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1

Knight, Annie Rose. "Measurement of nitric oxide metabolites and protein nitration in healthy and inflammatory human tissues and bio-fluids." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/25578.

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The central thesis of this project is that damage caused by reactive nitrogen species, e.g. 3-nitrotyrosine (Tyr-NO2), constitutes a marker of disease progression/severity. A new sensitive electrochemiluminescence ELISA was optimised and validated for Tyr-NO2 measurement, giving a lower limit of quantification of 0.04 nM BSA-NO2, intra- and inter-assay CVs of 6.5% and 11.3%, an average recovery of 106 ± 3% and average linearity 0.998 ± 0.001. Nitrative stress, carbonyl stress and C-reactive protein (CRP) concentrations were measured before and after major elective surgery. CRP measurements con
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2

Frost, Matthew Thomas. "The measurement of 3 nitrotyrosine in biological samples and its application to the assessment of protein nitration in disease." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249697.

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3

Sundaresan, Abaya Meenakshi. "Oil palm phenolics suppresses oxidative stress and inflammation." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/85775.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2013.<br>Page 122 blank Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Water-soluble Oil Palm Phenolics (OPP), derived from Elaeis guineensis, contains a unique blend of plant phenolics. Recent cell and animal studies have demonstrated positive health benefits in a number of different organ systems, with almost no noticeable side effects. Its efficacy and non-toxicity may be in large part due to several active polyphenolic ingredients, rather than a single one. In this w
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4

Swennen, Els Louise Rita. "ATP as a modulator of inflammation and oxidative stress." [Maastricht] : Maastricht : Universitaire Pers Maastricht ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=8302.

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5

Palm, Maria. "Oxidative Stress, Angiogenesis and Inflammation in Normal Pregnancy and Postpartum." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171165.

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The aims were to investigate oxidative stress (I), angiogenesis (II) and inflammation (III-IV) in healthy women during pregnancy and postpartum. Oxidative stress was estimated by measurement of 8-iso-PGF2α and the antioxidants α- and γ-tocopherol. The angiogenic factors PlGF, VEGF-A and the antiangiogenic factor sFlt1 were measured to estimate angiogenesis. PTX3, IL-6, TNF-α and a PGF2α metabolite were measured to estimate inflammation. Out of 52 included women, 15 had minor pregnancy complications and 37 were classified as normal. In study III data from all 52 women were used. For the other s
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6

McNeil, Kathryn Suzanne. "Nitrosative and oxidative stress in Nippostrongylus brasiliensis induced pulmonary inflammation." Thesis, Edinburgh Napier University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312974.

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7

Dick, Colin Allister James. "The oxidative and pro-inflammatory effects of respirable particles in lung cells." Thesis, Edinburgh Napier University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341660.

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8

Massaccesi, Luca <1985&gt. "Role of Bioactive Components in Inflammation and Oxidative Stress in Vascular Endothelium." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7500/.

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An increasing number of scientific evidence supports the preventive value of dietary patterns that favor the consumption of plant food. Especially fruit, vegetables, grains and legumes; the correlation between the reduction of risk of chronic disease such as adherence to the Mediterranean diet is the most significant example. The central role of the endothelium in maintaining vascular homeostasis and the correlation between endothelial dysfunction and the development of cardiovascular diseases makes this tissue a primary target for dietary strategies aimed at cardiovascular diseases prevention
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9

Wong, Hoi-kin, and 黃凱健. "New factors that affect adrenomedullin expression." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/195971.

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ADM is a 52-amino acid peptide which carries out multiple biological functions in cardiovascular system such as vasodilation and hypotension, and is a prognostic marker for cardiovascular diseases. Recent studies show that its plasma level is elevated in diabetes, however the reason and significance for such an increase has not been understood. Recent research has proposed that inflammation and oxidative stress both contribute to the pathogenesis of diabetes. If ADM is a marker in diabetes, it is possible that ADM is regulated by these two mechanisms, and so this project aims to investigate ho
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10

Hälldin, Jonas. "Oxidative stress and alterations in the mammalian iron metabolism : a study on iron, inflammation, oxidative stress and neurodegeneration in cellular model systems /." Stockholm : Department of Neurochemistry, Stockholm University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7037.

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11

Norton, Rosemary. "Effects of vitamin D on inflammation and oxidative stress in airway epithelial cells." Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/41410/.

