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Dissertations / Theses on the topic 'P53 polymorphism'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Glas, Michael. "Mutationsanalyse im p53-Gen bei Patienten mit Multipler Sklerose." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969662440.

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2

Makni, Héla. "p53 polymorphism at codon 72 and risk of HPV-induced cervical cancer." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ64401.pdf.

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3

Koushik, Anita. "The p53 CODON 72 polymorphism and risk of pre-invasive cervical neoplasia /." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84277.

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Introduction. The Arg/Arg genotype vs. Arg/Pro or Pro/ Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to the action of human papillomaviruses (HPV) and thus altering cancer risk. However, research on this topic has been contentious. Meta-analysis and meta-regression analysis, included as part of this project, revealed that studies where departures from Hardy-Weinberg equilibrium were observed tended to report higher odds ratios (OR). In fact, several methodological and study design choices can contribute to such departures. The primary pur

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XUE, BIN. "META ANALYSIS OF THE ASSOCIATION OF p53 CODON 72 VARIATION AND CERVICAL CANCER." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1108234287.

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5

Ryk, Charlotta. "Influence of genetic polymorphisms on DNA repair, p53 mutations and cancer risk /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-940-8/.

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OKADA, RIEKO, BAKHODIR RAHIMOV, KEUN SOO AHN, et al. "INTERLEUKIN-8 T-251A POLYMORPHISM WAS ASSOCIATED WITH POSITIVE ANTI-p53 ANTIBODIES IN UZBEKISTAN POPULATION." Nagoya University School of Medicine, 2009. http://hdl.handle.net/2237/12351.

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7

ZIHA, ZARIFI ISABELLE. "Mutations de la p53 dans les cancers du sein : optimisation des conditions de single strand conformation polymorphism." Besançon, 1993. http://www.theses.fr/1993BESA3105.

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Ribeiro, Júnior Circoncisto Laurentino. "ANÁLISE DO POLIMORFISMO DO GENE P53 EM PACIENTES COM CLÍNICA DE ENDOMETRIOSE ASSOCIADO À INFERTILIDADE." Pontifícia Universidade Católica de Goiás, 2009. http://localhost:8080/tede/handle/tede/2419.

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Made available in DSpace on 2016-08-10T10:39:21Z (GMT). No. of bitstreams: 1 CIRCONCISTO LAURENTINO RIBEIRO JUNIOR.pdf: 2083186 bytes, checksum: bfcfede933b252abac1e5de63aa561f2 (MD5) Previous issue date: 2009-03-13<br>Endometriosis it is considered as the presence of ectopic endometrial tissue, with similar histology and function to the endometrium usually located. However, the explanation for the implantation of the endometrial tissue in certain women is still unknown. The determination of the degree of compromising of the endometriosis is based on a system of points proposed by American F

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Sarhanis, P. "Epithelial ovarian cancer : influence of polymorphism at the glutathione - s - transferase GSTM1 and GSTT1 loci on expression of P53." Thesis, Keele University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359971.

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Fagundes, Simone Souza. "RELAÇÃO DO POLIMORFISMO DO GENE TP53 NO CÓDON 72 COM CÂNCER DE MAMA: UMA ATUALIZAÇÃO DE METANÁLISE (2002-2015)." Pontifícia Universidade Católica de Goiás, 2016. http://tede2.pucgoias.edu.br:8080/handle/tede/3524.

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Submitted by admin tede (tede@pucgoias.edu.br) on 2016-10-07T13:26:52Z No. of bitstreams: 1 SIMONE SOUZA FAGUNDES.pdf: 1864838 bytes, checksum: 28db816101558781ede4b2fb42be7695 (MD5)<br>Made available in DSpace on 2016-10-07T13:26:52Z (GMT). No. of bitstreams: 1 SIMONE SOUZA FAGUNDES.pdf: 1864838 bytes, checksum: 28db816101558781ede4b2fb42be7695 (MD5) Previous issue date: 2016-06-27<br>Breast cancer is the most frequent in the world and Brazilian women, except for cases of skin cancer nonmelanoma. It is a complex disease that has no single cause, results from the interaction of multiple ri

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COSTA, Kárita Antunes. "Estudo de associação do polimorfismo de base única no códon 72 do gene humano p53 e as características de pigmentação." Universidade Federal de Goiás, 2010. http://repositorio.bc.ufg.br/tede/handle/tde/1243.

