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Dissertations / Theses on the topic 'P2X7'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Boumechache, Miyyada. "Structural and functional interaction between P2X4, P2X7 and Pannexin-1." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608656.

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2

O'Brien-Brown, James. "Novel P2X7 Receptor Ligands." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21280.

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The P2X7 receptor (P2X7R) is a purinergic receptor that plays a central role in the inflammatory response. Activation of the P2X7R releases pro-inflammatory cytokines such as interleukin 1β (IL-1β), which have been shown to underlie the pathogenesis of a number of neurodegenerative disorders. Consequently, the development of a CNS penetrant P2X7R antagonist is considered a promising target for the inhibition of neurodegenerative diseases. A series of P2X7R antagonists were synthesised to investigate which structural features of the hydrophobic moiety dictated binding site selectivity (orthost

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3

FURINI, Federica. "P2X7 receptor (P2X7R) in Systemic Lupus Erythematosus (SLE). Exploring a novel pathogenetic pathway." Doctoral thesis, Università degli studi di Ferrara, 2019. http://hdl.handle.net/11392/2487988.

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Introduzione. P2X7R è un recettore extracellulare ATP-dipendente coinvolto in processi infiammatori e autoimmuni che agiscono principalmente attraverso l'attivazione dell'inflammasoma NLRP3 e il rilascio di IL-1β, ed anche tramite processi implicati nella regolazione della proliferazione dei linfociti e nell'apoptosi cellulare. Diverse osservazioni da modelli animali e studi su paziente evidenziano un possibile collegamento tra l'asse P2X7R-NLRP3 e la patogenesi del Lupus Eritematoso Sistemico (SLE). L'asse inflammasoma-P2X7R oltre alla produzione diretta di IL-1b e IL-18, è coinvolto indirett

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4

Kunert, Christin. "Funktioneller Nachweis des purinergen Rezeptors P2X7 an den neuralen Progenitorzellen der murinen Subventrikularzone." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-130838.

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Neurodegenerative Erkrankungen sind wegen steigender Prävalenz ein zunehmendes Problem in Industrieländern. In diversen Studien wurde bereits ein Zusammenhang zwischen neurodegenerativen Vorgängen und purinerger Signalübertragung aufgezeigt. Insbesondere die Rezeptoruntereinheit P2X7R ist durch seine apoptotische Wirkung bei verschiedenen Krankheiten involviert. Im Rahmen dieser Arbeit wurde die funktionelle Präsenz des P2X7R an neuralen Progenitorzellen untersucht, die von der Subventrikularzone (SVZ) der Maus isoliert wurden. Mittels Calcium-Imaging wurde die intrazelluläre Ca2+-Konzentratio

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5

Weinhold, Karina. "Molekulare und biochemische Charakterisierung der purinergen Rezeptoren P2X4 und P2X7 im Alveolarepithel der Lunge." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-62141.

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Gegenstand der vorliegenden Arbeit sind die purinergen Rezeptoren P2X4R und P2X7R. Die P2XR werden durch ATP aktiviert und stellen unselektive Kationenkanäle dar, die auch für Ca2+ durchlässig sind. Beiden P2XR-Subtypen werden in den Alveolarepithel Typ I (AT I)-Zellen der Lunge exprimiert und aufgrund ihrer Kanalaktivitäten in Zusammenhang mit der alveolären Flüssigkeitshomöostase gebracht. Bei bisherigen Untersuchungen wurde jedoch die mögliche Assoziation und Modulation der P2XR durch Mikrodomänen der Zellmembran außer Acht gelassen. Ein Modell von Garcia-Marcos zeigt, dass P2X7R in Zellen

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6

Prudic, Kirsten [Verfasser]. "Charakterisierung koexprimierter humaner purinerger P2X4- und P2X7-Rezeptoren in Xenopus Laevis Oozyten / Kirsten Prudic." Halle, 2017. http://d-nb.info/1130148157/34.

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7

Stevenson, Diane J. "P2X7, inflammation and gastrointestinal disease." Thesis, University of Nottingham, 2008. http://eprints.nottingham.ac.uk/28897/.

