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Journal articles on the topic 'Oxidative stress ; nitrotyrosine ; inflammation'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Matilla, Lara, Jaime Ibarrola, Vanessa Arrieta, et al. "Soluble ST2 promotes oxidative stress and inflammation in cardiac fibroblasts: an in vitro and in vivo study in aortic stenosis." Clinical Science 133, no. 14 (2019): 1537–48. http://dx.doi.org/10.1042/cs20190475.

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Abstract Background: Soluble ST2 (interleukin 1 receptor-like 1) (sST2) is involved in inflammatory diseases and increased in heart failure (HF). We herein investigated sST2 effects on oxidative stress and inflammation in human cardiac fibroblasts and its pathological role in human aortic stenosis (AS). Methods and results: Using proteomics and immunodetection approaches, we have identified that sST2 down-regulated mitofusin-1 (MFN-1), a protein involved in mitochondrial fusion, in human cardiac fibroblasts. In parallel, sST2 increased nitrotyrosine, protein oxidation and peroxide production.

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Beauséjour, Annie, Véronique Houde, Karine Bibeau, Rébecca Gaudet, Jean St-Louis, and Michèle Brochu. "Renal and cardiac oxidative/nitrosative stress in salt-loaded pregnant rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 293, no. 4 (2007): R1657—R1665. http://dx.doi.org/10.1152/ajpregu.00090.2007.

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Sodium supplementation given for 1 wk to nonpregnant rats induces changes that are adequate to maintain renal and circulatory homeostasis as well as arterial blood pressure. However, in pregnant rats, proteinuria, fetal growth restriction, and placental oxidative stress are observed. Moreover, the decrease in blood pressure and expansion of circulatory volume, normally associated with pregnancy, are prevented by high-sodium intake. We hypothesized that, in these pregnant rats, a loss of the balance between prooxidation and antioxidation, particularly in kidneys and heart, disturbs the normal c

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Lochhead, Jeffrey J., Gwen McCaffrey, Lucy Sanchez-Covarrubias, et al. "Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain." American Journal of Physiology-Heart and Circulatory Physiology 302, no. 3 (2012): H582—H593. http://dx.doi.org/10.1152/ajpheart.00889.2011.

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Our laboratory has shown that λ-carrageenan-induced peripheral inflammatory pain (CIP) can alter tight junction (TJ) protein expression and/or assembly leading to changes in blood-brain barrier xenobiotic permeability. However, the role of reactive oxygen species (ROS) and subsequent oxidative stress during CIP is unknown. ROS (i.e., superoxide) are known to cause cellular damage in response to pain/inflammation. Therefore, we examined oxidative stress-associated effects at the blood-brain barrier (BBB) in CIP rats. During CIP, increased staining of nitrosylated proteins was detected in hind p

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Anselmo, Natassia Alberici, Leticia Colombo Paskakulis, Renata Correia Garcias, et al. "Prior intake of Brazil nuts attenuates renal injury induced by ischemia and reperfusion." Brazilian Journal of Nephrology 40, no. 1 (2018): 10–17. http://dx.doi.org/10.1590/1678-46a85-jbn-3819.

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ABSTRACT Introduction: Ischemia-reperfusion (IR) injury results from inflammation and oxidative stress, among other factors. Because of its anti-inflammatory and antioxidant properties, the Brazil nut (BN) might attenuate IR renal injury. Objective: The aim of the present study was to investigate whether the intake of BN prevents or reduces IR kidney injury and inflammation, improving renal function and decreasing oxidative stress. Methods: Male Wistar rats were distributed into six groups (N=6/group): SHAM (control), SHAM treated with 75 or 150 mg of BN, IR, and IR treated with 75 or 150 mg o

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Tapia, Edilia, Dolores J. Sánchez-González, Omar N. Medina-Campos, et al. "Treatment with pyrrolidine dithiocarbamate improves proteinuria, oxidative stress, and glomerular hypertension in overload proteinuria." American Journal of Physiology-Renal Physiology 295, no. 5 (2008): F1431—F1439. http://dx.doi.org/10.1152/ajprenal.90201.2008.

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We evaluated whether the blockade of the proinflammatory transcription factor NF-κB would modify the oxidative stress, inflammation, and structural and hemodynamic alterations found in the kidney as a result of massive proteinuria. Twenty male Sprague-Dawley rats were injected with 2 g of BSA intraperitoneally daily for 2 wk. Ten of them received in addition the inhibitor of NF-κB activation pyrrolidine dithiocarbamate (PDTC; 200 mg·kg−1·day−1 sc) and the rest received vehicle. Seven rats that received intraperitoneal saline were used as controls. Glomerular hemodynamics were studied after 14

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Di Stefano, Antonino, Mauro Maniscalco, Bruno Balbi, and Fabio L. M. Ricciardolo. "Oxidative and Nitrosative Stress in the Pathogenesis of Obstructive Lung Diseases of Increasing Severity." Current Medicinal Chemistry 27, no. 42 (2020): 7149–58. http://dx.doi.org/10.2174/0929867327666200604165451.

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The imbalance between increased oxidative agents and antioxidant defence mechanisms is central in the pathogenesis of obstructive lung diseases such as asthma and COPD. In these patients, there are increased levels of reactive oxygen species. Superoxide anions (O<sub>2</sub> -), Hydrogen Peroxide (H<sub>2</sub>O<sub>2</sub>) and hydroxyl radicals (•OH) are critical for the formation of further cytotoxic radicals in the bronchi and lung parenchyma. Chronic inflammation, partly induced by oxidative stress, can further increase the oxidant burden through activa

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Bouch, Sheena, Megan O'Reilly, Richard Harding, and Foula Sozo. "Neonatal exposure to mild hyperoxia causes persistent increases in oxidative stress and immune cells in the lungs of mice without altering lung structure." American Journal of Physiology-Lung Cellular and Molecular Physiology 309, no. 5 (2015): L488—L496. http://dx.doi.org/10.1152/ajplung.00359.2014.

