Academic literature on the topic 'Overactive Urinary Bladder'
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Journal articles on the topic "Overactive Urinary Bladder"
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ABREU, Glícia Estevam de, Eneida Regis DOURADO, Danielle de Novais ALVES, Milly Queiroz de ARAUJO, Natália Souza Paes MENDONÇA, and Ubirajara BARROSO JUNIOR. "FUNCTIONAL CONSTIPATION AND OVERACTIVE BLADDER IN WOMEN: A POPULATION-BASED STUDY." Arquivos de Gastroenterologia 55, suppl 1 (August 21, 2018): 35–40. http://dx.doi.org/10.1590/s0004-2803.201800000-46.
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ABSTRACT BACKGROUND: An association between urinary disorders and functional constipation has been registered in children and adults, with functional constipation being a common complaint in individuals with overactive bladder. OBJECTIVE: To evaluate the prevalence of functional constipation, overactive bladder and its dry/wet subtypes in women and to determine which bowel symptoms predict overactive bladder. METHODS: A cross-sectional study of women randomly approached in public spaces. Exclusion criteria: neurological/anatomical abnormalities of the bowel or urinary tract. Constipation was defined as ≥2 positive symptoms of those listed in the Rome criteria. Urinary abnormalities (frequent urination, urgency, incontinence, nocturia) were defined by a score ≥2 in the respective item of the International Consultation on Incontinence Questionnaire - Overactive Bladder. Dry overactive bladder was defined as urgency without incontinence, while wet overactive bladder included incontinence. RESULTS: A total of 516 women with a mean age of 35.8±6 years were interviewed. Rates of functional constipation, overactive bladder, dry overactive bladder and wet overactive bladder were 34.1%, 15.3%, 8.9% and 6.4%, respectively. Functional constipation was associated with overactive bladder and dry overactive bladder, with functional constipation predicting dry overactive bladder (OR=2.47). Quality of life was poorer in constipated women compared to non-constipated and even worse in constipated women with wet overactive bladder (median 22.5; 95%CI: 17.25-35.25). Manual maneuvers were significantly associated with both overactive bladder subtypes. Independent predictive factors for overactive bladder were manual maneuvers (OR=2.21) and <3 defecations/week (OR=2.18), with the latter being the only predictive factor for dry overactive bladder (OR=3.0). CONCLUSION: Functional constipation is associated with overactive bladder and its dry subtype, particularly in the younger population. In addition, this association is responsible for lower quality of life scores, especially when urinary incontinence is present. The presence of manual maneuvers and less than three defecations per week should direct us to look for overactive bladder.
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Zwierzyńska, Anna. "Overactive bladder." Journal of Education, Health and Sport 11, no. 7 (July 15, 2021): 116–23. http://dx.doi.org/10.12775/jehs.2021.11.07.010.
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Urinary incontinence is a problem among both older and young women. The most common symptoms of this condition include urinary incontinence and an unpleasant odour. In order to conceal the ailments related to this problem, women change their lifestyle by limiting the amount of fluid consumed and not moving too far from home or places where toilets are located. The main source of information on this disease in women aged over 45 is books, magazines and websites. Medical personnel are only ranked behind them. In order to make a correct diagnosis of this disease and to start treatment, urodynamic examination, urinalysis, cystoscopy and imaging examinations should be performed. Urodynamic examination can be divided into two groups: invasive and non-invasive. The micturition diary is considered to be the basic urodynamic test. It allows for performing differential diagnosis of functional micturition disorders. It is characterized by high repeatability and correlation with clinical symptoms. Treatment options are dependent on the type of urinary incontinence. They may include conservative treatment, surgery and pharmacotherapy. Combining conservative methods with pharmacological or surgical methods brings the most beneficial results. Invasive methods are the last-line therapy.
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Hwang, Ye-Chae, Hye-Jin Lee, Hye-Min Heo, Gyu-Ri Jeon, Seung-Yeon Cho, Seong-Uk Park, Chang-Nam Ko, and Jung-Mi Park. "Clinical Report of Baliao Electroacupuncture Treatment on a Stroke Patient Suffering from a Neurogenic Overactive Bladder." Journal of Internal Korean Medicine 43, no. 1 (March 31, 2022): 90–103. http://dx.doi.org/10.22246/jikm.2022.43.1.90.
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Objective: The purpose of this case study is to report the effectiveness of Baliao acupoints electro-acupuncture treatment on a neurogenic overactive bladder induced by stroke.Method: A patient suffering from middle cerebral artery infarction was diagnosed with a neurogenic overactive bladder and treated by Korean medicine, including electro-acupuncture on Baliao acupoints six times per week. The evaluation was performed by monitoring urinary frequency and using the Korean versions of the Overactive Bladder Symptom Score (OABSS) and Urinary Incontinence Quality of Life (I-QoL).Results: After 27 days of electro-acupuncture treatment, the OABSS score improved from 6 to 3. The I-QoL total score improved from 60 to 87. The patient also showed a decrease in nocturia frequency.Conclusion: This case suggests that electro-acupuncture on Baliao acupoints can be effective for overactive bladders due to supra-pontine lesions.
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Utama, Bobby Indra, Widayat Widayat, and Berriandi Arwan. "The Incidence of Overactive Bladder (OAB) in KIA Poly Patients at Pauh Health Center in Padang City Using Overactive Bladder Symptoms Score (OABSS)." JOURNAL OBGIN EMAS 3, no. 2 (November 27, 2019): 55–62. http://dx.doi.org/10.25077/aogj.3.2.55-62.2019.
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Objective : This study looked at the incidence of overactive bladder (OAB) in KIA poly patients at Pauh Health Center in Padang City using Overactive Bladder Symptomps Score (OABSS).Method : This research is descriptive. The sampling technique was purposive sampling by considering inclusion and exclusion criteria. The inclusion criteria were women of ideal reproductive age (20-35 years) who had given birth spontaneously, were not pregnant, did not suffer from neurological disorders, diabetes, post bladder surgery and or urinary tract infections and were not treated with Overactive Bladder (OAB), while the exclusion criteria are not willing to take part in the study. The study was carried out at the KIA Poly of Pauh City Health Center in Padang during January 2019. The variable in this study was Overactive Bladder (OAB).Result : In this study, 97.22% of respondents experienced complaints of overactive bladder (OAB), (97.14%) experienced an urgent complaint, and only a small percentage (2.86%) of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1).Conclusion : Most respondents experienced complaints of overactive bladder (OAB) and urgency, and only a small proportion of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1).Keywords : overactive bladder (OAB), Urgensi,inkontinensia urin, Overactive Bladder Symptom Scores (OABSS).
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Utama, Bobby Indra, Widayat Widayat, and Berriandi Arwan. "The Incidence of Overactive Bladder in KIA Poly Patients at Pauh Health Center in Padang City Using Overactive Bladder Symptoms Score." JOURNAL OBGIN EMAS 3, no. 2 (December 12, 2019): 83–89. http://dx.doi.org/10.25077/aoj.3.2.83-89.2019.
