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Journal articles on the topic 'Overload model'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Tsay, Jaime, Zheiwei Yang, F. Patrick Ross, et al. "Bone loss caused by iron overload in a murine model: importance of oxidative stress." Blood 116, no. 14 (2010): 2582–89. http://dx.doi.org/10.1182/blood-2009-12-260083.

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AbstractOsteoporosis is a frequent problem in disorders characterized by iron overload, such as the thalassemias and hereditary hemochromatosis. The exact role of iron in the development of osteoporosis in these disorders is not established. To define the effect of iron excess in bone, we generated an iron-overloaded mouse by injecting iron dextran at 2 doses into C57/BL6 mice for 2 months. Compared with the placebo group, iron-overloaded mice exhibited dose-dependent increased tissue iron content, changes in bone composition, and trabecular and cortical thinning of bone accompanied by increas

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2

Stroebe, Margaret, and Henk Schut. "Overload." OMEGA - Journal of Death and Dying 74, no. 1 (2016): 96–109. http://dx.doi.org/10.1177/0030222816666540.

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The Dual Process Model of Coping with Bereavement (DPM) was put forward as a framework to help understand reactions to the death of a loved person. Since its inception, there have been various developments and further specifications regarding the model’s parameters. A number of researchers have assessed the model’s contribution and put some of its parameters to empirical test. It has also been applied in clinical practice. Despite generally positive assessment among both scientific and applied communities, we recently discovered what we consider to be a major shortcoming. The concept of overlo

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3

Kidd, James M., Kamilia Abdelraouf, and David P. Nicolau. "1553. Human-Simulated Pharmacokinetic Profiles of Cefiderocol and Meropenem Are Conserved in Murine Models of Thigh Infection With or Without Iron Overload." Open Forum Infectious Diseases 6, Supplement_2 (2019): S567. http://dx.doi.org/10.1093/ofid/ofz360.1417.

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Abstract Background A translational murine model of thigh infection with comorbid iron overload was previously developed to study the efficacy of iron-dependent siderophore-antibiotic conjugates under conditions where the hypoferremic response of innate immunity may be compromised. Given the potential for functional organ damage from excessive tissue iron, which could alter the pharmacokinetic (PK) profiles of antibiotics being compared for efficacy using this model, the effects of iron overload on a siderophore-β-lactam conjugate, cefiderocol (CFDC), and a non-siderophore β-lactam, meropenem

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4

Huang, Jiawei, Qingchun Meng, Zhixin Zhan, Weiping Hu, and Fei Shen. "Damage mechanics-based approach to studying effects of overload on fatigue life of notched specimens." International Journal of Damage Mechanics 28, no. 4 (2018): 538–65. http://dx.doi.org/10.1177/1056789518775173.

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A continuum damage mechanics-based method is adopted to predict the fatigue life of notched specimens subjected to constant amplitude cyclic loading while containing single or multiple overloads. The residual stress and plastic damage induced by an overload are considered to be the main factors affecting the fatigue life of a specimen. The residual stress and plastic strain fields of a notched specimen are calculated using the elastic–plastic finite element method. The mean stress of the following cyclic loading is then varied by superimposing the residual stress. Meanwhile, the plastic damage

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Rushton, Philip A., Farid Taheri, and David C. Stredulinsky. "Fatigue Response and Characterization of 350WT Steel Under Semi-Random Loading." Journal of Pressure Vessel Technology 129, no. 3 (2006): 525–34. http://dx.doi.org/10.1115/1.2748835.

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Novel data obtained through experimental investigation into the fatigue response of 350WT steel, subjected to semi-random loading, comprised of various combinations of intermittent tensile overloads and compressive underloads are presented. An effective model for predicting the fatigue response is also introduced. For that, the capabilities of some of the currently available models are investigated and then an exponential delay model, being capable of accounting for the effects of not only overload ratio, but also stress ratio and overload/underload ratio is introduced. Since most variable amp

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6

Zou, Xiao Li, and Jian Hui Yang. "Simulation of Fatigue Crack Growth Under Random Overloads with Retardation." Key Engineering Materials 324-325 (November 2006): 923–26. http://dx.doi.org/10.4028/www.scientific.net/kem.324-325.923.