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Preterm infants often require supplemental oxygen due to lung immaturity, but hyperoxia can contribute to an increased risk of respiratory illness later in life. Our aim was to compare the effects of mild and moderate levels of neonatal hyperoxia on markers of pulmonary oxidative stress and inflammation and on lung architecture; both immediate and persistent effects were assessed. Neonatal mice (C57BL6/J) were raised in either room air (21% O2), mild (40% O2), or moderate (65% O2) hyperoxia from birth until postnatal day 7 (P7d). The mice were killed at either P7d (immediate effects) or lived

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Li, Fang, Fangfang Lang, Huilin Zhang, et al. "Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/2302896.

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Apigenin, a component in daily diets, demonstrates antioxidant and anti-inflammatory properties. Here, we intended to explore the mechanism of apigenin-mediated endotoxin-induced myocardial injury and its role in the interplay among inflammation, oxidative stress, and autophagy. In our lipopolysaccharide- (LPS-) induced myocardial injury model, apigenin ameliorated cardiac injury (lactate dehydrogenase (LDH) and creatine kinase (CK)), cell death (TUNEL staining, DNA fragmentation, and PARP activity), and tissue damage (cardiac troponin I (cTnI) and cardiac myosin light chain-1 (cMLC1)) and imp

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Lv, Chang-Cheng, Man-Li Xia, Shu-Juan Shu, Fei Chen, and Li-Shan Jiang. "Attenuation of Remifentanil-Induced Hyperalgesia by Betulinic Acid Associates with Inhibiting Oxidative Stress and Inflammation in Spinal Dorsal Horn." Pharmacology 102, no. 5-6 (2018): 300–306. http://dx.doi.org/10.1159/000493144.

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Remifentanil-induced hyperalgesia (RIH) is known to be associated with oxidative stress and inflammation. Betulinic acid (BA) was reported to reduce visceral pain owing to its anti-oxidative and anti-inflammatory potential. Here, we explored whether BA can attenuate RIH through inhibiting oxidative stress and inflammation in spinal dorsal horn. Sprague-Dawley rats were randomly divided into 4 groups: Control, Incision, RIH, and RIH pre-treated with BA. After pretreated with BA (25 mg/kg, i.g.) for 7 days, rats were subcutaneously infused with remifentanil (40 μg/kg) for 30 min during right pl

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Zingarelli, B., C. Szabó, and A. L. Salzman. "Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase." Gut 45, no. 2 (1999): 199–209. http://dx.doi.org/10.1136/gut.45.2.199.

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BACKGROUNDOxidative and nitrosative stress have been implicated in the pathogenesis of inflammatory bowel diseases.AIMSTo study the role of nitric oxide (NO) derived from inducible NO synthase (iNOS) in an experimental model of murine enterocolitis.METHODSTrinitrobenzene sulphonic acid (TNBS) was instilled per rectum to induce a lethal colitis in iNOS deficient mice and in wild type controls. The distal colon was evaluated for histological evidence of inflammation, iNOS expression and activity, tyrosine nitration and malondialdehyde formation (as indexes of nitrosative and oxidative stress), m

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Liu, Wenjuan, Wei Gong, Min He, et al. "Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats." Journal of Diabetes Research 2018 (October 14, 2018): 1–13. http://dx.doi.org/10.1155/2018/9232065.

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Spironolactone (SPR) has been shown to protect diabetic cardiomyopathy (DCM), but the specific mechanisms are not fully understood. Here, we determined the cardioprotective role of SPR in diabetic mice and further explored the potential mechanisms in bothin vivoandin vitromodels. Streptozotocin- (STZ-) induced diabetic rats were used as the in vivo model. After the onset of diabetes, rats were treated with either SPR (STZ + SPR) or saline (STZ + NS) for 12 weeks; nondiabetic rats were used as controls (NDCs). In vitro, H9C2 cells were exposed to aldosterone, with or without SPR. Cardiac struct

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Gonzalez, Eric J., Abbey Peterson, Susan Malley, et al. "The Effects of Tempol on Cyclophosphamide-Induced Oxidative Stress in Rat Micturition Reflexes." Scientific World Journal 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/545048.

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We hypothesized that cyclophosphamide- (CYP-) induced cystitis results in oxidative stress and contributes to urinary bladder dysfunction. We determined (1) the expression of oxidative stress markers 3-nitrotyrosine (3-NT), reactive oxygen species (ROS)/reactive nitrogen species (RNS), inflammatory modulators, neuropeptides calcitonin gene-related peptide (CGRP), substance P (Sub P), and adenosine triphosphate (ATP) that contribute to the inflammatory process in the urinary tract and (2) the functional role of oxidative stress in urinary bladder dysfunction with an antioxidant, Tempol, (1 mM i

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Zhou, Shanshan, Yonggang Wang, Yi Tan, et al. "Deletion of Metallothionein Exacerbates Intermittent Hypoxia-Induced Oxidative and Inflammatory Injury in Aorta." Oxidative Medicine and Cellular Longevity 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/141053.

