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Journal articles on the topic 'Oxo compound'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Gaber, Ahmed, Walaa F. Alsanie, Majid Alhomrani, Abdulhakeem S. Alamri, Ibrahim M. El-Deen, and Moamen S. Refat. "Synthesis of 1-[(Aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic Acid Derivatives and Their Breast Anticancer Activity." Crystals 11, no. 5 (2021): 571. http://dx.doi.org/10.3390/cryst11050571.

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This research aimed to produce new 1-[(aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic acid derivatives and check their anticancer effect against the breast cancer MCF-7 cell line. The 2-oxo-1,2-dihydroquinoline-3-carboxylic acid (4) compound was obtained by hydrolyzing ethyl 2-oxo-1,2-dihydroquinoline-3-carboxylate (2) with thiourea and anhydrous potassium carbonate ethanol, which was then treated with ethyl 3-substituted 2-cyanoacrylates (6) in the presence of triethylamine in diethyl formamide to give 1-[2-(ethoxy)carbonyl-2-cyano-1-arylvinyl]-2-oxo

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2

Hosny, Mona A., Wafaa A. Mokbe, and Emtithal A. El-Sawi. "Synthesis and Evaluation of Important Biologically Active Heterocyclic Compounds: Schiff Bases, Oxadiazole and Pyrazolyl Derivatives." JOURNAL OF ADVANCES IN CHEMISTRY 9, no. 2 (2013): 1892–99. http://dx.doi.org/10.24297/jac.v9i2.2341.

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In this work, we prepared an excellent yield of (2-oxo-2H-pyrano[3,2-h] quinolin-4-yl) acetic acid; compound (1) and from the reaction of it with hydrazine hydrate (100%) we obtain 2-(2-oxo-2H-pyrano [3,2-h] quinolin-4-yl) aceto hydrazide (2) which is the starting material for the synthesis of several series of new compounds: such as schiff’s bases (3a-e) and compound (4) in good yields, hydrazide derivatives like compound (5), derivatives of mercapto oxadiazole as compound (6) and derivatives of pyrazolyl as compound (7). All these compounds were found to possess high antimicrobial activity a

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3

Banfield, JE, GD Fallon, and BM Gatehouse. "Heterocyclic-Derivatives of Guanidine. VI. Formation and X-Ray Structure Determination of 2-Dimethylamino-7,8-diphenyl-4,6-dihydropyrrolo[1,2-a]pyrimidine-4,6-dione." Australian Journal of Chemistry 40, no. 5 (1987): 1003. http://dx.doi.org/10.1071/ch9871003.

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The structure N-(2-dimethylamino-4-oxo-7,8-diphenyl-4,6-dihydropyrrolo [l,2-a]pyrimidi n-6-yl-idene)acetamide (3) is proposed for a compound derived from the action of ketene on 2-(2-imino- 3,4-diphenyl-2H-pyrrol-5-yl)-1,1,3-trimethylguanidine (1; R1 = R2 = R3 = Me) on the basis of the crystal structure of its hydrolysis product, the oxo-compound 2-dimethylamino-7,8-diphenyl-4,6-dihydropyrrolo[l,2-a]pyrimidine-4,6-dione (4), the structure of which was determined by X-ray analysis. A lower homologue of (3), N-(2-methylamino-4-oxo-7,8-diphenyl-4,6-dihydro- pyrrolo[l,2-a]pyrimidin-6-ylidene)aceta

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4

Ibrahem, Raghad Abdalrazaq, and Shetha F. N. Al Zobady. "SYNTHESIS AND CHARACTERIZATION OF NEW HETEROCYCLIC DERIVATIVES FROM 7- HYDROXY -4- METHYL COUMARIN AND STUDY ANTIOXIDANT ACTIVITY FOR SOME SYNTHETIC COMPOUNDS." Iraqi Journal of Market Research and Consumer Protection 15, no. 1 (2023): 120–31. http://dx.doi.org/10.28936/jmracpc15.1.2023.(11).

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ABSTRACT 7-Hydroxy-4-methyl coumarin(H1) compound have been synthesized by resorcinol and ethyl acetoacetate reaction. 4-methyl-2-oxo-2H-chromen-7-yl 2-chloroacetate(H2) is highly reactive compounds. It has been used as intermediate in some reactions. It has been synthesized and reacted with hydrazine hydrate to produce4-methyl-2-oxo-2H-chromen-7-yl 2-hydrazinylacetate (H3).Schiff Bases Compound (H4) is synthesized by reacting the compound (H3) with P-hydroxy benzaldehyde, then reacted(H4) with sodium azide, mercaptoacetic acid, chloroacetyl chloride and anhydrides such as (3- nitro phathalic

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5

Nguyen, Cong T., Quang T. Nguyen, Phuc H. Dao, Thuan L. Nguyen, Phuong T. Nguyen, and Hung H. Nguyen. "Synthesis and Cytotoxic Activity against K562 and MCF7 Cell Lines of Some N-(5-Arylidene-4-oxo-2-thioxothiazolidin-3-yl)-2-((4-oxo-3-phenyl-3,4-dihydroquinazoline-2-yl)thio)acetamide Compounds." Journal of Chemistry 2019 (September 10, 2019): 1–8. http://dx.doi.org/10.1155/2019/1492316.

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Ethyl 2-((4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)thio)acetate (3) which was synthesized starting from anthranilic acid (1) via 2-thioxo-3-phenylquinazolin-4(3H)-one (2) reacted with hydrazine hydrate to afford 2-((4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)thio)acetohydrazide (4). Reaction of (4) with thiocarbonyl-bis-thioglycolic acid gave a new compound name N-(4-oxo-2-thioxothiazolidin-3-yl)-2-((4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)thio)acetamide (5). Knoevenagel condensation of (5) with appropriate aldehydes gave fourteen (Z)-N-(5-arylidene-4-oxo-2-thioxothiazolidin-3-yl)-2-((4-oxo-

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6

Madugula, Aravinda Kumar, K. Jagadeesh, D. B. N. Suresh Varma, et al. "A New Series of Indole and Azaindole Derivatives with Oxo-dihydropyridines: Synthesis, Characterization and Cytotoxicity Studies against Breast Malignant Cell Lines." Asian Journal of Chemistry 36, no. 3 (2024): 669–76. http://dx.doi.org/10.14233/ajchem.2024.30317.

