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1

P., N. GUPTA, and RAINA ANJU. "Electrochemical Synthesis of Benzylacetamide by Oxidation of Phenylacetic Acid." Journal of Indian Chemical Society Vol. 66, Feb 1989 (1989): 95–97. https://doi.org/10.5281/zenodo.6303116.

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Department of Chemistry, University of Kashmir, Srinagar 190 006 <em>Manuscript&nbsp;received 18 June 1988, revised 19 October 1988, accepted 13 October 1988</em> Electrochemical oxidation or phenylacetlic acid to benzylacetamide on carbon anode in nominally wet acetonitrlle has been&nbsp;round to give 68% yield. The effect of potential, pH and temperature on&nbsp;the reaction&nbsp;revealed interesting features which throw light on the proposed mechanism.
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2

Panoutsopoulos, Georgios I. "Phenylacetaldehyde Oxidation by Freshly Prepared and Cryopreserved Guinea Pig Liver Slices: The Role of Aldehyde Oxidase." International Journal of Toxicology 24, no. 2 (2005): 103–9. http://dx.doi.org/10.1080/10915810590936373.

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Phenylacetaldehyde is formed when the xenobiotic and biogenic amine 2-phenylethylamine is inactivated by a monoamine oxidase–catalyzed oxidative deamination. Exogenous phenylacetaldehyde is found in certain foodstuffs such as honey, cheese, tomatoes, and wines. 2-Phenylethylamine can trigger migraine attacks in susceptible individuals and can become fairly toxic at high intakes from foods. It may also function as a potentiator that enhances the toxicity of histamine and tyramine. The present investigation examines the metabolism of phenylacetaldehyde to phenylacetic acid in freshly prepared an
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3

P., N. GUPTA, and RAINA ANJU. "Electrochemical Synthesis of Benzylacetamide by Oxidation of Phenylacetic Acid." Journal of Indian Chemical Society Vol. 66, February 1989 (1989): 95–97. https://doi.org/10.5281/zenodo.5948631.

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Department of Chemistry, University of Kashmir, Srinagar 190 006<strong><em> </em></strong> <em>Manuscript received 13 June 1988, revised 19 October 1988. accepted 13 October 1988</em> <strong>Electrochemical oxidation of phenylacetic acid to benzylacetamide on carbon </strong><strong>anode in nominally wet acetonitrile has been found to give 68% yield. The effect of </strong><strong>potential, pH and temperature on the reaction revealed interesting features which throw light on the proposed mechanism.</strong> &nbsp;
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4

Balkis, Ali, and Anthony P. O'Mullane. "Electrochemical Restructuring of Copper Surfaces Using Organic Additives and Its Effect on the Electrocatalytic Reduction of Nitrate Ions." Australian Journal of Chemistry 68, no. 8 (2015): 1213. http://dx.doi.org/10.1071/ch15191.

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This work describes the fabrication of nanostructured copper electrodes using a simple potential cycling protocol that involves oxidation and reduction of the surface in an alkaline solution. It was found that the inclusion of additives, such as benzyl alcohol and phenylacetic acid, has a profound effect on the surface oxidation process and the subsequent reduction of these oxides. This results in not only a morphology change, but also affects the electrocatalytic performance of the electrode for the reduction of nitrate ions. In all cases, the electrocatalytic performance of the restructured
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5

Pritzkow, Wilhelm, Volkmar Voerckel, and Heike Weber. "Synthesis of Phenylacetic Acid by Oxidation of Phenyl Acetaldehyde with Molecular Oxygen." Journal f�r Praktische Chemie/Chemiker-Zeitung 335, no. 8 (1993): 705–7. http://dx.doi.org/10.1002/prac.19933350810.

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6

Koetsier, Martijn J., Peter A. Jekel, Marco A. van den Berg, Roel A. L. Bovenberg, and Dick B. Janssen. "Characterization of a phenylacetate–CoA ligase from Penicillium chrysogenum." Biochemical Journal 417, no. 2 (2008): 467–76. http://dx.doi.org/10.1042/bj20081257.

