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Journal articles on the topic 'Over conventional drug delivery'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Batur, Eslim, Samet Özdemir, Meltem Ezgi Durgun, and Yıldız Özsoy. "Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery." Pharmaceuticals 17, no. 4 (2024): 511. http://dx.doi.org/10.3390/ph17040511.

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Ocular drug delivery poses unique challenges due to the complex anatomical and physiological barriers of the eye. Conventional dosage forms often fail to achieve optimal therapeutic outcomes due to poor bioavailability, short retention time, and off-target effects. In recent years, vesicular drug delivery systems have emerged as promising solutions to address these challenges. Vesicular systems, such as liposome, niosome, ethosome, transfersome, and others (bilosome, transethosome, cubosome, proniosome, chitosome, terpesome, phytosome, discome, and spanlastics), offer several advantages for oc

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2

Iqbal, Zeenat, and Fahima Dilnawaz. "Nanocarriers For Vaginal Drug Delivery." Recent Patents on Drug Delivery & Formulation 13, no. 1 (2019): 3–15. http://dx.doi.org/10.2174/1872211313666190215141507.

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Background:Vaginal drug delivery approach represents one of the imperative strategies for local and systemic delivery of drugs. The peculiar dense vascular networks, mucus permeability, and range of physiological characteristics of the vaginal cavity have been exploited for therapeutic benefit. Furthermore, the vaginal drug delivery has been curtailed due to the influence of different physiological factors like acidic pH, constant cervical secretion, microflora, cyclic changes during periods along with turnover of mucus of varying thickness.Objective:This review highlights advancement of nanom

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Gupta, Brahma Prakash, Navneet Thakur, Nishi P. Jain, Jitendra Banweer, and Surendra Jain. "Osmotically Controlled Drug Delivery System with Associated Drugs." Journal of Pharmacy & Pharmaceutical Sciences 13, no. 4 (2010): 571. http://dx.doi.org/10.18433/j38w25.

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Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain mole

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Dharmeh, Trivedi, and Goyal Anju. "Pros and Cons of Transdermal Drug Delivery System." Pharmaceutical and Chemical Journal 7, no. 4 (2020): 53–60. https://doi.org/10.5281/zenodo.13955283.

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Transdermal drug delivery is having variety of benefits over traditional drug delivery systems and has increased patient compliance. Transdermal patches are easy application on skin and removal as and when required. TDDS deliver drugs for systemic effects at a predetermined and controlled rate over an extended period of time in order to enhance the therapeutic effectiveness and reduce adverse effect of the drug. TDDS helps in maintaining the concentration of drug within the therapeutic window range for extended time period ensuring that drug levels should not fall below the minimum effective c

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Saini, Madhurima, Dr Shiv Garg, Dr Piush Sharma, and Dr Shailendra Bhatt. "New Insights in Topical Drug Delivery for Skin Disorders: A Review." Asian Journal of Pharmaceutical Research and Development 12, no. 2 (2024): 107–14. http://dx.doi.org/10.22270/ajprd.v12i2.1323.

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Drug delivery systems are methods which are used to ensure that drugs get into the body and reach the area where they are needed. These systems must take a number of needs into account, ranging from ease of delivery to effectiveness of the drugs. The paper reviews an overview of a conventional and novel approach in the topical drug delivery system. Drug delivery via the skin is becoming progressively popular due to its convenience and affordability. The skin is the most important mechanical barrier to the penetration of many drug substances and acts as an ideal site to deliver the drug both lo

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Anitha, P., J. Bhargavi, G. Sravani, B. Aruna, and Ramkanth S. "RECENT PROGRESS OF DENDRIMERS IN DRUG DELIVERY FOR CANCER THERAPY." International Journal of Applied Pharmaceutics 10, no. 5 (2018): 34. http://dx.doi.org/10.22159/ijap.2018v10i5.27075.

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With the recent advances of nanotechnology, dendrimers are emerging as a highly attractive class of drug delivery vectors for cancer therapy. Dendrimers are multifunctional smart Nanocarriers to deliver one or more therapeutic agent safely and selectively to cancer cells. The high level of control over the synthesis of dendritic architecture makes dendrimers a nearly perfect (spherical) nanocarrier for site-specific drug delivery. The presence of functional groups in the dendrimers exterior also permits the addition of other moieties that can actively target certain diseases which are now wide

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Rao, Tadikonda Rama, Billa Sravani, and Ratnapuram Aarthi. "Nanocarriers in Drug Delivery Systems: An Overview." Journal of Advanced Scientific Research 16, no. 03 (2025): 8–14. https://doi.org/10.55218/jasr.2025160302.