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The present study was to explore the effect of metallothionein (MT) on intermittent hypoxia (IH) induced aortic pathogenic changes. Markers of oxidative damages, inflammation, and vascular remodeling were observed by immunohistochemical staining after 3 days and 1, 3, and 8 weeks after IH exposures. Endogenous MT was induced after 3 days of IH but was significantly decreased after 8 weeks of IH. Compared with the wild-type mice, MT knock-out mice exhibited earlier and more severe pathogenic changes of oxidative damages, inflammatory responses, and cellular apoptosis, as indicated by the signif

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Annunziata, Giuseppe, Manuel Jimenez-García, Silvia Tejada, et al. "Grape Polyphenols Ameliorate Muscle Decline Reducing Oxidative Stress and Oxidative Damage in Aged Rats." Nutrients 12, no. 5 (2020): 1280. http://dx.doi.org/10.3390/nu12051280.

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A large number of studies have demonstrated the implication of oxidative stress (OxS) in the pathogenesis of ageing-related muscle decline and atrophy. The key mechanism is related to the OxS-induced production of free radicals, with the consequent increase in oxidative damage, resulting in affected muscle quality and strength. The present study aimed to evaluate the efficacy of a grape polyphenol-based nutraceutical formulation (Taurisolo®) in reducing the OxS in muscle of aged rats. A group of 16 aged (20 months) rats were orally administered with Taurisolo® (n = 8; 100 mg/kg Taurisolo®) or

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Fusco, Roberta, Rosalba Siracusa, Ramona D’Amico, et al. "Melatonin Plus Folic Acid Treatment Ameliorates Reserpine-Induced Fibromyalgia: An Evaluation of Pain, Oxidative Stress, and Inflammation." Antioxidants 8, no. 12 (2019): 628. http://dx.doi.org/10.3390/antiox8120628.

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Background: Fibromyalgia is a chronic condition characterized by increased sensory perception of pain, neuropathic/neurodegenerative modifications, oxidative, and nitrosative stress. An appropriate therapy is hard to find, and the currently used treatments are able to target only one of these aspects. Methods: The aim of this study is to investigate the beneficial effects of melatonin plus folic acid administration in a rat model of reserpine-induced fibromyalgia. Sprague–Dawley male rats were injected with 1 mg/kg of reserpine for three consecutive days and later administered with melatonin,

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Pereira, Domingos Magno Santos, Simone Aparecida Teixeira, Oscar Murillo, et al. "TRPV1 Contributes to Cerebral Malaria Severity and Mortality by Regulating Brain Inflammation." Oxidative Medicine and Cellular Longevity 2019 (May 16, 2019): 1–15. http://dx.doi.org/10.1155/2019/9451671.

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Transient receptor potential vanilloid 1 (TRPV1) is a Ca+2-permeable channel expressed on neuronal and nonneuronal cells, known as an oxidative stress sensor. It plays a protective role in bacterial infection, and recent findings indicate that this receptor modulates monocyte populations in mice with malaria; however, its role in cerebral malaria progression and outcome is unclear. By using TRPV1 wild-type (WT) and knockout (KO) mice, the importance of TRPV1 to this cerebral syndrome was investigated. Infection with Plasmodium berghei ANKA decreased TRPV1 expression in the brain. Mice lacking

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Vázquez-Medina, José Pablo, Jian-Quin Tao, Priyal Patel, et al. "Genetic inactivation of the phospholipase A2 activity of peroxiredoxin 6 in mice protects against LPS-induced acute lung injury." American Journal of Physiology-Lung Cellular and Molecular Physiology 316, no. 4 (2019): L656—L668. http://dx.doi.org/10.1152/ajplung.00344.2018.

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Peroxiredoxin 6 (Prdx6) is a multifunctional enzyme that serves important antioxidant roles by scavenging hydroperoxides and reducing peroxidized cell membranes. Prdx6 also plays a key role in cell signaling by activating the NADPH oxidase, type 2 (Nox2) through its acidic Ca2+-independent phospholipase A2 (aiPLA2) activity. Nox2 generation of O2·−, in addition to signaling, can contribute to oxidative stress and inflammation such as during sepsis-induced acute lung injury (ALI). To evaluate a possible role of Prdx6-aiPLA2 activity in the pathophysiology of ALI associated with a systemic insul

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Mazzoli, Arianna, Maria Stefania Spagnuolo, Martina Nazzaro, Cristina Gatto, Susanna Iossa, and Luisa Cigliano. "Fructose Removal from the Diet Reverses Inflammation, Mitochondrial Dysfunction, and Oxidative Stress in Hippocampus." Antioxidants 10, no. 3 (2021): 487. http://dx.doi.org/10.3390/antiox10030487.

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Young age is often characterized by high consumption of processed foods and fruit juices rich in fructose, which, besides inducing a tendency to become overweight, can promote alterations in brain function. The aim of this study was therefore to (a) clarify brain effects resulting from fructose consumption in juvenile age, a critical phase for brain development, and (b) verify whether these alterations can be rescued after removing fructose from the diet. Young rats were fed a fructose-rich or control diet for 3 weeks. Fructose-fed rats were then fed a control diet for a further 3 weeks. We ev

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Mak, I. Tong, Joanna J. Chmielinska, Christopher F. Spurney, William B. Weglicki, and Jay H. Kramer. "Combination ART-Induced Oxidative/Nitrosative Stress, Neurogenic Inflammation and Cardiac Dysfunction in HIV-1 Transgenic (Tg) Rats: Protection by Mg." International Journal of Molecular Sciences 19, no. 8 (2018): 2409. http://dx.doi.org/10.3390/ijms19082409.