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In this investigation, a novel series of indole and azaindole comprising oxo-dihydropyridine derivatives was synthesized. From their spectral (1H NMR and FTIR) as well as elemental (MS) investigations, the structures of all the synthesized 12 oxo-dihydropyridine derivatives were determined. Cytotoxicity of synthesized twelve compound was evaluated against MDA-MB-231 malignant breast cells had been assessed. Compound 1,6-diamino-4-(1H-indol-3-yl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile showed more percent of inhibition of growth and four more derivatives showed moderate percent of inhibiti

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7

Zheoat, Ahmed M., Alexander I. Gray, John O. Igoli, Alan R. Kennedy, and Valerie A. Ferro. "Crystal structures of hibiscus acid and hibiscus acid dimethyl ester isolated fromHibiscus sabdariffa(Malvaceae)." Acta Crystallographica Section E Crystallographic Communications 73, no. 9 (2017): 1368–71. http://dx.doi.org/10.1107/s2056989017011902.

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The biologically active title compounds have been isolated fromHibiscus sabdariffaplants, hibiscus acid as a dimethyl sulfoxide monosolvate [systematic name: (2S,3R)-3-hydroxy-5-oxo-2,3,4,5-tetrahydrofuran-2,3-dicarboxylic acid dimethyl sulfoxide monosolvate], C6H6O7·C2H6OS, (I), and hibiscus acid dimethyl ester [systematic name: dimethyl (2S,3R)-3-hydroxy-5-oxo-2,3,4,5-tetrahydrofuran-2,3-dicarboxylate], C8H10O7, (II). Compound (I) forms a layered structure with alternating layers of lactone and solvent molecules, that include a two-dimensional hydrogen-bonding construct. Compound (II) has tw

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8

Karrar A. Hchim and Mohammed Kamel. "Synthesis, Characterization and Antimicrobial Evaluation of New Schiff Bases Containing 4-Hydroxycoumarin." Iraqi Journal of Pharmaceutical Sciences 34, no. 1 (2025): 185–91. https://doi.org/10.31351/vol34iss1pp185-191.

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The goal of This study is to make new coumarin derivatives, describe them in detail from a chemical standpoint, and test their antimicrobial properties. New Schiff base of compound (III) 2-[(2-oxo-2H-chromen-4-yl)oxy]acetohydrazide have been successfully prepared by the reaction of proper aryl/hetero aromatic aldehydes with compound (III) under conventional Conditions. The compound 4-hydroxycoumarin (I) undergoes a reaction with ethylbromoacetate in the presence of potassium carbonate and dry acetone, resulting in the formation of comound )II( ethyl2-((2-oxo-2h-chromen-4-yl)oxy)acetate , which

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9

Alagarsamy, Veerachamy, Viswas Raja Solomon, Mohaideen Thasthagir Sulthana, Meduri Satyasai Vijay, and Bandi Narendhar. "Design and synthesis of quinazolinyl acetamides for their analgesic and anti-inflammatory activities." Zeitschrift für Naturforschung B 70, no. 8 (2015): 597–604. http://dx.doi.org/10.1515/znb-2015-0035.

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AbstractA variety of novel 2-(substituted)-N-(4-oxo-2-phenylquinazolin-3(3H)-yl)acetamides were synthesized by the reaction of 2-chloro-N-(4-oxo-2-phenylquinazolin-3(3H)-yl)acetamide with various amines. The starting material, 2-chloro-N-(4-oxo-2-phenylquinazolin-3(3H)-yl)acetamide, was synthesized from anthranilic acid by the multistep process. The title compounds were investigated for analgesic, anti-inflammatory, and ulcerogenic index activities. Among those, the compound 2-(ethylamino)-N-(4-oxo-2-phenylquinazolin-3(3H)-yl)acetamide (V9) showed most potent analgesic and anti-inflammatory ac

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10

Ibrahim, A. A., O. M. Yahya, and M. A. Ibrahim. "Theoretical Prediction of Possible Drug Treatment of COVID-19 using Coumarins Containing Chloroquine Moeity." Asian Journal of Chemistry 32, no. 12 (2020): 3120–26. http://dx.doi.org/10.14233/ajchem.2020.22914.

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Chloroquine was theoretically reacted with the coumarin compound. Two compounds viz. [N-(7-chloroquinolin-4-yl)-N-(5-(diethylamino)-pentan-2-yl)-4-methyl-2-oxo-2H-chromene-7- sulfonamide] (3) and [N-(7-chloroquinolin-4-yl)-N-(5-(diethylamino)pentan-2-yl)-4-methyl-2-oxo- 2H-chromene-6-sulfonamide] (4) were suggested. The results showed that compound 4 may influence the COVID-19 treatment. The physico-chemical parameters were determined through theoretical calculations by using Hartree-Fock at different basis sets (6-31G), (STO/3G) and the semi-empirical (AM1) method. The calculations demonstrat

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11

Rádl, Stanislav, and Viktor Zikán. "Synthesis and biological activity of some basic-substituted 4,9-dihydro-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinolines." Collection of Czechoslovak Chemical Communications 53, no. 8 (1988): 1812–19. http://dx.doi.org/10.1135/cccc19881812.

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Compounds Ia, Ib were obtained by an alkylation of 4,9-dihydro-6-hydroxy-1,3,9-trimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (VIIb) with the respective dialkylaminoalkyl chloride. The same alkylation of 4,9-dihydro-6-hydroxy-2,3,9-trimethyl-4-oxo-2H-pyrazolo[3,4-b]quinoline (VIIIb) yielded compounds IIa and IIb. Similar alkylation of 4,9-dihydro-6-hydroxy-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (IXa) and its 6-methoxy derivative (IXb) afforded IIIa-IIId. Compound IV was prepared from 4-chloro-3-methyl-1H-pyrazolo[3,4-b]quinoline (Xa) via its 1-(3-dimethylaminopropyl)derivative (Xb). Compo

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12

Sharma, Shalabh, and Kuldeep Kumar Saxena. "Synthesis and Antibacterial Activity of Azetidinonyl Norfloxacin Congeners." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 3 (2015): 2967–71. http://dx.doi.org/10.37285/ijpsn.2015.8.3.11.