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Nanocarriers have emerged as a transformative technology in drug delivery systems (DDS), offering significant advancements over traditional methods. This review delves into the various types of nanocarriers, including liposomes, polymeric nanoparticles, micelles, dendrimers, and solid lipid nanoparticles, highlighting their unique properties and advantages in targeted drug delivery. Liposomes have demonstrated extraordinary effectiveness in clinical applications due to their biocompatibility. Conversely, polymeric nanoparticles offer improved stability and regulated drug release, which makes t

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Bornare, Swapnil S., Smita S. Aher, and Ravindranath B. Saudagar. "A REVIEW: FILM FORMING GEL NOVEL DRUG DELIVERY SYSTEM." International Journal of Current Pharmaceutical Research 10, no. 2 (2018): 25. http://dx.doi.org/10.22159/ijcpr.2018v10i2.25886.

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Film forming gels are a novel approach in this area that might present an alternative to the conventional dosage forms used on the skin, such as ointments, creams, gels or patches. The polymeric solution is applied to the skin as a liquid and forms an almost invisible film in situ by solvent evaporation. Transdermal drug delivery system (TDDS) and dermal drug delivery system can provide some desirable performances over conventional pharmaceutical dosage formulations, such as avoiding gut and hepatic first-pass metabolism, improving drug bioavailability, reducing dose frequency and stabilizing

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9

K. Shewale, Avani, Akshay R. Yadav, and Ashwini S. Jadhav. "Novel Drug Delivery Systems and its Future Prospects." Journal of University of Shanghai for Science and Technology 24, no. 1 (2022): 48–60. http://dx.doi.org/10.51201/jusst/21/121047.

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Most common methods of delivery include the preferred topical (skin), transmucosal (nasal, buccal, sublingual, vaginal, ocular and rectal) and inhalation routes. The conventional dosage forms provide drug release immediately and it causes fluctuation of drug level in blood depending upon dosage form. Therefore to maintain the drug concentration within therapeutically effective range needs novel drug delivery system. In the past few decades, considerable attention has been focused on the development of novel drug delivery system (NDDS). The NDDS should ideally fulfill two prerequisites. Firstly

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10

S.K, Ghate Dr. D.M.Sakarkar. "DEVELOPMENT AND EVALUATION OF OSMOTICALLY CONTROLLED ORAL DRUG DELIVERY SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 459–70. https://doi.org/10.5281/zenodo.1036415.

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Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentrations. Drugs can be delivered in a controlled pattern over a long period of time by the controlled or modified release drug delivery systems. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain mole

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11

Karmakar, Shaswata, Shashikiran Shanmugasundaram, and Baishakhi Modak. "Oleogel-based drug delivery for the treatment of periodontitis: current strategies and future perspectives." F1000Research 12 (September 27, 2023): 1228. http://dx.doi.org/10.12688/f1000research.140173.1.

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Periodontitis is the chronic inflammation of tooth-supporting tissues that leads to loss of tooth support if untreated. Conventional therapy for periodontitis (mechanical removal of microbial biofilm and oral hygiene enforcement) is augmented by anti-microbial and anti-inflammatory drugs. These drugs are frequently delivered locally into the periodontal pocket for maximum efficiency and minimum adverse effects. The potential of oleogels for periodontal drug delivery has been discussed and further, the future scope of oleogel-based drug delivery systems in dentistry. An oleogel-based local drug

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Priyanka, Priyanka, Rizwana Khan Rizwana Khan, and Bhawna Sharma Bhawna Sharma. "A Review on Transdermal Patch." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 518–29. https://doi.org/10.35629/4494-1003518529.

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Transdermal drug delivery (TDDS) is one of the most promising methods for drug application. Increasing numbers of drugs are being added to the list of therapeutic agents that can be delivered to the systemic circulation via the skin. Transdermal patch products were first approved by the FDA in 1981. Transdermal delivery is the most common painless technique of administering drugs to systemic circulation, providing controlled, constant administration of the drug, allowing continuous input of drugs with short biological half-lives, and eliminating pulsed entry into the systemic circulation. A tr

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Haranath, Chinthaginjala. "Recent advances in lipid based nanovesicles for transdermal drug delivery." Journal of medical pharmaceutical and allied sciences 11, no. 6 (2022): 5375–81. http://dx.doi.org/10.55522/jmpas.v11i6.4273.

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Lipid based nanovesicles are the formulations which are used for the delivery of hydrophilic, hydrophobic and amphiphilic drugs or compounds. They are very helpful for the drugs which are hydrophilic and irritant drugs that can be encapsulated and delivered to the target site. They are very advantageous over conventional formulations. Lipid based nanovesicular systems will efficaciously help the drugs addressing the issues of solubility and penetration thereby promotes bioavailability. Now a days lipid based nanovesicles for transdermal delivery of drug has become very useful especially for hy

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Dobhal, Nidhi* Mukhopadhyay Sayantan. "TRANSDERMAL DRUG DELIVERY –ITS APPROACHES, UTILITY AND CURRENT ADVANCEMENT." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 3751–60. https://doi.org/10.5281/zenodo.1247455.

