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Journal articles on the topic 'Ovaries Nanoparticles'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Journal, Baghdad Science. "Effect of the Silver Nanoparticles on the Histology of Albino Mice Ovaries." Baghdad Science Journal 14, no. 4 (2017): 662–68. http://dx.doi.org/10.21123/bsj.14.4.662-668.

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The aim of study is to identify the histological changes in ovaries of the albino mice exposed to silver nanoparticles. Sixty adult females were collected and exposures by 4000 p.p.m. and 50-150 nm in size, Females were divided into 3treated groups. The concentration dosage was (1, 1.5 and 2) p.p.m. of silver nanoparticles for 7, 14 and 21 days as exposure periods as well as control group which treated by normal saline. Treated groups appeared different histopathological changes, it is depending on the concentration of silver nanoparticles and the period of exposure. These changes were include

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2

Scsukova, Sona, Alzbeta Bujnakova Mlynarcikova, and Eva Rollerova. "The use of ex vivo ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-block-polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats." Endocrine Regulations 54, no. 1 (2020): 53–63. http://dx.doi.org/10.2478/enr-2020-0007.

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AbstractObjectives. Rapid development and widespread application of different types of nanoparticles (NPs) may result in increased exposure of humans and animals to NPs. Recently, reproductive toxicity due to NP exposure has become a major component of risk assessment. Current data have suggested that NPs may pose adverse effects on male and female reproductive health by altering normal testis and ovarian structure, and sex hormone levels. To detect possible alterations in steroidogenesis in adult and infantile rats following neonatal exposure to polymeric poly(ethylene glycol)-block-polylacti

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3

Taylor, Ulrike, Daniela Tiedemann, Christoph Rehbock, Wilfried A. Kues, Stephan Barcikowski, and Detlef Rath. "Influence of gold, silver and gold–silver alloy nanoparticles on germ cell function and embryo development." Beilstein Journal of Nanotechnology 6 (March 5, 2015): 651–64. http://dx.doi.org/10.3762/bjnano.6.66.

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The use of engineered nanoparticles has risen exponentially over the last decade. Applications are manifold and include utilisation in industrial goods as well as medical and consumer products. Gold and silver nanoparticles play an important role in the current increase of nanoparticle usage. However, our understanding concerning possible side effects of this increased exposure to particles, which are frequently in the same size regime as medium sized biomolecules and accessorily possess highly active surfaces, is still incomplete. That particularly applies to reproductive aspects, were defect

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4

Zhang, Dong Yin, Jian Peng Xue, Jun Mei Tian, et al. "Matriptase Sensitive Gold Nanoparticle Probe for early Cancer Detection." Advanced Materials Research 529 (June 2012): 301–5. http://dx.doi.org/10.4028/www.scientific.net/amr.529.301.

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Matriptase is a type II transmembrane serine protease highly expressed on the surface of tumor cells and participated in a range of human cancers including those of the breast, cervix, ovaries, prostate, colon and gastrointestinal tract. In this study, we developed a new matriptase detection probe with gold nanoparticles (AuNPs). A fluorescence dye was attached to AuNP surface through the bridge of peptide substrate (GRQSRAC). The fluorescence was quenched due to the fluorescence resonance energy transfer (FRET) between AuNP and the fluorescence dye. The fluorescence recovery properties were c

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Liu, Pai, Yeming Zhao, Sheng Wang, Hao Xing, and Wen-Fei Dong. "Effect of combined exposure to silica nanoparticles and cadmium chloride on female zebrafish ovaries." Environmental Toxicology and Pharmacology 87 (October 2021): 103720. http://dx.doi.org/10.1016/j.etap.2021.103720.

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Noori, Ali, Azita Amiri Baghbadorani, and Melika Golozar. "The effect of titanium dioxide nanoparticles injection in neonatal period on ovaries in mature rats." GSC Biological and Pharmaceutical Sciences 6, no. 1 (2019): 050–55. http://dx.doi.org/10.30574/gscbps.2019.6.1.0160.

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7

Behroozi-Lak, Tahereh, Malahat Ebrahimpour, Leila Zarei, Masoumeh Pourjabali, Negin Farhad, and Hamideh Mohaddesi. "Systemic administration of curcumin nanoparticles protects ischemia-reperfusion injury in ovaries: An animal model study." Revista da Associação Médica Brasileira 64, no. 1 (2018): 22–31. http://dx.doi.org/10.1590/1806-9282.64.01.22.

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8

Honardoust, Pouria, Alireza Najafpour, and Rahim Mohammadi. "Influence of Systemic Administration of Coq10 Nanoparticles on Ischemia-Reperfusion Injury on Ovaries in Rat." Evidence-Based Complementary and Alternative Medicine 2021 (July 23, 2021): 1–9. http://dx.doi.org/10.1155/2021/2303417.