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Made available in DSpace on 2014-07-29T15:16:28Z (GMT). No. of bitstreams: 1 karita antunes costa.pdf: 2247292 bytes, checksum: e3c53812f8fcfba9aaaf69bdcbf978e3 (MD5) Previous issue date: 2010-03-30<br>The p53 gene encodes a protein which has various functions such as monitoring of the cell cycle, role in repair mechanisms and apoptosis. New functions performed by this protein have been observed and studied as acting in the cascade of skin pigmentation by acting as transcription factor for genes important in this process as POMC (pro-opiomelanocortin) and MC1R (melanocortin receptor 1). Amon

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Oliveira, Cristiane de 1985. "Influência dos polimorfismos P53 ARG72PRO, MDM2 T309G, BCL2 C(-938)A e BAX G(-248)A, relacionados com apoptose celular, na susceptibilidade ao melanoma cutâneo = Influence of the polymorphisms P53 ARG72PRO, MDM2 T309G, BCL2 C (-938) A and BAX G (-248) A, involved with cellular apoptosis, incutaneous melanoma susceptibility." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308612.

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Orientador: Carmen Silvia Passos Lima<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas.<br>Made available in DSpace on 2018-08-20T16:27:57Z (GMT). No. of bitstreams: 1 Oliveira_Cristianede_M.pdf: 2437379 bytes, checksum: 5fff08e294a7f4c2d2e6e49723726b29 (MD5) Previous issue date: 2012<br>Resumo: Os genes P53 e BAX (pró-apoptóticos) e MDM2 e BCL2 (antiapoptóticos) atuam na morte de células epiteliais danificadas por raios ultravioleta (UV) da luz solar e estão relacionados com a origem do melanoma cutâneo (MC). A proteína codificada pelo alelo selva

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Portari, Elyzabeth Avvad. "Estudo de polimorfismos nos genes TP53 e p21(WAF1) e do perfil imunohistoquímico das proteínas p53, p21(WAF1), p16(INK4a) e ciclina D1 pela técnica de Tissue Microarray (TMA) e sua importância para o desenvolvimento e/ou severidade das neoplasias cervicais." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9228.

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O câncer de colo do útero é o terceiro tipo de câncer mais frequente em mulheres no mundo, e a infecção persistente pelo papilomavirus humano (HPV) oncogênico é condição necessária, mas não suficiente para seu desenvolvimento. As oncoproteínas virais E6 e E7 interferem direta ou indiretamente na ação de várias proteínas celulares. Entretanto, as variantes proteicas, resultantes de polimorfismos genéticos, podem apresentar comportamento distinto mediante a infecção pelo HPV. O objetivo deste estudo foi avaliar possíveis associações entre polimorfismos nos genes TP53 (p53 PIN3, p53 72C>G) e p21

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14

Fernandes, Simone Crestoni [UNESP]. "Análise mutacional da região dos exons 5 a 8 do gene supressor de tumor p53 em neoplasias mamárias caninas." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/89060.

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Made available in DSpace on 2014-06-11T19:23:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-03-07Bitstream added on 2014-06-13T18:19:52Z : No. of bitstreams: 1 fernandes_sc_me_jabo.pdf: 542693 bytes, checksum: f141575a6f8b47f554e2e0bf4870259f (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Visando à contribuição ao estudo da oncologia e ao aumento da sobrevida de cadelas com neoplasias mamárias, o objetivo deste trabalho é investigar as possíveis alterações no gene supressor de tumor p

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15

Fernandes, Simone Crestoni. "Análise mutacional da região dos exons 5 a 8 do gene supressor de tumor p53 em neoplasias mamárias caninas/." Jaboticabal : [s.n.], 2008. http://hdl.handle.net/11449/89060.