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Enzymatic activation of PAA (phenylacetic acid) to phenylacetyl-CoA is an important step in the biosynthesis of the β-lactam antibiotic penicillin G by the fungus Penicillium chrysogenum. CoA esters of PAA and POA (phenoxyacetic acid) act as acyl donors in the exchange of the aminoadipyl side chain of isopenicillin N to produce penicillin G or penicillin V. The phl gene, encoding a PCL (phenylacetate–CoA ligase), was cloned in Escherichia coli as a maltose-binding protein fusion and the biochemical properties of the enzyme were characterized. The recombinant fusion protein converted PAA into p
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7

Kodumuri, Srujana, Swamy Peraka, Naresh Mameda, Durgaiah Chevella, Rammurthy Banothu, and Narender Nama. "Metal-free, catalytic regioselective oxidative conversion of vinylarenes: a mild approach to phenylacetic acid derivatives." RSC Advances 6, no. 8 (2016): 6719–23. http://dx.doi.org/10.1039/c5ra25296b.

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8

Zhang, Xiaolai. "Oxidations of Benzhydrazide and Phenylacetic Hydrazide by Hexachloroiridate(IV): Reaction Mechanism and Structure–Reactivity Relationship." Molecules 25, no. 2 (2020): 308. http://dx.doi.org/10.3390/molecules25020308.

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Benz(o)hydrazide (BH) is the basic aryl hydrazide; aryl hydrazides have been pursued in the course of drug discovery. Oxidations of BH and phenylacetic hydrazide (PAH) by hexachloroiridate(IV) ([IrCl6]2−) were investigated by use of stopped-flow spectral, rapid spectral scan, RP-HPLC and NMR spectroscopic techniques. The oxidation reactions followed well-defined second-order kinetics and the observed second-order rate constant k′ versus pH profiles were established over a wide pH range. Product analysis revealed that BH and PAH were cleanly oxidized to benzoic acid and phenylacetic acid, respe
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9

Somers, E., D. Ptacek, P. Gysegom, M. Srinivasan, and J. Vanderleyden. "Azospirillum brasilense Produces the Auxin-Like Phenylacetic Acid by Using the Key Enzyme for Indole-3-Acetic Acid Biosynthesis." Applied and Environmental Microbiology 71, no. 4 (2005): 1803–10. http://dx.doi.org/10.1128/aem.71.4.1803-1810.2005.

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ABSTRACT An antimicrobial compound was isolated from Azospirillum brasilense culture extracts by high-performance liquid chromatography and further identified by gas chromatography-mass spectrometry as the auxin-like molecule, phenylacetic acid (PAA). PAA synthesis was found to be mediated by the indole-3-pyruvate decarboxylase, previously identified as a key enzyme in indole-3-acetic acid (IAA) production in A. brasilense. In minimal growth medium, PAA biosynthesis by A. brasilense was only observed in the presence of phenylalanine (or precursors thereof). This observation suggests deaminatio
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10

Long, M. T., B. A. Bartholomew, M. J. Smith, P. W. Trudgill, and D. J. Hopper. "Enzymology of oxidation of tropic acid to phenylacetic acid in metabolism of atropine by Pseudomonas sp. strain AT3." Journal of bacteriology 179, no. 4 (1997): 1044–50. http://dx.doi.org/10.1128/jb.179.4.1044-1050.1997.

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11

Nierop Groot, Masja N., and Jan A. M. de Bont. "Conversion of Phenylalanine to Benzaldehyde Initiated by an Aminotransferase in Lactobacillus plantarum." Applied and Environmental Microbiology 64, no. 8 (1998): 3009–13. http://dx.doi.org/10.1128/aem.64.8.3009-3013.1998.

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ABSTRACT The production of benzaldehyde from phenylalanine has been studied in various microorganisms, and several metabolic pathways have been proposed in the literature for the formation of this aromatic flavor compound. In this study, we describe benzaldehyde formation from phenylalanine by using a cell extract of Lactobacillus plantarum. Phenylalanine was initially converted to phenylpyruvic acid by an aminotransferase in the cell extract, and the keto acid was further transformed to benzaldehyde. However, control experiments with boiled cell extract revealed that the subsequent conversion
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12

Lechner, Robert, Susanne Kümmel, and Burkhard König. "Visible light flavin photo-oxidation of methylbenzenes, styrenes and phenylacetic acids." Photochemical & Photobiological Sciences 9, no. 10 (2010): 1367. http://dx.doi.org/10.1039/c0pp00202j.

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13

Lapadatescu, Carmen, Christian Giniès, Jean-Luc Le Quéré, and Pascal Bonnarme. "Novel Scheme for Biosynthesis of Aryl Metabolites from l-Phenylalanine in the FungusBjerkandera adusta." Applied and Environmental Microbiology 66, no. 4 (2000): 1517–22. http://dx.doi.org/10.1128/aem.66.4.1517-1522.2000.