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Using a rat ovary model, effects of COQ10 nanoparticles (NCOQ10) were studied on ischemia-reperfusion injury. In the present experimental study, following randomization of thirty healthy female Wistar rats ∼250 g, the animals were subjected to five experimental groups (n = 6): group SHAM : only laparotomy was performed, group IS: only a 3-hour ischemia was performed, group IS/REP: the procedure included a 3-hour ischemia followed by a 3-hour reperfusion, and 50 µL soybean oil (solvent of NCOQ10) was administered 30 min before cessation of reperfusion, group IS/NCOQ10: the procedure included a

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Najafpour, Alireza, та Houman Azizizadeh. "Interaperitoneal Administration of Αlpha-Tocopherol Loaded Nanoparticles Improves Ischemia-Reperfusion Injury in Rat Ovaries Torsion and Detorsion Model". Bulletin of Emergency and Trauma 6, № 3 (2018): 207–16. http://dx.doi.org/10.29252/beat-060304.

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10

Feugang, J. M., R. C. Youngblood, S. T. Willard, and P. L. Ryan. "147 POTENTIAL USE OF CONJUGATED QUANTUM DOT NANOPARTICLES FOR BIO-LABELLING OF MAMMALIAN GAMETES." Reproduction, Fertility and Development 26, no. 1 (2014): 187. http://dx.doi.org/10.1071/rdv26n1ab147.

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Quantum dot nanoparticles (QD) have unique optical properties and high photo-stability. In our previous study, we reported the ability of boar spermatozoa and ovarian follicles to incorporate QD coated with light emitting protein luciferase (QD-BRET) for successful bioluminescence and fluorescence imaging. These reports indicated that co-incubation of QD-BRET with spermatozoa before IVF of pig oocytes does not affect their fertilizing potential, and neither microinjected QD-BRET into cultured porcine ovarian follicles affected their development (Feugang et al. 2012 Reprod. Fertil. Dev.). In th

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Sribna, Valentyna O., Oksana N. Kaleynykova, Natalia G. Grushka, Taras V. Blashkiv, Tetyana Yu Voznesenska, and Roman I. Yanchiy. "Resumption of meiotic maturation of oocytes, pre- and post-implantation mortality of embryos under ten-time intravenous treatment of silver nanoparticles in mice." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 11 (2018): 4360. http://dx.doi.org/10.18203/2320-1770.ijrcog20184478.

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Background: In recent years the use of silver nanoparticles (AgNP) has increased significantly being focused on assessing human health and environmental risks of nanotechnology.Methods: Research (two series) has been done on white laboratory mice. One dose (20 mg/kg) has been investigated. Frequency of treatment: one time per day for 10 times. Material for the study (ovaries, tubes and uterus) was taken under anesthetic anesthesia on the 10/11th, 21/22nd, 33/34th, 42/43rd days (after the last treatment). Oocyte meiotic maturation, pre- and post-implantation mortality of embryos under ten-time

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12

Lytvynenko, Alina P., Ludmila S. Rieznichenko, Valentine A. Sribna, et al. "Functional status of reproductive system under treatment of silver nanoparticles in female mice." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 5 (2017): 1713. http://dx.doi.org/10.18203/2320-1770.ijrcog20171930.

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Background: The use of silver nanoparticles (AgNP) has increased very significantly in recent years the work in science is currently on focused on assessing human health and environmental risks of nanotechnology. The aim of the present study was to estimate the functional status of the female reproductive system in mice under condition of the intravenous treatment of silver nanoparticles (AgNPs), namely to assess meiotic maturation of oocytes, viability of follicular cells surrounding the oocyte, spontaneous contractile activity of the myometrium and pre-and post-implantation mortality of embr

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13

Roy, Pantu-Kumar, Ahmad-Yar Qamar, Bereket-Molla Tanga, et al. "Modified Spirulina maxima Pectin Nanoparticles Improve the Developmental Competence of In Vitro Matured Porcine Oocytes." Animals 11, no. 9 (2021): 2483. http://dx.doi.org/10.3390/ani11092483.

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Molecular approaches have been used to determine metabolic substrates involved in the early embryonic processes to provide adequate culture conditions. To investigate the effect of modified Spirulina maxima pectin nanoparticles (MSmPNPs) on oocyte developmental competence, cumulus–oocyte complexes (COCs) retrieved from pig slaughterhouse ovaries were subjected to various concentrations of MSmPNPs (0, 2.5, 5.0, and 10 µg/mL) during in vitro maturation (IVM). In comparison to the control, MSmPNPs-5.0, and MSmPNPs-10 groups, oocytes treated with 2.5 µg/mL MSmPNPs had significantly increased gluta

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14

Ariu, F., L. Bogliolo, A. Pinna, et al. "Cerium oxide nanoparticles (CeO2 NPs) improve the developmental competence of in vitro-matured prepubertal ovine oocytes." Reproduction, Fertility and Development 29, no. 5 (2017): 1046. http://dx.doi.org/10.1071/rd15521.

