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Journal articles on the topic 'Ozone antimicrobial activity endodontics'

Author: Grafiati

Published: 3 June 2025

Last updated: 20 July 2025

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1

Pereira, Marcio Ricardo Silva, Aníbal de Freitas Santos Júnior, Daniele Brustolim, Luiz Eduardo Lacerda de Oliveira, and Bruno Antônio Veloso Cerqueira. "Evaluation of antimicrobial activity in contaminated root canals and cytotoxicity of ozonized products: an ex-vivo study." Concilium 24, no. 8 (2024): 471–95. http://dx.doi.org/10.53660/clm-3335-24h42.

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Pulp and periapical diseases originate from microbial colonization of root canals. The development of new technologies and instrumentation techniques has provided more effective shaping of the root canal system. Even so, sodium hypochlorite and calcium hydroxide remain examples of auxiliary substances for endodontic treatment. Recently, ozone has emerged as promising in endodontic therapy. This study evaluated the antimicrobial activity of ozonized water and ozonized oils in root canals infected with Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans, in

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Kovacevska, Ivona, and Natasa Longurova. "USE OF OZONE IN RESTORATIVE DENTISTRY AND ENDODONTICS." Knowledge International Journal 34, no. 4 (2019): 817–22. http://dx.doi.org/10.35120/kij3404817k.

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The use of ozone in dentistry was suggested because of its antimicrobial, disinfectant, biocompatibility and therapeutic properties. In the last decade, the number of therapeutic ozone fluids has been detected to present frequent dental infections associated with periodontal disease, endodontic treatments and cavities. Despite these advantages, ozone therapy in dentistry is limited due to possible side effects. Therefore, dentists should know about the proper use of ozone therapy that can provide better patient care and significantly reduce the time and costs of treatment. The ozone is success

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3

Rodrigues, Fabricia de Souza, and Paulo Ricardo Carvalho Dos Santos. "O USO DA OZONIOTERAPIA EM ENDODONTIA: UMA REVISÃO NARRATIVA DA LITERATURA." Revista ft 28, no. 139 (2024): 50–51. http://dx.doi.org/10.69849/revistaft/ch10202410311750.

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Introduction: Ozone, a powerful oxidizing agent, has antimicrobial, analgesic and anti-inflammatory properties, making it a promising alternative in dentistry, especially in endodontics. Objectives: This study aims to review the literature on the use of ozone therapy as an adjuvant therapy in the disinfection of root canals. Materials and Methods: A narrative review of scientific articles published between 2020 and 2024 was carried out, using databases such as PubMed, SciELO, LILACS and Google Scholar. Nine relevant articles focusing on the application of ozone in endodontics were selected. Di

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Gomes, Brenda P. F. A., Morgana E. Vianna, Alexandre A. Zaia, José Flávio A. Almeida, Francisco J. Souza-Filho, and Caio C. R. Ferraz. "Chlorhexidine in Endodontics." Brazilian Dental Journal 24, no. 2 (2013): 89–102. http://dx.doi.org/10.1590/0103-6440201302188.

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Chemical auxiliary substances (CAS) are essential for a successful disinfection and cleanness of the root canals, being used during the instrumentation and if necessary, as antimicrobial intracanal medicaments. Different CAS have been proposed and used, among which sodium hypochlorite (NaOCl), chlorhexidine (CHX), 17% EDTA, citric acid, MTAD and 37% phosphoric acid solution. CHX has been used in Endodontics as an irrigating substance or intracanal medicament, as it possesses a wide range of antimicrobial activity, substantivity (residual antimicrobial activity), lower cytotoxicity than NaOCl w

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Dogandziyska, Violeta. "Antimicrobial Activity of Laser Systems in Endodontics." International Journal of Science and Research (IJSR) 10, no. 11 (2021): 286–89. https://doi.org/10.21275/sr211103053419.

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Heal, Talk Dental Journal. "Chlorhexidine in Endodontics-II." Heal Talk - A Journal of Clinical Dentitsry 16, no. 05 (2024): 13–14. https://doi.org/10.5281/zenodo.12590706.

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SubstantivityThe effectiveness of Chlorhexidine stems from its capacity to absorb to negatively charged surfaces in the mouth (e.g. tooth, mucosa, pellicle, restorative materials), being slowly released from these retention sites and therefore maintaining prolonged antimicrobial activity for several hours. This process is known as substantivity, and only chlorhexidine and tetracycline have this property so far.    Regarding its substantivity, it has been found that the use of chlorhexidine as root canal irrigating substance prevented microbial activity from 48 hrs, 7 days (in the liq

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Mohammadi, Z., S. Shalavi, and M. Yazdizadeh. "Antimicrobial Activity of Calcium Hydroxide in Endodontics: A Review." Chonnam Medical Journal 48, no. 3 (2012): 133. http://dx.doi.org/10.4068/cmj.2012.48.3.133.

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Tamilselvi, Ramachandran, Maniarasu Kalaiarasi, M. Elumalai, Thanthoni Malarkodi, Alagarswamy Venkatesh, and Venkatachalam Prakash. "Antimicrobial Activity of Metal Oxide Nanoparticles." Biomedical and Pharmacology Journal 17, no. 3 (2024): 1757–67. http://dx.doi.org/10.13005/bpj/2981.