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ABSTRACT Aryl metabolite biosynthesis was studied in the white rot fungusBjerkandera adusta cultivated in a liquid medium supplemented with l-phenylalanine. Aromatic compounds were analyzed by gas chromatography-mass spectrometry following addition of labelled precursors (14C- and 13C-labelledl-phenylalanine), which did not interfere with fungal metabolism. The major aromatic compounds identified were benzyl alcohol, benzaldehyde (bitter almond aroma), and benzoic acid. Hydroxy- and methoxybenzylic compounds (alcohols, aldehydes, and acids) were also found in fungal cultures. Intracellular enz
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14

Matsuo, Hirotaka, Yoshihiko Noguchi, Rei Miyano, et al. "Thioporidiols A and B: Two New Sulfur Compounds Discovered by Molybdenum-Catalyzed Oxidation Screening from Trichoderma polypori FKI-7382." Antibiotics 9, no. 5 (2020): 236. http://dx.doi.org/10.3390/antibiotics9050236.

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Two new sulfur compounds, designated thioporidiol A (1) and B (2), were discovered by the MoS-screening program from a culture broth of Trichoderma polypori FKI-7382. The structures of 1 and 2 were determined as C13 lipid structures with an N-acetylcysteine moiety. The relative configuration at the C-5 and C-6 position of 1 was determined by the derivatives of α-methoxy-α-phenylacetic acid diesters, and the absolute configuration of the N-acetylcysteine moiety was determined by advanced Marfey’s analysis. Compounds 1 and 2 were evaluated for anti-microbial, cytotoxic and anti-malarial activiti
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15

Itoh, Akichika, Tomohiro Kodama, Shinji Inagaki та Yukio Masaki. "Oxidative Photodecarboxylation of α-Hydroxycarboxylic Acids and Phenylacetic Acid Derivatives with FSM-16". Organic Letters 2, № 3 (2000): 331–33. http://dx.doi.org/10.1021/ol991284z.

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16

Audi, Said H., Christopher A. Dawson, Susan B. Ahlf, and David L. Roerig. "Oxygen dependency of monoamine oxidase activity in the intact lung." American Journal of Physiology-Lung Cellular and Molecular Physiology 281, no. 4 (2001): L969—L981. http://dx.doi.org/10.1152/ajplung.2001.281.4.l969.

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Hydrogen peroxide generated by monoamine oxidase (MAO)-mediated deamination of biogenic amines has been implicated in cell signaling and oxidative injury. Because the pulmonary endothelium is a site of metabolism of monoamines present in the venous return, this brings into question a role for MAO in hyperoxic lung injury. The objective of this study was to evaluate the O2 dependency of the MAO reaction in the lung. To this end, we measured the pulmonary venous effluent concentrations of the MAO substrate [14C]phenylethylamine and its metabolite [14C]phenylacetic acid after the bolus injection
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17

Mąkosza, Mieczysław, Krystyna Kamieńska-Trela, Maciej Paszewski, and Małgorzata Bechcicka. "Oxidative nucleophilic substitution of hydrogen in nitroarenes with phenylacetic acid derivatives." Tetrahedron 61, no. 50 (2005): 11952–64. http://dx.doi.org/10.1016/j.tet.2005.09.053.

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18

Fu, Xuan, Megan Jamison, Aaron M. Jubb, et al. "Effect of copper salts on hydrothermal oxidative decarboxylation: a study of phenylacetic acid." Chemical Communications 56, no. 18 (2020): 2791–94. http://dx.doi.org/10.1039/c9cc09825a.

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19

Wang, Jun, Zhi Yong Chen, Mei Ping Zhao, and Yuan Zong Li. "Catalytical oxidation of styrene by molecularly imprinted polymer with phenylacetic acid as template and hemin as co-monomer." Chinese Chemical Letters 18, no. 8 (2007): 981–84. http://dx.doi.org/10.1016/j.cclet.2007.06.009.

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20

Itoh, Akichika, Tomohiro Kodama, Shinji Inagaki та Yukio Masaki. "ChemInform Abstract: Oxidative Photodecarboxylation of α-Hydroxycarboxylic Acids and Phenylacetic Acid Derivatives with FSM-16." ChemInform 31, № 19 (2010): no. http://dx.doi.org/10.1002/chin.200019063.

