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1

Ginther, O. J., M. O. Gastal, E. L. Gastal, J. C. Jacob, and M. A. Beg. "Induction of haemorrhagic anovulatory follicles in mares." Reproduction, Fertility and Development 20, no. 8 (2008): 947. http://dx.doi.org/10.1071/rd08136.

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A follicular wave and luteolysis were induced in mares by ablation of follicles ≥6 mm and treatment with prostaglandin F2α (PGF) on Day 10 (where ovulation = Day 0). The incidence of haemorrhagic anovulatory follicles (HAFs) in the induced waves (20%) was greater (P < 0.007) than in preceding spontaneous waves (2%). Hormone and follicle dynamics were compared between induced follicular waves that ended in ovulations (ovulating group; n = 36) v. HAFs (HAF group; n = 9). The day of the first ovulation or the beginning of HAF formation at the end of an induced wave was designated as post-treatment Day 0. The mean 13-day interval from Day 10 (PGF and ablation) to the post-treatment ovulation was normalised into Days 10 to 16, followed by Day –6 to Day 0 relative to the post-treatment ovulation. Concentrations of LH were greater (P < 0.05) in the HAF group than in the ovulating group on Days 10, 11, 12, 14, –3 and –2. The HAF group had greater (P < 0.003) LH concentrations on Day 10 of the preceding oestrous cycle with spontaneous ovulatory waves. The diameter of the largest follicle was less (P < 0.05) in the HAF group on most days between Day 13 and Day –1 and this was attributable to later (P < 0.002) emergence of the future largest follicle at 6 mm in the HAF group (Day 12.4 ± 0.5) than in the ovulating group (Day 11.3 ± 0.1). The results indicate that the high incidence of HAFs after PGF and ablation was associated with later follicle emergence and immediate and continuing greater LH concentration after PGF treatment, apparently augmented by an inherently high pretreatment LH concentration.
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2

Kennedy, Janet L., and Eli Y. Adashi. "Ovulation Induction." Obstetrics and Gynecology Clinics of North America 14, no. 4 (December 1987): 831–64. http://dx.doi.org/10.1016/s0889-8545(21)00591-x.

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3

WOLF, LYNDA J. "Ovulation Induction." Clinical Obstetrics and Gynecology 43, no. 4 (December 2000): 902–15. http://dx.doi.org/10.1097/00003081-200012000-00020.

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4

Homburg, Roy. "Ovulation induction." Expert Opinion on Pharmacotherapy 4, no. 11 (November 2003): 1995–2004. http://dx.doi.org/10.1517/14656566.4.11.1995.

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5

Smith, Pamela M. "Ovulation Induction." Journal of Obstetric, Gynecologic & Neonatal Nursing 14 (November 1985): S37—S43. http://dx.doi.org/10.1111/j.1552-6909.1985.tb02798.x.

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6

Von Hofe, Johanna, and G. Wright Bates. "Ovulation Induction." Obstetrics and Gynecology Clinics of North America 42, no. 1 (March 2015): 27–37. http://dx.doi.org/10.1016/j.ogc.2014.09.007.

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7

SETHIA, DEEPA. "Ovulation Induction." International Journal of Scientific and Research Publications 12, no. 10 (October 24, 2022): 147–48. http://dx.doi.org/10.29322/ijsrp.12.10.2022.p13022.

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8

Balen, Adam. "Ovulation induction." Current Obstetrics & Gynaecology 14, no. 4 (August 2004): 261–68. http://dx.doi.org/10.1016/j.curobgyn.2004.04.005.

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9

Fanchin, R., H. Fernandez, F. Olivennes, and R. Frydman. "Ovulation induction: Ovulation induction in 1995: a new policy." Human Reproduction 10, no. 9 (September 1, 1995): 2224–25. http://dx.doi.org/10.1093/oxfordjournals.humrep.a136272.

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10

Ferreira-Silva, José Carlos, Pábola Santos Nascimento, Marcelo Tigre Moura, Sarah Romini Lima Basto, Marlon Vasconcelos Azevedo, Jorge Motta Rocha, José Pompeu Santos Filho, and Marcos Antonio Lemos Oliveira. "Induction of Ovulation in Mangalarga Marchador Mares by hCG or GnRH." Acta Scientiae Veterinariae 46, no. 1 (March 10, 2018): 6. http://dx.doi.org/10.22456/1679-9216.86667.