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Chronic effects of a combination antiretroviral therapy (cART = tenofovir/emtricitatine + atazanavir/ritonavir) on systemic and cardiac oxidative stress/injury in HIV-1 transgenic (Tg) rats and protection by Mg-supplementation were assessed. cART (low doses) elicited no significant effects in normal rats, but induced time-dependent oxidative/nitrosative stresses: 2.64-fold increased plasma 8-isoprostane, 2.0-fold higher RBC oxidized glutathione (GSSG), 3.2-fold increased plasma 3-nitrotyrosine (NT), and 3-fold elevated basal neutrophil superoxide activity in Tg rats. Increased NT staining occu

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Buschmann, Katja, Julius Wrobel, Ryan Chaban, et al. "Body Mass Index (BMI) and Its Influence on the Cardiovascular and Operative Risk Profile in Coronary Artery Bypass Grafting Patients: Impact of Inflammation and Leptin." Oxidative Medicine and Cellular Longevity 2020 (June 24, 2020): 1–9. http://dx.doi.org/10.1155/2020/5724024.

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Background. Obesity is related to coronary artery disease (CAD) and worse outcomes in coronary artery bypass graft (CABG) patients. Adipose tissue itself is an endocrine organ that secretes many humoral mediators, such as adipokines, which can induce or reduce inflammation and oxidative stress. Objectives. We investigate the relationship between the body mass index (BMI), inflammation, and oxidative stress by measuring serum levels of leptin, interleukin-6, and 3-nitrotyrosine in CABG patients and correlate their levels to the cardiovascular and operative risk profiles. Methods and Results. 45

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White, Michel, Anique Ducharme, Reda Ibrahim, et al. "Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support." Clinical Science 110, no. 4 (2006): 483–89. http://dx.doi.org/10.1042/cs20050317.

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In the present study, we evaluated circulating pro-inflammatory mediators and markers of oxidative stress in patients with decompensated CHF (congestive heart failure) and assessed whether clinical recompensation by short-term inotropic therapy influences these parameters. Patients with worsening CHF (n=29, aged 61.9±2.7 years), NYHA (New York Heart Association) class III–IV, and left ventricular ejection fraction of 23.7±1.8% were studied. Controls comprised age-matched healthy volunteers (n=15; 54.1±3.2 years). Plasma levels of cytokines [IL (interleukin)-6 and IL-18], chemokines [MCP-1 (mon

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Helmstädter, Johanna, Karin Keppeler, Franziska Aust, et al. "GLP-1 Analog Liraglutide Improves Vascular Function in Polymicrobial Sepsis by Reduction of Oxidative Stress and Inflammation." Antioxidants 10, no. 8 (2021): 1175. http://dx.doi.org/10.3390/antiox10081175.

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Sepsis causes high mortality in the setting of septic shock. LEADER and other trials revealed cardioprotective and anti-inflammatory properties of glucagon-like peptide-1 (GLP-1) analogs like liraglutide (Lira). We previously demonstrated improved survival in lipopolysaccharide (LPS)-induced endotoxemia by inhibition of GLP-1 degradation. Here we investigate the effects of Lira in the polymicrobial sepsis model of cecal ligation and puncture (CLP). C57BL/6J mice were intraperitoneally injected with Lira (200 µg/kg/d; 3 days) and sepsis induced by CLP after one day of GLP-1 analog treatment. Su

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Campolo, Nicolás, Federico M. Issoglio, Darío A. Estrin, Silvina Bartesaghi, and Rafael Radi. "3-Nitrotyrosine and related derivatives in proteins: precursors, radical intermediates and impact in function." Essays in Biochemistry 64, no. 1 (2020): 111–33. http://dx.doi.org/10.1042/ebc20190052.

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Abstract Oxidative post-translational modification of proteins by molecular oxygen (O2)- and nitric oxide (•NO)-derived reactive species is a usual process that occurs in mammalian tissues under both physiological and pathological conditions and can exert either regulatory or cytotoxic effects. Although the side chain of several amino acids is prone to experience oxidative modifications, tyrosine residues are one of the preferred targets of one-electron oxidants, given the ability of their phenolic side chain to undergo reversible one-electron oxidation to the relatively stable tyrosyl radical

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Trocha, Małgorzata, Mariusz G. Fleszar, Paulina Fortuna, et al. "Sitagliptin Modulates Oxidative, Nitrative and Halogenative Stress and Inflammatory Response in Rat Model of Hepatic Ischemia-Reperfusion." Antioxidants 10, no. 8 (2021): 1168. http://dx.doi.org/10.3390/antiox10081168.

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A possibility of repurposing sitagliptin, a well-established antidiabetic drug, for alleviating injury caused by ischemia-reperfusion (IR) is being researched. The aim of this study was to shed some light on the molecular background of the protective activity of sitagliptin during hepatic IR. The expression and/or concentration of inflammation and oxidative stress-involved factors have been determined in rat liver homogenates using quantitative RT-PCR and Luminex® xMAP® technology and markers of nitrative and halogenative stress were quantified using targeted metabolomics (LC-MS/MS). Animals (

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Kan, Wen-Hong, Chi-Hsun Hsieh, Martin G. Schwacha, et al. "Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis." Journal of Applied Physiology 105, no. 2 (2008): 595–602. http://dx.doi.org/10.1152/japplphysiol.00012.2008.