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In order to study the behavior of fatigue crack propagation under random overloads, a Monte Carlo simulation scheme is proposed. Overloads of Poisson flow with uniform distribution on base-line constant-amplitude cyclic loads are considered. The retardation effect of overload is taken into account using crack closure model and the crack opening stress level is assumed to vary linearly in the yield zone produced by the overload. The fatigue crack growth curve from initial crack size till fatigue failure is simulated step by step. Through the large number of the simulated samples, the average fa

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7

Pasipoularides, Ares, Ming Shu, Ashish Shah, Scott Silvestry, and Donald D. Glower. "Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia." American Journal of Physiology-Heart and Circulatory Physiology 283, no. 5 (2002): H2140—H2150. http://dx.doi.org/10.1152/ajpheart.00462.2002.

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By limiting filling, abnormalities of right ventricular (RV) diastolic function may impair systolic function and affect adaptation to disease. To quantify diastolic RV pressure-volume relations and myocardial compliance (MC), a new sigmoidal model was developed. RV micromanometric and sonomicrometric data in alert dogs at control ( n = 16) and under surgically induced subacute (2–5 wk) RV pressure overload ( n = 6), volume overload ( n = 7), and ischemia ( n = 6) were analyzed. The conventional exponential model detected no changes from control in the passive filling pressure-volume (Ppf-V) re

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8

Alagna, Sheryle W. "An Overload(ed) Model of Stress Effects." Contemporary Psychology: A Journal of Reviews 30, no. 6 (1985): 499–500. http://dx.doi.org/10.1037/023876.

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9

Goel, H. S., and Satish Chand. "A Fatigue Crack Growth Model for Single Overload Tests." Journal of Engineering Materials and Technology 116, no. 2 (1994): 168–72. http://dx.doi.org/10.1115/1.2904268.

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Crack growth rate experiments are conducted by applying an intermediate single overload cycle in constant amplitude load (CAL) tests. For a particular overload ratio, three to four tests are conducted by applying the overload cycle at different crack lengths. The loads are selected in such a way that for a given overload ratio, the size of the overload and CAL monotonic plastic zones are the same at each crack length. A functional form for the crack growth during the retardation was developed that accurately describes all the tests. For comparison, the corresponding CA-load tests are also cond

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10

Yoshihara, Fumiki, Toshio Nishikimi, Takeshi Horio, et al. "Ventricular adrenomedullin concentration is a sensitive biochemical marker for volume and pressure overload in rats." American Journal of Physiology-Heart and Circulatory Physiology 278, no. 2 (2000): H633—H642. http://dx.doi.org/10.1152/ajpheart.2000.278.2.h633.

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This study was designed to investigate the pathophysiological significance of adrenomedullin (AM) concentration in volume- and pressure-overloaded cardiac hypertrophy. We measured ventricular AM concentrations and compared them with changes of α-actin and myosin heavy chain (MHC) mRNA isoforms after the creation of an aortocaval (AC) shunt as a volume-overload model or the injection of monocrotaline (MCT) as a pressure-overload model, respectively. The left ventricular AM levels after the creation of AC shunt and the right ventricular AM levels after the injection of MCT were significantly inc

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11

Anton, IVANOVICI, and PANAIT Marius Alexandru. "Overload prevention in model supports for wind tunnel model testing." INCAS BULLETIN 7, no. 3 (2015): 173–80. http://dx.doi.org/10.13111/2066-8201.2015.7.3.16.

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12

Harper, J., E. Harper, and J. W. Covell. "Collagen characterization in volume-overload- and pressure-overload-induced cardiac hypertrophy in minipigs." American Journal of Physiology-Heart and Circulatory Physiology 265, no. 2 (1993): H434—H438. http://dx.doi.org/10.1152/ajpheart.1993.265.2.h434.

