Academic literature on the topic 'Oxazole derivative'

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Journal articles on the topic "Oxazole derivative"

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Garg, Ajay Kumar, Ranjan Kumar Singh, Vaibhav Saxena, Saurabh Kr Sinha, and Sanjay Rao. "Synthesis, Characterization, and Anti-inflammatory activity of Some Novel Oxazole Derivatives." Journal of Drug Delivery and Therapeutics 13, no. 1 (2023): 26–28. http://dx.doi.org/10.22270/jddt.v13i1.5719.

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A series of novel oxazole derivatives (A, A1, A2) were synthesized starting from acetone and urea. The compound (A) was obtained by heating it with acetophenone and urea in iodine. Compound (A) on treatment with 4-amino benzaldehyde (Z)-N-(4-amino benzylidine)-4-((E)-Penta-2, 4-diene-2) oxazole-2-amine afforded (A1). Acylation of compound (A) with 4-amino benzoyl chloride to obtain the corresponding N-(4 phenyl oxazole-2- yl)- benzamide (A2). The structures of compounds have been established employing FTIR and 1H-NMR spectral analysis. All oxazole derivatives were evaluated for anti-inflammato
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Kotha, Sambasivarao, and Subba Rao Cheekatla. "Synthesis of Bisoxazole and Bromo-substituted Aryloxazoles." Molbank 2022, no. 3 (2022): M1440. http://dx.doi.org/10.3390/m1440.

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Herein, we report a bisoxazole derivative as well as a bromo-substituted oxazole derivatives via a simple approach. The synthesis begins with an inexpensive and readily available starting material, such as 2,5-dimethoxybenzaldehyde, hydroquinone, and p-toluenesulfonylmethyl isocyanide (TosMIC). This approach relies on the Van Leusen oxazole method and electrophilic aromatic bromination. The structures of bisoxazole and bromosubstituted aryloxazoles were fully supported by spectroscopic methods (IR, NMR, and HRMS) and further established using single crystal X-ray diffraction studies.
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Kateryna, Matskevych. "Research of 1,3-oxazole-4-il-phosphonic acid derivative on the content of fatty acids of lipids in rats with arterial hypertension." ScienceRise: Pharmaceutical Science, no. 4(14) (August 31, 2018): 28–31. https://doi.org/10.15587/2519-4852.2018.141411.

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The number of patients with arterial hypertension (AH) continues to increase. Significant negative effects of arterial hypertension are structural, metabolic and functional disorders in the tissues of the myocardium, vessels and other organs, in particular, changes in the content of fatty acids (FA) and their correlation. The purpose of the study is to investigate the change in fatty acid composition of lipids in blood serum and tissues of rats with arterial hypertension under the influence of a new original compound, 1,3-oxazole-4-yl-phosphonic acid derivative (abbreviated name - oxazole deri
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Mistry, Rakesh N., and K. R. Desai. "Studies on Synthesis of Some Novel Heterocyclic Azlactone Derivatives and Imidazolinone Derivatives and their Antimicrobial Activity." E-Journal of Chemistry 2, no. 1 (2005): 42–51. http://dx.doi.org/10.1155/2005/542938.

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p- Methyl benzoic acid on reaction with phosphorus pentachloride gives p - methyl benzoyl chloride derivative which on condensation with glycine gives p - methyl benzoyl glycine derivative. Now, this p - methyl benzoyl glycine derivative on condensation with various substituted aldehydes gives corresponding substituted 4 - [aryl methylidine] - 2 - [p - methyl phenyl] - oxazole - 5 - one derivatives [1(a-j)]. Further, these derivatives [1(a-j)] on condensation with 4 , 4’ - diamino diphenyl sulphone gives corresponding substituted imidazolinone - dibenzsulphone derivatives [2(a-j)], on condensa
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Šagud, Ivana, Simona Božić, Željko Marinić, and Marija Šindler-Kulyk. "Photochemical approach to functionalized benzobicyclo[3.2.1]octene structures via fused oxazoline derivatives from 4- and 5-(o-vinylstyryl)oxazoles." Beilstein Journal of Organic Chemistry 10 (September 18, 2014): 2222–29. http://dx.doi.org/10.3762/bjoc.10.230.

