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Dissertations / Theses on the topic 'P450c17'

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Published: 4 June 2021
Last updated: 27 April 2022

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1

Viana, Diego Carvalho. "Sazonalidade reprodutiva em machos de tartaruga (Kinosternon scorpioides) de vida livre no Nordeste brasileiro evidenciado por imunolocalização de enzimas esteroidogênicas no testículo e epidídimo." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-11052016-170811/.

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No Estado do Maranhão, na região da Baixada Maranhense, presenta na fauna silvestre o réptil Kinosternon scorpioides, um quelônio de água doce popularmente conhecido como jurará e que possui valor social, econômico e ambiental para os ribeirinhos da cidade de São Bento. Este estudo contempla suas características biológicas reprodutivas baseadas em seu ambiente natural, com o intuito de permitir a preservação e o estabelecimento de planos de manejo reprodutivo e de uso sustentável da espécie. Recentemente poucos estudos em todo o mundo tratam sobre os aspectos do ciclo reprodutivo de tartarugas
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2

Courtemanche, Jean. "Caractérisation des cytochromes P450c11 et P450c18 chez le hamster." Mémoire, Université de Sherbrooke, 1995. http://hdl.handle.net/11143/12059.

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Lors de l'étude du P450c18 de hamsters sous-diète faible en sodium, une analyse par buvardage de type Northern, à partir de surrénale, a permis de révéler trois bandes à 2 kb, 2.3 kb et 3.4 kb respectivement à l'aide d'une sonde spécifique au P450c18. Ces trois formes d'ADNc ont été recherchées dans une banque d'ADNc de surrénale de hamster. Deux clones différents ont été isolés codant pour le P450c18 (clone 18 et clone 5) et deux codant pour le P450c11 (clone 43 et clone ?1). La comparaison de la région codante du P450c11 clone ?1 avec le P450c18 clone 18 montre une homologie de 90% entre les
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3

Gentil, Michaela [Verfasser]. "Wiedereinsetzen der Steroidbiosynthese nach Downregulation der Hodenfunktion beim Rüden : Expression von StAR-Protein, P450scc und P450c17 / Michaela Gentil." Gießen : Universitätsbibliothek, 2012. http://d-nb.info/1064760856/34.

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4

Carvalho, Luciane Carneiro de. "Avaliação clínica, laboratorial, genética e ovariana de pacientes 46,XX com deficiência da atividade do P450c17: uma revisão." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-04082015-112303/.

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A hiperplasia adrenal congênita (HAC) por deficiência no P450c17 é uma doença de herança autossômica recessiva raramente relatada em pacientes 46, XX. Nosso objetivo foi o de caracterizar o fenótipo e genótipo desta doença rara revendo os dados clínicos, laboratoriais, genéticos, e da função ovariana de pacientes 46,XX de uma coorte brasileira avaliada no HCFMUSP e dos casos já publicados na literatura. Foram avaliados retrospectivamente os dados de 18 pacientes brasileiras pertencentes a 12 famílias avaliadas no HCFMUSP, e revisados os dados de literatura de pacientes de 10 coortes com defici
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5

Picard, Mireille. "Le clonage et l'expression du cytochrome P450c17 humain dans le but d'étudier le rôle de la phosphorylation dans son activation." Sherbrooke : Université de Sherbrooke, 2003.

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6

Picard, Mireille. "Le clonage et l'expression du cytochrome P450c17 humain dans le but d'étudier le rôle de la phosphorylation dans son activation." Mémoire, Université de Sherbrooke, 2003. http://savoirs.usherbrooke.ca/handle/11143/3339.

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Le but de ce projet est d'étudier la phosphorylation sur le P450c17 humain. Un clone a donc été construit à partir de l'ARN extrait de glandes surrénales foetales et de cellules H295R. Une RT-PCR a été réalisée afin d'amplifier la séquence codante du P450c17, soit 1725 pb. Une fois l'ADNc humain cloné, séquencé et corrigé, son expression a été étudiée dans les cellules COS-1 (ces cellules ont été choisies car elles n'expriment pas le P450c17) à l'aide du vecteur pcDNA3.1/V5-His[indice supérieur Copyright]TOPO[indice supérieur Marque déposée]. Des tests d'optimisation de la transfection ont mon
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7

Béland, Fanny. "Impacts moléculaires d’un excès d’acides gras sur l’androgenèse des cellules surrénaliennes." Mémoire, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8848.