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Previous studies in several different species have shown reduced extractability of collagens in some types of cardiac hypertrophy (volume overload) but not others (pressure overload). The objective of the present study was to examine collagen proteins from the same species (minipigs) with both pressure-overload- and volume-overload-induced cardiac hypertrophy. Hypertrophy was induced by two methods: thoracic banding of the aorta to create pressure overload and arteriovenous shunt to cause volume overload in a porcine model. Collagen types I, III, IV, and V were isolated by pepsin digestion fro

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13

Kłysz, Sylwester, and Paweł Szabracki. "Methodical Approach to the Analysis of Experimental Data Associated with the Fatigue Cracks Propagation Under Overload Conditions." Research Works of Air Force Institute of Technology 25, no. 1 (2009): 171–83. http://dx.doi.org/10.2478/v10041-009-0015-9.

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Methodical Approach to the Analysis of Experimental Data Associated with the Fatigue Cracks Propagation Under Overload Conditions The paper presents an analysis how overloads affect of fatigue cracks propagation rate where the analysis is carried out with use of the retardation model. The completed analysis covered the results of experimental examination of RCT-type samples made of the WT3-1 titanium alloy and was intended to determine interrelationships between individual parameters of the applied model. Comparison between theoretical calculations and experimental data was carried out for two

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14

Marino, T. A., R. L. Kent, C. E. Uboh, E. Fernandez, E. W. Thompson, and G. Cooper. "Structural analysis of pressure versus volume overload hypertrophy of cat right ventricle." American Journal of Physiology-Heart and Circulatory Physiology 249, no. 2 (1985): H371—H379. http://dx.doi.org/10.1152/ajpheart.1985.249.2.h371.

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Pressure overload of cat right ventricle causes progressive abnormalities of in vitro contractile function at a time when in vivo contractile function is normal. In marked contrast, the same degree and duration of volume overload of cat right ventricle results in neither in vitro nor in vivo contractile dysfunction. The purpose of the present quantitative structural study was to determine whether there were any histological alterations in pressure-overloaded myocardium that might be causally related to the contractile dysfunction found only in this model. Four experimental groups of eight cats

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15

Bautista, Joaquín, and Jaime Cano. "Minimizing work overload in mixed-model assembly lines." International Journal of Production Economics 112, no. 1 (2008): 177–91. http://dx.doi.org/10.1016/j.ijpe.2006.08.019.

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16

Kaiser, Lana, John M. Davis, and Kenneth A. Schwartz. "Does the gerbil model mimic human iron overload?" Journal of Laboratory and Clinical Medicine 141, no. 6 (2003): 419–20. http://dx.doi.org/10.1016/s0022-2143(03)00038-6.

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17

Jackson, Thomas W., and Pourya Farzaneh. "Theory-based model of factors affecting information overload." International Journal of Information Management 32, no. 6 (2012): 523–32. http://dx.doi.org/10.1016/j.ijinfomgt.2012.04.006.

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18

Zhang, Yun Peng. "Research and Application of Importance Degree Evaluation Method of Complex Network Cascade Connection Node Based on Load Redistribution." Advanced Materials Research 998-999 (July 2014): 1174–77. http://dx.doi.org/10.4028/www.scientific.net/amr.998-999.1174.

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This paper presented a model with overload function for cascading failure. The main differences with respect to previous models are as follows: overload function is defined for each node, according to the value of overload function, one node has th ree states: success, overload, failure. After the load decreases, an overloaded node can be success again. The evolution of topology is replaced by the evolution of value of overload function during the process of cascading failure. It’s needless to delete the failure nodes and its edges, the load will avoid the failure nodes automat ically and the

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19

Kim, Kyung Su, Dong In Cho, Jae Wook Ahn, and Seung Bok Choi. "An Experimental Study on Fatigue Crack Propagation under Cyclic Loading with Multiple Overloads." Key Engineering Materials 297-300 (November 2005): 2495–500. http://dx.doi.org/10.4028/www.scientific.net/kem.297-300.2495.