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The inflammatory bowel diseases, ulcerative colitis and Crohn's disease are characterised by spontaneously relapsing and remitting inflammation, associated with increased mucosal levels of the inflammatory cytokine, interleukin-1 (IL-1)β. IL-1β processing and release is mediated by ATP stimulation of the purine receptor, P2X7. P2X7 is a membrane ion channel highly expressed in immune cells. Signal transduction occurs via rapid cation exchange, plasma membrane depolarisation and increased intracellular calcium. Additionally, prolonged or repeated P2X7 stimulation leads to formation of a non-sel

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8

Hempel, Christoph. "Neue Modulatoren des P2X7-Rezeptors." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-161341.

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P2X7-Rezeptoren stellen Schlüsselmoleküle bei der Entstehung und Aufrechterhaltung proinflammatorischer Zustände, chronischer Schmerzen sowie der neuroglialen Kommunikation dar. Ihre Aktivität wird durch eine Vielzahl zellbiologischer Mechanismen beeinflusst. Dazu gehört die allosterische Modulation durch extrazelluläre niedermolekulare Stoffe. Die Entwicklung selektiver und potenter P2X7-Modulatoren ist darum Gegenstand intensiver Forschung. Bisher sind jedoch keine Pharmaka für die klinische Anwendung verfügbar. Die Untersuchung zugelassener pharmakologischer Substanzen in einem akademischen

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9

AMOROSO, Francesca Saveria. "P2X7 Receptor: Warburg effect revisited." Doctoral thesis, Università degli studi di Ferrara, 2012. http://hdl.handle.net/11392/2389273.

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Ability to adapt to conditions of limited nutrient supply is a key feature of all cells. This may require a complex re-organization of metabolic pathways to balance energy generation and production of biosynthetic intermediates. Several fast-growing cells overexpress the P2X7 receptor (P2X7R) for extracellular ATP. A peculiar feature of this receptor is that it allows growth in the absence of serum. We show here that transfection of P2X7R allows proliferation of HEK293 (HEK293-P2X7) cells not only in the absence of serum but also in low (4 mM) glucose and strongly increases lactate output comp

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10

SARTI, Alba Clara. "P2X7 expression modulates mitochondrial metabolism." Doctoral thesis, Università degli studi di Ferrara, 2016. http://hdl.handle.net/11392/2403380.

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L’espessione del recettore P2X7 modula il metabolismo mitocondriale. Il recettore P2X7 è principalmente conosciuto per la sua abilità nel causare morte cellular dovuta ad una prolunata attivazione data dall’ATP, tramite un aumento della permeabilizzazione della membrane plasmatica. Al contrario una brave attivazione causa una modificazioni della concentrazione intracellulare di cationi che si associa a differenti processi fisiologici come induzione della cascata infiammatoria, proliferazione e soppravivemza cellulare. Negli ultimi anni si è cercato di comprendere meglio i meccanismi trami

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11

Taylor, Simon Richard James. "The P2X7 receptor in immune cells." Thesis, Imperial College London, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508719.

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The P2X7 receptor is a cation channel activated by high concentrations of ATP. Its stimulation is pro-inflammatory, with activation resulting in the release of cytokines (notably IL-1β), changes in plasma membrane lipid distribution, and cell death. A central role for P2X7 in IL-1β secretion via the NALP3 inflammasome has been confirmed in gene-deficient mice generated by GlaxoSmithKline (GSK) and Pfizer. It is abundantly expressed on cells of the immune system and may play a role in the pathogenesis of autoimmune disease, notable systemic lupus erythematosus (SLE). Indeed, P2X7 has become an

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12

Gu, Baijun. "THE P2X7 RECEPTOR OF HUMAN LEUKOCYTES." Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/501.