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A broad range of gram positive and gram negative bacteria have been demonstrated to be effectively suppressed in growth by Metal Oxide Nanoparticles (MONPs), suggesting that these particles may be useful in the fight against antibiotic resistance. The antibacterial characteristics of MONPs, including those of silver, zinc, titanium, zirconia, iron, copper, magnesium, and cobalt oxide are widely recognized. The use of these nanoparticles made of synthetic and natural materials in dentistry is developing quickly, has been included in a variety of dental materials and has assisted in the treatmen

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Chohan, Hitesh, Sanjana Khullar, Ria H. Patel, Jyotirmayee Rath, Sameera Mohammed, and Savadamoorthi Kamatchi Subramani. "Investigations of the Antimicrobial Effectiveness of Different Disinfection Protocols Against Endodontic Pathogens in Root Canal Systems." Journal of Pharmacy and Bioallied Sciences 16, Suppl 4 (2024): S3577—S3579. https://doi.org/10.4103/jpbs.jpbs_1116_24.

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ABSTRACT Objective: To compare the antimicrobial effectiveness of erbium-doped yttrium-aluminum-garnet (Er: YAG) laser, ozone therapy, photodynamic therapy (PDT), and sodium hypochlorite against endodontic pathogens. Methods: Standardized root canal models inoculated with Enterococcus faecalis, Pseudomonas aeruginosa, and Candida albicans were treated with Er: YAG laser, 5.25% NaOCl, ozone, or PDT with methylene blue. Microbial loads, treatment time, and depth of penetration were assessed. Results: Er: YAG laser demonstrated the highest efficacy against Enterococcus faecalis and Pseudomonas ae

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Silva, Elane Lima da, Beatriz Silveira de Morais, and Flavia Darius Vivacqua. "Association of Ozoniotherapy to Endodontics, aiming at the tissue repair of periapical lesions - a literature review / Associação da Ozonioterapia à Endodontia, visando o reparo tecidual de lesões periapicais – uma revisão de literatura." BRAZILIAN APPLIED SCIENCE REVIEW 6, no. 4 (2022): 1292–304. http://dx.doi.org/10.34115/basrv6n4-005.

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Introduction: The success of endodontic treatment is related to the cleaning and elimination of microorganisms and their by-products present in root canals for periapical tissue repair. Objective: To verify the efficacy of ozone (O3) as an adjunct in the therapeutic protocol of Endodontics, aiming to assist in tissue repair of periapic lesions. Methods: This is a literature review, in which scientific articles were researched, from the last 10 years, using the databases of pubmed, scielo, vhl and EBSCOhost platforms, and applying the keywords: "Ozone", "Dentistry", "Endodontics" and "Complemen

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Russo, Carla, Giuseppe Curcio, Alessandro Graziani, Antonella Mencacci, and Donatella Pietrella. "Antibiofilm, Anti-Inflammatory, and Regenerative Properties of a New Stable Ozone-Gel Formulation." Pharmaceutics 16, no. 12 (2024): 1580. https://doi.org/10.3390/pharmaceutics16121580.

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Background/Objectives: Chronic skin wounds are characterized by inflammation, persistent infections, and tissue necrosis. The presence of bacterial biofilms prolongs the inflammatory response and delays healing. Ozone is a potent antimicrobial molecule, and many formulations have been used in the advanced therapeutic treatment of chronic wounds. The aim of this work was to determine the antimicrobial, anti-inflammatory, and regenerative activity of a stable ozone-gel formulation over time. Methods: The antimicrobial property was assessed by measuring the minimal inhibitory concentration and th

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Zancan, Rafaela Fernandes, Bruno Cavalini Cavenago, Denise Ferracioli Oda, Clovis Monteiro Bramante, Flaviana Bombarda de Andrade, and Marco Antonio Hungaro Duarte. "Antimicrobial Activity and Physicochemical Properties of Antibiotic Pastes Used In Regenerative Endodontics." Brazilian Dental Journal 30, no. 6 (2019): 536–41. http://dx.doi.org/10.1590/0103-6440201902613.

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Abstract: The purpose of this study was to evaluate the pH, solubility and antimicrobial action of Calcium Hydroxide Paste (CH), Double Antibiotic Paste (metronidazole+ciprofloxacin-DAP), calcium hydroxide added to DAP (CH/DAP) and Triple Antibiotic Paste (metronidazole + ciprofloxacin+minocycline-TAP). pH (n=10) were measured by pHmeter. Root canals of acrylic teeth (n=10) were filled with the above-mentioned intracanal-dressings, immersed in ultrapure water, and solubility was measured by the difference between the initial and final volume (7,15 and 30 days) by using micro-computed tomograph

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Baghdadi, Loujain Fahad, Tariq Awadh Alshehri, Habib Ali Reda, Layla Ahmed Aldawood, Maria Hassan Abualsaud, and Hassan Mushabbab Alamer. "Role of Triple Antibiotic Paste in Regenerative Endodontics." JOURNAL OF HEALTHCARE SCIENCES 04, no. 12 (2024): 729–35. https://doi.org/10.52533/johs.2024.41213.

