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Journal articles on the topic 'Ovarian metastasis'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Falchook, G. S., G. R. Varadhachary, and R. A. Wolff. "Retrospective review of patients with adenocarcinoma of the pancreas and ovarian metastasis: Clinical characteristics, treatment strategies, and survival data." Journal of Clinical Oncology 24, no. 18_suppl (2006): 14068. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.14068.

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14068 Background: Ovarian metastasis from pancreatic adenocarcinoma is rare, and data on clinical features, treatment, and survival are limited. Methods: Charts of 19 patients with pancreatic adenocarcinoma and ovarian metastasis identified by the UTMDACC tumor registry from 1984–2005 were reviewed. Results: Clinical characteristics and survival data are in the Table. Data were limited in patients seen for single-visit second-opinion consultation or for whom only pathology was available. Other synchronous metastatic sites included peritoneum (11), liver (9), lung (5), fallopian tubes (4), uter

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Thornblade, Lucas W., Ernest Han, and Yuman Fong. "Colorectal cancer ovarian metastases." International Journal of Gynecologic Cancer 31, no. 8 (2021): 1137–44. http://dx.doi.org/10.1136/ijgc-2020-002328.

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ObjectiveOvarian metastases occur in 3%–5% of patients with colorectal cancer. The role of oophorectomy in that setting continues to be debated. We aimed to assess the survival of women treated with metastasectomy for ovarian metastasis.MethodsRetrospective cohort study of patients in the California Cancer Registry (2000–2012) with stage IV colorectal cancer and ovarian metastases. Pathology other than adenocarcinoma was excluded. Adjusted Cox-proportional hazard analysis was applied to assess the risk of death.ResultsA total of 756 patients with synchronous ovarian metastases and 516 patients

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Kulal, Santhosha, Manjunath G N, and Abhay K. Kattepur. "Uninvited Guest in the H ouse: A Rare Case of Metastatic Gallbladder Cancer." JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES 13, no. 4 (2023): 133–35. http://dx.doi.org/10.58739/jcbs/v13i4.23.8.

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Gallbladder cancer is a rare malignancy. About 1–2% of surgical specimens demonstrated a gallbladder cancer as an incidental finding. Metastasis to ovaries by biliary origin, known as Krukenberg tumour, though known, is infrequent. It can mimic clinically and morphologically, as a primary ovarian tumour challenging the diagnosis. Diagnosis of secondary ovarian tumours though its challenging often misdiagnosed as primary ovarian cancer, specifically mucinous adenocarcinomas. The distinction from the latter is essential, as it requires different treatment. Immunohistochemistry plays an important

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Yamanishi, Yukio, Masafumi Koshiyama, Megumi Ohnaka, et al. "Pathways of Metastases from Primary Organs to the Ovaries." Obstetrics and Gynecology International 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/612817.

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To investigate the metastatic pathways from the primary organs to the ovaries, we examined the microscopic findings from 18 original and 18 metastatic ovarian tumors carefully. In addition, we examined the immunohistochemical findings (Victoria blue stain for vascular invasion and D2-40 expression for lymphangio invasion) of metastatic ovarian tumors carefully. There were 4 (57%) ovarian lymphangio invasion cases in the 7 gastric cancers, but there were no cases in the 6 colorectal cancers (P< 0.05). There were 4 (67%) ovarian vascular invasion cases and one (17%) liver metastasis case in t

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Dandapani, Monica, Brandon-Luke L. Seagle, Amer Abdullah, Bryce Hatfield, Robert Samuelson, and Shohreh Shahabi. "Metastatic Uterine Leiomyosarcoma Involving Bilateral Ovarian Stroma without Capsular Involvement Implies a Local Route of Hematogenous Dissemination." Case Reports in Obstetrics and Gynecology 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/950373.

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Uterine sarcomas spread via lymphatic and hematogenous dissemination, direct extension, or transtubal transport. Distant metastasis often involves the lungs. Ovarian metastasis is uncommon. Here we present an unusual case of a large, high-grade uLMS with metastatic disease internal to both ovaries without capsular involvement or other abdominal diseases, and discovered in a patient with distant metastases to the lungs, suggesting likely hematogenous dissemination of uLMS to the ovaries in this case. Knowledge of usual uLMS metastases may influence surgical management in select cases.

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Gurbuz, A., G. Kir, A. Karateke, B. Haliloglu, and C. Kabaca. "Metastatic ovarian carcinoma one year after surgical removal of colon carcinoma during pregnancy: a case report." International Journal of Gynecologic Cancer 16, Suppl 1 (2006): 330–33. http://dx.doi.org/10.1136/ijgc-00009577-200602001-00057.

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Colorectal carcinoma during pregnancy is a very rare event. We presented a woman with metachronous metastatic ovarian tumor existing 1 year after surgical removal of perforated sigmoid colon carcinoma encountered during cesarean section of woman of 36-week gestation for fetal distress. Pregnant women with suspicious abdominal mass should be evaluated for a possible colorectal carcinoma even in the absence of any other gastrointestinal symptoms associated with it and undergo rectal examination and sigmoidoscopy. In addition, as synchronous and metachronous ovarian metastases are common in these

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Pipal, Vibha Rani, Pratibha Singh, Dharmendra Kumar Pipal, and Poonam Elhence. "Skin Metastases in Ovarian Malignancy: A Case Report with Literature Review." Journal of Mid-life Health 14, no. 1 (2023): 49–52. http://dx.doi.org/10.4103/jmh.jmh_137_22.