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Background: Induction of ovulation is a key procedure for horse assisted reproduction technologies, such as for artificial insemination (AI) and embryo transfer. The application of hCG remains as the primary ovulation-inducing agent for horse assisted reproduction, but alternatives are in demand to avoid its adverse effects, such as loss of ovulation-inducing efficiency over multiple applications by hCC-antibody production. Despite reports on alternative ovulation-inducing agents, pair-wise comparisons of such agents under similar conditions have been limited. Under such scenario, the work was aimed to determine the efficiency of both hCG and Buserelin at inducing ovulation in Mangalarga Marchador mares raised in the Northeast of Brazil under an AI program.Materials, Methods & Results: Mares were initially selected based on their reproductive performance, the absence of clinical-reproductive alterations and adequate body condition score. Mares in diestrus were randomly distributed in three experimental conditions, received 5 mg of Dinoprost and were monitored daily for estrus detection. After estrus detection, ovaries were monitored by ultrasonography, in 12-h intervals, until the follicle reached 35 mm. At this time-point, ovulation was induced with 0.042 mg of Buserelin endovenously, with 3,000 IU hCG by an intramuscular shot, and control mares received 2 mL of saline solution, also by an intramuscular shot. Both hCG and Buserelin displayed similar efficiencies (P > 0.05) for induction of ovulation and that both agents were effective (P < 0.05) for such purpose, since greater percentages (P < 0.05) of induction on mares treated from those of the control. Moreover, the total number of ovulations in mares treated at the end of the experiment was not different (P > 0.05) from those found in the Control. All ovulations occurred within a 72-h period after treatment. It can be observed that in mares treated with hCG or Buserelin, ovulations occurred both in more mares (P < 0.05) and at earlier time-points than mares from the control. It is also possible to note that pregnancy was not different (P > 0.05) between hCG and Buserelin groups, and that pregnancy of mares treated with ovulation-inducing factors was similar to the control.Discussion: The majority of ovulations in mares occurred within initial 48-h after treatment for both hCG and GnRH, suggesting a similar potential for horse assisted reproduction. Both hCG and Buserelin are two commonly used agents for induction of ovulation in mares. As described here, the majority of ovulations occurred within initial 48-h after treatment, a fact which can be attributed to hCG and GnRH activity, since it can happen in intervals from 36 to 48-h after treatment. Pregnancy rates did not differ among groups. These results are under the working hypothesis that hCG and Buserelin would display similar efficiencies on pregnancy rates. Despite the understanding of hCG activity on induction of ovulation due to its high specificity toward LH receptors and results from a direct effect on diminishing estradiol concentration, increasing LH, and further inducing ovulation within 48-h after treatment. In contrast, Buserelin has a similar functional property but acts upon LH synthesis and its release. In conclusion, ovulation in mares can be induced with both hCG and Buserelin, and both ovulation-inducing agents do not affect pregnancy rates.
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11

Naseem, Hafiza S., and Yazan Abdallah. "Induction of ovulation." Obstetrics, Gynaecology & Reproductive Medicine 31, no. 5 (May 2021): 127–30. http://dx.doi.org/10.1016/j.ogrm.2021.03.002.

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12

Balen, A. "Induction of ovulation." Current Obstetrics & Gynaecology 11, no. 4 (August 2001): 233–38. http://dx.doi.org/10.1054/cuog.2001.0182.

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13

McDonough, Paul G., and Gerhard Leyendecker. "GnRH Ovulation Induction." Fertility and Sterility 45, no. 5 (May 1986): 737–38. http://dx.doi.org/10.1016/s0015-0282(16)49354-4.

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14

Metwally, Mostafa, and William L. Ledger. "Induction of ovulation." Obstetrics, Gynaecology & Reproductive Medicine 21, no. 2 (February 2011): 47–51. http://dx.doi.org/10.1016/j.ogrm.2010.11.004.

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15

Nafee, Tamer, and Mostafa Metwally. "Induction of ovulation." Obstetrics, Gynaecology & Reproductive Medicine 24, no. 4 (April 2014): 117–21. http://dx.doi.org/10.1016/j.ogrm.2014.01.009.

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16

Gebeh, Alpha, and Mostafa Metwally. "Induction of ovulation." Obstetrics, Gynaecology & Reproductive Medicine 26, no. 11 (November 2016): 337–40. http://dx.doi.org/10.1016/j.ogrm.2016.08.003.

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17

Land, Jolande A. "11 Ovulation, ovulation induction and ovarian carcinoma." Baillière's Clinical Obstetrics and Gynaecology 7, no. 2 (June 1993): 455–72. http://dx.doi.org/10.1016/s0950-3552(05)80140-3.