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Some novel Schiff bases and azetidinone congeners of norfloxacin have been synthesized and screened for antibacterial activity. The structures of compounds 1-ethyl-6-fluoro-7-piperazinyl-4-oxo-3-(substitutedarylidinylcarboxy- hydrazido)quinolines (2-6) and 1-ethyl-6-fluoro-7-pipera-zinyl-4-oxo-3-(3′-choloro-2′-oxo-4′-substitutedaryl-3′-aze-tidinyl)-aminocarboxy quinolines (7-11) were established by spectral and elemental analysis. The compounds 2-11 were evaluated in vitro against various strains of bacteria: E. coli ATCC 25922, B. subtilis ATCC 1633 and S. aureus ATCC 25923 to determine their

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13

Ahmed, Amer Mahmoud. "Synthesis and Characterization of New Coumarin Derivatives." BASRA JOURNAL OF SCIENCE 40, no. 1 (2022): 43–65. http://dx.doi.org/10.29072/basjs.20220103.

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New Schiff base compounds 3-acetyl-2-oxo-2H-chromen-7-yl-4(alkyloxy) benzoate thiosem icarbazide have been synthesized from the reaction between thiosemicarbazide and substituted coumarin. Target compound were characterized by FT-IR and NMR techniques heterogeneous coumarin compound. The result confirms the structure as suggested

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14

Adachi, Kyoko, Tokuro Iwabuchi, Hiroshi Sano, and Shigeaki Harayama. "Structure of the Ring Cleavage Product of 1-Hydroxy-2-Naphthoate, an Intermediate of the Phenanthrene-Degradative Pathway ofNocardioides sp. Strain KP7." Journal of Bacteriology 181, no. 3 (1999): 757–63. http://dx.doi.org/10.1128/jb.181.3.757-763.1999.

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ABSTRACT 1-Hydroxy-2-naphthoate (compound I) is a metabolite of the phenanthrene-degradative pathway in Nocardioides sp. strain KP7. This singly hydroxylated aromatic compound is cleaved by 1-hydroxy-2-naphthoate dioxygenase. In this study, the structure of the ring cleavage product generated by the action of homogeneous 1-hydroxy-2-naphthoate dioxygenase was determined upon separation by high-performance liquid chromatography at pH 2.5 by using nuclear magnetic resonance (NMR) and mass spectroscopic techniques. The ring cleavage product at this pH existed in equilibrium between two forms, 2-o

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15

Alam, Mahboob, Youngwon Kim, and Soonheum Park. "Synthesis, characterization (IR, 1H, 13C & 31P NMR), fungicidal, herbicidal and molecular docking evaluation of steroid phosphorus compounds." Open Chemistry 17, no. 1 (2019): 621–28. http://dx.doi.org/10.1515/chem-2019-0069.

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AbstractPhosphorus containing steroidal derivatives such as 3β-oxo-[diazaphosphalidine-2’-one] stigmast-5-ene and 3β-oxo-[diazaphosphalidine-2’-one] stigmast-5,22-diene were designed, synthesized and characterized using spectroscopic techniques (IR, 1H, 13C & 31P NMR, HRMS) and elemental analysis. The fungicidal and herbicidal studies of the compounds were performed and the experimental outcomes showed that compound 4 showed a good fungicidal activity against mycelium growth of fungi, while in the case of herbicidal activity, both compounds show a moderate activity compared to the commerci

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16

Al-Abboodi1, Doaa Hashim, and Naeemah Al-lami. "NEW METHDOLOGY OF SYNTHESIS PYRAZOLO- THIAZOLO DERIVATIVES WITH STUDY ANTIMICROBAL ACTIVITIES." iraqi journal of market research and consumer protection 16, no. 1 (2024): 1–12. http://dx.doi.org/10.28936/jmracpc16.1.2024.(1).

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In this contribution, new derivatives of thiosemicarbazon, cyclic thiazolidinone, yilidine thiazolidinone, and parazolo-thiazole were synthesized, starting from the reaction of 2 -aminobenzothiazole with p-bromo phenacyl bromide to give the first step of 2(4-bromo phenyl) imidazole (2,1 -b) benzo thiazole (1). Compound (1) then was subjected under Viels Myer Haack to yield 3-carbaldehyde linking with imidazo-benzothiazol (2). Compound (2) condensed with thiosemicarbazide togivenewsynthesis of thiosemicarbazon derivative (3). Compound 4-Oxo-1,3-thiazolidine (4) was constituted from reacting com

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17

Collins, Daniel P., Issa S. Isaac, Eric D. Coulter, Paul W. Hager, David P. Ballou, and John H. Dawson. "Reaction of ferric Caldariomyces fumago chloroperoxidase with meta-chloroperoxybenzoic acid: sequential formation of compound I, compound II and regeneration of the ferric state using one reactant." Journal of Porphyrins and Phthalocyanines 17, no. 01n02 (2013): 63–72. http://dx.doi.org/10.1142/s1088424612501234.

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The mechanism of the reaction between ferric Caldariomyces fumago chloroperoxidase (CCPO) and meta-chloroperoxybenzoic acid (mCPBA) has been examined. It has previously been established that an Fe(IV) -oxo porphyrin radical species known as Compound I (Cpd I) is formed by two-electron oxidation of the native ferric enzyme by a variety of oxidants including organic peracids and hydroperoxides. Cpd I can return to the ferric state either by direct oxygen insertion into an organic substrate (e.g. a P450 oxygenase-like reaction), or by two consecutive one-electron additions, the first resulting in

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18

Danish, Isravel A., and Karnam J. R. Prasad. "An Elegant Synthetic Route to 3-Cyano-5,6-dihydro-2-ethoxy-4-phenyl-pyrido[2,3-a]carbazoles." Zeitschrift für Naturforschung B 59, no. 1 (2004): 106–8. http://dx.doi.org/10.1515/znb-2004-0115.

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Abstract 2-Benzylidene-1-oxo-1,2,3,4-tetrahydrocarbazoles (1a - e) obtained from the corresponding 1- oxo-1,2,3,4-tetrahydrocarbazoles on reaction with malononitrile in dry benzene with sodium hydride afforded 3-cyano-5,6-dihydro-2-ethoxy-4-phenyl-pyrido[2,3-a]carbazoles (2a - e) in good yields. A plausible mechanism for the formation of the title compound has been proposed and all the compounds were characterised by IR, NMR, mass spectral methods and elemental analysis.