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ABSTRACT Ovarian cancer is the most lethal gynecologic malignancy, mostly diagnosed in the advanced stage with multiple sites of metastases. Routes of spread are direct through exfoliation, lymphatic channels, and less commonly hematogenous spread. Skin metastasis in ovarian malignancy is a rare occurence, its incidence range from 1.9% to 5.1% and the most common sites are the abdominal wall and chest wall. The incidence of metastasis to breast and/or axillary lymph nodes is very rare, ranging from 0.03% to 0.6%. We report the case of a 60-year-old female with stage IV B undifferentiated ovari

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TAY, S. K., and H. RAJESH. "Brain metastases from epithelial ovarian cancer." International Journal of Gynecologic Cancer 15, no. 5 (2005): 824–29. http://dx.doi.org/10.1136/ijgc-00009577-200509000-00018.

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Brain metastasis from epithelial ovarian cancer is uncommon. We studied the presentation, treatment, and prognosis of brain metastasis in a single institution. A retrospective review of clinical details kept in the computer database of gynecologic oncology services in a tertiary institution between 1993 and 2003 was done. A Medline search for English publications on brain metastasis from epithelial ovarian cancer was performed from 1966 to 2003. The study period included 605 patients, and 4 (0.66%) patients developed brain metastases. The patients were usually well, until they presented with h

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Turanjanin, Dragan, Nikola Stipic, Nevena Stanulovic, and Nikola Gardic. "Risk factors for peritoneal dissemination of ovarian cancer." Medical review 76, no. 11-12 (2023): 331–37. http://dx.doi.org/10.2298/mpns2312331t.

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Introduction. Ovarian epithelial tumors constitute 60% of all ovarian tumors and approximately 90% of primary ovarian tumors. Most patients are diagnosed at an advanced stage of the disease. Epithelial ovarian tumors typically spread via transcoelomic dissemination, with about 70% of patients presenting with peritoneal metastases. Additionally, cancers can metastasize to the pelvic lymph nodes. The objective of this study was to identify which clinical characteristics of malignant ovarian cancer might influence the occurrence of peritoneal metastases. Material and Methods. This retrospective s

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Wang, Wei, Chun-Chi Lin, Wen-Yi Liang, Shih-Ching Chang, and Jeng-Kai Jiang. "Adenocarcinoma of sigmoid colon with metastasis to an ovarian mature teratoma: A case report." World Journal of Clinical Cases 12, no. 4 (2024): 853–58. http://dx.doi.org/10.12998/wjcc.v12.i4.853.

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BACKGROUND Colorectal cancer ranks third in global cancer-related mortality, often due to metastases to liver and lungs. Ovarian metastases are less common, accounting for 3.6% to 7.4% of cases. In contrast, mature ovarian teratomas are frequently benign. Tumor-to-tumor metastasis is a rare phenomenon, with a limited number of documented cases. Three cases of mature ovarian teratomas metastasizing from different cancers have been reported. This report focuses on a case of tumor-to-tumor metastasis from sigmoid colon adenocarcinoma to a mature ovarian teratoma. CASE SUMMARY A 41-year-old Taiwan

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Fillmann, Lúcio Sarubbi, Henrique Sarubbi Fillmann, Laura Pinho Fillmann, Ana Paula Reginatto Tubiana, Raquel Ribeiro, and Mariana Coelho. "Ovarian Metastasis from Colorectal Adenocarcinoma." Journal of Coloproctology 41, no. 02 (2021): 176–81. http://dx.doi.org/10.1055/s-0041-1730426.

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Abstract Introduction Ovarian metastases of gastrointestinal origin, also called Krukenberg tumors, have a guarded prognosis. Physicians need to look for alternatives in diagnosis and treatment for this clinical condition in order to improve the outcome of the patients. Objectives To report the experience of the authors in the treatment of these patients, and to perform a review of the literature on the epidemiology, clinical presentation, diagnosis, treatment, and prognosis for ovarian metastases from colorectal cancer. Methods We collected clinical information regarding the patients treated

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Ray, Upasana, Deok-Beom Jung, Ling Jin, et al. "Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer." Cancer Research 82, no. 6 (2022): 1038–54. http://dx.doi.org/10.1158/0008-5472.can-21-0622.

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Abstract Dissemination of ovarian cancer cells can lead to inoperable metastatic lesions in the bowel and omentum that cause patient death. Here we show that LRRC15, a type-I 15-leucine–rich repeat-containing membrane protein, highly overexpressed in ovarian cancer bowel metastases compared with matched primary tumors and acts as a potent promoter of omental metastasis. Complementary models of ovarian cancer demonstrated that LRRC15 expression leads to inhibition of anoikis-induced cell death and promotes adhesion and invasion through matrices that mimic omentum. Mechanistically, LRRC15 intera

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13

Otsuka. "Cutaneous Metastases in Ovarian Cancer." Cancers 11, no. 9 (2019): 1292. http://dx.doi.org/10.3390/cancers11091292.