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Transdermal drug delivery system comprises one of the most important routes for new drug delivery system. Providing a means to sustain drug release it offers a large number of advantages over conventional drug delivery system. These are self-contained, discrete dosage forms which are known to deliver drug through intact skin at a controlled rate into systemic circulation. This delivery system has undergone a large number of modifications since its introduction in 1800’s, starting from the first generation which included delivery of small, lipophilic, low dose drugs to later ones which ta

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Prajapat, Priyanka, Dilip Agrawal, and Gaurav Bhaduka. "A brief overview of sustained released drug delivery system." Journal of Applied Pharmaceutical Research 10, no. 3 (2022): 05–11. http://dx.doi.org/10.18231/j.joapr.2022.10.3.5.11.

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The most popular and patient-friendly method of drug administration is often thought to be the oral route of administration. Compared to conventional release formulations, advancements in formulation technology, including modified release dosage forms or sustained release oral dosage forms, have been extensively accepted. A sustained release dosage form provides a prolonged release of the drug over an extended period, thereby giving better patient compliance and enhanced bioavailability. Sustain release systems are considered a wiser approach for drugs with short half-lives requiring repeated

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Pakhale, Priyanka, M. D. Touhid Ansari, Deepanshu Gupta, et al. "Boswellia Serrata-Infused Transdermal Patches: A Promising Therapy for Arthritis." International Journal of Advanced Multidisciplinary Research and Studies 5, no. 3 (2025): 1002–9. https://doi.org/10.62225/2583049x.2025.5.3.4399.

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Chronic joint inflammatory conditions like osteoarthritis and rheumatoid arthritis share common features, including increased inflammation and oxidative stress, which lead to ongoing tissue damage and debilitating symptoms. In conventional medicine, the oral route is commonly used, but it often fails to produce the desired effects due to systemic circulation and first-pass metabolism, which can delay the drug’s bioavailability and therapeutic action. In contrast, transdermal drug delivery has made a significant impact in medical practice. This method involves a medicated patch that delivers a

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Rajput, Rajesh, K. M. K. Prasanna Kumar, D. S. Arya, et al. "Osmotic controlled drug delivery system (OSMO technology) and its impact on diabetes care." International Journal of Research in Medical Sciences 9, no. 1 (2020): 303. http://dx.doi.org/10.18203/2320-6012.ijrms20205861.

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Recently, focus on the development of controlled release drug delivery system has increased, as existing drugs exhibit certain pharmacokinetic limitations. The major goal of designing sustained release formulations is to improve the drug performance by prolonged duration of drug action, decreased frequency of dosing and reduced side effects by using smallest quantity of drug administered by the most suitable route. Osmotic-controlled release oral delivery system (OSMO technology) is the most promising strategy based system for sustained delivery of drug. Drug can be delivered in a controlled m

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18

Kharia, A., R. Gilhotra, and A. K. Singhai. "Overview of Transdermal Medicated Patches with its research updates in preceding years." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 1094–102. http://dx.doi.org/10.22270/jddt.v9i3-s.2962.

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Innovations in transdermal drug delivery systems (TDDS) is an important influence to medical practice by providing advances in the delivery of treatment with existing conventional drugs and novel drugs. Transdermal drug delivery is one of the most promising methods for drug application. It has several benefits over conventional system to offer sustained drug release, avoidance of first pass effect, patient compliance, ease of application and removal in case of toxicity as well as decrease in the side effects as compared with conventional therapy. Transdermal patches are dosage forms which tran

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19

Shripal, Kolsure Dr. Shivappa Nagoba* Atiya Shaikh Akshay Babhulkar Harshada Ghuge Chakradhar Mohite. "Ethosomes: A Novel Vesicular Carrier for Enhanced Transdermal Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 5057–69. https://doi.org/10.5281/zenodo.15558781.

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Transdermal drug delivery systems (TDDS) offer significant advantages over traditional drug delivery methods but face limitations due to the skin's barrier properties, particularly with conventional liposomal formulations. Ethosomes, a novel lipid-based vesicular carrier system containing high concentrations of ethanol, have emerged as a promising solution. These soft, malleable, and non-invasive vesicles enable deeper skin penetration and systemic drug delivery, overcoming the challenges of the stratum corneum. Ethosomes can effectively deliver both highly lipophilic and cationic drugs such a

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Fateh, Mohd Vaseem, Vikas Kumar, Renu Chaudhary, and Vivak Ujjwal. "Gastro-retentive drug delivery system for treatment of Ulcer." International Journal of Agricultural Invention 3, no. 02 (2019): 203–10. http://dx.doi.org/10.46492/ijai/2018.3.2.18.