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Lymphocytes from normal subjects and patients with B-chronic lymphocytic leukemia (B-CLL) show functional responses to extracellular ATP characteristic of the P2X7 receptor. These responses include opening of a cation selective channel/pore which allows entry of the fluorescent dye, ethidium+ and activation of a membrane metalloprotease which sheds the adhesion molecule L-selectin. In this thesis, the surface expression of P2X7 receptors was measured in normal leucocytes, platelets and B-CLL lymphocytes and compared with their functional responses. Monocytes showed 4-5 fold greater express

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13

Gu, Baijun. "THE P2X7 RECEPTOR OF HUMAN LEUKOCYTES." University of Sydney. Medicine, 2003. http://hdl.handle.net/2123/501.

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Lymphocytes from normal subjects and patients with B-chronic lymphocytic leukemia (B-CLL) show functional responses to extracellular ATP characteristic of the P2X7 receptor. These responses include opening of a cation selective channel/pore which allows entry of the fluorescent dye, ethidium+ and activation of a membrane metalloprotease which sheds the adhesion molecule L-selectin. In this thesis, the surface expression of P2X7 receptors was measured in normal leucocytes, platelets and B-CLL lymphocytes and compared with their functional responses. Monocytes showed 4-5 fold greater express

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14

Girotti, Priscila Azevedo. "Análise morfoquantitativa dos neurônios mioentéricos e submucosos imunorreativos aos receptores P2X2 e P2X7, ao óxido nítrico sintase (NOS), à calretinina, à calbindina e à colina acetil transferase (ChAT) do colo distal de ratos submetidos à desnutrição e à renutrição protéica." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-09102008-125826/.

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Este projeto, analisou a distribuição dos neurônios nos plexos mioentérico (PM) e submucoso (PS) imunorreativos aos receptores P2X2 (ir) e P2X7 (ir), calbindina (Calb-ir), calretinina (Calr-ir), colina acetil transferase (ChAT-ir) e ao óxido nítrico sintase (NOS-ir) do colo distal de ratos submetidos à desnutrição a renutrição protéica. Utilizaram-se colos distais de ratos nutridos (N42), desnutridos (D42) e renutridos (RN42). Os resultados do plexo PM, demonstraram que 100% dos neurônios Calb-ir, Calr-ir, ChAT-ir e NOS-ir, expressavam os receptores P2X2-ir e P2X7-ir nos três grupos. A densida

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15

Kopp, Robin [Verfasser], and Annette [Akademischer Betreuer] Nicke. "Analysis of P2X7 protein complexes in a P2X7-EGFP BAC transgenic mouse model / Robin Kopp ; Betreuer: Annette Nicke." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1231712279/34.

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16

Benzaquen, Jonathan. "Étude de l’impact de l’expression de variants d’épissage sur les fonctions biologiques de P2RX7 : rôle dans l’adénocarcinome broncho-pulmonaire humain." Electronic Thesis or Diss., Université Côte d'Azur, 2020. http://www.theses.fr/2020COAZ6049.

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Le cancer du poumon, découvert classiquement à un stade avancé et non opérable, est la première cause de décès par cancer. Les avancées en immunothérapie anti tumorale ont changé le pronostic de cette pathologie en positionnant cette approche comme un élément principal de la prise en charge à ce jour. Néanmoins la survie à cinq ans du cancer du poumon, tous stades confondus, reste inférieure à 20% et il est donc nécessaire de mieux comprendre sa physiopathologie afin d’identifier de nouvelles approches thérapeutiques. Mon laboratoire d’accueil a récemment montré que le récepteur purinergique P

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17

Hillman, Katherine Anne. "P2X7 in normal and cystic kidney development." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446590/.

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P2X7 is a unique member of the P2X family of membrane receptors for extracellular ATP. As well as being a non-selective cation channel, this membrane receptor is implicated in several biological functions, including cell death and proliferation. P2X7 expression, initially thought restricted to immune cells, also occurs in epithelial and other cell types. I hypothesised that P2X7 is functionally expressed in the renal tract, particularly in situations in which cell turnover is prominent. I have demonstrated expression of P2X7 in both mouse and human kidney. During mouse nephrogenesis P2X7 was d

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18

Jackson, Alexander Rodney. "Pharmacological Evaluation of Cyanoguanidine P2X7 Receptor Antagonists." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17186.