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Skin metastases in ovarian cancer are uncommon, but their incidence may be increasing due to improved survival rates. Skin metastases can be divided into umbilical metastases, which are known as Sister Joseph nodules (SJNs) and are associated with peritoneal metastasis, and non-SJN skin metastases, which usually develop within surgical scars and in the vicinity of superficial lymphadenopathy. As most skin metastases develop after specific conditions, recognition of preceding metastatic diseases and prior treatments is necessary for early diagnosis of skin lesions. The prognosis of skin metasta

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Piddubnyi, Artem, Iryna Tkachenko, Pavlo Shubin, and Oleksii Korenkov. "METASTATIC OVARIAN CANCER: BIBLIOGRAPHIC ANALYSIS." Eastern Ukrainian Medical Journal 11, no. 4 (2023): 352–59. http://dx.doi.org/10.21272/eumj.2023;11(4):352-359.

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Introduction. Ovarian cancer is an oncogynecological disease with high mortality. High mortality caused by this pathology is associated with diagnosis at the III–IV stage of the disease. This stage of the disease is characterized by metastasis and reflected in the 5-year survival rate, decreasing to 30.2 %. At the same time, when diagnosed at the I-II stage, this indicator is 92.6%. The aim of the work is bibliometric analysis and generalization of data from scientific sources on the study of ovarian cancer metastasis. Materials and methods. Information was searched on electronic resources of

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Roland, Adjoby Cassou, Kouamé Arthur Didier, Koffi Achille, et al. "Metastatic ovarian tumor of a lung cancer at the hospital center of Chauny (France): a case report." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 10 (2017): 4682. http://dx.doi.org/10.18203/2320-1770.ijrcog20174464.

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The ovary is an organ that can be the site of metastases for many cancers. In general, malignant ovarian tumors are primary; however, cases of extra gynecological metastatic tumors (breast, colon, stomach, and pancreas) have been reported. In most cases, the primary cancers of these ovarian tumors are gastrointestinal or gynecological, the lung being very rarely involved. We report a rare case of ovarian metastases of bronchial cancer discovered during an extensional assessment. The histological examination coupled with immunohistochemistry concludes that ovarian metastasis of small cell lung

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Karpathiou, Georgia, Florian Camy, Céline Chauleur, Maroa Dridi, Pierre Dal Col, and Michel Peoc’h. "Brain Metastases from Gynecologic Malignancies." Medicina 58, no. 4 (2022): 548. http://dx.doi.org/10.3390/medicina58040548.

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Background and Objectives: To present a series of brain metastases from gynecologic primaries and provide a summary of the relevant literature. Materials and Methods: We retrospectively review 18 patients with histologically confirmed brain metastases from gynecologic primaries and summarize the largest series of relative reports. Results: Six brain metastases were of endometrial primary and 12 of ovarian primary. In 3 cases (16.7%), diagnosis of brain metastases was made at presentation of the gynecologic primary; in the others, median time to development of brain metastasis was 34 (range, 6–

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Omranipour, Ramesh, and Abolghasem Abasahl. "Ovarian Metastases in Colorectal Cancer." International Journal of Gynecologic Cancer 19, no. 9 (2009): 1524–28. http://dx.doi.org/10.1111/igc.0b013e3181a84011.

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Purpose:The aims of this study were to determine the incidence, clinicopathologic features, and prognostic factors of ovarian involvement in primary colorectal cancer (CRC) and also to clear the role of prophylactic oophorectomy.Methods:Data from women with primary CRC treated between 1990 and 2004 were retrieved, and clinical and pathologic features of those who had undergone oophorectomy during CRC surgery were reviewed.Results:One hundred eighty cases (mean age, 48 years) were included. In 120 cases, ovaries were preserved, and 60 cases underwent bilateral oophorectomy in addition to primar

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18

Lin, Xiaolin, Ting Han, Meng Zhuo, et al. "Clinicopathological characteristics and prognostic factors of 130 patients with Krukenberg tumors of gastric origin." Journal of Clinical Oncology 40, no. 16_suppl (2022): e16023-e16023. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e16023.

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e16023 Background: Krukenberg tumors of gastric origin have a poor prognosis. Their clinicopathologic characteristics are rarely reported and they lack optimal clinical management. There is an urgent need to explore new strategies to improve patient survival and quality of life. Methods: The clinicopathological characteristics, treatments and survival data were collected and analyzed from 130 patients with Krukenberg tumors of gastric cancer. Results: The median age of the patients was 41 years. A total of 63.1% of patients had synchronous ovarian metastasis, 70.8% had bilateral ovarian metast

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Lin, Xiaolin, Ting Han, Meng Zhuo, et al. "Clinicopathological characteristics and prognostic factors of 130 patients with Krukenberg tumors of gastric origin." Journal of Clinical Oncology 40, no. 16_suppl (2022): e16023-e16023. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e16023.

