Academic literature on the topic 'Oxyntomoduline'

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Journal articles on the topic "Oxyntomoduline"

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Uesaka, Toshihiro, Keiichi Yano, Seiji Sugimoto, and Masaaki Ando. "Glucagon-like peptide isolated from the eel intestine: effects on atrial beating." Journal of Experimental Biology 204, no. 17 (2001): 3019–26. http://dx.doi.org/10.1242/jeb.204.17.3019.

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SUMMARYA new glucagon-like peptide was isolated from the intestine of the eel Anguilla japonica. The primary structure was determined by sequence analysis after cleavage with lysyl endopeptidase, quantitative amino acid analysis and fast atom bombardment mass spectrometry as HSQGTFTNDY10SKYLETRRAQ20DFVQWLMNSK30RSGGPT. Since its structure is similar to that of oxyntomodulins (OXMs) reported in various vertebrates, we named this peptide eel oxyntomodulin (eOXM). We found that eOXM enhanced the contractile force and the beating rate of the eel atrium in a dose-dependent manner. These effects of e
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Druce, Maralyn R., and Stephen R. Bloom. "Oxyntomodulin." Treatments in Endocrinology 5, no. 5 (2006): 265–72. http://dx.doi.org/10.2165/00024677-200605050-00001.

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Druce, Maralyn, and Mohammad Ghatei. "Oxyntomodulin." Current Opinion in Endocrinology & Diabetes 13, no. 1 (2006): 49–55. http://dx.doi.org/10.1097/01.med.0000200526.08653.bb.

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Patterson, Michael, Kevin G. Murphy, Sejal R. Patel, et al. "Hypothalamic Injection of Oxyntomodulin Suppresses Circulating Ghrelin-Like Immunoreactivity." Endocrinology 150, no. 8 (2009): 3513–20. http://dx.doi.org/10.1210/en.2008-0796.

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Ghrelin is a gastric peptide that regulates appetite and GH secretion. Circulating ghrelin levels are elevated by fasting and suppressed postprandially. However, the mechanisms regulating circulating ghrelin levels are unclear. Oxyntomodulin is an anorexic peptide hormone released from L cells in the gut. We investigated the effects of intracerebroventricular (icv) administration of oxyntomodulin on circulating ghrelin levels. The icv administration of 1, 3, or 10 nmol oxyntomodulin reduced circulating acylated and total (acylated and des-acylated) ghrelin 60 min after icv injection. Administr
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Stepanenko, V. N., R. S. Esipov, A. I. Gurevich, L. A. Chupova, and A. I. Miroshnikov. "Recombinant oxyntomodulin." Russian Journal of Bioorganic Chemistry 33, no. 2 (2007): 227–32. http://dx.doi.org/10.1134/s1068162007020045.

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Bak, Monika J., Nicolai Wewer Albrechtsen, Jens Pedersen, et al. "Specificity and sensitivity of commercially available assays for glucagon and oxyntomodulin measurement in humans." European Journal of Endocrinology 170, no. 4 (2014): 529–38. http://dx.doi.org/10.1530/eje-13-0941.

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AimTo determine the specificity and sensitivity of assays carried out using commercially available kits for glucagon and/or oxyntomodulin measurements.MethodsTen different assay kits used for the measurement of either glucagon or oxyntomodulin concentrations were obtained. Solutions of synthetic glucagon (proglucagon (PG) residues 33–61), oxyntomodulin (PG residues 33–69) and glicentin (PG residues 1–69) were prepared and peptide concentrations were verified by quantitative amino acid analysis and a processing-independent in-house RIA. Peptides were added to the matrix (assay buffer) supplied
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Pendharkar, Sayali, Ruma Singh, Aya Cervantes, Steve DeSouza, Sakina Bharmal, and Maxim Petrov. "Gut Hormone Responses to Mixed Meal Test in New-Onset Prediabetes/Diabetes After Acute Pancreatitis." Hormone and Metabolic Research 51, no. 03 (2018): 191–99. http://dx.doi.org/10.1055/a-0802-9569.

