Relevant bibliographies by topics / Oxidative Aging

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Oxidative Aging'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 February 2022

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Journal articles on the topic "Oxidative Aging"

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Neki, N. S. "Oxidative Stress and Aging." Bangladesh Journal of Medical Science 14, no. 3 (June 20, 2015): 221–27. http://dx.doi.org/10.3329/bjms.v14i3.23468.

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Ageing is an inevitable life process characterized by a gradual functional decline of all organ systems occurring at the cellular, tissue, organ and whole body levels further leading to the development of diseases and finally death. Although aging is a normal physiological process, it can be accelerated during oxidative stress or during chronic inflammatory conditions. An appropriate theory must explain four main characteristics of ageing: it is endogenous, progressive, irreversible and deleterious for the individual. Oxidative stress is caused by imbalance between oxidants and antioxidants. Reactive Oxygen Species (ROS) not only cause cell damage, but are also involved in intracellular signaling. ROS include superoxide (O2-), hydrogen peroxide (H2O2), hydroxyl radical (OH-) and peroxynitrite. Various enzyme systems produce ROS including the mitochondrial electron transport chain, cytochrome P450, lipoxygenase, cyclooxygenase, the NADPH oxidase complex, xanthine oxidase and peroxisomes. More research is needed to explain the exact mechanisms related to ageing and oxidative stress.Bangladesh Journal of Medical Science Vol.14(3) 2015 p.221-227
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Szarka, András, Gábor Bánhegyi, and Balázs Sümegi. "Mitochondria, oxidative stress and aging." Orvosi Hetilap 155, no. 12 (March 2014): 447–52. http://dx.doi.org/10.1556/oh.2014.29852.

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The free radical theory of aging was defined in the 1950s. On the base of this theory, the reactive oxygen species formed in the metabolic pathways can play pivotal role in ageing. The theory was modified by defining the mitochondrial respiration as the major cellular source of reactive oxygen species and got the new name mitochondrial theory of aging. Later on the existence of a “vicious cycle” was proposed, in which the reactive oxygen species formed in the mitochondrial respiration impair the mitochondrial DNA and its functions. The formation of reactive oxygen species are elevated due to mitochondrial dysfunction. The formation of mitochondrial DNA mutations can be accelerated by this “vicious cycle”, which can lead to accelerated aging. The exonuclease activity of DNA polymerase γ, the polymerase responsible for the replication of mitochondrial DNA was impaired in mtDNA mutator mouse recently. The rate of somatic mutations in mitochondrial DNA was elevated and an aging phenotype could have been observed in these mice. Surprisingly, no oxidative impairment neither elevated reactive oxygen species formation could have been observed in the mtDNA mutator mice, which may question the existence of the “vicious cycle”. Orv. Hetil., 2014, 155(12), 447–452.
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Rad, Farhad Yousefi, Michael D. Elwardany, Cassie Castorena, and Y. Richard Kim. "Evaluation of Chemical and Rheological Aging Indices to Track Oxidative Aging of Asphalt Mixtures." Transportation Research Record: Journal of the Transportation Research Board 2672, no. 28 (June 29, 2018): 349–58. http://dx.doi.org/10.1177/0361198118784138.

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Oxidative age hardening in asphalt binder leads to embrittlement. Embrittled asphalt is prone to fatigue and thermal cracking. Therefore, the ability to predict asphalt binder oxidative age hardening within a pavement throughout its service life could inform improved pavement material selection, design, and maintenance practices. Studying the evolution of oxidative aging requires the use of key properties to track oxidation levels, termed aging index properties (AIPs) here. The objective of this study is to identify suitable rheological and chemical AIPs to track oxidation levels in asphalt materials. A wide range of laboratory and field aged materials were evaluated in this study. A range of chemical AIPs determined by Fourier transform infrared spectroscopy (FTIR) absorbance peaks and areas were evaluated based on their correlation with laboratory aging duration. Rheological AIPs were evaluated based on the strength of their relationship to the chemical changes induced by oxidation. The rheological AIPs evaluated included the dynamic shear modulus, zero shear viscosity, Glover-Rowe parameter, and crossover modulus. The chemical AIP evaluation that most strongly correlated with laboratory aging duration is the carbonyl plus the sulfoxide absorbance peaks. The results indicate that both the dynamic shear modulus and Glover-Rowe parameter constitute rheological AIPs that relate directly to the chemical changes induced by oxidation.
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Haenold, Ronny, D. Mokhtar Wassef, Stefan H. Heinemann, and Toshinori Hoshi. "Oxidative damage, aging and anti-aging strategies." AGE 27, no. 3 (September 2005): 183–99. http://dx.doi.org/10.1007/s11357-005-2915-0.

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NIKI, Etsuo. "Oxidative Stress and Aging." Internal Medicine 39, no. 4 (2000): 324–26. http://dx.doi.org/10.2169/internalmedicine.39.324.

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Rattan, Suresh I. S. "Oxidative stress and aging." FEBS Letters 381, no. 3 (March 4, 1996): 262. http://dx.doi.org/10.1016/s0014-5793(96)90651-1.

