.
APA, Harvard, Vancouver, ISO, and other styles
3

Segino, Miwa, Mario Ikeda, Fumiki Hirahara, and Kahei Sato. "In vitro follicular development of cryopreserved mouse ovarian tissue." Reproduction 130, no. 2 (August 2005): 187–92. http://dx.doi.org/10.1530/rep.1.00515.

Full text
Abstract:
In a previous report, we showed that follicles isolated from frozen/thawed mouse ovarian tissues reached the mature follicle stage on the 12th day of culture. However, the developmental ability was lower than that of fresh ovarian tissue. The purpose of this study was to define a culture system with some technical modification for preantral follicles isolated from frozen/thawed ovarian tissue and to confirm cell injury. Ovaries obtained from three-week-old female mice were cryopreserved by the rapid freezing method. Preantral follicles isolated from frozen/thawed ovarian tissues were cultured for 12–16 days. The follicles were then stimulated with human chorionic gonadotropin. In vitro fertilization was performed on the released cumulus–oocyte complexes (COCs). Preantral follicle viability was assessed by supravital staining using Hoechst 33258. Using this stain cell death was found in part of the granulosa cells of a follicle obtained from frozen/thawed ovarian tissue. On the 14th and 16th days of culture, the diameters of follicles isolated from frozen/thawed ovaries were larger than on the 12th day of culture. The released COCs were fertilized and developed to the blastocyst stage in 15.8% (12/76) of the oocytes taken from the fresh group, and in 0% (0/73), 2.9% (2/69) and 19.1% (22/115) of the oocytes taken from the frozen/thawed group that had been cultured for 12, 14 and 16 days respectively. The preantral follicles isolated from frozen/thawed mouse ovarian tissues developed slowly compared with the freshly prepared preantral follicles. During prolonged culture from 12 to 16 days, these follicles obtained the potential to fertilize and develop to the blastocyst stage.
APA, Harvard, Vancouver, ISO, and other styles
4

van der Schoot, P., and W. J. de Greef. "Development of ovarian follicles during lactation in rats." Acta Endocrinologica 112, no. 2 (June 1986): 247–52. http://dx.doi.org/10.1530/acta.0.1120247.

Full text
Abstract:
Abstract. Ovarian follicular development was studied during lactation in rats. At an early stage of lactation (day 7) the ovaries showed only small follicles in agreement with the expected 'follicular quiescence' during lactation. However, at a more advanced stage of lactation (day 14), there were large follicles which were capable of ovulation in response to exogenous gonadotropins. Unilateral ovariectomy early during lactation (day 2) resulted in compensatory follicular development in the remaining ovary. However, doubling of the number of large follicles per ovary had not yet occurred by day 13. Unilateral ovariectomy caused a significant prolongation of the delay of embryonic implantation in pregnant lactating rats: this probably reflected delay of the development of sufficiently large numbers of oestrogen-producing follicles for this process. Unilateral ovariectomy did not affect the length of lactational pseudopregnancy. The findings indicate that 'follicular quiescence' during lactation in rats is limited to the very first period after parturition. This limitation may result from the relative ineffectiveness of suckling to suppress the secretion of FSH. In this respect, ovarian follicular development in rats differs from that in many other species, including primates and man.
APA, Harvard, Vancouver, ISO, and other styles
5

Kim, Yu Jin, YoungJoon Park, Yeo Reum Park, Young Sang Kim, Hye Ran Lee, Sang Jin Lee, Myung Joo Kim, KyuBum Kwack, Jung Jae Ko, and Jae Ho Lee. "Role of RGMc as a Neogenin Ligand in Follicular Development in the Ovary." Biomedicines 9, no. 3 (March 10, 2021): 280. http://dx.doi.org/10.3390/biomedicines9030280.