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Le syndrome des ovaires polykystiques (SOPK) touche entre 5 à 10 % des femmes en âge de procréer et est associé à de nombreuses complications. Ce désordre endocrinien est caractérisé par des niveaux circulants élevés d’androgènes, dont la production est principalement modulée par la P450c17 et son cofacteur, soit la P450oxydoréductase (POR). Plusieurs études démontrent que l’hyperandrogénie présente chez les femmes SOPK pourrait être causée par la formation de phénomènes toxiques survenant à la suite de l’exposition des tissus non adipeux à un excès d’acides gras non estérifiés (AGNE), appelé
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8

Santos, Amilton Cesar dos. "Expressão das enzimas: citocromo P450 aromatase, NADPH-citocromo P450 redutase e citocromo P450c17 (17-α-hidroxilase/17, 20-liase) na vagina de fêmeas de preás (Galea spixii, Wagler, 1831)." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-24092013-161549/.

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Para a metabolização de hormônios esteroides sexuais é essencial a participação de enzimas esteroidogênicas. A enzima citocromo P450c17 é responsável pela produção de andrógenos e a enzima citocromo P450 aromatase é responsável pela produção de estrógenos, sendo que, ambas as enzimas necessitam formar um complexo com uma enzima parceira, denominada NADPH citocromo P450 redutase, para realizar a metabolização destes hormônios essenciais para a diferenciação sexual. Objetivou-se imunolocalisar as três enzimas acima citadas no tecido vaginal de fêmeas de roedores Galea spixii. Para tanto, o exper
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9

Mathieu, Axel Patrick. "Modélisation moléculaire de la protéine "Steroidogenic Acute Regulatory" (StAR) et du cytochrome P450 17[alpha]-hydroxylase/17,20-Lyase (P450c17) une approche moléculaire pour comprendre les mécanismes de la stéroïdogenèse." Thèse, Université de Sherbrooke, 2002. http://savoirs.usherbrooke.ca/handle/11143/4149.

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L'hyperplasie lipoïde surrénalienne congénitale a été attribuée à la protéine"steroidogenic acute regulatory" (StAR) portant des mutations qui inhibent sa fonction primaire. Nous avons donc entrepris des démarches pour clarifier le mécanisme d'action de la StAR en utilisant des techniques à la fine pointe de la technologie, telle que la modélisation moléculaire. Nous avons développé un modèle StAR basé sur les données cristallographiques de la protéine MLN64 humaine. Nous démontrons par notre modèle que StAR possède une cavité hydrophobe et non un tunnel tel qu'observé pour la molécule MLN64.
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Arroyo, Maria Angélica Machado. "Ultraestrutura e expressão das enzimas: citocromo P450 aromatase e citocromo P450c17 (17-α-hidroxilase/17,20-liase) nas diferentes fases do desenvolvimento da via espermática e espermatogênese em cutia (Dasyprocta sp.) criada em cativeiro." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-03122013-081304/.

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Espécies silvestres com grande potencial zootécnico devem ser exploradas de forma racional a fim de se evitar a extinção das mesmas. Assim se dá a importância de pesquisas voltadas à reprodução daquelas criadas em cativeiro, como a cutia (Dasyprocta sp.). Este animal é um mamífero e roedor vivente, em sua maioria, na Caatinga brasileira. A ultraestrutura é a base para determinar os estágios celulares e, assim, facilitar as comparações dos processos entre cutias e roedores silvestres ou outros mamíferos. As enzimas P450 aromatase e P450c17 são responsáveis pela regulagem da produção de estrógen
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11

Hawkes, David B. "Cytochrome P450cin /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17457.pdf.

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12

Özalp, R. Gözde [Verfasser]. "Lokalisation der 17α-Hydroxylase-C17,20-Lyase [17-alpha-Hydroxylase-C17,20-Lyase] (P450c17), 3β-Hydroxysteroiddehydrogenase-Δ-4/5-Isomerase [3-beta-Hydroxysteroiddehydrogenase-Delta-4-5-Isomerase] {(3βbeta-HSD) [(3-beta-HSD)]und Aromatase (P450arom) in der Plazenta beim Rind im Verlauf der Gravidität / R. Gözde Özalp". Wettenberg : VVB Laufersweiler, 2005. http://d-nb.info/974396028/34.

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Özalp, R. Gözde. "Lokalisation der 17[alpha]-Hydroxylase-C17,20-Lyase [17-alpha-Hydroxylase-C17,20-Lyase] (P450c17), 3[beta]-Hydroxysteroiddehydrogenase-D-4/5-Isomerase [3-beta-Hydroxysteroiddehydrogenase-Delta-4-5-Isomerase] (3[beta]beta-HSD) [(3-beta-HSD)]und Aromatase (P450arom) in der Plazenta beim Rind im Verlauf der Gravidität." Wettenberg : VVB Laufersweiler, 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974396028.

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Beresford, Alan Peter. "Drug interactions with cytochromes P4501A." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301011.

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Yasmin, Samina. "Engineering of P450cam for fine chemical synthesis." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497160.

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Lock, Ruth E. "Structure-activity relationships (SAR) for cytochrome P4502C19." Thesis, University of Aberdeen, 1999. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU535752.

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Investigation of structure-activity relationships (SAR) for cytochrome P450 isoenzymes has implications for the prediction of drug-drug interactions. To date, the majority of research relating to the structure-activity relationships for P450 isoenzymes has concentrated on CYP2D6, CYP2E1, and CYP2C9. Knowledge of the likelihood of an interaction between a new chemical entity (NCE) and CYP2C19 is also of interest due to the existence of a genetic polymorphism in this enzyme. SAR for CYP2C19 were investigated in human liver microsomes (n=3) and CYP2C19 SUPERSOMES<SUP>TM</SUP> (n=2), by determinin
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Yoshioka, Shiro. "ACTIVATION MECHANISM OF DIOXYGEN BY CYTOCHROME P450cam." Kyoto University, 2001. http://hdl.handle.net/2433/150660.

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Stevenson, Julie-Anne. "Selective oxidation of simple alkanes by cytochrome P450cam." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302491.

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Schöneboom, Jan Claasen Curd. "Combined quantum mechanical - molecular mechanical calculations on cytochrome P450cam." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968865267.

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Lajić, Svetlana. "Molecular analysis of mutated P450c21 in congenital adrenal hyperplasia /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980604laji.

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Eichler, Anja. "Investigations of self-sufficient P450cam monooxygenases for activity and enantioselectivity." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/investigations-of-selfsufficient-p450cam-monooxygenases-for-activity-and-enantioselectivity(27df0fa8-b671-4593-8ec0-f993a31e120c).html.

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Catalytic, selective C-H bond activation for the oxidative hydroxylation RH → ROH of simple or complex compounds is of significant interest in synthetic organic chemistry. One of the major classes of enzymes used for C-H bond activation are cytochrome P450 monooxygenases (EC 1.14.X.X), which can promote chemo-, regio- and stereoselective oxidations under mild reaction conditions. For the current study, catalytically self-sufficient forms of biocatalyst P450cam-RhFRed were investigated. These self-sufficient P450 systems were previously created by fusing the reductase domain of P450 RhF (CYP116
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Belsare, Ketaki Deepak [Verfasser]. "Directed evolution of P450cin for mediated electron transfer / Ketaki Deepak Belsare." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1065848250/34.

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23

MOURO, CORINNE. "Etudes spectroscopiques du cytochrome p450cam : analyses structurales par infrarouge de la conversion en cyt. p420 et caracterisation par rmn des formes diamagnetiques et paramagnetiques du cyt. p450cam." Rennes 1, 1998. http://www.theses.fr/1998REN10096.

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Le cytochrome p450cam est une hemoproteine d'origine bacterienne, de poids moleculaire 45 kda et qui possede la propriete interessante d'etre hydrosoluble. Cette caracteristique permet de l'etudier via differentes methodes spectroscopiques telles que la spectroscopie infrarouge et la resonance magnetique nucleaire (rmn). L'infrarouge par transformee de fourier est un bon outil pour analyser les alterations structurales associees a la conversion du cyt. P450cam en cyt. P420. Cette proteine est la forme inactive des cyt. P450. Sa formation par voie thermique ou chimique induit, a des degres diff
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Wang, Zhonghua. "Proton Nuclear Magnetic Resonance Investigation of the Native and Modified Active Site Structure of Heme Proteins." FIU Digital Commons, 2011. http://digitalcommons.fiu.edu/etd/513.

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Hemoproteins are a very important class of enzymes in nature sharing the essentially same prosthetic group, heme, and are good models for exploring the relationship between protein structure and function. Three important hemoproteins, chloroperoxidase (CPO), horseradish peroxidase (HRP), and cytochrome P450cam (P450cam), have been extensively studied as archetypes for the relationship between structure and function. In this study, a series of 1D and 2D NMR experiments were successfully conducted to contribute to the structural studies of these hemoproteins. During the epoxidation of allylbenze
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Filipović, Dorde. "Isolation and characterization of four new members of the rat P45011B subfamily /." Zürich, 1989. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=8882.

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Herve, Jessica. "Cytochrome P4501A induction by dioxin-like compounds in avian hepatocyte cultures." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28333.

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In this study, the potencies of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) and 2,3,7,8-tetrachlorodibenzofuran (TCDF) to induce cytochrome P4501A (CYP1A) were determined. The concentration-dependent effects of TCDD, PeCDF and TCDF on ethoxyresorufin O-deethylase (EROD) activity, CYP1A4 mRNA and CYP1A5 mRNA expression were measured in primary hepatocyte cultures of chicken (Gallus gallus), ring-necked pheasant (Phasianus colchicus), Japanese quail (Corturnix japonica ), and herring gull (Larus argentatus) embryos exposed for 24h. The results demonstra
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Tosha, Takehiko. "Molecular mechanism of cytochrome p450cam-catalyzed oxygenation reaction regulated by the association with putidaredoxin." 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/148546.

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Mundy, Lukas. "Cytochrome P4501A Induction by Highly Purified Hexachlorobenzene in Primary Cultures of Avian Hepatocytes." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20292.

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Hexachlorobenzene (HCB) is a persistent organic pollutant that was primarily produced for use as a fungicide dating back to the 1940s. Worldwide emissions have declined steadily over the past forty years, but HCB is still produced as a by-product of a number of industrial processes and is still detected in remote locations around the globe. Many studies have been conducted to determine the toxic and biochemical effects of HCB, but it has been suggested that reported toxic and biochemical effects initially attributed to HCB exposure may have actually been elicited by contamination of HCB by pol
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Lacour, Thierry. "Expression du cytochrome p45011 bovin dans la levure : identification d'un nouveau transporteur d'electrons." Université Louis Pasteur (Strasbourg) (1971-2008), 1997. http://www.theses.fr/1997STR13101.

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Dans le cadre d'un projet visant a reproduire la voie de biosynthese des hormones steroides dans la levure, nous avons etabli l'activite in vivo du cytochrome p45011 bovin dans les mitochondries de levure. Ces travaux mettent en evidence une nouvelle proteine de levure, yadr, capable de transferer les electrons indispensables a l'activite catalytique du cytochrome. Des analyses genetiques et biochimiques permettent de caracteriser cette proteine.
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Yin, Ming. "NMR study of interaction between cytochrome P450cam and putidaredoxin and structural study of cytochrome P450 3A4." Waltham, Mass. : Brandeis University, 2009. http://dcoll.brandeis.edu/handle/10192/23190.

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Bengtsson, Johanna. "The impact of cytochrome P4501-inhibitors on aryl hydrocarbon receptor signaling." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-128367.

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The aryl hydrocarbon receptor (AHR) best known as a ligand-activated transcription factor that mediates toxic responses to xenobiotics such as dioxins, is also activated by certain endogenous compounds. Activation of the AHR up-regulates transcription of a large number of genes, including those encoding members of the cytochrome P450 1 family of enzymes (CYP1s). Although the AHR has been shown to be involved in several normal processes, its physiological role remains elusive. The endogenous ligand 6-formylindolo[3,2-b]carbazole (FICZ), formed from tryptophan, is present in cell culture media a
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Meilleur, Flora. "Etudes cristallographiques aux rayons X et aux neutrons du cytochrome P450cam et de la D-xylose isomerase." Université Joseph Fourier (Grenoble), 2004. http://www.theses.fr/2004GRE10067.

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Les protons ont un rôle essentiel dans les mécanismes enzymatiques. Notre compréhension de ces processus peut donc grandement bénéficier de la localisation des hydrogènes aux sites actifs. Cette information peut-être obtenue par la cristallographie aux neutrons, aux résolutions modestes de 1. 5 - 2. 0 A. Cependant la cristallographie aux neutrons implique de nombreux challenges. De larges cristaux sont nécessaires pour palier aux faibles flux de neutrons disponibles. De plus, l'importante diffusion incohérente de l'hydrogène réduit considérablement le signal/bruit. Cela peut être contourné en
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Cochran, Maria Karin. "Uptake Routes of Benzo[a]pyrene in an Estuarine Killifish: Cytochrome P4501A Immunohistochemistry using Whole Fish." W&M ScholarWorks, 1994. https://scholarworks.wm.edu/etd/1539617672.

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Martins, Thiago Estevam Parente. "Estudo comparativo da atividade catalítica e expressão protéica do citodromo P4501A (CYP1A) em cascudos (Loricariidae e tilápias (Cichlidae)." reponame:Repositório Institucional da FIOCRUZ, 2008. https://www.arca.fiocruz.br/handle/icict/13493.

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Made available in DSpace on 2016-04-04T12:35:27Z (GMT). No. of bitstreams: 2 thiago_martins_ioc_mest_2008.pdf: 2240776 bytes, checksum: 22f0d88555ae7a38778dfd03f1dd7c9c (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2008<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil<br>Os citocromos P450 (CYP) desempenham importantes papéis na biotransformação de xenobióticos e no metabolismo de substâncias endógenas. A subfamília CYP1A foi bem conservada ao longo da evolução dos vertebrados, tendo sido encontrada em todas a
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Stien, Xavier. "Validation de biomarqueurs d'exposition pour la surveillance de l'environnement marin et clonage du cytochrome P4501A chez Dicentrarchus labraxI." Aix-Marseille 2, 1998. http://www.theses.fr/1998AIX22083.

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Des biomarqueurs d'exposition a differents polluants chimiques ont ete evalues chez des poissons, loups (dicentrarchus labrax), serrans (serranus cabrilla), anguilles (anguilla anguilla) et chez des moules (mytilus galloprovincialis) pour surveiller l'environnement aquatique. La mesure d'activite d'une enzyme de detoxication dependante du cytochrome p450, l'ethoxyresorufine o-desethylase (erod), a ete validee par une intercalibration inter-laboratoire. L'erod ainsi que d'autres biomarqueurs (acetylcholine esterase, glutathion s-transferase) ont ete mesures sur des poissons preleves en mediterr
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Baker, George. "The characterisation of the flavocytochrome P450-CPR fusion enzymes CYP505A30 from Myceliophthora thermophila and CYP102A1 from Bacillus megaterium." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/the-characterisation-of-the-flavocytochrome-p450cpr-fusion-enzymes-cyp505a30-from-myceliophthora-thermophila-and-cyp102a1-from-bacillus-megaterium(f064fb08-300f-4d09-a03a-f00017c4ba68).html.

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High catalytic activity and a broad substrate range are characteristic of P450 fusion enzymes of the CYP102A class. P450 BM3 (CYP102A1, BM3) is a paradigm for the P450 fusion enzymes and is accredited with the highest monooxygenase activity in the P450 superfamily, a property which has led to its engineering and exploitation for biotechnologically valuable oxidation reactions. Initial research in the thesis focused on characterisation of a novel P450-redox partner fusion enzyme from the thermophilic fungus Myceliophthora thermophila (CYP505A30, P450MT1). Sequence alignments revealed a P450 dom
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Fonseca, Casals Francina. "Pharmacogenomic study of oppioid addicts in methadone treatment / Francina Fonseca Casals." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7234.

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Although the well established efficacy of methadone maintenance treatment (MMT) in the opioid dependence disorder, there is a group of patients that are poor responders. The study of the influence of methadone pharmacodynamics and pharmacokinetics in dose requirements and program outcome remains still controversial. The aim of this dissertation is to study the pharmacodynamic and pharmacokinetic factors involved in the methadone maintenance treatment efficacy. <br/>The study recruited opioid dependence patients (DSM-IV criteria) from a MMT community program. Patients were clinically assessed a
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Soucy, Penny. "Rôle du cytochrome P450c17 et des composantes du système enzymatique actif dans la production sélective des précurseurs des glucocorticoïdes, des stéroïdes sexuels et des 16-ène-stéroïdes /." 2003. http://proquest.umi.com/pqdweb?did=765336471&sid=9&Fmt=2&clientId=9268&RQT=309&VName=PQD.

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Chada, Sirisha. "Cloning and expres[s]ion of cytochrome P450cam." 2004. http://etd.utk.edu/2004/ChadaSirisha.pdf.

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Thesis (M.S.)--University of Tennessee, Knoxville, 2004.<br>Title from title page screen (viewed Sept, 23, 2004). Thesis advisor: Abhijeet P. Borole. Document formatted into pages (x, 104 p. : ill. (some color)). Vita. Includes bibliographical references (p. 95-103).
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Shu-Wen, Cheng, та 鄭舒文. "Genetic Polymorphisms in Androgen Receptor and Cytochrome P450c17α and risk of hepatocellular carcinoma-A Case-Control Study". Thesis, 1999. http://ndltd.ncl.edu.tw/handle/95204024668882557881.

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碩士<br>國立臺灣大學<br>流行病學研究所<br>87<br>Objectives: This study was carried out to investigate the association between the polymorphic (CAG)n microsatellite in exon 1 of the androgen receptor (AR) gene and hepatocellular carcinoma (HCC) in men and the association of a polymorphism in cytochrome P450c17α (CYP17) gene with HCC in women. The interaction between CAG repeat lengths and serum testosterone levels, and the modification effects of certain reproductive factors on the risk of HCC associated with CYP17 genetic polymorphism were also evaluated. Methods: Genotyping was performed using PC
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Schöneboom, Jan Claasen Curd [Verfasser]. "Combined quantum mechanical - molecular mechanical calculations on cytochrome P450cam / vorgelegt von Jan Claasen Curd Schöneboom." 2003. http://d-nb.info/968865267/34.

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Chai-Li, Cheng, and 鄭佳俐. "Characterization of the regulatory element(s) controlling the adrenal-specific expression of human CYP21(P450c21) gene." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/11325128344093319744.

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碩士<br>台北醫學院<br>細胞及分子生物研究所<br>86<br>Steroid 21 hydroxylase (P450c21) is specifically expressed in the adrenal cort ex, and is required for the biosynthesis of steroid hormones. Enzymatic defici ency of 21-hydroxylase causes the congenital adrenal hyperplasia (CAH), an aut osomal recessive disorder. There are two copies of human steroid 21-hydroxylas e gene, the active CYP21 which encodes the enzyme, and the pseudogene, CYP21P. These two genes are localized on human chromosome 6p21.1, and duplicated in t andem with th
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Šalovská, Barbora. "Modulační účinky apigeninu a luteolinu na aktivitu a expresi cytochromu P4501A ve střevních buňkách." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-282962.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Title, Name, Surname of candidate: Barbora Šalovská Title, Name, Surname of tutor: Doc. RNDr. Lenka Skálová, Ph.D. Title of diploma thesis: Modulation effects of apigenin and luteolin on activity and expression of cytochrome P4501A2 in intestinal cells Flavonoids are a large group of polyphenolic compounds that occur naturally in plant kingdom. They have been shown to posses a variety of biological activities including anti-inflammatory, anti-oxidant and anti-mutagenic effects and play a promi
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Volková, Marie. "Modulační účinky quercetinu a rutinu na aktivitu a expresi cytochromu P4501A ve střevních buňkách." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-282974.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Marie Volková Supervisor: Doc. RNDr. Lenka Skálová, Ph.D. Title of diploma thesis: Modulatory effects of Quercetin and Rutin on the activity and expression of cytochrome P4501A in the intestinal cells Flavonoids originate as the secondary metabolites of plants and they are daily consumed in fruits and vegetables. They show the antioxidant, antiinflammatory, anticarcinogenic and other healthy effects. A potential anticarcinogenic effect is mediated by the strong antioxidant activity,
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Lin, Chia-Ching, and 林佳靜. "Biodegradation of Pentachloroethane by expressing the Pseudomonas putida Cytochrome P450cam in the purple non-sulfur phototrophic bacteria." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/35499540626178601073.

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碩士<br>國立中興大學<br>生命科學系所<br>96<br>Environmental contaminants, such as anthropogenic chlorinated compounds tri-chloroethylene (TCE) and tetrachloroethylene (PCE), can be reductively dehalogenated to less chlorinated ethenes or innocuous compounds by micro-organisms through halorespiration under anaerobic condition. The halorespiration is composed of electron donor, electron carrier, and electron acceptor. Most of these microorganisms can use hydrogen as electron donor to proceed reductive dehalogenation. The decomposition of chlorinated compound as the major targets for bioremediation with hydr
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WU, DU-AN, and 吳篤安. "1.STRUCTURE AND FUNCTION RELATIONSHIP OF HUMAN P450C21 2.STRUTURE AND CHROMOSOME ASSIGNMENT OF HUMAN FERREDOXIN GENE." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/26960450769668766125.

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關媺媺. "Structure-function studies of human P450c21 by site-directed mutagenesis:kinetic properties of mutants Thr295--->Ala295,Val295, and Ser295." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/99521064192808245188.

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