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Novel cis/trans-4- and cis/trans-5-(2-vinylstyryl)oxazoles have been synthesized by Wittig reactions from the diphosphonium salt of α,α’-o-xylene dibromide, formaldehyde and 4- and 5-oxazolecarbaldehydes, respectively. In contrast, trans-5-(2-vinylstyryl)oxazole has been synthesized by the van Leusen reaction from trans-3-(2-vinylphenyl)acrylaldehyde which is prepared from o-vinylbenzaldehyde and (formylmethylene)triphenylphosphorane. The 4- and 5-(2-vinylstyryl)oxazoles afford, by photochemical intramolecular cycloaddition, diverse fused oxazoline-benzobicyclo[3.2.1]octadienes, which are iden
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Kenari, Marziyeh E., Joshua I. Putman, Ravi P. Singh, et al. "Enantiomeric Separation of New Chiral Azole Compounds." Molecules 26, no. 1 (2021): 213. http://dx.doi.org/10.3390/molecules26010213.

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Twelve new azole compounds were synthesized through an ene reaction involving methylidene heterocycles and phenylmaleimide, producing four oxazoles, five thiazoles, and one pyridine derivative, and ethyl glyoxylate for an oxazole and a thiazole compound. The twelve azoles have a stereogenic center in their structure. Hence, a method to separate the enantiomeric pairs, must be provided if any further study of chemical and pharmacological importance of these compounds is to be accomplished. Six chiral stationary phases were assayed: four were based on macrocyclic glycopeptide selectors and two o
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Stockert, Juan C. "Notes: Fluorescence of Chromatin DNA by an Oxazolium Scintillator." Zeitschrift für Naturforschung C 47, no. 5-6 (1992): 481–82. http://dx.doi.org/10.1515/znc-1992-0625.

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Aqueous solutions of a yellow and highly fluorescent derivative from dimethyl-POPOP, obtained by treating a chloroform solution of this oxazole scintillator with dimethylsulfate, induce a strong blue-green or yellowgreen fluorescence in chromatin DNA under ultraviolet (365 nm) or violet-blue (436 nm) excitation, respectively. It is suggested that this new and selective fluorescence reaction could originate from binding of the oxazolium derivative into the minor groove of DNA.
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Mcguire, Edward J., Robert H. Gray, and Felix A. De La Iglesia. "Chemical Structure-Activity Relationships: Peroxisome Proliferation and Lipid Regulation in Rats." Journal of the American College of Toxicology 11, no. 3 (1992): 353–61. http://dx.doi.org/10.3109/10915819209141875.

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Studies described here address structure-activity relationships of novel hypolipidemic agents that induce peroxisome proliferation. Male rats were given equivalent doses of three well-studied fibrates, fibrate amides, and structurally dissimilar agents. Aryloxyalkanoic acids, amide analogs, and thio, benzimidazole, phenylpiperazine, and oxazole derivatives induced peroxisome proliferation and decreased plasma cholesterol and triglyceride levels. These compounds contain an acidic function or appear to be readily metabolized to a derivative with an acidic function. Substitution of this substitue
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Venkatasubramanian H, Sarojkumar Sha, Hemalatha S, and Easwaramoorthy D. "Synthesis, characterization of new nicotinamide-oxazole analogs, and their antimicrobial activity." International Journal of Research in Pharmaceutical Sciences 11, no. 2 (2020): 2707–12. http://dx.doi.org/10.26452/ijrps.v11i2.2292.

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Identification of a novel antimicrobial molecule is vital to research due to contaminated agro related products and injurious pathogens. Especially candida albicans is most common infective fungi in the present world, that cause hospital-acquired infections. There is a medical and biological need for the discovery of novel antimicrobial drugs with high potent in nature. This effort involved the synthesis of scaffold molecule, in which Vitamin B3 and oxazole plays vital role as pharmacophore moiety, where 2-(Nicotinamido) oxazole-4-Carboxylic acid coupled from pyridine–3-carboxylic acid (Nicoti
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Heo, Yeongjae, Hyukmin Kwon, Sangwook Park, et al. "A High-Efficiency Deep Blue Emitter for OLEDs with a New Dual-Core Structure Incorporating ETL Characteristics." Molecules 28, no. 22 (2023): 7485. http://dx.doi.org/10.3390/molecules28227485.

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In this study, we introduced the weak electron-accepting oxazole derivative 4,5-diphenyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxazole (TPO) into both anthracene and pyrene moieties of a dual core structure. Ultimately, we developed 2-(4-(6-(anthracen-9-yl)pyren-1-yl)phenyl)-4,5-diphenyloxazole (AP-TPO) as the substitution on the second core, pyrene, and 4,5-diphenyl-2-(4-(10-(pyren-1-yl)anthracen-9-yl)phenyl)oxazole (TPO-AP) as the substitution on the first core, anthracene. Both materials exhibited maximum photoluminescence wavelengths at 433 and 443 nm in solution and emi
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Dissertations / Theses on the topic "Oxazole derivative"

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BARRECA, Marilia. "[1,2]OXAZOLE DERIVATIVES: SYNTHESIS AND BIOLOGICAL EVALUATION AGAINST MULTIPLE MALIGNANT CELL TYPES." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/497882.