Full text
Abstract:
There is currently no cure for infertility in women with a poor ovarian response (POR). Neogenin is reported to be abundantly expressed in the ovary; however, its role in mammalian follicular development is unclear and its ligand and signaling pathway remain uncertain. We systematically investigated the role of neogenin and the ligand repulsive guidance molecule c (RGMc) during follicular development. We treated hyperstimulated mouse ovaries with RGMc and analyzed follicular development. Furthermore, we investigated clusters of up/downregulated genes in RGMc-treated ovaries using whole-transcriptome next-generation sequencing (NGS). In addition, we investigated whether expression of up/downregulated factors identified by NGS was also altered in cumulus cells (CCs) of patients with a POR. The number of oocytes was 40% higher in RGMc-treated ovaries than in control ovaries. NGS data indicated that prostaglandin D2 (PGD2) was involved in the RGMc signaling pathway during follicular development. RGMc treatment significantly elevated the PGD2 level in culture medium of CCs obtained from patients with a POR. Our results demonstrate that RGMc as neogenin ligand promotes follicular development in ovaries via the PGD2 signaling pathway. Therefore, it may be possible to use RGMc for ovarian stimulation in patients with a POR.
APA, Harvard, Vancouver, ISO, and other styles
6

Rodgers, R. J., T. C. Lavranos, I. L. van Wezel, and H. F. Irving-Rodgers. "Development of the ovarian follicular epithelium." Molecular and Cellular Endocrinology 151, no. 1-2 (May 1999): 171–79. http://dx.doi.org/10.1016/s0303-7207(99)00087-8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Maddineni, Sreenivasa R., Olga M. Ocón-Grove, Susan M. Krzysik-Walker, Gilbert L. Hendricks, and Ramesh Ramachandran. "Gonadotropin-inhibitory hormone (GnIH) receptor gene is expressed in the chicken ovary: potential role of GnIH in follicular maturation." REPRODUCTION 135, no. 2 (February 2008): 267–74. http://dx.doi.org/10.1530/rep-07-0369.

Full text
Abstract:
Gonadotropin-inhibitory hormone (GnIH), an RFamide peptide, has been found to inhibit pituitary LH secretion in avian and mammalian species. The gene encoding a putative receptor for GnIH (GnIHR) was recently identified in the chicken and Japanese quail brain and pituitary gland. GnIHR appears to be a seven-transmembrane protein belonging to a family of G-protein-coupled receptors. In the present study, we have characterized the expression of GnIHR mRNA in the chicken ovary and demonstrate that GnIHR may exert an inhibitory effect on ovarian follicular development. By RT-PCR, we detected GnIHR mRNA in the chicken testis and in the ovary, specifically both thecal and granulosa cell layers. Real-time quantitative PCR analysis revealed greater GnIHR mRNA quantity in theca cells of prehierarchial follicles compared with that of preovulatory follicles. GnIHR mRNA quantity was significantly decreased in sexually mature chicken ovaries versus ovaries of sexually immature chickens. Estradiol (E2) and/or progesterone (P4) treatment of sexually immature chickens significantly decreased ovarian GnIHR mRNA abundance. Treatment of prehierarchial follicular granulosa cellsin vitrowith chicken GnIH peptide significantly decreased basal but not FSH-stimulated cellular viability. Collectively, our results indicate that the ovarian GnIHR is likely to be involved in ovarian follicular development. A decrease in ovarian GnIHR mRNA abundance due to sexual maturation or by E2and/or P4treatment would implicate an inhibitory role for GnIHR in ovarian follicular development. Furthermore, GnIH may affect follicular maturation by decreasing the viability of prehierarchial follicular granulosa cells through binding to GnIHR.
APA, Harvard, Vancouver, ISO, and other styles
8

Cha, KY, BR Do, HJ Chi, TK Yoon, DH Choi, JJ Koo, and JJ Ko. "Viability of Human Follicular Oocytes Collected from Unstimulated Ovaries and Matured and Fertilized in vitro." Reproduction, Fertility and Development 4, no. 6 (1992): 695. http://dx.doi.org/10.1071/rd9920695.