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ABSTRACT BACKGROUND AND AIMS: The P2X7 receptor (P2X7R) is an ATP-gated, non-selective cation channel highly expressed on monocytes, macrophages and microglia. Prolonged activation of the P2X7R by ATP leads to cytolytic pore formation and the release of inflammatory mediators including interleukin-1β and prostaglandin E2. Accumulating evidence suggests a role for the P2X7R in neuroinflammation and thus P2X7R antagonists might be useful in diseases including chronic pain, depression and Alzheimer’s disease. Both negative allosteric modulators of the P2X7R, such as the adamantyl benzamides, and

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19

Safya, Hanaa. "Modulation des activités du récepteur purinergique P2X7 au cours de l’activation des lymphocytes T." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T083/document.

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L’ATP extracellulaire, à travers l’activation du récepteur P2X7, joue un rôle important dans l’immunité inné comme signal de danger responsable de l’assemblage de l’inflammasome, de la migration des cellules immunitaires et de la mort cellulaire. Bien que le rôle de la voie ATP/P2X7 dans l’immunité adaptative reste sous-estimé, il a été rapporté que le récepteur P2X7 participe aux mécanismes de signalisation impliqués dans l’activation des lymphocytes T, leur prolifération et leur différentiation. Notre laboratoire a récemment montré que les lymphocytes T effecteurs (CD4+ ou CD8+) en fin de ré

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20

El, Ouaaliti Malika. "Study of the expression and the role of P2X4 and P2X7 receptors in polarized murine and human macrophages." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209377.

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Throughout this work, we looked at P2X coupled pathways in macrophages. We worked on three different models of macrophages in order to establish the best model to understand the role of P2X4 receptors in the inflammation. Our work also consisted of further characterizing P2X7 receptor dependent pathways in these models. <p>P2X4 and P2X7 receptors are ionotropic receptors which are expressed by a variety of immune cells including macrophages. Macrophages play a very important host defense function as they are major actors in the innate immune system and they can initiate the activation of the a

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21

Deplano, Simona. "Role of P2X7-mediated inflammasome activation in glomerulonephritis." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/17794.

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Glomerulonephritis is a major cause of kidney failure and current treatment is based on nonspecific immunosuppressive therapies. The purinergic P2X7 receptor (P2X7R) is usually not detectable in renal tissue. However, previous studies have demonstrated an increased glomerular P2X7R expression in animal models of glomerulonephritis. Furthermore, P2X7R knock-out mice have been shown to be significantly protected from antibody-mediated glomerulonephritis. P2X7R activation represents a fundamental step for the activation of the NLRP3 inflammasome which leads to the processing and release of IL-1β

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22

Leeson, Hannah Caitlin. "P2X7 Receptor Regulation of Hippocampal Neural Progenitor Cells." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/373045.

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Adult hippocampal neurogenesis plays an essential role in the formation and consolidation of new memories, spatial processing and some forms of learning. Identifying the molecular mechanisms that regulate hippocampal neural progenitor cells as they proliferate, differentiate, and are selected for either survival or cell death will provide a fundamental understanding of how this neurogenic niche coordinates these activities. Here, the roles of P2X7 receptors are examined for their influence over neural progenitor cell biology, particularly cell death, proliferation, and phagocytosis of apoptoti

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23

SCUSSEL, BERGAMIN Leticia. "Pathophysiology of the P2X7 receptor in the skeleton." Doctoral thesis, Università degli studi di Ferrara, 2021. http://hdl.handle.net/11392/2488315.

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The biological effects of ATP are mediated by purinergic receptors, and, among them, P2X7R exhibits unique molecular and functional features. P2X7R is involved in a series of skeletal physiological activities, and it has also been associated in some bone and joint diseases. Thereby, P2X7R can be considered a potential drug target. The work of this thesis is part of a broader project aimed at identifying new molecular targets for the development of innovative therapeutic strategies to be used for the treatment of pathologies that affect bone and cartilage, and for slowing the physiological dege

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24

Bianco, F. "The role of P2X7 receptor in glial cells." Doctoral thesis, Università degli Studi di Milano, 2007. http://hdl.handle.net/2434/63133.