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e16023 Background: Krukenberg tumors of gastric origin have a poor prognosis. Their clinicopathologic characteristics are rarely reported and they lack optimal clinical management. There is an urgent need to explore new strategies to improve patient survival and quality of life. Methods: The clinicopathological characteristics, treatments and survival data were collected and analyzed from 130 patients with Krukenberg tumors of gastric cancer. Results: The median age of the patients was 41 years. A total of 63.1% of patients had synchronous ovarian metastasis, 70.8% had bilateral ovarian metast

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Nikolaou, Marinos, Srdjan Stamenkovic, Christos Stergiou, Christos Skarleas, and Michael Torrens. "Management of brain metastasis in a patient with advanced epithelial ovarian carcinoma by gamma-knife radiosurgery." Srpski arhiv za celokupno lekarstvo 143, no. 3-4 (2015): 205–9. http://dx.doi.org/10.2298/sarh1504205n.

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Introduction. Brain metastases from epithelial ovarian cancer (EOC) are rare events. We present a rare case of single ovarian cancer metastasis to the brain treated with gamma-knife radiosurgery (GKRS). Case Outline. A 65-year-old woman with advanced EOC presented with severe neurologic symptoms. A single brain metastasis of 3.2 cm with surrounding edema in the left parietal lobe was detected by brain magnetic resonance imaging (MRI) scan during the work-up. The decision to perform GKRS was due to a surgical inaccessibility of intracranial lesion. Twelve weeks after the procedure, the MRI scan

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Burdenny, Alexey M., Svetlana S. Lukina, Elena A. Filippova, et al. "The group of hypermethylated long noncoding RNA genes is associated with different types of metastasis in ovarian cancer." Almanac of Clinical Medicine 52, no. 3 (2024): 149–61. http://dx.doi.org/10.18786/2072-0505-2024-52-021.

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Background: Ovarian tumors are characterized by asymptomatic progression until their late stages, when at the time of diagnosis the patient already has extensive metastatic disease. In addition to lymphogenous and hematogenous metastasis in ovarian cancer, there are peritoneal dissemination and metastasis to the greater omentum with ascites; moreover, peritoneal carcinomatosis is the predominant route of metastasizing of ovarian cancer. Epigenetic factors, such as gene methylation, regulatory microRNAs and long non-coding RNAs (lncRNAs), contribute to progression of this cancer. Our previous b

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Psomiadou, Victoria, Alexandros Fotiou, and Christos Iavazzo. "Mediastinal Metastasis Isolated in Ovarian Cancer: A Systematic Review." Life 14, no. 9 (2024): 1098. http://dx.doi.org/10.3390/life14091098.

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Background: Isolated mediastinal metastases from ovarian carcinoma are considered exceptional. Since such metastases are considered advanced stage disease, systemic therapy is the indicated therapeutic approach; however, some articles report that surgical excision is also feasible. Methods: We reviewed the English-language literature to detect cases of isolated mediastinal ovarian cancer metastases and present the management applied as well as their outcomes. Results: From 1998 to 2022, 15 such cases have been reported, with 4 of those cases being primary ovarian cancer presentation and 11 bei

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Barbolina, Maria. "Molecular Mechanisms Regulating Organ-Specific Metastases in Epithelial Ovarian Carcinoma." Cancers 10, no. 11 (2018): 444. http://dx.doi.org/10.3390/cancers10110444.

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Epithelial ovarian carcinoma is the most predominant type of ovarian carcinoma, the deadliest gynecologic malignancy. It is typically diagnosed late when the cancer has already metastasized. Transcoelomic metastasis is the most predominant mechanism of dissemination from epithelial ovarian carcinoma, although both hematogenously and lymphogenously spread metastases also occur. In this review, we describe molecular mechanisms known to regulate organ-specific metastasis from epithelial ovarian carcinoma. We begin by discussing the sites colonized by metastatic ovarian carcinoma and rank them in

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Naldi, Giuseppe, Serenella Bergomi, Paolo Visca, and Fabiana Letizia Cecere. "Ovarian metastasis from malignant pleural mesothelioma." Tumori Journal 106, no. 6 (2020): NP49—NP51. http://dx.doi.org/10.1177/0300891620941610.

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Background: Malignant pleural mesothelioma (MPM) is a rare and aggressive disease of the pleura with a dismal prognosis. Distant metastases most commonly occur in the liver, spleen, and thyroid gland. To our knowledge, ovarian metastases have never been described. Case description: We describe a case of a woman with recurrent malignant pleural mesothelioma presenting a single ovarian metastasis, surgically resected. Conclusions: This case report highlights the importance of using a complete staging protocol in patients with MPM to improve patient management. A whole-body computed tomography (C

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Sassu, Carolina Maria, Claudia Marchetti, Giorgia Russo, et al. "Epithelial ovarian cancer and brain metastases: might theBRCAstatus, PARP inhibitor administration, and surgical treatment impact the survival?" International Journal of Gynecologic Cancer 34, no. 1 (2024): 88–98. http://dx.doi.org/10.1136/ijgc-2023-004980.