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Objective : This study looked at the incidence of overactive bladder (OAB) in KIA poly patients at Pauh Health Center in Padang City using Overactive Bladder Symptomps Score (OABSS).Method : This research is descriptive. The sampling technique was purposive sampling by considering inclusion and exclusion criteria. The inclusion criteria were women of ideal reproductive age (20-35 years) who had given birth spontaneously, were not pregnant, did not suffer from neurological disorders, diabetes, post bladder surgery and or urinary tract infections and were not treated with Overactive Bladder (OAB), while the exclusion criteria are not willing to take part in the study. The study was carried out at the KIA Poly of Pauh City Health Center in Padang during January 2019. The variable in this study was Overactive Bladder (OAB).Result : In this study, 97.22% of respondents experienced complaints of overactive bladder (OAB), (97.14%) experienced an urgent complaint, and only a small percentage (2.86%) of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1). Conclusion : Most respondents experienced complaints of overactive bladder (OAB) and urgency, and only a small proportion of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1).Keywords: overactive bladder (OAB), Urgensi,inkontinensia urin, Overactive Bladder Symptom Scores (OABSS)
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Kostiuk, I., G. Chayka, and Yu Garnets. "The urethral closure function status in pregnant women suffering from overactive bladder syndrome." HEALTH OF WOMAN, no. 9(135) (November 30, 2018): 66–69. http://dx.doi.org/10.15574/hw.2018.135.66.
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The ultrasound method of investigation was proposed as the first step in the diagnosis of urinary incontinence, since the average value of the thickness of the bladder wall and the size of the urethral sphincter in the works of many urologists are correlated with the presence of overactive bladder. The objective: was to determine the sonographic parameters of the urethral closure in pregnant women with overactive urinary bladder. Materials and methods. In this article, an estimation of such ultrasound signs of the urethral closure apparatus, such as funnel-like urethral enlargement, bladder wall thickness measurement, bladder volume, residual urine volume, were performed. The diagnostic value of the cervical-bulk test in pregnant women with overactive urinary bladder is assessed. The obtained results were compared with the same in healthy pregnant women. Results. The index of bladder wall thickness with age increases, as in women with overactive bladder, and in practically healthy women. However, significantly higher value of this indicator (p<0,001) was found in the group of women with overactive bladder. In the third trimester of pregnancy, a positive cervical-bleb test was found in all patients with overactive bladder. In the group of pregnant women with overactive bladder, significantly less volume of the bladder and increased volume of residual urine, which confirms the world data. Conclusion. Data of spontaneous contractions of detrusor in pregnant women suggest that this indicator is a characteristic diagnostic feature of overactive bladder. Key words: pregnancy, ultrasound examination, urethral closure, overactive bladder.
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Rogowski, Artur, Maria Krowicka-Wasyl, Ewa Chotkowska, Tomasz Kluz, Andrzej Wróbel, Dominika Berent, Paweł Mierzejewski, et al. "Psychiatric History and Overactive Bladder Symptom Severity in Ambulatory Urogynecological Patients." Journal of Clinical Medicine 10, no. 17 (September 3, 2021): 3988. http://dx.doi.org/10.3390/jcm10173988.
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Introduction and hypothesis: A link between psychiatric comorbidities and overactive bladder symptomatology has been suggested by preclinical and clinical studies. Given this, we hypothesized that a psychiatric history and current treatment with psychotropic medications could be related to the severity of overactive bladder and incontinence symptoms in patients referred to a tertiary care urogynecological center. Methods: One hundred and twenty-seven female patients diagnosed with an overactive bladder were screened for a lifetime history of psychiatric disorders and the type and number of psychotropic medications currently taken. The overall severity of overactive bladder symptoms was assessed using the Indevus Urgency Severity Scale. The severity and impact of urinary incontinence on the quality of life were quantified with the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form. Urinary incontinence was further quantified with the aid of the Urinary Distress Inventory-6. The patients were screened for stress urinary incontinence using the Stamey Incontinence Score. Results: A psychiatric history, as well as current use of at least two psychotropic medications, was associated with increased severity of overactive bladder symptoms. A history of depression and current treatment with any selective serotonin reuptake inhibitor was associated with increased severity of stress urinary incontinence symptoms. Current treatment with other psychotropic medications, including sedative-hypnotics and drugs with anticholinergic properties was not related to the severity of overactive bladder and incontinence symptoms.
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Trivedi, Sameer, Pranab Patnaik, Yashpal Ramole, Faiz Ahmed Khan, Ragini Srivastava, and Udai Shankar Dwivedi. "Role of Serum and Urinary Biomarkers in Evaluation and Management of Patients With Overactive Bladder." Clinical Medicine Insights: Urology 12 (January 2019): 117956111986490. http://dx.doi.org/10.1177/1179561119864907.
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Background: This study compared urinary and serum nerve growth factor levels and serum C-reactive protein levels in patients with overactive bladder, before and after treatment with antimuscarinic agents, to evaluate their diagnostic and therapeutic importance. Methods: This was a prospective case-control study conducted between February 2014 and December 2014 which included patients with a confirmed diagnosis of overactive bladder (overactive bladder group) and healthy controls (control group). All patients visiting urology out-patient department with urgency, frequency, and urge incontinence were assessed for overactive bladder and, if eligible, were enrolled in the study. Biomarkers were evaluated before in both groups and after antimuscarinic treatment in the overactive bladder group. Results: Overall, 80 participates were enrolled (overactive bladder, n = 40; control, n = 40). The mean age was not different between the two groups (overactive bladder, 48.6 years; control, 46.9 years [ P = 1.01]) and females were more in both the groups (60% and 55%, respectively). The majority (70%) of patients presented with frequency and urgency. After 3 months of treatment with antimuscarinics, the mean overactive bladder symptom score decreased significantly from 8.4 to 4.85 ( P < .001). The mean urinary and serum nerve growth factor levels and serum C-reactive protein levels also decreased significantly from baseline after 3 months of treatment with antimuscarinics (24.78 pg/mL, 22.46 pg/mL, 0.89 mg/L, respectively; P < .0001). Conclusions: Measurement of urinary and serum nerve growth factor levels has diagnostic and therapeutic potential in patients with overactive bladder.
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Kuzmin, Igor V., Margarita N. Slesarevskaya, and Viktoria V. Romikh. "Overactive bladder, inflammation and urinary tract infection: pathogenetic parallels." Urology reports (St. - Petersburg) 14, no. 1 (March 29, 2024): 65–79. http://dx.doi.org/10.17816/uroved627461.
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The review is devoted to modern ideas about the role of inflammation and urinary tract infection in the pathogenesis of overactive bladder. The molecular mechanisms of the mechanosensory function of the urothelium and the influence of bacterial colonization of the urothelium on it are described in detail. It has been shown that infectious inflammation, even in the absence of clinical symptoms, enhances the urothelial response to stretching and increases the excitability of afferent nerves. Bladder hypersensitivity and increased detrusor activity are pathogenetic basis for the development of overactive bladder. Data on the relationship between urinary infection and refractory overactive bladder are presented. The feasibility of conducting extended microbiological studies in patients with overactive bladder , especially when standard therapy is ineffective, has been demonstrated. A pathogenetic rationale for prescribing anti-inflammatory and immunoactive drugs to patients with overactive bladder is presented.