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AbstractThe study was aimed to investigate gut hormone responses to mixed meal test in individuals with new-onset prediabetes or diabetes after acute pancreatitis (cases) compared with healthy controls, and the effect of body fat parameters. A total of 29 cases and 29 age- and sex-matched healthy controls were recruited. All participants were given standard mixed meal drink and blood samples were collected to measure dipeptidyl peptidase IV, gastric inhibitory peptide, glucagon like peptide-1, insulin, oxyntomodulin, and peptide YY. Body fat parameters were measured using magnetic resonance im
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Stanley, Sarah, Katie Wynne, and Steve Bloom. "Gastrointestinal Satiety Signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide." American Journal of Physiology-Gastrointestinal and Liver Physiology 286, no. 5 (2004): G693—G697. http://dx.doi.org/10.1152/ajpgi.00536.2003.

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Many peptides are synthesized and released from the gastrointestinal tract and pancreas, including pancreatic polypeptide (PP) and the products of the gastrointestinal L cells, glucagon-like peptide 1 (GLP-1), oxyntomodulin, and peptide YY (PYY). Whereas their roles in regulation of gastrointestinal function have been known for some time, it is now evident that they also influence eating behavior. This review considers the anorectic peptides PYY, PP, GLP-1, and oxyntomodulin, which decrease appetite and promote satiety in both animal models and humans.
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Schjoldager, Birgit, Poul Erik Mortensen, John Myhre, John Christiansen, and Jens Juul Holst. "Oxyntomodulin from distal gut." Digestive Diseases and Sciences 34, no. 9 (1989): 1411–19. http://dx.doi.org/10.1007/bf01538078.

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Lee, Anita Y. H., Derek L. Chappell, Monika J. Bak, et al. "Multiplexed Quantification of Proglucagon-Derived Peptides by Immunoaffinity Enrichment and Tandem Mass Spectrometry after a Meal Tolerance Test." Clinical Chemistry 62, no. 1 (2016): 227–35. http://dx.doi.org/10.1373/clinchem.2015.244251.

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Abstract BACKGROUND Proglucagon-derived peptides (PGDPs), which include glucagon-like peptide (GLP)-1, glucagon, and oxyntomodulin, are key regulators of glucose homeostasis and satiety. These peptide hormones are typically measured with immuno-based assays (e.g., ELISA, RIA), which often suffer from issues of selectivity. METHODS We developed a multiplexed assay for measuring PGDPs including GLP-1 (7–36) amide, GLP-1 (9–36) amide, glucagon, and oxyntomodulin by mass spectrometry and used this assay to examine the effect of a meal tolerance test on circulating concentrations of these hormones.
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Dissertations / Theses on the topic "Oxyntomoduline"

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RIBARD, DIDIER. "Effet inhibiteur de l'octapeptide c-terminal de l'oxyntomoduline sur la secretion acide gastrique stimulee par la pentagastrine chez l'homme." Montpellier 1, 1989. http://www.theses.fr/1989MON11040.

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Ferroudji, Sai͏̈d. "Effet inhibiteur de l'octapeptide C-terminal de l'oxyntomoduline sur la sécrétion acide gastrique stimulée par la pentagastrine chez l'homme : essai d'étude dose-effet." Montpellier 1, 1990. http://www.theses.fr/1990MON11196.

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Rodier, Geneviève. "Effet et mode d'action de la glicentine et de l'oxyntomoduline sur les cellules musculaires lisses gastriques (doctorat : systeme de communications intercellulaires en endocrinologie)." Aix-Marseille 2, 1998. http://www.theses.fr/1998AIX2660U.

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Le, Quellec Alain. "Les peptides de la famille de l'Oxyntomoduline : mise en évidence d'une activité hormonale chez l'homme sain, comportement en pathologie humaine." Montpellier 1, 1994. http://www.theses.fr/1994MON1T003.