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Due to the comfort of administration, economical and extensibility in formulation, the most adopted route to the systemic circulation is the oral route regardless of the astounding elevation in the drug delivery. Oral drug delivery is the most comforting method of delivery due to its comforting method of delivery, due to its better solubility, accurate dosage and simpler production. Approximately 90% of the drugs are administered orally of which solid oral dosage form is the most chosen class of medicaments. Conventional dosage forms usually exhibit the serum drug concentration fluctuations an

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Sharadha M, Gowda D V, Vishal Gupta N, and Akhila A R. "An overview on topical drug delivery system – Updated review." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 368–85. http://dx.doi.org/10.26452/ijrps.v11i1.1831.

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The paper reviews an overview of a conventional and novel approach in the topical drug delivery system. Drug delivery via the skin is becoming progressively popular due to its convenience and affordability. The skin is the most important mechanical barrier to the penetration of many drug substances and acts as an ideal site to deliver the drug both locally and systemically. The topical route has been a favored route of drug administration over the last decades. Despite conventional topical drug delivery systems limits in poor retention and low bioavailability. This drawback overcomes by extens

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Prajakta, Bichkule* Ulka Mote. "A Review Article on Ocular Drug Delivery Advances." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 930–47. https://doi.org/10.5281/zenodo.14204297.

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The human eye is a sophisticated organ with distinctive anatomy and physiology that hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration is an interest of scientists for many decades. Their difficult mission Is to prolong drug residence time and guarantee an appropriate ocular permeation. Several ocular obstacles oppose effective Drug delivery such as precorneal, corneal, and blood-corneal barriers. Routes for ocular delivery include topical, interatrial, intraocular, juxtascleral, subconjunctival, intracameral, and retrobulbar. More than 95% of markete

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Divya, M. Ramchandani* Brijesh R. Humbal and Bhulesh V. Paida. "Role of Nanoparticles in Drug Delivery System." Science World a monthly e magazine 2, no. 11 (2022): 1877–83. https://doi.org/10.5281/zenodo.7358409.

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Nanomedicine and nano delivery systems are new but rapidly developing science which serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Novel drug delivery systems have several advantages over conventional multi dose therapy. Drug designing at the nanoscale has been of its potential advantages such as the possibility to modify properties like solubility, drug release profiles, diffusivity, bioavailability and immunogenicity. Nanoparticles can offer significant advantages in terms of high stability, high specificity, high drug c

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Krupali, Chaudhari* Mansi Dhankani Amitkumar Dhankani Sunil Pawar. "Microspheres: Key Players in Targeted Drug Delivery and Controlled Release." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 2207–16. https://doi.org/10.5281/zenodo.15079731.

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Over the past years, advanced drug delivery systems have become more prominent and crucial in pharmaceutical formulations. Traditional or conventional drug delivery systems have several drawbacks, such as the need for frequent dosing for certain drugs with short half-lives to maintain the desired therapeutic drug concentration in the bloodstream. This frequent dosing requirement leads to poor patient compliance and fluctuations in the drug's developing controlled drug delivery systems. Several methods exist for controlled drug delivery, including liposomes, niosomes, ethosomes, phytosomes, mic

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Suttee, Ashish, Vijay Mishra, Pallavi Nayak, Manvendra Singh, and Pavani Sriram. "Niosomes: Potential Nanocarriers for Drug Delivery." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 11, no. 03 (2020): 389–94. http://dx.doi.org/10.25258/ijpqa.11.3.13.

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Niosomes are novel vesicular drug delivery systems, where the solution is surrounded by non-ionic surfactant vesicles. The niosomes offer different benefits over the traditional drug delivery system. Niosomes are structurally similar to liposomes, as they also consist of a bilayer. In the case of niosomes, the bilayer consists of non-ionic surface-active agents instead of phospholipids, as seen in liposomes. Niosomes are much more stable during the process of formulation and storage, as compared to liposomes. Niosomes may resolve the issues of insolubility, volatility, poor bioavailability, an

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Shreya, Lokhande* Monika Jadhao. "Transferosomes: A Novel Approach To Drug Delivery." International Journal in Pharmaceutical Sciences 1, no. 9 (2023): 279–87. https://doi.org/10.5281/zenodo.8344306.