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Although studies have shown that administration of testosterone receptor antagonist, flutamide, following trauma-hemorrhage, improves hepatic, cardiovascular, and immune functions, the precise cellular/molecular mechanisms responsible for producing these salutary effects remain largely unknown. To study this, male C3H/HeN mice were subjected to a midline laparotomy and hemorrhagic shock (35 ± 5 mmHg for ∼90 min), followed by resuscitation with Ringer lactate. Flutamide (25 mg/kg) or vehicle was administered subcutaneously at the onset of resuscitation, and animals were killed 2 h thereafter. H

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Imanishi, Masaki, Yuki Izawa-Ishizawa, Takumi Sakurada, et al. "Nitrosonifedipine, a Photodegradation Product of Nifedipine, Suppresses Pharmacologically Induced Aortic Aneurysm Formation." Pharmacology 102, no. 5-6 (2018): 287–99. http://dx.doi.org/10.1159/000492577.

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Background/Aims: We have reported that nitrosonifedipine (NO-NIF), a photodegradation product of nifedipine, has strong antioxidant and endothelial protective effects, and can suppress several cardiovascular diseases in animal models. The objective of the present study was to investigate the effects of NO-NIF on aortic aneurysm formation. Methods: The mice were infused with β-aminopropionitrile for 2 weeks and angiotensin II for 6 weeks to induce aortic aneurysm formation. The oxidative stress was measured by dihydroethidium staining and nitrotyrosine staining. The expressions of inflammation-

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Teng, Ru-Jeng, Tzong-Jin Wu, Adeleye J. Afolayan, and Girija G. Konduri. "Nitrotyrosine impairs mitochondrial function in fetal lamb pulmonary artery endothelial cells." American Journal of Physiology-Cell Physiology 310, no. 1 (2016): C80—C88. http://dx.doi.org/10.1152/ajpcell.00073.2015.

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Nitration of both protein-bound and free tyrosine by reactive nitrogen species results in the formation of nitrotyrosine (NT). We previously reported that free NT impairs microtubule polymerization and uncouples endothelial nitric oxide synthase (eNOS) function in pulmonary artery endothelial cells (PAEC). Because microtubules modulate mitochondrial function, we hypothesized that increased NT levels during inflammation and oxidative stress will lead to mitochondrial dysfunction in PAEC. PAEC isolated from fetal lambs were exposed to varying concentrations of free NT. At low concentrations (1–1

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Pepe, Giacomo, Shara Francesca Rapa, Emanuela Salviati, et al. "Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells." Antioxidants 9, no. 8 (2020): 699. http://dx.doi.org/10.3390/antiox9080699.

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Intestinal epithelial cells (IECs) play a pivotal role in maintaining intestinal homeostasis. Different noxious agents, among them also anticancer therapies, can impair intestinal epithelial integrity triggering inflammation and oxidative stress. A frequent complication of chemotherapy is gastrointestinal mucositis, strongly influencing the effectiveness of therapy, increasing healthcare costs, and impairing patients’ quality of life. Different strategies are used to treat gastrointestinal mucositis, including products from natural sources. Our study focused on the effect of pomegranate (Punic

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Fouda, Sherouk, Anwar Khan, Stanley M. H. Chan, et al. "Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress." Clinical Science 135, no. 17 (2021): 2103–19. http://dx.doi.org/10.1042/cs20210628.

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Abstract Consumption of diet rich in fat and cigarette smoking (CS) are independent risk factors of non-alcoholic steatohepatitis (NASH), and they often occur together in some populations. The present study investigated the mechanisms of high-fat diet (HFD) and CS, individually and in combination, on the pathogenesis of NASH in mice. C57BL/6 male mice were subjected to either a low-fat chow (CH) or HFD with or without mainstream CS-exposure (4 cigarettes/day, 5 days/ week for 14 weeks). HFD alone caused hepatosteatosis (2.5-fold increase in TG content) and a significant increase in 3-nitrotyri

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Toblli, Jorge Eduardo, Carlos Rivas, Gabriel Cao, et al. "Ferric Carboxymaltose-Mediated Attenuation of Doxorubicin-Induced Cardiotoxicity in an Iron Deficiency Rat Model." Chemotherapy Research and Practice 2014 (April 30, 2014): 1–9. http://dx.doi.org/10.1155/2014/570241.

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Since anthracycline-induced cardiotoxicity (AIC), a complication of anthracycline-based chemotherapies, is thought to involve iron, concerns exist about using iron for anaemia treatment in anthracycline-receiving cancer patients. This study evaluated how intravenous ferric carboxymaltose (FCM) modulates the influence of iron deficiency anaemia (IDA) and doxorubicin (3–5 mg per kg body weight [BW]) on oxidative/nitrosative stress, inflammation, and cardiorenal function in spontaneously hypertensive stroke-prone (SHR-SP) rats. FCM was given as repeated small or single total dose (15 mg iron per

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Cejka, Cestmir, Jan Kossl, Barbora Hermankova, et al. "The Healing of Oxidative Injuries with Trehalose in UVB-Irradiated Rabbit Corneas." Oxidative Medicine and Cellular Longevity 2019 (September 19, 2019): 1–10. http://dx.doi.org/10.1155/2019/1857086.

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Our previous research revealed that trehalose, a nonreducing disaccharide of glucose and an important stress responsive factor, proved to have anti-inflammatory, antiapoptotic, and particularly antioxidant properties in UVB-irradiated corneas. Trehalose reduced oxidative stress in corneas induced by UVB irradiation, by means of a decrease in the antioxidant/prooxidant imbalance in the corneal epithelium. In this study, we demonstrate that trehalose of 3% or 6% concentration in eye drops directly decreases oxidative stress in UVB-irradiated corneas, by removing the excessive amount of reactive

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Wang, Yonggang, Zhiguo Zhang, Wanqing Sun, et al. "Sulforaphane Attenuation of Type 2 Diabetes-Induced Aortic Damage Was Associated with the Upregulation of Nrf2 Expression and Function." Oxidative Medicine and Cellular Longevity 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/123963.