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ObjectiveTo evaluate disease characteristics and survival according toBRCAstatus, administration of poly-(ADP-ribose) polymerase inhibitors (PARPi), and surgery in patients with ovarian cancer and brain metastases.MethodsThis is a monocentric retrospective cohort of patients with ovarian cancer and brain metastases treated between 2000 and 2021. Data were collected by a retrospective review of medical records and analyzed according to: (1)BRCAmutation; (2) PARPi before and after brain metastases; (3) surgery for brain metastases.ResultsEighty-five patients with ovarian cancer and brain metasta

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Morinaga, Nobuhiro, Naritaka Tanaka, Yoshinori Shitara, et al. "Ten-Year Survival of a Patient Treated with Stereotactic Gamma Knife Radiosurgery for Brain Metastases from Colon Cancer with Ovarian and Lymph Node Metastases: A Case Report." Case Reports in Gastroenterology 10, no. 1 (2016): 204–11. http://dx.doi.org/10.1159/000445976.

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Brain metastasis from colorectal cancer is infrequent and carries a poor prognosis. Herein, we present a patient alive 10 years after the identification of a first brain metastasis from sigmoid colon cancer. A 39-year-old woman underwent sigmoidectomy for sigmoid colon cancer during an emergency operation for pelvic peritonitis. The pathological finding was moderately differentiated adenocarcinoma. Eleven months after the sigmoidectomy, a metastatic lesion was identified in the left ovary. Despite local radiotherapy followed by chemotherapy, the left ovarian lesion grew, so resection of the ut

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Khotimah, Fitria Khusnul, Anna Febriani, and Pungky Mulawardhana. "Ovarian cancer with pleural and lung metastasis in Dr. Soetomo Hospital, Surabaya, Indonesia, in 2014-2015." Majalah Obstetri & Ginekologi 26, no. 1 (2018): 7. http://dx.doi.org/10.20473/mog.v1i12018.7-19.

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Objectives: To know the characteristics of ovarian cancer patients with pleural and lung metastasis, and survival rates of ovarian cancer patients with pleural and lung metastasis in Dr. Soetomo Hospital Surabaya in 2014-2015.Materials & Methods: This was a descriptive observational study using secondary data from medical records in dr. Soetomo Hospital, Surabaya, Indonesia, in 2014 and 2015Results: Number of new patients of ovarian cancer in dr. Soe-tomo, Hospital, Surabaya in 2014 was 170 patients (14%) and 122 patients (12%) in 2015. Ovarian cancer patients most often came at the stage

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Khotimah, Fitria Khusnul, Anna Febriani, and Pungky Mulawardhana. "Ovarian cancer with pleural and lung metastasis in Dr. Soetomo Hospital, Surabaya, Indonesia, in 2014-2015." Majalah Obstetri & Ginekologi 26, no. 1 (2018): 7. http://dx.doi.org/10.20473/mog.v26i12018.7-19.

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Objectives: To know the characteristics of ovarian cancer patients with pleural and lung metastasis, and survival rates of ovarian cancer patients with pleural and lung metastasis in Dr. Soetomo Hospital Surabaya in 2014-2015.Materials & Methods: This was a descriptive observational study using secondary data from medical records in dr. Soetomo Hospital, Surabaya, Indonesia, in 2014 and 2015Results: Number of new patients of ovarian cancer in dr. Soe-tomo, Hospital, Surabaya in 2014 was 170 patients (14%) and 122 patients (12%) in 2015. Ovarian cancer patients most often came at the stage

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Lee, S., J. Lee, H. Ahn, et al. "The role of oophorectomy for colon cancer with ovarian metastasis." Journal of Clinical Oncology 27, no. 15_suppl (2009): e15113-e15113. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15113.

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e15113 Background: A recent study demonstrated that colorectal cancer with ovarian metastases were less responsive to chemotherapy compared to extraovarian metastases. Hence, the ovary may actually represent a “sanctuary” for metastatic cells from CRC. The aim of the study was to investigate the impact of oophorectomy on survival of colorectal cancer patients with ovarian metastasis. Methods: Between 1996 and 2008, 83 colorectal cancer patients underwent oophorectomy. For the historical control, 47 colorectal cancer patients without oophorectomy were included in the analysis. Survival and its

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Zakhartseva, L. M., O. P. Manzhura, I. Yu Vashchenko, et al. "Differential diagnosis of primary and metastatic ovarian carcinomas." Pathologia 20, no. 3 (2023): 281–88. http://dx.doi.org/10.14739/2310-1237.2023.3.291530.

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Ovarian tumors constitute 3.4 % of the structure of oncological diseases in women worldwide. However, the ovaries are also a common target for metastasis of carcinoma from other organs. Conducting differential diagnosis between primary carcinoma and metastasis is often challenging. The aim of this study is to highlight the issues of morphological and immunohistochemical differential diagnosis of primary ovarian carcinomas and metastases from carcinomas of various organs to the ovaries. Materials and methods. Data analysis of clinical and pathohistological studies of 381 patients. Paraffin sect

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Pengfei, Yu, Ling Huang, and Yian Du. "Treatment strategy and prognostic factors for Krukenberg tumors of gastric origin: Report of a 10-year single-center experience from China." Journal of Clinical Oncology 36, no. 4_suppl (2018): 52. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.52.