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Subhan, Sana, Syed Imran Ahmad, Muhammad Hammad Ali Mithani, Aftab Ahmed Mirza Baig, Muhammad Kashif, and Muhammad Arif Siddiqui. "Effects of transcutaneous tibial nerve stimulation for overactive bladder symptoms in adults: A randomized controlled trial." Rehabilitation Journal 07, no. 03 (September 30, 2023): 36–41. http://dx.doi.org/10.52567/trehabj.v7i03.7.
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Background: Overactive bladder (OAB) is characterized by urinary urgency, frequency, and nocturia, often accompanied by urinary incontinence. OAB significantly impacts the quality of life of affected individuals. Transcutaneous Tibial Nerve Stimulation (TTNS) is a non-invasive treatment option used to manage overactive bladder (OAB) symptoms. Objective: to determine the effects of Transcutaneous Tibial Nerve Stimulation on overactive bladder symptoms in adults. Methods: A randomized controlled trial was held at the Sindh Institute of Physical Medicine and Rehabilitation with a non-probability purposive sampling technique. After screening for inclusion criteria 60 patients were randomly allocated into two Group A received Transcutaneous tibial nerve stimulation (TTNS) combined with traditional physiotherapy, while Group B just received traditional physiotherapy. Both interventions were given for six weeks. The overactive Bladder Symptom Score was used as an outcome measure tool. Results: Group A improved in all OAB parameters, including daytime frequency (p=0.008), nocturia (p=0.006), urinary urgency (p=0.002), and urge urinary incontinence (p=0.008) with a significant improvement p<0.05. All OABSS parameters in group B also showed a considerable improvement (p<0.05), except for urge urinary incontinence (p=0.08). Conclusion: the daytime frequency, nocturia, and urgency parameters of the overactive bladder symptoms score significantly decreased in both the TTNS+PFM group and the Traditional physiotherapy group. However, urge urinary incontinence showed significant improvement only in the TTNS+PFM group.
Dissertations / Theses on the topic "Overactive Urinary Bladder"
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Moonat, Shweta. "Investigation of neural correlates of bladder control using functional magnetic resonance imaging (fMRI) in patients with overactive bladder (OAB)." Master's thesis, Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/217452.
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Electrical Engineering;M.S.E.E.;
Overactive bladder (OAB) is considered to be a disorder of the urinary bladder and is defined by the International Continence Society Terminology Committee as "urgency, with or without urge incontinence, usually with frequency and nocturia". There is some preliminary evidence using functional magnetic resonance imaging (fMRI) that the brain response to bladder filling in OAB patients is abnormal. The purpose of this research is to determine whether there are Central Nervous System (CNS) differences in modulating bladder function that contribute to, or are themselves the cause of the symptoms in OAB patients. We further investigated the pharmacological fMRI changes
Temple University--Theses
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Omae, Kenji. "Gait speed and overactive bladder in the healthy community-dwelling super elderly-The Sukagawa Study." Kyoto University, 2020. http://hdl.handle.net/2433/245838.
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Correia, Sofia Gonçalves. "Urinary incontinence and overactive bladder in the non-institutionalized Portuguese population: national survey and methodological issues." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2008. http://hdl.handle.net/10216/21944.
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Correia, Sofia Gonçalves. "Urinary incontinence and overactive bladder in the non-institutionalized Portuguese population: national survey and methodological issues." Dissertação, Faculdade de Medicina da Universidade do Porto, 2008. http://hdl.handle.net/10216/21944.
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Schoendorfer, Niikee, Nita Sharp, Tracey Seipel, Alexander G. Schauss, and Kiran D. K. Ahuja. "Urox containing concentrated extracts of Crataeva nurvala stem bark, Equisetum arvense stem and Lindera aggregata root, in the treatment of symptoms of overactive bladder and urinary incontinence: a phase 2, randomised, double-blind placebo controlled trial." BIOMED CENTRAL LTD, 2018. http://hdl.handle.net/10150/627047.
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Background: Storage lower urinary tract symptoms (LUTS) including overactive bladder (OAB) and urinary incontinence (UI) affect millions of people worldwide, significantly impacting quality of life. Plant based medicines have been documented both empirically and in emerging scientific research to have varying benefits in reducing bladder symptoms. We assessed the efficacy of Urox (R), a proprietary combination of phytomedicine extracts including, Cratevox (TM) (Crataeva nurvala) stem bark, Equisetem arvense stem and Lindera aggregata root, in reducing symptoms of OAB and UI. Methods: Efficacy of the herbal combination on a variety of bladder symptoms compared to an identical placebo, were documented in a randomised, double-blind, placebo controlled trial conducted at two primary care centres. Data were collected at baseline, 2, 4 and 8 weeks, with the primary outcome being self-reported urinary frequency. Statistical analysis included mixed effects ordered logistic regression with post hoc Holm's test to account for repeated measures, and included an intention-to-treat analysis. Results: One hundred and fifty participants (59% female, aged; mean +/- SD; 63.5 +/- 13.1 years) took part in the study. At week 8, urinary day frequency was significantly lower (OR 0.01; 95%CI 0.01 to 0.02; p < 0.001) in response to treatment (mean +/- SD; 7.69 +/- 2.15/day) compared to placebo (10.95 +/- 2.47/day). Similarly, episodes of nocturia were significantly fewer (OR 0.03; 95%CI 0.02 to 0.05) after 8 weeks of treatment (2.16 +/- 1.49/night) versus placebo (3.14 +/- 1.36/night). Symptoms of urgency (OR 0.02; 95%CI 0.01 to 0.03), and total incontinence (OR 0.03; 95%CI 0.01 to 0.06) were also lower (all p < 0.01) in the treatment group. Significant improvements in quality of life were reported after treatment in comparison to placebo. No significant side effects were observed resulting in withdrawal from treatment. Conclusions: The outcome of this study demonstrated both statistical significance and clinical relevance in reducing symptoms of OAB, urinary frequency and/or urgency and incontinence. The demonstrated viability of the herbal combination to serve as an effective treatment, with minimal side-effects, warrants further longer term research and consideration by clinicians.
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Leiria, Luiz Osório 1983. "Estudo morfofuncional e molecular do baixo trato urinário de camudongos diabéticos." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308913.
