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Dissertations / Theses on the topic 'Oxidative stress and'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Gregory, Mary Sarah-Jane, and n/a. "Thioredoxin and Oxidative Stress." Griffith University. School of Health Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040301.082639.

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The experiments described in this thesis involve the expression and characterisation of recombinant truncated thioredoxin (tTrx) and the potential involvement that thioredoxin (Trx) has in the cellular responses to oxidative stress. Truncated Trx (80 amino acids) was expressed from a plasmid containing the ORF for tTrx that had been introduced into E.coli BL-21(DE3) cells. The protein was initially extracted using a combination of high concentrations of urea, high pH levels, and multiple sonification steps to remove the tTrx from inclusion bodies formed during expression. This procedure pro

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2

Gregory, Mary Sarah-Jane. "Thioredoxin and Oxidative Stress." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/367183.

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The experiments described in this thesis involve the expression and characterisation of recombinant truncated thioredoxin (tTrx) and the potential involvement that thioredoxin (Trx) has in the cellular responses to oxidative stress. Truncated Trx (80 amino acids) was expressed from a plasmid containing the ORF for tTrx that had been introduced into E.coli BL-21(DE3) cells. The protein was initially extracted using a combination of high concentrations of urea, high pH levels, and multiple sonification steps to remove the tTrx from inclusion bodies formed during expression. This procedure pro

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3

Nälsén, Cecilia. "Measurement and evaluation of antioxidant status and relation to oxidative stress in humans /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6742.

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4

Byon, Chang Hyun. "Oxidative stress-stimulated vascular calcification." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2010r/byon.pdf.

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5

Vanderlelie, Jessica, and n/a. "Placental Oxidative Stress in Preeclampsia." Griffith University. School of Medical Science, 2006. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20060918.161726.

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Affecting 6-8% of all pregnancies, preeclampsia is the leading cause of maternal morbidity in the western world and is charactensed by hypertension, proteinuria, edema and platelet aggregation. Despite its prevalence and severity, no comprehensive theory or single factor has been suggested to explain the pathophysiology of this multi system disorder of pregnancy, with the only therapies being bed rest, pharmacological symptom management and if necessary early delivery. Oxidative stress plays an important role in the pathophysiology of preeclampsia, resulting from defective trophoblast invasion

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6

Afzal, Maryam. "Breast cancer and oxidative stress." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/55856/.

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Endocrine and anti-EGFR strategies are used to treat breast cancer. Unfortunately, resistance can be acquired. Deciphering resistance mechanisms remains essential to design treatments for this adverse state. Oxidative stress is the cellular imbalance of pro-oxidants (promoting cell death) and antioxidants (facilitating cell survival and chemotherapy/radiotherapy resistance). However, it remains unexplored whether endocrine or anti-EGFR resistance also associates with altered redox balance. In this project, redox balance was examined using in vitro human resistant breast cancer models TAMR, FAS

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7

Wood, Christopher. "Oxidative stress and seed survival." Thesis, Abertay University, 1998. https://rke.abertay.ac.uk/en/studentTheses/79d28b74-9210-4ebd-a3b8-66a610bd8c87.

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Free radical and aldehydic breakdown product content were determined, by EPR and UV / visible spectroscopy, primarily in intermediate (desiccation tolerant) seeds of <i>Carica papaya</i> L. (Papaya) and recalcitrant (desiccation intolerant) seeds of <i>Aesculus hippocastanum</i> L. (Horse chestnut), but also in other species covering a range of desiccation tolerances, with a view to determining the role of oxidative stress as a diagnostic marker for desiccation tolerance. Axes of non-senescent highly viable recalcitrant seeds of horse chestnut were metabolically active, contained products of l

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8

Bennett, Stuart James. "Oxidative stress biomarkers in dementia." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1449/.

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Alzheimer’s disease (AD) is a devastating neurodegenerative disorder which is thought to affect 26.6 million individuals worldwide. There is growing concern over a worldwide dementia epidemic that is predicted to develop over the coming decades. The evidence thus far suggests that increased levels of oxidative stress and vascular risk factors are two major contributors, amongst others, to AD development. The thesis aimed to investigate markers of oxidative stress in AD plasma. Moreover, the oxidative status of specific proteins was investigated using both hypothesis driven and proteomic approa

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9

Vanderlelie, Jessica. "Placental Oxidative Stress in Preeclampsia." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/365679.