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18

Meirow, D., N. Laufer, and J. G. Schenker. "Ovulation induction inin vitrofertilization." Gynecological Endocrinology 6, no. 3 (January 1992): 211–24. http://dx.doi.org/10.3109/09513599209015557.

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19

Mitwally, Mohamed FM, and Robert F. Casper. "Letrozole for ovulation induction." Expert Review of Obstetrics & Gynecology 1, no. 1 (September 2006): 15–27. http://dx.doi.org/10.1586/17474108.1.1.15.

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20

van Wely, Madelon, Claus Yding Andersen, Neriman Bayram, and Fulco van der Veen. "Urofollitropin and Ovulation Induction." Treatments in Endocrinology 4, no. 3 (2005): 155–65. http://dx.doi.org/10.2165/00024677-200504030-00004.

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21

Saravanan, Promodita, and Nidhi Sharma. "GONADOTROPINS IN OVULATION INDUCTION." Journal of Evolution of Medical and Dental Sciences 8, no. 18 (May 6, 2019): 1498–502. http://dx.doi.org/10.14260/jemds/2019/333.

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22

Wallach, Edward E., and Endrika L. Hinton. "Principles of Ovulation Induction." Postgraduate Obstetrics & Gynecology 17, no. 4 (February 1997): 1. http://dx.doi.org/10.1097/00256406-199717040-00001.

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23

Seçkin, N. C., N. Ö. Turhan, and G. Dilmen. "Ovulation Induction andBreast Cancer." Gynecologic and Obstetric Investigation 45, no. 2 (1998): 144. http://dx.doi.org/10.1159/000009943.

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24

Homburg, R. "Ovulation induction in perspective." Human Reproduction Update 8, no. 5 (September 1, 2002): 449–62. http://dx.doi.org/10.1093/humupd/8.5.449.

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25

Pierson, Roger A., Olufemi A. Olatunbosun, and Donna R. Chizen. "Ultrasonography and Ovulation Induction." Journal SOGC 17, no. 8 (August 1995): 739–50. http://dx.doi.org/10.1016/s0849-5831(16)30746-7.

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26

Blacker, Charla M. "Ovulation Stimulation and Induction." Endocrinology and Metabolism Clinics of North America 21, no. 1 (March 1992): 57–84. http://dx.doi.org/10.1016/s0889-8529(18)30232-9.

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27

Amer, Saad. "Gonadotropin induction of ovulation." Obstetrics, Gynaecology & Reproductive Medicine 17, no. 7 (July 2007): 205–10. http://dx.doi.org/10.1016/j.ogrm.2007.06.001.

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28

Macklon, Nick, and BCJM Fauser. "Gonadotrophins in ovulation induction." Reproductive BioMedicine Online 10 (January 2005): 25–31. http://dx.doi.org/10.1016/s1472-6483(11)60387-8.

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29

Hale, L. "S-13 Ovulation induction." Reproductive BioMedicine Online 12 (January 2006): 4. http://dx.doi.org/10.1016/s1472-6483(11)60408-2.

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30

Filicori, Marco. "LH and ovulation induction." Human Reproduction 16, no. 4 (April 2001): 803–4. http://dx.doi.org/10.1093/humrep/16.4.803-a.

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31

ÇELIK, Ç., K. Gezginç, M. Aktan, A. Acar, S. T. Yaman, S. GÜNGÖR, and C. Akyürek. "Effects of ovulation induction on ovarian morphology: an animal study." International Journal of Gynecologic Cancer 14, no. 4 (2004): 600–606. http://dx.doi.org/10.1136/ijgc-00009577-200407000-00005.

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ObjectiveThe aim of this study was to investigate whether the ovulation induction has relation with postneoplastic lesions.Materials and methodsSeventy-eight female, 90-day-old rats were enrolled for the trial. They were divided into three groups. In the first group, 13 rats received one cycle of ovulation induction with Follitropin Beta and human chorionic gonadotropin. The second group of 13 rats received three cycles of ovulation induction, and the third study group consisted of 13 rats which received six cycles of ovulation induction. Each group had a control group consisting of same number of rats that had not received ovulation induction. At the 12th month after the ovulation induction protocols ended, rat ovaries were extirpated for histopathological examination. In histopathological examination, malignant lesions, ovarian cyst and cyst diameter, epithelial stratification, epithelial tufting, mitotic index, polymorphism of epithelial cells and nucleus, epithelial cell nuclear diameter, chromatin density nuclear atypia, and mitotic activity in ovarian cyst epithelium were evaluated.ResultsNo malignant ovarian lesion was found in the three groups. Ovarian cyst development was most frequent in the rats that underwent six cycles of ovulation induction. Epithelial stratification and tufting were most frequent in the rats which underwent ovulation induction six times. Significant difference was found between induction and control groups in second and third groups for cellular and nuclear polymorphism, presence of nucleolus, and nuclear chromatin density.ConclusionsAlthough development of malignant lesion were not found in any of the rat ovaries after ovulation induction, increase in the prevalence of epithelial dysplasia especially with increase in the number of induction cycles shows that some ovarian pathologies can occur subsequent to ovulation induction.
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32

Menkhorst, E., N. Ezard, and L. Selwood. "Induction of ovulation and natural oestrous cycling in the Stripe-faced Dunnart, Sminthopsis macroura." Reproduction 133, no. 2 (February 2007): 495–502. http://dx.doi.org/10.1530/rep-06-0254.

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Induced ovulation allows reproduction by otherwise infertile females, and is ideal for the captive breeding of endangered species where the population is aged or breeding is unsuccessful. A predictable time of ovulation after induction has not yet been achieved in polyovular marsupials. Ovulation was induced in Sminthopsis macroura using an initial injection of 20 IU equine serum gonadotrophin (eSG; Day 0), followed on Day 4 by either 20 IU eSG (n = 25) or 0.5 mg porcine luteinizing hormone (n = 26). I.p. hormone injection was given in the morning or early evening, and reproductive status was established prior to induction. Five non-cyclic animals began to cycle naturally following induction and one gave birth to a litter. The time of ovulation after the 1st injection (7.8 ± 0.9 days) was significantly shorter (P = 0.000) and less variable than the previous study, mimicked the timing of natural cycling, and both natural and induced animals ovulated in the early morning. In vitro oocyte movement through the oviduct, observed for the first time in a marsupial, occurred in pulses. We estimated one group of oocytes could travel the length of the oviduct in 40 min, but it was probably around 4 h. The entire ovulation time (including multiple ovulations) was estimated at 7.5 h. This study has achieved a predictable timing of ovulation after stimulation, and induced noncyclic animals to cycle naturally and give birth, providing a modified methodology for use in captive breeding programs of endangered dasyurid marsupial species with low fecundity.
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33

Casper, Robert F., and Mohamed F. M. Mitwally. "Aromatase Inhibitors for Ovulation Induction." Journal of Clinical Endocrinology & Metabolism 91, no. 3 (March 1, 2006): 760–71. http://dx.doi.org/10.1210/jc.2005-1923.

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Abstract Context: For the last 40 yr, the first line of treatment for anovulation in infertile women has been clomiphene citrate (CC). CC is a safe, effective oral agent but is known to have relatively common antiestrogenic endometrial and cervical mucous side effects that could prevent pregnancy in the face of successful ovulation. In addition, there is a significant risk of multiple pregnancy with CC, compared with natural cycles. Because of these problems, we proposed the concept of aromatase inhibition as a new method of ovulation induction that could avoid many of the adverse effects of CC. The objective of this review was to describe the different physiological mechanisms of action for CC and aromatase inhibitors (AIs) and compare studies of efficacy for both agents for ovulation induction. Evidence Acquisition: We conducted a systematic review of all the published studies, both controlled and noncontrolled, comparing CC and AI treatment, either alone or in combination with gonadotropins, for ovulation induction or augmentation, identified through the Entrez-PubMed search engine. Evidence Synthesis: Because of the recent acceptance of the concept of using AIs for ovulation induction, few controlled studies were identified, and the rest of the studies were pilot or preliminary comparisons. Based on these studies, it appears that AIs are as effective as CC in inducing ovulation, are devoid of any antiestrogenic side effects, result in lower serum estrogen concentrations, and are associated with good pregnancy rates with a lower incidence of multiple pregnancy than CC. When combined with gonadotropins for assisted reproductive technologies, AIs reduce the dose of FSH required for optimal follicle recruitment and improve the response to FSH in poor responders. Conclusions: Preliminary evidence suggests that AIs may replace CC in the future because of similar efficacy with a reduced side effect profile. Although worldwide experience with AIs for ovulation induction is increasing, at present, definitive studies in the form of randomized controlled trials comparing CC with AIs are lacking.
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34

Shanti, Aida, and Ana Murphy. "Surgical Approaches to Ovulation Induction." Seminars in Reproductive Medicine 15, no. 02 (May 1997): 183–91. http://dx.doi.org/10.1055/s-2007-1016300.

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35

Franks, Stephen, and Carole Gilling-Smith. "Advances in induction of ovulation." Current Opinion in Obstetrics and Gynecology 6, no. 2 (April 1994): 136–40. http://dx.doi.org/10.1097/00001703-199404000-00005.

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36

Kafy, Souzan, and Togas Tulandi. "New Advances in Ovulation Induction." Postgraduate Obstetrics & Gynecology 27, no. 20 (October 2007): 1–5. http://dx.doi.org/10.1097/00256406-200710310-00001.

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37

&NA;. "New Advances in Ovulation Induction." Postgraduate Obstetrics & Gynecology 27, no. 20 (October 2007): 6. http://dx.doi.org/10.1097/00256406-200710310-00002.

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38

Gorthi, Srilatha, Adam H. Balen, and Thomas Tang. "Current issues in ovulation induction." Obstetrician & Gynaecologist 14, no. 3 (July 2012): 188–96. http://dx.doi.org/10.1111/j.1744-4667.2012.00117.x.

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39

Meldrum, David. "Ovulation Induction forIn VitroFertilization Procedures." Seminars in Reproductive Medicine 8, no. 03 (August 1990): 213–18. http://dx.doi.org/10.1055/s-2007-1021442.

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40

GUZICK, DAVID S. "Ovulation Induction Management of PCOS." Clinical Obstetrics and Gynecology 50, no. 1 (March 2007): 255–67. http://dx.doi.org/10.1097/grf.0b013e31802f361e.

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41

Fauser, Bart C. J. M. "Revisiting ovulation induction in PCOS." Nature Reviews Endocrinology 10, no. 12 (September 2, 2014): 704–5. http://dx.doi.org/10.1038/nrendo.2014.156.

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42

McDonough, Paul G., Gregory H. Corsan, and Ekkehard Kemmann. "Luteal hCG in Ovulation Induction." Fertility and Sterility 51, no. 3 (March 1989): 549–50. http://dx.doi.org/10.1016/s0015-0282(16)60575-7.

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43

Sovino, Hugo, Teresa Sir-Petermann, and Luigi Devoto. "Clomiphene citrate and ovulation induction." Reproductive BioMedicine Online 4, no. 3 (January 2002): 303–10. http://dx.doi.org/10.1016/s1472-6483(10)61821-4.

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44

Atiomo, William. "Practical Guide to Ovulation Induction." European Journal of Obstetrics & Gynecology and Reproductive Biology 107, no. 2 (April 2003): 223. http://dx.doi.org/10.1016/s0301-2115(02)00409-8.

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45

Ron-El, R. "10 Complications of ovulation induction." Baillière's Clinical Obstetrics and Gynaecology 7, no. 2 (June 1993): 435–53. http://dx.doi.org/10.1016/s0950-3552(05)80139-7.

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46

Brinton, Louise A., Kamran S. Moghissi, Bert Scoccia, Carolyn L. Westhoff, and Emmet J. Lamb. "Ovulation induction and cancer risk." Fertility and Sterility 83, no. 2 (February 2005): 261–74. http://dx.doi.org/10.1016/j.fertnstert.2004.09.016.

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47

Ginsburg, Kenneth A., Timothy R. Yeko, James S. Heiner, and Michael J. Gast. "Adjunctive agents in ovulation induction." American Journal of Obstetrics and Gynecology 172, no. 2 (February 1995): 782–85. http://dx.doi.org/10.1016/0002-9378(95)90154-x.

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48

San Roman, Gabriel, Cecil A. Long, Eli Reshef, William Dodds, and Michael J. Gast. "Monitoring the ovulation induction cycle." American Journal of Obstetrics and Gynecology 172, no. 2 (February 1995): 785–88. http://dx.doi.org/10.1016/0002-9378(95)90155-8.

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49

Fauque, Patricia. "Ovulation induction and epigenetic anomalies." Fertility and Sterility 99, no. 3 (March 2013): 616–23. http://dx.doi.org/10.1016/j.fertnstert.2012.12.047.

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50

Jin, Y. "Induction of ovulation with acupuncture." International Congress Series 1238 (August 2002): 133–39. http://dx.doi.org/10.1016/s0531-5131(02)00410-7.

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