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Junqueira, Virginia B. C., Silvia B. M. Barros, Sandra S. Chan, Luciano Rodrigues, Leandro Giavarotti, Ronaldo L. Abud, and Guilherme P. Deucher. "Aging and oxidative stress." Molecular Aspects of Medicine 25, no. 1-2 (February 2004): 5–16. http://dx.doi.org/10.1016/j.mam.2004.02.003.

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Abdollahi, Mohammad, Majid Y. Moridani, Okezie I. Aruoma, and Sara Mostafalou. "Oxidative Stress in Aging." Oxidative Medicine and Cellular Longevity 2014 (2014): 1–2. http://dx.doi.org/10.1155/2014/876834.

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Chen, Danica. "OXIDATIVE STRESS AND AGING." Free Radical Biology and Medicine 53 (November 2012): S3. http://dx.doi.org/10.1016/j.freeradbiomed.2012.10.006.

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Lesnefsky, Edward J., and Charles L. Hoppel. "Oxidative phosphorylation and aging." Ageing Research Reviews 5, no. 4 (November 2006): 402–33. http://dx.doi.org/10.1016/j.arr.2006.04.001.

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Dissertations / Theses on the topic "Oxidative Aging"

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AragÃo, Theresa Christine Filgueiras Russo. "Oxidative damages and ageing bean seeds Caupi." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=17178.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico
The present study was carried out to elucidate the relationship between seed ageing and oxidative damage in two cowpea (Vigna unguiculata (L.) Walp.) cultivars, namely PitiÃba and PÃrola.The seeds were articially aged at 45 ÂC and 99% relative humidity until 72 h and daily harvested. Seed germination, electrolyte leakage, lipid and protein oxidation were evaluated. Moreover, changes in superoxide dismutase (SOD), ascorbate peroxidase (APX) and catalase (CAT) activity as their isoform pattern and CAT and APX mRNA expression were also investigated. Only in PÃrola seeds germinability was decreased whereas electrolyte leakage was increased with artificial ageing, indicating membrane damage. Moreover, PÃrola seeds presented higher lipid and protein oxidative damage than the PitiÃba ones. Total SOD activity was not altered by the treatment in both cultivars. Zymogram analysis reveled five different isoforms, designated SOD1 to SOD5 according to the eletrophoretic migration. No significant difference in the SOD isoenzyme pattern up to 72 h were detected. Specific inhibition with peroxide and cyanide showed SOD1 and SOD2 as SOD-Mn and SOD3, SOD4 and SOD5 as SOD-Cu/Zn isoforms. It was verified a cross-talk between CAT and APX activities through artificial ageing. At 72 h of treatment, CAT mRNA expression and activity increased in PitiÃba seeds and decreased in the PÃrola ones. Conversely, APX mRNA expression and activity showed an opposite pattern in the studied cultivars. Imunoblot analysis demostrated that no significant changes in CAT content were verified in PÃrola and PitiÃba seeds during induced aging. Thus, the CAT turnover did not necessarily involve coordinated mRNA synthesis, protein synthesis and protein degradation. In conclusion, lipid and protein oxidative damage were narrowly involved in seed aging in cowpea. PitiÃba seeds were more resistant to age-induced oxidative damage than that of PÃrola. PitiÃba seed resistance against aging were related to induced CAT expression and its activity, suggesting that this enzime play a role in oxidative damage protection.
O presente estudo foi desenvolvido na intenÃÃo de elucidar a relaÃÃo entre o envelhecimento de sementes e danos oxidativos em duas cultivares contrastantes de caupi (Vigna unguiculata (L.) Walp.), denominadas PitiÃba e PÃrola. As sementes foram artificialmente envelhecidas a 45 ÂC e 99% de umidade relativa atà 72 h e coletadas diariamente. GerminaÃÃo de sementes, vazamento de eletrÃlitos, oxidaÃÃo de lipÃdios e proteÃnas foram avaliados. AlÃm disso, alteraÃÃes em atividade de enzimas como dismutase de superÃxido (SOD), peroxidase de ascorbato (APX) e catalase (CAT) assim como o padrÃo de suas isoformas e expressÃo de RNAm de CAT e APX tambÃm foram investigados. Somente em sementes de PÃrola decresceu a germinabilidade enquanto que aumentou significativamente o vazamento de eletrÃlitos com o envelhecimento artificial, indicando danos de membrana. AlÃm disso, sementes de PÃrola apresentaram maiores danos oxidativos em lipÃdios e proteÃnas do que sementes de PitiÃba. A atividade total da SOD nÃo foi alterada durante o tratamento de sementes em ambas cultivares. AnÃlise de zimograma revelou cinco diferentes isoformas, designadas SOD1 a SOD5 de acordo com a migraÃÃo eletroforÃtica. NÃo houve diferenÃa significativa no padrÃo isoenzimÃtico de SOD durante as 72 h de tratamento. InibiÃÃo especÃfica com perÃxido de hidrogÃnio e cianeto revelou as isoformas SOD1 e SOD2 como SOD-Mn e SOD3, SOD4 e SOD5 com SOD Cu/Zn. Foi verificado um âcross-talkâ entre as atividades de CAT e APX durante o envelhecimento artificial. As 72 h de tratamento, a expressÃo de RNAm de CAT e sua atividade aumentaram em PitiÃba e diminuÃram em sementes de PÃrola. A expressÃo e a atividade de APX demonstrou um padrÃo oposto nas cultivares estudadas. AnÃlise de imunoblot demonstrou que nÃo houve alteraÃÃes significativas no conteÃdo de CAT em ambas as cultivares durante a induÃÃo do envelhecimento. Desse modo, o turnover de CAT nÃo envolve necessariamente a sÃntese coordenada de RNAm, sÃntese de proteÃna e degradaÃÃo de proteÃna. Em conclusÃo, danos oxidativos em lipÃdios e proteÃnas estÃo estreitamente envolvidos no envelhecimento de sementes de caupi. Sementes de PitiÃba sÃo mais resistentes aos danos oxidativos induzidos por envelhecimento do que sementes de PÃrola. A resistÃncia de sementes de PitiÃba contra o envelhecimento parece estar relacionada à induÃÃo da expressÃo e atividade de CAT, sugerindo que esta enzima realiza uma funÃÃo protetora contra danos oxidativos.
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Garg, Richa [Verfasser], and Elmar [Akademischer Betreuer] Heinzle. "Oxidative stress induced alterations during aging : quantifying the metabolic changes associated with aging and oxidative stress / Richa Garg ; Betreuer: Elmar Heinzle." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1140043331/34.