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Affecting 6-8% of all pregnancies, preeclampsia is the leading cause of maternal morbidity in the western world and is charactensed by hypertension, proteinuria, edema and platelet aggregation. Despite its prevalence and severity, no comprehensive theory or single factor has been suggested to explain the pathophysiology of this multi system disorder of pregnancy, with the only therapies being bed rest, pharmacological symptom management and if necessary early delivery. Oxidative stress plays an important role in the pathophysiology of preeclampsia, resulting from defective trophoblast invasion

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10

Bolotta, Alessandra <1982&gt. "Oxidative Stress and Friedreich’s Ataxia." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6282/1/Bolotta_Alessandra_tesi.pdf.

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Friedreich’s Ataxia (FRDA) is a neurodegenerative disorder caused by a deficiency of the protein frataxin and characterized by oxidative stress. The first aim of my research project was to analyze the effects of tocotrienol in FRDA patients. Patients received for 2 months a low dose of tocotrienol. A number of biochemical parameters related to oxidative stress were studied. We consistently showed that taking for 2 months a low dose of tocotrienol led to the decrease of oxidative stress indexes in FRDA patients. Also, this study provides a suitable model to investigate the efficacy of natural c

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11

Bolotta, Alessandra <1982&gt. "Oxidative Stress and Friedreich’s Ataxia." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6282/.

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Friedreich’s Ataxia (FRDA) is a neurodegenerative disorder caused by a deficiency of the protein frataxin and characterized by oxidative stress. The first aim of my research project was to analyze the effects of tocotrienol in FRDA patients. Patients received for 2 months a low dose of tocotrienol. A number of biochemical parameters related to oxidative stress were studied. We consistently showed that taking for 2 months a low dose of tocotrienol led to the decrease of oxidative stress indexes in FRDA patients. Also, this study provides a suitable model to investigate the efficacy of natural c

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12

Collins, Tracey Helen. "Investigation into the Effects of Oxidative Stress on Reproductive Development." The University of Waikato, 2007. http://hdl.handle.net/10289/2364.

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Nuclear transfer (NT), or cloning, which is the transfer of a donor nucleus to a recipient enucleated oocyte, has been successfully achieved to produce viable offspring in many species. The process is very inefficient, as reprogramming of the donor nucleus is required, and losses are high throughout development. Placentation abnormalities are a common feature amongst cloned animals. Incomplete nuclear reprogramming and erroneous epigenetic imprinting may contribute to aberrant protein transcription and DNA mutations, affecting mitochondrial metabolism and inducing cellular stress. In vitro

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13

Rajaraman, Gnana Oli [Verfasser], and Helga [Akademischer Betreuer] Stopper. "Oxidative stress : role in genomic damage and disease = Oxidativer Stress / Gnana Oli Rajaraman. Betreuer: Helga Stopper." Würzburg : Universitätsbibliothek der Universität Würzburg, 2012. http://d-nb.info/1024851885/34.

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14

Silva, Andreza Amaral da [UNESP]. "Estudo clínico, hemagasométrico e do estresse oxidativo em ovinos clinicamente sadios portadores de pneumonia." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/101285.

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Made available in DSpace on 2014-06-11T19:31:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-02-09Bitstream added on 2014-06-13T20:41:36Z : No. of bitstreams: 1 silva_aa_dr_botfmvz.pdf: 1478521 bytes, checksum: 3590a41144246c2ed3a4619905b51919 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Nas espécies domésticas as pneumonias cursam com intensa resposta inflamatória e acúmulo de células fagocíticas nos pulmões, levando a danos expressivos das estruturas do trato respiratório e à função pulmonar devido ao estresse oxidativo decorrente da liberação de gran

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Silva, Andreza Amaral da. "Estudo clínico, hemagasométrico e do estresse oxidativo em ovinos clinicamente sadios portadores de pneumonia /." Botucatu, 2012. http://hdl.handle.net/11449/101285.