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Summary of thesis The aim of this study was to study the functional consequences of the ATP mediated communication between astrocytes and microglia, with particular emphasis on the functional consequences related to the activation of purinergic receptor P2X7 on microglial cells. The results obtained indicate that: 1. that the LPS-induced reduction of functional P2X7 receptor in embryonic microglia may mediate the cell cycle modifications observed upon exposure to the endotoxin. 2. the release of at least a fraction of IL 1-beta from microglia takes place, upon ATP stimulation, through the shed

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25

Huang, Szu-Wei. "The role of the purinergic P2X7 receptor in small intestinal inflammation." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-the-purinergic-p2x7-receptor-in-small-intestinal-inflammation(e96a14cf-de69-47ac-bcf9-7730d9006364).html.

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The purinergic P2X7 receptor (P2X7R), an adenosine triphosphate (ATP)-gated receptor, is widely distributed in a variety of cell types such as neuron cells, immune cells and epithelial cells. P2X7R on cells senses extracellular ATP released from dying cells which then acts as a danger signal and initiates inflammation. Activation of P2X7R results in various downstream events, including Ca2+ influx, nonselective membrane pore formation, cell death, assembly of the inflammasome, and killing of intracellular pathogens. Epithelial cells in the gut also express P2X7R and act as a sentinel that prot

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26

Robinson, Lucy Elizabeth. "Regulation of the P2X7 receptor by plasma membrane cholesterol." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709439.

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27

Chavda, S. "P2X7 receptor modulation of visual responses in the retina." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1464069/.

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Adenosine 5’ triphosphate (ATP)-gated P2X7 receptors (P2X7Rs) are known to act as conduits for photoreceptor and retinal ganglion cell (RGC) damage, consequences of various neurodegenerative conditions within the visual pathway. Growing evidence supports the notion that P2X7Rs and associated inflammatory mediators may coordinate microglia, the resident immune cells of the central nervous system (CNS), to play a genuine role in modulating neurotransmission. This study aimed to characterise the role of P2X7Rs in modulating outer and inner retinal function within the rod-mediated pathway, and in

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28

Gonnord, Pauline. "Etude des relations structure-fonction du récepteur purinergique P2X7." Paris 11, 2008. http://www.theses.fr/2008PA11T024.

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Callegari, Maria Giulia <1978&gt. "Ruolo del recettore P2X7 nella sopravvivenza e morte cellulare." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/259/1/TESI_Maria_Giulia_Callegari.pdf.

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Callegari, Maria Giulia <1978&gt. "Ruolo del recettore P2X7 nella sopravvivenza e morte cellulare." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/259/.

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31

Besnard, Aurore. "Rôle de la signalisation purinergique au cours de la régénération du foie chez la souris : étude des récepteurs P2X4 et P2X7." Paris 6, 2013. http://www.theses.fr/2013PA066054.

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Objectif : La régénération hépatique est un processus complexe qui met en jeu de nombreux signaux régulateurs endocrines, paracrines, autocrines et nerveux. L’ATP extracellulaire et plus généralement la signalisation purinergique, ont été décrits comme ayant un rôle dans la survie et la prolifération cellulaires ainsi que dans les processus inflammatoires et sécrétoires. Le laboratoire a rapporté antérieurement que l’ATP extracellulaire contribuait à la régénération du foie chez le rat. L’objectif de ce travail était d’étudier le rôle des récepteurs ionotropiques P2X4 et P2X7 au cours de la ré

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Teodoro, Luis Henrique de Souza. "Caracterização funcional do receptor P2X7 na glândula pineal de rato." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-28032014-093312/.

