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ABREU, Glícia Estevam de, Eneida Regis DOURADO, Danielle de Novais ALVES, Milly Queiroz de ARAUJO, Natália Souza Paes MENDONÇA, and Ubirajara BARROSO JUNIOR. "FUNCTIONAL CONSTIPATION AND OVERACTIVE BLADDER IN WOMEN: A POPULATION-BASED STUDY." Arquivos de Gastroenterologia 55, suppl 1 (August 21, 2018): 35–40. http://dx.doi.org/10.1590/s0004-2803.201800000-46.
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ABSTRACT BACKGROUND: An association between urinary disorders and functional constipation has been registered in children and adults, with functional constipation being a common complaint in individuals with overactive bladder. OBJECTIVE: To evaluate the prevalence of functional constipation, overactive bladder and its dry/wet subtypes in women and to determine which bowel symptoms predict overactive bladder. METHODS: A cross-sectional study of women randomly approached in public spaces. Exclusion criteria: neurological/anatomical abnormalities of the bowel or urinary tract. Constipation was defined as ≥2 positive symptoms of those listed in the Rome criteria. Urinary abnormalities (frequent urination, urgency, incontinence, nocturia) were defined by a score ≥2 in the respective item of the International Consultation on Incontinence Questionnaire - Overactive Bladder. Dry overactive bladder was defined as urgency without incontinence, while wet overactive bladder included incontinence. RESULTS: A total of 516 women with a mean age of 35.8±6 years were interviewed. Rates of functional constipation, overactive bladder, dry overactive bladder and wet overactive bladder were 34.1%, 15.3%, 8.9% and 6.4%, respectively. Functional constipation was associated with overactive bladder and dry overactive bladder, with functional constipation predicting dry overactive bladder (OR=2.47). Quality of life was poorer in constipated women compared to non-constipated and even worse in constipated women with wet overactive bladder (median 22.5; 95%CI: 17.25-35.25). Manual maneuvers were significantly associated with both overactive bladder subtypes. Independent predictive factors for overactive bladder were manual maneuvers (OR=2.21) and <3 defecations/week (OR=2.18), with the latter being the only predictive factor for dry overactive bladder (OR=3.0). CONCLUSION: Functional constipation is associated with overactive bladder and its dry subtype, particularly in the younger population. In addition, this association is responsible for lower quality of life scores, especially when urinary incontinence is present. The presence of manual maneuvers and less than three defecations per week should direct us to look for overactive bladder.
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Zwierzyńska, Anna. "Overactive bladder." Journal of Education, Health and Sport 11, no. 7 (July 15, 2021): 116–23. http://dx.doi.org/10.12775/jehs.2021.11.07.010.
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Urinary incontinence is a problem among both older and young women. The most common symptoms of this condition include urinary incontinence and an unpleasant odour. In order to conceal the ailments related to this problem, women change their lifestyle by limiting the amount of fluid consumed and not moving too far from home or places where toilets are located. The main source of information on this disease in women aged over 45 is books, magazines and websites. Medical personnel are only ranked behind them. In order to make a correct diagnosis of this disease and to start treatment, urodynamic examination, urinalysis, cystoscopy and imaging examinations should be performed. Urodynamic examination can be divided into two groups: invasive and non-invasive. The micturition diary is considered to be the basic urodynamic test. It allows for performing differential diagnosis of functional micturition disorders. It is characterized by high repeatability and correlation with clinical symptoms. Treatment options are dependent on the type of urinary incontinence. They may include conservative treatment, surgery and pharmacotherapy. Combining conservative methods with pharmacological or surgical methods brings the most beneficial results. Invasive methods are the last-line therapy.
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Hwang, Ye-Chae, Hye-Jin Lee, Hye-Min Heo, Gyu-Ri Jeon, Seung-Yeon Cho, Seong-Uk Park, Chang-Nam Ko, and Jung-Mi Park. "Clinical Report of Baliao Electroacupuncture Treatment on a Stroke Patient Suffering from a Neurogenic Overactive Bladder." Journal of Internal Korean Medicine 43, no. 1 (March 31, 2022): 90–103. http://dx.doi.org/10.22246/jikm.2022.43.1.90.
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Objective: The purpose of this case study is to report the effectiveness of Baliao acupoints electro-acupuncture treatment on a neurogenic overactive bladder induced by stroke.Method: A patient suffering from middle cerebral artery infarction was diagnosed with a neurogenic overactive bladder and treated by Korean medicine, including electro-acupuncture on Baliao acupoints six times per week. The evaluation was performed by monitoring urinary frequency and using the Korean versions of the Overactive Bladder Symptom Score (OABSS) and Urinary Incontinence Quality of Life (I-QoL).Results: After 27 days of electro-acupuncture treatment, the OABSS score improved from 6 to 3. The I-QoL total score improved from 60 to 87. The patient also showed a decrease in nocturia frequency.Conclusion: This case suggests that electro-acupuncture on Baliao acupoints can be effective for overactive bladders due to supra-pontine lesions.
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Utama, Bobby Indra, Widayat Widayat, and Berriandi Arwan. "The Incidence of Overactive Bladder (OAB) in KIA Poly Patients at Pauh Health Center in Padang City Using Overactive Bladder Symptoms Score (OABSS)." JOURNAL OBGIN EMAS 3, no. 2 (November 27, 2019): 55–62. http://dx.doi.org/10.25077/aogj.3.2.55-62.2019.
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Objective : This study looked at the incidence of overactive bladder (OAB) in KIA poly patients at Pauh Health Center in Padang City using Overactive Bladder Symptomps Score (OABSS).Method : This research is descriptive. The sampling technique was purposive sampling by considering inclusion and exclusion criteria. The inclusion criteria were women of ideal reproductive age (20-35 years) who had given birth spontaneously, were not pregnant, did not suffer from neurological disorders, diabetes, post bladder surgery and or urinary tract infections and were not treated with Overactive Bladder (OAB), while the exclusion criteria are not willing to take part in the study. The study was carried out at the KIA Poly of Pauh City Health Center in Padang during January 2019. The variable in this study was Overactive Bladder (OAB).Result : In this study, 97.22% of respondents experienced complaints of overactive bladder (OAB), (97.14%) experienced an urgent complaint, and only a small percentage (2.86%) of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1).Conclusion : Most respondents experienced complaints of overactive bladder (OAB) and urgency, and only a small proportion of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1).Keywords : overactive bladder (OAB), Urgensi,inkontinensia urin, Overactive Bladder Symptom Scores (OABSS).
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Utama, Bobby Indra, Widayat Widayat, and Berriandi Arwan. "The Incidence of Overactive Bladder in KIA Poly Patients at Pauh Health Center in Padang City Using Overactive Bladder Symptoms Score." JOURNAL OBGIN EMAS 3, no. 2 (December 12, 2019): 83–89. http://dx.doi.org/10.25077/aoj.3.2.83-89.2019.
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Objective : This study looked at the incidence of overactive bladder (OAB) in KIA poly patients at Pauh Health Center in Padang City using Overactive Bladder Symptomps Score (OABSS).Method : This research is descriptive. The sampling technique was purposive sampling by considering inclusion and exclusion criteria. The inclusion criteria were women of ideal reproductive age (20-35 years) who had given birth spontaneously, were not pregnant, did not suffer from neurological disorders, diabetes, post bladder surgery and or urinary tract infections and were not treated with Overactive Bladder (OAB), while the exclusion criteria are not willing to take part in the study. The study was carried out at the KIA Poly of Pauh City Health Center in Padang during January 2019. The variable in this study was Overactive Bladder (OAB).Result : In this study, 97.22% of respondents experienced complaints of overactive bladder (OAB), (97.14%) experienced an urgent complaint, and only a small percentage (2.86%) of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1). Conclusion : Most respondents experienced complaints of overactive bladder (OAB) and urgency, and only a small proportion of respondents experienced urinary incontinence. The results of this study indicate that respondents who did not experience complaints of overactive bladder (OAB) were respondents with the smallest parity (parity 1).Keywords: overactive bladder (OAB), Urgensi,inkontinensia urin, Overactive Bladder Symptom Scores (OABSS)
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Kostiuk, I., G. Chayka, and Yu Garnets. "The urethral closure function status in pregnant women suffering from overactive bladder syndrome." HEALTH OF WOMAN, no. 9(135) (November 30, 2018): 66–69. http://dx.doi.org/10.15574/hw.2018.135.66.