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19

Djurendić, Evgenija A., Marina P. Zaviš, Marija N. Sakač, Vesna V. Kojić, Gordana M. Bogdanović, and Katarina M. Penov Gaši. "Synthesis and Biological Evaluation of Some A,D-Ring Modified 16,17-Secoandrostane Derivatives." Collection of Czechoslovak Chemical Communications 73, no. 5 (2008): 627–36. http://dx.doi.org/10.1135/cccc20080627.

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Starting from 3β-hydroxy-17-oxo-16,17-secoandrost-5-ene-16-nitrile (1), the new 16,17-secoandrostane derivatives 2-11 were synthesized. Protection of the 17-oxo function of compound 1 with ethylene glycol yielded compounds 2 and 3. The Oppenauer oxidation of 2 or oxidation with H2O2 in alkaline conditions gave the respective compounds 4 and 10. Epoxidation of compound 4 yielded a mixture of 4α,5α- and 4β,5β-epoxides 5 and 6 and a mixture of 4α,5α- and 4β,5β-epoxy-carboxamides 7 and 8. Opening of the oxirane ring of a mixture of compounds 5 and 6 with formic acid afforded the 4-hydroxy derivati

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20

Steiger, Scott A., Anthony J. Monacelli, Chun Li, Janet L. Hunting, and Nicholas R. Natale. "The effect of bromine scanning around the phenyl group of 4-phenylquinolone derivatives." Acta Crystallographica Section C Structural Chemistry 70, no. 8 (2014): 790–95. http://dx.doi.org/10.1107/s2053229614015617.

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Three quinolone compounds were synthesized and crystallized in an effort to study the structure–activity relationship of these calcium-channel antagonists. In all three quinolones,viz.ethyl 4-(4-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, (I), ethyl 4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, (II), and ethyl 4-(2-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, (III), all C21H24BrNO3, common structural features such as a flat boat conformation of the 1,4-dihydropyridine (1,4-DHP) ring

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21

Steiger, Scott A., Chun Li, Christina Gates, and Nicholas R. Natale. "Synthesis and crystal structures of a bis(3-hydroxy-cyclohex-2-en-1-one) and two hexahydroquinoline derivatives." Acta Crystallographica Section E Crystallographic Communications 76, no. 2 (2020): 125–31. http://dx.doi.org/10.1107/s2056989019017018.

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The title compound I, 2,2′-[(2-nitrophenyl)methylene]bis(3-hydroxy-5,5-dimethylcyclohex-2-enone), C23H27NO6, features a 1,3-ketone–enol conformation which is stabilized by two intramolecular hydrogen bonds. The most prominent intermolecular interactions in compound I are C—H...O hydrogen bonds, which link molecules into a two-dimensional network parallel to the (001) plane and a chain perpendicular to (1\overline{1}1). Both title compounds II, ethyl 4-(4-hydroxy-3,5-dimethoxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C23H29NO6, and III, ethyl 4-(anthracen-9-yl)

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22

Sharulatha, Venugopal, Anbazhagan Abinaya, Rajeswari M., and Sundaram Sivakamasundari. "Synthesis, characterization and molecular docking of N-aryl amides of pyrido[1,2-a]pyrimidin2-ones as potential antibacterial agents." Journal of Indian Chemical Society Vol. 97, No. 9b, Sept 2020 (2020): 1584–89. https://doi.org/10.5281/zenodo.5665014.

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Department of Chemistry, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore-641 043, Tamil Nadu, India <em>E-mail:</em> abinayachemist@gmail.com <em>Manuscript received online 26 July 2020, accepted 30 August 2020</em> Nitrogen-containing heterocyclic compounds play the most key role in the discovery of new drugs. Among all, pyrimidine possesses a wide spectrum because of its positive pharmacological and biological properties. Some novel amides of pyrido[1,2- <em>a</em>]pyrimidine-2-one acetic acids were synthesized, and the structure of the products was

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23

Krishnan, Suresh Kumar, Swastika Ganguly, Ravichandran Veerasamy, and Pandy Vijayapandi. "Synthesis, Antiviral and Antimicrobial Activities of Quinazoline Urea Analogues." International Journal of Drug Design and Discovery 4, no. 4 (2025): 1215–30. https://doi.org/10.37285/ijddd.4.4.6.

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A new series of quinazoline urea were synthesized and evaluated for antiviral and antimicrobial activity. Compound 4k [1-(2-chlorophenyl)-3-(4-oxo-2-phenylquinazolin-3(4H)-yl) urea] inhibited the replication of influenza A H1N1, influenza A H3N2 and influenza B at EC50 of 0.025 µM. Compound 4e [1-(2-methyl-4-oxoquinazolin-3(4H)-yl)-3-(4-nitrophenyl) urea] was found to potentially inhibits replication of Coxsackie virus B4, Vesiculat stomatitis virus and Respiratory syncytial virus at EC50 of 0.029 µM. The compounds were also tested for their in vitro antibacterial and antifungal activity again

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Gaffke, Alexander M., Sharlene E. Sing, Jocelyn G. Millar, et al. "An Herbivore-Induced Plant Volatile From Saltcedar (Tamarix spp.) Is Repellent to Diorhabda carinulata (Coleoptera: Chrysomelidae)." Environmental Entomology 49, no. 5 (2020): 1063–70. http://dx.doi.org/10.1093/ee/nvaa079.

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Abstract The leaf beetle Diorhabda carinulata Desbrochers (Coleoptera: Chrysomelidae) was introduced into the United States in 1999 for classical biological control of the exotic woody invader saltcedar (Tamarix spp. L. [Caryophyllales: Tamaricaceae]). The recent southern expansion of the range of D. carinulata in the United States has precipitated conflict between proponents of biological control of Tamarix and those with concerns over habitat conservation for avian species. Several semiochemicals that mediate aggregations by this species have been reported, but no repellent compounds have be

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Almutairi, Maha S., Areej N. Al Suwayyid, Amal Aldarwesh, Omaima M. Aboulwafa, and Mohamed I. Attia. "Antiestrogenic Activity and Possible Mode of Action of Certain New Nonsteroidal Coumarin-4-acetamides." Molecules 25, no. 7 (2020): 1553. http://dx.doi.org/10.3390/molecules25071553.