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For many fatigue-critical parts of machines and structures, the load history under operating conditions generally involves variable amplitude loading rather than constant amplitude loading. An accurate prediction of fatigue crack propagation life under variable amplitude loading requires a thorough evaluation of the load interaction effects. In this study, fatigue tests under both constant and variable amplitude loading were carried out to investigate the overload effects on fatigue crack propagation of the notched specimens. Strain distributions around the crack tip before and after a tensile

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20

Willett, Thomas L., Rosalind S. Labow, and J. Michael Lee. "Mechanical overload decreases the thermal stability of collagen in an in vitro tensile overload tendon model." Journal of Orthopaedic Research 26, no. 12 (2008): 1605–10. http://dx.doi.org/10.1002/jor.20672.

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21

Jiang, Shan, Wei Zhang, Xiaoyang Li, and Fuqiang Sun. "An Analytical Model for Fatigue Crack Propagation Prediction with Overload Effect." Mathematical Problems in Engineering 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/713678.

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In this paper a theoretical model was developed to predict the fatigue crack growth behavior under the constant amplitude loading with single overload. In the proposed model, crack growth retardation was accounted for by using crack closure and plastic zone. The virtual crack annealing model modified by Bauschinger effect was used to calculate the crack closure level in the outside of retardation effect region. And the Dugdale plastic zone model was employed to estimate the size of retardation effect region. A sophisticated equation was developed to calculate the crack closure variation during

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22

Szada-Borzyszkowski, Wiesław, and Monika Szada-Borzyszkowska. "Influence of selected road parameters on overloads during a vehicle collision with a fixed obstacle." AUTOBUSY – Technika, Eksploatacja, Systemy Transportowe 19, no. 9 (2018): 71–74. http://dx.doi.org/10.24136/atest.2018.286.

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The article presents general characteristics of road accidents. The influence of overload on the human body during impact was discussed. Authors created a mathematical model describing the impact of selected road parameters on overloads during a car collision with a fixed obstacle.

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23

Lin, Yi-Hsin, Suyu Gu, Wei-Sheng Wu, Rujun Wang, and Fan Wu. "Analysis and Prediction of Overloaded Extra-Heavy Vehicles for Highway Safety Using Machine Learning." Mobile Information Systems 2020 (December 30, 2020): 1–20. http://dx.doi.org/10.1155/2020/6667897.

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Along with the prosperity and rapid development of the national economy, the transportation industry has rapidly developed in China. However, overloaded vehicles have been causing frequent traffic accidents. Thus, to alleviate or resolve the corresponding problems associated with highway engineering safety and the market economy, an improved technique for overload management is urgently required. In this study, to analyze the overload data on expressways and highways in China, we developed a machine learning model by comparing the performances of cluster analysis, backpropagation neural networ

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24

Gao, Zhi, Roy S. Colby, Thomas G. Habetler, and Ronald G. Harley. "A Model Reduction Perspective on Thermal Models for Induction Machine Overload Relays." IEEE Transactions on Industrial Electronics 55, no. 10 (2008): 3525–34. http://dx.doi.org/10.1109/tie.2008.926772.

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25

Molina, Ezequiel J., Dipin Gupta, Jon Palma, et al. "Novel Experimental Model of Pressure Overload Hypertrophy in Rats." Journal of Surgical Research 153, no. 2 (2009): 287–94. http://dx.doi.org/10.1016/j.jss.2008.03.043.

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26

Ransom, Daniel L., and Randy Hamilton. "Extending Motor Life With Updated Thermal Model Overload Protection." IEEE Transactions on Industry Applications 49, no. 6 (2013): 2471–77. http://dx.doi.org/10.1109/tia.2013.2265375.

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27

Honda, M., Y. Hori, Y. Shionoya, K. Yamamoto, F. Kojima, and T. Nakamura. "Fluid overload deteriorate chylothorax: evaluation in a canine model." Diseases of the Esophagus 25, no. 3 (2011): 269–72. http://dx.doi.org/10.1111/j.1442-2050.2011.01237.x.