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The ultrasound method of investigation was proposed as the first step in the diagnosis of urinary incontinence, since the average value of the thickness of the bladder wall and the size of the urethral sphincter in the works of many urologists are correlated with the presence of overactive bladder. The objective: was to determine the sonographic parameters of the urethral closure in pregnant women with overactive urinary bladder. Materials and methods. In this article, an estimation of such ultrasound signs of the urethral closure apparatus, such as funnel-like urethral enlargement, bladder wall thickness measurement, bladder volume, residual urine volume, were performed. The diagnostic value of the cervical-bulk test in pregnant women with overactive urinary bladder is assessed. The obtained results were compared with the same in healthy pregnant women. Results. The index of bladder wall thickness with age increases, as in women with overactive bladder, and in practically healthy women. However, significantly higher value of this indicator (p<0,001) was found in the group of women with overactive bladder. In the third trimester of pregnancy, a positive cervical-bleb test was found in all patients with overactive bladder. In the group of pregnant women with overactive bladder, significantly less volume of the bladder and increased volume of residual urine, which confirms the world data. Conclusion. Data of spontaneous contractions of detrusor in pregnant women suggest that this indicator is a characteristic diagnostic feature of overactive bladder. Key words: pregnancy, ultrasound examination, urethral closure, overactive bladder.
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Rogowski, Artur, Maria Krowicka-Wasyl, Ewa Chotkowska, Tomasz Kluz, Andrzej Wróbel, Dominika Berent, Paweł Mierzejewski, et al. "Psychiatric History and Overactive Bladder Symptom Severity in Ambulatory Urogynecological Patients." Journal of Clinical Medicine 10, no. 17 (September 3, 2021): 3988. http://dx.doi.org/10.3390/jcm10173988.
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Introduction and hypothesis: A link between psychiatric comorbidities and overactive bladder symptomatology has been suggested by preclinical and clinical studies. Given this, we hypothesized that a psychiatric history and current treatment with psychotropic medications could be related to the severity of overactive bladder and incontinence symptoms in patients referred to a tertiary care urogynecological center. Methods: One hundred and twenty-seven female patients diagnosed with an overactive bladder were screened for a lifetime history of psychiatric disorders and the type and number of psychotropic medications currently taken. The overall severity of overactive bladder symptoms was assessed using the Indevus Urgency Severity Scale. The severity and impact of urinary incontinence on the quality of life were quantified with the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form. Urinary incontinence was further quantified with the aid of the Urinary Distress Inventory-6. The patients were screened for stress urinary incontinence using the Stamey Incontinence Score. Results: A psychiatric history, as well as current use of at least two psychotropic medications, was associated with increased severity of overactive bladder symptoms. A history of depression and current treatment with any selective serotonin reuptake inhibitor was associated with increased severity of stress urinary incontinence symptoms. Current treatment with other psychotropic medications, including sedative-hypnotics and drugs with anticholinergic properties was not related to the severity of overactive bladder and incontinence symptoms.
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Trivedi, Sameer, Pranab Patnaik, Yashpal Ramole, Faiz Ahmed Khan, Ragini Srivastava, and Udai Shankar Dwivedi. "Role of Serum and Urinary Biomarkers in Evaluation and Management of Patients With Overactive Bladder." Clinical Medicine Insights: Urology 12 (January 2019): 117956111986490. http://dx.doi.org/10.1177/1179561119864907.
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Background: This study compared urinary and serum nerve growth factor levels and serum C-reactive protein levels in patients with overactive bladder, before and after treatment with antimuscarinic agents, to evaluate their diagnostic and therapeutic importance. Methods: This was a prospective case-control study conducted between February 2014 and December 2014 which included patients with a confirmed diagnosis of overactive bladder (overactive bladder group) and healthy controls (control group). All patients visiting urology out-patient department with urgency, frequency, and urge incontinence were assessed for overactive bladder and, if eligible, were enrolled in the study. Biomarkers were evaluated before in both groups and after antimuscarinic treatment in the overactive bladder group. Results: Overall, 80 participates were enrolled (overactive bladder, n = 40; control, n = 40). The mean age was not different between the two groups (overactive bladder, 48.6 years; control, 46.9 years [ P = 1.01]) and females were more in both the groups (60% and 55%, respectively). The majority (70%) of patients presented with frequency and urgency. After 3 months of treatment with antimuscarinics, the mean overactive bladder symptom score decreased significantly from 8.4 to 4.85 ( P < .001). The mean urinary and serum nerve growth factor levels and serum C-reactive protein levels also decreased significantly from baseline after 3 months of treatment with antimuscarinics (24.78 pg/mL, 22.46 pg/mL, 0.89 mg/L, respectively; P < .0001). Conclusions: Measurement of urinary and serum nerve growth factor levels has diagnostic and therapeutic potential in patients with overactive bladder.
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Kuzmin, Igor V., Margarita N. Slesarevskaya, and Viktoria V. Romikh. "Overactive bladder, inflammation and urinary tract infection: pathogenetic parallels." Urology reports (St. - Petersburg) 14, no. 1 (March 29, 2024): 65–79. http://dx.doi.org/10.17816/uroved627461.
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The review is devoted to modern ideas about the role of inflammation and urinary tract infection in the pathogenesis of overactive bladder. The molecular mechanisms of the mechanosensory function of the urothelium and the influence of bacterial colonization of the urothelium on it are described in detail. It has been shown that infectious inflammation, even in the absence of clinical symptoms, enhances the urothelial response to stretching and increases the excitability of afferent nerves. Bladder hypersensitivity and increased detrusor activity are pathogenetic basis for the development of overactive bladder. Data on the relationship between urinary infection and refractory overactive bladder are presented. The feasibility of conducting extended microbiological studies in patients with overactive bladder , especially when standard therapy is ineffective, has been demonstrated. A pathogenetic rationale for prescribing anti-inflammatory and immunoactive drugs to patients with overactive bladder is presented.
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Subhan, Sana, Syed Imran Ahmad, Muhammad Hammad Ali Mithani, Aftab Ahmed Mirza Baig, Muhammad Kashif, and Muhammad Arif Siddiqui. "Effects of transcutaneous tibial nerve stimulation for overactive bladder symptoms in adults: A randomized controlled trial." Rehabilitation Journal 07, no. 03 (September 30, 2023): 36–41. http://dx.doi.org/10.52567/trehabj.v7i03.7.
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Background: Overactive bladder (OAB) is characterized by urinary urgency, frequency, and nocturia, often accompanied by urinary incontinence. OAB significantly impacts the quality of life of affected individuals. Transcutaneous Tibial Nerve Stimulation (TTNS) is a non-invasive treatment option used to manage overactive bladder (OAB) symptoms. Objective: to determine the effects of Transcutaneous Tibial Nerve Stimulation on overactive bladder symptoms in adults. Methods: A randomized controlled trial was held at the Sindh Institute of Physical Medicine and Rehabilitation with a non-probability purposive sampling technique. After screening for inclusion criteria 60 patients were randomly allocated into two Group A received Transcutaneous tibial nerve stimulation (TTNS) combined with traditional physiotherapy, while Group B just received traditional physiotherapy. Both interventions were given for six weeks. The overactive Bladder Symptom Score was used as an outcome measure tool. Results: Group A improved in all OAB parameters, including daytime frequency (p=0.008), nocturia (p=0.006), urinary urgency (p=0.002), and urge urinary incontinence (p=0.008) with a significant improvement p<0.05. All OABSS parameters in group B also showed a considerable improvement (p<0.05), except for urge urinary incontinence (p=0.08). Conclusion: the daytime frequency, nocturia, and urgency parameters of the overactive bladder symptoms score significantly decreased in both the TTNS+PFM group and the Traditional physiotherapy group. However, urge urinary incontinence showed significant improvement only in the TTNS+PFM group.