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Triple Antibiotic Paste (TAP), a combination of ciprofloxacin, metronidazole, and minocycline, plays a pivotal role in regenerative endodontics by providing effective antimicrobial action and creating an environment conducive to tissue regeneration. Its broad-spectrum activity targets diverse microbial populations, including biofilms, within the root canal system. This makes TAP particularly valuable in treating immature teeth with necrotic pulp, facilitating continued root development through stem cell recruitment, angiogenesis, and dentin-pulp tissue formation. The mechanism of TAP’s action

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Muniz, Ana Bessa, Mariana Raquel da Cruz Vegian, Lady Daiane Pereira Leite, et al. "Non-Thermal Atmospheric Pressure Plasma Application in Endodontics." Biomedicines 11, no. 5 (2023): 1401. http://dx.doi.org/10.3390/biomedicines11051401.

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The failure of endodontic treatment is frequently associated with the presence of remaining microorganisms, mainly due to the difficulty of eliminating the biofilm and the limitation of conventional irrigation solutions. Non-thermal atmospheric pressure plasma (NTPP) has been suggested for many applications in the medical field and can be applied directly to biological surfaces or indirectly through activated liquids. This literature review aims to evaluate the potential of NTPP application in Endodontics. A search in the databases Lilacs, Pubmed, and Ebsco was performed. Seventeen manuscripts

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Araújo, Matéus Simplício, Yann Nobre Viana, Joelson Pessoa Dantas, et al. "Ozone's Antimicrobial Potential: A Review Article." Archives of Current Research International 25, no. 4 (2025): 132–43. https://doi.org/10.9734/acri/2025/v25i41143.

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Objective: The importance of investigating new products with antimicrobial activity (AA) is based on the constant increase in the frequency of reports of antimicrobial resistance that hinder the treatment of human infections. This integrative literature review aimed to investigate the potential antimicrobial activity (AA) of O3 and elucidate its importance in the context of the need for bioprospecting of new antimicrobial agents. Methodology: For this purpose, a search for articles published between July 2014 and July 2024 was carried out in the PubMed, Scielo and Cocharne databases. Four keyw

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Saliminasab, Mina. "Applications of Nanoparticles in Endodontics as an Antibacterial Agent: A Minireview." Advances in Applied NanoBio-Technologies 6, no. 2 (2025): 46–54. https://doi.org/10.18502/aanbt.v6i2.18554.

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In root canal treatment, removing persistent bacterial biofilm is challenging. Currently, with nanoparticles (NPs) that have antimicrobial activity, we can address this issue. These particles can eliminate the microbes through these actions, including destroying the bacterial wall, increasing cell membrane permeability, stimulating the production of ROS, and avoiding deoxyribonucleic acid replication. So, they could provide good results to have a better prognosis for endodontic treatments. This minireview provides a brief review of NPs ’ mechanisms of action and recent advancements in their ap

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Khoury, Rayana Duarte, Lara Steffany de Carvalho, Mauro Felipe Rios do Nascimento, Fadi Alhussain, and Amjad Abu Hasna. "Endodontic irrigants from a comprehensive perspective." World Journal of Clinical Cases 12, no. 21 (2024): 4460–68. http://dx.doi.org/10.12998/wjcc.v12.i21.4460.

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This review article explores the fundamental principles of modern endodontics with a focus on root canal cleaning and shaping. It reviews commonly used endodontic irrigant, namely sodium hypochlorite (NaOCl), herbal extracts, chlorhexidine (CHX), and chelating agents, highlighting their properties, applications, and potential drawbacks. NaOCl, a key antimicrobial agent, demonstrates effectiveness against various microorganisms but poses challenges such as high cytotoxicity. Herbal extracts, gaining recognition in endodontics, present an alternative with potential advantages in preserving denti

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Dong, Xu, and Xin Xu. "Bioceramics in Endodontics: Updates and Future Perspectives." Bioengineering 10, no. 3 (2023): 354. http://dx.doi.org/10.3390/bioengineering10030354.

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Bioceramics, with excellent bioactivity and biocompatibility, have been widely used in dentistry, particularly in endodontics. Mineral trioxide aggregate (MTA) is the most widely used bioceramic in endodontics. Recently, many new bioceramics have been developed, showing good potential for the treatment of endodontic diseases. This paper reviews the characteristics of bioceramics and their applications in various clinical endodontic situations, including root-end filling, root canal therapy, vital pulp therapy, apexification/regenerative endodontic treatment, perforation repair, and root defect

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LEONARDO, M., L. DASILVA, M. FILHO, K. BONIFACIO, and I. ITO. "In Vitro Evaluation of Antimicrobial Activity of Sealers and Pastes Used in Endodontics." Journal of Endodontics 26, no. 7 (2000): 391–94. http://dx.doi.org/10.1097/00004770-200007000-00003.

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Xiao, Suli, Guanwen Sun, Shan Huang, Chen Lin, and Yijun Li. "Nanoarchitectonics-Based Materials as a Promising Strategy in the Treatment of Endodontic Infections." Pharmaceutics 16, no. 6 (2024): 759. http://dx.doi.org/10.3390/pharmaceutics16060759.