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52 Background: Gastric cancer patient with ovarian metastasis, i.e. Krukenberg tumor, is common in clinical practice, but it is still uncertain whether surgical resection of ovarian metastasis could improve the outcome. This study aimed to explore the survival benefit of metastasectomy plus chemotherapy over chemotherapy alone in the treatment of Krukenberg tumors arising from gastric cancer and to identify prognostic factors. Methods: All patients who were diagnosed with gastric cancer and ovarian metastases between January 2005 and December 2014 were included in the current study. Patients w

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Ak, Naziye, Yagmur Minareci, and Pinar Saip. "Skeletal system as a rare metastatic site in patients with ovarian carcinoma." International Journal of Gynecologic Cancer 31, no. 8 (2021): 1125–31. http://dx.doi.org/10.1136/ijgc-2021-002486.

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ObjectiveTo evaluate the frequency and predictors of bone metastasis in patients with ovarian cancer and to determine prognostic factors associated with this finding.MethodsPatients diagnosed with ovarian cancer between January 2009 and December 2019 were evaluated. Patients with radiologically or pathologically confirmed bone metastasis were included in the study. Survival was analyzed using Kaplan-Meier curves and compared using the log-rank test. Multivariate analysis of prognostic factors related to survival was performed using the Cox proportional hazards model.ResultsNineteen (2.6%) of 7

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Zhang, S., Q. D. Lin, and W. Di. "Suppression of human ovarian carcinoma metastasis by the metastasis‐suppressor gene,BRMS1." International Journal of Gynecologic Cancer 16, no. 2 (2006): 522–31. http://dx.doi.org/10.1136/ijgc-00009577-200603000-00010.

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Metastasis-suppressor genes, by definition, suppress metastasis without affecting tumorigenicity and, hence, present attractive targets as prognostic or therapeutic markers.BRMS1(breast cancer metastasis suppressor) has recently been identified as a metastasis-suppressor gene for human breast cancer and melanoma. Expression ofBRMS1messenger RNA (mRNA) in multitissue including normal prostate, ovarian, testis, and colon has been detected by northern blot analysis. We hypothesize that the role ofBRMS1in tumor progression may not be limited to breast cancer and melanoma. We previously found thatB

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Shaffer, Annabelle, David Krist, Emily Smith, et al. "DISP-03. FEMALE-SPECIFIC CANCER METASTASES TO THE BRAIN: OUTCOMES IN A MEDICALLY UNDERSERVED AREA." Neuro-Oncology 24, Supplement_7 (2022): vii127. http://dx.doi.org/10.1093/neuonc/noac209.485.

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Abstract INTRODUCTION Cancer care in medically underserved areas (MUA) is challenging and not widely reported. This report seeks to characterize the outcomes of female patients with brain metastases from breast, ovarian, cervical, and endometrial cancer who underwent surgical resection in an MUA. METHODS Our institution’s electronic medical record was queried for patients who underwent a craniotomy from 2013-2022. All female patients with brain metastasis from breast, ovarian, cervical, or endometrial cancer were included. The following variables were collected: alive or deceased, survival tim

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Taseva, Dr. Anna, V. Ivanova, Elena Arabadzhieva, and Atanas Yonkov. "Clinical case of metachronous ovarian metastases from colon cancer - observation of a clinical case and review of the literature." Surgery 87, no. 3 (2023): 128–32. https://doi.org/10.5281/zenodo.14860847.

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The incidence of ovarian metastases from colorectal cancer is relatively low in the range of 3-14%, and metachronous metastases are even lower 1.3-2.4%. In most cases, they occur in old age, during menopause and 12 months after diagnosis with CRC, creating some diagnostic challanges.We present a clinical case of a 78-year-old woman who underwent emergency surgery for colon adenocarcinoma. One year later, bilateral ovarian lesions and peritoneal carcinosis were found. The performed colonoscopy did not detect recurrent colon tumor. The patient underwent a hysterectomy with bilateral adnexectomy.

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Koufopoulos, Nektarios, Abraham Pouliakis, Ioannis Boutas, et al. "Axillary Lymph Node Metastasis from Ovarian Carcinoma: A Systematic Review of the Literature." Journal of Personalized Medicine 13, no. 11 (2023): 1532. http://dx.doi.org/10.3390/jpm13111532.

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Background: Axillary lymph node metastasis is a rare stage IV ovarian carcinoma manifestation. This manuscript aims to systematically review the literature regarding axillary lymph node metastasis from ovarian carcinoma. Methods: We searched three medical internet databases (PubMed, Scopus, and Web of Science) for relevant articles published until 22 July 2023. Cases describing supraclavicular or intramammary lymph node metastases and concurrent metastasis to the breast were excluded. Results: After applying eligibility/inclusion and exclusion criteria, twenty-one manuscripts describing twenty

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Tîrnovanu, Mihaela Camelia, Irina Daniela Florea, Adina Tănase, et al. "Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature." Medicina 57, no. 6 (2021): 534. http://dx.doi.org/10.3390/medicina57060534.

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Ovarian malignant germ cell tumors (OMGCT) represent less than 10% of all ovarian tumors. Dysgerminoma is the most common malignant primitive germ cell tumor in young women, known for its curability and low propensity to invade and metastasize when diagnosed early. Herein, we report an unusual type of ovarian dysgerminoma (OD) metastasis with a brief review of the literature, lacking similar reported cases. To our knowledge, although there are several case reports of dysgerminoma metastases with variable anatomic location and presentation, vaginal metastasis has not been previously described.