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Jervis, Kathryn. "Oxidative stress and aging of the male reproductive tract." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84264.

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The global demographic shift towards population aging will result in a dramatic increase in the numbers of elderly in the population. In order to cope with these changing demographics, it is imperative that we better understand aging and age-related pathologies. The reproductive tract provides an excellent system in which to study aging in that it is affected by aging, without compromising the overall health of the individual. In the Brown Norway rat model, the male reproductive tract (testis and epididymis) shows numerous signs of aging when other systems remain relatively unaffected by age, thus making this system ideal for studies on underlying causes of aging. One of the many theories proposed to account for the aging process is oxidative stress. Moreover, some of the changes that take place in the aging epididymis are suggestive of oxidative stress. In order to understand the contribution of oxidative stress to aging of the epididymis, we undertook global gene expression studies of the tissue in the young animal and then assessed how this gene expression was affected by age. We manipulated oxidative stress by caloric restriction and antioxidant (vitamin E) supplementation and deficiency. In characterizing the longitudinal gene expression in the young epididymis, we identified many genes never before reported in this tissue. We found that age profoundly affects gene expression in the epididymis and that the expression of oxidative stress related transcripts decreased, most dramatically in the distal (corpus and cauda epididymidis) regions of the tissue. Caloric restriction attenuated or reversed many of the gene expression changes that took place with age. The effect of caloric restriction was greatest for transcripts associated with protein synthesis and mitochondrial function. Finally, we found that long term antioxidant (vitamin E) deficiency resulted in increased expression of oxidative stress transcripts and exacerbated the effect
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Tsirklin, Liana. "Role of NADPH Oxidase in Oxidative Stress and Aging." Thesis, The University of Arizona, 2012. http://hdl.handle.net/10150/245082.

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As people age, their preferential adipose tissue stores tend to shift from subcutaneous to visceral, which could lead to diabetes, since visceral adipose tissue is insulin resistant. One of the proposed mechanisms for this shift is due to elevated levels of oxidative stress in adipose tissue cells due to aging, as a result of increased levels of NADPH oxidase (NOX). The goal of these experiments is to determine the existence and significance of this potential correlation. Visceral, subcutaneous, and stromal vascular adipose tissue samples from 18 week and 20 month old mice were probed for p47phox levels, a crucial component of NOX, and the levels of oxidative stress were also determined through a dinitrophenolhydrazine reaction in the OxyBlot analysis. In order to achieve these goals, electrophoresis gels were run, the gels were transferred through standard Western blot procedures, then probed with primary and secondary antibodies, and finally scanned and analyzed to determine differences in signal. As of yet, there have not been any statistically significant differences in oxidative stress levels determined in young and old mice, but further experiments will be conducted in order to validate these findings.
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Pournoman, Sara. "Oxidative Aging of Binders with High Recycled Asphalt Materials." Thesis, University of Nevada, Reno, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10282654.

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The objectives of this research effort focused on the oxidative aging of binders with high recycled asphalt materials. A coordinated program of forced-draft oven aging experiments was conducted on eleven sorts of binder blends including three different types of base binders from TX, NH, and NV, two different types of recycled material (RAP/RAS), and two different types of recycling agents (RA). Implementing the Fourier-Transform Infrared Spectroscopy (FT-IR) and Dynamic Shear Rheometer (DSR) isothermal frequency sweep tests, the oxidation kinetics and rheological performance were determined for the evaluation materials. Results indicated that the oxidative aging rates were influenced by the aging temperature, duration, base binder type, as well as the utilized asphalt modifier, i.e. recycled materials and RAs. It was also noted that the RAs reduced the overall stiffness in the investigated stages of oxidation. However, differential aging rates and hardening susceptibilities were observed between the RA and RAP/RAS additions to each of the three bases, noting that these differences were not consistent with the type of RAS, i.e. MWAS or TOAS. Additionally, the base binder aging properties due to the addition of the recycled material was highly influenced by the RA dosages within each blend.

