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Relevant bibliographies by topics / P53 apoptotic markers

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Academic literature on the topic 'P53 apoptotic markers'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "P53 apoptotic markers"

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MESSMER, Udo K., and Bernhard BRÜNE. "Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways." Biochemical Journal 319, no. 1 (1996): 299–305. http://dx.doi.org/10.1042/bj3190299.

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Nitric oxide (NO) generation initiates apoptotic cell death in different experimental systems. In RAW 264.7 macrophages the appearance of typical apoptotic markers is linked to inducible NO synthase induction. Mechanistically, accumulation of tumour suppressor p53 precedes apoptotic DNA fragmentation. With the use of S-nitroglutathione (GSNO) we correlated a dose-dependent p53 up-regulation to DNA fragmentation measured after 4 h and 8 h, respectively. Our studies revealed a linear correlation between the potency of five different NO donors with respect to apoptosis induction and p53 accumulat

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Panasyan, Artak U., D. S. Kobyakov, A. M. Avdalyan, et al. "EXPRESSION OF MARKERS OF APOPTOSIS (P53, BCL-2, BAX) AND PROLIFERATION (KI-67, TOPOISOMERASE IIA, ARGYROPHILIC PROTEINS OF NUCLEOLAR ORGANIZER REGIONS) IN HEALTHY PERSONS AND NON-SMALL CELL LUNG CANCER PATIENTS AND THEIR RELATIONSHIP WITH SOME CLINICAL AND MORPHOLOGICAL PARAMETERS." Russian Journal of Oncology 22, no. 3 (2017): 153–57. http://dx.doi.org/10.18821/1028-9984-2017-22-3-153-157.

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Study of markers of apoptosis and proliferation in relation to clinical and morphological parameters in non-small cell cancer (NSCLC) patients and healthy persons. There were investigated 237 surgery samples of NSCLC and 10 cases of normal lung tissues. p53, bcl-2, bax, Ki-67, topoisomerase IIα (ТороIIα) levels were determined by immunohistochemical method. Argyrophilic proteins associated with nucleolar organizer regions (AgNOR) were detected with silver nitrate. In NSCLC expression of p53, bcl-2, Ki-67, TopoIIα, AgNOR increased and expression of bax was lower if compared with the normal tiss

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Pérez-Mora, Salvador, Juan Ocampo-López, María del Consuelo Gómez-García, Sandra Viridiana Salgado-Hernández, Yazmin Montserrat Flores-Martinez, and David Guillermo Pérez-Ishiwara. "Polyphenols from Bacopa procumbens Nanostructured with Gold Nanoparticles Stimulate Hair Growth Through Apoptosis Modulation in C57BL/6 Mice." Pharmaceutics 17, no. 2 (2025): 222. https://doi.org/10.3390/pharmaceutics17020222.

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Background/Objectives: Alopecia is a hair disorder with a significant impact on quality of life, and its incidence has been increasing in recent years. Current therapeutic options are limited and may cause adverse side effects, highlighting the need to develop safer and more effective formulations. Therefore, the objective of this study was to evaluate the effect of a formulation based on the bioactive fraction of Bacopa procumbens (BFNB), conjugated with gold nanoparticles, on hair growth through the modulation of apoptosis in C57BL/6 mice. Methods: The potential biological activities of the

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Nur, Gokhan, Emrah Caylak, Pinar Aksu Kilicle, Safak Sandayuk, and Ozlem Onen Celebi. "Immunohistochemical distribution of Bcl-2 and p53 apoptotic markers in acetamiprid-induced nephrotoxicity." Open Medicine 17, no. 1 (2022): 1788–96. http://dx.doi.org/10.1515/med-2022-0603.

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Abstract Pesticides, which adversely affect the critical metabolic processes of organisms, disrupt the physiological balance by specifically targeting enzymes and may lead to such consequences that may lead to death. It provides benefits in agricultural activities. The p53 protein antagonizes bcl-2, an anti-apoptotic protein character, and induces apoptosis by causing mitochondrial membrane permeability. This study aims to show the effect of acetamiprid, which is an insecticide from the neonicotinoid class, on bcl-2 and p53 immunoreactivity, which has an important place in the apoptotic mechan

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Alonso, Roberto, Mónica López-Guerra, Ramanda Upshaw, et al. "Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM." Blood 114, no. 8 (2009): 1563–75. http://dx.doi.org/10.1182/blood-2009-02-207654.

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Abstract Chronic lymphocytic leukemia (CLL) is an incurable disease derived from the monoclonal expansion of CD5+ B lymphocytes. High expression levels of ZAP-70 or CD38 and deletions of 17p13 (TP53) and 11q22-q23 (ATM) are associated with poorer overall survival and shorter time to disease progression. DNA damage and p53 play a pivotal role in apoptosis induction in response to conventional chemotherapy, because deletions of ATM or p53 identify CLL patients with resistance to treatment. Forodesine is a transition-state inhibitor of the purine nucleoside phosphorylase with antileukemic activit

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Aggarwal, Dipanshu, Devi Charan Shetty, Anshi Jain, Nikita Gulati, and Saurabh Juneja. "Pathogenetic model of survivin-dependent molecular signalling pathways in tumorigenesis of oral cancer and precursor lesions." Journal of Oral and Maxillofacial Pathology 27, no. 2 (2023): 287–94. http://dx.doi.org/10.4103/jomfp.jomfp_5_23.