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Pritchard, Martin David. "Investigations on the synthesis of new photochromic oxazine derivatives." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/11283.

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Initial studies were based on previous work at Edinburgh in which the reaction of the lithium salt of 1,2-naphthalenedione 1-oxime with 2-bromo-2,2-diphenylacetaldehyde was found to afford an oxime ether which was reduced with triphenylphosphine to afford 3,3-diphenyl-3<i>H</i>-naphth[2,1-<i>b</i>]-1, 4-oxazine. Similarly, 2,2-diphenyl-2<i>H</i>-naphth[1,2-<i>b</i>]-1,4-oxazine was prepared in a parallel synthetic strategy using 1,2-naphthalenedione 2-oxime as key starting material. To facilitate the expansion of this strategy, further bromo-aldehydes functionalised with variously substituted
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Rowe, David Martin. "Investigations of the synthesis of new photochromic oxazine and oxadiazine derivatives." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/12884.

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This thesis is concerned with the investigation of new synthetic routes to novel oxazine and oxadiazine derivatives which are of potential photochromic importance. A general synthetic strategy for the synthesis of 2,2-disubstituted 2H-benz-1,4-oxazines based on the synthesis of 2-nitrophenoxyacetaldehydes and their reductive cyclisation via a situ ring closure of intermediate 2-aminophenoxyacetaldehydes was investigated. Various attempts having failed to achieve the reductive cyclisation of the 2-nitrophenoxyacetaldehydes to the 2H-benz-1,4-oxazines, attention was turned to an alternative appr
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Laughton, Peter. "Synthesis of #beta#-carboxyaspartic acid derivatives and studies on 3-methoxycarbonylmethylene-3,4,5,6-tetrahydro- 2H-1,4-oxazine-2-one derivatives." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390088.

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Felsmann, Marika. "Clathratbildner vom Bis-1,3-azol-Typ." Doctoral thesis, Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola&quot, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:105-qucosa-26675.

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Gegenstand dieser Arbeit ist die Synthese und Charakterisierung von Bis-1,3-azol-Derivaten insbesondere im Hinblick auf ihre potentielle Einsatzfähigkeit als chemisches Sensormaterial. Nach bereits bekannten Methoden gelang es, zehn neue Bisoxazol-Derivate sowie zehn neue Dicarbonsäurediester herzustellen. Weiterhin wurden 13 neue Bisimidazol- und vier neue Lophin-Derivate synthetisiert. Die erhaltenen Röntgeneinkristallstrukturanalysen zeigen, dass vor allem lineare Bisimidazol- und Bisoxazol-Derivate gute Eigenschaften als Clathratbildner aufweisen. Die Bisoxazol-Derivate mit Pyridin als Spa
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Felsmann, Marika. "Clathratbildner vom Bis-1,3-azol-Typ: Synthese, Komplexierung und sensorisch nutzbares Fluoreszenzverhalten." Doctoral thesis, TU Bergakademie Freiberg, 2009. https://tubaf.qucosa.de/id/qucosa%3A22698.

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Gegenstand dieser Arbeit ist die Synthese und Charakterisierung von Bis-1,3-azol-Derivaten insbesondere im Hinblick auf ihre potentielle Einsatzfähigkeit als chemisches Sensormaterial. Nach bereits bekannten Methoden gelang es, zehn neue Bisoxazol-Derivate sowie zehn neue Dicarbonsäurediester herzustellen. Weiterhin wurden 13 neue Bisimidazol- und vier neue Lophin-Derivate synthetisiert. Die erhaltenen Röntgeneinkristallstrukturanalysen zeigen, dass vor allem lineare Bisimidazol- und Bisoxazol-Derivate gute Eigenschaften als Clathratbildner aufweisen. Die Bisoxazol-Derivate mit Pyridin als Spa
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Viswanathan, Subha. "Nitro- and oxazoline-derivatized antennas structural and photophysical characterization of their lanthanide complexes /." Related electronic resource:, 2007. http://proquest.umi.com/pqdweb?did=1362530571&sid=2&Fmt=2&clientId=3739&RQT=309&VName=PQD.

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Tauhardt, Lutz Verfasser], Ulrich Sigmar [Akademischer Betreuer] [Schubert, and Dagmar [Akademischer Betreuer] Fischer. "Poly(2-oxazoline)s and their derivatives : a versatile polymer class with manifold application possibilities / Lutz Tauhardt. Gutachter: Ulrich Sigmar Schubert ; Dagmar Fischer." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2015. http://d-nb.info/1067098801/34.