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The development of innovative medicine delivery methods is currently generating renewed interest. These innovative drug delivery technologies also include vesicular drug delivery systems. The permeability of the skin, or TDDS, is extremely impermeable to macromolecules and hydrophilic medicines but permeable to small molecules and lipophilic medications. Recent methods have led to the creation of two vesicular carriers: ethosomes and transferosomes, which are incredibly elastic lipid-based vesicles. Recently developed transferosomes are able to deliver both high and low molecular weight medica

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EZEGBE, CHEKWUBE, Ogechukwu Umeh, and Sabinus Ofoefule. "Drug Carriers." Journal of Current Biomedical Research 2, no. 1 (2022): 77–105. http://dx.doi.org/10.54117/jcbr.v2i1.3.

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In recent years, there has been an exponential interest in the development of novel drug delivery systems using drug carriers. Drug carriers offer significant advantages over the conventional drug delivery systems in terms of high stability, high specificity, high drug loading capacity, controlled release of drug and ability to deliver both hydrophilic and hydrophobic drugs. As a result of their unique behaviors, drug carriers have a wide range of biomedical and industrial applications. Nanospheres are associated with a lot of benefits such as ease of administration to target sites, reduction

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Anees, Mukarram, Muhammad Irfan Masood, Mahwish Ilyas, and Muhammad Ammad. "NANOPARTICLES AS A NOVEL DRUG DELIVERY SYSTEM A REVIEW." Pakistan Journal of Pharmaceutical Research 2, no. 2 (2016): 160. http://dx.doi.org/10.22200/pjpr.20162160-167.

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ABSTRACT: Nanotechnology is showing a significant impact on the drug-delivery system over a past few years. This technology is playing a distinct role in remodeling the future of novel drug delivery system (NDDS). Nanoparticles (NPs) are one of the NDDS which exhibit vast applications in the field of clinical medicine and research. The encapsulation of therapeutic drugs in the form of nanoparticles shows advantageous effects, such as increasing drug efficacy, safety, bio-degradability, bioavailability and therapeutic index, over conventional dosage forms of these therapeutic drugs. The current

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N., Madhavi1* CH. Saikiran2 B. Mounika2 B. Swetha2 T. Ramarao3. "A Review On Novel Drug Delivery Systems Used For Delivering Of Drugs Into Ophthalmic Region." International Journal in Pharmaceutical Sciences 2, no. 2 (2024): 392–402. https://doi.org/10.5281/zenodo.10673356.

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Eye is a very sensitive organ, the dosage forms to be administered are very peculiar. Design of ophthalmic drug delivery systems is a major challenge, as they are to be made to pass various ocular barriers and improve drug bioavailability for a prolong period of time. Conventional delivery systems are employed for administration of drug into the ocular region and find difficult to pass through the barriers of the eye, low bioavailability and potential drug side effects, hence the novel drug delivery systems are developed for effective release of drug and prolong release and more retention time

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Amreen, Soha, S. M. Shahidulla, Aasia Sultana, and Nimrah Fatima. "Implantable Drug Delivery System: An Innovative Approach." Journal of Drug Delivery and Therapeutics 13, no. 5 (2023): 98–105. http://dx.doi.org/10.22270/jddt.v13i5.6069.

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The conventional routes of drug administration has limited control over drug release and maintaining constant plasma therapeutic drug concentrations for longer periods of time. To avoid these problems associated with utilization of traditional dosage forms, there was essential need for development of new dosage forms which would discharge drugs at controlled rate for local activity. This led to improvement of Novel Drug Delivery Systems (NDDS) that offers optimisation of therapeutic properties of drugs and makes them safer, productive and dependable over traditional ways of administration. Imp

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Roshani, Garkal* Rugvedi Hiwase Vaishnavi Bhatkar Pooja Bekate Dr. Swati Deshmukh. "Formulation And Evaluation of a Mimosa Pudica Leaf Extract-Based Transdermal Patch Foranti-Inflammatory Activity." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2703–13. https://doi.org/10.5281/zenodo.15438808.

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The present study focuses on the formulation and evaluation of a transdermal drug delivery system (TDDS) incorporating Mimosa pudica extract, a plant known for its potent anti-inflammatory properties. Transdermal patches offer numerous advantages over conventional drug delivery, including sustained release, improved patient compliance, and avoidance of first-pass metabolism. In this work, Mimosa pudica leaves were extracted using methanol, followed by preliminary phytochemical screening to identify bioactive constituents. Transdermal patches were prepared using the solvent casting technique, w

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Muthangi, Sanjana, Praneetha Pallerla, and Srinivas Nimmagadda. "TRANSDERMAL DELIVERY OF DRUGS USING TRANSFEROSOMES: A COMPREHENSIVE REVIEW." Journal of Advanced Scientific Research 14, no. 06 (2023): 30–35. http://dx.doi.org/10.55218/jasr.202314604.