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Chronic obstructive pulmonary disease (COPD) is a multifactorial and systemic disease driven by inflammation and oxidative stress, predominantly caused by smoking, but exacerbated by infection and pollution. Current therapies aim to treat specific aspects of the disease and/or symptoms rather than the disease as a whole. Vitamin D, more commonly known for its importance in calcium and phosphorus homeostasis, has now been established as an important immunomodulatory agent. Recent studies have shown vitamin D deficiency to be associated with reduced lung function and COPD disease severity. Equal
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12

Cheng, Zhong Jian. "Angiotensin II induced inflammation and vascular dysfunction : role of oxidative stress and cyclooxygenase." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/biola/vk/cheng/.

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13

Wadley, Alex James. "Exploring changes in markers of oxidative stress and inflammation in response to exercise." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5053/.

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Oxidative stress and inflammation are two reciprocally linked processes that characterise many disease states, but can also transiently increase in response to a range of stimuli, including exercise, to initiate adaptation. This thesis presents novel data indicating that oxidative stress did not increase in response to an acute mental arithmetic challenge, under resting conditions or experimentally induced high baseline inflammation. In the context of exercise, chapters 3, 4 and 5 support previous work that markers of plasma and peripheral blood mononuclear cell (PBMC) oxidative stress increas
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14

Khan, Younis. "The role of NF-κB p65 and Brd4 in oxidative stress driven inflammation". Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14702.

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Chronic obstructive pulmonary disease (COPD) is caused by prolonged cigarette smoke (CS) exposure. Increased oxidative stress produced by elevated oxidants, derived from cells and CS, or reduced anti-oxidant response is reported in COPD patients. Chronic inflammation is another key characteristic of COPD which persists long after smoking cessation. This suggests that oxidative stress may affect the course of inflammatory gene expression through changes in epigenetic modifications such as DNA and histone methylation and histone acetylation. Hydrogen peroxide (H2O2) is one of many oxidants repor
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15

Pringle, Andrea. "Phenotypic and functional characteristics of epithelial cells and macrophages in lung inflammation." Thesis, Edinburgh Napier University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342087.

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16

Andreae, Mary Christine. "Value of Raisins for Reduction of Oxidative Stress, Endothelial Dysfunction, and Inflammation in Obesity." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/34102.

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This study investigated the effects of daily consumption of Thompson seedless raisins on markers of inflammation, oxidative stress and endothelial activation in response to an acute high-fat meal in obese individuals. Seventeen overweight men and women consumed raisins or placebo (264 kcal/d) for 14 d in a randomized cross-over design while following a low-flavonoid, weight-maintenance diet. Four high-fat (53% fat) meals were consumed with the respective treatment pre and post interventions. Measures at fasting, and 2, 3 and 4 hours postprandial included markers of oxidative stress (urinary
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17

Kendig, Eric Lee. "Oxidative stress and inflammation as therapeutic targets of high-fat diet-induced metabolic diseases." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242844513.

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18

Botta, Amy. "Glutathione Dysregulation, Cardiac Oxidative Stress, and Inflammation during n-6 Polyunsaturated Fatty Acid Overload." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/62283.

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Historically dietary saturated fats were blamed for cardiovascular disease (CVD). However, lowering dietary saturated fats did not curb CVD rates and instead detrimental roles of n-6 polyunsaturated fatty acid (n-6 PUFA) which was used to substitute saturated fats have come to the forefront. My objective was to identify mechanisms leading to dietary n-6 PUFA induced CVDs using mice and cell models. Here isocaloric diets rich in n-6 PUFA or monounsaturated fatty acids (MUFA) were used in vivo or cardiac cells like cardiomyocytes and fibroblasts were incubated with n-6 PUFA or MUFA in vitro. We
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Maskiny, Charbel Farid. "Inflammatory response and oxidative stress in rats selected for intrinsic acrobic endurance capacity." Connect to full text in OhioLINK ETD Center, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1180467082.

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Thesis (M.S.)--University of Toledo, 2007.<br>"In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 46-54.
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20

Hallow, Karen Melissa. "Relationships between Mechanical Stress and Markers of Inflammation in Diseased Human Coronary Arteries." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/16211.

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Rupture of atherosclerotic plaque is one of the primary causes of death due to cardiovascular disease. The factors directing plaque progression to instability are poorly understood. It is well-known that arteries respond to changes in mechanical stress by remodeling, and that remodeling is mediated by the inflammatory response. Studies have shown that both mechanical stress and markers of inflammation are increased in the fibrous cap and shoulder regions of plaque, where rupture most often occurs. In this study we hypothesized that there are spatial relationships between the local mechanical e
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21

McGeoch, Susan Christina. "Effect of oats on post-prandial glycaemia, inflammation and oxidative stress in type 2 diabetes." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158362.