Full text
Abstract:
Immature human follicular oocytes were collected from unstimulated ovaries, matured and fertilized in vitro and then transferred to patients with no ovarian dysfunction such as premature ovarian failure. From 11 1 consenting donors, 422 immature oocytes were collected from 97 ovaries between January 1990 and October 1991. The number of oocytes collected from ovaries and their development were recorded so that comparisons could be made among donors of different ages and ovarian condition, such as menstrual cycle, cyclic and non-cyclic ovaries. The rate of fertilization in vitro showed a peak in the 31-40-year age group; however, there was no statistical difference in the rate of oocyte maturation and cleavage among the donors in the different age groups. Immature oocytes of the luted phase had a significantly higher maturation rate than those of the follicular phase. There was no significant difference in the number of recovered oocytes, or in the development of immature follicular oocytes, between cyclic and non-cyclic ovaries. Mature follicular fluid and peritoneal fluid had a significant effect on the development of immature follicular oocytes. Also, it was found that fertilized eggs cleaved more frequently in the medium containing hypoxanthine compared with the medium without hypoxanthine. Finally, from 21 transfer cycles, viable embryos were derived from immature follicular oocytes, resulting in two pregnancies, both leading to the birth of normal babies. These findings suggest that culture in vitro of immature follicular oocytes, from unstimulated ovaries, to a suitable condition, could be used optimally for clinical applications such as human ovum donation programmes.
APA, Harvard, Vancouver, ISO, and other styles
9

Shi, Xuan, Tao Tang, Qiyuan Lin, Hongbo Liu, Yufeng Qin, Xinyu Liang, Peiqing Cong, et al. "Efficient generation of bone morphogenetic protein 15-edited Yorkshire pigs using CRISPR/Cas9†." Biology of Reproduction 103, no. 5 (August 6, 2020): 1054–68. http://dx.doi.org/10.1093/biolre/ioaa138.

Full text
Abstract:
Abstract Bone morphogenetic protein 15 (BMP15), a member of the transforming growth factor beta superfamily, plays an essential role in ovarian follicular development in mono-ovulatory mammalian species. Studies using a biallelic knockout mouse model revealed that BMP15 potentially has just a minimal impact on female fertility and ovarian follicular development in polyovulatory species. In contrast, our previous study demonstrated that in vivo knockdown of BMP15 significantly affected porcine female fertility, as evidenced by the dysplastic ovaries containing significantly decreased numbers of follicles and an increased number of abnormal follicles. This finding implied that BMP15 plays an important role in the regulation of female fertility and ovarian follicular development in polyovulatory species. To further investigate the regulatory role of BMP15 in porcine ovarian and follicular development, here, we describe the efficient generation of BMP15-edited Yorkshire pigs using CRISPR/Cas9. Using artificial insemination experiments, we found that the biallelically edited gilts were all infertile, regardless of different genotypes. One monoallelically edited gilt #4 (Δ66 bp/WT) was fertile and could deliver offspring with a litter size comparable to that of wild-type gilts. Further analysis established that the infertility of biallelically edited gilts was caused by the arrest of follicular development at preantral stages, with formation of numerous structurally abnormal follicles, resulting in streaky ovaries and the absence of obvious estrous cycles. Our results strongly suggest that the role of BMP15 in nonrodent polyovulatory species may be as important as that in mono-ovulatory species.
APA, Harvard, Vancouver, ISO, and other styles
10

Zhou, Jiawei, Xianwen Peng, and Shuqi Mei. "Autophagy in Ovarian Follicular Development and Atresia." International Journal of Biological Sciences 15, no. 4 (2019): 726–37. http://dx.doi.org/10.7150/ijbs.30369.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Ovarian Follicular Development"

1

Telfer, Evelyn Elizabeth. "Factors influencing follicular development in mammalian ovaries." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/26993.