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The preparation of certain 2-(2-oxo-2H-chromen-4-yl)-N-substituted acetamides IIIa–h was planned as a step in the development of new modified nonsteroidal antiestrogens. The purity of target compounds IIIa–h was checked by thin-layer chromatography (TLC), and their structures were confirmed using various spectroscopic tools including IR, 1H-NMR, 13C-NMR, and MS spectroscopy. Viability tests were applied using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay to evaluate the cytotoxic effect of the synthesized compounds against two breast cancer cell lines, MCF-7 and MDA

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Hakimah, Wafiq Kholifatul, Ahmad Fauzi, Muhammad Reza Ramadhan, and Fariha Mufidah Maulina. "SYNTHESIS OF DIHYDROPYRIMIDINONE DERIVATIVES AND CYTOTOXIC ACTIVITY TEST AGAINST T47D CANCER CELLS." Medical Sains : Jurnal Ilmiah Kefarmasian 10, no. 2 (2025): 145–52. https://doi.org/10.37874/ms.v10i2.1693.

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Dihydropyrimidinone (DHPM) derivatives are heterocyclic compounds known for a variety of biological activities including anticancer properties. The Mitsunobu reaction was used in this study to synthesize a new DHPM derivative, ethyl 4-(4-isopropoxy-3,5-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (compound B2), and assess its cytotoxic activity against T47D breast cancer cells. Compound B2 was synthesized from ethyl 4-(4-hydroxy-3,5-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (compound M1) using multicomponent reactions (MCR) and the M

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27

Gomes, Ligia R., John Nicolson Low, James L. Wardell, et al. "Crystal structures and Hirshfeld surface analyses of (E)-N′-benzylidene-2-oxo-2H-chromene-3-carbohydrazide and the disordered hemi-DMSO solvate of (E)-2-oxo-N′-(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide: lattice energy and intermolecular interaction energy calculations for the former." Acta Crystallographica Section E Crystallographic Communications 75, no. 10 (2019): 1403–10. http://dx.doi.org/10.1107/s2056989019012015.

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The crystal structures of the disordered hemi-DMSO solvate of (E)-2-oxo-N′-(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide, C20H18N2O6·0.5C2H6OS, and (E)-N′-benzylidene-2-oxo-2H-chromene-3-carbohydrazide, C17H12N2O3 (4: R = C6H5), are discussed. The non-hydrogen atoms in compound [4: R = (3,4,5-MeO)3C6H2)] exhibit a distinct curvature, while those in compound, (4: R = C6H5), are essential coplanar. In (4: R = C6H5), C—H...O and π–π intramolecular interactions combine to form a three-dimensional array. A three-dimensional array is also found for the hemi-DMSO solvate of [4: R = (3,4,

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Nuber, B., W. Schatz та M. L. Ziegler. "Darstellung und Charakterisierung der μ3-Oxo-Cluster [Cp3Mo3(CO)4µ-Cl)(µ3-O)] und [Cp3Mo3(µ-CO)3(CO)3(µ3-O)]+ / Synthesis and Characterization of the µ3-Oxo Clusters [Cp3Mo3(CO)4μ-Cl)(μ3-O)] and [Cp3Mo3(μ-CO)3(CO)3(μ3-O)]+". Zeitschrift für Naturforschung B 45, № 4 (1990): 508–14. http://dx.doi.org/10.1515/znb-1990-0416.

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[CpMo(CO)3]2 (1) (Cp = cyclopentadienyl) reacts with InCl3 in diglyme to yield the oxo-cluster [Cp3Mo3(CO)4(μ-Cl)(μ3-O)] (2) and the cationic oxo-cluster [Cp3Mo3(μ-CO)3(CO)3(μ3-O)]+ as the salt [Cp3Mo3(μ-CO)3(CO)3(μ3-O)][CpMo(CO)3InCl3] (3). The compounds were characterized by elemental analysis, spectroscopic data and X-ray structure analysis. Compound 2 crystallizes in the orthorhombic space group P212121 with a = 1006.0(3), b = 1244.6(4) and c = 1600.8(5) pm, V = 2004.3 x 106 pm3, Z = 4. Compound 3 crystallizes in the monoclinic space group P 21/m with a = 874.4(8), b = 1407(1) and c = 1500

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29

Gangadhar, S. Bhopalkar. "Synthesis, Characterization and Antibacterial Activity of 3-amino-6,9-dimethyl-4-oxo-Pyrazolo[3,4-e] Pyrimido[2,3-b][1,3] Benzothiazole." Chemistry Research Journal 7, no. 3 (2022): 121–24. https://doi.org/10.5281/zenodo.11402591.

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<strong>Abstract </strong> Novel fused heterocyclic compound 3-amino-6,9-dimethyl-4-oxo pyrazolo[3,4-<em>e</em>]-pyrimido[2,1-<em>b</em>][1,3] benzothiazole (4) was prepared by the reaction of 3-cyano-6, 9-dimethyl- 4-oxo 2-methylthio-4H-pyrimido[2,1-<em>b</em>][1,3] benzothiazole (3) with hydrazine hydrate in presence of anhydrous K<sub>2</sub>CO<sub>3</sub> in DMF. The compound (3) was synthesized by the reaction of 2-amino- 4,7- dimethyl [1, 3] benzothiazole (1) with Ethyl -2-cyano-3,3’-bis-methylthio acrylate (2). All the synthesised compounds were characterised by spectral analysis

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30

Khan, Azhar U., Mahboob Alam, Soonheum Park, Poonam Dwivedi, Sunil K. Sharma, and Sapna Jain. "Synthesis, Antibacterial Activity and Molecular Docking of Phospholidinones in Stigmastane Series." Current Computer-Aided Drug Design 15, no. 3 (2019): 259–64. http://dx.doi.org/10.2174/1573409914666181029122448.

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<P>Introduction: Steroid compounds are widely distributed in nature throughout scientific history. Living organisms such as animals and vegetables have steroids that show a significant effect on their vital activities. Sterols are key components of all eukaryotic cell membranes. Methods: Steroidal compounds; 3β-oxo-[1’,3’,2’-oxathiaphos-phalidine-2’-one] stigmast-5-ene and 3β- oxo[1`,3`,2`-dioxaphosphalidine-2`-one]-stigmast-5-ene were successfully prepared using easily accessible 3β-hydroxy stigmast-5-ene with phosphorous oxychloride (POCl3), 2- mercaptoethanol/ethylene glycol and triet

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31

Abd Elhady, Hebe, Hossa AL-SHAREEF, Khadeega Takroni, and Wedad Alharbi. "One-Pot Synthesis of New Bipyridine and Yerpyridine Derivatives: Anti-proliferative Evaluation, DNA Flow Cytometry Analysis, and Molecular Docking Study." Acta Poloniae Pharmaceutica - Drug Research 81, no. 3 (2024): 423–37. http://dx.doi.org/10.32383/appdr/191341.