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Type 2 diabetes mellitus (T2DM) significantly increases risk for vascular complications. Diabetes-induced aorta pathological changes are predominantly attributed to oxidative stress. Nuclear factor E2-related factor-2 (Nrf2) is a transcription factor orchestrating antioxidant and cytoprotective responses to oxidative stress. Sulforaphane protects against oxidative damage by increasing Nrf2 expression and its downstream target genes. Here we explored the protective effect of sulforaphane on T2DM-induced aortic pathogenic changes in C57BL/6J mice which were fed with high-fat diet for 3 months, f

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Shalaby, Lamiaa, Menaka Thounaojam, Amany Tawfik, et al. "Role of Endothelial ADAM17 in Early Vascular Changes Associated with Diabetic Retinopathy." Journal of Clinical Medicine 9, no. 2 (2020): 400. http://dx.doi.org/10.3390/jcm9020400.

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ADAM17, a disintegrin and metalloproteinase 17, is a transmembrane metalloproteinase that regulates bioavailability of multiple membrane-bound proteins via ectodomain shedding. ADAM17 activity was shown to contribute to a number of vascular pathologies, but its role in the context of diabetic retinopathy (DR) is not determined. We found that expression and enzymatic activity of ADAM17 are upregulated in human diabetic postmortem retinas and a mouse model of streptozotocin-induced diabetes. To further investigate the contribution of ADAM17 to vascular alterations associated with DR, we used hum

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Tseng, Tsui-Hwa, Wea-Lung Lin, Che-Kai Chang, Ko-Chao Lee, Shui-Yi Tung, and Hsing-Chun Kuo. "Protective Effects of Morus Root Extract (MRE) Against Lipopolysaccharide-Activated RAW264.7 Cells and CCl4-Induced Mouse Hepatic Damage." Cellular Physiology and Biochemistry 51, no. 3 (2018): 1376–88. http://dx.doi.org/10.1159/000495555.

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Background/Aims: Inflammation is one of the main contributors to chronic diseases such as cancer. It is of great value to identify the potential activity of various medicinal plants for regulating or blocking uncontrolled chronic inflammation. We investigated whether the root extract of Morus australis possesses antiinflammatory and antioxidative stress potential and hepatic protective activity. Methods: The microwave-assisted extractionwere was used to prepare the ethanol extract from the dried root of Morus australis (MRE), including polyphenolic and flavonoid contents. Lipopolysaccharide (L

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Deng, Isaac, Frances Corrigan, Sanjay Garg, Xin-Fu Zhou, and Larisa Bobrovskaya. "Further Characterization of Intrastriatal Lipopolysaccharide Model of Parkinson’s Disease in C57BL/6 Mice." International Journal of Molecular Sciences 22, no. 14 (2021): 7380. http://dx.doi.org/10.3390/ijms22147380.

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Parkinson’s disease (PD) is the most common movement disorder, characterized by progressive degeneration of the nigrostriatal pathway, which consists of dopaminergic cell bodies in substantia nigra and their neuronal projections to the striatum. Moreover, PD is associated with an array of non-motor symptoms such as olfactory dysfunction, gastrointestinal dysfunction, impaired regulation of the sleep-wake cycle, anxiety, depression, and cognitive impairment. Inflammation and concomitant oxidative stress are crucial in the pathogenesis of PD. Thus, this study aimed to model PD via intrastriatal

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Sureda, Antoni, Juan M. Batle, Xavier Capó, et al. "Scuba diving induces nitric oxide synthesis and the expression of inflammatory and regulatory genes of the immune response in neutrophils." Physiological Genomics 46, no. 17 (2014): 647–54. http://dx.doi.org/10.1152/physiolgenomics.00028.2014.

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Objective: Scuba diving, characterized by hyperoxia and hyperbaria, could increase reactive oxygen species production which acts as signaling molecules to induce adaptation against oxidative stress. The aim was to study the effects of scuba diving immersion on neutrophil inflammatory response, the induction of oxidative damage, and the NO synthesis. Design: Nine male divers performed a dive at 50 m depth for a total time of 35 min. Blood samples were obtained at rest before the dive, after the dive, and 3 h after the diving session. Measurements: Markers of oxidative and nitrosative damage, ni

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La Rosa, Giovanni, Salvatore Cardali, Tiziana Genovese та ін. "Inhibition of the nuclear factor—κB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spinal cord trauma in rats". Journal of Neurosurgery: Spine 1, № 3 (2004): 311–21. http://dx.doi.org/10.3171/spi.2004.1.3.0311.

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Object. The nuclear factor—κB (NF-κB) is a transcription factor that plays a pivotal role in the induction of genes involved in physiological processes and in the response to inflammation. The authors of recent studies have demonstrated that NF-κB and oxidative stress contribute to secondary injury after impact-induced spinal cord injury (SCI) in the rat. Dithiocarbamates are antioxidants that are potent inhibitors of NF-κB. The authors postulated that pyrrolidine dithiocarbamate (PDTC) would attenuate NF-κB—related inflammatory and oxidative events that occur after SCI. Methods. Spinal cord i

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Dhiman, Monisha, Jose Guillermo Estrada-Franco, Jasmine M. Pando, et al. "Increased Myeloperoxidase Activity and Protein Nitration Are Indicators of Inflammation in Patients with Chagas' Disease." Clinical and Vaccine Immunology 16, no. 5 (2009): 660–66. http://dx.doi.org/10.1128/cvi.00019-09.