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Background: p53 tumour suppressor gene limits unchecked cellular growth in response to DNA damage, by causing G1 arrest and the activation of apoptosis. Inhibitors of apoptosis include survivin which acts by inhibition of caspases. Survivin has a significant role as a cell cycle modulator and is only minimally present in mature tissues. Aberrant expression of p53 and survivin has been evaluated in various carcinomas. Thus, the objective of this research was to elucidate the co-expression of p53 and survivin in tissue samples of Oral Potentially Malignant Disorders (OPMDs) and Oral Squamous Cel

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Mihoubi, Wafa, Emna Sahli, Fatma Rezgui, et al. "Whole and Purified Aqueous Extracts of Nigella sativa L. Seeds Attenuate Apoptosis and the Overproduction of Reactive Oxygen Species Triggered by p53 Over-Expression in the Yeast Saccharomyces cerevisiae." Cells 11, no. 5 (2022): 869. http://dx.doi.org/10.3390/cells11050869.

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Plants are an important source of pharmacologically active compounds. In the present work, we characterize the impact of black cumin (Nigella sativa L.) aqueous extracts on a yeast model of p53-dependent apoptosis. To this end, the Saccharomyces cerevisiae recombinant strain over-expressing p53 was used. The over-expression of p53 triggers the expression of apoptotic markers: the externalization of phosphatidylserine, mitochondrial defect associated with cytochrome-c release and the induction of DNA strand breaks. These different effects were attenuated by Nigella sativa L. aqueous extracts, w

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Munda, Mihael. "Molecular tissue markers integrated: A mathematical model approach to evaluating and predicting prostate cancer using molecular tissue markers." Acta Medico-Biotechnica 17, no. 2 (2024): 42–50. https://doi.org/10.18690/actabiomed.279.

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Purpose: The standard criteria available for the diagnosis of prostate cancer often do not sufficiently predict the course or outcome of this common disease. Evaluating molecular tissue markers, especially those that mark apoptosis and proliferation, in an integrated mathematical model, could contribute to a better understanding of the development and pathogenesis of this disease, aid in the selection of adequate therapies, and open new avenues of therapeutic research. Materials and methods: Paraffin-embedded prostatectomy specimens were stained according to an immunohistochemical protocol for

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El-Aal, Amany Ahmed Abd, Naglaa Saad Mahmoud El-Gebaly, Abeer Said Al-Antably, Marwa Adel Hassan, and Marwa Ahmed El-Dardiry. "Post-immunization immunohistochemical expression of Caspase 3 and p53 apoptotic markers in experimental hydatidosis." Revista Brasileira de Parasitologia Veterinária 25, no. 3 (2016): 333–40. http://dx.doi.org/10.1590/s1984-29612016058.

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Abstract The aim of this study was to investigate post-immunization apoptotic changes in experimental hydatidosis, using Caspase 3 and p53 immunohistochemical markers. Two groups of rabbits were immunized with a crude antigen (group 1) or a partially purified antigen (group 2) and were compared to an infected non-immunized control group. More effective immune responses were obtained in group 2 than group 1, signified by fewer and smaller cystic lesions and more severe destructive changes. Normal growth of cysts was attained in the control group, with no expression of apoptotic markers. Signifi

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Erdogan, Mehmet Kadir, and Guleser Ozer. "Synergistic Anticancer Effects of Bleomycin and Hesperidin Combination on A549 Non-Small Cell Lung Cancer Cells: Antiproliferative, Apoptotic, Anti-Angiogenic, and Autophagic Insights." Pharmaceuticals 18, no. 2 (2025): 254. https://doi.org/10.3390/ph18020254.

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Background: This study investigated the combined effects of hesperidin (Hesp), a natural flavonoid, with bleomycin (BL), a commonly used chemotherapy agent, on A549 human lung cancer cells. Methods: Key parameters assessed included cell viability, colony formation, and cell migration, alongside the expression of apoptotic and autophagic markers (p53, p21, Bax, cleaved PARP, and Beclin-1), VEGF levels, and caspase-3 activity. Results: The findings revealed that the Hesp + BL combination significantly amplified antiproliferative, apoptotic, anti-angiogenic, and autophagic effects compared to eit

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Book chapters on the topic "P53 apoptotic markers"

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Khutaeva, Karina Alievna, and Alexey Alexandrovich Demidov. "LEVELS OF APOPTOSIS MARKER PROTEINS - P53 AND BL-2 IN ELDERLY PATIENTS." In LEVELS OF APOPTOSIS MARKER PROTEINS - P53 AND BL-2 IN ELDERLY PATIENTS. ICSP "NEW SCIENCE", 2024. http://dx.doi.org/10.46916/09042024-4-978-5-00215-345-9.

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Cescato, VAS, EM Pinto, NR de Castro Musolino, SAC Siqueira, and MJ Teixeira. "BCL2, BAX and CASP3 Apoptosis Related Genes Expression in Non-Functioning Pituitary Adenoma and Their Role as Potential Markers of Tumor Behavior." In The Endocrine Society's 92nd Annual Meeting, June 19–22, 2010 - San Diego. Endocrine Society, 2010. http://dx.doi.org/10.1210/endo-meetings.2010.part1.p5.p1-240.

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Conference papers on the topic "P53 apoptotic markers"

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Herlambang, Herlambang, Rina Nofri Enis, Susan Tarawifa, and Tia Wida Ekaputri. "Identification of Apoptosis Marker in Preeclampsia: A Pre-Eliminary Study of P53 Gene Expression in Human Placenta." In The 3rd Green Development International Conference (GDIC 2020). Atlantis Press, 2021. http://dx.doi.org/10.2991/aer.k.210825.038.

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