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Orientador: Edson AntunesDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-17T02:28:29Z (GMT). No. of bitstreams: 1 Leiria_LuizOsorio_M.pdf: 1930744 bytes, checksum: 214d355861ca93277cceba03b993e869 (MD5) Previous issue date: 2010
Resumo: As disfunções do baixo trato urinário estão entre as complicações mais comumente associadas ao diabetes mellitus, e incluem urgência miccional, alterações da freqüência e incontinência urinária, hiperatividade e hipertrofia da bexiga, tornando complexos os procedimentos diagnósticos e terapêuticos. O mediador primário para a contração do músculo liso detrusor é a acetilcolina (Ach), sendo suas ações mediadas, principalmente, pelos receptores muscarínicos do subtipo M3 e M2, principalmente o subtipo M3. O receptor P2X1, ativado pelo trifosfato de adenosina (ATP), também participa da contração do detrusor; porém, com menor importância. Ambos promovem a contração através da mobilização de Ca2+ citosólico, seja pela formação de inositol trifosfato (IP3), seja pelo influxo de Ca2+ extracelular via canais de Ca2+ tipo L. Além destes mecanismos, os receptores M3 podem desencadear resposta contrátil independente da concentração de Ca2+ citosólico, através da sensibilização ao mesmo, a qual ocorre, principalmente, pela ação da enzima Rho-kinase. A despeito de sua grande relevância na contração da bexiga, até o presente, poucos estudos abordaram as alterações na homeostase do Ca2+ celular resultantes do diabetes mellitus. Além disso, a contribuição da uretra para a cistopatia diabética ainda é pouco compreendida e estudada. O objetivo deste trabalho foi investigar as alterações funcionais, morfológicas e moleculares do baixo trato urinário em camundongos C57BL/6 com diabetes induzida por estreptozotocina, bem como compreender o papel da uretra na fisiopatologia desta desordem. Para tanto, realizamos os seguintes experimentos: 1) análise histomorfométrica da bexiga; 2) estudo cistométrico; 3) concentração-resposta ao agonista muscarínico carbacol (na ausência e na presença do Y27632 ou nifedipina), ao agonista purinérgico ?,?-metileno ATP, cloreto de potássio (KCl) e ao cloreto de cálcio (CaCl2), assim como curvas freqüência-resposta à estimulação elétrica (1-32 Hz, 80 V, 10 segundos) em detrusor isolado, e montado em banho para órgão preenchido com solução de Krebs Henseleit; 4) curvas concentração-resposta ao agonista ?1-adrenérgico fenilefrina, bem como de relaxamento ao nitroprussiato de sódio, tadalafil e Bay 41-2272, em anéis de músculo liso de uretra; 6) expressão de RNAm de receptores muscarínicos M2 e M3, purinérgicos P2X1 e canais de Ca2+ tipo L em detrusor. Os animais diabéticos apresentaram aumento do peso da bexiga, da espessura da parede e do volume da mesma em relação aos camundongos controle. A densidade de tecido neural também foi maior no grupo diabético, enquanto nenhuma alteração foi verificada em relação à densidade de músculo liso e de colágeno. O estudo cistométrico revelou aumento da capacidade e complacência da bexiga nos animais diabéticos, assim como maior amplitude das contrações de micção, aumento da freqüência de micção e de contrações involuntárias. Estes ainda exibiram aumento da pressão intravesical pós-miccional, evidenciando uma perda da eficiência da micção. A contratilidade do detrusor isolado de camundongos diabéticos se mostrou maior em resposta ao carbacol, ?,?-metileno ATP, KCl, CaCl2 e estímulo elétrico. Para avaliar o papel dos canais de Ca2+ tipo L e da rho-quinase no aumento da resposta contrátil ao carbacol, realizamos curvas ao carbacol na presença do bloqueador de canal de Ca2+ tipo L, nifedipina (3 nM) ou do inibidor da rho-quinase, Y27632 (1 µM). A pré-incubação com nifedipina preveniu o aumento da contração no grupo diabético, enquanto na presença do Y27632 não houve redução significativa das contrações em ambos os grupos. A expressão de RNAm de receptores M3 foi significativamente maior no grupo diabético em comparação com o grupo controle, enquanto não foram observadas alterações significativas na expressão de receptores M2 e P2X1. Os camundongos diabéticos exibiram aumento significativo da expressão de RNAm de canais de Ca2+ tipo L. As curvas concentração-resposta em músculo liso de uretra revelaram aumento da contração em resposta à fenilefrina e redução do relaxamento ao doador de óxido nítrico (NO), nitroprussiato de sódio (SNP), no grupo diabético. Em suma, nossos dados mostram que o aumento da contração do músculo detrusor em camundongos diabéticos é devido ao aumento do influxo de Ca2+ extracelular através dos canais de Ca2+ tipo L e ao aumento da expressão de receptores muscarínicos M3. Além disso, o aumento da resistência mecânica da uretra resultou em perda da eficiência do esvaziamento da bexiga associada à hiperatividade da mesma
Abstract: Bladder dysfunction is among the most common and incapacitating complications of diabetes mellitus. The diabetes related lower urinary tract symptoms (LUTS) include overactive bladder, incontinence, urgency, frequency increase and bladder hypertrophy. Acethylcholine (ACh) is the main neurotransmitter responsible for the detrusor smooth muscle contraction, acting mainly at the muscarinic M2 and M3 subtypes. P2X1, through ATP stimuli, also contribute to void contractions. Both M3 and P2X1 activation triggers citosolic Ca2+ mobilization by triphosphate inositol (IP3) formation or extracellular Ca2+ influx through L-type Ca2+ channels. Activation of M3 receptors can also elicit contractile response through Ca2+ concentration-independent pathways. Despite the great importance of Ca2+ handling/homeostases to receptor-mediated bladder contractions, its contribution to diabetic cistopathy has been little studied. In addition, the contribution of urethra in diabetic cistopathy remains poorly comprehended. The present study was designed to evaluate the functional, structural and molecular alterations of detrusor and urethral smooth muscles (DSM) in streptozotocin-induced diabetic mice. The following experiments were performed: 1) Hystomorfometric measurements; 2) Cystometric study; 3) Contractile responses to the muscarinic agonist carbachol (in the absence and in the presence of nifedipine or Y27632), purinergic agonist ?,?-methylene ATP, KCl, CaCl2 and electrical field stimulation (EFS, 1-32 Hz, 80 V, 10 sec) in detrusor strips mounted in organ baths containing Krebs-Henseleit solution; 4) Concentration-response curves to the ?1-adrenergic agonist phenylefrine were performed in isolated rings of urethral smooth muscle and relaxant curves to sodium nitroprusside (SNP), tadalafil and Bay 41-2272; 5) Expression of mRNA of muscarinic receptors M3 and M2, purinergic P2X1 receptors and L-type Ca2+ channels in detrusor by real-time RT-PCR. Histomorfometric analysis revealed increased bladder weight, volume and wall thickness. Neural tissue density was also higher in diabetic mice, whereas smooth muscle and collagen density were not modified in both groups. Cistometric study revealed increases in bladder capacity and compliance in diabetic group, as well as higher peak pressure, micturition frequency and frequency of non-void contractions. Diabetic mice exhibited enhanced post-void pressure, indicating a decrease in bladder emptying efficiency. Detrusor contractile responses to carbachol, ?,?-methylene ATP, KCl, CaCl2 and EFS were significantly higher in diabetic mice. In order to evaluate the role of L-type Ca2+ channels and rho-kinase in the detrusor hypercontractility, contraction curves to carbacol were performed in the presence of L-type Ca2+ channel blocker nifedipine (3 nM) or the rho-kinase inhibitor Y27632 (1 µM). Pre-incubation with nifedipine prevented the increased carbachol-induced detrusor contractions seen in the diabetic mice, while Y27632 did not significantly affect the detrusor contractions in both groups. Levels of mRNA of M3 receptor and L-type Ca2+ channels were significantly increased in diabetic animals, while M2 and P2X1 mRNA expression were not modified in both groups. Concentration-response curves in urethral smooth muscle revealed an increased contractile response to phenylefrine, and a reduction on the relaxant responses to nitric oxide donor, sodium nitroprusside (SNP), in diabetic group, indicating an enhanced urethral resistance by diabetes. In conclusion, our data shows that the overactive detrusor in diabetes is likely to be due an increase in extracellular Ca2+ influx through L-type Ca2+ channels and an enhanced M3 muscarinic expression. Moreover, the higher urethral mechanical resistance result in decrease of the bladder emptying efficiency in diabetic mice associated to detrusor overactivity
Mestrado
Mestre em Farmacologia
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Tsai, Kathleen. "The Impact of Urinary Incontinence Severity on Direct Healthcare Utilization, Work Productivity, and Clinical Events among Individuals with Overactive Bladder." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/306998.