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Lee, Hyo Serk, and Ju Tae Seo. "Urinary incontinence and overactive bladder." Journal of the Korean Medical Association 58, no. 10 (2015): 886. http://dx.doi.org/10.5124/jkma.2015.58.10.886.
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Tian, Xiao-Jun, Chang Liu, Ke Liu, and Shi-Ying Tang. "Urinary biomarkers of overactive bladder." Chinese Medical Journal 132, no. 9 (May 2019): 1104–6. http://dx.doi.org/10.1097/cm9.0000000000000214.
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Khadke, Juilee, and Abha Dhupkar. "Prevalence of Overactive Bladder Syndrome Among Adult Females Having Stress Urinary Incontinence and Urge Urinary Incontinence Using Overactive Bladder Syndrome Questionnaire." International Journal of Health Sciences and Research 13, no. 3 (March 6, 2023): 55–68. http://dx.doi.org/10.52403/ijhsr.20230306.
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Objectives: To identify the proportion of OABs using OABs-q in adult females classified as SUI or UUI based on the results of the questionnaire for female urinary incontinence diagnosis (QUID). Material and Methods: 243 females of age group 18-55 years were screened for incontinence, of which 102 were included in the study. Questionnaire for Urinary Incontinence Diagnosis and Overactive Bladder questionnaires were administered and the type of incontinence of the women was identified. Proportion of OAB was identified in SUI, UUI and MUI. Results: 102 out of 240 had incontinence, of which 41 women had SUI, 30 had UUI and 31 had MUI. Proportion of OAB was 17%, 60% and 87% respectively in SUI, UUI and MUI. Conclusion: Overactive bladder syndrome has a higher proportion amongst women showing mixed urinary incontinence. Key words: Stress urinary incontinence, Urge urinary incontinence, Mixed urinary incontinence, Overactive Bladder syndrome, QUID, OAB-q.
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Wallace, Karen M., and Marcus J. Drake. "Overactive bladder." F1000Research 4 (December 7, 2015): 1406. http://dx.doi.org/10.12688/f1000research.7131.1.
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Overactive bladder syndrome is highly prevalent, and increasingly so with aging. It is characterized by the presence of urinary urgency, and can be associated with incontinence, increased voiding frequency, and nocturia. Assessment needs to exclude serious medical disorders that might present with similar symptoms, and a bladder diary is an invaluable part of understanding the presentation. Initial management is conservative, comprising education, bladder training, and advice on fluid intake. Drug therapy options include antimuscarinic medications and beta-3 adrenergic receptor agonists. Persistent overactive bladder syndrome, despite initial therapy, requires a review of the patient’s understanding of conservative management and compliance, and adjustment of medications. For refractory cases, specialist review and urodynamic testing should be considered; this may identify detrusor overactivity or increased filling sensation, and needs to exclude additional factors, such as stress incontinence and voiding dysfunction. Botulinum neurotoxin-A bladder injections can be used in severe overactivity, provided the patient is able and willing to do intermittent self-catheterisation, which is necessary in about 5% of treated patients. Sacral nerve stimulation and tibial nerve stimulation are other approaches. Major reconstructive surgery, such as augmentation cystoplasty, is rarely undertaken in modern practice but remains a possibility in extreme cases.
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Tamburro, Fabiola R., Pietro Castellan, Fabio Neri, Francesco Berardinelli, Maida Bada, Petros Sountoulides, Nicola Giuliani, Enrico Finazzi Agrò, Luigi Schips, and Luca Cindolo. "Onabotulinumtoxin-A improves health status and urinary symptoms in subjects with refractory overactive bladder: Real-life experience." Urologia Journal 85, no. 4 (March 28, 2018): 163–68. http://dx.doi.org/10.1177/0391560318759258.
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Objective: Onabotulinumtoxin-A has been approved for wet overactive bladder refractory to anticholinergics in randomised controlled trials; however, data from real-life practice are scarce. This study was designed to assess the efficacy of intravesical onabotulinumtoxin-A injections, focusing on health status, urinary symptoms and subjective satisfaction. Methods: Data from consecutive patients with overactive bladder-refractory to anticholinergics treated with onabotulinumtoxin-A were prospectively collected and analysed. Standard doses (100–150 U) were used, followed by repeat sessions when clinical benefits diminished. Efficacy and safety of repeat onabotulinumtoxin-A administrations were assessed at 12-week post-injection. Clinical parameters evaluated were: change in the magnitude and frequency of incontinence, urgency and nocturia episodes, change in the number of pads used and procedural complications. Quality of life was evaluated using the 36-Item Short-Form Health Survey, Overactive Bladder Screener and Treatment Benefit Scale questionnaires. Results: Consecutive overactive bladder-refractory to anticholinergics patients ( n = 22) (median duration of oral therapy: 10 months) were enrolled. No intraoperative complications occurred, but two urinary retention cases were recorded. Forty-five percent of patients (10/22) were re-treated (median duration of perceived benefits: 18 months, range: 8–55 months). The number of urinary incontinence, frequency and nocturia episodes, and pads used went from 3.6, 11.3, 2.7 and 2.4 preoperatively to 1.0, 5.8, 0.7 and 0.7 postoperatively ( p < 0.005). Quality of life (36-Item Short-Form Health Survey) was significantly improved and symptom scores (Overactive Bladder Screener) were reduced, from 34.5 to 17.1 at week 12 ( p < 0.05). Eighty-seven percent of patients indicated improvement/great improvement in their condition (Treatment Benefit Scale). Conclusion: Intradetrusor injections of onabotulinumtoxin-A in patients with overactive bladder-refractory to anticholinergics significantly improved health status and urinary symptoms, with high subjective satisfaction.
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Amirov, А. R., R. A. Bodrova, and A. D. Zakamyrdina. "Modern Methods of Overactive Bladder Correction in Patients with Spine Traumas." Doctor.Ru 20, no. 4 (2021): 61–66. http://dx.doi.org/10.31550/1727-2378-2021-20-4-61-66.
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Objective of the Review: To analyse the modern methods of overactive bladder correction in patients with spine traumas. Key Points. A review of publications on the modern methods of overactive bladder correction in patients with spine traumas is presented. Information on the therapy efficacy and possible complications are discussed. Conclusion. Complex correction of overactive bladder plays a vital role in urine retention mechanism, prevents secondary infections, kidney and upper urinary tract transformations, and facilitates social rehabilitation and improved quality of life of patients. Keywords: neurogenic bladder, detrusor overactivity, spine trauma, correction of inappropriate urination.
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Pachowska, Kinga Marlena, Aleksandra Zakrzewska, and Katarzyna Jobs. "Urinary levels of neurotrophic factors (NGF and BDNF) in patients with detrusor overactivity." Pediatria i Medycyna Rodzinna 19, no. 3 (December 5, 2023): 163–68. http://dx.doi.org/10.15557/pimr.2023.0030.
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Overactive bladder refers to a group of urinary symptoms involving urinary urgency accompanied by pollakiuria or day time and nocturnal enuresis. Urodynamic testing is the gold standard for diagnosing the most frequent form of overactive bladder that is detrusor overactivity. Neurotrophins (nerve growth factor – NGF, brain-derived neurotrophic factor – BDNF, neurotrophin 3 – NT-3, and neurotrophin 4 – NT-4) are proteins secreted by the nervous system, found in many tissues, including bladder cells. They are bound by two types of receptors: low- and high-affinity receptors, two of which, i.e. tropomyosin receptor kinase A (TrkA) and p75 receptor, are located in the epithelial cells of the urinary bladder. The detrusor muscle was shown to secrete NGF in response to stretching of the urinary bladder. In addition, numerous studies have shown an increase in the urinary levels of NGF and BDNF in patients with overactive bladder and their decrease after the introduction of anticholinergic therapy. Therefore, the assessment of urinary levels of neurotrophins NGF and BDNF seems to be useful as a potential biomarker of detrusor overactivity. Unfortunately, the sensitivity of these parameters in the diagnosis of detrusor overactivity is low due to the possible overlapping of other conditions, especially bladder pain syndrome, which affects mainly adults. Additionally, previous studies have been conducted in small groups of patients, therefore studies in a larger population are needed. Confirming the usefulness of these biomarkers in the future opens the opportunity to replace the urodynamic test with the analysis of urinary markers, which would significantly simplify diagnosis and increase patient’s comfort.