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Beyshembaev, A. M., M. Sh Temirova, K. I. Zhordania, and A. Yu Kashurnikov. "Features of metastasis and recurrence in patients with stromal cell ovarian tumors." Pelvic Surgery and Oncology 10, no. 3-4 (2020): 54–59. http://dx.doi.org/10.17650/2686-9594-2020-10-3-4-54-59.

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Objective: a retrospective analysis of association of the tumor stage of stromal cell ovarian tumors with the frequency of recurrence and development of metastases in lymph nodes.Materials and methods. 473 patients with stromal cell ovarian tumors with various histological types were examined, and long-term treatment results were evaluated.Results. The highest recurrence rate (more than 80 %) was observed in stages II, III and IV. The frequency of development of metastases in the lymph nodes was highest in patients with stromal cell ovarian tumors of III–IV stages (50 %); however, in more than

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Huang, Pei-Ching, Ren-Chin Wu, Yu-Hsiang Juan, et al. "Diagnostic Accuracy of Whole-Body Computed Tomography for Incidental Ovarian Tumors in Patients with Prior Breast Cancer." Diagnostics 12, no. 2 (2022): 347. http://dx.doi.org/10.3390/diagnostics12020347.

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Whole-body computed tomography (WBCT) serves as the first-line imaging modality for breast cancer follow-up. To investigate the imaging characteristics and diagnostic accuracy of WBCT for incidental ovarian tumors in patients with prior breast cancer, we retrospectively reviewed a consecutive cohort of 13,845 patients with breast cancer, of whom 149 had pathologically-proven ovarian lesions. We excluded patients with ovarian diagnosis before breast cancer, CT scan not including ovary, CT-pathology interval >30 days, and severe CT artifact. Among our 60 breast cancer patients (median age, 46

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Joseph, Julie, Bindu C. S., Saikiran Reddy, and Sathi P. P. "Appendiceal neuroendocrine tumour presenting as bilateral ovarian and breast metastasis." International Surgery Journal 4, no. 5 (2017): 1789. http://dx.doi.org/10.18203/2349-2902.isj20171484.

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Neuroendocrine tumours (NETs) of the appendix (formerly known 'carcinoids') are rare and are usually detected incidentally after appendectomy. The reported frequency of metastases from appendiceal carcinoids is gradually increasing, may be due to the increased longevity of the patients with benign/malignant diseases. Here we report a case of NET of appendix in an 80 year old female who presented with bilateral ovarian mass, and later developed metastasis in the breast. Though uncommon, NETs producing bilateral ovarian metastasis is well described in literature, the commonest primary being ileu

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Khan, Shaheena, Jennifer L. Taylor, and Carrie W. Rinker-Schaeffer. "Disrupting Ovarian Cancer Metastatic Colonization: Insights from Metastasis Suppressor Studies." Journal of Oncology 2010 (2010): 1–7. http://dx.doi.org/10.1155/2010/286925.

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Ovarian cancer affects approximately 25,000 women in the United States each year and remains one of the most lethal female malignancies. A standard approach to therapy is surgical cytoreduction, after which the remaining microscopic residual disease is treated with chemotherapy. The vast majority of patients have disease recurrence, underscoring the crucial need for approaches to control the regrowth, or colonization, of tissues after local treatment. Improved therapies require mechanistic information about the process of metastatic colonization, the final step in metastasis, in which cancer c

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Mallick, Arati, Saubhagya K. Jena, and Debasis Kuanar. "Bilateral ovarian serous cystadenocarcinoma metastasizing to cervix: a rare case report." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 11 (2018): 4789. http://dx.doi.org/10.18203/2320-1770.ijrcog20184550.

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Ovarian carcinoma is the second most common gynaecologic cancer and the leading cause of death from gynaecologic malignancy. Two-third of all malignant epithelial ovarian tumors are constituted by serous ovarian cystadenocarcinomas. It is generally observed that ovarian cancer tends to remain intraabdominal even in advanced cases and that dissemination is usually by invasion of adjacent viscera, diffuse intraperitoneal implantation, and metastatic involvement of aortic and pelvic lymph nodes. Metastasizes to the uterine cervix, vagina, or vulva in ovarian cancer is rare. The reverse i.e. ovari

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Monica, S. Mary, Geetha Mohan, and K. N. Ashwini. "A Case Report of Krukenberg’s Tumour." Indian Journal of Continuing Nursing Education 25, no. 2 (2024): 92–97. https://doi.org/10.4103/ijcn.ijcn_78_24.

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Krukenberg’s tumour is usually but not always a bilateral involvement of ovaries from metastatic deposit from adenocarcinoma of the stomach and rarely from other gastrointestinal (GI) and non-GI organs. The route of metastasis of this rare condition is still not proven. It is still uncertain whether surgical resection of ovarian metastases and or primary tumour could improve the outcome. This article discusses the care of a lady with Krukenberg’s tumour.

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Grabowski, Jacek P., Joanna Glajzer, Rolf Richter, et al. "Lymphovascular space invasion and Ki67 as predictors of lymph node metastasis in primary low grade serous ovarian cancer." International Journal of Gynecologic Cancer 31, no. 1 (2020): 98–103. http://dx.doi.org/10.1136/ijgc-2020-001950.