Furthermore, the binder blend oxidative aging predictions at binder specific geographical location indicated that using the recycled materials along with the RAs at the optimum dosage, according to the proposed methodology, was able to restore the binder blend properties to the virgin binder.

The influences of the recycled material and RAs on the PG 64-28P base binder were also investigated through the binder PG grading and mortar testing. Consistent directions for the influence of the evaluation materials were observed within both procedures, suggesting the capability of the mortar procedure in characterizing the effects of RAP and RA materials on virgin binder without the use of chemical extraction.

The Uniaxial Thermal Stress and Strain Test (UTSST) was also conducted on the PMFC and RPMLC specimens of the NV field project to investigate the influence of the high recycled material and RAs on the asphalt mixtures. Through consideration of the thermo-viscoelastic properties, marked differences in the binder oxidation were noted between the experimental factors. Typically, decreases in the viscous response of the mixtures as well as increases in both the stiffness and brittle behavior were observed with aging and also inclusion of the recycled material. Although the addition of the RAs to the recycled mixtures indicated some extent of properties restoration, crack initiation and fracture were observed to occur in significantly warmer temperatures compared to the virgin mixture.

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Li, Ying Bo. "Anti-oxidative and pro-oxidative effects of curcuminoids on cellular senescence in aging and cancer." Thesis, University of Macau, 2011. http://umaclib3.umac.mo/record=b2492795.

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Lemon, Jennifer Rollo C. David. "Oxidative stress and aging processes in transgenic growth hormone mice." *McMaster only, 2005.

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Aragão, Theresa Christine Filgueiras Russo. "Danos oxidativos e o envelhecimento de sementes de feijão Caupi." reponame:Repositório Institucional da UFC, 2007. http://www.repositorio.ufc.br/handle/riufc/18805.

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ARAGÃO, Theresa Christine Filgueiras Russo. Danos oxidativos e o envelhecimento de sementes de feijão Caupi. 2007. 143 f. Tese (Doutorado em bioquímica)- Universidade Federal do Ceará, Fortaleza-CE, 2007.
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The present study was carried out to elucidate the relationship between seed ageing and oxidative damage in two cowpea (Vigna unguiculata (L.) Walp.) cultivars, namely Pitiúba and Pérola.The seeds were articially aged at 45 ºC and 99% relative humidity until 72 h and daily harvested. Seed germination, electrolyte leakage, lipid and protein oxidation were evaluated. Moreover, changes in superoxide dismutase (SOD), ascorbate peroxidase (APX) and catalase (CAT) activity as their isoform pattern and CAT and APX mRNA expression were also investigated. Only in Pérola seeds germinability was decreased whereas electrolyte leakage was increased with artificial ageing, indicating membrane damage. Moreover, Pérola seeds presented higher lipid and protein oxidative damage than the Pitiúba ones. Total SOD activity was not altered by the treatment in both cultivars. Zymogram analysis reveled five different isoforms, designated SOD1 to SOD5 according to the eletrophoretic migration. No significant difference in the SOD isoenzyme pattern up to 72 h were detected. Specific inhibition with peroxide and cyanide showed SOD1 and SOD2 as SOD-Mn and SOD3, SOD4 and SOD5 as SOD-Cu/Zn isoforms. It was verified a cross-talk between CAT and APX activities through artificial ageing. At 72 h of treatment, CAT mRNA expression and activity increased in Pitiúba seeds and decreased in the Pérola ones. Conversely, APX mRNA expression and activity showed an opposite pattern in the studied cultivars. Imunoblot analysis demostrated that no significant changes in CAT content were verified in Pérola and Pitiúba seeds during induced aging. Thus, the CAT turnover did not necessarily involve coordinated mRNA synthesis, protein synthesis and protein degradation. In conclusion, lipid and protein oxidative damage were narrowly involved in seed aging in cowpea. Pitiúba seeds were more resistant to age-induced oxidative damage than that of Pérola. Pitiúba seed resistance against aging were related to induced CAT expression and its activity, suggesting that this enzime play a role in oxidative damage protection.
O presente estudo foi desenvolvido na intenção de elucidar a relação entre o envelhecimento de sementes e danos oxidativos em duas cultivares contrastantes de caupi (Vigna unguiculata (L.) Walp.), denominadas Pitiúba e Pérola. As sementes foram artificialmente envelhecidas a 45 ºC e 99% de umidade relativa até 72 h e coletadas diariamente. Germinação de sementes, vazamento de eletrólitos, oxidação de lipídios e proteínas foram avaliados. Além disso, alterações em atividade de enzimas como dismutase de superóxido (SOD), peroxidase de ascorbato (APX) e catalase (CAT) assim como o padrão de suas isoformas e expressão de RNAm de CAT e APX também foram investigados. Somente em sementes de Pérola decresceu a germinabilidade enquanto que aumentou significativamente o vazamento de eletrólitos com o envelhecimento artificial, indicando danos de membrana. Além disso, sementes de Pérola apresentaram maiores danos oxidativos em lipídios e proteínas do que sementes de Pitiúba. A atividade total da SOD não foi alterada durante o tratamento de sementes em ambas cultivares. Análise de zimograma revelou cinco diferentes isoformas, designadas SOD1 a SOD5 de acordo com a migração eletroforética. Não houve diferença significativa no padrão isoenzimático de SOD durante as 72 h de tratamento. Inibição específica com peróxido de hidrogênio e cianeto revelou as isoformas SOD1 e SOD2 como SOD-Mn e SOD3, SOD4 e SOD5 com SOD Cu/Zn. Foi verificado um “cross-talk” entre as atividades de CAT e APX durante o envelhecimento artificial. As 72 h de tratamento, a expressão de RNAm de CAT e sua atividade aumentaram em Pitiúba e diminuíram em sementes de Pérola. A expressão e a atividade de APX demonstrou um padrão oposto nas cultivares estudadas. Análise de imunoblot demonstrou que não houve alterações significativas no conteúdo de CAT em ambas as cultivares durante a indução do envelhecimento. Desse modo, o turnover de CAT não envolve necessariamente a síntese coordenada de RNAm, síntese de proteína e degradação de proteína. Em conclusão, danos oxidativos em lipídios e proteínas estão estreitamente envolvidos no envelhecimento de sementes de caupi. Sementes de Pitiúba são mais resistentes aos danos oxidativos induzidos por envelhecimento do que sementes de Pérola. A resistência de sementes de Pitiúba contra o envelhecimento parece estar relacionada à indução da expressão e atividade de CAT, sugerindo que esta enzima realiza uma função protetora contra danos oxidativos.
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Luciano, Mateo Fedra Nicaury. "The role of chemokine (c-c motif) ligand 2 in inflammation, oxidative stress, aging and metabolism." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/667564.