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Introduction: The purpose of this research was to assess the relationship between the degree of incontinence severity and treatment seeking behavior, healthcare utilization, and work productivity; and to compare overactive bladder (OAB) related disease burden from a global perspective. Methods: A cross-sectional online survey was administered to eligible participants with idiopathic OAB residing in Australia, Canada, France, Germany, Italy, Spain, United Kingdom, and the United States. Participants were categorized into subgroups with dry, mild (1 leak/per day), moderate (2 leaks/day), and severe (3 leaks/day) urinary incontinence (UI) severity groups. Results: A total of 1,334 participants completed the survey. Persons with more severe urinary incontinence symptoms related to OAB consumed more healthcare resources, had a higher occurrence of OAB related clinical consequences, and higher work productivity loss compared to individuals with less severe symptoms. Even though OAB is associated with significant disease burden, many patients do not seek treatment.
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Seth, J. "Tibial Nerve Stimulation for the management of overactive bladder and the measurement of urinary neurotrophins as a biomarker of response to treatment." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1566640/.
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Palma, Thaís Figueiredo 1984. "Influência da idade, do índice de massa corporal e de antecedentes obstétricos nos sintomas da síndrome da bexiga hiperativa em mulheres no menacme = Influence of age, body mass index and obstetric history in the symptoms of overactive bladder in women in menacme." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312545.
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Orientador: Cássio Luis Zanettini RiccettoTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-24T12:04:58Z (GMT). No. of bitstreams: 1 Palma_ThaisFigueiredo_D.pdf: 5188121 bytes, checksum: 3443d8a70ab4644713a51d88beb4d20c (MD5) Previous issue date: 2014
Resumo: Introdução: A Síndrome da Bexiga Hiperativa (BH) é definida pela ICS (International Continence Society) como urgência urinária, acompanhada ou não por incontinência e frequentemente associada ao aumento da frequência urinária e noctúria. Objetivo: O objetivo do estudo foi verificar a influência da idade, do índice de massa corporal (IMC) e de antecedentes gestacionais nos sintomas de bexiga hiperativa em mulheres no menacme. Pacientes e Métodos: No total foram avaliados os questionários preenchidos por 1052 mulheres com idade entre 20 e 45 anos na região de Campinas. Foi utilizado o questionário ICIQ-OAB, uma ferramenta específica para bexiga hiperativa, em sua versão validada em Português e uma ficha de avaliação para dados demográficos e história médica, incluindo: idade, peso, altura, paridade e via de parto. Resultados: De modo geral, mulheres com idade entre 35 e 45 anos apresentaram escore do ICIQ-OAB significativamente maior do que todos os outros grupos (20 a 22; 23 a 27 e 38 a 34) (p<0.0001). Mulheres multíparas e primíparas apresentaram escore significativamente maior do que as nulíparas (p<0,001); e os sintomas não diferiram de acordo com a via de parto - vaginal ou cesárea (p=0.0074). Não foram encontradas diferenças significativas no escore entre os grupos de IMC (<18,5; 18,8 a 24,9; 25 a 29,9 e ? 30) (p=0,0066). Também foram encontradas diferenças significativas com relação ao incômodo causado pelos sintomas. Mulheres de 35 a 45 anos se sentem mais incomodadas do que os outros grupos com relação á frequência (p<0.0001), noctúria (p=0.0011), urgência (p=0.0015) e incontinência por urgência (p<0.0001). O incômodo causado pelos sintomas não diferiu entre os grupos de mulheres nulíparas, primíparas e multíparas (p=0,9363). As mulheres com IMC entre 25 e 29,9 apresentaram incômodo maior do que aquelas com IMC entre 18,5 e 24,9, com relação à incontinência por urgência (p=0,002). Conclusões: Na população estudada de mulheres no menacme, os sintomas de bexiga hiperativa são encontrados mais frequentemente e causam mais incômodo em mulheres com idade mais avançada, índice de massa corporal mais elevado e com histórico de pelo menos uma gestação
Abstract: Introduction: Overactive Bladder Syndrome (OAB) is defined by the ICS (International Continence Society) as urinary urgency, with or without urgency incontinence and frequently associated with increase of frequency and nocturia. Objectives: The aim of the study was to verify the influence of age, body mass index (BMI) and obstetric history in the symptoms of overactive bladder in premenopausal women. Patients and Methods: We analyzed a total of 1052 questionnaires that were filled out by women aged 20-45 in the area of Campinas, SP. We chose the ICIQ-OAB questionnaire, a tool that is specific for overactive bladder, in its Portuguese validated version and na assessment form with demographics and medical history, that included: age, weight, height, parity and mode of delivery (vaginal or cesarean). Results: Overall, women aged 35-45 presented higher scores than all other age groups (20 - 22; 23 - 27 and 38 - 34) (p<0.0001). Multiparous and primiparous women presented higher scores than nulliparous ones (p<0,001); and the symptoms did not differ according to mode of delivery ¿ vaginal or cesarean (p=0.0074). No significant differences were found between the BMI groups - <18,5; 18,8 - 24,9; 25 - 29,9 and ? 30 - (p=0,0066). We also found differences regarding symptom bother. Women aged 35-45 were more bothered than all other groups regarding frequency (p<0.0001), nocturia (p=0.0011), urgency (p=0.0015) and urgency incontinence (p<0.0001). Symptom bother did not differ between nuliparous, primiparous and multiparous women (p=0,9363). Women with BMI 25 - 29,9 were more bothered by urgency incontinence than those with BMI 18,5 - 24,9 (p=0,002). Conclusions: In the premenopausal women population of this study, OAB symptoms were found more frequently and cause more bother in older women, with higher BMI and with history of at least one pregnancy
Doutorado
Fisiopatologia Cirúrgica
Doutora em Ciências
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Silva, Renata Helena José. "Imipramina versus tratamento conservador em mulheres com síndrome da bexiga hiperativa." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/39663.