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Some new bipyridine derivatives were synthesized using 2-oxo-4-(pyridin-3-yl)-6-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile 1a. While terpyridine derivatives were synthesized using 2-oxo-4-(pyridin-3-yl)-6-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile 1b as starting material. Alkylation of compounds 1a, b gave the alkyl derivatives 2a, b which converted into aceto hydrazides 3a,b. Treating the aceto hydrazides with ethyl cyanoacetate afforded 2'-(2-(3,5-dioxopyrazolidin-1-yl)-2-oxoethoxy)-6'-(thiophen-2-yl)-3,4'-bipyridine-3'-carbonitrile 4a and 6'-[2-(3,5-dioxopyrazolidin-1-yl)-2-o

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32

Zhu, Wu Fu, Yuan Biao Tu, Shan Xu, et al. "Rapid Synthesis of 4-oxo-4H-chromene-3-carboxylic Acid." Advanced Materials Research 1081 (December 2014): 16–19. http://dx.doi.org/10.4028/www.scientific.net/amr.1081.16.

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4-Oxo-4H-chromene-3-carboxylic acid (8) is an important intermediate in many biologically active compounds. In this work, a rapid synthetic method for compound 8 was established. The compound 8 was synthesized from the commercially available 1-(2-hydroxyphenyl) ethanone 9 through two steps including vilsmeier reaction and oxidation by Jones reagent. The structure was confirmed by1HNMR and13CNMR spectrum. Furthermore, the synthetic method was optimized.

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Krick, Anja, Stefan Kehraus, Leo Eberl, et al. "A Marine Mesorhizobium sp. Produces Structurally Novel Long-Chain N-Acyl-l-Homoserine Lactones." Applied and Environmental Microbiology 73, no. 11 (2007): 3587–94. http://dx.doi.org/10.1128/aem.02344-06.

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ABSTRACT Our study focused on a Mesorhizobium sp. that is phylogenetically affiliated by 16S rRNA gene sequence to other marine and saline bacteria of this genus. Liquid chromatography-mass spectrometry investigations of the extract obtained from solid-phase extraction of cultures of this bacterium indicated the presence of several N-acyl homoserine lactones (AHLs), with chain lengths of C10 to C16. Chromatographic separation of the active bacterial extract yielded extraordinarily large amounts of two unprecedented acylated homoserine lactones, 5-cis-3-oxo-C12-homoserine lactone (5-cis-3-oxo-C

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34

Ivanova, Yordanka B., Filip E. Svetoslavov, and Ognyan I. Petrov. "(E)-5-(3-Oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzo[d]oxazol-2(3H)-one." Molbank 2024, no. 3 (2024): M1866. http://dx.doi.org/10.3390/m1866.

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The title compound, (E)-5-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzo[d]oxazol-2(3H)-one, was synthesized by the acid- and base-catalyzed aldol condensation of 2-oxo-2,3-dihydrobenzo[d]oxazole-5-carbaldehyde and 3,4,5-trimethoxyacetophenone. The structure of the target compound was confirmed using 1H NMR, 13C NMR, HRMS, and elemental analysis.

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35

Neslihan, Demirbas. "Microwave Irradiated and Conventional Synthesis, Antibacterial Activity Evaluation Studies of Tryptamine-Azole-Fluoroquinolone Conjugates." Archive of Biomedical Science and Engineering 4, no. 1 (2018): 010–20. https://doi.org/10.17352/abse.000009.

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Tryptamine was converted to the corresponding 1,2,4-triazole, 1,3,4-oxadiazole, 5-oxo-1,3-thia(oxa)zolidine and 5-(4-chlorophenyl)-1,3-thia(oxa)zole derivatives via several steps. 1,3,4-oxadiazole and 1,2,4-triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-components procedure. Conventional and microwave-assisted methods were applied for all syntheses. All the newly synthesized compounds were screened for their antibacterial and most of them were found to have good–moderate antibacterial activity.

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36

Nancy, Sakshi Chaudhary, and Archana. "SYNTHESIS OF SOME NEWER THIAZOLIDINONYL QUINAZOLINONES AND AZETIDINONYL QUINAZOLINONES AS POTENT ANTI-INFLAMMATORY AGENTS." Indian Drugs 59, no. 08 (2022): 21–30. http://dx.doi.org/10.53879/id.59.08.13098.

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3-Substitutedphenyl-2-bromomethyl-6-substituted quinazolin-4(3H)-ones (7-10) were treated with hydrazine hydrate to give 3-substitutedphenyl-2-hydrazinomethyl-6-substituted quinazolin-4(3H)-ones (11-14). Compounds 11-14 were condensed with various aldehydes to afford 2-substitutedbenzylidene hydrazinomethyl-3-substitutedphenyl-6-substituted quinazolin-4(3H)-ones (15-22). Cycloaddition of compounds 15-22 with thioglycolic acid and triethylamine / chloroacetyl chloride yielded 2-[(4’-oxo-2’ -substitutedphenyl-thiazolidin-3’-yl)-aminomethyl]-3-substitutedphenyl-6-substituted quinazolin-4(3H)- one

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37

Bhagi-Damodaran, Ambika, and Yi Lu. "Compound Q is finally deciphered." Inorganic Chemistry Frontiers 2, no. 9 (2015): 824–26. http://dx.doi.org/10.1039/c5qi00117j.

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38

Tripathi, Rahul R., and Ratnamala P. Sonawane. "An Extraction of the Isatin from the Couroupita guianesis (Cannon Ball Tree) and a Novel Synthesis of the N,N'-(2-oxo-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazole]-3',5'-diyl]diacetamidefrom the Isatin." International Letters of Chemistry, Physics and Astronomy 15 (September 2013): 119–25. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.15.119.