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Hohlbrugger, G. "Urinary potassium and the overactive bladder." BJU International 83, S2 (May 27, 2002): 22–28. http://dx.doi.org/10.1046/j.1464-410x.83.s2.8.x.
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Lecci, Alessandro, and Carlo Alberto Maggi. "Overactive urinary bladder: Targeting sensory pathways." Drug Discovery Today: Therapeutic Strategies 2, no. 1 (March 2005): 15–23. http://dx.doi.org/10.1016/j.ddstr.2005.05.007.
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Nitti, Victor. "Clinical testing for overactive bladder." Canadian Urological Association Journal 5, no. 5-S2 (April 15, 2013): 137. http://dx.doi.org/10.5489/cuaj.712.
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While the diagnosis of overactive bladder (OAB) is made clinically,simple office testing (e.g., urinalysis and culture, assessmentof post-void residual urine) should be part of the work-up of allpatients with these symptoms. There are certain situations in whichtesting should be undertaken before initiating treatment or for monitoringresponse. Supplemental testing should be considered incases where routine evaluation raises the suspicion of a problemor condition that either needs further evaluation or may predisposethe patient to failure of therapy. Further testing may also be consideredfor patients who are refractory to treatment and those withsignificant neurological disease. Depending on the particular case,supplemental testing may include comprehensive urodynamic testing,endoscopic evaluation of the lower urinary tract, imaging ofthe upper urinary tract, neurologic evaluation or spine imaging.
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Ciećwież, Sylwester, Kornel Chełstowski, Agnieszka Brodowska, Magdalena Ptak, Dariusz Kotlęga, and Andrzej Starczewski. "Association between the Urinary Bladder Volume and the Incidence of “De Novo” Overactive Bladder in Patients with Stress Urinary Incontinence Subjected to Sling Surgeries or Burch Procedure." BioMed Research International 2019 (February 12, 2019): 1–6. http://dx.doi.org/10.1155/2019/9515242.
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Aim. The aim of the study was to compare the incidence of “de novo” overactive bladder (OAB) after sling surgeries and Burch procedure and to analyze the effect of the preoperative bladder volume on the incidence of this condition. Methods. This prospective trial included 290 female patients with stress urinary incontinence (SUI) who were subjected to sling surgeries (TOT or TVT, n=170) or Burch procedure (n=120). Urodynamic testing was performed prior to the surgery and 6 months thereafter. The presence of OAB was diagnosed on the basis of subjective symptoms and urodynamic parameters. Results. The incidence of OAB 3 at 6 months postsurgery was the highest in patients who were subjected to the Burch procedure (14.2% and 17.5%, respectively). The incidence of OAB at 6 months turned out to be significantly higher in patients subjected to the Burch procedure with preoperative bladder volumes greater than 353 ml. We observed the significant postoperative decrease in the bladder volume of women who developed this complication following the Burch procedure. Conclusions. Among surgeries for stress urinary incontinence, Burch procedure is associated with the greatest risk of overactive bladder development. Probably, one reason for the higher incidence of overactive bladder after Burch procedure is the intraoperative reduction of the urinary bladder volume.
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Koch, Marianne, Pavel Lyatoshinsky, Goran Mitulovic, Barbara Bodner-Adler, Sören Lange, Engelbert Hanzal, and Wolfgang Umek. "Characteristics of the Urinary Proteome in Women with Overactive Bladder Syndrome: A Case-Control Study." Journal of Clinical Medicine 10, no. 11 (May 31, 2021): 2446. http://dx.doi.org/10.3390/jcm10112446.
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Despite an estimated prevalence of 13% in women, the exact etiology of non-neurogenic overactive bladder syndrome is unclear. The aim of our study was to gain a better understanding of the pathophysiology of female overactive bladder syndrome by mapping the urinary proteomic profile. We collected urine samples of 20 patients with overactive bladder syndrome and of 20 controls. We used mass spectrometric analysis for label-free quantitation, Swissprot human database for data search, Scaffold for data allocation and the Reactome Knowledgebase for final pathway enrichment analysis. We identified 1897 proteins at a false discovery rate of 1% and significance level p < 0.001. Thirty-seven significant proteins of the case group and 53 of the control group met the criteria for further pathway analysis (p < 0.0003 and Log2 (fold change) >2). Significant proteins of the overactive bladder group were, according to the 25 most relevant pathways, mainly involved in cellular response to stress and apoptosis. In the control group, significant pathways mainly concerned immunological, microbial-protective processes and tissue- elasticity processes. These findings may suggest a loss of protective factors as well as increased cellular response to stress and apoptosis in overactive bladder syndrome.
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Borawski, Dorota, Martin H. Bluth, and Wellman W. Cheung. "Prevalence of urinary incontinence and other lower tract urinary symptoms in patients with uterine myomas." Urogynaecologia 25, no. 1 (December 20, 2011): 18. http://dx.doi.org/10.4081/uij.2011.e18.
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To study the prevalence and risk factors of the overactive bladder, urinary incontinence and other lower tract urinary symptoms in patients with uterine myomas, female patients with established diagnosis of the uterine myomas presenting to gynecology clinic were invited to answer a self-administered questionnaire, which included questions on evidence of lower urinary tract symptoms [modified Overactive Bladder-Validated 8-question Screener (OAB-V8)]. Demographic data, relevant medical and surgical history, and pelvic ultrasound findings were reviewed from the patients charts. Statistical significance of relationship between OAB, stress incontinence and urge incontinence in relation to body mass index (BMI), uterine volume and size of dominant myoma were analyzed using 2-taild exact Fisher test and Wilcoxon test. Ninty-eight patients (28 to 81 years) completed the questionnaire over a period of 3 months. The majority were premenopausal and had detectable myomas on ultrasound. OAB was present in 47.9% women. No significant statistical relation between size and volume of the uterus and overactive bladder, urge incontinence, stress incontinence and mixed incontinence was noted. Observation of OAB subtypes with urge and stress incontinence in premenopausal patients with uterine myomas was statistically significant in comparison with premenopausal women studied (60.8% <em>vs</em> 15.3 and 63% <em>vs</em> 6.8, respectively; P<0.001). Overall prevalence of OAB was similar in both groups. Our study showed the higher prevalence of overactive bladder than in the general population, however overall OAB prevalence related to fibroids did not show statistical significance. OAB-stress incontinence and OABurge incontinence subtypes were associated with uterine myomas.
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Yoon, Hana. "Chronic bladder diseases: overactive bladder and interstitial cystitis/bladder pain syndrome." Journal of the Korean Medical Association 64, no. 11 (November 10, 2021): 763–69. http://dx.doi.org/10.5124/jkma.2021.64.11.763.