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The present study investigated whether supplementation with different doses of cerium dioxide nanoparticles (CeO2 NPs) during in vitro maturation (IVM) of prepubertal ovine oocytes influenced their embryonic development in vitro. Cumulus–oocyte complexes derived from the ovaries of slaughtered prepubertal sheep underwent IVM with CeO2NPs (0, 44, 88 or 220 µg mL–1). Matured oocytes were fertilised in vitro and zygotes were cultured for 7 days. The results demonstrated that CeO2NPs were internalised in the cumulus cells and not in the oocyte. The treatment with CeO2NPs did not affect nuclear mat

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Cabezas, J., D. Rojas, B. Melo-Baez, M. Gutierrez, F. Castro, and L. Rodriguez-Alvarez. "52 Blocking of embryonic development by nanoparticles derived from endometrial and oviductal cells isolated with an Amicon filter system." Reproduction, Fertility and Development 32, no. 2 (2020): 151. http://dx.doi.org/10.1071/rdv32n2ab52.

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The success of development of invitro embryo production needs to mimic culture conditions in the maternal environment. Recently, it has been seen that extracellular vesicles (EVs) secreted by oviducal or endometrial cells may improve development and quality of embryos produced invitro. Extracellular vesicles are a mechanism of cellular communication; they carry molecules that are delivered into the target cells changing gene expression and function. Due to the size range and characteristics of EVs, they require specific methods for purification and characterisation. However, the possible conta

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Aghamiri, Shahin, Keyvan Fallah Mehrjardi, Sasan Shabani, Mahsa Keshavarz-Fathi, Saeed Kargar, and Nima Rezaei. "Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy?" Nanomedicine 14, no. 15 (2019): 2083–100. http://dx.doi.org/10.2217/nnm-2018-0379.

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Ovarian cancer is one of the most common causes of mortality throughout the world. Unfortunately, chemotherapy has failed to cure advanced cancers developing multidrug resistance (MDR). Moreover, it has critical side effects because of nonspecific toxicity. Thanks to specific silencing of oncogenes and MDR-associated genes, nano-siRNA drugs can be a great help address the limitations of chemotherapy. Here, we review the current advances in nanoparticle-mediated siRNA delivery strategies such as polymeric- and lipid-based systems, rigid nanoparticles and nanoparticles coupled to specific ligand

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17

Levit, Shani L., and Christina Tang. "Polymeric Nanoparticle Delivery of Combination Therapy with Synergistic Effects in Ovarian Cancer." Nanomaterials 11, no. 4 (2021): 1048. http://dx.doi.org/10.3390/nano11041048.

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Treatment of ovarian cancer is challenging due to late stage diagnosis, acquired drug resistance mechanisms, and systemic toxicity of chemotherapeutic agents. Combination chemotherapy has the potential to enhance treatment efficacy by activation of multiple downstream pathways to overcome drug resistance and reducing required dosages. Sequence of delivery and the dosing schedule can further enhance treatment efficacy. Formulation of drug combinations into nanoparticles can further enhance treatment efficacy. Due to their versatility, polymer-based nanoparticles are an especially promising tool

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18

Sun, Zhe, Jinhai Huang, Linjia Su, et al. "Arf6-mediated macropinocytosis-enhanced suicide gene therapy of C16TAB-condensed Tat/pDNA nanoparticles in ovarian cancer." Nanoscale 13, no. 34 (2021): 14538–51. http://dx.doi.org/10.1039/d1nr03974a.

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The cellular uptake of C16TAB-condensed Tat/pDNA nanoparticles (Tat/pDNA/C16TAB, T–P–C) was controlled by Arf6-dependent, Rab-activated macropinocytosis, which promoted T–P–C nanoparticle-based suicide gene therapy of ovarian cancer.

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19

Fraguas-Sánchez, Ana I., Ana I. Torres-Suárez, Marie Cohen, et al. "PLGA Nanoparticles for the Intraperitoneal Administration of CBD in the Treatment of Ovarian Cancer: In Vitro and In Ovo Assessment." Pharmaceutics 12, no. 5 (2020): 439. http://dx.doi.org/10.3390/pharmaceutics12050439.

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The intraperitoneal administration of chemotherapeutics has emerged as a potential route in ovarian cancer treatment. Nanoparticles as carriers for these agents could be interesting by increasing the retention of chemotherapeutics within the peritoneal cavity. Moreover, nanoparticles could be internalised by cancer cells and let the drug release near the biological target, which could increase the anticancer efficacy. Cannabidiol (CBD), the main nonpsychotropic cannabinoid, appears as a potential anticancer drug. The aim of this work was to develop polymer nanoparticles as CBD carriers capable

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20

Sribna, V. A., A. P. Litvinenko, L. S. Reznichenko, et al. "Functional state of the ovaries, uterus, thymus and lymph nodes in conditions of experimental immune complex-mediated inflammation and administration of the zero valent iron nanoparticles substance in mice." Problemy reproduktsii 22, no. 4 (2016): 20. http://dx.doi.org/10.17116/repro201622420-27.

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21

Levit, Shani L., Narendar Reddy Gade, Thomas D. Roper, Hu Yang, and Christina Tang. "Self-Assembly of pH-Labile Polymer Nanoparticles for Paclitaxel Prodrug Delivery: Formulation, Characterization, and Evaluation." International Journal of Molecular Sciences 21, no. 23 (2020): 9292. http://dx.doi.org/10.3390/ijms21239292.