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ObjectiveLow grade serous ovarian cancers characterize a unique clinical pattern and likely less frequent incidence of lymphatic metastasis. The expression level of Ki67 is associated with differences in prognosis and therapy outcome. However, its expression in combination with lymphovascular space invasion has not been evaluated in the prediction of lymphatic metastasis.MethodsPatients with low grade serous ovarian cancer were identified in an institutional database. Patients with primary low grade serous ovarian cancer diagnosed and/or treated at our center between September 2000 and Decembe

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Olesinski, Tomasz. "Surgical treatment of gastric carcinoma with ovarian metastases." Current Issues in Pharmacy and Medical Sciences 30, no. 4 (2017): 195–97. http://dx.doi.org/10.1515/cipms-2017-0037.

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Abstract Ovarian metastases from extragenital neoplasms are rare. The prevalent sites of the primary tumors were the breast, colorectum and the stomach. The Krukenberg tumor (KT) is defined as a gastrointestinal cancer which metastasized to the ovaries. Metastasis to the ovary may appear at the time of diagnosis of the primary tumor (synchronous) or during observation (metachronous). Common clinical presentations are abdominal distention, pain, palpable mass, bloating, ascites or pain during sexual intercourse. Diagnosis can be made by ultrasound examinations, CT or EMR scans, laparotomy and/o

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Maeda, Michihide, Tsuyoshi Hisa, Hiroki Kurahashi, et al. "Surgical Management for Transposed Ovarian Recurrence of Cervical Cancer: A Systematic Review with Our Experience." Current Oncology 29, no. 10 (2022): 7158–70. http://dx.doi.org/10.3390/curroncol29100563.

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In early-stage cervical cancer, ovarian metastasis is relatively rare, and ovarian transposition is often performed during surgery. Although rare, the diagnosis and surgical approach for recurrence at transposed ovaries are challenging. This study focused on the diagnosis and surgical management of transposed ovarian recurrence in cervical cancer patients. A 45-year-old premenopausal woman underwent radical hysterectomy, bilateral salpingectomy, and pelvic lymphadenectomy following postoperative concurrent chemoradiotherapy for stage IB1 cervical cancer. During the initial surgery, the ovary w

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Jiang, Wei, Xueyan Ouyang, Chunjuan Jiang, et al. "A NOTCH1 Mutation Found in a Newly Established Ovarian Cancer Cell Line (FDOVL) Promotes Lymph Node Metastasis in Ovarian Cancer." International Journal of Molecular Sciences 24, no. 6 (2023): 5091. http://dx.doi.org/10.3390/ijms24065091.

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Peritoneal implantation and lymph node metastasis have different driving mechanisms in ovarian cancer. Elucidating the underlying mechanism of lymph node metastasis is important for treatment outcomes. A new cell line, FDOVL, was established from a metastatic lymph node of a patient with primary platinum-resistant ovarian cancer and was then characterized. The effect of NOTCH1-p.C702fs mutation and NOTCH1 inhibitor on migration was evaluated in vitro and in vivo. Ten paired primary sites and metastatic lymph nodes were analyzed by RNA sequencing. The FDOVL cell line with serious karyotype abno

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Bregenzer, Horst, Mehta, Novak, Repetto, and Mehta. "The Role of Cancer Stem Cells and Mechanical Forces in Ovarian Cancer Metastasis." Cancers 11, no. 7 (2019): 1008. http://dx.doi.org/10.3390/cancers11071008.

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Ovarian cancer is an extremely lethal gynecologic disease; with the high-grade serous subtype predominantly associated with poor survival rates. Lack of early diagnostic biomarkers and prevalence of post-treatment recurrence, present substantial challenges in treating ovarian cancers. These cancers are also characterized by a high degree of heterogeneity and protracted metastasis, further complicating treatment. Within the ovarian tumor microenvironment, cancer stem-like cells and mechanical stimuli are two underappreciated key elements that play a crucial role in facilitating these outcomes.

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Yang, Chang, Tianbo Liu, Bairong Xia, Lina Gu, and Ge Lou. "Correlation of Collagen Triple Helix Repeat Containing 1 Overexpression With Lymph Node and Peritoneal Metastasis in Epithelial Ovarian Cancer." International Journal of Gynecologic Cancer 27, no. 1 (2016): 22–27. http://dx.doi.org/10.1097/igc.0000000000000850.

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ObjectiveThis study aimed to reveal whether collagen triple helix repeat containing 1 (CTHRC1) was a predictor of peritoneal and lymph node metastases in epithelial ovarian cancer, which had not been researched by others previously.Materials and MethodsWestern blot analysis showed that dramatic overexpression of CTHRC1 could be seen in most metastatic tissues. Univariate and multivariate logistic regression analyses demonstrated that overexpression of CTHRC1 was linked with peritoneal dissemination and lymph node metastasis in epithelial ovarian cancer.ResultsThe negative and sensitivity-predi

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Kozachenko, V., J. Paianidi, M. Chekalova, and K. Jordania. "000326 SECONDARY OVARIAN METASTASIS." International Journal of Gynecologic Cancer 15, Suppl 2 (2005): 141.2–141. http://dx.doi.org/10.1136/ijgc-00009577-200509001-00322.

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