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Background: Overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS) are debilitatingchronic bladder diseases that affect patients’ quality of life. Their etiologies and clinical phenotypes vary, and management strategies should be selected after excluding the possibilities of other pathological conditions with careful consideration of a multidisciplinary integrated approach to ensure optimal success.Current Concepts: OAB is a symptom complex characterized by urinary urgency and frequency and nocturia with or without urge incontinence, and its key symptom is urinary urgency. IC/BPS has symptoms similar to lower urinary tract symptoms (LUTS) associated with OAB but also has distinctly different symptoms, including the key symptom of an unpleasant sensation or pain perceived to be related to the urinary bladder associated with LUTS. Recent studies have revealed that these key symptoms of OAB or IC/BPS are also observed in some patients with other diseases. Patients showing no evidence of bacterial infection on urine culture and experiencing LUTS or pain for more than 6 weeks should be considered as having OAB or IC/BPS. Treatment strategies for OAB and IC/BPS focus on managing LUTS and bothersome pain. Noninvasive management should be considered initially, whereas surgical options should be considered only after conservative treatment failure.Discussion and Conclusion: OAB and IC/BPS symptoms overlap considerably in many patients. A more accurate differentiation of symptoms, including LUTS, would help achieve better treatment outcomes.
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Prashchaev, K. I., A. N. Ilnitski, A. A. Pranovich, G. I. Gurko, and A. N. Selivanov. "Patterns of activation of vanilloid and purinergic receptors of the bladder urothelium in elderly with hyperfunction of urothelium, atherosclerosis and their combination." Journal of Clinical Practice 9, no. 2 (December 5, 2018): 30–35. http://dx.doi.org/10.17816/clinpract09230-35.
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This article describes the patterns of activation of vanilloid and purinergic receptors in the bladder tissue in males of different ages. Based on the obtained data, the conclusions are made about the prospects of using activation of these receptors as predictors of certain diseases of the male urinary tract, such as idiopathic increased activity of the bladder (overactive bladder) and as biological markers for evaluating the effectiveness of treatment in the combination of idiopathic overactive bladder and atherosclerotic changes of general nature.
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Demirbas, Arif, Hasmet Sarici, M. Fatih Kilinc, Onur Telli, Berat Cem Ozgur, Omer Gokhan Doluoglu, and Selen Bozkurt. "The Relationship between Acidic Urinary pH and Overactive Bladder; Alkalization of Urine Improves the Symptoms of Overactive Bladder." Urologia Internationalis 95, no. 2 (2015): 223–26. http://dx.doi.org/10.1159/000375322.
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Background: To determine association between urine pH and OAB symptoms and to determine if urinary alkalization improves overactive bladder (OAB) symptoms. Methods: 659 patients with OAB were enrolled in this study between June 2012 and May 2014. 329 patients (group 1) were included in the final analysis. 201 adults were used as a control group (group 2). 24-hour urinary pH and the validated Turkish version of the OAB-V8 questionnaire were performed in patients. A 24-hour urine pH <6.2 was considered acidic urine. In the second part, a diet program was performed for 4 weeks in 30 participants. Urine pH values and OAB-V8 scoring results were recorded before the diet program and 2 and 4 weeks after the diet program. Results: Acidic urinary pH was determined in 61.4% of patients with OAB. There was a significant association between the presence of acidic urine and OAB. Also, the OAB-V8 scores of patients were significantly higher in patients with acidic urine than nonacidic urine. OAB-V8 scores of patients showed statistically significant improvement after diet therapy (17.87 ± 6.52 vs. 10.43 ± 7.17; p < 0.001). Conclusions: We found that acidic urinary pH was closely associated with OAB, and alkalization of urine improved lower urinary tract symptoms. We suggest that urinary pH should be considered as a parameter in treatment planning of patients with OAB.
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Saptarshi Bhattacharya, Arbinder Kumar Singal, and Sanjay Kalra. "The endocrinology of the urinary bladder." Journal of the Pakistan Medical Association 73, no. 12 (November 28, 2023): 2488–90. http://dx.doi.org/10.47391/jpma.23-100.
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The urinary bladder primarily functions as a reservoir for urine. Apparently, it serves only a mechanical and passive role in the urinary tract, but closer scrutiny reveals that it has several meaningful endocrine interactions. This vital organ has an intricate plexus of neurons that release neurohormones concerned with the functioning of the bladder. Endocrine disorders, most notably diabetes, can cause a broad spectrum of bladder dysfunction. The current review explores the bladder as a source of neurotransmitters, a target for organ damage due to uncontrolled endocrinopathy, a beneficiary of hormonal therapy, and a tool to improve endocrine health. Keywords: Urinary bladder, diabetes, lower urinary tract symptoms, overactive bladder, urinary obstruction
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Takara, Tsuyoshi, Kazuo Yamamoto, Naoko Suzuki, and Hiroshi Shimoda. "Seaberry extract with ursolic acid improves anxiety about urinary dysfunction in Japanese adults." Functional Foods in Health and Disease 7, no. 12 (December 31, 2017): 901. http://dx.doi.org/10.31989/ffhd.v7i12.385.
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Background: The seaberry is a yellow berry cultivated in China, Northern Europe, and West Asian countries. Numerous biological activities of seaberries have been reported, and we recently found that ursolic acid and a flavonoid in seaberry extract (SBE) suppressed the contraction of bladder muscle specimens and collagen gel containing bladder smooth muscle cells. However, the influence of SBE on urinary problems of Japanese adults has not been investigated. Therefore, we conducted a clinical trial of SBE supplementation in Japanese subjects with mild urinary dysfunction.Methods: We examined the effect of SBE (200 or 400 mg daily) containing ursolic acid (0.18 or 0.36 mg) in a randomized double-blind placebo-controlled study. Capsules containing SBE or placebo were administered for 8 weeks to Japanese men and women with mild urinary dysfunction. After 4 and 8 weeks of treatment, urinary symptoms were evaluated by using the King’s Health Questionnaire (KHQ) and the overactive bladder syndrome score (OABSS).Results: There was significant improvement of the KHQ emotion domain score after intake of 400 mg/day of SBE for 8 weeks compared with placebo. The answers to “Does your bladder problem make you depressed?” and “Does your bladder problem make you feel bad about yourself?” were significantly improved by SBE (400 mg/day) at 8 weeks. In the OABSS, the item “How often do you have a sudden desire to urinate, which is difficult to defer?” was significantly improved by SBE compared with placebo. Laboratory tests did not reveal any abnormalities suggesting adverse effects SBE. Conclusions: Intake of SBE (400 mg/day for 8 weeks) improved several emotional parameters related to urinary dysfunction. SBE may be useful for reducing moderate urinary symptoms.Keywords: King’s health questionnaire; overactive bladder syndrome score; seaberry; ursolic acid; overactive bladder; urination; micturition
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Juszczak, Kajetan, Adam Ostrowski, Jan Adamowicz, Piotr Maciukiewicz, and Tomasz Drewa. "Urinary bladder hypertrophy and overactive bladder determine urinary continence after radical prostatectomy." Advances in Clinical and Experimental Medicine 28, no. 10 (March 14, 2019): 1329–37. http://dx.doi.org/10.17219/acem/104532.
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Hakimi, Sevil, Elham Aminian, Sakineh Mohammad Alizadeh Charandabi, Parvin Bastani, and Marzieh Mohammadi. "Risk factors of overactive bladder syndrome and its relation to sexual function in menopausal women." Urologia Journal 85, no. 1 (February 2018): 10–14. http://dx.doi.org/10.1177/0391560317750484.
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Background: Overactive bladder syndrome is a common and annoying complication worldwide that could negatively affect the quality of life of afflicted individuals. We aimed to determine the prevalence and risk factors of overactive bladder syndrome and its relation to sexual function in healthy menopausal women. Methods: This cross-sectional study was done on 340 women aged 45-60 years in Tabriz, northwest Iran, during 2015-2016. Data were collected using a demographic data questionnaire, the Overactive Bladder Syndrome Score, and the McCoy Female Sexuality Questionnaire. Results: Fifty-six (16.5%), 63 (18.5%), and 10 (2.9%) of the participating women had mild, moderate, and severe overactive bladder syndrome, respectively. Predictors of overactive bladder included: night sweats, central prolapse, episiotomy, varicose disease, illiteracy or education at the primary level, systolic blood pressure >140 mmHg and lack of physical activity. We found a significant difference between the women with and without overactive bladder with respect to the total score and sub-domain scores related to sex partner (p = 0.029) and sexual interest (p = 0.049). Conclusions: The prevalence of overactive bladder was quite high in this study. Since sexual dysfunction is not an easy topic to talk about and can affect women’s quality of life, physicians should consider talking about these issues besides urinary issues to all middle-aged women.