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The efficacy of paclitaxel (PTX) is limited due to its poor solubility, poor bioavailability, and acquired drug resistance mechanisms. Designing paclitaxel prodrugs can improve its anticancer activity and enable formulation of nanoparticles. Overall, the aim of this work is to improve the potency of paclitaxel with prodrug synthesis, nanoparticle formation, and synergistic formulation with lapatinib. Specifically, we improve potency of paclitaxel by conjugating it to α-tocopherol (vitamin E) to produce a hydrophobic prodrug (Pro); this increase in potency is indicated by the 8-fold decrease in

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Cruz, Adriana, Pedro Mota, Cristiano Ramos, et al. "Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine Sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance." Antioxidants 9, no. 2 (2020): 133. http://dx.doi.org/10.3390/antiox9020133.

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Ovarian cancer is a highly lethal disease, mainly due to chemoresistance. Our previous studies on metabolic remodeling in ovarian cancer have supported that the reliance on glutathione (GSH) bioavailability is a main adaptive metabolic mechanism, also accounting for chemoresistance to conventional therapy based on platinum salts. In this study, we tested the effects of the in vitro inhibition of GSH synthesis on the restoration of ovarian cancer cells sensitivity to carboplatin. GSH synthesis was inhibited by exposing cells to l-buthionine sulfoximine (l-BSO), an inhibitor of γ-glutamylcystein

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23

Zhang, Chunyan, Xueqing Li, Shuangling Jin, et al. "The Anti-Proliferative Effect of Flavonoid Nanoparticles on the Human Ovarian Cancer Cell Line SK0V3." Journal of Nanoscience and Nanotechnology 20, no. 10 (2020): 6040–46. http://dx.doi.org/10.1166/jnn.2020.18119.

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To investigate the anti-proliferative effect of flavonoid nanoparticles on the human ovarian cancer cell line SKOV3. Ten nude mice were intraperitoneally inoculated with the human ovarian cancer SKOV3 cell mixture. The treatment group received tail vein injections with 1.25 mg/kg of flavonol, once every 3 days, 0.2 mL each time, for a total of 12 times. The control group was a tumor model that was injected with 50 mL/L glucose solution; it was observed in Lacquerin Group as the Laccase Nanoparticle Group. Tumor quality was recorded after treatment. The morphology of tumor cells in the two grou

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Levit, Shani L., Hu Yang, and Christina Tang. "Rapid Self-Assembly of Polymer Nanoparticles for Synergistic Codelivery of Paclitaxel and Lapatinib via Flash NanoPrecipitation." Nanomaterials 10, no. 3 (2020): 561. http://dx.doi.org/10.3390/nano10030561.

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Taxol, a formulation of paclitaxel (PTX), is one of the most widely used anticancer drugs, particularly for treating recurring ovarian carcinomas following surgery. Clinically, PTX is used in combination with other drugs such as lapatinib (LAP) to increase treatment efficacy. Delivering drug combinations with nanoparticles has the potential to improve chemotherapy outcomes. In this study, we use Flash NanoPrecipitation, a rapid, scalable process to encapsulate weakly hydrophobic drugs (logP < 6) PTX and LAP into polymer nanoparticles with a coordination complex of tannic acid and iron forme

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K., Madhumithra S., Balashanmugam P., Mosachristas K., Tamil Selvi A., and Subashini R. "IN VITRO CYTOTOXICITY OF BIOSYNTHESIZED GOLD NANOPARTICLES FROM SHELLS OF PISTACIA VERA L." International Journal of Applied Pharmaceutics 10, no. 4 (2018): 162. http://dx.doi.org/10.22159/ijap.2018v10i4.27154.

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Objective: To synthesize the gold nanoparticles by a biological method using the extract obtained from the shells of Pistacia vera (P. vera) and to study its effective role in the anticancer activity.Methods: The synthesis of gold nanoparticles using the extract obtained from the shells of Pistacia vera was confirmed by the color change and substantiating the same using ultraviolet (UV) visible spectroscopy. The size and the shape of the particles were studied using field emission scanning electron microscopy (FESEM). The stability of the nanoparticles was assessed by using the UV visible spec

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Davis, Michelle. "A Comprehensive Review of the Diagnostic and Treatment Methods for Ovarian Cancer." European Journal of Engineering Research and Science 3, no. 2 (2018): 13. http://dx.doi.org/10.24018/ejers.2018.3.2.555.

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Ovarian cancer is amongst the most life-threatening malignancy of the female reproductive system, whereas 90% of those ovarian cancers are epithelial with an overall poor five-year survival rate of 44% across all stages and all races [1]–[2], [31]. This paper aims to review the current treatment and diagnostic strategies for ovarian cancer [3]. Using grounded substantial research, multiple figures were developed to show the relations of ovarian cancer diagnostics and ovarian cancer therapeutics. It is a great start to look into what may be causing most patients to become resistant to the curre

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Ganesh, G. N. K., Vianni Chopra, Veera Venkata Satyanarayana Reddy Karri, S. Kiran Koundinya, R. Suresh Kumar, and R. Arun. "Development and Characterization of Core–Shell Nanoparticles for Anticancer Therapy." Advanced Science Letters 24, no. 8 (2018): 5768–77. http://dx.doi.org/10.1166/asl.2018.12194.