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Endodontic infections arise from the interactive activities of microbial communities colonizing in the intricate root canal system. The present study aims to update the latest knowledge of nanomaterials, their antimicrobial mechanisms, and their applications in endodontics. A detailed literature review of the current knowledge of nanomaterials used in endodontic applications was performed using the PubMed database. Antimicrobial nanomaterials with a small size, large specific surface area, and high chemical activity are introduced to act as irrigants, photosensitizer delivery systems, and medi

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Kanagasingam, Shalini, and Igor R. Blum. "Sodium Hypochlorite Extrusion Accidents: Management and Medico-Legal Considerations." Primary Dental Journal 9, no. 4 (2020): 59–63. http://dx.doi.org/10.1177/2050168420963308.

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Sodium hypochlorite is considered the most widely used irrigant in endodontics as it exhibits effective antimicrobial activity and has potent tissue-dissolving ability. Whilst it is considered safe when used within the confines of the root canal system, it can cause serious complications when inadvertent periradicular extrusion occurs. This article outlines the complications of sodium hypochlorite extrusion and reviews the appropriate management based on the contemporary evidence. Preventive measures are suggested and the relevant medico-legal considerations are outlined.

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Mohammadi, Zahed, Sousan Shalavi, Amir Moeintaghavi, and Hamid Jafarzadeh. "A Review Over Benefits and Drawbacks of Combining Sodium Hypochlorite with Other Endodontic Materials." Open Dentistry Journal 11, no. 1 (2017): 661–69. http://dx.doi.org/10.2174/1874210601711010661.

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Introduction:As the root canal system considered to be complex and unpredictable, using root canal irrigants and medicaments are essential in order to enhance the disinfection of the canal. Sodium hypochlorite is the most common irrigant in endodontics. Despite its excellent antimicrobial activity and tissue solubility, sodium hypochlorite lacks some important properties such as substantivity and smear layer removing ability.Objective:The aim of this review was to address benefits and drawbacks of combining sodium hypochlorite with other root canal irrigants and medicaments.Discussion:Accordin

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Adham, Ayat H., Ahmed H. Ali, and Francesco Mannocci. "Continuous Chelation Concept in Endodontics." Journal of Baghdad College of Dentistry 34, no. 4 (2022): 59–69. http://dx.doi.org/10.26477/jbcd.v34i4.3287.

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Background:Continuous chelation can be defined as the concept of using a single mix of a weak chelator with NaOCL throughout the entire root canal preparation procedure without causing a reduction in the antimicrobial and proteolytic activity of NaOCL. Etidronic acid, also known as "1-Hydroxyethylidene-1, 1-Bisphosphonate" HEBP, or HEDP, is a soft biocompatible chelator utilized in direct combination with sodium hypochlorite to form an all-in-one deproteinizing, disinfecting, and chelating solution. It's the only chelator available as a certified commercial product, "Dual Rinse HEDP," approved

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Abraham-Millán, Yoneisy, Rosa María Montano-Silva, and Yaima Pupo-Martínez. "Use of irrigating substances of natural origin in Endodontics." Salud, Ciencia y Tecnología - Serie de Conferencias 2 (November 15, 2023): 591. http://dx.doi.org/10.56294/sctconf2023591.

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The success of pulpo-radicular treatment involves the complete cleaning, disinfection and conformation of the canal system, which depends on the elimination of vital or necrotic pulp tissue, dentinal remnants and microorganisms. For this, the use of irrigating solutions with antimicrobial, chelating, solvent and hemostatic activity is essential. There are biopharmaceutical products created for this purpose. The objective was: to analyze the irrigating substances of natural origin used in the treatment of endodontic canals, considering the importance of this knowledge for stomatologists. The me

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Patel, Shivam, Harpreet Hundal, Geeta Nishad, et al. "Antimicrobial activity of laser assisted endodontic therapy in disinfecting root canals." Bioinformation 20, no. 6 (2024): 610–14. http://dx.doi.org/10.6026/973206300200610.

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Light Amplified Stimulated Emission of Radiation (LASER) is nowadays widely studied regarding their use in endodontics and restorative dentistry. Therefore, it is of interest to evaluate the antibacterial activity of three types of LASERs namely CO2 LASER.Er, Cr:YSGG LASER and Diode LASER in disinfection of root canals. 70 patients (105 single rooted teeth) were included in the study. There was application of 2% Sodium Hypochlorite (NaOCl), 2780 nm Er,Cr:YSGG LASER, 900 nm Diode LASER and CO2 LASER. Microbial samples were collected from root canals both before and after the interventions throu

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Pina-Vaz, Irene, Joana Barros, Ana Dias, Miguel A. Rodrigues, Cidália Pina-Vaz, and Maria A. Lopes. "Antibiofilm and Antimicrobial Activity of Polyethylenimine: An Interesting Compound for Endodontic Treatment." Journal of Contemporary Dental Practice 16, no. 6 (2015): 427–32. http://dx.doi.org/10.5005/jp-journals-10024-1701.