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Araklitis, George, Georgina Baines, Ana Sofia da Silva, Dudley Robinson, and Linda Cardozo. "Recent advances in managing overactive bladder." F1000Research 9 (September 11, 2020): 1125. http://dx.doi.org/10.12688/f1000research.26607.1.
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Overactive bladder syndrome (OAB) is defined as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency incontinence, in the absence of urinary tract infection or other obvious pathology. In this review, we focus on recent advances in the management of OAB. We examine the evidence on the effect of anticholinergic load on OAB patients. Advances in medical treatment include a new beta-3 agonist, vibegron, which is thought to have fewer drug interactions than mirabegron. Treatment of genitourinary syndrome of the menopause with oestrogens and ospemifene have also shown promise for OAB. Botulinum toxin has been shown to be an effective treatment option. We discuss the new implantable neuromodulators that are on the market as well as selective bladder denervation and laser technology.
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Son, H. S., M. B. Gamo, J. E. Heo, K. T. Oh, and J. H. Kim. "Overactive bladder after artificial urinary sphincter implantation." European Urology Supplements 16, no. 3 (March 2017): e1218-e1220. http://dx.doi.org/10.1016/s1569-9056(17)30759-5.
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Nazarko, Linda. "Lower urinary tract symptoms: Overactive bladder syndrome." Independent Nurse 2018, no. 6 (June 2, 2018): 19–26. http://dx.doi.org/10.12968/indn.2018.6.19.
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Wiatr, Tomasz, and Piotr Chłosta. "Management of urinary incontinence in women with overactive bladder in urologist daily practice." Medycyna Faktów 14, no. 2 (June 30, 2021): 169–75. http://dx.doi.org/10.24292/01.mf.0221.5.
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Urinary incontinence urinary incontinence is common among women and contributes to decreased quality of life. Several effective treatment options are available for the most common types of urinary incontinence (stress, urge, and mixed), including lifestyle modification and behavioral technique, drug therapy, and minimally invasive procedures. Most women improve with treatment, and urinary incontinence is not an inevitable part of aging. To maximize the opportunity for successful treatment, it is essential to align the therapeutic approach with patient goals and expectations for care, including an assessment of patient-driven priorities regarding potential adverse effects, costs, and expected benefit of different treatment approaches. There are many unique challenges in treating an overactive bladder in older women, such as functional and cognitive impairment, multimorbidity, polypharmacy, and estrogen deficiency, all of which contribute to treating symptoms in older women. This review highlights the current understanding of age-related changes in bladder function and proposes specific clinical considerations for overactive bladder management specific to older women.
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Zonić-Imamović, Maida. "EFFECTS OF TREATING AN OVERACTIVE URINARY BLADDER IN PATIENTS WITH MULTIPLE SCLEROSIS." Acta Medica Academica 48, no. 3 (December 31, 2019): 271–77. http://dx.doi.org/10.5644/ama2006-124.267.
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Palmer, Sarah Jane. "Overview of Urinary Incontinence." British Journal of Community Nursing 28, no. 8 (August 2, 2023): 410–12. http://dx.doi.org/10.12968/bjcn.2023.28.8.410.
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Urinary incontinence is a common condition, which affects approximately 300 million people globally. In the UK alone, over 7 million people are affected by this condition. There are various physiological factors that contribute to incontinence, such as a weak bladder, weak pelvic floor muscles, overactive bladder muscles, merve damage from muscle sclerosis, diabetes—to name a few. In this article, the author discusses how urinary incontinence can be managed in men and women, alongside mental health considerations.
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Ballaro, Andrew. "The Elusive Electromyogram in the Overactive Bladder: A Spark of Understanding." Annals of The Royal College of Surgeons of England 90, no. 5 (July 2008): 362–67. http://dx.doi.org/10.1308/003588408x301217.
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It has been said that a technique capable of recording a urinary bladder electromyogram could be useful in the clinical evaluation of the detrusor neuropathies and myopathies implicated in the generation of lower urinary tract symptoms. However, in contrast to electromyography of skeletal and cardiac muscle, detrusor smooth muscle electromyography has remained in its infancy despite 50 years of scientific effort. The principal problems appear to be isolation of the real signal from artefacts, and the doubtful existence of electromyographic activity during cholinergic muscle contraction. The discovery of purinergic neuromuscular transmission in the overactive human bladder has renewed interest in detrusor electromyography as, in contrast to cholinergic mechanisms, purinergic mechanisms can generate extracellular electrical activity. In this paper, the development and validation of a novel technique for recording electrical activity from neurologically intact guinea-pig and human detrusor in vitro is described. A purinergic electromyographic signal is characterised and it is shown that detrusor taken from overactive human bladders has a greater propensity to generate electromyographic activity than normal by virtue of an aberrant purinergic mechanism.
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AYDIN ÖZKAN, Semiha, and Nezihe KIZILKAYA BEJİ. "THE EFFECTS OF FLUID INTAKE HABITS OF THE HEALTHY YOUNG POPULATION ON URINARY SYMPTOMS." INTERNATIONAL REFEREED ACADEMIC JOURNAL OF SPORTS, no. 45 (2022): 0. http://dx.doi.org/10.17363/sstb.2022/abcd89/.45.8.
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Aim: The aim of this study is to evaluate of fluid intake habits and urinary symptoms in young, healthy population. Method: This study design was descriptive, cross-sectional type. A questionnaire was used to assess the fluid intake habits and The Urinary Symptom Profile (USP) (it is structure of 13 items in 3 dimensions: stress urinary incontinence, overactive bladder, and low stream). The study was completed by 602 university students. Results: The average daily fluid intake was >2 L/day for both genders. The gender difference in fluid intake was significant (p < 0.05). Male students were more than consumption of caffeinated drinks and alcohol. The urinary symptom profile score was stress urinary incontinence, overactive bladder and low stream 0.16, 2.41, 0.28 respectively. The male students compared to female students difference in stress urinary incontinence and low stream was found to be statistically significant (p < 0.05). Conclusion: In conclusion, fluid intake habits and urinary symptoms differ between genders in the healthy young population.
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Lackner, Thomas E. "Advances in Managing Overactive Bladder." Journal of Pharmacy Practice 13, no. 4 (August 2000): 277–89. http://dx.doi.org/10.1177/089719000001300405.
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Overactive bladder (OB), formerly known as urge incontinence, is the most common type of urinary incontinence. The appropnate management of OB is more important than ever since the number of persons with OB is expected to increase with the growing elderly population, the group at highest risk for OB. At the same time new drugs are available that are generally as effective and better tolerated than the current "gold standard" drug therapy. To facilitate the selection of optimum pharmacotherapy for OB, the important distinguishing properties of the traditional and new drug therapies for OB will be reviewed.
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Navarro, Junior J. Araiza J. Araiza, Raúl D. Lara Sánchez, Oyuki A. Morales Uscanga, María I. Tolentino Sosa, Fernando López Reyes, and Jorge A. Barbabosa Vilchis. "Refractory hyperactive bladder treated with sacral neuromodulator: case report and literature review." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 7 (June 27, 2018): 2937. http://dx.doi.org/10.18203/2320-1770.ijrcog20182910.
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The overactive bladder syndrome is a chronic medical condition that affects the quality of life of patients whether men or women, has a prevalence of 16.5%, however, it is known to increase with age, affecting up to 25% of women older than 65 years and up to 80% in the elderly. More than 90% of cases have no apparent cause. The OAB (Overactive Bladder) It is a condition with characteristic symptoms of urinary urgency, usually accompanied by frequency and nocturia, with or without urge incontinence, in the absence of urinary tract infection or other obvious pathology. The different therapeutic steps are not always sufficient to restore the quality of life.