Full text
Abstract:
The studies described in this thesis have been concerned with several aspects of follicular development in the mammalian ovary. Chapters 2, 3 6 4 deal with mathematical modelling of ovarian follicle dynamics in normal animals and comparisons with experimentally manipulated animals. Chapter 5 describes a novel aethod for estimating the clonal origin of the mouse ovarian follicle. In the final two chapters, the comparative physiology and anatomy of follicular numbers and sizes and the incidence of polyovular follicles are described for a number of species. The unifying theme of these studies is that they reveal patterns existing in follicular development and utllisation by detailed examination of one species, (CBA/ca mouse), and broadly by interspeci,fic comparisons (with relation to scaling). A detailed mathematical description of the follicular dynamics of virgin CBA/ca mice up to 98 days of age has been obtained by the application of compartmental modelling to differential follicle counts. The rates of follicle growth (migration) and death have been estimated for five ?stages of development (primordial to Graafian). The model predicts age changes in follicle growth and death rate, there being transitions in the parameters at 20 days second at 60 days. The parameters for normal animals have been compared with those of anilllals under two experimental conditions: 1) by unilateral ovariectomy at 4-2 days of age, which abruptly halves the numbers of ovarian follicles and alters the ratio of large : small follicles. 2) by blocking ovulation using progesterone implants. The dynamics of follicle growth were altered by both treatments in comparison with the controls. Follicles at all stages of development were affected by unilateral ovariectomy and differences may exist with time. The compensatory response by the remaining ovary was due to a combination of an increased preantral growth rate and a decrease in atresia at antral stages. Earlier stages of follicle development were affected this may have been incidental to the compensatory response. In progesterone treated animals follicles developed through to antral stages when they un~erwent atresia. The effects of treatment were observed at three levels of development: 1) The initiation of growth from the primordial pool, 2) Growth rate of small follicles and 3) deaths at larger stages of follicular development. Longer term observations indicated that these effects may not be constant. The modelling studies have looked at numerical changes in the follicle population with time but a greater understanding of the develomental biology of the follicle is required in order to explain the changes in growth and death rates observed. This problem has been tackled initially by studying the clonal origin of the follicular epithelium. The technique used is based on the principle that cells in females. are generally mosaic as a result of X-chromosome inactivation the use of X linked cell markers phospho-glycerate kinase-1 (PGK-1). Granulosa cells were found to be polyclonal in origin with the number of progenitor cells numbering 5 on average. Analysis of cumulus and mural granulosa cells showed that substantial cell mixing had occurred and cuaulus cells were generally founded by more than one clone. Finally, comparative studies have been conducted to look at scaling of follicle sizes and numbers and of polyovular follicles. Ovarian follicle and oocyte sizes were scaled according to body weight (ranging from .005-500Kg) using data from 22 species. Primordial and Graafian follicle sizes varied with body weight but closer correlations for the latter were obtained when the sum of the surface areas or volUiles for a preovulatory set were considered as opposed to the values for individual follicles. The numbers of nongrowtng follicles 1n reserve at young adult ages were correlated with maximum longevity of the species and related to body weight. The frequency of polyov~lar follicles varied 1n species studied and were most abundant 1n the domestic bitch. The overall incidence of polyovular folUcles 1n young bitches was 14 S, being reduced to 5~ 1n bitches at 7-11 years. The frequency of the various types of polyovular preantral folUcle varied inversely with the numbers of oocytes per follicle.
APA, Harvard, Vancouver, ISO, and other styles
2

Burke, Christopher R. "Regulation of Ovarian Follicular Development with Estradiol in Cattle." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1054666226.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Soboloff, Jonathan. "Regulation of hen granulosa cell fate during ovarian follicular development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0012/NQ38799.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Sontakke, Sadanand Dewaji. "Identification and characterisation of microRNAs during bovine ovarian follicular development." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/17963.