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Resumo: Visando à contribuição ao estudo da oncologia e ao aumento da sobrevida de cadelas com neoplasias mamárias, o objetivo deste trabalho é investigar as possíveis alterações no gene supressor de tumor p53 em tumores de mama relacionando-as com a idade, raça, tipo histológico, número e localização da neoplasia, tempo de progressão e característica macroscópica do tumor (tamanho e presença de úlcera). Foram avaliadas 30 amostras de neoplasias de mama de cadelas. Este material foi distribuído em cinco grupos, de acordo com a classificação histopatológica do tumor (adenoma, tumor misto benign

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16

Zainuddin, Norafiza. "Molecular Genetic Analysis in B-cell Lymphomas : A Focus on the p53 Pathway and p16INK4a." Doctoral thesis, Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113970.

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The presence of TP53 mutations has been associated with inferior outcome in diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL). In DLBCL, the impact of the TP53 codon 72 polymorphism and MDM2 SNP309 has not been clearly elucidated, whereas MDM2 SNP309 was suggested as a poor-prognostic marker in CLL. In addition, p16INK4a promoter hypermethylation has been implicated as a negative prognostic factor in DLBCL. The aim of this thesis was to further evaluate these molecular markers in well-characterised materials of DLBCL and CLL. In paper I, we investigated the prognosti

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Cortezzi, Sylvia Sanches. "Papilomavírus humano e polimorfismo do gene TP53 no carcinoma espinocelular de cabeça e pescoço /." São José do Rio Preto : [s.n.], 2002. http://hdl.handle.net/11449/92507.

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Resumo: O carcinoma espinocelular de cabeça e pescoço é uma neoplasia cujo principal fator de risco é o consumo de tabaco e/ou álcool. As infecções pelo HPV têm sido observadas nesse grupo de tumores. Os HPVs de alto risco podem induzir alterações calulares pela interação de suas proteínas E6 e E7 com as proteínas p53 e a pRb, respectivamente. As oncoproteínas são insuficientes para o desenvolvimento do fenótipo maligno, sugerindo a presença de outros cofatores, como a susceptibilidade genética. O gene TP53 possui um polimorfismo que resulta na presença de uma prolina ou de uma arginina na pos

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Lima, Junior Mario Maciel de 1974. "Avaliação antropométrica, prostatica e polimorfismos de TP53 e GSTP1 em populações do estremo setentrional amazônico." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310299.

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Orientadores: Laura Sterian Ward, Ubirajara Ferreira<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T18:25:14Z (GMT). No. of bitstreams: 1 LimaJunior_MarioMacielde_D.pdf: 2397268 bytes, checksum: 63d55e4a5572d5d7f06e615be4d98384 (MD5) Previous issue date: 2012<br>Resumo: As doenças da glândula prostática em geral e a incidência de câncer da próstata, em particular, mostram disparidades acentuadas entre os diferentes países e etnias. De fato, etnia, idade e história familiar são os mais fortes fatores de risco co

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SILVA, Antonio Márcio Teodoro Cordeiro. "O polimorfismo do gene p5372(RP) no câncer de cabeça e pescoço: estudo de associação e meta-análise." Universidade Federal de Goiás, 2009. http://repositorio.bc.ufg.br/tede/handle/tde/1012.

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Made available in DSpace on 2014-07-29T15:10:31Z (GMT). No. of bitstreams: 1 antonio marcio.pdf: 1664898 bytes, checksum: a51767c9c1070efdc7346160e72afa12 (MD5) Previous issue date: 2009-10-20<br>Head and neck cancer arises in the oral cavity and nearby regions, larynx, pharynx, including oropharynx, nasopharynx, and hipopharynx. Extensive epidemiologic studies have revealed that chronic tobacco smoking and alcohol consumption as the two main risk factors associated with the multifactorial etiology of head and neck cancers. Additionally, nutritional status, HPV infection, and genetic polymor

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SILVA, Cláudio Carlos da. "Avaliação Genético-Molecular do Carcinoma das Células Escamosas da Laringe." Universidade Federal de Goiás, 2009. http://repositorio.bc.ufg.br/tede/handle/tde/1009.