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El metabolisme i el sistema immunològic estan estretament relacionats i les seves interaccions juguen un paper important en l'homeòstasi sistèmica. L'activació, proliferació, diferenciació i polarització de les cèl·lules immunitàries representen un important estrès metabòlic, que pot comprometre el metabolisme cel·lular, l'homeòstasi i les necessitats energètiques. Aquestes condicions poden promoure l'estrès metabòlic crònic i les anomalies metabòliques en patologies no immunes. No obstant això, encara no queda clar com aquests canvis en el perfil immunològic afecten el metabolisme sistèmic. Cada vegada hi ha més proves de que les quimiocines exerceixen un paper crucial en tots aquests processos. Especialment, l'augment de la quimiocina C-C motif ligand 2 (CCL2) en malalties metabòliques suggereix la possibilitat que aquesta jugui un rol en la regulació del metabolisme. La pregunta clau és si l'augment de CCL2 és la causa o conseqüència del problema. Per aquesta raó, explorem l'efecte de la deficiència de CCL2 en el metabolisme de ratolins amb hiperlipèmia, esteatosis hepàtica i síndrome metabòlica. A més, es va investigar si aquest efecte podria estar condicionat per la dieta. Els resultats obtinguts es presenten en el primer estudi. Aquests resultats obren la porta a altres preguntes. Per exemple, la funció CCL2 va més enllà de la seva capacitat d'atraure cèl·lules immunitàries? Pot aquesta quimiocina afectar el metabolisme energètic? Per a respondre a aquestes preguntes, generem ratolins CCL2 cisgenic. Els resultats es presenten en l'estudi 2. En l'estudi 3 es va avaluar l'efecte de la sobre-expressió de CCL2 en un model de ratolí de la síndrome de progèria de Hutchinson-Gilford, un model d'envelliment accelerat. La cerca de dianes terapèutiques per al tractament de malalties metabòliques és un punt important en les recerques actuals. Els resultats d'aquesta tesi suggereixen que la CCL2 podria ser una diana terapèutica important en diferents malalties metabòliques.
El metabolismo y el sistema inmunológico están estrechamente relacionados y sus interacciones juegan un papel importante en la homeostasis sistémica. La activación, proliferación, diferenciación y polarización de las células inmunitarias representan un importante estrés metabólico, que puede comprometer el metabolismo celular, la homeostasis y las necesidades energéticas. Estas condiciones pueden promover el estrés metabólico crónico y las anomalías metabólicas en patologías no inmunes. Sin embargo, aún no está claro cómo estos cambios en el perfil inmunológico afectan al metabolismo sistémico. Cada vez hay más pruebas de que las quimiocinas desempeñan un papel crucial en todos estos procesos. Especialmente, el aumento de la quimiocina C-C motif ligand 2 (CCL2) en enfermedades metabólicas sugiere la posibilidad de que esta juegue un papel en la regulación del metabolismo. La pregunta clave es si el aumento de CCL2 es la causa o consecuencia del problema. Por esta razón, exploramos el efecto de la deficiencia de CCL2 en el metabolismo de ratones con hiperlipidemia, esteatosis hepática y síndrome metabólico. Además, se investigó si ese efecto podría estar condicionado por la dieta. Los resultados obtenidos se presentan en el primer estudio. Estos resultados abren la puerta a otras preguntas. Por ejemplo, ¿la función de CCL2 va más allá de su capacidad de atraer células inmunitarias? ¿Puede esta quimiocina afectar el metabolismo energético? Para responder a estas preguntas, generamos ratones CCL2 cisgénicos. Los resultados se presentan en el estudio 2. En el estudio 3 se evaluó el efecto de la sobreexpresión de CCL2 en un modelo de ratón del síndrome de progeria de Hutchinson-Gilford, un modelo de envejecimiento acelerado. La búsqueda de dianas terapéuticas para el tratamiento de enfermedades metabólicas es un punto importante en las investigaciones actuales. Los resultados de esta tesis sugieren que CCL2 podría ser una diana terapéutica importante en diferentes enfermedades metabólicas.
Metabolism and immune system are closely interconnected and their interactions play an important role in whole-body homeostasis. The activation, proliferation, differentiation and polarization of the immune cells represent significant metabolic stress, which can compromise the cellular metabolism, homeostasis and energetics requirements. These conditions can promote the chronic metabolic stress and metabolic abnormalities in non-immune pathologies. Nevertheless, how these changes in the immunological profile affect systemic metabolism are still not clear. Growing evidences support that chemokines play a crucial role in all these processes. Specially, the increase of chemokine C-C motif ligand 2 (CCL2) in metabolic diseases suggests the possibility of this chemokine to play a systemic role in the regulation of metabolism. The key question is if increase of CCL2 is the cause or consequence of the problem. For this reason, we explored the effect of CCL2 ablation in the metabolism of mice with a background of hyperlipidemia, hepatic steatosis and metabolic syndrome. In addition, we investigated whether that effect might be conditioned by diet. Obtained results are presented in the first study. These results open a brief to other questions. For example, does CCL2 function go further to its chemoattracting capacity? Can this chemokine affect the systemic energy metabolism? To answer these questions, we generated targeted CCL2 cisgenic mice, which overexpressed CCL2 in all tissues and results are presented in study 2. In study 3 we evaluated the effect of CCL2 overexpression in a mice model of Hutchinson-Gilford progeria syndrome, a model of accelerated aging. The finding of therapeutic targets for the treatment of metabolic diseases is an important point in current investigations in our research group. The conclusions of this thesis suggest that CCL2 could be an important therapeutic target in different metabolic diseases.
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Shao, Changxing. "OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION IN TRAUMATIC BRAIN INJURY IN AGING." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_diss/533.