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Orientador: Roberto Calderon Gonçalves<br>Banca: Simone Biagio Chiacchio<br>Banca: Raimundo de Souza Lopes<br>Banca: Fernando José Benesi<br>Banca: Débora Cristina Damasceno<br>Resumo: Nas espécies domésticas as pneumonias cursam com intensa resposta inflamatória e acúmulo de células fagocíticas nos pulmões, levando a danos expressivos das estruturas do trato respiratório e à função pulmonar devido ao estresse oxidativo decorrente da liberação de grandes quantidades de Espécies Reativas do Oxigênio (ERO) durante a explosão respiratória. O objetivo deste estudo foi analisar o status oxidativo,

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16

Ferreira, Paula Souza. "Atividade anti-inflamatória e antioxidante de flavonoides cítricos em camundongos submetidos a dieta indutora do estado pró-inflamatório /." Araraquara, 2014. http://hdl.handle.net/11449/113840.

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Orientador: Thais Borges Cesar<br>Banca: Amanda Martins Baviera<br>Banca: Luis Carlos Spolidorio<br>Resumo: O estresse oxidativo e a inflamação na obesidade estão associados ao desenvolvimento de doenças crônicas, tais como o diabetes mellitus e as doenças cardiovasculares. A ingestão de dietas com alto teor de gorduras saturadas e açúcar, mas deficientes em compostos antioxidantes, contribui para o acúmulo de tecido adiposo e podem levar ao aumento de marcadores inflamatórios no sangue e tecidos. Os flavonoides cítricos possuem propriedades biológicas capazes de atenuar o estresse oxidativo e

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17

Ferreira, Paula Souza [UNESP]. "Atividade anti-inflamatória e antioxidante de flavonoides cítricos em camundongos submetidos a dieta indutora do estado pró-inflamatório." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/113840.

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Made available in DSpace on 2015-01-26T13:21:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-06-30Bitstream added on 2015-01-26T13:30:47Z : No. of bitstreams: 1 000797265_20160630.pdf: 140781 bytes, checksum: 4b566923c018030910c299869b78c0d1 (MD5) Bitstreams deleted on 2016-07-01T13:02:18Z: 000797265_20160630.pdf,. Added 1 bitstream(s) on 2016-07-01T13:03:16Z : No. of bitstreams: 1 000797265.pdf: 823819 bytes, checksum: 82bdb4c30be8ca9c7bb831e2a43e8816 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O estresse oxidativo e a inflamação na obesidad

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18

Kotecki, Claire. "Oxidative stress resistance in drosophila melanogaster." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527450.

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19

Anderson, Richard Anthony. "Lipids, oxidative stress and endothelial function." Thesis, King's College London (University of London), 2004. https://kclpure.kcl.ac.uk/portal/en/theses/lipids-oxidative-stress-and-endothelial-function(ca261d48-d716-4156-9a38-dbb72775b36a).html.

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20

Schock, Bettina C. "Oxidative stress in paediatric lung disease." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300998.

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21

Sacre, Sandra Michelle. "Endothelial cell annexins and oxidative stress." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394510.

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22

Yusof, Ashril bin. "Exercise-induced oxidative stress in erythrocytes." Thesis, University of Essex, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434390.

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23

Jan, Mohamed Hamid Jan. "Iron absorption : control and oxidative stress." Thesis, King's College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444192.

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24

Han, Bing. "Mechanistic Consequences of Cardiac Oxidative Stress." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1203478009.

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25

DHALIWAL, PARVIN. "PARKINSON'S GDNF THERAPY AND OXIDATIVE STRESS." Thesis, The University of Arizona, 2008. http://hdl.handle.net/10150/190438.

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26

Andrade, Lara Filipe Rocha. "Hereditary hemochromatosis: cellular response to oxidative stress." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12495.