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Tauhardt, Lutz [Verfasser], Ulrich Sigmar [Akademischer Betreuer] Schubert, and Dagmar [Akademischer Betreuer] Fischer. "Poly(2-oxazoline)s and their derivatives : a versatile polymer class with manifold application possibilities / Lutz Tauhardt. Gutachter: Ulrich Sigmar Schubert ; Dagmar Fischer." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2015. http://d-nb.info/1067098801/34.

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Roy, Amélie. "Synthetic studies of the formation of oxazoles and isoxazoles from N-acetoacetyl derivatives, scope and limitations ; and Aqueous rhodium-catalyzed Heck-type coupling reactions between boronic acids and olefins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0021/MQ53366.pdf.

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Books on the topic "Oxazole derivative"

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Mehariya, Krunalkumar R. X-Ray Crystallographic Study of Novel Oxazole Derivatives. Anchor Academic Publishing. ein Imprint der Diplomica Verlag GmbH, 2016.

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Roy, Amelie. Synthetic studies of the formation of oxazoles and isoxazoles from N-acetoacetyl derivatives: Scope and limitations AND Aqueous rhodium-catalyzed Heck-type coupling reactions between boronic acids and olefins. 2000.

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Book chapters on the topic "Oxazole derivative"

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Knight, David W. "Oxazole and Its Derivatives." In Heterocycles in Natural Product Synthesis. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634880.ch12.

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Gujjarappa, Raghuram, Sattu Sravani, Arup K. Kabi, et al. "An Overview on Biological Activities of Oxazole, Isoxazoles and 1,2,4-Oxadiazoles Derivatives." In Materials Horizons: From Nature to Nanomaterials. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8399-2_10.

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Posokhov, Yevgen O., Alexander Kyrychenko, and Yevgen Korniyenko. "Derivatives of 2,5-Diaryl-1,3-Oxazole and 2,5-Diaryl-1,3,4-Oxadiazole as Environment-Sensitive Fluorescent Probes for Studies of Biological Membranes." In Reviews in Fluorescence 2017. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-01569-5_9.

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Hiremath, P. B., K. Kantharaju, and S. H. Pattanashetty. "Microwave-assisted Synthesis of 4-Benzylidene-2-(2-fluorophenyl) Oxazol-5(4H)-one Derivatives Catalysed by Egg Shell Powder and Evaluation of Their Anti-microbial Activity." In Special Publications. Royal Society of Chemistry, 2019. http://dx.doi.org/10.1039/9781839160783-00123.

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Davies, David T. "Answers to problems." In Aromatic Heterocyclic Chemistry. Oxford University Press, 1992. http://dx.doi.org/10.1093/hesc/9780198556602.003.0011.

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This chapter presents the answers to the problems included in the previous chapters. Reaction of diketone with aminoketone produces enamine, which is not isolated, but cyclinizes directly to give pyrrole. Meanwhile, the application of generalised oxazole retrosynthesis leads to a simple glycine derivative. The mechanism of the oxazole formation is identical to that of the Hantzch thiazole synthesis. However, because of the reduced nucleophilicity of a carbonyl group as compared to a thiocarbonyl, this synthesis only proceeds under vigorous conditions. The alternative sequence would give a posi
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Chetia, Saurabh, Lalremruati, Brilliant N. Marak, and Ved Prakash Singh. "Chemistry and Pharmacological Applications of 1,3-Oxazoles." In Advances in Chemical and Materials Engineering. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-7267-8.ch001.

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Oxazoles, a class of five-membered aromatic heterocycles containing nitrogen and oxygen atoms, are of significant importance across various fields, including medicine and agriculture. Renowned for their diverse biological activities, including antibacterial, antiviral, anticancer, and anti-inflammatory properties, oxazoles have garnered significant attention in research. This chapter offers a comprehensive overview of the chemical properties, synthesis methods, and reactivity of oxazoles, alongside their pharmacological applications. It covers both conventional and forefront synthetic pathways
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Keertika, Bentham Science Publisher, and Nutan Sharma. "Oxazole, Oxadiazole, Isoxazoline and Oxazoline Derivatives as Anti-Inflammatory Agents." In Heterocyclic Anti-Inflammatory Agents: A Guide for Medicinal Chemists. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815223460124010007.