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Gemcitabine hydrophilic used for the treatment of solid tumours like ovarian, breast, bladder and small-cell lung cancer, pancreatic cancer. In year 1996 FDA approved it for breast cancer treatment but it has a drawback of rapid body clearance by kidney and metabolism by the plasmatic enzyme cytidine-deaminase. The aim of the study is to entrap gemcitabine in Core–Shell nanoparticles which acts an efficient carrier system for increasing drug’s efficacy. Gemcitabine loaded with BSA-PLGA core shell Nanoparticle prepared by double emulsion-solvent diffusion evaporation method using a ratio optimi

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Guo, Jinzhu, Hua Yue, Yanjun Wang, and Xiujuan Du. "Evaluation Preparation of Apatinib-Loaded Polymer Nanoparticles and Its Effect in the Treatment of Advanced Ovarian Cancer." Journal of Nanoscience and Nanotechnology 21, no. 2 (2021): 1212–19. http://dx.doi.org/10.1166/jnn.2021.18669.

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Ovarian cancer is a common gynecological malignant tumor, second only to cervical cancer and uterine body cancer. In China, ovarian cancer has the highest mortality rate in gynecological tumors. Due to the rapid spread of cancer cells, the prognosis is relatively poor. Because the ovarian epithelial cancer is relatively insidious, there are no obvious clinical manifestations in the early stage. At present, apatinib chemotherapy is widely used, which can reduce the disease of patients by inhibiting the migration and proliferation of vascular endothelial cells. Fluorescence imaging is widely use

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Chatterjee, Nilanjana, and Baibaswata Bhattacharjee. "Revelation of ZnS Nanoparticles Induces Follicular Atresia and Apoptosis in the Ovarian Preovulatory Follicles in the CatfishMystus tengara(Hamilton, 1822)." Scientifica 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/3927340.

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Important physicochemical characteristics of water like dissolved oxygen content, pH, and so forth were found to change in a dose dependent manner, showing a negative correlation with the nanoparticle concentration, when ZnS nanoparticle (NP) was exposed to water. This observation could be attributed to the enhanced photooxidation property associated with ZnS in its NP form. Under this situation, the catfishMystus tengarawas forced to live in hypoxia in its habitat. This condition was found to hamper the natural oogenesis process of the fish. Due to exposure at relatively lower concentration o

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Liu, Bing, Jian Zhou, Bin Zhang, and Jing Qu. "Synthesis of Ag@Fe3O4 Nanoparticles for Photothermal Treatment of Ovarian Cancer." Journal of Nanomaterials 2019 (January 28, 2019): 1–6. http://dx.doi.org/10.1155/2019/6457968.

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Photothermal therapy is a promising approach for cancer treatment. In our study, we investigate the photothermal effect of different concentrations of the Ag@Fe3O4 nanoparticles on apoptosis and proliferation in the human epithelial ovarian cancer cells SKOV3. Ovarian cancer cells SKOV3 were treated with the Ag@Fe3O4 nanoparticles under an 808 nm near-infrared (NIR) laser irradiation at different concentrations. The cell proliferation was measured by the cell counting kit-8 (CCK-8) assay. The results show that the Ag@Fe3O4 nanoparticles with NIR laser irradiation could markedly inhibit the pro

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Mohammadi Ghalaei, Parviz, Jaleh Varshosaz, and Hojatollah Sadeghi Aliabadi. "Evaluating Cytotoxicity of Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide on SK-OV-3 Cells." Journal of Drug Delivery 2014 (April 24, 2014): 1–7. http://dx.doi.org/10.1155/2014/746325.

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The epithelial ovarian carcinoma is one of the most fatal gynecological cancers. Etoposide is used in treating platinum-resistant ovarian cancer. Sodium hyaluronate is a substance that binds to the CD44 receptors overexpressed in SK-OV-3 cells of epithelial ovarian carcinoma. The aim of the present work was to study the cytotoxicity effect of hyaluronate targeted solid lipid nanoparticles (SLNs) of etoposide on SK-OV-3 cells. The cytotoxicity of the targeted and nontargeted SLNs of etoposide was compared to free drug on the SK-OV-3 cells by MTT assay method. The cellular uptake of the targeted

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Gawęda, Weronika, Marek Pruszyński, Edyta Cędrowska, et al. "Trastuzumab Modified Barium Ferrite Magnetic Nanoparticles Labeled with Radium-223: A New Potential Radiobioconjugate for Alpha Radioimmunotherapy." Nanomaterials 10, no. 10 (2020): 2067. http://dx.doi.org/10.3390/nano10102067.