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Acute post-prandial hyperglycaemia may trigger acute increases in systemic inflammation and oxidative stress, potential risk factors for cardiovascular disease. We aimed to investigate the effect of both an oat-rich diet and standard dietary advice on glycaemic control, post-prandial glycaemia, inflammation and oxidative stress in volunteers with diet-managed type 2 diabetes. Method In a randomised cross-over design 30 volunteers with type 2 diabetes followed for two 8 week periods either an oat-rich diet or a control diet based on standard dietary advice. Volunteers attended at baseline, week
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22

Bourgeois, Marie Meagher. "Gender and Cocaine Use Influence the Expression of Urinary Markers of Inflammation and Oxidative Stress." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3572.

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The purpose of this study was to investigate whether or not gender differences may be present in the expression of a number of urinary proteins which may serve as markers of inflammation and oxidative stress. Males and females have different patterns of illness and different life spans, suggesting basic biological traits exert significant control on the incidence of rhabdomyolysis, renal failure, atherosclerosis, myocardial ischemia, myocardial contraction band formation, autoimmune disorders and general inflammatory diseases. Men are at greater risk for cardiovascular disease; however women,
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23

Miller, Rebecca Louise. "The mechanism for paraquat toxicity involves oxidative stress and inflammation a model for Parkinson's disease /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4764.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2007" Includes bibliographical references.
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24

Saidely, Dalia. "Molecular analysis of inflammation, oxidative stress, and gastric carcinogenesis : signal transduction and gene expression changes." Thesis, Swansea University, 2008. https://cronfa.swan.ac.uk/Record/cronfa42638.

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Long term gastric inflammation (chronic gastritis) and its coupled tumourigenic inflammatory milieu (Reactive Oxygen/ Nitrogen Species (RO/NS), cytokines, etc.) is seen to impact cells at several levels, and as such is seen to be a major driving force of gastric carcinogenesis. The goal of this investigation was to examine the impact of inflammation, with a special focus on the oxidative stress component, on signal transduction and gene expression changes in gastric epithelial cells at the levels of Mitogen Activated Protein Kinase (MAPK) and Nuclear Factor Kappa-B (NFkappaB) pathways and down
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25

Peairs, Abigail Desiree. "The Effects of Macronutrient Composition on Oxidative Stress and Inflammation in Overweight and Obese Humans." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/29027.

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Two thirds of American adults are overweight and almost half of those qualify as obese. Obesity independently increases risk for cardiovascular disease (CVD), type II diabetes (T2D), and hypertension; thus, strategies to reduce risk in this population are desperately needed. Oxidative stress and inflammation are two perpetuators of these chronic diseases that are often elevated in obesity. Interventions that target reductions in oxidative stress and inflammation may help to reduce co-morbidities associated with obesity. Weight loss is shown to reduce oxidative stress and inflammation. How
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26

Kim, Paul Hyunchul. "Role of 5-Lipoxygenase in Interleukin-4-Induced Oxidative Stress and Inflammation in Vascular Endothelium." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/31798.

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Cardiovascular disease (CVD) including atherosclerosis is the leading cause of illness and death in the United States. The American Heart Association indicated that an estimated 81,100,000 American adults have one or more types of CVD and the estimated direct and indirect cost of CVD for 2010 is $503.2 billion, which is $27.9 billion more than last year. Although the exact cause of this disease remains unsolved, previous studies have demonstrated that pro-oxidative and pro-inflammatory pathways in vascular endothelium play a critical role in early pathological events of atherosclerosis. Howeve
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27

Kurti, Stephanie P. "The impact of lifestyle, age, and sex on systemic and airway inflammation and oxidative stress." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/35294.

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Doctor of Philosophy<br>Department of Kinesiology<br>Craig A. Harms<br>The overall aim of this dissertation was to determine the impact of lifestyle (i.e. habitual and acute physical activity and diet), age, and sex on systemic and airway inflammation and oxidative stress. In study 1 (Chapter 2) we examined the impact of habitual physical activity level on the post-prandial airway inflammatory response following an acute bout of moderate intensity exercise. Results indicated that the mean exhaled nitric oxide (eNO; marker of airway inflammation) response increased for all groups at two hours p
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Soileau, Jason. "Evaluation of a Sport Supplement on Performance, Buffering Capacity, Muscle Damage, Oxidative Stress, and Inflammation." Thesis, University of Louisiana at Lafayette, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10244210.