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Oxygen and Nitrogen containing five-membered heterocyclic compounds have been the target of intense investigation in the last two decades to discover potent biologically active compounds as anti-inflammatory agents. The related studies comprising of fascinating oxazole-based derivatives include oxazoles, isoxazoles, oxazolines, and oxadiazoles, as therapeutic agents, which have become an interesting topic.Therefore, noticeable achievements have been accomplished in the field of antiinflammatory studies. This chapter will discuss some latest updates on the synthesis and anti-inflammatory studie
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Kantlehner, W. "Synthesis from Oxazoles or Isoxazolium Salts." In Three Carbon-Heteroatom Bonds: Ketenes and Derivatives. Georg Thieme Verlag KG, 2006. http://dx.doi.org/10.1055/sos-sd-024-00445.

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Prashanth, G. K., Srilatha Rao, H. S. Lalithamba, et al. "Benzoxazoles." In Advances in Chemical and Materials Engineering. IGI Global, 2025. https://doi.org/10.4018/979-8-3693-7267-8.ch008.

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Benzoxazoles are heterocyclic compounds featuring a benzene ring fused to an oxazole ring. They have attracted significant attention in medicinal chemistry due to their diverse biological activities. Many pharmacological compounds have a core structure called a heterocyclic scaffold, which is essential to their therapeutic actions. Modest alterations to this fundamental structure may result in notable variations in the medication's mechanism of action. Benzoxazole and its derivatives have shown substantial and noteworthy therapeutic effects. This chapter explores the synthesis, structural char
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Kantlehner, W. "Synthesis from Oxazoles and Their Derivatives and Isocyanates." In Three Carbon-Heteroatom Bonds: Ketenes and Derivatives. Georg Thieme Verlag KG, 2006. http://dx.doi.org/10.1055/sos-sd-024-00401.

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Conference papers on the topic "Oxazole derivative"

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Putri, Chantika Octaviani, and Antonius Herry Cahyana. "Synthesis and antioxidant activity screening of thiazole and oxazole derivative compounds." In INTERNATIONAL CONFERENCE ON SCIENCE AND APPLIED SCIENCE (ICSAS) 2021. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0072502.

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Douhal, A., F. Lahmani, A. Zehnacker-Rentien та F. Amat-Guerri. "Ultrafast excited-state H-atom transfer in jet-cooled 2-(2ʹ-hydroxyphenyl)-oxazole derivatives". У The 54th international meeting of physical chemistry: Fast elementary processes in chemical and biological systems. AIP, 1996. http://dx.doi.org/10.1063/1.50150.

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Oliveira, Alfredo R. Marques, and Murilo B. Marcondes de Mello. "Study of photo-degradation of new 2-oxazoline telluride derivative." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0335-1.

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Eliwi, Amjad Gali, Zainab Zuhair Mohammad Ali, Fouad A. AL-Saady, Shaemaa Hadi Abdulsada, and Abdul Jabar Khlaf Atia. "Synthesis and acetyl cholinesterase inhibitory activity of new oxazole, 1, 2, 4 - triazole derivatives bearing carbamazepine as nucleus." In 2ND INTERNATIONAL CONFERENCE ON MATERIALS ENGINEERING & SCIENCE (IConMEAS 2019). AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0000455.

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Abdul-Amir, R. M., F. S. Al-Fartusie, and A. K. Atia. "Synthesis, anti-inflammatory and study of histological changes in the mice liver of 1,3-oxazole and 3,3-dihydro pyrazole derivatives." In 2ND INTERNATIONAL CONFERENCE OF MATHEMATICS, APPLIED SCIENCES, INFORMATION AND COMMUNICATION TECHNOLOGY. AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0161601.

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Guillon, Jean, François Hallé, Solène Savrimoutou, Stéphane Moreau, Daniel-Henri Caignard, and Pascal Sonnet. "Synthesis and Evaluation of New 6-formyl-oxazolo[3,2-a]pyrimidine derivatives as Potential Src Kinase Inhibitors." In 4th International Electronic Conference on Medicinal Chemistry. MDPI, 2018. http://dx.doi.org/10.3390/ecmc-4-05566.

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Ananthula, S., P. Parajuli, FA Behery, et al. "Abstract P3-03-11: Oxazine derivatives of g- and D- tocotrienols display potent anticancer effects in vivo." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-p3-03-11.

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Wang, Lei, Connor W. Barth, Jason R. Combs, Antonio R. Montaño, and Summer L. Gibbs. "Investigation of oxazine and rhodamine derivatives as peripheral Nerve tissue targeting contrast agent for in vivo fluorescence imaging." In Molecular-Guided Surgery: Molecules, Devices, and Applications V, edited by Brian W. Pogue and Sylvain Gioux. SPIE, 2019. http://dx.doi.org/10.1117/12.2507296.

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