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Made available in DSpace on 2014-07-29T15:10:31Z (GMT). No. of bitstreams: 1 claudio carlos.pdf: 4222908 bytes, checksum: 9eff1b9f349ce5868c10ca1d5b440898 (MD5) Previous issue date: 2009-10-21<br>The larynx is a structure of the upper aerodigestive tract responsible for the production of sounds as well as protecting the lower airways and helping during the normal act of swallowing. Any pathology which affects the larynx can impose several challenges that disrupt its normal physiological function, and consequently and directly resulting in reduction of the patient s quality of life. Among the

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Almeida, Priscilla Silva Rosa de. "POLIMORFISMO DO GENE TP53 EM SARCOMAS DE PARTES MOLES NO ADULTO." Pontifícia Universidade Católica de Goiás, 2008. http://localhost:8080/tede/handle/tede/2412.

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Made available in DSpace on 2016-08-10T10:39:18Z (GMT). No. of bitstreams: 1 PRISCILLA SILVA ROSA DE ALMEIDA.pdf: 3720637 bytes, checksum: b39a9c071d90058d47a3a8c7aec2c7f3 (MD5) Previous issue date: 2008-07-21<br>Soft tissue sarcomas (STS) are tumors with mesodermical origin, comprising about 1% of all adult neoplasms. Because of its effect on the p53 protein coding sequence, and its association with an increased risk for some cancer types, TP53 codon 72 polymorphism has been investigated in several studies. TP53 codon 72 codes for either Arginine (p53Arg), or Proline (p53Pro) at the p53 pro

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Cortezzi, Sylvia Sanches [UNESP]. "Papilomavírus humano e polimorfismo do gene TP53 no carcinoma espinocelular de cabeça e pescoço." Universidade Estadual Paulista (UNESP), 2002. http://hdl.handle.net/11449/92507.

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Made available in DSpace on 2014-06-11T19:26:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2002-08-23Bitstream added on 2014-06-13T20:54:02Z : No. of bitstreams: 1 cortezzi_ss_me_sjrp.pdf: 512438 bytes, checksum: c98927f964472197d57903b9dbd21cb1 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O carcinoma espinocelular de cabeça e pescoço é uma neoplasia cujo principal fator de risco é o consumo de tabaco e/ou álcool. As infecções pelo HPV têm sido observadas nesse grupo de tumores. Os HPVs de alto risco podem induzir alterações calulares pela interação de sua

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Silva, Kleber Santiago Freitas e. "POLIMORFISMOS GENÉTICOS EM PACIENTES DE GOIÂNIA COM ENDOMETRIOSE: UM ESTUDO ANALÍTICO." Pontifícia Universidade Católica de Goiás, 2013. http://localhost:8080/tede/handle/tede/2366.

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Made available in DSpace on 2016-08-10T10:38:42Z (GMT). No. of bitstreams: 1 KLEBER SANTIAGO FREITAS E SILVA.pdf: 1080005 bytes, checksum: 9dfcb821b9cd1574718e2442cabc533b (MD5) Previous issue date: 2013-02-18<br>In healthy women, a great number of intra and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. In endometriosis, abnormalities in those controls can lead to the survival of endometrial cells and consequently their attachment to the peritoneal cavity and disease progression. Endometrial cells with genetic polymorphisms respond to local sig

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Rabachini, Tatiana. "Polimorfismo do códon 72 do gene p53 e risco de infecções persistentes por papiloma vírus humano (HPV) e neoplasia do colo uterino." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-14052018-121907/.