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Isatins are synthetically versatile substrates, where they can be used for the synthesis of a large variety of Isatins and heterocyclic compounds. In this, the isatin were extracted from the floral material of Couroupita guianesis commonly known as an Cannon ball tree. After that, a novel heterocyclic spiro derivative having an IUPAC name N,N’-(2-oxo-3’H-spiro[indoline-3,2’-[1,3,4] thiadiazole]-3’5’-diyl)diacetamide were synthesized , which may be used as raw material for drug synthesis. A spiro compound N,N’-(2-oxo-3’H-spiro[indoline-3,2’-[1,3,4] thiadiazole]-3’5’-diyl)diacetamide were synthe

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39

Tripathi, Rahul R., and Ratnamala P. Sonawane. "An Extraction of the Isatin from the <i>Couroupita guianesis</i> (Cannon Ball Tree) and a Novel Synthesis of the N,N'-(2-oxo-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazole]-3',5'-diyl]diacetamidefrom the Isatin." International Letters of Chemistry, Physics and Astronomy 15 (June 29, 2013): 119–25. http://dx.doi.org/10.56431/p-h7k957.

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Isatins are synthetically versatile substrates, where they can be used for the synthesis of a large variety of Isatins and heterocyclic compounds. In this, the isatin were extracted from the floral material of Couroupita guianesis commonly known as an Cannon ball tree. After that, a novel heterocyclic spiro derivative having an IUPAC name N,N’-(2-oxo-3’H-spiro[indoline-3,2’-[1,3,4] thiadiazole]-3’5’-diyl)diacetamide were synthesized , which may be used as raw material for drug synthesis. A spiro compound N,N’-(2-oxo-3’H-spiro[indoline-3,2’-[1,3,4] thiadiazole]-3’5’-diyl)diacetamide were synthe

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40

Medishetti, Nagaraju, Ashok Kale, Jagadeesh Nanubolu, and Krishnaiah Atmakur. "Molecular-Iodine-Promoted Synthesis of Dihydrobenzofuran-3,3-dicarbonitriles through a Novel Rearrangement." Synlett 30, no. 03 (2019): 293–98. http://dx.doi.org/10.1055/s-0037-1611706.

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The title compounds were synthesized from 5,5-dimethylcyclohexane-1,3-dione, benzaldehyde, and malononitrile promoted by molecular iodine in basic medium via 2-amino-7,7-dimethyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile, by a novel protocol. The protocol involves a novel rearrangement in which the 4H-chromene fragment dissociates to a cyclopropane moiety and rearranges to the five-membered compound 6,6-dimethyl-4-oxo-2-phenyl-4,5,6,7-tetrahydrobenzofuran-3,3(2H)-dicarbonitrile. Simple reaction conditions, excellent yields, and high compatibility are the advantages of this

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41

Shripad, Potadar *. and Ramling Kotnal. "THE DESIGN AND SYNTHESIS OF NOVEL DERIVATIVES OF 3-HYDROXY-1, 2, 3, 4-TETRAHYDROQUINOXALINE-2-CARBOHYDRAZIDE DERIVATIVES." Journal of Pharma Research 8, no. 5 (2019): 303–5. https://doi.org/10.5281/zenodo.3236677.

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<strong><em>ABSTRACT</em></strong> <strong><em>O</em></strong><em>-Phenylenediamine reacts with diethyl malonate to form ethyl 3-oxo-1,2,3,4- tetrahydroquinoxaline-2-carboxylate 2, which reacts with hydrazinehydrate to form ethyl 3-oxo-1,2,3,4- tetrahydroquinoxaline-2-carboxylate 3. Compound 3 on condensation with different aromatic aldehydes gives of 3-hydroxy-1, 2, 3, 4-tetrahydroquinoxaline-2-carbohydrazide. And The structures of these compounds are confirmed by <sup>1</sup>H NMR and LC-MS data.</em> <strong><em>KEYWORDS:</em></strong><em> Quinoxaline, Manolicacid, Hydrazinehydrate.</em>

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42

Powell, W. S., R. J. MacLeod, S. Gravel, F. Gravelle, and A. Bhakar. "Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils." Journal of Immunology 156, no. 1 (1996): 336–42. http://dx.doi.org/10.4049/jimmunol.156.1.336.

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Abstract 5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a recently discovered metabolite of arachidonic acid that activates human neutrophils by a mechanism independent of the receptor for leukotriene B4 (LTB4). The objectives of this study were to identify the major metabolites of 5-oxo-ETE in neutrophils and to compare the biologic activities of 5-oxo-ETE with those of its metabolites and other 5-oxoeicosanoids. Neutrophils rapidly converted 5-oxo-ETE to its omega-oxidation product, 5-oxo-20-hydroxy-6E,8Z,11Z,14Z- eicosatetraenoic acid. This compound was nearly 100 times less potent th

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43

Berger, Raphael J. F., Surajit Jana, Roland Fröhlich, and Norbert W. Mitzel. "Basic Beryllium ortho-Fluorobenzoate and its Mono-hydroxo Derivative." Zeitschrift für Naturforschung B 66, no. 11 (2011): 1131–35. http://dx.doi.org/10.1515/znb-2011-1108.

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The preparation of tetraberyllium-μ4-oxo-hexa[η2-(ortho-fluorobenzoate)] [Be4O(o-C6H4FCOO) 6, 2] and tetraberyllium-μ4-oxo-μ2-hydroxo-penta[η2-(ortho-fluorobenzoate)] [Be4(o-C6H4F-COO)5(OH), 3] from silver ortho-fluorobenzoate and BeCl2 in Et2O/thf solution containing varying amounts of water is reported. The single-crystal structures of 2·tetrahydrofuran and 3·Et2O·2 hexane are discussed in comparison with the structure of the known basic beryllium and zinc carboxylates [M4O(RCOO)6, M = Be, Zn]. DFT calculations show that lower symmetry has to be expected for Be-based M4O-framework-type compo

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44

Saxena, Nishtha, Anil Kumar, and Nivedita Srivastava. "Computational Studies of N-1 Substituted Quinolone Derivatives as Potent Inhibitors of Gyr B subunit of Escherichia coli K-12." Oriental Journal Of Chemistry 38, no. 2 (2022): 465–69. http://dx.doi.org/10.13005/ojc/380232.