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28

Ballew, Mary A., David Kriebel, and Thomas J. Smith. "Epidemiologic Application of a Dosimetric Model of Dust Overload." American Journal of Epidemiology 141, no. 7 (1995): 690–96. http://dx.doi.org/10.1093/oxfordjournals.aje.a117486.

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29

LAUD, ROBERT L., and DONALD H. SCHEPERS. "Beyond Transparency: Information Overload and a Model for Intelligibility." Business and Society Review 114, no. 3 (2009): 365–91. http://dx.doi.org/10.1111/j.1467-8594.2009.00347.x.

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30

MATANACHAI, SITTICHAI, and CANDACE ARAI YANO. "Balancing mixed-model assembly lines to reduce work overload." IIE Transactions 33, no. 1 (2001): 29–42. http://dx.doi.org/10.1080/07408170108936804.

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31

Cumbermack, Kristopher M., Jun Cheng, Yibing Nong, et al. "A Juvenile Murine Heart Failure Model of Pressure Overload." Pediatric Cardiology 32, no. 2 (2010): 145–53. http://dx.doi.org/10.1007/s00246-010-9833-3.

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32

Brandão, A. F. "A model for substation reliability analysis including overload effects." International Journal of Electrical Power & Energy Systems 9, no. 4 (1987): 194–205. http://dx.doi.org/10.1016/0142-0615(87)90001-9.

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33

Sheu, B. C., P. S. Song, and S. Hwang. "Shaping exponent in wheeler model under a single overload." Engineering Fracture Mechanics 51, no. 1 (1995): 135–43. http://dx.doi.org/10.1016/0013-7944(94)00250-l.

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34

Nedopetalski, Felipe, and Joslaine Cristina Jeske de Freitas. "Overload Control in a Token Player for a Fuzzy Workflow Management System." Revista de Informática Teórica e Aplicada 28, no. 1 (2021): 11–21. http://dx.doi.org/10.22456/2175-2745.105893.

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The underlying proposal of this work is to control overload of a Token Player in a Fuzzy Workflow Management System. In order to accomplish this, possibility theory is used to measure how much the Token Player can be overloaded. The model used in this work is built using Colored Petri net and the simulation is made using CPN Tools. Finally, is possible to control overload of the Token Player in a Fuzzy Workflow Management System, nevertheless more time is spent to achieve the end of activities.

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35

Molina-Sánchez, Pedro, and Amaia Lujambio. "Iron overload and liver cancer." Journal of Experimental Medicine 216, no. 4 (2019): 723–24. http://dx.doi.org/10.1084/jem.20190257.

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In this issue of JEM, Muto et al. (https://doi.org/10.1084/jem.20180900) generate a novel mouse model of liver cancer induced by iron overload by deleting the iron-sensing ubiquitin ligase FBXL5 specifically in hepatocytes and exposure to a chemical carcinogen.

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Chai, Xiao, Deguan Li, Mingfeng Zhao, et al. "ROS-Mediated Iron Overload Injures The Hematopoiesis Of Bone Marrow By Damaging Hematopoietic Stem/Progenitor Cells In Mice." Blood 122, no. 21 (2013): 962. http://dx.doi.org/10.1182/blood.v122.21.962.962.

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Abstract A substantial portion of patients with inherited blood disorders such as beta thalassemia, or bone marrow failure syndromes such as aplastic anemia(AA), myelodysplastic syndromes(MDS) require frequent transfusions of red blood cells. Frequent blood transfusions may lead to the excess of plasma non-transferrin -bound iron(NTBI) and iron overload occurs, which will significantly injure bone marrow (BM) function as well as induce organ dysfunctions such as liver cirrhosis, diabetes and cardiac diseases. However, the exact mechanism behind this effect remains elusive and ideal treatment n

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37

Chaillou, Thomas, Nathalie Koulmann, Nadine Simler, et al. "Hypoxia transiently affects skeletal muscle hypertrophy in a functional overload model." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 302, no. 5 (2012): R643—R654. http://dx.doi.org/10.1152/ajpregu.00262.2011.