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Minnion, James Stephen. "Characterisation of oxyntomodulin and development of an oxyntomodulin analogue for use in metabolic research studies." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/11508.

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Price, Samantha. "Engineering an oxyntomodulin analogue for weight reduction." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/54898.

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There is currently a lack of safe and effective treatments for obesity. The administration of long acting analogues of satiety gut hormones has been suggested as a potential weight loss pharmacotherapy. The gut hormone oxyntomodulin is a natural dual agonist that generates weight loss by reducing food intake and increasing energy expenditure; effects which are believed to be mediated by the GLP-1 receptor and glucagon receptor respectively. Previously designed long acting oxyntomodulin analogues have limited potency compared to native glucagon and GLP-1, due to the addition of large molecules
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Park, Adrian John. "The role of oxyntomodulin and peptide YY₃₋₃₆ in energy homeostasis." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429599.

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Wynne, Katie-Jane. "The role of the gut hormone oxyntomodulin in the regulation of body-weight." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/7658.

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Halter, Bailey Anne. "Effects of exogenous and endogenous factors on appetite regulation in broiler chicks and Japanese quail." Thesis, Virginia Tech, 2021. http://hdl.handle.net/10919/103601.

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Understanding how appetite is regulated, via exogenous or endogenous factors, is essential to animal agriculture in order to maximize production capabilities, as well as in human medicine to generate ways to treat conditions such as eating disorders or obesity. The aim of this thesis was to evaluate the effects of ferulic acid (FA), an exogenous factor found within plant cells, and oxyntomodulin (OXM), an endogenous hormone generated in the gastrointestinal tract, on food intake in avian models, as well as elucidate the hypothalamic mechanisms responsible. In broiler chicks (Gallus gallus), FA
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Andersson, Jeanette. "Finns det något värde i att mäta Peptide tyrosine tyrosine, Glucose-dependent insulinotropic polypeptide och Oxyntomodulin postprandialt vid måltidsstudier?" Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-45009.

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Övervikt och fetma sprider sig likt en epidemi över världen. Omkring 1,9 miljarder vuxna varöverviktiga år 2014 och av dessa klassificerades 600 miljoner som feta. Forskning kring fetmas uppkomst och nya former av behandlingsalternativ pågår. En viktig faktor för uppkomst av övervikt är aptitreglering, där t.ex. Peptide tyrosine tyrosine (PYY), Oxyntomodulin (OXM) och Glucosedependent insulinotropic polypeptide (GIP) har betydelse. En litteraturstudie genomfördes där totalt nio originalartiklar från PubMed utvärderades. Syftet var att undersöka om det finns något värde i att mäta dessa hormon
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Book chapters on the topic "Oxyntomoduline"

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Bataille, D. "Oxyntomodulin and Its Related Peptides." In Glucagon III. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61150-6_19.

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Sheng, Shu-Li, Xiao-Hong Wang, and Yong-Mei Zhao. "The importance of C terminal peptide (KA8) of oxyntomodulin (OM) on OM bioactivities." In Peptides. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-010-9069-8_51.

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AhrÉn, Bo. "Oxyntomodulin." In Encyclopedia of Hormones. Elsevier, 2003. http://dx.doi.org/10.1016/b0-12-341103-3/00227-8.

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"Oxyntomodulin." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_12079.

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"Oxyntomodulin." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_312842.

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Holst, Jens Juul, Carolyn F. Deacon Bolette Hartmann, and Jens Pedersen. "GLP 1/2, Enteroglucagon, Glicentin, and Oxyntomodulin." In Handbook of Biologically Active Peptides. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-385095-9.00168-8.

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HOLST, JENS JUUL. "Glucagonlike Peptides 1 and 2, Enteroglucagon, Glicentin, and Oxyntomodulin." In Handbook of Biologically Active Peptides. Elsevier, 2006. http://dx.doi.org/10.1016/b978-012369442-3/50148-3.

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