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<p> This thesis investigated the total effects of a sport supplement on performance, buffering capacity, muscle damage, oxidative stress, and inflammation. Sixteen males, ages 24-33, participated. Each subject visited the lab three times over the course of thirty days, completing a graded cycling test on three of the occasions and one high intensity sprint test on two of the visits. The second and third visits including venous blood draws intended for analysis of various biological markers as well as ammonia content. Lactate levels were analyzed and recorded on these visits as well. In double-
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Leung, Joanne Yuen Ting. "Cardiovascular function in rat models of diabetes – the roles of hyperglycemia, inflammation and oxidative stress." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52724.

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Diabetes increases the risk of cardiovascular disease and mortality in humans. Although many diabetes-related studies have been conducted in recent years, the underlying pathogenesis still remains unclear. The aim of this thesis was to investigate if vascular and cardiac contractile dysfunction in rat models of streptozotocin-induced type 1 and fructose-streptozotocin-induced type 2 diabetes are associated with hyperglycemia, inflammation and oxidative stress, as these factors have been linked to the development of cardiovascular abnormalities in diabetes. Cardiovascular function was assessed
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Le, Brocq Michelle Louise. "Advanced glycation end product precursors in diabetes : a crucial link between oxidative stress and inflammation?" Thesis, University of the Highlands and Islands, 2010. https://pure.uhi.ac.uk/portal/en/studentthesis/advanced-glycation-end-product-precursors-in-diabetes(53be96a1-0fe3-4fc7-88c7-2bf2b4421d27).html.

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Advanced glycated end-products (AGEs) are a heterogenous group of compounds formed through the Maillard reaction. During AGE formation, reactive α-dicarbonyls are formed, such as glyoxal (GO) and methylglyoxal (MG). These α-dicarbonyls are present at elevated concentrations in diabetes, and are frequently implicated in the initiation and progression of diabetic complications. Previous research has linked α-dicarbonyls with formation of reactive oxygen species (ROS) and inflammation. However, much of the prior work has been conducted using concentrations of α-dicarbonyls that are substantially
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Flavall, Elizabeth A. "Localisation of antioxidants and oxidative markers within the atherosclerotic plaque." Thesis, University of Canterbury. Biological Sciences, 2008. http://hdl.handle.net/10092/1941.

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Atherosclerosis is a complex inflammatory disease in which oxidative stress is a major protagonist in the development and progression of the atherosclerotic plaque. All biochemical analysis studies of plaque over the past fifteen years have been carried out on whole plaque with no attempt to localise sites of differing biochemical conditions. This study set out to identify in oxidation levels and inflammatory markers in relation to spatial localisation within the plaque. Advanced plaque samples removed during endarectomy were obtained from the Christchurch Hospital Department of surgery and we
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Poljak, Anne Medical Sciences Faculty of Medicine UNSW. "Oxidative, inflammatory and vascular factors in Alzheimer's disease." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/41273.

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In spite of impressive recent progress, the aetiopathogenesis of Alzheimer’s disease (AD) remains incompletely understood. The distinctive neuropathological features of AD, in particular the plaques and tangles, have been the particular focus of most aetiological theories. It is well accepted that AD is a multifactorial disease, with alterations to a variety of brain structures and cell types, including neurons, glia and the brain vasculature. Studies of risk factors have revealed a diversity of genetic variables that interact with health, diet and lifestyle-related factors in the causation o
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Kouadri, Amal. "Le cuivre influence le stress oxydatif et l'inflammation associés à la mucoviscidose et régule la barrière jonctionnelle bronchique saine via la protéine prion cellulaire (PrPC)." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV080/document.

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La mucoviscidose est une maladie génétique, autosomale et récessive. Elle est caractérisée par une inflammation précoce des voies aériennes observée en absence de toute infection bactérienne, virale ou fongique. Aujourd’hui, l’origine de cette inflammation précoce reste très discutée. Plusieurs études mettent en avant la participation du stress oxydatif, une composante pathologique majeure de la mucoviscidose. Cependant, le lien entre le stress oxydatif et l’inflammation dans un contexte mucoviscidosique reste à démontrer.Mon projet de thèse a porté sur la caractérisation du rôle du stress oxy
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Luciano, Mateo Fedra Nicaury. "The role of chemokine (c-c motif) ligand 2 in inflammation, oxidative stress, aging and metabolism." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/667564.