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Hypoxia induces a loss of skeletal muscle mass, but the signaling pathways and molecular mechanisms involved remain poorly understood. We hypothesized that hypoxia could impair skeletal muscle hypertrophy induced by functional overload (Ov). To test this hypothesis, plantaris muscles were overloaded during 5, 12, and 56 days in female rats exposed to hypobaric hypoxia (5,500 m), and then, we examined the responses of specific signaling pathways involved in protein synthesis (Akt/mTOR) and breakdown (atrogenes). Hypoxia minimized the Ov-induced hypertrophy at days 5 and 12 but did not affect th

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38

Chery, Josue, Shan Huang, Lianghui Gong, et al. "Human Neonatal Thymus Mesenchymal Stem/Stromal Cells and Chronic Right Ventricle Pressure Overload." Bioengineering 6, no. 1 (2019): 15. http://dx.doi.org/10.3390/bioengineering6010015.

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Right ventricle (RV) failure secondary to pressure overload is associated with a loss of myocardial capillary density and an increase in oxidative stress. We have previously found that human neonatal thymus mesenchymal stem cells (ntMSCs) promote neovascularization, but the ability of ntMSCs to express the antioxidant extracellular superoxide dismutase (SOD3) is unknown. We hypothesized that ntMSCs express and secrete SOD3 as well as improve survival in the setting of chronic pressure overload. To evaluate this hypothesis, we compared SOD3 expression in ntMSCs to donor-matched bone-derived MSC

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39

Lattrich, Kai-Kristina, and Marion Büttgen. "Project leaders’ control resources and role overload as predictors of project success: developing the job demands–resources model." Business Research 13, no. 2 (2020): 767–88. http://dx.doi.org/10.1007/s40685-020-00115-z.

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Abstract Drawing on the job demands–resources model (JD–R model), this article introduces information control and team control as project leader-specific job resources, as well as role overload as a demand, and then examines their influences on project experience appraisals and project success. With a sample of 185 project leaders, this study reveals that all three factors drive project success and project leader well-being. The moderating effects of role overload on the relationships between team control and negative experience and between team control and goal attainment are particularly rem

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Bartnikas, Thomas Benedict, Sheryl Wildt, Amy Wineinger, et al. "A Novel Rat Model of Hereditary Hemochromatosis Due to a Mutation in Transferrin Receptor 2." Blood 120, no. 21 (2012): 612. http://dx.doi.org/10.1182/blood.v120.21.612.612.

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Abstract Abstract 612 Sporadic iron overload has been reported previously in rats but the underlying cause has not been ascertained. In this study, phenotypic analysis of a subpopulation of Wistar rats designated Hsd:HHCL revealed a low incidence of histologically detected liver iron overload. One rat out of 132 screened animals exhibited liver iron accumulation in a predominantly periportal, hepatocellular distribution; this male rat expressed low RNA levels of the iron regulatory hormone hepcidin and low protein levels of transferrin receptor 2, a membrane protein essential for hepcidin expr

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Wu, Dijiong, Xiaowen Wen, Baodong Ye, et al. "Establishment of a Mouse Model of Aplastic Anemia Complicated By Iron Overload." Blood 126, no. 23 (2015): 4555. http://dx.doi.org/10.1182/blood.v126.23.4555.4555.

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Abstract Aplastic anemia (AA) is a common hematologic disease characterized by hematopoietic failure of the bone marrow and pancytopenia of the peripheral blood. Some patients with AA suffer from transfusion-induced iron overload secondary to long-term blood transfusions due to moderate and severe anemia. Topics related to iron overload and chelation therapy have recently become important in hematologic diseases, especially in hematopoietic failure. However, no animal model of AA complicated by iron overload has been developed, which affects drug research and development. The purpose of our st

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42

Yin, Pengzhen, Carol X. J. Ou, Robert M. Davison, and Jie Wu. "Coping with mobile technology overload in the workplace." Internet Research 28, no. 5 (2018): 1189–212. http://dx.doi.org/10.1108/intr-01-2017-0016.