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Djermanov, Marina, and Dragana Zivkovic. "Biofeedback in the treatment of lower urinary tract symptoms in children." Medical review 71, no. 5-6 (2018): 167–70. http://dx.doi.org/10.2298/mpns1806167d:.
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Introduction. Bladder and bowel dysfunction describes a large spectrum of lower urinary tract symptoms along with fecal elimination issues. The aim of the study was to analyze the effects of biofeedback treatment in children with lower urinary tract symptoms. Material and Methods. A prospective study analyzed the effects of biofeedback treatment conducted in children with lower urinary tract symptoms. Questionnaires and voiding diaries were collected prior to the treatment. The patients were followed for two weeks on daily basis. After the completion of the treatment, the data from voiding diaries and questionnaires were analyzed. Results. A total of 18 children were referred for biofeedback treatment. Seven patients had an overactive bladder. seven had isolated dysfunctional voiding, and in the third group three had difficulties starting to void and one had daily incontinence with dysfunctional voiding. A total of 14 patients presented with improvement of symptoms. The analyzed data showed no measurable improvement in one patient, even though he reported a personal feeling of improvement. Three patients without positive effects of the therapy were immature and non-cooperative. In six out of seven patients with overactive bladder with urine leakage, the symptom disappeared by the end of the treatment. Conclusion. Biofeedback is a very useful tool in the treatment of lower urinary tract symptoms in pediatric population. Although the main indication for initiating this therapy is dysfunctional voiding, the study showed an improvement of symptoms in patients with overactive bladder as well.
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Kotowicz, Zuzanna, Jakub Pabiś, and Piotr Podgórski. "An examination of Overactive Bladder Syndrome: present comprehension, methods of treatment, and innovative approaches." Journal of Education, Health and Sport 64 (March 22, 2024): 106–17. http://dx.doi.org/10.12775/jehs.2024.64.007.
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Introduction
Overactive bladder syndrome poses a major challenge to healthcare, as an accurate estimate of its prevalence proves elusive due to patients' reluctance to disclose the embarrassing symptoms that accompany the disorder. Symptoms such as frequent urination, nocturia and incontinence are not only distressing but also significantly impair patients' quality of life. Effective diagnosis and treatment require the identification of associated risk factors, and behavioural therapy serves as the basis for implementing lifestyle modifications. This comprehensive study delves into the managing of overactive bladder syndrome, shedding light on recent advances in diagnosis and treatment. In particular, it looks at the integration of minimally invasive techniques and new medications that promise to not only alleviate symptoms, but also significantly improve patients' overall quality of life.
Aim of the study
This review aims to identify risk factors, symptoms, methods of diagnosis of overactive bladder syndrome and solutions in its treatment process. The main aim is to present treatment methods with the latest developments.
Material and method
This article presents the current state of knowledge about overactive bladder syndrome in various scientific articles. Publications describing overactive bladder syndrome, its symptoms, impact on life comfort and treatment options, including recent reports in the field, were reviewed using the PubMed platform. The search included the keywords ‘overactive bladder’, ‘urgency urinary incontinence’, ‘anticholinergics’, ‘mirabegron’, ‘nocturia’.
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Grus, Cyril. "Monitoring the relationship between overactive bladder and mobility disorders in women with multiple sclerosis." Česká gynekologie 88, no. 5 (October 30, 2023): 353–58. http://dx.doi.org/10.48095/cccg2023353.
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Summary: Background: Currently, there is a lack of studies monitoring the relationship between lower urinary tract symptoms and mobility disorders in women with multiple sclerosis. The aim of this study was to monitor the relationship between overactive bladder and mobility impairments in women with multiple sclerosis. Methods: A number of 106 female patients with multiple sclerosis (MS) with relapsing-remitting (RR) form, disability stage: EDSS ≤ 6.5, from the specialized outpatient clinic of the Department of Neurology, Faculty of Medicine, University of Medical Sciences in Košice. Urinary leakage symptoms were assessed by the modified International Consultation on Incontinence Questionnaire (ICIQ UI-SF), and overactive bladder symptoms were assessed by the Short Overactive Bladder Symptoms Questionnaire (OAB-q). The Multiple Sclerosis Impact Scale (MSIS-29) and the Rivermead Mobility Index (RMI) were used. Conclusion: In MS patients, we found the following correlations: a significant positive mean correlation between the severity of OAB and UI symptoms and physical attributes. We found a significant positive moderate correlation between severity of OAB and UI symptoms and psychological attributes. We found a negative significant moderate correlation between OAB and UI symptom severity and mobility. It was confirmed that the more severe the symptoms of UI and OAB, the greater the difficulty of mobility in performing physical activities, and thus the negative impact of SM disease on patients' psychological health increases. Key words: multiple sclerosis – overactive bladder – mobility
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Shim, Jisung, and Mi Mi Oh. "Updates of Overactive Bladder in Pediatrics." International Neurourology Journal 27, no. 1 (March 31, 2023): 3–14. http://dx.doi.org/10.5213/inj.2244228.114.
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Overactive bladder (OAB) is clinically defined as urinary urgency with or without urinary incontinence. It is associated with daytime frequency or constipation and has a prevalence of approximately 5%–12% among 5- to 10-year-olds. The appropriate functional exchange between the pontine micturition center, periaqueductal gray matter, and prefrontal cortex is important for proper micturition control. Several studies on pediatric cases observed a link between OAB and neuropsychiatric problems, such as anxiety, depression, and attention deficit, and treatment of these comorbidities improved patient symptoms. In this review, we present the pathophysiology of OAB, its associated conditions, and aspects related to updates in OAB treatment, and we propose a step-by-step treatment approach following this sequence: behavioral therapy, medical treatment, and invasive treatment. Although anticholinergic drugs are the mainstay of OAB medical treatment, beta-3 agonists and alpha-blockers are now recommended as a result of significant advancements in pharmacologic treatment in the last 10 years. Electrical stimulation techniques and botulinum toxin are also effective and can be used, especially in conventional treatment-refractory cases.
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Pradhan, Tarun, Baburam Dixit Thapa, Pritha Basnet, Surya Prasad Rimal, Tulasha Basnet, and Mohan Chandra Regmi. "Evaluation of Lower Urinary Tract Symptoms (LUTS): Severity Score and Symptom Association." Birat Journal of Health Sciences 4, no. 2 (September 4, 2019): 684–87. http://dx.doi.org/10.3126/bjhs.v4i2.25435.
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Introduction: Lower urinary tract symptoms (LUTS) is a group of symptoms relating to stages of micturation such as storage symptoms, voiding dysfunction and post micturation dysfunction. Overactive bladder symptom score (OABSS) is a questionnaires with scores which helps in evaluating the severity of symptoms.
Objectives To find the incidence of women visiting with LUTS and to evaluate storage symptoms in LUTS (urgency, urge incontinence, frequency) using OABSS (overactive bladder symptom score) questionnaires.
Methodology This is a prospective study done from February 2016 to February 2017. Patients visiting Department of Obstetrics and Gynaecology with lower urinary tract symptoms (LUTS) were enrolled in the study after informed consent. Patients were assessed for types of LUTS and data were filled in the performa. If patients had urgency, urge incontinence, increased day time frequency, then the patients were explained and asked overactive bladder symptom score questionnaire (OABSS) and noted. Patients were then examined for pelvic floor dysfunction and neurological abnormalities for identifying association with the symptoms. Statistical analysis was done using SPSS 11.5.
Results Fifty-seven patients were enrolled with lower urinary tract symptoms (LUTS) during study period. Forty-six patients had overactive bladder symptoms (OABS). LUTS were found in age ranging from 21 to 80 years. Majority of patients visiting out-patient department with LUTS were found to have urgency, urge incontinence, increased day time frequency, nocturia. Patients with urgency and urge incontinence showed significant correlation with increasing likert score of OABSS (p<0.05). But the increased day time frequency did not show any correlation with increasing score. The score showed significant correlation with combination of symptoms (urgency, urge incontinence and increased frequency) than patients presenting with single symptom.