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Transdermal delivery systems have gained popularity as a non-invasive method of drug administration that offers severaladvantages over other routes of drug delivery. They are noninvasive and self-administered delivery system whichimproves patient compliance and provide a controlled release of the drug. The greatest challenge of transdermal deliverysystems is that in which the outermost layer of skin acts as a barrier function for transfer of therapeutic agent into thebody. Molecules with high molecular weights do not pass through the skin. Therefore, only a limited number of drugsare administe

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Majumder, Nairrita, Nandita G Das, and Sudip K. Das. "Polymeric micelles for anticancer drug delivery." Therapeutic Delivery 11, no. 10 (2020): 613–35. http://dx.doi.org/10.4155/tde-2020-0008.

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Polymeric micelles have gained interest as novel drug delivery systems for the treatment and diagnosis of cancer, as they offer several advantages over conventional drug therapies. This includes drug targeting to tumor tissue, in vivo biocompatibility and biodegradability, prolonged circulation time, enhanced accumulation, retention of the drug loaded micelle in the tumor and decreased side effects. This article provides an overview on the current state of micellar formulations as nanocarriers for anticancer drugs and their effectiveness in cancer therapeutics, including their clinical status.

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Mohsen, Amira Mohamed. "Nanotechnology Advanced Strategies for the Management of Diabetes Mellitus." Current Drug Targets 20, no. 10 (2019): 995–1007. http://dx.doi.org/10.2174/1389450120666190307101642.

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Background:Medications currently available for the management of diabetes mellitus are inconvenient and have some limitations. Thus, investigations for novel approaches are needed to deliver and target antidiabetics safely to the site of action.Objective:The present review emphasizes the limitations of conventional antidiabetics and provides the recent progresses of nanotechnology in the treatment of diabetes mellitus with a special highlight on the novel nanocarriers methodologies employed as antidiabetic drug delivery systems.Methods:The potential nanocarriers employed for the treatment of d

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Ashara, Kalpesh C., Jalpa S. Paun, M. M. Soniwala, J. R. Chavada, and J. K. Badjatiya. "NANOPARTICULATE DRUG DELIVERY SYSTEM: A NOVEL APPROACH." International Journal of Drug Regulatory Affairs 1, no. 2 (2018): 39–48. http://dx.doi.org/10.22270/ijdra.v1i2.109.

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As because of several advantages over to the conventional drug delivery Nanosparticulate drug delivery prepared in several means by several ways of methods have several applications in different discipline of Pharmaceutical science. There are various parameters for Evaluation of Nanoparticles as Drug Delivery system so we can justified as nanoparticulate drug delivery system: a novel approach.

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Sharma, Aditya, Lakhvinder Kumar, Prevesh Kumar, Neelkant Prasad, and Vaibhav Rastogi. "Niosomes: A Promising Approach in Drug Delivery Systems." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 635–42. http://dx.doi.org/10.22270/jddt.v9i4.3064.

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Design of vesicles as a tool to enhance drug delivery has created a lot of interest among humans operating within drug delivery systems space over the past decade. Niosomes are formations of vesicles by a hydrating mixture of cholesterol and nonionic surfactants. Completely different novel approaches used to deliver these medicines include liposomes, microspheres, engineering science, small emulsions, antibody-loaded drug delivery, magnetic microcapsules, implantable pumps and niosomes. Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should distribu

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Patel, Manish Kumar, and Nandu Rangnath Kayande. "Analytical Optimization of Multiunit Particulate System (MUPS) Tablet – A Novel Drug Delivery System." International Journal of Research 11, no. 7 (2024): 337–45. https://doi.org/10.5281/zenodo.13336435.

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<em>Multiunit particulate delivery element of the drug is new emerging sake for the modified release and / or craving release solid dosage forms. In general, MUPS are consisted of thousands of tiny particles or pellets or micro-granules exhibiting same characteristics, which are formulated either in a form of tablet or directly filled in the capsule. In few cases it is delivered in the sachet as pellets as such. Active drug substance is present in these tiny particles. These delivery systems perceived advantageous over conventional solid dosage form drug delivery systems such as more uniform b

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Nikolova, Maria P., Enamala Manoj Kumar, and Murthy S. Chavali. "Updates on Responsive Drug Delivery Based on Liposome Vehicles for Cancer Treatment." Pharmaceutics 14, no. 10 (2022): 2195. http://dx.doi.org/10.3390/pharmaceutics14102195.

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Liposomes are well-known nanoparticles with a non-toxic nature and the ability to incorporate both hydrophilic and hydrophobic drugs simultaneously. As modern drug delivery formulations are produced by emerging technologies, numerous advantages of liposomal drug delivery systems over conventional liposomes or free drug treatment of cancer have been reported. Recently, liposome nanocarriers have exhibited high drug loading capacity, drug protection, improved bioavailability, enhanced intercellular delivery, and better therapeutic effect because of resounding success in targeting delivery. The s

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Alfuraiji, Narjes, Weam Kadhim, Rana Hameed, and Qasim Chyad Abdulzahra. "Application of Nano-particulate drug delivery systems to deliver therapeutic agents into cancer cells." Karbala Journal of Medicine 14, no. 2 (2022): 2496–512. http://dx.doi.org/10.70863/karbalajm.v14i2.886.