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Purpose The overload effects associated with the use of mobile information and communication technologies (MICTs) in the workplace have become increasingly prevalent. The purpose of this paper is to examine the overload effects of using MICTs at work on employees’ job satisfaction, and explore the corresponding coping strategies. Design/methodology/approach The study is grounded on the cognitive load theory and the coping model of user adaptation. The overload antecedents and coping strategies are integrated into one model. Theoretical hypotheses are tested with survey data collected from a sa

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Chen, Xiaolong, Guozhong Huang, Xuehong Gao, Shengnan Ou, Yatao Li, and Ibrahim M. Hezam. "BN-RA: A Hybrid Model for Risk Analysis of Overload-Induced Early Cable Fires." Applied Sciences 11, no. 19 (2021): 8922. http://dx.doi.org/10.3390/app11198922.

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Cable overload is one of the most critical contributors to early cable fires. This study proposes a hybrid Bayesian network (BN)-based fire risk analysis model, to investigate the evolution of overload-induced early cable fire risks. In particular, the fire risk transmission paths caused by cable overload are reported, considering the critical factors that likely lead to fires. A BN with a specific structure was considered using the fire risk transmission paths. Later, given the risk index system, a hybrid fire risk assessment model caused by cable overload was developed based on the entropy w

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Volani, Chiara, Giuseppe Paglia, Sigurdur Smarason, et al. "Metabolic Signature of Dietary Iron Overload in a Mouse Model." Cells 7, no. 12 (2018): 264. http://dx.doi.org/10.3390/cells7120264.

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Iron is an essential co-factor for several metabolic processes, including the Krebs cycle and mitochondrial oxidative phosphorylation. Therefore, maintaining an appropriate iron balance is essential to ensure sufficient energy production and to avoid excessive reactive oxygen species formation. Iron overload impairs mitochondrial fitness; however, little is known about the associated metabolic changes. Here we aimed to characterize the metabolic signature triggered by dietary iron overload over time in a mouse model, where mice received either a standard or a high-iron diet. Metabolic profilin

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45

Karabeg, Reuf, Fikret Veljovic, Avdo Voloder, et al. "A Mathematical Model of Achilles Tendon Overload During Jump Shot." Medical Archives 73, no. 4 (2019): 228. http://dx.doi.org/10.5455/medarh.2019.73.228-233.

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46

Tapia Moore, Ernesto. "Information Overload and the Internationalization Process Model: An Implementation Attempt." Journal of Business 9, no. 1 (2017): 119–42. http://dx.doi.org/10.21678/jb.2017.827.

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47

DESJARDINS, S., R. W. MUELLER, and M. J. CAUCHY. "A pressure overload model of congestive heart failure in rats." Cardiovascular Research 22, no. 10 (1988): 696–702. http://dx.doi.org/10.1093/cvr/22.10.696.

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Schwartz, Kenneth A., Jill Fisher, and E. Terence Adams. "Morphologic Investigations of the Guinea Pig Model of Iron Overload." Toxicologic Pathology 21, no. 3 (1993): 311–20. http://dx.doi.org/10.1177/019262339302100307.

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Norrdin, R. W., C. E. Kawcak, B. A. Capwell, and C. W. McIlwraith. "Subchondral Bone Failure in an Equine Model of Overload Arthrosis." Bone 22, no. 2 (1998): 133–39. http://dx.doi.org/10.1016/s8756-3282(97)00253-6.

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Yang, Tianen, Wei-Qiang Dong, Yuri A. Kuryshev, et al. "Bimodal cardiac dysfunction in an animal model of iron overload." Journal of Laboratory and Clinical Medicine 140, no. 4 (2002): 263–71. http://dx.doi.org/10.1067/mlc.2002.127725.

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