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A Síndrome da Bexiga Hiperativa (SBH) é caracterizada por urgência urinária com ou sem incontinência, acompanhada de freqüência e noctúria. O tratamento é inicialmente clínico, visando o relaxamento do musculo detrusor com uso de anticolinérgicos e antidepressivos tricíclinos. Os anticolinérgicos reduzem a atividade contrátil do detrusor por bloquear os receptores muscarínicos na junção neuromuscular. A Imipramina é um antidepressivo tricíclico que possui ação anticolinérgica e alfa-adrenérgica indireta, relaxando o detrusor e aumentando a pressão intrauretral, diminuindo os episódios de perda urinária, sendo uma boa alternativa para a Incontinência Urinária Urgência (IUU) e Incontinência Urinária Mista (IUM). OBJETIVOS: Validar a Imipramina como opção para paciente com SBH e verificar a ocorrência e a freqüência dos efeitos adversos. MATERIAIS E MÉTODOS: Ensaio clínico randomizado cruzado com mulheres com mais de 18 anos com queixa de IUU ou IUM atendidas no Ambulatório de Uroginecologia do Hospital de Clínicas de Porto Alegre (HCPA). Para uma melhora de 71% no grupo da imipramina e 16% do grupo dos exercícios perineais, com “p” de 0,05 e um poder de 80%, são necessários 19 pacientes em cada grupo (Epi-Info). Totalizamos um “n” de 38 pacientes, estimando 20% de perdas. RESULTADOS e CONCLUSÕES: 38 mulheres foram randomizadas, sendo 6 pacientes excluídas. 32 pacientes foram submetidas à três meses de tratamento conservador e três meses de uso de Imipramina. Ao final de 6 meses foi realizada a análise estatística. 24 pacientes mantiveram o uso da medicação após o término do estudo. Não houve diferença entre os grupos em relação aos dados demográficos, comorbidades, uso de medicações, cirurgias, distopias genitais, presença de efeitos colaterais com uso da medicação, tempo de suspensão da medicação e Pressão de Perda Urinária (VLPP). Houve diferença estatística em relação à presença de Contrações Não Inibidas (CNI) durante a Avaliação Urodinâmica. Em relação aos questionários, o uso imipramina mostrou uma melhora de 16,8 vezes em relação à alocação quando comparadas com uma melhora de 2,1 vezes do tratamento conservador. Em relação à Percepção Geral da Saúde (PGS), não houve diferença estatística, mas em relação à avaliação do Impacto da Incontinência (II), houve diferença significativa no grupo de realizou tratamento com Imipramina. Demostrou-se uma melhora da perda urinária de 16, 3 vezes quando comparadas ao início da alocação. A análise do escore final mostrou uma significância estatística na interação do grupo com o tipo de tratamento utilizado em determinado momento do tempo. Em conclusão, como única medicação disponível no Sistema Único de Saúde (SUS) para tratar essa patologia podemos passar a utilizá-la, com cautela, como opção terapêutica ao anticolinérgico hoje mais usado, a oxibutinina, uma vez que se mostrou segura em relação aos efeitos colaterais e apresentou significância estatística em relação ao tratamento conservador. Entretanto, acredita-se que mais ensaios clínicos devem ser realizados com um “n” maior de pacientes e, talvez, comparando a imipramina com a oxibutinina, uma vez que é medicação de referência para tal patologia.Overactive Bladder Syndrome (SBH) is characterized by urinary urgency with or without incontinence, accompanied by frequency and nocturia. Treatment is initially clinical, aimed at relaxing the detrusor muscle with the use of anticholinergics, antispasmodics and antidepressants tricíclinos. Anticholinergics reduce the contractile activity of the detrusor muscle by blocking muscarinic receptors at the neuromuscular junction. Imipramine is a tricyclic antidepressant that has anticholinergic action and alpha-adrenergic indirect, relaxing muscles and increasing detrusor pressure intrauretral, reducing the frequency of urinary leakage, being a good alternative for Urgency Urinary Incontinence (IUU) and mixed urinary incontinence (IUM). OBJECTIVES: To validate Imipramine as an option for patients with SBH and to verify the occurrence and frequency of adverse effects. METHODS: A randomized crossover clinical trial, with women over 18 years with complaints of IUU or IUM treated at the Urogynecology Clinic of Hospital de Clinicas de Porto Alegre (HCPA). For an improvement of 71% in the imipramine group and 16% of perineal exercises, with "p" of 0.05 and a power of 80%, 19 patients are needed in each group (Epi-Info). Totaled an "n" of 38 patients, an estimated 20% loss. RESULTS AND CONCLUSIONS: 38 women were randomized, with 6 patients excluded. 32 patients underwent three months of conservative treatment and three months of use of imipramine. At the end of 6 months was performed statistical analysis. 24 patients maintained their use of medication after the study. There was no difference between groups regarding demographics, comorbidities, medication use, surgery, genital dystopias, presence of side effects with the medication, time of drug discontinuation and urinary loss pressure (VLPP). There was statistical difference in relation to the presence of uninhibited contractions (CNI) during urodynamic evaluation. Regarding the questionnaires, the use of imipramine showed an improvement of 16.8 times over the allocation when compared to a 2.1 times improvement in the conservative treatment. Regarding the General Health Perception (PGS), there was no statistical difference, but in relation to assessing the impact of incontinence (II), there was significant difference in the group treated with imipramine performed. Demonstrated to an improvement in urinary loss of 16, 3 times when compared to the beginning of the allocation. The analysis of the final score showed a statistical significance in the group's interaction with the type of treatment used in a given moment in time. In conclusion, as the only medication available in the Brazilian Public Health System (SUS) to treat this disease that affects a substantial number of women, since it proved to be safe in relation to the side and made statistically significant compared to conservative treatment, we can move to use it with caution, as a therapeutic option for today's most commonly used anticholinergic, oxybutynin. However, it is believed that more trials should be conducted with more patients and perhaps comparing imipramine with oxybutynin, because it is a reference for this pathology.
Books on the topic "Overactive Urinary Bladder"
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R, Chapple Christopher, ed. Overactive bladder in clinical practice. London: Springer-Verlag London Ltd., 2012.
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MacDiarmid, Scott A., Jacques Corcos, and John Heesakkers. Overactive bladder: Practical management. Chichester, West Sussex, UK: John Wiley & Sons, 2015.
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Ellsworth, Pamela. Questions & answers about overactive bladder. 2nd ed. Sudbury, Mass: Jones and Bartlett Publishers, 2009.
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Ellsworth, Pamela. Questions & answers about overactive bladder and urinary incontinence. Sudbury, Mass: Jones and Bartlett, 2006.
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Rosenberg, Matt T. Contemporary diagnosis and management of urinary incontinence and overactive bladder. Newtown, Pa: Handbooks in Health Care Co., 2012.
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Corcos, Jacques, Scott MacDiarmid, and John Heesakkers. Overactive Bladder: Practical Management. Wiley & Sons, Incorporated, John, 2015.
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Corcos, Jacques, Scott MacDiarmid, and John Heesakkers. Overactive Bladder: Practical Management. Wiley & Sons, Incorporated, John, 2015.
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Corcos, Jacques, Scott MacDiarmid, and John Heesakkers. Overactive Bladder: Practical Management. Wiley & Sons, Limited, John, 2015.