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Barium ferrite nanoparticles (BaFeNPs) were investigated as vehicles for 223Ra radionuclide in targeted α-therapy. BaFe nanoparticles were labeled using a hydrothermal Ba2+ cations replacement by 223Ra with yield reaching 61.3 ± 1.8%. Radiolabeled nanoparticles were functionalized with 3-phosphonopropionic acid (CEPA) linker followed by covalent conjugation to trastuzumab (Herceptin®). Thermogravimetric analysis and radiometric method with the use of [131I]-labeled trastuzumab revealed that on average 19–21 molecules of trastuzumab are attached to the surface of one BaFe–CEPA nanoparticle. The

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Santacruz-Márquez, Ramsés, Marijose González-De los Santos, and Isabel Hernández-Ochoa. "Ovarian toxicity of nanoparticles." Reproductive Toxicology 103 (August 2021): 79–95. http://dx.doi.org/10.1016/j.reprotox.2021.06.002.

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Howard, David, Jetzabel Garcia-Parra, Gareth D. Healey, et al. "Antibody–drug conjugates and other nanomedicines: the frontier of gynaecological cancer treatment." Interface Focus 6, no. 6 (2016): 20160054. http://dx.doi.org/10.1098/rsfs.2016.0054.

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Gynaecological cancers: malignancies of the cervix, uterus, ovaries, vagina and vulva, are responsible for over 1.1 million new cancer cases and almost half a million deaths annually. Ovarian cancer in particular is difficult to treat due to often being diagnosed at a late stage, and the incidence of uterine and vulvar malignancies are both on the rise. The field of nanomedicine is beginning to introduce drugs into the clinic for oncological applications exemplified by the liposomal drugs, Doxil and Myocet, the nanoparticle, Abraxane and antibody–drug conjugates (ADCs), Kadcyla and Adcetris. W

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Fraguas Sánchez, Ana Isabel, Ana Isabel Torres Suárez, and Ana Fernández Carballido. "CANNABINOID BASED CHEMO-NANOTHERAPY FOR THE TREATMENT OF GYNECOLOGICAL MALIGNANCIES." Anales de la Real Academia Nacional de Farmacia, no. 86(02) (2020): 133–50. http://dx.doi.org/10.53519/analesranf.2020.86.02.05.

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Cannabidiol has become in a potential anticancer agent. Nevertheless, it has not been evaluated in ovarian cancer, one of the most aggressive tumors in women. In this work, the potential use of cannabidiol in solution and encapsulated into polymeric nanoparticles coated with folic acid was evaluated for the first time for the treatment of ovarian cancer. Ovarian tumors over-express folic acid receptors and folic-acid-coated nanoformulations trend to be selectively accumulated at tumor site. Cannabidiol in solution administered as monotherapy inhibits the proliferation and migration of SKOV-3 c

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Protsenko, O. V., Ya Yasinskiy, I. I. Horiunova, et al. "Evaluation of toxicity and genotoxicity of nano nanoparticles Ag2S, synthesised by biological matrix, on Drosophila melanogaster Mg. (Diptera: Drosophilidae)." Faktori eksperimental'noi evolucii organizmiv 23 (September 9, 2018): 114–19. http://dx.doi.org/10.7124/feeo.v23.999.

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Aim. To evaluate the toxicity and genotoxicity of Ag2S quantum dots that had been synthesized by the mycelium of the fungus Pleurotus ostreatus on Drosophila melanogaster. Methods. The toxicity of nanoparticles was determined by assessing the survival rate of imagos and larvae. Genotoxicity was studied in the reparation test. The influence of nanoparticles on the development of the D. melanogaster reproductive system was determined by evaluating the number of ovariols. Results. The toxic effects of ionic silver and the absence of such effects in biosynthetic Ag2S nanoparticles had been shown.

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Zhang, Shuai, Junhui Liang, Changzhong Li, and Fei Wang. "Effects of nano-taxol/curcumin on ovarian cancer cells." Materials Express 10, no. 10 (2020): 1615–19. http://dx.doi.org/10.1166/mex.2020.1818.

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To investigate the pharmacodynamic effect of urushin nanoparticles upon the proliferation inhibition in human ovarian cancer SKOV3 cells, and in order to explore their biomechanism, the cell cycle and the percentage of apoptotic cells in human ovarian cancer SKOV3 cells were analyzed utilizing flow cytometry. The concentration of astragalin nanoparticles in SKOV3 cells was identified utilizing HPIC. Consequently, the morphological characteristics of SKOV3 cells in a culture medium of 5 mg/L were investigated and measured. In our findings, the 50 mg cancer cells containing 50 mg IC did not disp

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Sirotkin, Alexander V., Richard Alexa, Aneta Stochmalova, and Sona Scsukova. "Plant isoflavones can affect accumulation and impact of silver and titania nanoparticles on ovarian cells." Endocrine Regulations 55, no. 1 (2021): 52–60. http://dx.doi.org/10.2478/enr-2021-0007.