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Nos últimos anos, inúmeros estudos epidemiológicos evidenciaram a forte associação entre o carcinoma do colo uterino e a infecção por papilomavírus humano (HPV). Esta associação deriva do reconhecimento de que estes vírus codificam oncoproteínas, dentre as quais E6 e E7, que apresentam propriedades transformantes. O produto do gene E7 se liga ao produto do gene retinoblastoma que perde a sua função de regular negativamente o ciclo celular. O produto do gene E6 se liga ao produto do gene supressor de tumor p53 levando a sua degradação pela via de proteólise dependente de ubiquitina. O gene p53

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Ståhl, Patrik L. "Methods for Analyzing Genomes." Doctoral thesis, KTH, Genteknologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12407.

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The human genome reference sequence has given us a two‐dimensional blueprint of our inherited code of life, but we need to employ modern‐day technology to expand our knowledge into a third dimension. Inter‐individual and intra‐individual variation has been shown to be larger than anticipated, and the mode of genetic regulation more complex. Therefore, the methods that were once used to explain our fundamental constitution are now used to decipher our differences. Over the past four years, throughput from DNA‐sequencing platforms has increased a thousand‐fold, bearing evidence of a rapid develo

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Gowrisankar, Sivakumar. "Predicting Functional Impact of Coding and Non-Coding Single Nucleotide Polymorphisms." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1225422057.

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Leon, Priscila Marques Moura de. "Genômica aplicada à reprodução equina." Universidade Federal de Pelotas, 2011. http://guaiaca.ufpel.edu.br/handle/123456789/1221.

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Made available in DSpace on 2014-08-20T13:32:48Z (GMT). No. of bitstreams: 1 tese_priscila_marques_moura_de_leon.pdf: 3035474 bytes, checksum: 1dfa2e910533e830f4c6c01d06ca37e6 (MD5) Previous issue date: 2011-11-07<br>In equine, the intersections between reproduction and genomics are numerous, however, little known about the genetic factors that acting on fertility. The conclusion of equine genome sequencing project, brings the oportunity to evaluate candidate genes and molecular biomarkers for specific reproductive characteristics. Based on this information, this PhD thesis aimed to devel

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Herzog, Raimund Ingo. "Ein Polymorphismus im Intron 3 des p53-Gens und erhöhtes Risiko für Ovarialkarzinom." Ulm : Universität Ulm, Medizinische Fakultät, 1998. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8619072.

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Kalita, Ann Marie. "Comparison of the activities of two allelic variants of the human wildtype p53 protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29729.pdf.

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Achatz, Maria Isabel Alves de Souza Waddington. "Modificadores de penetrância de mutações germinativas no gene TP53 em famílias brasileiras com diagnóstico clínico da síndrome de Li-Fraumeni e Li-Fraumeni like: impacto dos polimorfismos intragênicos do TP53 e de genes." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-29012009-172419/.

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A síndrome de Li-Fraumeni (LFS) e sua variante like (LFL) são associadas a mutações germinativas no gene TP53 e predispõe ao alto risco para múltiplos tumores em idade jovem. Analisamos 91 famílias LFS/LFL do sul/sudeste do Brasil para mutações germinativas e haplótipos de TP53 (PIN2, PIN3 e PEX4) e MDM2 (309T-G). A mutação R337H ocorreu em 44,4% das famílias avaliadas. Em 750 controles da região a freqüência populacional da mutação foi 0,3%. A genotipagem de oito indivíduos não relacionados R337H-positivos para 29 TAG SNPs intragênicos demonstrou o mesmo haplótipo raro estabelecendo efeito fu

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Sagne, Charlotte. "Polymorphisms in G-quadruplex regions of the TP53 tumour suppressor gene : Impact on cancer susceptibility and expression of p53 N-terminal isoforms." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T072/document.

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Le gène TP53 est extrêmement polymorphique avec 85 polymorphismes décrits. Certains de ces polymorphismes sont associés à une augmentation du risque de cancer, par exemple rs10425222 peut moduler les fonctions de p53. Cependant, pour d’autres, comme le rs17878362 qui est le polymorphisme intronique le plus étudié, leur association avec une augmentation du riques au cancer est controversée.Pour analyser l’association entre le polymorphisme rs17878362 et la susceptibilité au cancer, nous avons analysé son rôle dans des contextes de cancers sporadiques et familiaux. Les résultats obtenus pour le

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Grochola, Lukasz Filip. "Identification and functional analysis of single nucleotide polymorphisms that affect human cancer." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:aacc7084-81a8-4e97-b1ac-024d9bed106e.