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A sinalização purinérgica tem sido demonstrada como um um importante modulador dediversos processos fisiológicos e fisiopatológicos. Dentre os receptores purinérgicos, o receptor P2X7 distingui-se por requerir altas concentrações de ATP em sua ativação. As demonstrações prévias de que a glândula pineal responde a diferentes estímulos purinérgicose a altas concentrações de ATP sugere um papel para os receptores P2X7 nesta glândula, embora sua expressão e função não estivesse estabelecida. O objetivo deste trabalho, portanto, foi caracterizar funcionalmente o receptor P2X7 na glândula pineal de

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33

Teixeira, Juliana Maia 1984. "Involvement of P2X3 and P2X7 purinergic receptors in inflammatory articular hyperalgesia in the knee joint of rats and the study of the peripheral mechanisms involved = Participação dos receptores purinérgicos P2X3 e P2X7 na hiperalgesia inflamatória articular em joelho de ratos e o estudo dos mecanismos periféricos envolvidos." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314054.

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Orientador: Cláudia Herrera Tambeli<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-25T14:36:32Z (GMT). No. of bitstreams: 1 Teixeira_JulianaMaia_D.pdf: 23889164 bytes, checksum: c8f281ea2cb5d4c68fb62ac535731385 (MD5) Previous issue date: 2014<br>Resumo: A osteoartrite (OA) é uma doença degenerativa e progressiva, caracterizada pela degradação da cartilagem que reveste as extremidades ósseas e inflamação da membrana sinovial, causando incapacidade física, inchaço articular e dor. Embora o alívio da dor severa seja o princi

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Xu, Xing Jian. "Characterization of the functional properties of P2X7 receptor splice variants." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610293.

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35

Fischer, Wolfgang, Heike Franke, Ute Krügel, et al. "Critical evaluation of P2X7 receptor antagonists in selected seizure models." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206115.

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The ATP-gated P2X7 receptor (P2X7R) is a non-selective cation channel which senses high extracellular ATP concentrations and has been suggested as a target for the treatment of neuroinflammation and neurodegenerative diseases. The use of P2X7R antagonists may therefore be a viable approach for treating CNS pathologies, including epileptic disorders. Recent studies showed anticonvulsant potential of P2X7R antagonists in certain animal models. To extend this work, we tested three CNS-permeable P2X7R blocker (Brilliant Blue G, AFC-5128, JNJ-47965567) and a natural compound derivative (tanshinone

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Gartland, Alison. "The role of the P2X7 receptor in bone cell formation." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343968.

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37

Caseley, Emily Alice. "Structural basis for ligand-receptor interactions at the P2X7 receptor." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/15858/.

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P2X7 receptors (P2X7Rs) belong to the P2X receptor family of ligand-gated ion channels activated by extracellular ATP. The human P2X7R (hP2X7R) is implicated in numerous debilitating disease conditions and thus represents a promising therapeutic target. However, P2X7R structure-function relationships remain less well understood. The study presented in this thesis used electrophysiology in conjunction with structural modelling, molecular docking and site-directed mutagenesis to better understand the structural basis for ligand-receptor interactions at P2X7Rs and used such structural information

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38

Jelassi, Bilel. "Implication des récepteurs P2X7 dans l'invasivité des cellules cancéreuses humaines." Thesis, Tours, 2013. http://www.theses.fr/2013TOUR3318/document.

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Le récepteur-canal P2X7 est fortement exprimé et est fonctionnel dans la lignée de cellules cancéreuses mammaires humaines hautement invasives MDA-MB-435s. L’activation de P2X7 par l’ATP extracellulaire est responsable de l'émission des prolongements cellulaires et l'augmentation de la migration cellulaire. En outre, l’activation de P2X7 augmente l’invasion cellulaire à travers la matrice extracellulaire et fait intervenir la libération de forme mature de cathepsines à cystéine dans le milieu extracellulaire. L’inhibition pharmacologique de P2X7 diminue l’invasivité des cellules cancéreuses da

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Soares, Rafael Ferreira. "Estudos in silico do comportamento dinâmico do receptor P2x7 humano." reponame:Repositório Institucional da FIOCRUZ, 2015. https://www.arca.fiocruz.br/handle/icict/13939.