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ABSTRACT Aim Bacteria levels of necrotic teeth are greatly reduced after endodontic treatment procedures but the presence of persisting microorganisms leads to continuous efforts to develop materials with antimicrobial properties. The purpose of the study was to determine the antimicrobial activity of polyethylenimine (PEI) against common bacteria and yeasts, regarding planktonic cells and biofilm, and to clarify its antimicrobial mechanism of action through flow cytometry. Materials and methods The antibiofilm and antimicrobial effect of PEI was determined against Enterococcus faecalis, Staph

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Abdelgawad, Raghda Magdy, Nailê Damé-Teixeira, Katarzyna Gurzawska-Comis, et al. "Pectin as a Biomaterial in Regenerative Endodontics—Assessing Biocompatibility and Antibacterial Efficacy against Common Endodontic Pathogens: An In Vitro Study." Bioengineering 11, no. 7 (2024): 653. http://dx.doi.org/10.3390/bioengineering11070653.

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Regenerative endodontics (REP) is a new clinical modality aiming to regenerate damaged soft and hard dental tissues, allowing for root completion in young adults’ teeth. Effective disinfection is crucial for REP success, but commonly used antimicrobials often harm the niche dental pulp stem cells (DPSCs). To our knowledge, this is the first study to explore the biocompatibility and antimicrobial potential of pectin as a potential natural intracanal medicament for REPs. Low methoxyl commercial citrus pectin (LM) (pectin CU701, Herbstreith&Fox.de) was used in all experiments. The pectin’s an

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Janini, Ana Cristina Padilha, Gabriela Fernanda Bombarda, Lauter Eston Pelepenko, and Marina Angélica Marcano. "Antimicrobial Activity of Calcium Silicate-Based Dental Materials: A Literature Review." Antibiotics 10, no. 7 (2021): 865. http://dx.doi.org/10.3390/antibiotics10070865.

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Endodontic biomaterials have significantly improved dental treatment techniques in several aspects now that they can be used for vital pulp treatments, as temporary intracanal medication, in definitive fillings, in apical surgeries, and for regenerative procedures. Calcium silicate-based cement is a class of dental material that is used in endodontics in direct contact with the dental structures, connective tissue, and bone. Because the material interacts with biological tissues and stimulates biomineralization processes, its properties are of major importance. The main challenge in endodontic

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Fernández-García, L. A., O. E. Ledea-Lozano, I. Fernández-Torres, et al. "Chemical characterization of sunflower oil oxidized by UV and ozone with different degrees of oxidation and study of their antimicrobial action." Grasas y Aceites 74, no. 4 (2024): e524. http://dx.doi.org/10.3989/gya.1107222.

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Oxidation by the action of ozone takes place at high rates and involves the reaction of ozone molecules with fatty acid double bonds followed by the formation of stable oxidation products with biological activity. In the present work, a comparative study on sunflower oil oxidized by ultraviolet (UV) light and ozone was carried out. This study involved the chemical characterization of sunflower oil oxidized by UV irradiation and ozonation, in addition to assessing the germicidal activity of oxidized oils obtained under various conditions. The results indicated that under the conditions studied,

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Raoof, Maryam, Mohammad H. Zadeh, Zahra E. Nejad, Fariba Sharififar, Mansooreh Khodashenas, and Rahim Fereidooni. "Antimicrobial Efficacy of Different Herbal Extracts against Root Canal Pathogens - An in Vitro Study." Indian Journal of Dental Research 34, no. 2 (2023): 204–8. http://dx.doi.org/10.4103/ijdr.ijdr_625_22.

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Background: The antimicrobial activity exhibited by the plant extracts against various pathogens has previously been demonstrated to a limited extent. However, the antibacterial effects of most of them have not yet been clarified in endodontics. Aim: This study aimed to determine the antimicrobial activity of some medicinal plants' methanolic extracts against some root canal microorganisms. Methods and Materials: In this in vitro study, after gathering the five plants (pomegranate peel, clove, Zhumeria majdae, Eucalyptus galbie and green tea), their methanolic extracts were obtained by the mac

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Piriyanga, Rathna, Manish Ranjan, Anand Sherwood, and Swathi Priyadharshini. "Hydrogel-Based Intracanal Medicaments in Endodontics: A Systematic Review of Development and Antibacterial Efficacy." Journal of International Oral Health 16, no. 6 (2024): 449–61. https://doi.org/10.4103/jioh.jioh_134_24.

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Abstract Background and Aim: Endodontic treatment necessitates the elimination of infectious pulp tissue and the disinfection of the root canal system to prevent reinfection and periradicular inflammation. Traditional intracanal medicaments, such as calcium hydroxide (Ca(OH)2), have limitations including limited drug diffusion, short retention time, and potential tooth discoloration. Hydrogels, due to their unique properties such as controlled drug release and biocompatibility, have emerged as promising carriers for intracanal medicaments. This systematic review aims to evaluate the developmen

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Junior, Jaci Simi, Ricardo Machado, Rafael Stiz, et al. "Antimicrobial activity of calcium hydroxide associated with a new vehicle (Triethanolamine)." Brazilian Dental Science 19, no. 1 (2016): 43. http://dx.doi.org/10.14295/bds.2016.v19i1.1179.