Full text
Abstract:
Proper understanding of ovarian follicular and luteal development is essential to improve and optimally control reproductive function in domestic animals and to unravel causes of infertility in animals and humans. MicroRNAs (miRNAs) are key post-transcriptional gene regulators in multiple processes involving tissue growth and differentiation. The studies in this thesis were carried out to identify and characterise expression profiles of miRNAs and their potential roles during ovarian follicular development in the cow. The first study aimed to identify expression profiles of miRNAs during antral follicle growth. Follicles were collected from abattoir ovaries and their status (healthy/atretic) was assessed by measuring steroid levels and aromatase expression. An heterologous microarray approach followed by RT-qPCR validation was used to identify and compare miRNA profiles between large (13–16 mm) healthy and small (4–8 mm) follicles. A unique subset of 7 miRNAs (miR-144, miR-202, miR-210, miR-451, miR-652, miR-873 and miR-876) was identified that were enriched in the Large Healthy follicles relative to small follicles and Large Atretic follicles. Further characterisation revealed that many of these miRNAs were highly expressed in the granulosa compartment of the follicle, predominantly in the mural granulosa cells, indicating their potential involvement in regulating granulosa cell function. Expression patterns of miRNAs in the ovarian tissues were generally reflected in the follicular fluid, thus follicular fluid may be used to monitor follicular health. Finally, tissue-wide screening of miRNAs identified miR-202 as a gonad-specific miRNA in the cow. The aim of the second study was to identify potential roles of the miRNAs enriched in Large Healthy follicles. Using in silico approaches, about 1700 bovine genes were identified as the predicted targets of those miRNAs. Putatively targeted signalling pathways are primarily involved in cell survival, proliferation and differentiation. Further, as expected, top predicted gene targets (SPRED1, ATG7, TGFBR2) showed an expression pattern in follicular tissues that was opposite to the patterns of the targeting miRNAs. However, expression patterns of miR-202 or miR-210 during follicular growth could not be recapitulated in gonadotrophin-stimulated cells in vitro and moreover, over-expression or inhibition of miR-202 in these cells did not result in changes in target mRNA levels. The third study investigated the expression profiles of miRNAs during follicle-luteal transition. Microarray analyses identified 9 miRNAs that were upregulated and 14 miRNAs that were downregulated between Large Healthy follicles and early corpus luteum in the cow. Predicted targets of these miRNAs were associated with signalling pathways involved in cell survival, proliferation and differentiation, indicating that these miRNAs might play significant regulatory roles during ovulation and early luteal development. Further, expression of some of these miRNAs and their putative targets during luteinisation in vivo could be recapitulated in cultured granulosa cells providing a system to study the functional roles of these miRNAs during follicle-luteal development. In summary, this is the first study identifying unique subsets of miRNAs associated with follicular development and the follicle-luteal transition in the cow which may be important for female fertility.
APA, Harvard, Vancouver, ISO, and other styles
5

Karakji, Eli Gabriel. "Regulation of the rat ovarian plasminogen activator system during follicular development." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/10314.

Full text
Abstract:
Successful ovarian follicular growth and ovulation require controlled and directional proteolytic activity for cell migration and follicular wall rapture. Plasminogen activator (PA) system is known to be involved in tissue remodelling during various physiologic and pathologic processes. PA system comprises two activators (tissue-type, tPA and urokinase-type, uPA), three inhibitors (PAI-1, PAI-2 and protein nexin-I) and one receptor (uPAR). In vivo expression of the PA system during follicular development was studied in the immature female rat. Whereas tPA, PAI and uPAR mRNA expression and protein distribution increased in both granulosa and theca-interstitial layers during follicular maturation and reached maximum levels during the preovulatory period, the opposite was true for uPA. Urokinase PA was highly expressed at early stage of development and markedly decreased prior to the expected time of ovulation. Net secreted PA (PAs) and cell associated PA (PAc) activities were higher in differentiated cells and PAs accounted for 70-80% of the total PA activity in both cell stages of follicular development. Our results suggest that (1) a coordinated expression of ovarian PA system exists during follicular development when granulosa cells undergo transformation from undifferentiated and proliferatively active cells to highly differentiated but mitogenically relatively quiescent ones, and (2) in addition to gonadotropins, several intra-ovarian factors play an important role in the regulation of the ovarian PA system during follicular development. (Abstract shortened by UMI.)
APA, Harvard, Vancouver, ISO, and other styles
6

Wang, Qi. "Chemerin and Prohibitin in the Regulation of Ovarian Follicular Development and their Potential Involvement in Polycystic Ovarian Syndrome." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24098.