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It has been confirmed that 4-Quinolone derivatives associated with p- toluene sulphonamide group at 3 position are having bactericidal activity10. We have synthesized various derivatives of 1,4-dihydro-4-oxo-3-[1-oxo-2-hydrazino-3-{p-toluenenesulfon}] quinolines. These compounds were synthesized by the reaction of substituted quinolone carbohydrazide derivatives 1a,b with p-toluene sulphonyl chloride in the presence of pyridine base. The compound was purified and characterized by IR, NMR (H1 and C13) and HRMS studies. Here we have conducted molecular docking of compounds 2a and 2b to explore t

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45

Gakovic, Andrea, Maja Djurendic-Brenesel, Evgenija Djurendic, Katarina Penov-Gasi, and Marija Sakac. "Synthesis of some 16,17-secoandrost-5-ene derivatives." Chemical Industry 64, no. 2 (2010): 81–84. http://dx.doi.org/10.2298/hemind100212009g.

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Starting from 3?-acetoxy-17-oxo-16,17-secoandrost-5-ene-16-nitrile (1), 3?-acetoxy-16,17-secoandrost-5-ene-16-nitrile (4) was synthesized by a three-stage procedure. First, the formyl group of compound 1 was reduced, to yield the alcohol 2. Compound 2 was further transformed to the mesyloxy derivative 3, whose reduction with NaBH3CN gave compound 4. Apart from compound 4 as the main reaction product, two additional products were obtained, for which the GC/MS analysis suggested that they are 8(14) and 14 derivatives of compound 4. Compound 4 was transformed into 3?-hydroxy-16,17-sesoandrost-5-e

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46

Wu, Yue-Hua, Gao-Keng Xiao, Guo-Dong Chen, et al. "Pericocins A–D, New Bioactive Compounds from Periconia sp." Natural Product Communications 10, no. 12 (2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001228.

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One new dihydroisocoumarin, pericocin A (1), one new chromone, pericocin B (2), and two new α-pyrone derivatives, pericocins C-D (3–4), together with two known compounds, 3-(2-oxo-2 H-pyran-6-yl)propanoic acid (5) and ( E)-3-(2-oxo-2 H-pyran-6-yl)acrylic acid (6), were isolated from the culture of the endolichenic fungus Periconia sp.. Their structures were elucidated by spectroscopic methods. All these compounds are derived from the polyketone biosynthetic pathway. Compound 1 was obtained as a mixture of enantiomers. The antimicrobial activity of compounds 1–5 was tested against Escherichia c

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47

Sutoh, Yuichi, Yuko Okawamukai, Satoshi Nishino, and Yuzo Nishida. "Structure of a New Tetranuclear Iron(III) Complex with an Oxo-Bridge; Factors to Govern Formation and Stability of Oxo-Bridged Iron(III) Species in the L-Subunit of Ferritin." Zeitschrift für Naturforschung C 61, no. 1-2 (2006): 149–54. http://dx.doi.org/10.1515/znc-2006-1-226.

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Abstract We have investigated the reaction products of several iron(III) compounds with hydrogen peroxide, and have found that hydrogen peroxide promotes the formation of an oxo-bridged iron(III) species in the presence of methanol (electron donor), and carboxyl groups of the ligand systems play a role to give the tetranuclear iron(III) compound containing a bent Fe- O-Fe unit (O: oxo oxygen atom). Based on the present results and the facts that L-chains of human ferritins lack ferroxidase activity, but are richer in carboxyl groups (glutamates) exposed on the cavity surface, it seems reasonab

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48

Luo, Yong Ming, Xiao Yin Yin, and Ming Yong Xie. "Chemical Constituents and Bioactivity of Chloranthus Multistachys." Advanced Materials Research 343-344 (September 2011): 1189–92. http://dx.doi.org/10.4028/www.scientific.net/amr.343-344.1189.

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From Chloranthus multistachys, three sesquiterpene lactones, multislactone (1), codonolactone(2), lasianthuslactone A(3), and three diterpenes, 12R,15- dihydroxylabda-8(17), 13E- dien-19-oic acid(4), 12(S),15- dihydroxy labda-8(17), 13E-dien- 19-oic acid(5), 12-oxo-15- hydroxylabda-8(17), 13E-dien-19-oic acid(6) were isolated. The structures of the isolated compounds were established by means of NMR and MS analyses. Compound 1~6 were firstly isolated from this plant. Compound 1 is new natural products. Among them , compound 1 and 6 show anti- inflammatory activities.

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Corrêa, Rodrigo S., Lucienir P. Duarte, Grácia D. F. Silva, Djalma M. de Oliveira, Javier Ellena та Antônio C. Doriguetto. "16α-Hydroxyfriedelin and 3-Oxo-16-methylfriedel-16-ene as Building Blocks: Crystal Structure and Hirshfeld Surfaces Decoding Intermolecular Contacts". Journal of Crystallography 2013 (24 жовтня 2013): 1–6. http://dx.doi.org/10.1155/2013/539163.

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In this paper the importance of C–H⋯O intermolecular hydrogen bonds and van der Waals forces in crystal packing stabilization of 16α-hydroxyfriedelin (1) and 3-oxo-16-methylfriedel-16-ene (2) is described. Compound 1 is a natural product isolated from the hexane extract of Salacia elliptica branches, whereas compound 2 is obtained from compound 1 after dehydration accompanied by methyl migration of C-17 to C-16. The single-crystal X-ray diffraction experiments for 1 and 2 were carried out at 150 K, and the crystallographic study demonstrated that these compounds crystallize in noncentrosymmetr

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50

Reis, Joana, Alexandra Gaspar, Fernanda Borges, Ligia R. Gomes, and John Nicolson Low. "4-Oxo-N-phenyl-4H-chromene-2-carboxamide and of a new polymorph of 7-methoxy-4-oxo-N-p-tolyl-4H-chromene-2-carboxamide and its hemihydrate." Acta Crystallographica Section C Crystal Structure Communications 69, no. 12 (2013): 1527–33. http://dx.doi.org/10.1107/s0108270113029727.

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4-Oxo-N-phenyl-4H-chromene-2-carboxamide, C16H11NO3, crystallizes in the space groupP21/nand its derivative 7-methoxy-4-oxo-N-p-tolyl-4H-chromene-2-carboxamide, C18H15NO4, forms two polymorphs which crystallize in the space groupsP21/candP\overline{1}. The structures have ananti-rotamer conformation about the C—N bond; however, the amide O atom can be eithertrans- orcis-related to the O atom of the pyran ring. The latter compound also crystallizes as a hemihydrate, C18H15NO4·0.5H2O, in the space groupC2/c. This compound has a similar structure to that of the unsolvated compound.

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