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Cancer is a disorder in which a group of cells grows uncontrollably, disregarding the cell division's physiological rules. Since its discovery (although the word cancer was not used)3000 BC, extraordinary research aims to uncover novel treatment approaches for combating cancer. Currently, over 60% of all ongoing clinical trials worldwide focus on cancer. The selection of treatment depends on the type of cancer, site, and stage of progression. Surgery, radiation-based surgical knives, chemotherapy, and radiotherapy are traditional treatment approaches that are mostly used. Side effects associat

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K., Mounika, Praneetha P., and Srinivas N. "TRANSFERSOMES AS NOVEL DRUG DELIVERY SYSTEM." International Journal of Advanced Research 11, no. 04 (2023): 877–81. http://dx.doi.org/10.21474/ijar01/16737.

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Transdermal drug delivery appears to be most vital drug delivery system because of its merit over conventional systems. Transferosomes & the fundamental concept of transfersomes were launched by Gregor Cevc in the year 1991. The name means carrying body and is derived from the Latin word transferre, meaning to carry across and the Greek word soma, meaning a body. Novel drug delivery system aims to deliver the drug at a rate directed by need of body during the period of treatment and channel the active entity to the site of action. Transferosome is one of the novel vesicular drug delivery s

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Prajakta N. Dongare, Anuja S. Motule, Mahesh R. Dubey, et al. "Recent development in novel drug delivery systems for delivery of herbal drugs: An updates." GSC Advanced Research and Reviews 8, no. 2 (2021): 008–18. http://dx.doi.org/10.30574/gscarr.2021.8.2.0158.

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In the recent years, herbal medicines have gained worldwide attention of peoples and researchers due to their esthetic value, more patient’s compliance and prominent therapeutic effects. Novel drug delivery systems for delivery of herbal drugs possesses several advantages over conventional formulations. It includes enhancement of solubility, bioavailability, and protection from toxicity, etc. The herbal drugs can be used in a more upright course with enhanced efficacy by incorporating them into suitable dosage forms. This can be achieved by designing novel drug delivery systems for such drugs.

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Prajakta, N. Dongare, S. Motule Anuja, R. Dubey Mahesh, et al. "Recent development in novel drug delivery systems for delivery of herbal drugs: An updates." GSC Advanced Research and Reviews 8, no. 2 (2021): 008–18. https://doi.org/10.5281/zenodo.5195564.

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In the recent years, herbal medicines have gained worldwide attention of peoples and researchers due to their esthetic value, more patient’s compliance and prominent therapeutic effects. Novel drug delivery systems for delivery of herbal drugs possesses several advantages over conventional formulations. It includes enhancement of solubility, bioavailability, and protection from toxicity, etc. The herbal drugs can be used in a more upright course with enhanced efficacy by incorporating them into suitable dosage forms. This can be achieved by designing novel drug delivery systems for such

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Vaishnavi S. Mukhmale, Sakshi Y. Patrikar, Nandkishor B. Deshmukh, and Swati P. Deshmukh. "Implantable drug delivery systems: An overviews." GSC Advanced Research and Reviews 22, no. 1 (2025): 123–32. https://doi.org/10.30574/gscarr.2025.22.1.0002.

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Implant are sterile solid mass that contains medicine, prepared by different ways like extrusion, moulding or contraction. The conventional routes of medicine administration has limited control over medicine release and maintaining constant tube remedial medicine attention for longer ages of time. To avoid these problems associated with application of traditional lozenge forms, there was essential need for development of new lozenge forms which would discharge medicines at controlled rate for original exertion. This led to enhancement of Novel Drug Delivery Systems (NDDS) that offers optimisat

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Uma, M* Nagaraja T.S Vitthal K. Vijapure Bharathi D.R. "DEVELOPMENT AND EVALUATION OF NIOSOMAL DRUG DELIVERY SYSTEM CONTAINING TRANEXAMIC ACID." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 06 (2019): 13113–23. https://doi.org/10.5281/zenodo.3257978.