Full text
Abstract:
Follicular growth and maturation are tightly regulated processes, which involve the participation of endocrine, autocrineparacrine factors and intracellular molecules. Due to the numerous research efforts, a large number of regulators and their mechanisms of regulation of follicular growth and differentiation have been established. Although the abnormal expression and activities of some of these regulators are believed to be associated with ovarian dysfunction diseases, such as polycystic ovarian syndrome (PCOS), the etiology and pathogenesis of this syndrome are not completely understood. In this thesis, we have identified two novel regulators of follicular growth and differentiation and examined the cellular and molecular mechanisms that contribute to the folliculogenesis. We present here that chemerin reduces FSH-induced steroidogenic enzyme expression and steroid hormone production in follicles and granulosa cells. Prohibitin expression is upregulated by chemerin and knockdown of prohibitin attenuates the suppressive role of chemerin on steroidogenesis, an action regulated by Akt. Using an androgenized rodent model, we also present the dysregulation of chemerin and prohibitin and their association with dysregulated follicular steroidogenesis. Our data and preliminary clinical studies demonstrate the potential involvement of chemerin and prohibitin in the etiology of PCOS. These studies significantly improve the knowledge of ovarian functions and the pathophysiology of PCOS, and provide important clues for the development of novel diagnosis biomarkers and new treatment strategies for this complex syndrome.
APA, Harvard, Vancouver, ISO, and other styles
7

Meerasahib, Mohamed Fareez. "Development and applications of monoclonal antibodies to TGFβ superfamily members involved in ovarian follicular development." Thesis, Oxford Brookes University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432722.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Li, Julang. "Role and regulation of prostaglandin production in granulosa cell DNA synthesis during ovarian follicular development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq26131.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Christensen, Ana Carolina Martinelli. "Effect of progesterone priming on ovarian angiogenic factors during late follicular and early luteal development." Thesis, Aberystwyth University, 2009. http://hdl.handle.net/2160/e0c6526a-aa08-44f1-ae9f-38e209cca761.

Full text
Abstract:
Infertility is a major issue in both human and animal medicine with a great economic impact on reproduction. In order to better understand the common causes of infertility it is necessary to understand the basic physiology underlying the complex process of folliculogenesis and luteogenesis (Campbell et al., 2003). The lack of extensive understanding of the factors involved in regulating follicular and oocyte maturation has resulted in the slow process of developing in vitro systems for the study of folliculogenesis (Campbell et al., 2004). However, domestic ruminants represent a valuable in vivo model system for the study of the endocrine and local mechanisms regulating follicular development not only in ruminants but also in humans (Campbell et al., 2003) and have thus been extensively used in reproduction research. Improved understanding of the basic cellular mechanisms of ovarian physiology may improve biotechnology strategies in livestock reproduction and enhance fertility protocols for endangered species. Similarly, a better understanding of these reproductive processes could lead to innovative strategies to improve reproductive health in women.
APA, Harvard, Vancouver, ISO, and other styles
10

Schauer, Stephanie Nicole. "Role of luteinising hormone in ovarian follicle development and maturation in the mare." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/11731.