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<p><strong>Objective:</strong> The aim of this study was to evaluate the antimicrobial effectiveness of calcium hydroxide associated with a two conventional (anesthetic liquid and olive oil) and a new vehicle (Triethanolamine). <strong>Material and methods:</strong> Initially, microorganisms were collected from four upper incisors presenting unsatisfactory root canal treatments and persistent apical periodontitis from the same patient using sterile absorbent paper cones placed inside the root canal following initial access and root filling removal. Next, they were

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Estrela, Carlos, Cyntia R. A. Estrela, Daniel de Almeida Decurcio, Julio Almeida Silva, and Lili Luschke Bammann. "Antimicrobial potential of ozone in an ultrasonic cleaning system against Staphylococcus aureus." Brazilian Dental Journal 17, no. 2 (2006): 134–38. http://dx.doi.org/10.1590/s0103-64402006000200010.

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The aim of this study was to evaluate the antimicrobial potential of ozone applied to 3 different solutions in an ultrasonic cleaning system against Staphylococcus aureus. A total of 120 mL of S. aureus were mixed in 6 L of the experimental solutions (sterilie distilled water, vinegar and sterile distilled water + Endozime AWpluz) used in a ultrasonic cleaning system (UCS). Ozone was produced by an electric discharge through a current of oxygen and bubbling with flow rate at 7g/h ozone (1.2%) into the microbial suspensions. Ten mL of each experimental suspension were collected and 5 fold dilut

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Geethashri, A., KJ Palaksha, B. Mohana Kumar, KR Sridhar, Ganesh Sanjeev, and A. Veena Shetty. "EVALUATION OF ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF ELECTRON BEAM IRRADIATED ENDODONTIC SEALER." Journal of Health and Allied Sciences NU 04, no. 04 (2014): 076–80. http://dx.doi.org/10.1055/s-0040-1703837.

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Abstract Background: The persistent pathogenic microorganisms in root canal system even after chemo-mechanical preparations cause endodontic infection and failure of the treatment. Thus the filling material, in addition to its good sealing ability, should offer long term antimicrobial effect and be non-toxic to cells and dentin. Zinc Oxide Eugenol (ZOE) is the most commonly used root canal sealer in endodontics. Electron beam (e-beam) is an ionizing radiation and known to cause physiochemical and biological changes. The aim of this study was to evaluate the effect of e-beam irradiation on bioa

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Virote, Bárbara do Carmo Rodrigues, Daniel Vitor Martimiano, Sarah Lacerda Fabem, Marcelo Stefanini Tanaka, Letycia Andrade Locha, and Luis David Solis Murgas. "Use of ozone in the culture medium of zebrafish (Danio rerio) embryos." Acta Veterinaria Brasilica 16, no. 3 (2022): 287–93. http://dx.doi.org/10.21708/avb.2022.16.3.10986.

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In this study, we sought to demonstrate the toxicity of different concentrations of ozonated water in zebrafish embryos up to 120 hours postfertilization (hpf ) and their antimicrobial activity advantages. For the test, we placed 40 embryos per treatment in Petri dishes containing 30 ml of solution to be tested. The ozone concentrations used were calculated from an initial concentration of 72 μg/ml using the O&L 1.5 RM ozone generator (Ozone & Life, Brazil). Five serial dilutions 1:1 was performed in egg water to produce the ozone treatments. We also analyzed a treatment with 30 ml of

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Karobari, Mohmed Isaqali, Abdul Habeeb Adil, Ali A. Assiry, et al. "Herbal Medications in Endodontics and Its Application—A Review of Literature." Materials 15, no. 9 (2022): 3111. http://dx.doi.org/10.3390/ma15093111.

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Herbal products are gaining popularity in dental and medical practice nowadays due to their biocompatibility, higher antimicrobial activity, antioxidant and anti-inflammatory properties. Herbal medicine has experienced rapid growth in recent years due to its beneficial properties, ease of availability, and lack of side effects. As pathogenic bacteria become more resistant to antibiotics and chemotherapeutic agents, researchers are becoming more interested in alternative products and treatment choices for oral diseases. As a result, natural phytochemicals separated from plants and utilized in t

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Karobari, Mohmed Isaqali, Abdul Habeeb Adil, Ali A. Assiry, et al. "Herbal Medications in Endodontics and Its Application—A Review of Literature." Materials 15, no. 9 (2022): 3111. http://dx.doi.org/10.3390/ma15093111.

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Herbal products are gaining popularity in dental and medical practice nowadays due to their biocompatibility, higher antimicrobial activity, antioxidant and anti-inflammatory properties. Herbal medicine has experienced rapid growth in recent years due to its beneficial properties, ease of availability, and lack of side effects. As pathogenic bacteria become more resistant to antibiotics and chemotherapeutic agents, researchers are becoming more interested in alternative products and treatment choices for oral diseases. As a result, natural phytochemicals separated from plants and utilized in t

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Munaga, Swapna, Kiran R. Halkai, Abdul Kader Al Jarrah, Rajkiran Chitumalla, Rahul Halkai, and Sheeba Khan. "ROLE OF HERBAL EXTRACTS IN ROOT CANAL DISINFECTION AND REMOVAL OF SMEAR LAYER: A REVIEW." Journal of Chitwan Medical College 12, no. 2 (2022): 130–37. http://dx.doi.org/10.54530/jcmc.1118.