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Mestrado em Bioquímica - Bioquímica Clínica<br>Iron is a key element for basic cellular functions. If iron homeostasis is not maintained it may lead to iron overload. Patients with Hereditary Hemochromatosis (HH) and with the C282Y HFE mutation have a progressive severe iron overload that, if it is not treated, may lead to tissue damage, that mostly culminate in hepatic cirrhosis and carcinoma. Having in mind that tissue damage in HH may be related with oxidative stress (OS) caused by iron toxicity, it is important to understand in what way the OS defense is acting in cells from HH patients wi

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27

Chang, Hui. "Oxidative stress in the retina an experimental study in the rat /." Lund : Dept. of Ophthalmology, University Hospital, Lund University, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39725792.html.

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28

Prado, Renato Paschoal [UNESP]. "Influência dos caretonóides, retinol e α-Tocoferol e dos polimorfismos dos genes CYP1A1, GSTP1, MTHFR (A1298C E C6777) E XRCC1 (194Trp E 399 Gln) sobre os níveis de danos oxidativos do DNA, de uracilas incorporadas ao DNA e da capacidade de reparo do DNA". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/104583.

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Made available in DSpace on 2014-06-11T19:33:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-03-01Bitstream added on 2014-06-13T19:26:38Z : No. of bitstreams: 1 prado_rp_dr_botfm.pdf: 1768816 bytes, checksum: 9cf30006e86899d47a461a8d33e92140 (MD5)<br>É crescente o número de estudos que demonstram a importância de micronutrientes e compostos bioativos presentes nos alimentos na prevenção de diversas doenças degenerativas crônicas. Entretanto vários estudos moleculares epidemiológicos têm demonstrado que além de fatores ambientais, como a dieta, essas doenças degenerativas podem ser

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Prado, Renato Paschoal. "Influência dos caretonóides, retinol e α-Tocoferol e dos polimorfismos dos genes CYP1A1, GSTP1, MTHFR (A1298C E C6777) E XRCC1 (194Trp E 399 Gln) sobre os níveis de danos oxidativos do DNA, de uracilas incorporadas ao DNA e da capacidade de reparo do DNA /". Botucatu, 2013. http://hdl.handle.net/11449/104583.

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Orientador: Marcelo Sady Plácido Ladeira<br>Banca: Luis Carlos Giarola<br>Banca: Alaor Aparecido Almeida<br>Banca: Aniele Radzikoski Agner<br>Banca: Rodrigo Otávio Alves de Lima<br>Resumo: É crescente o número de estudos que demonstram a importância de micronutrientes e compostos bioativos presentes nos alimentos na prevenção de diversas doenças degenerativas crônicas. Entretanto vários estudos moleculares epidemiológicos têm demonstrado que além de fatores ambientais, como a dieta, essas doenças degenerativas podem ser modulada por genes envolvidos no biometabolismo de xenobióticos, metabolis

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Plant, Stuart D. "The response of human umbilical vein endothelial cells and blood platelets to modified NiTi surfaces." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275630.

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31

Murray, Ashley Rebecca. "Oxidative stress in skin induced by chemical and physical agents." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4558.

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Thesis (Ph. D.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains xii, 203 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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Cruz, Daniel Filipe Soares Pereira da. "Lifestyle impact on human sperm oxidative balance." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13262.

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Mestrado em Biomedicina Molecular<br>Infertility is a clinical condition that affects about 15% of reproductive-aged couples worldwide. Half of these cases are due to male factors. A large percentage of male infertility cases are idiopathic, however, in the last years the influence of oxidative stress in decreased semen quality has been discussed. The lifestyle, including consumption of alcohol, tobacco, drugs and the alteration in circadian cycle, has been proposed as responsible for the increase of reactive oxygen species (ROS). This increase leads to an alteration of the balance between oxi

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Hammerman, Malin. "Oxidative Stress and Protein Acetylation in Adipocytes." Thesis, Linköpings universitet, Proteinkemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-75785.

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Obesity is an increasing health problem which is causally associated with insulin resistance and type 2 diabetes. Oxidative stress, i.e. overproduction of reactive oxygen species, is associated with insulin resistance and obesity and may be a major risk factor in the onset and progression of diabetes. Bernlohr Lab at University of Minnesota have study oxidative stress in adipocytes by silencing the enzyme glutathione S-transferase A-4 (GSTA4), an enzyme detoxifying 4-hydroxynonenal formed during oxidative stress. Their results indicate that lysine acetylation, an important post-translational m

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Sova, H. (Henri). "Oxidative stress in breast and gynaecological carcinogenesis." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526204062.