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ABSTRACT In this study, we investigated whether inflammatory responses contribute to oxidative/nitrosative stress in patients with Chagas' disease. We used three tests (enzyme-linked immunosorbent assay, immuno-flow cytometry, and STAT-PAK immunochromatography) to screen human serum samples (n = 1,481) originating from Chiapas, Mexico, for Trypanosoma cruzi-specific antibodies. We identified 121 subjects who were seropositive for T. cruzi-specific antibodies, a finding indicative of an 8.5% seroprevalence in the rural population from Chiapas. Seropositive and seronegative subjects were examine

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Ibarrola, Jaime, Vanessa Arrieta, Rafael Sádaba, et al. "Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage." Clinical Science 132, no. 13 (2018): 1471–85. http://dx.doi.org/10.1042/cs20171389.

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Galectin-3 (Gal-3) is increased in heart failure (HF) and promotes cardiac fibrosis and inflammation. We investigated whether Gal-3 modulates oxidative stress in human cardiac fibroblasts, in experimental animal models and in human aortic stenosis (AS). Using proteomics and immunodetection approaches, we have identified that Gal-3 down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. In parallel, Gal-3 increased peroxide, nitrotyrosine, malondialdehyde, and N-carboxymethyl-lysine levels and decreased total antioxidant capacity. Gal-3 decreased prohibitin-2 expression w

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Zhang, Hong-Xia, Shu-Juan Liu, Xiao-Lu Tang, et al. "H2S Attenuates LPS-Induced Acute Lung Injury by Reducing Oxidative/Nitrative Stress and Inflammation." Cellular Physiology and Biochemistry 40, no. 6 (2016): 1603–12. http://dx.doi.org/10.1159/000453210.

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Background: Hydrogen sulfide (H2S), known as the third endogenous gaseous transmitter, has received increasing attention because of its diverse effects, including angiogenesis, vascular relaxation and myocardial protection.We aimed to investigate the role of H2S in oxidative/nitrative stress and inflammation in acute lung injury (ALI) induced by endotoxemia. Methods: Male ICR mice were divided in six groups: (1) Control group; (2) GYY4137treatment group; (3) L-NAME treatment group; (4) lipopolysaccharide (LPS) treatment group; (5) LPS with GYY4137 treatment group; and (6) LPS with L-NAME treat

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Rapa, Shara Francesca, Francesco Prisco, Ada Popolo, et al. "Pro-Inflammatory Effects of Indoxyl Sulfate in Mice: Impairment of Intestinal Homeostasis and Immune Response." International Journal of Molecular Sciences 22, no. 3 (2021): 1135. http://dx.doi.org/10.3390/ijms22031135.

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The intestines are recognized as the main source of chronic inflammation in chronic kidney disease (CKD) and, among other cells, macrophages are involved in modulating this process as well as in the impaired immune response which also occurs in CKD patients. In this study, we evaluated the effect of Indoxyl Sulfate (IS), a protein bound uremic toxin poorly eliminated by hemodialysis, on inflammatory, oxidative stress and pro-apoptotic parameters, at the intestinal level in mice, on intestinal epithelial cells (IEC-6) and on primary murine peritoneal macrophages. C57BL/6J mice were treated with

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Jung, Ji Yun, Chul Won Lee, Sang Mi Park, et al. "Activation of AMPK byBuddleja officinalisMaxim. Flower Extract Contributes to Protecting Hepatocytes from Oxidative Stress." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/9253462.

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TheBuddleja officinalisMaxim. flower is used in traditional Chinese and Korean medicine to treat inflammation, vascular diseases, headache, and stroke, as well as enhance liver function. This research investigated the effects ofB. officinalisMaxim. flower extract (BFE) on hepatotoxicity. The cytoprotective effects and mechanism of BFE against severe mitochondrial dysfunction and H2O2production in hepatotoxicity induced by coadministration of arachidonic acid (AA) and iron were observed in the HepG2 cell line. In addition, we performed blood biochemical, histopathological, and histomorphometric

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Asghar, Mohammad, Gaurav Chugh, and Mustafa F. Lokhandwala. "Inflammation compromises renal dopamine D1 receptor function in rats." American Journal of Physiology-Renal Physiology 297, no. 6 (2009): F1543—F1549. http://dx.doi.org/10.1152/ajprenal.00366.2009.

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We tested the effects of inflammation on renal dopamine D1 receptor signaling cascade, a key pathway that maintains sodium homeostasis and blood pressure during increased salt intake. Inflammation was produced by administering lipopolysaccharide (LPS; 4 mg/kg ip) to rats provided without (normal salt) and with 1% NaCl in drinking water for 2 wk (high salt). Control rats had saline injection and received tap water. We found that LPS increased the levels of inflammatory cytokines, interleukin-6, and tumor necrosis factor-α in the rats given either normal- or high-salt intake. Also, these rats ha

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Quiroz, Yasmir, Atilio Ferrebuz, Freddy Romero, Nosratola D. Vaziri, and Bernardo Rodriguez-Iturbe. "Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction." American Journal of Physiology-Renal Physiology 294, no. 2 (2008): F336—F344. http://dx.doi.org/10.1152/ajprenal.00500.2007.