Full text
Abstract:
Luteinising hormone (LH) is a crucial regulator of ovarian follicle maturation, ovulation and luteinisation. Development of healthy follicles and fertile ovulation can only occur within a specific range of circulating LH concentrations, with differing upper and lower limits depending on the stage of the oestrous cycle. The objective of the three studies in this thesis was to investigate the effects of both physiological and non-physiological circulating LH levels on equine follicular maturity by examining ovulatory and steroidogenic capacity, gene expression profiles and miRNA expression in ovulatory-size follicles at various stages of the oestrous cycle and/or in response to supplementation with LH. The aim of the first study was to investigate the hypothesis that deficient circulating LH is a primary cause for the inability of equine follicles to ovulate during the physiological anovulatory season. A LH-rich equine pituitary fraction (eLH) given twice daily to early transitional mares did not restore steroidogenic capacity of the ovulatory-size follicle or advance the onset of the natural breeding season; however, it significantly stimulated follicular growth to a level similar to that occurring during the normal oestrous cycle. The results demonstrated that a deficiency in LH is critically involved in reduced follicle growth during the anovulatory season. The second study examined the effects of elevated circulating LH levels early during follicle development on follicle maturation and ovulatory ability in cycling mares, with the hypothesis that excessive LH would disrupt ovulation and produce haemorrhagic anovulatory follicles (HAFs). Treatment with eLH or a luteolytic dose of prostaglandin F2α (to stimulate an increase in endogenous levels of LH) did not have any effects on follicle growth or ovulation, but did impair follicular production of androstenedione and insulin-like growth factor 1 (IGF1), suggesting a deleterious effect of high LH on follicle and oocyte maturation. The third study examined the expression of different follicular factors associated with follicle maturation as well as microRNAs (miRNAs) in ovulatory-size follicles naturally developing under different LH milieus (oestrus, dioestrus and spring transitional period). Progesterone and IGF1 were significantly reduced in follicles developing in a low LH environment (dioestrus and transition). All four miRNAs measured, miR-378, miR-542, miR-202 and miR-21 were found at higher levels in subordinate follicles than in preovulatory follicles during oestrus. In addition miR- 202 and miR-21 were significantly increased in transitional follicles relative to oestrous follicles. The results of this study indicate that follicles developing during both the spring transitional and dioestrous periods are developmentally immature and suggested potential important roles of miRNAs in follicle maturation in the horse. In summary, although LH is a key factor promoting follicular growth, it is by itself not sufficient to restore steroidogenic activity in transitional follicles. Elevated LH levels during follicle development do not disrupt ovulation, but induce changes in follicular fluid factors related to follicle maturation and oocyte quality. Follicles developing under different LH milieus show altered miRNA expression, suggesting an important role of miRNAs in follicle maturation.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Ovarian Follicular Development"

1

Galvin, James A. Ovarian follicular development following oestrus syncronization programmes at different stages of the oestrous cycle in lactating dairy cows. Dublin: University College Dublin, 1995.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Deshpande, Rohini Rajendra. Immune system parameters associated with development of follicular cystic ovaries induced by neonatal estradiol injection. 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Ovarian Follicular Development"

1

Mori, Takahide. "Regulatory Principles of Follicular Development." In Ovarian Stimulation Protocols, 1–16. New Delhi: Springer India, 2016. http://dx.doi.org/10.1007/978-81-322-1121-1_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Farookhi, Riaz, and Orest W. Blaschuk. "Cadherins and Ovarian Follicular Development." In Signaling Mechanisms and Gene Expression in the Ovary, 254–60. New York, NY: Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4612-3200-1_25.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Bian, Na, Mark G. Eramian, and Roger A. Pierson. "Evaluation of Texture Features for Analysis of Ovarian Follicular Development." In Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006, 93–100. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11866763_12.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Ryan, Kenneth J., and Anastasia Makris. "Significance of Angiogenic and Growth Factors in Ovarian Follicular Development." In Advances in Experimental Medicine and Biology, 203–9. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5395-9_10.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Roy, Shyamal K., Cheng Wang, Anindit Mukherjee, and Prabuddha Chakraborty. "In Vitro Culture of Fetal Ovaries: A Model to Study Factors Regulating Early Follicular Development." In Methods in Molecular Biology, 151–71. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-61779-436-0_12.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

RICHARDS, JOANNE S., TORE JAHNSEN, LARS HEDIN, JAMI LIFKA, SHERI RATOOSH, JON M. DURICA, and NOGA B. GOLDRING. "Ovarian Follicular Development: From Physiology to Molecular Biology." In Proceedings of the 1986 Laurentian Hormone Conference, 231–76. Elsevier, 1987. http://dx.doi.org/10.1016/b978-0-12-571143-2.50012-5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Zhang, Zhenghong, Yan Zhang, Fengping Lin, and Zhengchao Wang. "Endocrine Characteristics and Regulatory Mechanism of Follicular Development and Ovulation Failure in Mammalian Ovary." In Polycystic Ovarian Syndrome. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.89625.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Duda, Malgorzata, Kamil Wartalski, Zbigniew Tabarowski, and Gabriela Gorczyca. "The Role of Androgens in Ovarian Follicular Development: From Fertility to Ovarian Cancer." In Theriogenology. InTech, 2017. http://dx.doi.org/10.5772/intechopen.68881.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Richards, JoAnne S. "From Follicular Development and Ovulation to Ovarian Cancers: An Unexpected Journey." In Vitamins and Hormones, 453–72. Elsevier, 2018. http://dx.doi.org/10.1016/bs.vh.2018.01.019.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Ojeda, Sergio R. "Female Reproductive Function." In Textbook of Endocrine Physiology. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199744121.003.0011.