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Abstract Objectives. The application of nanoparticles is experiencing a rapid growth, but it faces a problem of their toxicity, especially adverse effects on female reproduction. Food and medicinal plants and their isoflavones can be protectors against environmental stressors, but their ability to abate the adverse effects of nanoparticles has not been studied yet. In the present study, we examined the effect of silver (AgNPs) and titanium dioxide (titania, TiO2NPs) nanoparticles alone or in combination with plant phytoestrogens/antioxidants (resveratrol, diosgenin, and quercetin) on accumulat

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Zhang, Song, Yu Zhang, Jiwei Liu, Chunhua Zhang, Ning Gu, and Fangqiu Li. "Preparation of Anti-Sperm Protein 17 Immunomagnetic Nanoparticles for Targeting Cell." Journal of Nanoscience and Nanotechnology 8, no. 5 (2008): 2341–46. http://dx.doi.org/10.1166/jnn.2008.084.

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Poly(ethylene glycol) was functionalized with carboxyl groups by esterification with succinic anhydride in the media of dioxane and pyridine as catalyst. Maghemite nanoparticles were synthesized by chemical coprecipitation and coated with carboxylated poly(ethylene glycol) to improve their biocompatibility. And the properties were characterized using Fourier transform infrared spectroscopy, Transmission electronic microscopy, X-ray diffraction, Zeta potential analyzer and Vibrating sample magnetometer. The immunomagnetic nanoparticles were obtained by grafting anti-sperm protein 17 monoclonal

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Halbur, Christopher, Niharika Choudhury, Michael Chen, Jun Hyuk Kim, and Eun Ji Chung. "siRNA-Conjugated Nanoparticles to Treat Ovarian Cancer." SLAS TECHNOLOGY: Translating Life Sciences Innovation 24, no. 2 (2019): 137–50. http://dx.doi.org/10.1177/2472630318816668.

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Ovarian cancer is the fifth-most lethal cancer among women due to a lack of early detection and late-stage treatment options, and it is responsible for more than 14,000 deaths each year in the United States. Recently, there have been advances in RNA interference therapy, specifically with small interfering RNA (siRNA), to reduce tumor burden for ovarian cancer via gene down-regulation. However, delivery of siRNA poses its own challenges, as siRNA is unstable in circulation, is unable to be effectively internalized by cells, and may cause toxicity in off-target sites. To address such challenges

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Zhou, Hang, Jing Fu, Qihuan Fu, et al. "Biotin-streptavidin-guided two-step pretargeting approach using PLGA for molecular ultrasound imaging and chemotherapy for ovarian cancer." PeerJ 9 (May 25, 2021): e11486. http://dx.doi.org/10.7717/peerj.11486.

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Background Ovarian cancer seriously threatens the lives and health of women, and early diagnosis and treatment are still challenging. Pre-targeting is a promising strategy to improve the treatment efficacy of ovarian cancer and the results of ultrasound imaging. Purpose To explore the effects of a pre-targeting strategy using streptavidin (SA) and paclitaxel (PTX)-loaded phase-shifting poly lactic-co-glycolic acid (PLGA) nanoparticles with perfluoro-n-pentane (PTX-PLGA-SA/PFPs) on the treatment and ultrasound imaging of ovarian cancer. Methods PTX-PLGA/PFPs were prepared with a single emulsion

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Dziawer, Łucja, Agnieszka Majkowska-Pilip, Damian Gaweł, et al. "Trastuzumab-Modified Gold Nanoparticles Labeled with 211At as a Prospective Tool for Local Treatment of HER2-Positive Breast Cancer." Nanomaterials 9, no. 4 (2019): 632. http://dx.doi.org/10.3390/nano9040632.

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Highly localized radiotherapy with radionuclides is a commonly used treatment modality for patients with unresectable solid tumors. Herein, we propose a novel α-nanobrachytherapy approach for selective therapy of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. This uses local intratumoral injection of 5-nm-diameter gold nanoparticles (AuNPs) labeled with an α-emitter (211At), modified with polyethylene glycol (PEG) chains and attached to HER2-specific monoclonal antibody (trastuzumab). The size, shape, morphology, and zeta potential of the 5 nm synthesized AuNPs were ch

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Jayawardhana, Amarasooriya M. D. S., Zhihan Qiu, Susan Kempf, et al. "Dual-action organoplatinum polymeric nanoparticles overcoming drug resistance in ovarian cancer." Dalton Transactions 48, no. 33 (2019): 12451–58. http://dx.doi.org/10.1039/c9dt01683j.

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Burns, Joshua M., Elise Shafer, Raviraj Vankayala, Vikas Kundra, and Bahman Anvari. "Near Infrared Fluorescence Imaging of Intraperitoneal Ovarian Tumors in Mice Using Erythrocyte-Derived Optical Nanoparticles and Spatially-Modulated Illumination." Cancers 13, no. 11 (2021): 2544. http://dx.doi.org/10.3390/cancers13112544.