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The progressive deterioration of renal function and structure resulting from renal mass reduction are mediated by a variety of mechanisms, including oxidative stress and inflammation. Melatonin, the major product of the pineal gland, has potent_antioxidant and anti-inflammatory properties, and its production is impaired in chronic renal failure. We therefore investigated if melatonin treatment would modify the course of chronic renal failure in the remnant kidney model. We studied rats followed 12 wk after renal ablation untreated (Nx group, n = 7) and treated with melatonin administered in th

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Suliman, Hagir B., Lisa K. Ryan, Lisa Bishop, and Rodney J. Folz. "Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase." American Journal of Physiology-Lung Cellular and Molecular Physiology 280, no. 1 (2001): L69—L78. http://dx.doi.org/10.1152/ajplung.2001.280.1.l69.

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Reactive oxygen and nitrogen species such as superoxide and nitric oxide are released into the extracellular spaces by inflammatory and airway epithelial cells. These molecules may exacerbate lung injury after influenza virus pneumonia. We hypothesized that enhanced expression of extracellular superoxide dismutase (EC SOD) in mouse airways would attenuate the pathological effects of influenza pneumonia. We compared the pathogenic effects of a nonlethal primary infection with mouse-adapted Hong Kong influenza A/68 virus in transgenic (TG) EC SOD mice versus non-TG (wild-type) littermates. Compa

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Kocak, Zumrut, Meryem Temiz-Resitoglu, Demet Sinem Guden, et al. "Modulation of oxidative–nitrosative stress and inflammatory response by rapamycin in target and distant organs in rats exposed to hindlimb ischemia–reperfusion: the role of mammalian target of rapamycin." Canadian Journal of Physiology and Pharmacology 97, no. 12 (2019): 1193–203. http://dx.doi.org/10.1139/cjpp-2019-0394.

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Mammalian target of rapamycin (mTOR) has been recognized with potential immunomodulatory properties playing an important role in various physiopathological processes including ischemia–reperfusion (I/R) injury. I/R injury stimulate reactive oxygen and nitrogen species by activating nicotinamide adenine dinucleotide phosphate oxidase and inducible nitric oxide synthase, respectively. Controversial results have been obtained in different I/R models following localized I/R; however, the precise role of the mTOR signaling pathway remains undefined. The objective of the current study was to evaluat

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Pearson, James T., Hamish P. Thambyah, Mark T. Waddingham та ін. "β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat". Clinical Science 135, № 2 (2021): 327–46. http://dx.doi.org/10.1042/cs20201441.

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Abstract A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) have been shown to abolish inflammation and redox stress but only partially restore endothelial function in mesenteric vessels. We investigated whether sympatho-adrenal overactivation evokes coronary vascular dysfunction when a high salt intake is combined with insulin resistance in male Goto–Kakizaki (GK) and Wistar rats treate

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Zalewska, Anna, Dominika Ziembicka, Małgorzata Żendzian-Piotrowska, and Mateusz Maciejczyk. "The Impact of High-Fat Diet on Mitochondrial Function, Free Radical Production, and Nitrosative Stress in the Salivary Glands of Wistar Rats." Oxidative Medicine and Cellular Longevity 2019 (July 4, 2019): 1–15. http://dx.doi.org/10.1155/2019/2606120.

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Oxidative stress plays a crucial role in the salivary gland dysfunction in insulin resistance; however, the cause of increased free radical formation in these conditions is still unknown. Therefore, the aim of the study was to investigate the effect of high-fat diet (HFD) on the mitochondrial respiratory system, prooxidant enzymes, ROS production, and nitrosative/oxidative stress in the submandibular and parotid glands of rats. The experiment was performed on male Wistar rats divided into two groups (n=10): control and HFD. The 8-week feeding of HFD affects glucose metabolism observed as signi

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Strickland, Jaimie M., Doug Lyman, Lorraine M. Sordillo, Thomas H. Herdt, and John P. Buchweitz. "Effects of Super Nutritional Hepatic Copper Accumulation on Hepatocyte Health and Oxidative Stress in Dairy Cows." Veterinary Medicine International 2019 (May 5, 2019): 1–9. http://dx.doi.org/10.1155/2019/3642954.

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Concerns regarding excessive hepatic copper concentrations in dairy cows have increased. The objective of this study was to determine the association of hepatic copper concentrations with evidence of liver disease. Blood and liver samples were collected at the time of slaughter in cull dairy cows (n=100). Liver samples were analyzed for copper using inductively coupled plasma mass spectrometry and crude fat using liquid-liquid extraction and gravimetry. Serum samples were analyzed for glutamate dehydrogenase,γ-glutamyltransferase, sorbitol dehydrogenase, aspartate aminotransferase activities,

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Du, Xiaoping, Chul-Hee Choi, Kejian Chen, Weihua Cheng, Robert A. Floyd, and Richard D. Kopke. "Reduced Formation of Oxidative Stress Biomarkers and Migration of Mononuclear Phagocytes in the Cochleae of Chinchilla after Antioxidant Treatment in Acute Acoustic Trauma." International Journal of Otolaryngology 2011 (2011): 1–13. http://dx.doi.org/10.1155/2011/612690.

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Objective. Inhibition of inflammation and free radical formation in the cochlea may be involved in antioxidant treatment in acute acoustic trauma.Procedure. Chinchilla were exposed to 105 dB sound pressure level octave band noise for 6 hours. One group of chinchilla was treated with antioxidants after noise exposure. Auditory brainstem responses, outer hair cell counts, and immunohistochemical analyses of biomarkers in the cochlea were conducted.Results. The antioxidant treatment significantly reduced hearing threshold shifts, outer hair cell loss, numbers of CD45+cells, as well as 4-hydroxy-2

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