Find full textBook chapters on the topic "Overactive Urinary Bladder"
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Janes, Sophia, Sara M. Lenherr, and Anne P. Cameron. "Botulinum Toxin for Overactive Bladder." In Female Urinary Incontinence, 193–205. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84352-6_11.
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Parsons, Brian A., and Marcus J. Drake. "Animal Models in Overactive Bladder Research." In Urinary Tract, 15–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16499-6_2.
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Soligo, Marco, and Alessandro Giammò. "Overactive Bladder and Female Stress Urinary Incontinence." In Non-Neurogenic Bladder Dysfunctions, 87–95. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57393-5_7.
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Pesce, Francesco, and Maria Angela Cerruto. "Medical Treatment of Urinary Incontinence, Urinary Retention, and Overactive Bladder." In Pelvic Floor Disorders, 271–76. Milano: Springer Milan, 2010. http://dx.doi.org/10.1007/978-88-470-1542-5_33.
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Purohit, Rajveer S., and Jerry G. Blaivas. "Treatment of Overactive Bladder Refractory to Medications." In Minimally Invasive Therapy for Urinary Incontinence and Pelvic Organ Prolapse, 123–32. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0008-4_11.
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Zullo, Marzio Angelo. "Sacral Nerve Modulation for Urinary Disorders: Overactive Bladder." In Electrical Stimulation for Pelvic Floor Disorders, 137–44. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-06947-0_11.
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Atiemo, Humphrey, and J. Quentin Clemens. "Managing Overactive Bladder and Urinary Incontinence in the Male." In Urological Men’s Health, 129–40. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-900-6_13.
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Robinson, Dudley, and Linda Cardozo. "Pharmacological Treatment of Urinary Incontinence and Overactive Bladder: The Evidence." In Pelvic Floor Disorders, 351–63. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-40862-6_26.
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Peeker, Ralph. "Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia, and Overactive Bladder." In Handbook of Clinical Gender Medicine, 428–37. Basel: KARGER, 2012. http://dx.doi.org/10.1159/000336449.
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Westerik-Verschuuren, Liesbeth, Marjolijn Lutke Holzik-Mensink, Marleen Wieffer-Platvoet, and Minke van der Velde. "Sexual Aspects of Pelvic Floor Disturbances/Disorders." In Midwifery and Sexuality, 185–95. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-18432-1_16.
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AbstractThis chapter will pay attention to the disturbances related to the pelvic floor, focusing on their sexuality-related consequences. It will start with the troubles during pregnancy, followed by the problems after childbirth. At the end of each topic, it will offer treatment recommendations.The urinary disorders will cover stress urinary incontinence (SUI), urgency urinary incontinence (UUI), climacturia (losing urine during orgasm), and urinary tract infections. The defecation disorders will cover anal incontinence, flatal incontinence, and constipation. Pelvic organ prolapse (POP) does usually not happen in the first pregnancy, though the primigravid woman can have similar complaints.Pelvic girdle pain (PGP) tends to start during pregnancy.Pregnancy and vaginal birth are the most common risk factors for postpartum PF disorders: stress urinary incontinence, overactive bladder syndrome, pelvic organ prolapse, and anal incontinence. On the one hand, that may sound like pathologizing childbirth. On the other hand, healthcare providers should be aware that they tend to underestimate the rates of (anal) obstetric injuries, and most textbooks do not mention levator ani avulsion.Aspects of pelvic floor muscle training (PFMT) receive ample attention in the treatment recommendations. In the postpartum part, the chapter pays extra attention to perineal pain, vaginal laxity, and overactive pelvic floor. Those are disruptive elements for intimacy and sexuality, just like all the other mentioned disturbances.This chapter is part of ‘Midwifery and Sexuality’, a Springer Nature open-access textbook for midwives and related healthcare professionals.
Conference papers on the topic "Overactive Urinary Bladder"
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Long, Rebecca A., Aron Parekh, and Michael S. Sacks. "Strain Induced Bladder Smooth Muscle Remodeling." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176289.
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Multiple urinary bladder wall (UBW) pathologies, such as overactive bladder, bladder outlet obstruction, spinal cord injury (SCI) and related neurogenic disorders, and diabetes result in tissue remodeling marked by hypertrophic bladder smooth muscle cells (BSMC) and altered extra-cellular matrix components. This remodeling results in changes in UBW biomechanical properties leading to altered bladder function. Our previous studies have revealed that during the initial areflexic phase of SCI the UBW undergoes profound remodeling that appears to be a compensatory mechanism for the increased wall stretch resulting from over-distension [1, 2]. Remodeling in the bladder wall results in changes in biomechanics and ultimately the ability of the organ to normally fill and void [3]. The stimuli and precise mechanisms that are responsible for bladder remodeling in SCI and the aforementioned pathologies remain unknown. The objective of the present study is to determine the effects of varied in vitro strain on ECM production in the ex vivo rat bladder as a first step toward understanding tissue remodeling in response to strain.
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Celik, Ismail B., Asaf Varol, Coskun Bayrak, and Jagannath R. Nanduri. "A One Dimensional Mathematical Model for Urodynamics." In ASME/JSME 2007 5th Joint Fluids Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/fedsm2007-37647.
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Millions of people in the world suffer from urinary incontinence and overactive bladder with the major causes for the symptoms being stress, urge, overflow and functional incontinence. For a more effective treatment of these ailments, a detailed understanding of the urinary flow dynamics is required. This challenging task is not easy to achieve due to the complexity of the problem and the lack of tools to study the underlying mechanisms of the urination process. Theoretical models can help find a better solution for the various disorders of the lower urinary tract, including urinary incontinence, through simulating the interaction between various components involved in the continence mechanism. Using a lumped parameter analysis, a one-dimensional, transient mathematical model was built to simulate a complete cycle of filling and voiding of the bladder. Both the voluntary and involuntary contraction of the bladder walls is modeled along with the transient response of both the internal and external sphincters which dynamically control the urination process. The model also includes the effects signals from the bladder outlet (urethral sphincter, pelvic floor muscles and fascia), the muscles involved in evacuation of the urinary bladder (detrusor muscle) as well as the abdominal wall musculature. The necessary geometrical parameters of the urodynamics model were obtained from the 3D visualization data based on the visible human project. Preliminary results show good agreement with the experimental results found in the literature. The current model could be used as a diagnostic tool for detecting incontinence and simulating possible scenarios for the circumstances leading to incontinence.
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Champaigne, Kevin D., Sarette N. Jenderny, and Jiro Nagatomi. "Electrophysiological Investigation of Hydrostatic Pressure Mechanotransduction by Urothelial Cell Lines." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53518.
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The urothelium is the epithelial lining of the ureters, urinary bladder, and urethra. Recent discoveries have suggested that in addition to providing a barrier function to urine, the urothelium actively participates in sensory functions related to thermal, chemical, and mechanical stimuli, and releases chemical signals in response[1]. In addition to a sensitivity to cell membrane stretch caused by wall tension upon bladder filling, in vitro studies by our group have shown that urothelial cells may be sensitive to hydrostatic pressure directly without requiring membrane stretching [2]. Specifically, primary cultures of rat bladder urothelial cells exposed to 10 cmH2O pressure on rigid substrates released significantly greater amounts of ATP compared to the baseline control without exposure to pressure. Moreover, this ATP response by rat urothelial cells to pressure was inhibited by pre-treatment of cells with ruthenium red, a non-specific antagonist of transient receptor potential (TRP) channels, suggesting a potential involvement of these channels in pressure mechanotransduction. Further understanding of the mechanisms, however, is needed to improve treatment of bladder dysfunction such as overactive bladder.