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Made available in DSpace on 2016-04-20T12:39:27Z (GMT). No. of bitstreams: 2 rafael_soares_ioc_mest_2015.pdf: 5479188 bytes, checksum: f6ce23593dd41a10564934ddfa4bd278 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2015<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil<br>O receptor P2X7, contido na família de receptores P2, é um receptor inotrópico purinérgico, cátion seletivo, ativado por nucleotídeos (ATP). Esses receptores são expressos em células do sistema nervoso central, periférico e células da linhagem

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CAPECE, Marina. "Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7." Doctoral thesis, Università degli studi di Ferrara, 2016. http://hdl.handle.net/11392/2403471.

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Il recettore per l’ATP, P2X7 (P2X7R) riveste un ruolo fondamentale nell’infiammazione e nell’immunità, ma la sua funzione in ambito tumorale non è ancora stata completamente stabilita. In questo studio abbiamo analizzato la crescita e la disseminazione tumorale di cellule murine di melanoma (B16) o colon carcinoma (CT26) in modelli in vivo deleti del gene per il recettore P2X7 (P2X7R-KO). La crescita della massa tumorale sottocute è stata valutata tramite la misurazione manuale con il calibro, mentre la trasfezione delle cellule con una luciferasi intracitosolica ci ha permesso di monitorare l

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Mendes, Cristina Eusébio. "Estudo das células gliais entéricas imunorreativas aos receptores P2x2 e P2x7 do íleo de ratos submetidos à isquemia e reperfusão intestinal." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-13032014-173541/.

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A resposta do sistema nervoso para diversas lesões acarreta a ativação das células gliais entéricas. Este trabalho tem como objetivo analisar o efeito da isquemia e reperfusão intestinal (I/R-i) sobre as células gliais entéricas, neurônios e receptores P2X2 e P2X7. Foram analisados o íleo de ratos Controle, Sham e I/R-i com 0 hora, 24 horas e 14 dias de reperfusão. Foram realizadas dupla marcação dos receptores P2X2 e P2X7 com Hu e S100, densidade, área do perfil e marcação de proliferação celular. Os resultados mostraram dupla marcação de células gliais entéricas e neurônios com os receptores

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Mellouk, Amine. "Rôle des récepteurs purinergiques P2X7 et d'apoptose Fas dans l'homéostasie des lymphocytes T et le développement des maladies auto-immunes." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS221.

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Mon étude a porté sur le rôle du récepteur purinergique P2X7 (P2X7R) dans les processus physiopathologiques impliqués dans le développement des maladies auto-immunes de type lupique. Les souris MRL/lpr, déficientes en récepteurs d’apoptose Fas (mutation lpr), développent spontanément ces pathologies suite à l’accumulation lymphocytes T pathogéniques CD4−CD8− (DN) B220+ dans les organes lymphoïdes secondaires. Nous avons observé que ces lymphocytes ont également un déficit d’expression en P2X7R à leur surface. Cela nous a amené à postuler que P2X7R pourrait jouer un rôle clé dans l’homéostasie

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Alberto, Anael Viana Pinto. "Caracterização dos receptores P2 em eosinófilos de ratos e do poro associado ao receptor P2X7." Instituto Oswaldo Cruz, 2012. https://www.arca.fiocruz.br/handle/icict/6938.

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Submitted by Alessandra Portugal (alessandradf@ioc.fiocruz.br) on 2013-09-20T15:33:03Z No. of bitstreams: 1 Anael Viana Pinto Alberto.pdf: 4150812 bytes, checksum: 9ce0a5d780533302dcc603ae65f510fe (MD5)<br>Made available in DSpace on 2013-09-20T15:33:03Z (GMT). No. of bitstreams: 1 Anael Viana Pinto Alberto.pdf: 4150812 bytes, checksum: 9ce0a5d780533302dcc603ae65f510fe (MD5) Previous issue date: 2012-10-31<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil<br>ATP e outros nucleotídeos são liberados para o meio extracelular por vias reguladas ou pela perda da in

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Hansen, Thomas Sommer. "Targeting inflammation and dysregulated redox signalling via new pathways in cardiovascular disease." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24321.