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Abstract Cancer is the leading cause of death worldwide. Despite the significant research effort, underlying mechanisms of carcinogenic processes are still poorly understood. In recent decades, a group of extremely reactive oxygen metabolites, reactive oxygen species (ROS), have been linked closely to carcinogenesis. Levels of ROS are constantly controlled by antioxidants to ensure stable redox balance in our cells. An aberrant cellular redox balance is thought to be connected to carcinogenesis by inflicting damage to cellular macromolecules and disturbing normal cellular signalling. In this w

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Flint, Annika. "The Oxidative Stress Defenses of Campylobacter jejuni." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32073.

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Campylobacter jejuni infection is one of the leading causes of gastroenteritis in humans worldwide. During colonization of the gastrointestinal tract, C. jejuni will be unavoidably exposed to reactive oxygen species (ROS) produced by the host immune system and other intestinal microbiota. Identification of defenses against ROS is therefore important for understanding how Campylobacter survives this environmental stress during infection. Construction of isogenic deletion mutants into genes encoding potential oxidative stress defense systems followed by phenotypic screening revealed genes import

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Li, Wei Beck Melinda A. "Nutritionally-induced oxidative stress and viral infection." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,523.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Nutrition." Discipline: Nutrition; Department/School: Public Health.

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Renganathan, Kutralanathan. "Oxidative stress and age related macular degeneration." online version, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1193002743.

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Garlick, Andrew P. "Carbohydrate metabolism during oxidative stress in plants." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270014.

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Watt, Jonathan. "Targeting oxidative stress after percutaneous coronary intervention." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2877/.

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Percutaneous coronary intervention (PCI) improves the blood supply to the heart by unblocking narrowed coronary arteries. Implantation of a coronary stent is usually required to scaffold the artery and improve long-term vessel patency. Drug-eluting stents (DES) have been developed to decrease the incidence of stent renarrowing, known as in-stent restenosis (ISR), the main limitation of bare metal stents (BMS). DES release potent drugs into the artery wall to inhibit cell division and attenuate ISR. However, this strategy can also impair vascular healing and increase the risk of stent thrombosi

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Thomson, Katrina. "Investigating and detecting biomarkers for oxidative stress." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2408/.

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It is widely reported that during periods of inflammation the heme enzyme, myeloperoxidase is generated by macrophages producing reactive oxidative species. Oxidative stress is the imbalance of these oxidative species which will lead to the post translational modification of proteins. Some biomarkers are proteins or post translational modifications that can be used to indicate disease and are becoming increasingly important particularly for the study of progressive diseases. Analysis of biomarkers in bodily fluids will not only be faster and less invasive than a biopsy but will also diagnose d

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Costa, N. J. "Mitochondrial protein thiol modifications during oxidative stress." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598052.

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The focus of this thesis is to investigate the interactions of mitochondrial protein thiols with ROS and examine the oxidation of these thiols in response to oxidative stress. Among these protein thiol modifications, an area of great interest is the interactions of mitochondrial protein thiols with glutathione, therefore possible connections between the modifications and cell death were investigated. I explored the possibility that staurosporine (STS) induces apoptosis via the mitochondrial pathway, causing early changes in the mitochondrial membrane potential (Δψ), by changing the thiol redox

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Wallace, Shona M. "The role of metallothionein in oxidative stress." Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318980.

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A cell culture model was developed to examine the role of metallothionein in oxidative stress. Chinese hamster ovary cells, which contain little endogenous metallothionein, were transfected with a metallothionein-expressing gene. Metallothionein content of the resultant cell lines ranged from a physiological level to a very high level. The major antioxidant enzyme activities did not vary between the cell lines. Glutathione content, and the proportion of glutathione that was oxidised, was higher than that of the wild type in one of the cell lines, indicating that this cell line had a different

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Gavriilidis, Christos. "Mitochondrial dysfunction and oxidative stress in osteoarthritis." Thesis, University of Newcastle upon Tyne, 2012. http://hdl.handle.net/10443/1599.