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Traumatic brain injury (TBI) is a prominent disease in developed countries, and age is an important factor in functional outcome. Although aged patients typically show diminished recovery compared to young patients, and have higher mortality and morbidity following TBI, the mechanism is not well understood. To date, there is no effective therapeutic for TBI. Previous studies indicate a secondary injury in TBI begins immediately after impact, and is likely the major contribution to delayed neuron dysfunction and loss. Studies also suggest mitochondrial dysfunction and increased free radical species (ROS) production following TBI may play a key role in the process. To evaluate oxidative damage following TBI, especially in aging, young (3 months), middle aged (12 months) and aged (22 months) Fisher-344 rats were subjected to a unilateral controlled cortical impact (CCI) injury, and tissue sparing, 4-hydroxynonenal (HNE) and acrolein levels, and antioxidant enzyme activities, and DNA oxidative damage were measured. In order to evaluate changes in mitochondria following TBI, mitochondrial protein levels were investigated using young adult animals. To evaluate a potential therapeutic for TBI, the effect of creatine on oxidative damage was evaluated. These studies show an age dependent increase of oxidative damage following TBI, demonstrated by increased levels of 4-HNE, acrolein and 8-hydroxyguanine. Middle aged and aged animals showed increased tissue loss compared to young animals 7 days post injury. Mitochondrial proteins involved in the respiratory chain, carrier proteins and channel proteins were significantly decreased 24 h post injury in ipsilateral cortex, but increased in both ipsilateral and contralateral hippocampus. To study potentially protective compounds in TBI, animals were fed with creatine two weeks before TBI and showed less oxidative damage and increased antioxidant capacity, which suggests creatine may be a potential drug for clinical treatment of TBI. The work described in this dissertation is the first to show increased oxidative damage and diminished antioxidant capacity in TBI in aging. The study of mitochondriafollowing TBI using quantitative proteomics is also the first time to show multiple mitochondrial proteins change following TBI. These data are also the first to show creatine can increase antioxidant defenses. These studies contribute to our understanding the mechanisms of secondary injury in TBI in aging.
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Books on the topic "Oxidative Aging"

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Cutler, R. G., L. Packer, J. Bertram, and A. Mori, eds. Oxidative Stress and Aging. Basel: Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7337-6.

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Miwa, Satomi, Kenneth B. Beckman, and Florian L. Muller, eds. Oxidative Stress in Aging. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-420-9.

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Bondy, Stephen C., and Arezoo Campbell, eds. Inflammation, Aging, and Oxidative Stress. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-33486-8.

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Vitamin D: Oxidative stress, immunity, and aging. Boca Raton: Taylor & Francis, 2013.

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Poljsak, Borut. Decreasing oxidative stress and retarding the aging process. Hauppauge, N.Y: Nova Science Publishers, 2010.

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Veasey, Sigrid C. Oxidative Neural Injury. Totowa, NJ: Humana Press, 2009.

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Ren lei shou ming xue. Beijing Shi: Zhongguo yi yao ke ji chu ban she, 2007.