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<em>The present study aimed to optimize the drug delivery of tranexamic acid from the niosomes by using different grades of surfactants and cholesterol at different molar concentrations in order to achieve prolonged release time and sustained release. Tranexamic acid is one of the most effective anti</em><em>fibrinolytic drugs used in the treatment of fibrinolysis.</em><em> Niosomes are the novel vesicular drug delivery system by which we can achieve the constant plasma drug concentration for the extended period of time. The vesicles are prepared from nonionic surfactants and cholesterol by th

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Yu, Huang-Ping, Ibrahim A. Aljuffali, and Jia-You Fang. "Injectable Drug-Loaded Nanocarriers for Lung Cancer Treatments." Current Pharmaceutical Design 23, no. 3 (2017): 481–94. http://dx.doi.org/10.2174/1381612822666161027113654.

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Different types of injectable nanoparticles, including metallic nanoparticles, polymeric nanocarriers, dendrimers, liposomes, niosomes, and lipid nanoparticles, have been employed to load drugs for lung delivery. Nanoparticles used for lung delivery offer some benefits over conventional formulations, including increased solubility, enhanced stability, improved epithelium permeability and bioavailability, prolonged half-life, tumor targeting, and minimal side effects. In recent years, the concept of using injectable nanocarriers as vehicles for drug delivery has attracted increasing attention.

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Joshi, Shailendra, Jason Ellis, and Charles Emala. "Revisiting intra-arterial drug delivery for treating brain diseases or is it “déjà-vu, all over again”?" Journal of Neuroanaesthesiology and Critical Care 01, no. 02 (2014): 108–15. http://dx.doi.org/10.4103/2348-0548.130386.

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AbstractFor over six decades intra-arterial (IA) drugs have been sporadically used for the treatment of lethal brain diseases. In recent years considerable advance has been made in the IA treatment of retinoblastomas, liver and locally invasive breast cancers, but relatively little progress has been made in the treatment of brain cancers. High resting blood flow and the presence of the blood-brain barrier (BBB), makes IA delivery to the brain tissue far more challenging, compared to other organs. The lack of advance in the field is also partly due to the inability to understand the complex pha

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Sheth, Maitry, Divya Jadhav, Hitesh Jain, and D. B. Meshram. "Pre-Liposomes: A novel drug delivery system." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 525–28. http://dx.doi.org/10.22270/jddt.v9i2-s.2613.

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Preliposomes are a novel drug delivery system (NDDS). Preliposomes, due to their various forms, require further exploration. These structures can deliver both hydrophilic and hydrophobic drugs for cancer, bacterial infections, fungal infections, immunomodulation, diagnostics, ophthalmic, vaccines, enzymes and genetic elements. Prevesicular drug delivery system like preliposomes having distinct advantages over conventional drug delivery system. These systems overcome the problems associated with instability of liposomes. preliposomes composed of water-soluble porous powder as carrier which havi

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Srinu, K., and S. Sravani. "A Review on Gastroretentive Drug Delivery System." International Journal for Research in Applied Science and Engineering Technology 12, no. 11 (2024): 2084–88. http://dx.doi.org/10.22214/ijraset.2024.65547.

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Abstract: Day by day the topic GRDDS has becoming popular due to its good therapeutic values and ease of cost of manufacturing. Gastro retentive drug delivery system is a type of retentive system it means which holds the drugs for prolonged time in GI fluid and release the drug in a controlled manner. And this article explores significance of GRDDS and its advantages over conventional system. This also focuses on the anatomy of stomach, introduction to GRDDS, criteria for selection of drug candidate for GRDDS, technologies of GRDDS. Keywords: Gastro-retentive, Controlled release , Site-specifi

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K, Dudhat. "An Insight to Modified Release Dosage Form with Osmotic Drug Delivery System." Bioequivalence & Bioavailability International Journal 7, no. 1 (2023): 1–4. http://dx.doi.org/10.23880/beba-16000193.

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Osmotic drug delivery is a technique for managing the controlled, prolonged release of medications. A semi-permeable membrane is used to separate two compartments, one of which contains the medicine and the other of which contains an osmotic agent, in the system, which is based on the osmosis principle. The medicine is pushed through the membrane at a controlled rate thanks to the pressure differential created when the osmotic agent sucks water from the body into the drug compartment. The system can be set up to disperse medications over long periods of time, from a few hours to several months

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Samatha, Garrepalli. "Fenofibrate Niosomes by Modified Ether Injection Method- of Proper Diet to Help Lower “Bad." Gastroenterology Pancreatology and Hepatobilary Disorders 2, no. 1 (2018): 01–03. http://dx.doi.org/10.31579/2641-5194/005.

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The quest never ends. From the very beginning of the human race the quest is going on for newer and better alternatives and in case of drugs it will continue till we find a drug with maximum efficacy and no side effects. Many drugs, particularly chemotherapeutic agents, have narrow therapeutic window and their clinical uses are limited and compromised by dose limiting toxic effect. Thus, the therapeutic effectiveness of the existing drugs is improved by formulating them in an advantageous way. In the past few decades, considerable attention has been focused on the development of new drug deliv

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