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Background: The role of dysregulated redox signalling and inflammation in driving many cardiovascular disease processes is firmly established. However, therapeutic targeting of redox and inflammatory pathways has been largely unsuccessful to date and there is great scope for improvement with novel therapies. The initial focus of this Thesis was to investigate the role of FXYD1, a protein with known cardiac redox-modulating effects, on pulmonary hypertension (PH). I then focused on the inflammatory pathways in pulmonary hypertension, specifically the NLRP3 inflammasome, using a novel antagonist

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Alqallaf, Sayed Mahmood. "Characterisation of P2X7 receptors in human osteoblasts and modulation by oestrogen." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/55732/.

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Purinergic P2X7 receptors are ligand-gated ion channels characterized by the formation of a membrane pore upon continuous activation. This receptor has been shown to be expressed and functional in osteoclasts. P2X7 receptor knockout mice studies suggested that this receptor has a role in bone formation. The aim of this project was to characterise the expression and function of P2X7 receptors in human osteoblasts and to investigate the modulation of P2X7 receptor expression and function by oestrogen and glucocorticoids. Reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotti

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Lappin, Sarah Crawford. "Biophysical and pharmacological characterisation of recombinant and native rat P2X7 receptors." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/4360.

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P2X7 receptors exhibit a mainly non-neuronal localisation on immune and glial cells and primarily function as non-selective cation channels. After prolonged or repeated exposure to agonist, functional and cellular changes occur: the formation of a large diameter pore, cell lysis and the release of mature, biologically active interleukin-1β (IL-1β) a potent inflammatory cytokine. It is this repertoire of functions, along with its localisation that underlies the hypothesis for its involvement in pain processing. The biophysics and pharmacology of rat P2X7 receptors were investigated using stable

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Palaskali, Sascha [Verfasser]. "Charakterisierung von Cyclothiazid als Antagonist von humanen P2X7-Rezeptoren / Sascha Palaskali." Ulm : Universität Ulm. Medizinische Fakultät, 2011. http://d-nb.info/1018024883/34.

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Medhurst, Stephen John. "Investigating the association between P2X7 receptors, microglia and the actions of morphine." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5539.

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P2X7 receptors belong to a family of membrane bound ion channels which are activated by extracellular ATP, resulting in the opening of a non-selective cation channel. After prolonged or repeated exposure to agonist, functional and cellular changes can occur, including the formation of a large pore, cell lysis and the release of mature, biologically active interleukin-1β. It is this diversity of functions that underlies the significance of this receptor in pain processing. P2X7 receptors are expressed on microglia, which when activated, release a host of mediators which contribute to central se

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Santos, Junior André Avelino dos. "Papel do receptor P2X7 em modelo murino de infecção por Mycobacterium tuberculosis." Pontifícia Universidade Católica do Rio Grande do Sul, 2012. http://hdl.handle.net/10923/1395.

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Made available in DSpace on 2013-08-07T18:41:56Z (GMT). No. of bitstreams: 1 000439217-Texto+Completo-0.pdf: 703680 bytes, checksum: 20bc10f7a801c99b27dde05bf2a6dc66 (MD5) Previous issue date: 2012<br>Tuberculosis (TB) remains a leading cause of death worldwide, due to the great adaptability of the bacillus, which can survive in various conditions inside and outside the human host. Previous studies showed evidence that polymorphisms in P2X7 receptor are e associated with increased risk of TB. The present study aimed to analyze the role of purinergic P2X7 receptor in M. tuberculosis infection

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SALARO, ERICA. "Involvement of the P2X7-NLRP3 axisi in Leukemic Cell Proliferation and Death." Doctoral thesis, Università degli studi di Ferrara, 2016. http://hdl.handle.net/11392/2403212.

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Lymphocyte growth and differentiation are modulated by extracellular nucleotides and P2 receptors. We previously showed that the P2X7 receptor (P2X7R or P2RX7) is overexpressed in circulating lymphocytes from chronic lymphocytic leukemia (CLL) patients. In the present study we investigated the P2X7R/NLRP3 inflammasome axis in lymphocytes from a cohort of 23 CLL patients. P2X7R was overexpressed and correlated with chromosome 12 trisomy in CLL patients. ASC mRNA and protein were also overexpressed. On the contrary, NLRP3 were dramatically down-modulated in CLL lymphocytes relative t

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