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Background: The success of endodontic treatment depends on the complete debridement and disinfection of canal space. Various chemicals have been used for canal disinfection. However, to overcome the adverse effects, toxicity issues, and microbial resistance of most conventional canal disinfectants, alternative agents are needed. Many herbal products have been studied and recommended for canal disinfection. This article aimed to review the role of herbal extracts in canal disinfection as an irrigant, intracanal medicament, and their efficacy in smear layer removal. Results: Studies were i

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Miglani, Sanjay, and Nobuyuki Tani-Ishii. "Biosynthesized selenium nanoparticles: characterization, antimicrobial, and antibiofilm activity against Enterococcus faecalis." PeerJ 9 (June 30, 2021): e11653. http://dx.doi.org/10.7717/peerj.11653.

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Background Control over microbial growth is a crucial factor in determining the success of endodontic therapy. Enterococcus faecalis is the most resistant biofilm-forming species leading to endodontic failure. Hence, the current researches are directed towards discovering materials with superior disinfection properties and lesser cytotoxicity. This study aimed to synthesize and characterize biogenically produced Selenium Nanoparticles, and to evaluate the antimicrobial and antibiofilm efficacy, against Enterococcus Faecalis, for the following test groups: Group I: Distilled water (control), Gr

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Chandani, Desai, and Desai Siddharth. "Silver Nanoparticles in Dental Cure Scenario and Confronts." International Journal of Trend in Scientific Research and Development 2, no. 2 (2018): 64–69. https://doi.org/10.31142/ijtsrd8319.

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Nanosilver and other forms of silver are widely used nowadays for their antibacterial activity. The different forms of silver, including silver salts, silver oxides and silver materials appearing as silver wires, silver nanopartilces AgNP and others, which are used in consumer and medical products, may have different physic chemical properties such as distinct solubility and surface to volume ratio, which all may affect their fate and biological activity. AgNPs display different applications in the field of dentistry owing to their antimicrobial effect. Various evidences has been found for sev

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Hashim, Nada Tawfig, Rasha Babiker, Shahistha Parveen Dasnadi, et al. "The Impact of Ozone on Periodontal Cell Line Viability and Function." Current Issues in Molecular Biology 47, no. 2 (2025): 72. https://doi.org/10.3390/cimb47020072.

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Periodontal diseases, including gingivitis and periodontitis, are chronic inflammatory conditions of the teeth’ supporting structures that can lead to progressive tissue destruction and loss if left untreated. Basic treatments like scaling and root planing, alone or combined with antimicrobial agents, are the standard of care. However, with the increasing prevalence of antibiotic resistance and the need for new ideas in therapy, adjunctive treatments like ozone therapy have gained attention. Ozone (O3), a triatomic oxygen molecule, is used because of its strong antimicrobial, anti-inflammatory

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Lenart-Boroń, Anna, Klaudia Stankiewicz, Klaudia Bulanda, et al. "In Vitro Antibacterial Activity of Ozonated Olive Oil against Bacteria of Various Antimicrobial Resistance Profiles Isolated from Wounds of Companion Animals." International Journal of Molecular Sciences 25, no. 6 (2024): 3557. http://dx.doi.org/10.3390/ijms25063557.

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Frequent colonization and bacterial infection of skin wounds in small animals prevent or impair their healing. However, the broadly applied antimicrobial therapy of wounds is not always necessary and promotes the spread of bacterial resistance. Thus, alternatives to antimicrobial therapy, including preventive measures in the form of wound dressings with antibiotic properties, should be searched for. The aim of this study was to develop a new, efficient, cost-effective and non-toxic formulation with antimicrobial properties to serve as an alternative to antibiotic administration in wound-healin

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Hayran, Yeliz, Sule Tugba Deniz, and Ali Aydın. "Antimicrobial Activity of Ozone against Pathogenic Oral Microorganisms on Different Denture Base Resins." Ozone: Science & Engineering 42, no. 1 (2019): 43–53. http://dx.doi.org/10.1080/01919512.2019.1626215.

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Ismail, Hira, Anjani Kumar Pathak, Nand Lal, and Mohd Aamir Khan. "OZONE A NOVEL INTERVENTION IN PERIODONTAL THERAPY - AN OVERVIEW." International Journal of Advanced Research 11, no. 12 (2023): 343–48. http://dx.doi.org/10.21474/ijar01/17993.

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Ozone has antimicrobial, immuno-stimulatory, anti-hypoxic, bioenergetic, and biosynthetic properties. It is inexpensive, minimally invasive and lacks adverse effects. It is a powerful tool for treating bacterial, fungal, and viral infections, as well as age-related macular degeneration, ischemic disorders, ocular disorders, orthopaedic diseases, haematological diseases, neurodegenerative diseases, pulmonary diseases, renal diseases, dermatological diseases and periodontal diseases. The use of ozone is well indicated in all stages of gingival and periodontal diseases because of its beneficial b

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Dorterler, Ozgul C., Berre Akgun, Mehlika Alper, and Fatma Ayhan. "Improving Antimicrobial Properties of GelMA Biocomposite Hydrogels for Regenerative Endodontic Treatment." Polymers 16, no. 12 (2024): 1675. http://dx.doi.org/10.3390/polym16121675.