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El metabolisme i el sistema immunològic estan estretament relacionats i les seves interaccions juguen un paper important en l'homeòstasi sistèmica. L'activació, proliferació, diferenciació i polarització de les cèl·lules immunitàries representen un important estrès metabòlic, que pot comprometre el metabolisme cel·lular, l'homeòstasi i les necessitats energètiques. Aquestes condicions poden promoure l'estrès metabòlic crònic i les anomalies metabòliques en patologies no immunes. No obstant això, encara no queda clar com aquests canvis en el perfil immunològic afecten el metabolisme sistèmic. C
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35

Helmersson, Johanna. "Prostaglandins and Isoprostanes in Relation to Risk Factors for Atherosclerosis : Role of Inflammation and Oxidative Stress." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4803.

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Orlandi, M. "The impact of periodontal infection and its treatment on systemic inflammation, oxidative stress and endothelium integrity." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1515839/.

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Background: Periodontitis (PD) is a chronic inflammatory disease. The low-grade systemic inflammatory and oxidative status seems to be a plausible mechanism to explain the relationship between cardiovascular disease (CVD) and PD. The aim of this PhD was to investigate the association between PD and its treatment and the human vascular homeostasis. Methods: 4 studies were conducted: 1) a systematic review and meta-analysis of cases with PD and controls to assess the differences in intima-media thickness and endothelial function between cases and controls, 2) a Randomized controlled trial invest
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Barros, Marcos AurÃlio Pessoa. "L-alanyl glutamine preconditioning on oxidative stress and inflammation in graft patients who underwent liver transplantation." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13446.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>In liver transplantation, ischemia/reperfusion may cause serious injury to the graft. The aim of this study was to evaluate the effects of preconditioning with L-alanyl-glutamine in graft protection in patients undergoing liver transplantation. 33 patients undergoing liver transplantation at the Walter CantÃdio University Hospital (HUWC) of the Federal University of Cearà (UFC), from 05/22/13 to 12/11/2013 were evaluated. A prospective, double-blind, divided into two groups was performed. In glutamine group was administered 50 g of
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Thomas-Ahner, Jennifer Marie. "Gender differences in UVB induced cutaneous inflammation and skin carcinogenesis." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1179949864.

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Wanjiku, Samuel Mburu. "Impact of inflammation-induced oxidative stress on the integrity of immuno-haematopoietic cells and potential ameliorating interventions in an in vitro HIV model." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/95467.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Chronic inflammation and immune activation are hallmarks of HIV infection, resulting in chronic oxidative stress with over-utilization of antioxidant defences, which may contribute to the loss of immune cells and faster disease progression. Low levels of antioxidants in HIV- infected individuals have been associated with frequent opportunistic infections and an increased risk of mortality. HIV infection is also associated with on-going and aberrant activation of both the innate and adaptive immune systems. An important aspect of
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Ko, Soyoung. "Androgen receptor expression and activity roles of inflammation, age-induced oxidative stress, and epigenetic modifications : a dissertation /." San Antonio : UTHSC, 2009. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=42&CISOBOX=1&REC=2.

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Pinto, NatÃlia BitÃ. "AvaliaÃÃo da atividade neuroprotetora do extrato padronizado de Camellia sinensis e de seus princÃpios bioativos: envolvimento de aÃÃes anti-inflamatÃrias e antioxidantes." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15024.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>A doenÃa de Parkinson (DP) à uma desordem neurodegenerativa caracterizada pela destruiÃÃo dos neurÃnios nigroestriatais dopaminÃrgicos. O tratamento atual à apenas sintomÃtico e, atà o presente momento, nÃo existem drogas capazes de inibir a degeneraÃÃo neuronal. Assim à grande a procura por agentes neuroprotetores que possam impedir ou retardar a progressÃo desta doenÃa. A Camellia sinensis à uma espÃcie da famÃlia Theaceae, popularmente conhecida como chÃ-verde (CV). VÃrios estudos tÃm demonstrado os efeitos benÃficos desta plant
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Abbey, Elizabeth Lea. "The Effects of Carbohydrate and Quercetin on Team Sport Athletic Performance and Exercise-Induced Inflammation and Oxidative Stress." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/26759.