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NATO, Advanced Research Workshop on Frontiers in Neurodegenerative Disorders and Aging: Fundmental Aspects Clinical Perspectives and New Insights (2003 Antalya Turkey). Frontiers in neurodegenerative disorders and aging: Fundamental aspects, clinical perspectives and new insights. Amsterdam: IOS Press, 2004.

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Poljsak, Borut. Skin aging, free radicals, and antioxidants. New York: Nova Science Publishers, 2012.

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Knight, Joseph A. Free radicals, antioxidants, aging and disease. Washington, D.C: AACC Press, 1999.

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Book chapters on the topic "Oxidative Aging"

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Gooch, Jan W. "Oxidative Aging, Elastomers." In Encyclopedic Dictionary of Polymers, 510. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_8315.

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Tian, Zhijie, and Xiaozhen Dai. "Oxidative Stress-Mediated Stem Cell Aging." In Oxidative Stress, 55–76. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0522-2_3.

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Esfahani, Behjat Al-Sadat Moayedi, Milad Mirmoghtadaei, and Sima Balouchi Anaraki. "Oxidative Stress and Aging." In Immunology of Aging, 323–38. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-39495-9_24.

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Dröge, Wulf. "Oxidative Stress and Aging." In Advances in Experimental Medicine and Biology, 191–200. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-8997-0_14.

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Slater, A. F. G., and S. Orrenius. "Oxidative stress and apoptosis." In Oxidative Stress and Aging, 21–26. Basel: Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7337-6_3.

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Didion, Sean P., Sophocles Chrissobolis, and Frank M. Faraci. "Oxidative Stress in Hypertension." In Oxidative Stress in Aging, 229–51. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-420-9_13.

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Ishii, Naoaki, Takamasa Ishii, and Philip S. Hartman. "Oxidative Stress and C. elegans Models." In Aging Mechanisms, 111–22. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55763-0_7.

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Matsuo, M., H. Yuan, and S. Honda. "Cellular aging and oxidative stress." In Oxidative Stress and Aging, 35–43. Basel: Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7337-6_5.

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Packer, L. "Oxidative stress, antioxidants, aging and disease." In Oxidative Stress and Aging, 1–14. Basel: Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7337-6_1.

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Randerath, K., J. Chang, and E. Randerath. "Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stress." In Oxidative Stress and Aging, 77–87. Basel: Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7337-6_10.

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Conference papers on the topic "Oxidative Aging"

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Tarefder, Rafiqul A., and Iffat R. Arisa. "Molecular Dynamic Simulation of Oxidative Aging in Asphaltene." In Pavements and Materials: Characterization and Modeling Symposium at EMI Conference 2010. Reston, VA: American Society of Civil Engineers, 2010. http://dx.doi.org/10.1061/41129(385)2.

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Mohammadi, Hamid, and Roozbeh Dargazany. "Micro-Mechanical Model for Thermo-Oxidative Aging of Elastomers." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-88109.

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In this study, a micro-mechanical model for constitutive behavior of elastomers subjected to thermo-oxidative aging is proposed. The model is based on the network decomposition concept and lies within the framework of continuum mechanics. It is assumed that the aging process leads to the formation of a new network with tighter chains. Accordingly, the strain energy of the system is constituted of two independent sources, the energy of the original soft network and the one of the reformed network. These strain energies were computed by integration of entropic energy of polymer chains in each direction of a micro-sphere. The model demonstrates good agreement with different experimental data on relaxation and intermittent tests.
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Liu, Chengchu, Dexiang Peng, Jingya Yang, Yingsen Li, and Jiale Li. "Anti-oxidative and anti-aging activities of collagen hydrolysate." In 2010 3rd International Conference on Biomedical Engineering and Informatics (BMEI). IEEE, 2010. http://dx.doi.org/10.1109/bmei.2010.5639440.

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ZHAO, YONGXIAN, CHEN MA, MENG TANG, YANQIU YANG, YANHONG HUANG, YANSONG BAO, and JIANGUO GAO. "Study on the Structure of Poly(ethylene terephthalate) with Thermal-oxidative Aging." In The 21st IAPRI World Conference on Packaging. Lancaster, PA: DEStech Publications, Inc., 2018. http://dx.doi.org/10.12783/iapri2018/24462.

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Torres-Gonzalez, Edilson, Dean P. Jones, Dan Sorescu, Mauricio Rojas, Arlene Stecenko, and Ana L. Mora. "Oxidative Stress And Susceptibility To Virus-Induced Lung Fibrosis In Aging Mice." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1997.

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McGovern, Megan, Behzad Behnia, Brian Hill, William G. Buttlar, and Henrique Reis. "Characterization of oxidative aging in asphalt concrete pavements using its complex moduli." In SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, edited by Tribikram Kundu. SPIE, 2014. http://dx.doi.org/10.1117/12.2044781.

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Korayem, Abd-Elrahman, Hamid Mohammadi, and Roozbeh Dargazany. "Experimental Investigation on the Performance Loss of Cross-Linked Polymers During Photo-Oxidative Aging." In ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-24318.