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21

Gandolfi, Raffaella, Kristin Cavenago, Roberto Gualandris, Josè Vicente Sinisterra Gago, and Francesco Molinari. "Production of 2-phenylacetic acid and phenylacetaldehyde by oxidation of 2-phenylethanol with free immobilized cells of Acetobacter aceti." Process Biochemistry 39, no. 6 (2004): 749–53. http://dx.doi.org/10.1016/s0032-9592(03)00185-7.

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22

Jain, Jitendra K., and Sampatraj B. Chandalia. "Production of phenylacetic acid by the liquid phase oxidation of acetophenone with sulphur in the presence of aqueous ammonia." Journal of Applied Chemistry and Biotechnology 24, no. 3 (2007): 105–12. http://dx.doi.org/10.1002/jctb.2720240302.

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23

Hussain, Farhaz Liaquat, Mrinaly Suri, Ashutosh Namdeo, et al. "A mild aerobic oxidation of benzyl alcohols and oxidative decarboxylation of phenylacetic acids by cellulose-supported Ag-Ag2S nanoparticles." Catalysis Communications 124 (May 2019): 76–80. http://dx.doi.org/10.1016/j.catcom.2019.01.011.

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24

Wang, Cheng, Guangzhen Zhou, Yanhua Xu та Peng Yu. "The Effect of Magnetic Composites (γ-Al2O3/TiO2/γ-Fe2O3) as Ozone Catalysts in Wastewater Treatment". Materials 15, № 23 (2022): 8459. http://dx.doi.org/10.3390/ma15238459.

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Using municipal sewage as a source of reclaimed water is an important way to alleviate the shortage of water resources. At present, advanced oxidation technology (AOPs), represented by ozone oxidation, is widely used in wastewater treatment. In this study, γ-Al2O3, a low-cost traditional ozone catalyst, was selected as the matrix. By modifying magnetic γ-Fe2O3 with a titanate coupling agent, in situ deposition, and calcination, the final formation of a γ-Al2O3/TiO2/γ-Fe2O3 micrometer ozone catalyst was achieved. A variety of material characterization methods were used to demonstrate that the r
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25

Yip, Karen Choi-Wan, and Ji-Dong GU Gu. "A novel bacterium involved in the degradation of 2-methylindole isolated from sediment of Inner Deep Bay of Hong Kong." Applied Environmental Biotechnology 1, no. 1 (2015): 52. http://dx.doi.org/10.18063/aeb.2016.01.008.

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A bacterial strain, designated as MPKc, was isolated from the mudflat sediment of Mai Po Inner Deep Bay of Hong Kong Mai Po Nature Reserve by enrichment culturing with 2-methylindole as the sole source of carbon and energy. The microorganism was a Gram-negative, rod-shaped (0.4–0.6 μm × 1.0–2.2 μm) and aerobic bacterium. Phylogenetic analysis based on the 16S rRNA gene sequences indicated that strain MPKc should be assigned as a novel bacterium, at least, at the species level. The 16S rDNA sequence most similiar to that of strain MPKc was Azoarcus evansii (94%) from available 16S rDNA sequence
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26

Baranov, Denis S., Anna S. Kashnik, Anastasiya N. Atnyukova, and Sergei A. Dzuba. "Spin-Labeled Diclofenac: Synthesis and Interaction with Lipid Membranes." Molecules 28, no. 16 (2023): 5991. http://dx.doi.org/10.3390/molecules28165991.

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Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) from the group of phenylacetic acid derivatives, which has analgesic, anti-inflammatory and antipyretic properties. The interaction of non-steroidal anti-inflammatory drugs with cell membranes can affect their physicochemical properties, which, in turn, can cause a number of side effects in the use of these drugs. Electron paramagnetic resonance (EPR) spectroscopy could be used to study the interaction of diclofenac with a membrane, if its spin-labeled analogs existed. This paper describes the synthesis of spin-labeled diclofenac (di
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27

Panoutsopoulos, Georgios I., Demetrios Kouretas, Elias G. Gounaris, and Christine Beedham. "Enzymatic Oxidation of 2-Phenylethylamine to Phenylacetic Acid and 2-Phenylethanol with Special Reference to the Metabolism of its Intermediate Phenylacetaldehyde." Basic Clinical Pharmacology Toxicology 95, no. 6 (2004): 273–79. http://dx.doi.org/10.1111/j.1742-7843.2004.t01-1-pto950505.x.