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Over 270 million people play soccer worldwide, and its popularity grows every day. In team sport exercise, fatigue may result from numerous factors including limited fuel, depleted energy stores and production of compounds that promote an inflammatory response. While inflammation is an essential mechanism for repairing damaged muscle tissue with exercise, prolonged inflammation leads to increased production of reactive oxygen species that can damage cell membranes, muscle, and signaling proteins. To prevent this response and improve performance, athletes are increasingly looking to nutritio
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Lau, Kwok-wai, and 劉國威. "The involvement of serotoninergic system in cigarette smoke-induced oxidative stress and inflammation: relevantto chronic obstructive pulmonary disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47869616.

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Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD) with chronic airway inflammation as a key feature. Currently, no effective treatment can reduce the protracted inflammation in the lung of COPD. Further research on the inflammatory mechanisms would therefore be important in determining new potential therapeutic targets in COPD. Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that plays an important role in pulmonary functions and inflammatory responses. The serotoninergic system including serotonin trans
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Deaton, Christopher Mark David. "Systemic and pulmonary antioxidant status oxidative stress in the horse : effects of airway inflammation, ozone and exercise." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407491.

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45

Manney, Sarah. "Studies of markers of inflammation and oxidative stress in a newly developed exhaled breath condensate collecting system." Thesis, University of Birmingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522005.

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Exhaled breath condensate (EBC) collection, is a non-invasive method of measuring airways inflammation. This thesis records the development of a portable and reusable EBC collection system and its use in health and disease to determine ranges of EBC nitrate and nitrite (NOx) and glutathione (GSH) concentration; additionally the effect of direct and ambient air pollution exposure on NOx and GSH in EBC and nasal lavage NALF) was examined. Preliminary experiments revealed a collection time of 15 minutes with a system employing Teflon® tubes provided mean EBC volumes of 1.94±0.58m1. EBC NOx found
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46

Liu, Yu, and 刘宇. "Nitric oxide production, oxidative stress, and inflammation in the rat adrenal medulla during chronic and intermittent hypoxia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/198929.

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Adrenal gland, as an important effector tissue of the sympathetic nervous system, has critical roles in cardiovascular system under both chronic hypoxia (CH) and intermittent hypoxia (IH) conditions. Nitric oxide (NO), synthesized by nitric oxide synthases (NOS), is the most important intracellular signaling molecule, as well as free radical in response to hypoxia. Yet the regulation and effects of endogenous NO production mediated in the adrenal medulla induced by hypoxia remains largely unknown. We first studied how endogenous NO production were regulated by different NOS in rat adrenal med
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47

Thomas-Ahner, Jennifer M. "Gender differences in UVB induced cutaneous inflammation and skin carcinogenesis." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1179949864.

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48

NAGATA, KOHZO, TOYOAKI MUROHARA, XIAN WU CHENG, et al. "Glucocorticoids Activate Cardiac Mineralocorticoid Receptors in Adrenalectomized Dahl Salt- Sensitive Rats." Nagoya University School of Medicine, 2014. http://hdl.handle.net/2237/19484.

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49

Santos, Elba LÃcia Wanderley dos. "Efeitos da Acupuntura, Eletroacupuntura e Metformina Sobre o Estresse Oxidativo, InflamaÃÃo e Glicemia em Ratas Sadias Submetidas a EstÃmulo EstrogÃnico." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9040.

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CoordenaÃÃo de AperfeiÃoamento de NÃvel Superior<br>O desempenho fisiolÃgico da atividade celular requer um equilÃbrio entre a produÃÃo de espÃcies de radicais livres e a sua desativaÃÃo por agentes reguladores e protetores. Quando esse equilÃbrio à quebrado, surge o estresse oxidativo. Diversos estudos experimentais utilizando estrÃgenos para a induÃÃo de distÃrbios ovarianos e metabÃlicos, com destaque para a SÃndrome dos OvÃrios PolicÃsticos (SOP), estÃo disponÃveis na literatura cientÃfica. A Metformina (MTF) à um anti-hiperglicemiante, frequentemente utilizado para tratamento da SOP, perm
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50

Rund, Katharina M. [Verfasser]. "Development of Analytical Methods to Investigate the Formation of Oxylipins during Oxidative Stress and Inflammation / Katharina M. Rund." Wuppertal : Universitätsbibliothek Wuppertal, 2020. http://d-nb.info/1221970712/34.

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