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Ovarian cancer is the deadliest gynecological cancer. Cytoreductive surgery to remove primary and intraperitoneal tumor deposits remains as the standard therapeutic approach. However, lack of an intraoperative image-guided approach to enable the visualization of all tumors can result in incomplete cytoreduction and recurrence. We engineered nano-sized particles derived from erythrocytes that encapsulate the near infrared (NIR) fluorochrome, indocyanine green, as potential imaging probes for tumor visualization during cytoreductive surgery. Herein, we present the first demonstration of the use

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Xu, Guangya, Changhui Zhu, Bin Li, et al. "Improving the Anti-Ovarian Cancer Activity of Docetaxel by Self-Assemble Micelles and Thermosensitive Hydrogel Drug Delivery System." Journal of Biomedical Nanotechnology 16, no. 1 (2020): 40–53. http://dx.doi.org/10.1166/jbn.2020.2867.

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In recent decades, a large number of research studies have been conducted to improve the treatment strategy against epithelial ovarian cancer, but women in advanced stage still have poor outcomes. The development of advanced treatments must be continued to overcome the limitation. Docetaxel, a semi-synthetic product derived from the Pacific Taxus extract, has been studied for many years for its potent anticancer applications. Aiming to solve the problems of its highly lipophilicity, insolubility and adverse side effects, nanocarriers were applied. Relying on the integration of nanoparticles wh

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Liu, Wenting, Liju Nie, Fulai Li, et al. "Folic acid conjugated magnetic iron oxide nanoparticles for nondestructive separation and detection of ovarian cancer cells from whole blood." Biomaterials Science 4, no. 1 (2016): 159–66. http://dx.doi.org/10.1039/c5bm00207a.

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Dang, Xiangnan, Li Gu, Jifa Qi, et al. "Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer." Proceedings of the National Academy of Sciences 113, no. 19 (2016): 5179–84. http://dx.doi.org/10.1073/pnas.1521175113.

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Fluorescence imaging in the second near-infrared window (NIR-II, 1,000–1,700 nm) features deep tissue penetration, reduced tissue scattering, and diminishing tissue autofluorescence. Here, NIR-II fluorescent probes, including down-conversion nanoparticles, quantum dots, single-walled carbon nanotubes, and organic dyes, are constructed into biocompatible nanoparticles using the layer-by-layer (LbL) platform due to its modular and versatile nature. The LbL platform has previously been demonstrated to enable incorporation of diagnostic agents, drugs, and nucleic acids such as siRNA while providin

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Sirotkin, Alexander V., Monika Radosová, Adam Tarko, Zuzana Fabova, Iris Martín-García, and Francisco Alonso. "Abatement of the Stimulatory Effect of Copper Nanoparticles Supported on Titania on Ovarian Cell Functions by Some Plants and Phytochemicals." Nanomaterials 10, no. 9 (2020): 1859. http://dx.doi.org/10.3390/nano10091859.

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The application of nanoparticles has experienced a vertiginous growth, but their interaction with food and medicinal plants in organisms, especially in the control of reproduction, remains unresolved. We examined the influence of copper nanoparticles supported on titania (CuNPs/TiO2), plant extracts (buckwheat (Fagopyrum esculentum) and vitex (Vitex agnus-castus)), phytochemicals (rutin and apigenin), and their combination with CuNPs/TiO2 on ovarian cell functions, using cultured porcine ovarian granulosa cells. Cell viability, proliferation (PCNA accumulation), apoptosis (accumulation of bax)

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Haber, Tom, Yvonne R. Cornejo, Soraya Aramburo, et al. "Specific targeting of ovarian tumor-associated macrophages by large, anionic nanoparticles." Proceedings of the National Academy of Sciences 117, no. 33 (2020): 19737–45. http://dx.doi.org/10.1073/pnas.1917424117.

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Immunotherapy is emerging as one of the most effective methods for treating many cancers. However, immunotherapy can still introduce significant off-target toxicity, and methods are sought to enable targeted immunotherapy at tumor sites. Here, we show that relatively large (>100-nm) anionic nanoparticles administered intraperitoneally (i.p.) selectively accumulate in tumor-associated macrophages (TAMs). In a mouse model of metastatic ovarian cancer, fluorescently labeled silica, poly(lactic-co-glycolic acid), and polystyrene nanoparticles administered i.p. were all found to selectively accu

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Deng, Yang, Fan Yang, Emiliano Cocco, et al. "Improved i.p. drug delivery with bioadhesive nanoparticles." Proceedings of the National Academy of Sciences 113, no. 41 (2016): 11453–58. http://dx.doi.org/10.1073/pnas.1523141113.

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The i.p. administration of chemotherapy in ovarian and uterine serous carcinoma patients by biodegradable nanoparticles may represent a highly effective way to suppress peritoneal carcinomatosis. However, the efficacy of nanoparticles loaded with chemotherapeutic agents is currently hampered by their fast clearance by lymphatic drainage. Here, we show that a unique formulation of bioadhesive nanoparticles (BNPs) can interact with mesothelial cells in the abdominal cavity and significantly extend the retention of the nanoparticles in the peritoneal space. BNPs loaded with a potent chemotherapeu

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