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28

Law, Robyn J., Jason N. R. Hamlin, Aida Sivro, Stuart J. McCorrister, Georgina A. Cardama, and Silvia T. Cardona. "A Functional Phenylacetic Acid Catabolic Pathway Is Required for Full Pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans Host Model." Journal of Bacteriology 190, no. 21 (2008): 7209–18. http://dx.doi.org/10.1128/jb.00481-08.

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ABSTRACT Burkholderia cenocepacia is a member of the Burkholderia cepacia complex, a group of metabolically versatile bacteria that have emerged as opportunistic pathogens in cystic fibrosis and immunocompromised patients. Previously a screen of transposon mutants in a rat pulmonary infection model identified an attenuated mutant with an insertion in paaE, a gene related to the phenylacetic acid (PA) catabolic pathway. In this study, we characterized gene clusters involved in the PA degradation pathway of B. cenocepacia K56-2 in relation to its pathogenicity in the Caenorhabditis elegans model
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29

I., Michael, Achilleos A., Lambropoulou D., et al. "Proposed transformation pathway and evolution profile of diclofenac and ibuprofen transformation products during (sono)photocatalysis." Applied Catalysis B: Environmental 147 (October 24, 2013): 1015–27. https://doi.org/10.1016/j.apcatb.2013.10.035.

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Liquid chromatography time-of-flight mass spectrometry (UPLC/ESI&ndash;QToF&ndash;MS) was used for the elucidation of the main transformation products (TPs) resulting from the degradation of diclofenac (DCF) and ibuprofen (IBP) during the application of various advanced oxidation processes in aqueous matrices. The examined processes were TiO<sub>2</sub> photocatalysis driven by UV-A or simulated solar irradiation, sonolysis, and UV-A photocatalysis integrated with ultrasound irradiation (sonophotocatalysis). A comparison between the applied treatment processes was performed with respect to the
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30

Valuparampil Varghese, Mathews, Joel James, Cody A. Eccles, Maki Niihori, Olga Rafikova, and Ruslan Rafikov. "Inhibition of Anaplerosis Attenuated Vascular Proliferation in Pulmonary Arterial Hypertension." Journal of Clinical Medicine 9, no. 2 (2020): 443. http://dx.doi.org/10.3390/jcm9020443.

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Vascular remodeling is considered a key event in the pathogenesis of pulmonary arterial hypertension (PAH). However, mechanisms of gaining the proliferative phenotype by pulmonary vascular cells are still unresolved. Due to well-established pyruvate dehydrogenase (PDH) deficiency in PAH pathogenesis, we hypothesized that the activation of another branch of pyruvate metabolism, anaplerosis, via pyruvate carboxylase (PC) could be a key contributor to the metabolic reprogramming of the vasculature. In sugen/hypoxic PAH rats, vascular proliferation was found to be accompanied by increased activati
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31

Liu, Y. Q., J. Han, P. N. Epstein та Y. S. Long. "Enhanced rat β-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway". American Journal of Physiology-Endocrinology and Metabolism 288, № 3 (2005): E471—E478. http://dx.doi.org/10.1152/ajpendo.00427.2004.

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Islet β-cell proliferation is a very important component of β-cell adaptation to insulin resistance and prevention of type 2 diabetes mellitus. However, we know little about the mechanisms of β-cell proliferation. We now investigate the relationship between pyruvate carboxylase (PC) pathway activity and islet cell proliferation 5 days after 60% pancreatectomy (Px). Islet cell number, protein, and DNA content, indicators of β-cell proliferation, were increased two- to threefold 5 days after Px. PC and pyruvate dehydrogenase (PDH) activities increased only ∼1.3-fold; however, islet pyruvate cont
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32

Williams, Renee T., Annika Caspers-Brown, Jennifer Michaud, et al. "Possible Missing Sources of Atmospheric Glyoxal Part II: Oxidation of Toluene Derived from the Primary Production of Marine Microorganisms." Metabolites 14, no. 11 (2024): 631. http://dx.doi.org/10.3390/metabo14110631.