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Regenerative endodontics is a developing field involving the restoration of tooth structure and re-vitality of necrotic pulp. One of the most critical clinical considerations for regenerative endodontic procedures is the disinfection of the root canal system, since infection interferes with regeneration, repair, and stem cell activity. In this study, we aimed to provide the synthesis of injectable biopolymeric tissue scaffolds that can be used in routine clinical and regenerative endodontic treatment procedures using Gelatin methacryloyl (GelMA), and to test the antimicrobial efficacy of Gelat

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Ugazio, Elena, Vivian Tullio, Arianna Binello, Silvia Tagliapietra, and Franco Dosio. "Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques." Molecules 25, no. 2 (2020): 334. http://dx.doi.org/10.3390/molecules25020334.

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The search for a wide spectrum of antimicrobial agents that can avoid resistance while maintaining reasonable side effects has led to ozonated oils experiencing an increase in scientific interest and clinical applications. The treatment of vegetable oils with ozone leads to the creation of a reservoir of ozone that slowly releases into the skin thanks to the fact that ozone can be held as ozonides of unsaturated fatty acids. Interest in the use of ozonated oils has meant that several ozonated-vegetable-oil-containing products have been commercialized as cosmetic and pharmaceutical agents, and

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Lačević, Amela, Edina Vranić, and Irfan Zulić. "Clinical application of calcium hydroxide in dental pathology and endodontics." Bosnian Journal of Basic Medical Sciences 3, no. 4 (2003): 26–29. http://dx.doi.org/10.17305/bjbms.2003.3488.

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Calcium hydroxide has a hard tissue inducing effect. It is a powder, that can be mixed with a physiological saline to a paste. The paste is highly alkaline with a pH 12.5 and its application to the pulp results in necrosis of the part of coronal pulp tissue shows no or only a milled inflammatory reaction. Analyzing the pH and the concentration of calcium ions in the periapical area, it is obvious that at least 2 weeks are necessary for calcium hydroxide bactericide activity. Calcium hydroxide retains its anti-bacterial properties for about two months when placed under a restoration, after whic

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Çınar Acar, Berat. "Evaluation of ozone effectiveness against Gram-positive and Gram-negative pathogens using different methods." Mustafa Kemal Üniversitesi Tarım Bilimleri Dergisi 29, no. 2 (2024): 606–21. http://dx.doi.org/10.37908/mkutbd.1437244.

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Ozone attracts great attention due to its strong oxidative properties, antimicrobial activity, easy applicability, operating costs almost negligible, lack of chemicals in its use, highly effective and environmentally friendly application. In this study, two Gram (+) and two Gram (-) bacterial cultures, known as pathogens, were used to examine the effect of ozone gas on the growth of bacterial cultures. The samples were treated with ozone at different flow rates (4, 5, and 6 mg/L) and durations (1, 5, 10, 15, and 20 min) with different application parameters (pathogen bacteria, distilled water,

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Mahmoudvand, Hossein, Majid Fasihi Harandi, Massumeh Niazi, Abdolreza Rouientan, Fazel Mohammadi-Moghadam, and Ebrahim Saedi Dezaki. "The High Potential of Ozone Gas to Inactivate Echinococcus granulosus Protoscoleces During Hydatid Cyst Surgery." Infectious Disorders - Drug Targets 20, no. 5 (2020): 708–12. http://dx.doi.org/10.2174/1871526519666190924160925.

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Background: In medicine, ozone therapy is effectively used in a broad spectrum of diseases. Reviews have shown that ozone gas demonstrates potent antimicrobial effects against a wide range of pathogenic microorganisms, such as oral bacteria, fungi, viruses, and parasite even in resistant strains. The present investigation was designed to assess the protoscolicidal effects of ozone gas on hydatid cysts protoscoleces in vitro and in vivo. Methods: Hydatid cyst protoscoleces were acquired from sheep livers that were slaughtered at Kerman slaughterhouse, Iran. The viability of protoscoleces was as

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Lisa, Elena Lacramioara, Geta Carac, Irina Teodora Lupu, Andrei Iliescu, and Alexandru Andrei Iliescu. "Chemical Interactions among Some Antimicrobial Solutions and Chelating Agents Used in Endodontics for Irrigation of Infected Root Canals." Revista de Chimie 68, no. 7 (2017): 1490–95. http://dx.doi.org/10.37358/rc.17.7.5702.

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The root canal irrigants are of utmost importance in the soft tissue dissolving, the removal of microorganisms, hard-tissue debris, and smear layer. This study sets forth to investigate the stability and synergic interactions of different systems with various combinations among antimicrobial substances and chelating agents, frequently used in endodontics for the irrigation of the infected root canals through electrochemical evaluation, physicochemical and spectrophotometric analysis. The pharmaceutical products indicated as the antiseptic solutions (sodium hypochlorite - NaOCl, chlorhexidine -

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