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Silva, Ingrid Antunes da, Carlos Augusto Faria, Iris Cardoso de Pádua Terra, Raquel Luiz Queres, Guilherme da Silva Bueno, and Alice Ferreira de Almeida. "Impacto da noctúria na qualidade de vida geral e específica de mulheres atendidas em dois ambulatórios de uroginecologia do Sistema Único de Saúde: um estudo transversal." In 46º Congresso da SGORJ e Trocando Ideias XXV. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/jbg-0368-1416-2022132s1024.
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Introdução: A noctúria é definida pela Sociedade Internacional de Continência (ICS) e pela Associação Uroginecológica Internacional (IUGA) como um ou mais episódios de despertar noturno para urinar, sucedido(s) por um período de sono. Ela possui impacto sobre a qualidade de vida (QV) em algumas populações, principalmente por seus efeitos deletérios sobre o sono. Alguns estudos vêm mostrando que a maioria dos participantes que apresentam uma micção noturna não referem comprometimento da QV. Objetivo: Avaliar o impacto da noctúria sobre a QV geral e específica de pacientes atendidas em dois ambulatórios de uroginecologia do Sistema Único de Saúde. Materiais e métodos: Trata-se de estudo transversal, com amostra de conveniência, que teve como população mulheres com queixas de sintomas do trato urinário baixo. Os critérios de inclusão foram sexo feminino e capacidade cognitiva preservada. Os critérios de exclusão foram idade inferior a 18 anos, gestantes e histórico de radioterapia pélvica, cirurgia para câncer pélvico ou doença neurológica. Foi registrado o número de micções noturnas das participantes em ficha de anamnese e foram aplicados os questionários International Consultation on Incontinence Questionnaire Overactive Bladder Module (ICIQ-OAB), que avalia o impacto de sintomas urinários sobre a QV, e World Health Organization Quality-Of-Life em sua versão abreviada (WHOQOL-bref), que avalia a QV em geral. Calcularam-se os escores de cada um dos domínios do WHOQOL-bref (ambiente, psicológico, físico e social), além da pontuação geral, e foi considerada pior qualidade de vida a pontuação inferior ao percentil 25. Os escores da pergunta 4b do ICIQ-OAB, assim como a escala visual analógica (EVA), foram utilizados para avaliar o impacto específico da noctúria sobre a QV. Foram avaliados dois cenários: o primeiro considerando-se como noctúria um ou mais episódios de micção por noite, e o segundo, dois ou mais episódios por noite. Os testes χ2 e exato de Fisher foram utilizados para avaliar a associação de noctúria com pior QV geral e específica nos dois cenários já descritos. A significância estatística foi definida por p>0,05. Resultados e conclusão: Foram incluídas 59 pacientes na análise. Delas, 77,59% relataram um episódio de noctúria ou mais. Não foi observada associação entre noctúria e piores escores de nenhum dos domínios do WHOQOL-bref. Por outro lado, houve associação estatisticamente significante entre noctúria e piores escores da pergunta 4b e na EVA em ambos os cenários estudados. Assim, na população estudada, a noctúria não traz impacto negativo na QV em geral, mas seu impacto específico é relevante. É possível que tenha contribuído para tal resultado o fato de se tratar de uma população frequentadora de serviços especializados, com múltiplas comorbidades que levam ao comprometimento da QV geral independentemente da presença de noctúria.
Reports on the topic "Overactive Urinary Bladder"
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Leonardo, Kevin, Doddy Hami Seno, Hendy Mirza, and Andika Afriansyah. Biofeedback Pelvic Floor Muscle Training and Pelvic Electrical Stimulation in Women with Overactive Bladder : A Systematic Review and Meta-analysis of Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0024.
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Review question / Objective: Population : Overactive Bladder, Women; Intervention : Biofeedback assisted PFMT and/or pelvic Electrical Stimulation with non-implanted electrodes (on the skin surface around perianal, intra vaginal or rectal); Comparison : PFMT only / Bladder Training / Life style modification-recommendation; Outcome : Changes in Quality of life, Incontinence Episodes, Number of participant cured/improved. Condition being studied: Overactive Bladder syndrome which has been defined as urinary urgency. It is not life threatening disease, therefore, often ignored by patients, but the effect in daily life can be very bothersome.
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Elenkov, Chavdar, Ivo Donkov, Marin Georgiev, and Krassimir Yanev. Comparative Analysis of Newly-developed Overactive Bladder after Surgery for Stress Urinary Incontinence in Women. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, October 2019. http://dx.doi.org/10.7546/crabs.2019.10.15.
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Travis, Amanda, Margaret Harvey, and Michelle Rickard. Adverse Childhood Experiences and Urinary Incontinence in Elementary School Aged Children. University of Tennessee Health Science Center, October 2021. http://dx.doi.org/10.21007/con.dnp.2021.0012.
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Purpose/Background: Adverse Childhood Experiences (ACEs) have an impact on health throughout the lifespan (Filletti et al., 1999; Hughes et al., 2017). These experiences range from physical and mental abuse, substance abuse in the home, parental separation or loss, financial instability, acute illness or injury, witnessing violence in the home or community, and incarceration of family members (Hughes et al., 2017). Understanding and screening for ACEs in children with urinary incontinence can help practitioners identify psychological stress as a potentially modifiable risk factor. Methods: A 5-month chart review was performed identifying English speaking patients ages 6-11 years presenting to the outpatient urology office for an initial visit with a primary diagnosis of urinary incontinence. Charts were reviewed for documentation of individual or family risk factors for ACEs exposure, community risk factors for ACEs exposures, and records where no related documentation was included. Results: For the thirty-nine patients identified, no community risk factors were noted in the charts. Seventy-nine percent of patients had one or more individual or family risk factors documented. Implications for Nursing Practice This chart review indicates that a significant percentage of pediatric, school-aged patients presenting with urinary incontinence have exposure to ACEs. A formal assessment for ACEs at the time of initial presentation would be helpful to identify those at highest risk. References: Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, Koss MP, Marks JS. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the adverse childhood experiences (ACE) study. Am J Prev Med. 1998;14:245–258 Hughes, K., Bellis, M.A., Hardcastle, K.A., Sethi, D., Butchart, D., Mikton, C., Jones, L., Dunne, M.P. (2017) The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis. Lancet Public Health, 2(8): e356–e366. Published online 2017 Jul 31.doi: 10.1016/S2468-2667(17)30118-4 Lai, H., Gardner, V., Vetter, J., & Andriole, G. L. (2015). Correlation between psychological stress levels and the severity of overactive bladder symptoms. BMC urology, 15, 14. doi:10.1186/s12894-015-0009-6