Conclusion Diagnosis of LUTS with valid assessment tools and treatment benefits patients with chronic urinary symptoms and also helps clinicians to further re-assess the treatment.
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Sacco, Emilio. "Physiopathology of Overactive Bladder Syndrome." Urologia Journal 79, no. 1 (January 2012): 24–35. http://dx.doi.org/10.5301/ru.2012.8972.
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The pathophysiology of OAB is complex, multifactorial and still largely unknown. Several pathophysiological mechanisms have been highlighted that may play a different role in different patient groups. There are now experimental evidences that support both the myogenic and neurogenic hypothesis, but in recent years the “integrative” hypothesis has been gaining more and more acceptance, where a disruption in the multiple interactions between different cell types (neurons, urothelium, interstitial cells, myocytes) and network functions represent a central element of lower urinary tract dysfunctions. Of utmost importance, a disorder in the urothelial sensory function and in the urothelial/suburothelial non-neural cholinergic system, favored by age and comorbidities, appears to be crucial for the development of the OAB. Neuroplastic and detrusor changes in OAB are broadly similar to those observed in bladders exposed to outlet obstruction, neuropathies, inflammation or aging, and may be driven by a common urothelial dysfunction. Several signaling substances and their receptors were found to be involved in central pathways of bidirectional communication between the different cell types in the bladder, and were shown to be modified in several animal models of OAB as well as in human models, indicating new potential therapeutic targets.
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Cruz, Alejandro Gutierrez, Mafalda S. L. Aresta Branco, Brian A. Perrino, Kenton M. Sanders, and Violeta N. Mutafova-Yambolieva. "Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner." Metabolites 13, no. 1 (December 24, 2022): 30. http://dx.doi.org/10.3390/metabo13010030.
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Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urine of patients with overactive bladder, interstitial cystitis or bladder pain syndrome. Altered urinary ATP might also be associated with voiding dysfunctions linked to disease states associated with metabolic syndrome. Extracellular ATP levels are determined by ATP release and ATP hydrolysis by membrane-bound and soluble nucleotidases (s-NTDs). It is currently unknown whether s-NTDs regulate urinary ATP. Using etheno-ATP substrate and HPLC-FLD detection techniques, we found that s-NTDs are released in the lumen of ex vivo mouse detrusor-free bladders. Capillary immunoelectrophoresis by ProteinSimple Wes determined that intraluminal solutions (ILS) collected at the end of filling contain ENTPD3 > ENPP1 > ENPP3 ≥ ENTPD2 = NT5E = ALPL/TNAP. Activation of adenylyl cyclase with forskolin increased luminal s-NTDs release whereas the AC inhibitor SQ22536 had no effect. In contrast, forskolin reduced and SQ22536 increased s-NTDs release in the lamina propria. Adenosine enhanced s-NTDs release and accelerated ATP hydrolysis in ILS and lamina propria. Therefore, there is a regulated release of s-NTDs in the bladder lumen during filling. Aberrant release or functions of urothelial s-NTDs might cause elevated urinary ATP in conditions with abnormal bladder excitability.
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Kirsavoglu, Betul, Ozan Odabasi, and Ibrahim Erkut Avci. "Solifenacin-induced acute psychosis: a case report." General Psychiatry 34, no. 5 (October 2021): e100586. http://dx.doi.org/10.1136/gpsych-2021-100586.
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Solifenacin is a muscarinic receptor antagonist that has been used to treat overactive bladder since 2004. It has a great affinity for the detrusor M3 receptor, which must be stimulated for bladder muscle contraction, and demonstrates the most selective profile to the bladder of the muscarinic receptor subtypes. It is thought that urinary antimuscarinic agents, due to their passage to the central nervous system and lipophilic properties, may cause central nervous system symptoms in some rare cases. A case report of a 42-year-old male patient who had an acute psychotic attack as a result of solifenacin treatment for overactive bladder is presented in this article.
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Thiagarajan, Senthil Kumar, Vikrant Mahajan, Jambunathan Saravanan, Harsha Kurabalakota, Meyyappan RM, Srinavasan T, Madhu Gowda, and Gokul Nachiketh. "A Comparative Study of Efficacy and Tolerability of Solifenacin and Mirabegron, for the Treatment of Overactive Bladder - A Randomized Prospective Control Study." Journal of Evolution of Medical and Dental Sciences 10, no. 42 (October 18, 2021): 3654–58. http://dx.doi.org/10.14260/jemds/2021/741.
Full textAbstract:
BACKGROUND Overactive bladder (OAB) is a chronic, age-related disorder seen in 11 % of patients. Symptoms consist of urinary urgency, with or without urinary incontinence, usually with frequency or nocturia. The objective of the present study was to compare the efficacy and side effects of mirabegron and solifenacin as primary therapies in patients with overactive bladder. METHODS This was a prospective interventional study. 100 patients aged between 18 years and 50 years with overactive bladder were included and were assigned into two treatment groups of solifenacin 5 mg or mirabegron 50 mg. They were asked to record the number of micturitions in a day, urgency episodes, incontinence episodes and volume of each micturition. All patients went through a basic workup with blood sugar to rule out diabetes, USG KUB to rule out bladder stones, and urine culture and sensitivity to rule out urinary tract infection (UTI). RESULTS 100 patients with OAB were selected for the study and divided into equal groups, 50 receiving 5 mg solifenacin and 50 receiving 50 mg mirabegron. Both groups increased the mean micturition volume but mirabegron was more effective in increasing the mean micturition in patients with OAB. Both drugs were well tolerated. There was a significant increase in mean micturition volume in mirabegron 50 mg group (by 20.7 + / - 2.2 mL), P < 0.001 whereas in solifenacin group micturition volume was increased to 22.2 + / -0.97 ml). The most common side-effect in the mirabegron group was hypertension and the most common side effect in the solifenacin group was dry mouth. CONCLUSIONS Both mirabegron and solifenacin were effective in controlling the frequency of micturition, decreasing urgency and incontinence episodes and increasing the mean volume of micturition. Mirabegron was more effective than solifenacin in controlling urgency and incontinence episodes and increasing the mean volume of micturition. KEY WORDS Overactive Bladder (OAB), Micturition, Mirabegron, Solifenacin.
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Mingin, Gerald C., Thomas J. Heppner, Nathan R. Tykocki, Cuixia Shi Erickson, Margaret A. Vizzard, and Mark T. Nelson. "Social stress in mice induces urinary bladder overactivity and increases TRPV1 channel-dependent afferent nerve activity." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 309, no. 6 (September 15, 2015): R629—R638. http://dx.doi.org/10.1152/ajpregu.00013.2015.
Full textAbstract:
Social stress has been implicated as a cause of urinary bladder hypertrophy and dysfunction in humans. Using a murine model of social stress, we and others have shown that social stress leads to bladder overactivity. Here, we show that social stress leads to bladder overactivity, increased bladder compliance, and increased afferent nerve activity. In the social stress paradigm, 6-wk-old male C57BL/6 mice were exposed for a total of 2 wk, via barrier cage, to a C57BL/6 retired breeder aggressor mouse. We performed conscious cystometry with and without intravesical infusion of the TRPV1 inhibitor capsazepine, and measured pressure-volume relationships and afferent nerve activity during bladder filling using an ex vivo bladder model. Stress leads to a decrease in intermicturition interval and void volume in vivo, which was restored by capsazepine. Ex vivo studies demonstrated that at low pressures, bladder compliance and afferent activity were elevated in stressed bladders compared with unstressed bladders. Capsazepine did not significantly change afferent activity in unstressed mice, but significantly decreased afferent activity at all pressures in stressed bladders. Immunohistochemistry revealed that TRPV1 colocalizes with CGRP to stain nerve fibers in unstressed bladders. Colocalization significantly increased along the same nerve fibers in the stressed bladders. Our results support the concept that social stress induces TRPV1-dependent afferent nerve activity, ultimately leading to the development of overactive bladder symptoms.