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Background: Glyoxal has been implicated as a significant contributor to the formation of secondary organic aerosols, which play a key role in our ability to estimate the impact of aerosols on climate. Elevated concentrations of glyoxal over open ocean waters suggest that there exists an additional source, different from urban and forest environments, which has yet to be identified. Methods: Based on mass spectrometric analyses of nascent sea spray aerosols (SSAs) and gas-phase molecules generated during the course of a controlled algal bloom, the work herein suggests that marine microorganisms
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33

Hidalgo, Francisco J., and Rosario Zamora. "Formation of phenylacetic acid and benzaldehyde by degradation of phenylalanine in the presence of lipid hydroperoxides: New routes in the amino acid degradation pathways initiated by lipid oxidation products." Food Chemistry: X 2 (June 2019): 100037. http://dx.doi.org/10.1016/j.fochx.2019.100037.

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34

Ivon, Ye, V. Le, and Z. Voitenko. "SYNTHESIS OF PHENYLACETYL MIDA BORONATES BY OXIDATIVE CLEAVAGE OF VICINAL DIOLS." Bulletin of Taras Shevchenko National University of Kyiv. Chemistry, no. 1(55) (2018): 50–54. http://dx.doi.org/10.17721/1728-2209.2018.1(55).12.

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A synthetical approach to acyl(N-methyliminodiacetyl)boronates starting from 1-substituted alkenylboronates has been developed. A comparison of different methods of oxidative cleavage of an α-borylated C-C bound was made. It was found, that the best results can be obtained by sequential osmium tetroxide-catalyzed dihydroxylation of an alkene moiety followed by cleavage of the obtained vicinal diol. The cleavage procedure takes place at 0°C in homogeneous conditions (solution of periodic acid in THF) and it is complete in 10 minutes (more prolonged contact with an oxidant solution results in de
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35

Rodrı́guez-Sáiz, M., J. L. Barredo, M. A. Moreno, J. M. Fernández-Cañón, M. A. Peñalva, and B. Dı́ez. "Reduced Function of a Phenylacetate-Oxidizing Cytochrome P450 Caused Strong Genetic Improvement in Early Phylogeny of Penicillin-Producing Strains." Journal of Bacteriology 183, no. 19 (2001): 5465–71. http://dx.doi.org/10.1128/jb.183.19.5465-5471.2001.

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ABSTRACT The single-copy pahA gene from Penicillium chrysogenum encodes a phenylacetate 2-hydroxylase that catalyzes the first step of phenylacetate catabolism, an oxidative route that decreases the precursor availability for penicillin G biosynthesis. PahA protein is homologous to cytochrome P450 monooxygenases involved in the detoxification of xenobiotic compounds, with 84% identity to the Aspergillus nidulans homologue PhacA. Expression level of pahA displays an inverse correlation with the penicillin productivity of the strain and is subject to induction by phenylacetic acid. Gene expressi
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36

Flores, Rafael, Shoaib Iqbal, and Donald Sikazwe. "Phenylacetyl-/Trolox- Amides: Synthesis, Sigma-1, HDAC-6, and Antioxidant Activities." International Journal of Molecular Sciences 24, no. 20 (2023): 15295. http://dx.doi.org/10.3390/ijms242015295.

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In search of novel multi-mechanistic approaches for treating Alzheimer’s disease (AD), we have embarked on synthesizing single small molecules for probing contributory roles of the following combined disease targets: sigma-1 (σ-1), class IIb histone deacetylase-6 (HDAC-6), and oxidative stress (OS). Herein, we report the synthesis and partial evaluation of 20 amides (i.e., phenylacetic and Trolox or 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid derivatives). Target compounds were conveniently synthesized via amidation by either directly reacting acyl chlorides with amines or condensin
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37

Jana, Sirsendu, Arpan Kumar Maiti, Maria Bindu Bagh, et al. "Dopamine but not 3,4-dihydroxy phenylacetic acid (DOPAC) inhibits brain respiratory chain activity by autoxidation and mitochondria catalyzed oxidation to quinone products: Implications in Parkinson's disease." Brain Research 1139 (March 2007): 195–200. http://dx.doi.org/10.1016/j.brainres.2006.09.100.

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38

Jinkala, Rajesh, Shiva Kumar K. B., Venkateshwarlu Rapolu, et al. "Iodine promoted synthesis of pyrido[2′,1′:2,3]imidazo[4,5-c]quinoline derivatives via oxidative decarboxylation of phenylacetic acid." Synthetic Communications 52, no. 2 (2022): 258–67. http://dx.doi.org/10.1080/00397911.2021.2019278.

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39

Naveen, Kumar Vishven, Kandasamy Saravanakumar, Anbazhagan Sathiyaseelan, and Myeong-Hyeon Wang. "Comparative Analysis of the Antioxidant, Antidiabetic, Antibacterial, Cytoprotective Potential and Metabolite Profile of Two Endophytic Penicillium spp." Antioxidants 12, no. 2 (2023): 248. http://dx.doi.org/10.3390/antiox12020248.

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The current study assessed the metabolite abundance, alpha (α)-amylase and α-glucosidase inhibitory, antioxidant, and antibacterial activity of the ethyl acetate extract (EAE) of endophytic Penicillium lanosum (PL) and Penicillium radiatolobatum (PR). A higher extract yield was found in EAE-PR with a total phenolic content of 119.87 ± 3.74 mg of GAE/g DW and a total flavonoid content of 16.26 ± 1.95 mg of QE/g DW. The EAE-PR inhibited α-amylase and scavenged ABTS+ radicals with a half-maximal inhibitory concentration (IC50) of 362.5 and 37.5 µg/mL, respectively. Compared with EAE-PL, EAE-PR ex
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40

Sun, Yuhang, Yao Wu, Bing Fang, et al. "Comparative Analysis of Egg Yolk Phospholipid Unsaturation and Its Impact on Neural Health in Alzheimer Disease Mice." Foods 14, no. 5 (2025): 792. https://doi.org/10.3390/foods14050792.

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The mechanism of egg yolk phosphatidylcholine (PC) in alleviating Alzheimer’s disease (AD) has not yet been clear. The fatty acid composition of PC, especially the ratio of polyunsaturated fatty acids (PUFA), may be a critical determinant of their structural and functional roles. This study aimed to conduct a comparative analysis of the unsaturation levels of egg yolk PC and their impact on neurological health in a murine model of AD. The results showed that oral administration of high and low unsaturation PC (HUP, LUP) enhanced learning and memory abilities in AD mice, with the HUP interventi
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O'Leary, Niall D., Kevin E. O'Connor, Patrick Ward, Miriam Goff, and Alan D. W. Dobson. "Genetic Characterization of Accumulation of Polyhydroxyalkanoate from Styrene in Pseudomonas putida CA-3." Applied and Environmental Microbiology 71, no. 8 (2005): 4380–87. http://dx.doi.org/10.1128/aem.71.8.4380-4387.2005.

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ABSTRACT Pseudomonas putida CA-3 is capable of accumulating medium-chain-length polyhydroxyalkanoates (MCL-PHAs) when growing on the toxic pollutant styrene as the sole source of carbon and energy. In this study, we report on the molecular characterization of the metabolic pathways involved in this novel bioconversion. With a mini-Tn5 random mutagenesis approach, acetyl-coenzyme A (CoA) was identified as the end product of styrene metabolism in P. putida CA-3. Amplified flanking-region PCR was used to clone functionally expressed phenylacetyl-CoA catabolon genes upstream from the sty operon in
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Dharma Rao, Vutukuri, and Mariappan Periasamy. "Enantioselective synthesis of 2,3-diphenyl-1,4-butanediol via oxidative coupling of phenylacetic acid chiral 1,1′-bi-2-naphthyl ester using TiCl4/Et3N." Tetrahedron: Asymmetry 11, no. 5 (2000): 1151–55. http://dx.doi.org/10.1016/s0957-4166(00)00040-9.

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Nouri, Ali, and Esfandiar Heidarian. "Nephroprotective effect of silymarin against diclofenac induced renal damage and oxidative stress in male rats." Journal of Herbmed Pharmacology 8, no. 2 (2019): 146–52. http://dx.doi.org/10.15171/jhp.2019.23.

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Introduction: Diclofenac (DIC), a phenylacetic acid compound which belongs to nonsteroidal anti-inflammatory drugs (NSAIDs), is generally used for the treatment of various diseases such as rheumatoid arthritis, ankylosing spondylitis, acute muscle pain conditions and osteoarthritis. Overdose of DIC can lead to renal injuries in both experimental animal and human. Our research was done to assess the protective role of silymarin on renal damage induced by DIC in rats. Methods: Thirty-two Wistar rats were assigned to four groups (n=8/group). Group 1 was control group; animals in group 2 were admi
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Hodgson, D. J., and R. O. Asplund. "Phenylacetic acid." Acta Crystallographica Section C Crystal Structure Communications 47, no. 9 (1991): 1986–87. http://dx.doi.org/10.1107/s0108270191002275.