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Abstract Polymeric substances have seen an unprecedented integration in countless applications and fields of life, subjecting them to a broad range of environmental conditions, which can cause a form of damage to the structural and mechanical properties of these components known as aging. In this study we investigate the effects of the degradation of polymeric materials due to the extended exposure to sunlight, which can be simulated through controlled photo-oxidative aging using ultraviolet (UV) radiation as the main catalyst of this phenomenon. The effects on mechanical behavior and chemical properties of four polymeric materials with different mechanical characteristics was accordingly monitored throughout the study. The materials range in hardness with the polyurethane adhesive being the hardest and acting plastically, followed by an acrylic which exhibits greater hardening with time, a polyurethane sealant, which behaves in an elastomeric manner, and a silicon sealant, which is the softest of the set. Samples were prepared and subjected to UV radiation at three different temperatures namely 45, 60 and 80°C, for different aging periods ranging from 1 day for higher temperatures to 150 days for lower ones. The samples were then subjected to the Fourier transform Infrared spectroscopy (FTIR) test to monitor the change in the chemical composition of the materials along the aging durations and conditions. The materials were then subjected to mechanical testing along two modes of mechanical loading, which are a simple tension until failure and a double-cyclic test with progressively increasing strain limits after every two successful cycles until the sample reaches failure. The samples are loaded at constant strain rates throughout both tests. These tests revealed the change of behavior of our materials along the aging periods and conditions. The changes in mechanical behavior vary across each individual material depending on the aging temperature and period, with the changes ranging from hardening to softening, embrittlement or an increase in the maximum strain the material can endure before failure. A general trend would be that most materials become harder after photo-oxidation, however due to the range of temperatures in the aging conditions, thermo-oxidation, which causes softening in some of the polymers, has an increasingly notable effect at higher temperatures. A visible correlation can be noted between the change in mechanical behavior and a change in absorbance of Infrared Radiation (IR) in the FTIR spectrum, as the greater the crosslinking throughout the polymer matrix, the lower the absorbance of IR radiation due to the increased stiffness of the overall macro-molecular structure.
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Dasharathi, Kannan, and John A. Shaw. "The Influence of Thermo-Oxidative Degradation on the Behavior of Epoxy Shape Memory Polymers." In ASME 2014 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/smasis2014-7478.

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Results are reported from an ongoing experimental investigation of the effects of thermo-oxidative aging on the mechanical behavior of an epoxy shape memory polymer (SMP). Chemo-rheological degradation due to macromolecular scission and cross-linking is one of the main factors contributing to the chemical aging of thermo-responsive SMPs. This aging may manifest as residual strain or irreversible material property changes, which can affect the performance and limit the useful life of a SMP. A relatively new epoxy SMP based on the diglycidyl ether of bisphenol A is synthesized, and specimens are tested under uni-axial tension using a dynamic mechanical analyzer. Fundamental viscoelastic behavior and thermal expansion coefficients are first characterized, showing a glass transition near 60 °C. Shape memory cycle experiments are performed at shape fixing temperatures of 80, 125, 150 and 175 °C, and the effect of fixing time at each temperature is examined upon subsequent strain recovery at 80 °C. Performance parameters such as recovery ratio, speed of recovery and residual strain are quantified as a function of shape fixing time and temperature. No effect of chemical aging was seen at a fixing temperature of 80 °C, although the recovery ratio decreases initially with increasing fixing time and stabilizes near 92 %. Only minor effects of chemical aging are seen in the mechanical responses for fixing temperatures of 125 and 150 °C, but specimens exhibit progressively more noticeable color changes that indicate oxidation. Significant effects are observed at the highest fixing temperature of 175 °C, where chemical aging at longer fixing times results in a reduction in recovery rate across the rubber-glass transition temperature, progressively larger residual strains, lack of complete strain recovery at 80 °C, and higher temperatures to achieve 90 % strain recovery.
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Faisal, Hasan, Mohiuddin Ahmad, and Rafiqul Tarefder. "Effects of Pores and Oxidative Aging on the Nanomechanical Behavior of Asphalt Concrete." In International Conference on Transportation and Development 2018. Reston, VA: American Society of Civil Engineers, 2018. http://dx.doi.org/10.1061/9780784481554.028.

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Boucher, V., P. Rain, G. Teissedre, and P. Schlupp. "Evolution of structural properties of glass-mica-epoxy insulations along accelerated thermo-oxidative aging." In 2008 Annual Report Conference on Electrical Insulation and Dielectric Phenomena. IEEE, 2008. http://dx.doi.org/10.1109/ceidp.2008.4772842.

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Reports on the topic "Oxidative Aging"

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Tobin, J. An internal report: Electron Spectroscopy of the Oxidation and Aging of U and Pu. Office of Scientific and Technical Information (OSTI), April 2015. http://dx.doi.org/10.2172/1184100.

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Peebles, D. E., J. A. Ohlhausen, M. T. Dugger, K. S. Varga, and R. M. Bryan. Aging model for solid lubricants used in weapon stronglinks: Oxidation chemistry and hardware review. Office of Scientific and Technical Information (OSTI), September 1997. http://dx.doi.org/10.2172/650268.

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Azman, Khairunnuur Fairuz. Effects Of Goat Milk On Memory Performance, Oxidative Status And Neurotrophic Factors In D-Galactose-Induced Ageing Rat Model. Biomedpress, 2019. http://dx.doi.org/10.15419/arr.2019.3.

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