Full text
Abstract:
The production of germ cells is essential for the continuation of a species. In the female this function is accomplished by the ovaries. In addition, the ovaries secrete steroids and nonsteroidal hormones that not only regulate the secretion of anterior pituitary hormones but also act on various target organs, including the ovaries themselves, the uterus, fallopian tubes, vagina, mammary gland, and bone. Morphologically, the ovary has three regions: an outer cortex that contains the oocytes and represents most of the mass of the ovary; the inner medulla, formed by stromal cells and cells with steroid-producing characteristics; and the hilum, which, in addition to serving as the point of entry of the nerves and blood vessels, represents the attachment region of the gland to the mesovarium. The cortex, which is enveloped by the germinal epithelium, contains the follicles, which are the functional units of the ovary. They are present in different states of development or degeneration (atresia), each enclosing an oocyte. In addition to the oocyte, ovarian follicles have two other cellular components: granulosa cells, which surround the oocyte, and thecal cells, which are separated from the granulosa cells by a basal membrane and are arranged in concentric layers around this membrane. The follicles are embedded in the stroma, which is composed of supportive connective cells similar to that of other tissues, interstitial secretory cells, and neurovascular elements. The medulla has a heterogeneous population of cells, some of which are morphologically similar to the Leydig cells in the testes. These cells predominate in the ovarian hilum; their neoplastic transformation results in excess androgen production. The ovary produces both steroids and peptidergic hormones. Whereas the steroids are synthesized in both interstitial and follicular cells, peptidergic hormones are primarily produced in follicular cells and, after ovulation, by cells of the corpus luteum. The initial precursor for steroid biosynthesis is cholesterol, which derives from animal fats of the diet or from local synthesis.
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Ovarian Follicular Development"

1

Wang, Zhaokai, Zhenghong Zhang, Lixiang Wu, Jiajie Chen, and Zhengchao Wang. "HIF-1alpha Sliencing is a Tool for Establishing Biological Information Network on Cell Engneering of Ovarian Follicular Development in Sprague-Dawley Rats Primed by PMSG." In 2015 Seventh International Conference on Measuring Technology and Mechatronics Automation (ICMTMA). IEEE, 2015. http://dx.doi.org/10.1109/icmtma.2015.132.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Redding, Gabe P., and John E. Bronlund. "Engineering as a Tool in Assisted Reproduction: An Investigation Using Mathematical Modelling of Oxygen Transport in the Ovarian Follicle." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-66519.

Full text
Abstract:
The key objective of any Assisted Reproductive Technology (ART) is to provide infertile couples with the maximal chance of producing healthy offspring and there is a large body of research within this field directed toward this objective. However, despite this volume of research attention, the success rates of many procedures such as In-Vitro fertilization (IVF) have improved little since their inception. Engineering principles have not been widely applied to ART and, as a result, it appears that there is great potential for engineering to make a contribution to this field. The objectives of this work were to demonstrate the usefulness of engineering principles in this field via the example of modelling oxygen transport in the preovulatory human ovarian follicle. The results show mathematical relationships between follicular fluid dissolved oxygen levels, follicular vascularity and the developmental potential of the oocyte can be described. These relationships are shown to be consistent with findings reported in the literature. Significant results include the emergence of cut off levels of both follicular vascularity and follicle size below which all eggs will be starved of oxygen. Based on current model parameters these cut off levels are predicted to range from 22–40% and 3.5–4.3 ml (19.0–20.3 mm follicle diameter) for follicle vascularity and volume respectively. These results serve to highlight the potential contribution of engineering in general to ART. The implications of these findings are also discussed as are future improvements for modelling mass transport in the ovarian follicle.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Ovarian Follicular Development' for particular source types:
Journal articles Dissertations / Theses
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography