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Journal articles on the topic 'Oxazine derivative'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Sharma, Anupama, Sarita Khaturia, and Har Lal Singh. "Synthesis of New Schiff Base of 1,3-Oxazine and 1,3-Thiazine Derivatives Derived from 4-Phenyl Substituted Chalcones and Evaluation of their Antibacterial Activity." Asian Journal of Chemistry 33, no. 3 (2021): 531–36. http://dx.doi.org/10.14233/ajchem.2021.23050.

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Oxazine and thiazine heterocycles have distinctive interests due to their important class of natural and non-natural products and exhibit high biological activities in the pharmaceutical and biological fields. This work was planned to synthesize Schiff base of 1,3-oxazine and 1,3-thiazine derivative from 4-phenyl substituted chalcones. The structures of the newly synthesized targeted compounds were established from UV, IR, 1H NMR, 13C NMR and DFT calculations. The molecular properties HOMO-LUMO energy, energy gap, softness and harness were calculated using DFT/B3LYP/6-311G (d,p) basis set. in

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2

Farfán, Norberto, Rosa L. Santillan, Dolores Castillo, Reyna Cruz, Pedro Joseph-Nathan, and Jean-Claude Daran. "Fused heterocycles derived from pseudoephedrine and ephedrine." Canadian Journal of Chemistry 70, no. 11 (1992): 2764–70. http://dx.doi.org/10.1139/v92-351.

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The formation of heterobicycles by condensation of (1R, 2R)-(−)-pseudoephedrine or (1R, 2S)-(−)-ephedrine with glyoxal is reported. In the case of pseudoephedrine, the nuclear magnetic resonance data of the crude reaction mixture indicate the presence of three isomeric compounds (5, 6, and 7), which were separated by fractional crystallization, while ephedrine afforded the oxazino-oxazine 8 and the known (5S*,6R*)-4,5-dimethyl-6-phenyl-1,4-oxazin-2-one (9). Conclusive spectroscopic evidence for the structures of the new compounds having the cis-[1,4]oxazino[3,2-b]-1,4-oxazine (5 and 8) and the

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3

Kirila, Tatyana, Anna Smirnova, Alla Razina, Andrey Tenkovtsev, and Alexander Filippov. "Synthesis and Conformational Characteristics of Thermosensitive Star-Shaped Six-Arm Polypeptoids." Polymers 12, no. 4 (2020): 800. http://dx.doi.org/10.3390/polym12040800.

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Star-shaped six-arm poly-2-alkyl-2-oxazine and poly-2-alkyl-2-oxazoline with hexaaza [26]orthoparacyclophane derivative core were synthesized successfully using cationic ring-opening polymerization. Conformational behavior of prepared polymer stars were investigated by the methods of molecular hydrodynamics and optics in molecular dispersed solutions. It was shown that conformation characteristics of star-shaped polypeptoids depends on arm length, while the chemical structure weakly affects the behavior of the studied polymers in solutions. This behavior is caused by the close equilibrium rigi

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4

Bes, T., A. Hajnal, G. Schneider, M. Noltemeyer, and J. Wölfling. "A Steroidal Dihydro-1,3-oxazine Derivative." Acta Crystallographica Section C Crystal Structure Communications 54, no. 3 (1998): 372–73. http://dx.doi.org/10.1107/s0108270197016338.

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5

Hewitt, Manuel, Thomas R. Schneider, Zsuzsanna Szemerédi, Andrea Hajnal, Janos Wölfling, and Gyula Schneider. "A steroidal phenyldihydro-1,3-oxazine derivative." Acta Crystallographica Section C Crystal Structure Communications 56, no. 8 (2000): e363-e364. http://dx.doi.org/10.1107/s0108270100009628.

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6

Arole, Aishwarya H., Prashant Deshmukh, Ashok Sridhar, and Balasundaram Padmanabhan. "Structural investigation of a pyrano-1,3-oxazine derivative and the phenanthridinone core moiety against BRD2 bromodomains." Acta Crystallographica Section F Structural Biology Communications 78, no. 3 (2022): 119–27. http://dx.doi.org/10.1107/s2053230x22001066.

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The BET (bromodomain and extra-terminal) family of proteins recognize the acetylated histone code on chromatin and play important roles in transcriptional co-regulation. BRD2 and BRD4, which belong to the BET family, are promising drug targets for the management of chronic diseases. The discovery of new scaffold molecules, a pyrano-1,3-oxazine derivative (NSC 328111; NS5) and phenanthridinone-based derivatives (L10 and its core moiety L10a), as inhibitors of BRD2 bromodomains BD1 and BD2, respectively, has recently been reported. The compound NS5 has a significant inhibitory effect on BRD2 in

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7

Zhang, Tong, Jun Wang, Tiantian Feng, et al. "A novel high performance oxazine derivative: design of tetrafunctional monomer, step-wise ring-opening polymerization, improved thermal property and broadened processing window." RSC Advances 5, no. 42 (2015): 33623–31. http://dx.doi.org/10.1039/c5ra02839f.

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A novel tetrafunctional oxazine monomer containing benzoxazine and fluorene-oxazine was prepared for the first time using a Mannich condensation reaction of 2,7-dihydroxy-9,9-bis-(4-hydroxyphenyl)fluorene with paraformaldehyde and n-butylamine.

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8

Ravikumar, Krishnan, Balasubramanian Sridhar, Jagadeesh Babu Nanubolu, Venkatasubramanian Hariharakrishnan, and Awadesh Narain Singh. "Structures of benzoxazine-fused triazoles as potential diuretic agents." Acta Crystallographica Section C Crystal Structure Communications 68, no. 8 (2012): o302—o307. http://dx.doi.org/10.1107/s0108270112029800.

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6,8-Dinitro-2,4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-1-one, C9H5N5O6, (I), a potential diuretic, and its acetylacetone derivative (E)-2-(2-hydroxy-4-oxopent-2-en-3-yl)-6,8-dinitro-2,4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]oxazin-1-one, C14H11N5O8, (II), both crystallize from methanol but in centrosymmetric and noncentrosymmetric space groups, respectively. To the best of our knowledge, this is the first report of crystal structures of benzoxazine–triazole fused systems. The acetylacetone group in (II) exists as the keto–enol tautomer and is oriented perpendicular to the

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9

Pattaweepaiboon, Supak, Natchayapak Phiromphu, Narongpol Kaewchangwat, Khomson Suttisintong, and Weekit Sirisaksoontorn. "An indolino-spironaphthooxazine probe for colorimetric detection of ferric ions in drinking water." New Journal of Chemistry 45, no. 25 (2021): 11284–91. http://dx.doi.org/10.1039/d1nj01166a.

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The sensing performance of a novel indolino-spironaphthooxazine derivative (SPNO), 6′(3,4-dihydroisoquinolin-2(1H)-yl)-3,3-dimethyl-1-phenethylspiro[indoline-2,3′-naphtho[2,1-b][1,4]oxazine], was investigated for rapid colorimetric detection of ferric ions (Fe<sup>3+</sup>) in drinking water.

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10

BES, T., A. HAJNAL, G. SCHNEIDER, M. NOLTEMEYER, and J. WOELFLING. "ChemInform Abstract: A Steroidal Dihydro-1,3-oxazine Derivative." ChemInform 29, no. 29 (2010): no. http://dx.doi.org/10.1002/chin.199829232.

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11

Rivera, Augusto, Jicli José Rojas, Jaime Ríos-Motta, and Michael Bolte. "Crystal structure of 1-[(2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazin-2-yl)methyl]naphthalen-2-ol: a possible candidate for new polynaphthoxazine materials." Acta Crystallographica Section E Crystallographic Communications 71, no. 9 (2015): 1089–92. http://dx.doi.org/10.1107/s2056989015015583.

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In the title compound, C23H19NO2, an oxazine Mannich base derivative, the oxazine ring has a half-chair conformation. The 2-hydroxynaphthalen-1-yl substituent is placed in an axial position. There is an intramolecular O—H...N hydrogen bond, forming anS(6) graph-set motif. In the crystal, molecules are connected by a pair of C—H...π interactions into an inversion dimer, which is reinforced by another pair of weak C—H...π interactions. The dimers are linked by a π–π interaction [centroid-centroid distance = 3.6268 (17) Å], consolidating a column along theaaxis. Furthermore, the columns interact

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12

Mohareb, Rafat Milad, Rehab Ali Ibrahim, Amira Mohamed Elmetwally, and Marwa Soliman Gamaan. "Synthesis of Fused Quinoline Derivatives with Antiproliferative Activities and Tyrosine Kinases, Pim-1 Kinase Inhibitions." Acta Chimica Slovenica 69, no. 1 (2022): 13–29. https://doi.org/10.17344/acsi.2021.6733.

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Cyclohexan-1,3-dione (1) reacted with either 2-aminoprop-1-ene-1,1,3-tricarbonitrile (2a) or diethyl 3-amino-2-cyanopent-2-enedioate (2b) to give the 5,6,7,8-tetrahydronaphthalene derivatives 3a and 3b, respectively. The latter compounds underwent further heterocyclization reactions to give the thieno[2’,3’:5,6]benzo[1,2-e][1,3]oxazine derivatives. On the other hand, the reaction of compound 1 with trichloroacetonitrile afforded the (2,2,2-trichloroethylidene)cyclohexane derivative 14. The latter underwent a series of reactions to produce 2,3,6,7-tetrahydroquinazoline, dihydrothieno[2,3-h]isoq

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13

Ananthula, Suryatheja, Parash Parajuli, Fathy A. Behery та ін. "δ-Tocotrienol Oxazine Derivative Antagonizes Mammary Tumor Cell Compensatory Response to CoCl2-Induced Hypoxia". BioMed Research International 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/285752.

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In response to low oxygen supply, cancer cells elevate production of HIF-1α, a hypoxia-inducible transcription factor that subsequently acts to stimulate blood vessel formation and promote survival. Studies were conducted to determine the role ofδ-tocotrienol and a semisyntheticδ-tocotrienol oxazine derivative, compound44, on +SA mammary tumor cell hypoxic response. Treatment with 150 µM CoCl2induced a hypoxic response in +SA mammary tumor cells as evidenced by a large increase in HIF-1αlevels, and combined treatment with compound44attenuated this response. CoCl2-induced hypoxia was also assoc

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14

Gaonkar, Santosh L., Vignesh U. Nagaraj, and Swarnagowri Nayak. "A Review on Current Synthetic Strategies of Oxazines." Mini-Reviews in Organic Chemistry 16, no. 1 (2018): 43–58. http://dx.doi.org/10.2174/1570193x15666180531092843.

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In the past three decades, the heterocyclic oxazine cores have been intensely concerned. Oxazine derivatives are promising vital heterocyclic motifs. They are eminent for their synthetic potential and extensive biological properties. Oxazines are versatile intermediates for the synthesis of a variety of heterocycles and bifunctional compounds. Researchers have reported several synthetic approaches for the preparation of oxazines. This review emphasises the recent approaches for the synthesis of oxazine derivatives.

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15

Haggam, Reda Ahmed, Mohamed Gomma Assy, Mohamed Hassan Sherif, and Mohamed Mohamed Galahom. "A series of 1,3-imidazoles and triazole-3-thiones based thiophene-2-carboxamides as anticancer agents: Synthesis and anticancer activity." European Journal of Chemistry 9, no. 2 (2018): 99–106. http://dx.doi.org/10.5155/eurjchem.9.2.99-106.1701.

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By addition of semicarbazide or phenylhydrazine hydrochloride to thienoylisothiocyanate (1) resulted in building of thiosemicarbazide derivative (2), triazole derivative (4) and thiophene-2-carboxamide (5), respectively. Basic cyclization of compound 2 led to formation of oxadiazine (3). Synthesis of thiadiazine derivative (6) was achieved via reaction of compound 5 and maleic anhydride in triethyl amine. Heating of compound 5 with ethyl chloroacetate or sodium ethoxide produced thiadiazine derivative (7) and triazolethione (8), respectively. Thiosemicarbazide derivative 11 was synthesized by

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16

Antonova, Yulia A., Yulia V. Nelyubina, Sema L. Ioffe, and Andrey A. Tabolin. "[3+3]-Annulation of Cyclic Nitronates with Vinyl Diazoacetates: Diastereoselective Synthesis of Partially Saturated [1,2]Oxazino[2,3-b][1,2]oxazines and Their Base-Promoted Ring Contraction to Pyrrolo[1,2-b][1,2]oxazine Derivatives." Molecules 28, no. 7 (2023): 3025. http://dx.doi.org/10.3390/molecules28073025.

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A rhodium(II)-catalyzed reaction of cyclic nitronates (5,6-dihydro-4H-1,2-oxazine N-oxides) with vinyl diazoacetates proceeds as a [3+3]-annulation producing bicyclic unsaturated nitroso acetals (4a,5,6,7-tetrahydro-2H-[1,2]oxazino[2,3-b][1,2]oxazines). Optimization of reaction conditions revealed the use of Rh(II) octanoate as the preferred catalyst in THF at room temperature, which allows the preparation of target products in good yields and excellent diastereoselectivity. Under basic conditions, namely, the combined action of DBU and alcohol, these nitroso acetals undergo ring contraction o

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17

Kandziora, Maja, and Hans-Ulrich Reissig. "Synthesis of rigid p-terphenyl-linked carbohydrate mimetics." Beilstein Journal of Organic Chemistry 10 (July 30, 2014): 1749–58. http://dx.doi.org/10.3762/bjoc.10.182.

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An approach to β-D-2-aminotalose- and β-D-2-aminoidose-configured carbohydrate mimetics bearing a phenyl substituent is described. Unnatural divalent rigid p-terphenyl-linked C-aryl glycosides with 2.0 nm dimension are available using Suzuki cross-couplings. The key compound, a p-bromophenyl-substituted 1,2-oxazine, was prepared by a stereoselective [3 + 3]-cyclization of a D-isoascorbic acid-derived (Z)-nitrone and lithiated TMSE-allene. The Lewis acid-induced rearrangement of this heterocycle provided the corresponding bicyclic 1,2-oxazine derivative that may be regarded as internally protec

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18

Medvedeva, Svetlana M., Alexey V. Movchan, Ksenia A. Bondarenko, Ksenia Dz Shikhalieva, and Khidmet S. Shikhaliev. "Preparation of individual derivatives in 1,3-oxazino[5,4,3-ij]quinolines and 1,4-oxazino[2,3,4-ij]quinolines series by column chromatography and their mass spectrometric study." Сорбционные и хроматографические процессы 23, no. 4 (2023): 705–15. http://dx.doi.org/10.17308/sorpchrom.2023.23/11577.

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Hundreds of highly effective compounds that have a complex of practically useful properties are known among tricyclic hydroquinolines. Therefore, the production of new compounds of high purity in this series and identification of the features of their behaviour under the influence of electron impact for the determination of their structures is important. Previously, we synthesized 1,3-oxazino[5,4,3-ij]quinoline-1,3-diones and 1,4-oxazino[2,3,4-ij]quinoline-2,3-diones, but the nature of the mass spectral decay for the determination of their structures was not discussed. In this study, using thi

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19

Fu, Peng, and John B. MacMillan. "Carpatizine, a novel bridged oxazine derivative generated by non-enzymatic reactions." Organic & Biomolecular Chemistry 15, no. 25 (2017): 5275–78. http://dx.doi.org/10.1039/c7ob01178d.

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20

Zainab Hassan Rahim and Nadia Sadiq Majeed. "Synthesis and Characterization of some new heterocyclic derivatives from terphthaldehyde and study of their biological activity." Journal of Kufa for Chemical Sciences 3, no. 1 (2023): 223–39. http://dx.doi.org/10.36329/jkcm/2023/v3.i1.12260.

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In this study, some new heterocyclic compounds have been synthesized including the preparation of some chalcone from the reaction terphthadehyde with two moles of ketone derivative p-hydroxy acetophenone in a basic medium, After that . The stage includes the preparation of new heterocyclic compounds five-membered ( pyrazole, Isoxazole) and six-membered ( oxazine, thiazine). The prepared compounds were characterized by FT-IR,1H-NMR, and 13C-NMR techniqes, in addition to their melting points and TLC (Thin Layer Chromatography).Finally,the prepared compounds are tested against Gram-positive and G

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21

Thirunarayanan, Ganesamoorthy, R. Sundararajan, and R. Arulkumaran. "Aryl Chalcones as Efficient Precursors for Deriving Oxazine: Solvent-Free Synthesis and Antimicrobial Activities of some Oxazine-2-amines." International Letters of Chemistry, Physics and Astronomy 23 (November 2013): 82–97. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.23.82.

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A series of some oxazine derivatives has been synthesised by fly-ash:H2SO4 catalyzed solvent-free cyclization of aryl chalcones and urea under microwave irradiation. The yields of the oxazines were more than 85%. The synthesised oxazines were characterized by their physical constants, analytical and spectroscopic data. The antimicrobial activities of these oxazines have been studied using Bauer-Kirby method.

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22

Thirunarayanan, Ganesamoorthy, R. Sundararajan, and R. Arulkumaran. "Aryl Chalcones as Efficient Precursors for Deriving Oxazine: Solvent-Free Synthesis and Antimicrobial Activities of some Oxazine-2-amines." International Letters of Chemistry, Physics and Astronomy 23 (November 30, 2013): 82–97. http://dx.doi.org/10.56431/p-cks63d.

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A series of some oxazine derivatives has been synthesised by fly-ash:H2SO4 catalyzed solvent-free cyclization of aryl chalcones and urea under microwave irradiation. The yields of the oxazines were more than 85%. The synthesised oxazines were characterized by their physical constants, analytical and spectroscopic data. The antimicrobial activities of these oxazines have been studied using Bauer-Kirby method.

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23

Farghaly, Thoraya A., and Kamal M. Dawood. "Inhibitory Activities of Pyrazolo-Oxazine Heterocyclic Derivatives." Mini-Reviews in Medicinal Chemistry 22, no. 9 (2022): 1256–67. http://dx.doi.org/10.2174/1389557522666211229114446.

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Abstract: Despite several reports and reviews addressing the biological significance of pyrazoles and oxazines, no comprehensive work on the pyrazolo oxazine fused ring system has been published so far. We report all biological evaluations on pyrazolo-oxazine derivatives in this mini-review to provide an avenue for medicinal and pharmacological researchers to conduct further in-depth exploration.

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24

Li, Hong, Meili Pang, Bianpeng Wu, and Jiben Meng. "Synthesis, crystal structure and photochromism of a novel spiro[indoline–naphthaline]oxazine derivative." Journal of Molecular Structure 1087 (May 2015): 73–79. http://dx.doi.org/10.1016/j.molstruc.2015.01.050.

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25

Journal, Baghdad Science. "Synthesis, Characterization of Poly Heterocyclic Compounds, and Effect on Cancer Cell (Hep-2) In vitro." Baghdad Science Journal 15, no. 4 (2018): 415–524. http://dx.doi.org/10.21123/bsj.15.4.415-524.

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A synthesis series of new heterocyclic derivatives (A2-A7) (pyrrole, pyridazine, oxazine and imidazol) derived from 4-acetyl-2,5-dichloro-1-(3,5-dinitrophenyl)-1H-pyrrole-3-carboxylate(A1) have been synthesised. Synthesis of compound (A2) by the reaction of starting material (A1) with hydroxyl amine hydrochloride in the presence of pyridine. Compound (A2) was reacted with hydrazine hydrate in dry benzene to give (A3) derivative. The compound )A3( deals with sodium nitrite to give diazonium salt, and the reaction diazonium salt with ethyl acetoacetate to produce compound (A4). To a mixture of c

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26

Medvecký, Michal, Igor Linder, Luise Schefzig, Hans-Ulrich Reissig, and Reinhold Zimmer. "Iodination of carbohydrate-derived 1,2-oxazines to enantiopure 5-iodo-3,6-dihydro-2H-1,2-oxazines and subsequent palladium-catalyzed cross-coupling reactions." Beilstein Journal of Organic Chemistry 12 (December 29, 2016): 2898–905. http://dx.doi.org/10.3762/bjoc.12.289.

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Iodination of carbohydrate-derived 3,6-dihydro-2H-1,2-oxazines of type 3 using iodine and pyridine in DMF furnished 5-iodo-substituted 1,2-oxazine derivatives 4 with high efficacy. The alkenyl iodide moiety of 1,2-oxazine derivatives syn-4 and anti-4 was subsequently exploited for the introduction of new functionalities at the C-5 position by applying palladium-catalyzed carbon–carbon bond-forming reactions such as Sonogashira, Heck, or Suzuki coupling reactions as well as a cyanation reaction. These cross-coupling reactions led to a series of 5-alkynyl-, 5-alkenyl-, 5-aryl- and 5-cyano-substi

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27

Lasri, Jamal, Naser E. Eltayeb, Saied M. Soliman, Ehab M. M. Ali, Sultan Alhayyani, and Abdullah Akhdhar. "Synthesis, Crystal Structure, DFT, and Anticancer Activity of Some Imine-Type Compounds via Routine Schiff Base Reaction: An Example of Unexpected Cyclization to Oxazine Derivative." Molecules 28, no. 12 (2023): 4766. http://dx.doi.org/10.3390/molecules28124766.

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The synthesis, characterization, and anticancer properties of three imine-type compounds 1–3 and an unexpected oxazine derivative 4 are presented. The reaction of p-dimethylaminobenzaldehyde or m-nitrobenzaldehyde with hydroxylamine hydrochloride afforded the corresponding oximes 1–2 in good yields. Additionally, the treatment of benzil with 4-aminoantipyrine or o-aminophenol was investigated. Routinely, the Schiff base (4E)-4-(2-oxo-1,2-diphenylethylideneamino)-1,2-dihydro-1,5-dimethyl-2-phenylpyrazol-3-one 3 was obtained in the case of 4-aminoantipyrine. Unexpectedly, the reaction of benzil

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28

Lauro, Figueroa-Valverde, Díaz-Cedillo Francisco, Rosas-Nexticapa Marcela, et al. "Design and Synthesis of Two Oxazine Derivatives Using Several Strategies." Journal of Chemistry 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/757953.

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Several oxazine derivatives have been synthesized; nevertheless, expensive reagents and special conditions are required. Therefore, in this study, two oxazine derivatives (2-chloro-3-{{2-[-(3-chloro-2-oxo-cyclobutyl)-(2,3-dimethoxy-9,10-dihydrostrychnid-10-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3-oxazin-2-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone and 2-chloro-3-{{2-[(3-chloro-2-oxo-cyclobutyl)-(1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3]oxazin-2-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone

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29

Gümüş, M. K., S. Kansız, G. B. Tulemisova, and N. Dege. "SYNTHESIS, CRYSTAL STRUCTURE, AND HIRSHFELD SURFACE ANALYSIS OF 4,4A,5,6,7,8-HEXAHYDRO-4A-METHYL-2,5,7-TRIPHENYL-2H-PYRIDO[4,3-D][1,3]OXAZINE." Журнал структурной химии 66, no. 2 (2025): 139916. http://dx.doi.org/10.26902/jsc_id139916.

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The synthesis of the 2,6-diphenyldpiperidin-4-one derivative of the title compound, 4,4a,5,6,7,8-hexahydro-4a-methyl-2,5,7-triphenyl-2H-pyrido[4,3-d][1,3]oxazine (HMTPO), was developed using the reaction of 4-hydroxy-3-methyl-2-butanone, benzaldehyde, and ammonium acetate in ethanol as a solvent. The molecular structure of HMTPO was determined by single-crystal X-ray diffraction. The chemical structure was confirmed by employing IR, 1H NMR, 13C NMR, and mass spectral data. To gain deeper insight into the bonding interactions within the compound, Hirshfeld surface analysis and two-dimensional f

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30

Mondal, Sandip, Sachinath Bera, Suvendu Maity, and Prasanta Ghosh. "Cobalt Ion Promoted Redox Cascade: A Route to Spiro Oxazine-Oxazepine Derivatives and a Dinuclear Cobalt(III) Complex of an N-(1,4-Naphthoquinone)-o-aminophenol Derivative." Inorganic Chemistry 56, no. 21 (2017): 13194–204. http://dx.doi.org/10.1021/acs.inorgchem.7b01961.

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31

Tiwari, Ram Prakash, Krishna Srivastava, Abhishek Srivastava, Shailesh Kumar Mishra, and Amit Tripathi. "Synthesis and Biological evalution of heterocyclic oxazine-2-carbonothioyl)quinazolin-4(3H)-one and oxazine-2(3H)-carbothioamide derivatives." Research Journal of Chemistry and Environment 27, no. 11 (2023): 60–71. http://dx.doi.org/10.25303/2711rjce060071.

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An efficient route for the preparation of novel heterocyclic oxazine-carbonothioyl-quinazolin-(3H)-one and oxazine-(3H)-carbothioamide derivatives is through synthesis of 2-phenyl-4H-benzo[d][1,3] oxazin-4-one(anthranilic acid and benzoyl chlordide) which further reacts with thiourea and thiosemicarbazide to give substituted amines, which formed oxo-2-phenylquinazoline-3(4H)-carbothioa mide and oxo-2-phenylquinazolin-3(4H)-yl)thiourea (β-naphthol,substituted aromatic formedehyde). The structures of all the prepared derivatives were elucidated by using UV-Vis IR, 1HNMR and Mass spectral studies

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32

Kasprzyk, Wiktor, Tomasz Świergosz, and Filip Koper. "Fluorescence Assay for the Determination of d-Panthenol Based on Novel Ring-Fused 2-Pyridone Derivative." International Journal of Molecular Sciences 21, no. 21 (2020): 8386. http://dx.doi.org/10.3390/ijms21218386.

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Herein, a novel fluorescent method for the determination of d-panthenol (DP) level in solutions with no separate hydrolysis step has been revealed based on the utilization of citric acid (CA) as a derivatizing agent. Consequently, the essential parameters of the derivatization process were established, resulting in the development of sensitive, repeatable, and accurate determination of panthenol. The method was approved, and its usefulness in characterizing the concentration of DP in pharmaceutical formulations and selectivity in the determination of DP were validated. The chemical structure o

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33

Chovatiya, Pankaj, Charmy Mehta, Hardik Senjani, Anamik Shah, and Hitendra S. Joshi. "Synthesis and Characterization of some New Schiff Bases of 2-Oxonaphtho[2,1-b][1,4]Oxazine." International Letters of Chemistry, Physics and Astronomy 31 (March 2014): 26–30. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.31.26.

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The literature review reveal that [1,4]-oxazine derivatives represent one of the most active classes of compounds possessing wide spectrum of biodynamic activities and use as potent therapeutic agents. In the present work, a series of Schiff base of 2-(2,3-dihydro-2-oxonaphtho[2,1-b][1,4]oxazin-1-yl)acetohydrazide, 5a-5j has been synthesized using 1-aminonaphthalen-2-ol. Various aromatic aldehyde were react with carbohydrazide 4 in the presence of acid to produce the 2-oxonaphtho[2,1-b][1,4]oxazin Schiff base derivatives with good yields. All synthesized compounds were characterized by IR, NMR

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34

Chovatiya, Pankaj, Charmy Mehta, Hardik Senjani, Anamik Shah, and Hitendra S. Joshi. "Synthesis and Characterization of some New Schiff Bases of 2-Oxonaphtho[2,1-b][1,4]Oxazine." International Letters of Chemistry, Physics and Astronomy 31 (March 28, 2014): 26–30. http://dx.doi.org/10.56431/p-126pe5.

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The literature review reveal that [1,4]-oxazine derivatives represent one of the most active classes of compounds possessing wide spectrum of biodynamic activities and use as potent therapeutic agents. In the present work, a series of Schiff base of 2-(2,3-dihydro-2-oxonaphtho[2,1-b][1,4]oxazin-1-yl)acetohydrazide, 5a-5j has been synthesized using 1-aminonaphthalen-2-ol. Various aromatic aldehyde were react with carbohydrazide 4 in the presence of acid to produce the 2-oxonaphtho[2,1-b][1,4]oxazin Schiff base derivatives with good yields. All synthesized compounds were characterized by IR, NMR

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35

Deshmukh, Prashant, Shruti Mathur, Gejo Gangadharan, Gopinatha Krishnappa, Nandakumar Dalavaikodihalli Nanjaiah, and Balasundaram Padmanabhan. "Novel pyrano 1,3 oxazine based ligand inhibits the epigenetic reader hBRD2 in glioblastoma." Biochemical Journal 477, no. 12 (2020): 2263–79. http://dx.doi.org/10.1042/bcj20200339.

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Glioblastoma (GBM) is the most common primary brain malignancy, rarely amenable to treatment with a high recurrence rate. GBM are prone to develop resistance to the current repertoire of drugs, including the first-line chemotherapeutic agents with frequent recurrence, limiting therapeutic success. Recent clinical data has evidenced the BRD2 and BRD4 of the BET family proteins as the new druggable targets against GBM. In this relevance, we have discovered a compound (pyrano 1,3 oxazine derivative; NSC 328111; NS5) as an inhibitor of hBRD2 by the rational structure-based approach. The crystal st

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Hintersteiner, Martin, Albert Enz, Peter Frey та ін. "In vivo detection of amyloid-β deposits by near-infrared imaging using an oxazine-derivative probe". Nature Biotechnology 23, № 5 (2005): 577–83. http://dx.doi.org/10.1038/nbt1085.

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Dabaeva, V. V., M. R. Bagdasaryan, E. G. Paronikyan, and Sh Sh Dashyan. "Synthesis of New Fused Thieno[3,2-d]pyrimidines Based on Thieno[3,2-d][1,3]oxazine Derivative." Russian Journal of General Chemistry 89, no. 4 (2019): 847–51. http://dx.doi.org/10.1134/s1070363219040340.

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38

Mohammed, Tiba Ibrahim, Shurooq Abbas Hassan, Abbas K. Abbas, and Rawaa N. Abdulazeez. "Synthesis of Heterocyclic Compounds Via Chalcone Derivatives and Study Activity of Some these Compounds as Pesticides (Anti-Dubas)." International Journal Papier Advance and Scientific Review 4, no. 2 (2023): 1–9. http://dx.doi.org/10.47667/ijpasr.v4i2.207.

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In this research, we synthesized oxazine and thiazine derivatives (3-6). These derivatives of chacone compounds (1 and 2) that synthesized from 4- hydroxyacetophenone and aldehyde derivatives such as, 4-bromobenzaldehyde and 4- chlorobenzaldehyde. These derivatives of chalcone (1-2) reacted with urea to produce oxazine derivatives as 4-[4-amino-6-(4-subsutitedphenyl)-2H-1,3-oxazin-2-yl] phenol (3 and 4) and thiourea to produce 4-[4-amino-6-(4-subsutitedphenyl)-2H-1,3-thiazin-2-yl] phenol (5 and 6). These derivatives were characterization by spectroscopy methods such as, FTIR and 1HNMR. Some co

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Jasiński, Marcin, Dieter Lentz, and Hans-Ulrich Reissig. "Carbohydrate-auxiliary assisted preparation of enantiopure 1,2-oxazine derivatives and aminopolyols." Beilstein Journal of Organic Chemistry 8 (April 30, 2012): 662–74. http://dx.doi.org/10.3762/bjoc.8.74.

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An approach to enantiopure hydroxylated 2H-1,2-oxazine derivatives is presented utilizing the [3 + 3] cyclisation of lithiated alkoxyallenes and an L-erythrose-derived N-glycosyl nitrone as precursors. This key step proceeded only with moderate diastereoselectivity, but allowed entry into both enantiomeric series of the resulting 3,6-dihydro-2H-1,2-oxazines. Their enol ether double bond was then subjected to a hydroboration followed by an oxidative work-up, and finally the auxiliary was removed. The described three-step procedure enabled the synthesis of enantiopure hydroxylated 1,2-oxazines.

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Yang, Weiguang, Zitong Zhou, Yu Zhao, et al. "Copper Catalyzed Inverse Electron Demand [4+2] Cycloaddition for the Synthesis of Oxazines." Catalysts 12, no. 5 (2022): 526. http://dx.doi.org/10.3390/catal12050526.

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A copper catalyzed tandem CuAAC/ring cleavage/[4+2] annulation reaction of terminal ynones, sulfonyl azides, and imines has been developed to synthesize the functionalized oxazines under mild conditions. Particularly, the intermediate N-sulfonyl acylketenimines undergo cycloaddition of an inverse electron demand Diels–Alder reaction with imines and a series of 1,3-oxazine derivatives were obtained successfully in good yields.

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Hsu, Ling-Yih, Dean S. Wise, John C. Drach, and Leroy B. Townsend. "Synthesis of 1-Hydroxy-10-methyl-pyrimido [1, 6-C][1, 3]oxazine and the Oxazepine Derivative, Structural Mimicry of Anti-Constrained Acyclic Thymidine." Nucleosides and Nucleotides 15, no. 9 (1996): 1481–93. http://dx.doi.org/10.1080/07328319608002449.

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42

HSU, L. Y., D. S. WISE, J. C. DRACH, and L. B. TOWNSEND. "ChemInform Abstract: Synthesis of 1-Hydroxy-9-methyl-pyrimido(1,6-C) (1,3)oxazine and the Oxazepine Derivative, Structural Mimicry of anti-Constrained Acyclic Thymidine." ChemInform 28, no. 2 (2010): no. http://dx.doi.org/10.1002/chin.199702190.

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Abbas, Tariq R., J. I. G. Cadogan, Allan A. Doyle, et al. "Intramolecular ring cleavage of chiral terpenoid-derived oxazinone via asymmetric anti-aldol reaction: Unexpected entry to a N-substituted tetrahydro-1,3-oxazine-2,4-dione derivative." Tetrahedron Letters 38, no. 27 (1997): 4917–20. http://dx.doi.org/10.1016/s0040-4039(97)01058-7.

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Bremner, JB, EJ Browne, LM Engelhardt, CS Greenwood, and AH White. "Preparation of Thieno[3,2-e][1,2]oxazepine, Thieno and [1]Benzothieno-[3,2-g][1,4]oxazonine, and 5H-Thieno and 1H-[1]Benzothieno-[3,2-h][1,5]oxazecine Derivatives by Ring Expansion Methods. X-Ray Crystal Structure of 1-Phenyl-1,3,4,5,6,7-hexahydro[1]benzothieno-[3,2-g][1,4]oxazonine-5-carbonitrile." Australian Journal of Chemistry 41, no. 12 (1988): 1815. http://dx.doi.org/10.1071/ch9881815.

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10-Phenyl-4,5,6,7,8,10-hexahydrothieno[3,2-g][1,4]oxazonine-6-carbonitrile (6a) and 11-phenyl-4,6,7,8,9,11-hexahydro-5H-thieno[3,2-h][1,5]oxazecine-6-carbonitrile (7a) were prepared in moderate yields by cyanogen bromide-induced ring expansion of tetrahydrothieno [2,3- c] pyridinylalkanol precursors (4a) and (5a), respectively. 1-Phenyl-1,3,4,5,6,7-hexahydro[1]- benzothieno [3,2-g][1,4]oxazonine-5-carbonitrile (6b) and 1-phenyl-3,4,5,6,7,8-hexahydro-1H- [1] benzothieno [3,2-h][1,5]oxazecine-6-carbonitrie (7b) were similarly prepared from the [1] benzothieno [2,3-c] pyridinylalkanol precursors

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Carlucci, G., S. Guadagni, and G. Palumbo. "Determination of Ofloxacin, A New Oxazine Derivative in Human Serum, Urine, and Bile by High-Performance Liquid Chromatography." Journal of Liquid Chromatography 9, no. 11 (1986): 2539–47. http://dx.doi.org/10.1080/01483918608076882.

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Tasneen, Rokeya, Kathy Williams, Opokua Amoabeng, et al. "Contribution of the Nitroimidazoles PA-824 and TBA-354 to the Activity of Novel Regimens in Murine Models of Tuberculosis." Antimicrobial Agents and Chemotherapy 59, no. 1 (2014): 129–35. http://dx.doi.org/10.1128/aac.03822-14.

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ABSTRACTNew regimens based on two or more novel agents are sought in order to shorten or simplify the treatment of both drug-susceptible and drug-resistant forms of tuberculosis. PA-824 is a nitroimidazo-oxazine now in phase II trials and has shown significant early bactericidal activity alone and in combination with the newly approved agent bedaquiline or with pyrazinamide with or without moxifloxacin. While the development of PA-824 continues, a potential next-generation derivative, TBA-354, has been discovered to havein vitropotency superior to that of PA-824 and greater metabolic stability

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Bouché, Léa, and Hans-Ulrich Reissig. "Synthesis of novel carbohydrate mimetics via 1,2-oxazines." Pure and Applied Chemistry 84, no. 1 (2011): 23–36. http://dx.doi.org/10.1351/pac-con-11-09-20.

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The combination of lithiated alkoxyallenes with carbohydrate-derived nitrones constitutes a flexible entry to highly functionalized enantiopure 1,2-oxazine derivatives. They can be used as precursors for acyclic and cyclic carbohydrate-like products such as amino sugar alcohols, azetidine and pyrrolidine derivatives. The Lewis acid-promoted rearrangement of 1,3-dioxolanyl-substituted 1,2-oxazines to bicyclic compounds allows an efficient route to novel amino pyran and oxepane derivatives. After subsequent transformations, new carbohydrate mimetics or “real” carbohydrates were obtained in good

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Alcaide, Benito, Pedro Almendros, M. Teresa Quirós, and Israel Fernández. "Gold-catalyzed oxycyclization of allenic carbamates: expeditious synthesis of 1,3-oxazin-2-ones." Beilstein Journal of Organic Chemistry 9 (April 26, 2013): 818–26. http://dx.doi.org/10.3762/bjoc.9.93.

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A combined experimental and computational study on regioselective gold-catalyzed synthetic routes to 1,3-oxazinan-2-ones (kinetically controlled products) and 1,3-oxazin-2-one derivatives (thermodynamically favored) from easily accessible allenic carbamates has been carried out.

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Marmé, Nicole, Gregor Habl, and Jens-Peter Knemeyer. "Aggregation behavior of the red-absorbing oxazine derivative MR 121: A new method for determination of pure dimer spectra." Chemical Physics Letters 408, no. 4-6 (2005): 221–25. http://dx.doi.org/10.1016/j.cplett.2005.04.008.

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Riddell, Frank G., Martin Rogerson, Ferenc Fülöp, and Gábor Bernáth. "Solid-state NMR study of the kinetics of a ring chain tautomerism in a tetrahydro-1, 3-oxazine derivative." Magnetic Resonance in Chemistry 33, no. 7 (1995): 600–602. http://dx.doi.org/10.1002/mrc.1260330719.

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