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Mitochondria are considered the powerhouse of the cell being the major site of ATP production but in addition to this function they also regulate ROS production and inhibition, calcium handling and apoptosis. Previous studies have reported a downregulation in the levels of superoxide dismutase 2 (SOD2), an inhibitor of mitochondrial superoxide (O2--), in osteoarthritic (OA) hip cartilage compared to that from healthy joints (neck of femur fracture; NOF). This finding provides the opportunity to characterise the functional effects of SOD2 downregulation in OA in the context of oxidative damage

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Honn, Marie. "The oxidative stress response of Francisella tularensis." Doctoral thesis, Umeå universitet, Klinisk bakteriologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-115635.

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Francisella tularensis is capable of infecting numerous cell types, including professional phagocytes. Upon phagocytosis, F. tularensis resides within the phagosome before escaping into the cytosol to replicate. Phagocytes constitute a hostile environment rich in ROS, which are employed as a means of killing pathogens. ROS interact with and disrupt the function of vital molecules such as DNA, proteins and bacterial structures. Iron potentiates the danger of ROS through the Fenton reaction where ferrous iron reduces H2O2 causing the formation of highly reactive hydroxyl radicals and anions. Low

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Al, Jothery Aqeel Handil Tarish. "Lactation and oxidative stress in small mammals." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=215095.

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During peak lactation female mammals reach a limit in their maximal sustained energy intake (SusEI). The causes of such limits is disputed. In this thesis, I examined the causes of the limits on SusEI at peak lactation, and then explored the consequences of such limits for reproductive performance. Finally I tested a possible physiological mechanism that may underpin the trade-off between reproduction and somatic protection (the oxidative stress theory). To answer these questions, I studied reproductive performance and oxidative stress in two lines of mice previously selected for high and low

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Dewar, Mairead. "Oxidative stress and cardiovascular ageing in diabetes." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/29910.

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Oxidative stress is thought to be elevated in diabetes as a consequence of hyperglycaemia. This thesis investigates oxidative DNA damage in diabetes, which may contribute to accelerated vascular ageing. Telomeric and mitochondrial DNA are two areas of the genome that may be more susceptible to oxidative stress and were therefore investigated.;51 patients with diabetes (aged 31-78 years) and 101 healthy controls (aged 19-75 years) were recruited. 51 of the controls were age- and sex-matched to be patient group. For both populations physiological profiles were obtained and pulse wave velocity (P

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Mota, Martorell Natàlia. "Oxidative stress homeostasis and longevity in mammals." Doctoral thesis, Universitat de Lleida, 2021. http://hdl.handle.net/10803/672775.

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Les espècies més longeves han evolucionat disminuint la producció endògena d’espècies reactives d’oxigen i proveint-se d’estructures resistents a la oxidació. Per tant, aquelles espècies que viuen més gaudeixen de mitocòndries metabòlicament més eficients i estructuralment més estables. De fet, característiques fenotípiques de la longevitat inclouen la reducció del contingut del complex I i dels aminoàcids sulfurats. Aleshores, l’activitat de determinades vies de senyalització intracel·lulars juga un paper clau regulant l’expressió de gens associats a un fenotip longeu. En aquest context, aqu

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Howbrook, David. "Development of an oxidative stress-responsive biosensor." Thesis, University of Surrey, 2000. http://epubs.surrey.ac.uk/844280/.

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The promoter region of the katG gene of Escherichia coli has been fused to two reporter genes GFPuv, encoding green fluorescent protein derived from Aequorea victoria and luxCDABE, encoding bacterial luciferase, from Photorhadbus luminescens to compare the qualities of these two reporters in microbial biosensor applications. In Escherichia coli both reporter systems produce stable signals. The lux construct was more sensitive at lower concentrations of hydrogen peroxide and the response time was shorter when compared with GFPuv. The latter, however, was better able to sense oxidative stress at

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Babintseva, A. G. "Oxidative Stress and Neonatal Acute Kidney Injury." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19793.

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SENFT, ALBERT PAUL. "AROMATIC HYDROCARBON RECEPTOR-DEPENDENT MITOCHONDRIAL OXIDATIVE STRESS." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1016461170.

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