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Mohamed, Magdy El-Said, Annette Zaar, Christa Ebenau-Jehle, and Georg Fuchs. "Reinvestigation of a New Type of Aerobic Benzoate Metabolism in the Proteobacterium Azoarcus evansii." Journal of Bacteriology 183, no. 6 (2001): 1899–908. http://dx.doi.org/10.1128/jb.183.6.1899-1908.2001.

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ABSTRACT The aerobic metabolism of benzoate in the proteobacteriumAzoarcus evansii was reinvestigated. The known pathways leading to catechol or protocatechuate do not operate in this bacterium. The presumed degradation via 3-hydroxybenzoyl-coenzyme A (CoA) and gentisate could not be confirmed. The first committed step is the activation of benzoate to benzoyl-CoA by a specifically induced benzoate-CoA ligase (AMP forming). This enzyme was purified and shown to differ from an isoenzyme catalyzing the same reaction under anaerobic conditions. The second step postulated involves the hydroxylation
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Castillo, Aly, Maria Celeiro, Beatriz Martínez-Vallespín, et al. "In vivo tracking of grape marc biomarkers, bioconversion, metabolic tracers, and microbiota modulation in swine fed a polyphenol-rich extract diet." PLOS One 20, no. 6 (2025): e0325079. https://doi.org/10.1371/journal.pone.0325079.

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This work evaluated the addition of the polyphenol-rich bioactive extract “e-Vitis”, derived from grape marc (the main by-product of the wine industry), into swine feed. This was performed with the aim of testing the in vivo bioavailability of functional compounds, mainly phenolics, through the digestive system and excreta, together with the detection of bioconversion products associated with gut microbiota improvements. Additionally, the palatability of e-Vitis feed was evaluated, as well as the absence of metabolites that could compromise its innocuity. Through a pilot trial, a global method
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Abdulmalek, Emilia, Mahashanon Arumugam, Hanis Nabillah Mizan, Mohd Basyaruddin Abdul Rahman, Mahiran Basri, and Abu Bakar Salleh. "Chemoenzymatic Epoxidation of Alkenes and Reusability Study of the Phenylacetic Acid." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/756418.

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Here, we focused on a simple enzymatic epoxidation of alkenes using lipase and phenylacetic acid. The immobilisedCandida antarcticalipase B, Novozym 435 was used to catalyse the formation of peroxy acid instantly from hydrogen peroxide (H2O2) and phenylacetic acid. The peroxy phenylacetic acid generated was then utilised directly forin situoxidation of alkenes. A variety of alkenes were oxidised with this system, resulting in 75–99% yield of the respective epoxides. On the other hand, the phenylacetic acid was recovered from the reaction media and reused for more epoxidation. Interestingly, th
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KUBOTA, Terumasa, Yuji OKI, Hiroko UEHARA, and Yukari HARAMAKI. "Phenylacetic acid in vinegar." Journal of the agricultural chemical society of Japan 63, no. 1 (1989): 49–50. http://dx.doi.org/10.1271/nogeikagaku1924.63.49.

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Zhang, Huan, Qin Cheng, Xu Wang, et al. "Selenium Improved Phenylacetic Acid Content in Oilseed Rape and Thus Enhanced the Prevention of Sclerotinia sclerotiorum by Dimethachlon." Journal of Fungi 8, no. 11 (2022): 1193. http://dx.doi.org/10.3390/jof8111193.

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Sclerotinia sclerotiorum is a broad-spectrum necrotrophic phytopathogen that can infect many plant species worldwide. The application of fungicides is a common measure for controlling Sclerotinia sclerotiorum. Due to the risk of developing resistance to fungicides, it is imperative to find ways to be environmentally friendly and even effective. Using bioactive compounds in plants to reduce the amounts of fungicides has become a clean and sustainable strategy of controlling Sclerotinia sclerotiorum. Our study found that selenium in soil mediated the phenylacetic acid-related metabolic pathway i
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Yoshizako, Fumiki, Teruo Ueno, Isao Morishima, Tetsunobu Karakawa, Satoshi Sugiura, and Takaaki Araki. "The Formation of 2,6-Dihydroxy-phenylacetic Acid from Phenylacetic Acid by Various Fungi." Agricultural and Biological Chemistry 49, no. 3 (1985): 877–79. http://dx.doi.org/10.1080/00021369.1985.10866820.

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