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Aims: The p53 regulatory network is crucial in directing the suppression of cancer formation and mediating the response to commonly used cancer therapies. Functional genetic variants in the genes comprising this network could help identify individuals at greater risk for cancer and patients with poorer responses to therapies, but few such variants have been identified as yet. Methods: We first develop and apply three different screens that utilize known characteristics of functional single nucleotide polymorphisms (SNPs) in the p53 network to search for variants that associate with allelic dif

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Santos, Luis Eduardo Murgel de Castro. "Analise da influencia dos polimorfismos de P53 no cancer de bexiga." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310271.

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Orientador: Laura Sterian Ward<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-15T03:45:50Z (GMT). No. of bitstreams: 1 Santos_LuisEduardoMurgeldeCastro_D.pdf: 684034 bytes, checksum: 23d763337837e7c15426a84955a7074e (MD5) Previous issue date: 2009<br>Resumo: Vários estudos já investigaram a associação do polimorfismo do códon 72 de P53 (P53 Arg72Pro) a um risco aumentado para desenvolver câncer de bexiga, com resultados controversos. Aproveitando a diversidade étnica da população brasileira, nós genotipamos 94 ind

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Herzog, Raimund Ingo [Verfasser]. "Ein Polymorphismus im Intron 3 des p53-Gens und erhöhtes Risiko für Ovarialkarzinom / Raimund Ingo Herzog." Ulm : Universität Ulm. Medizinische Fakultät, 2000. http://d-nb.info/1015948782/34.

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Jung, Juliane [Verfasser], J. [Akademischer Betreuer] Dittmer, and J. [Akademischer Betreuer] Sehouli. "Prognostische Bedeutung von Mutationen und Polymorphismen im p53-Tumorsuppressorpathway in Ovarialkarzinomen / Juliane Jung. Betreuer: J. Dittmer ; J. Sehouli." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2012. http://d-nb.info/1025352815/34.

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Groß, Sebastian [Verfasser], F. [Akademischer Betreuer] Bartel, A. [Akademischer Betreuer] Simm, and Ch [Akademischer Betreuer] Blattner. "Bedeutung von Polymorphismen in Genen des p53-Pathways für das Altern / Sebastian Groß. Betreuer: F. Bartel ; A. Simm ; Ch. Blattner." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2014. http://d-nb.info/1049687523/34.

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Humbey, Olivier. "Étude du polymorphisme du résidu 72 de la protéine suppresseur de tumeur p53 dans la carcinogenèse épithéliale associée à l'infection par HPV." Besançon, 2004. http://www.theses.fr/2004BESAA007.

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Les papillomavirus humains (HPV) sont des virus ubiquitaires strictement épithéliotropes dont plus de 120 types ont été identifiés à ce jour. Ils sont fréquemment associés au développement de tumeurs cutanéo-muqueuses bénignes (verrues, papillomes, condylomes) ou malignes (adénocarcinomes, carcinomes épidermoïdes). De nombreuses études épidémiologiques ont permis de confirmer que certains HPV muqueux, dits à haut risque oncogène, sont responsables du développement du cancer du col de l'utérus, qui constitue le modèle de cancer induit par les HPV le mieux caractérisé. En effet, les mécanismes m

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Marcel, Virginie. "Régulation transcriptionnelle des isoformes de la protéine suppresseur de tumeur p53 tronquée dans leur région amino-terminale : impact des polymorphismes du gène TP53." Thesis, Lyon 1, 2009. http://www.theses.fr/2009LYO10088.

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Le gène suppresseur de tumeurs TP53 exprime plusieurs isoformes, dont Δ40p53 (perte du domaine de transactivation) et Δ133p53 (perte du domaine de transactivation et d’une partie du domaine de liaison à l’ADN). Ces isoformes inhibent l’activité suppressive de p53 et seraient sur-exprimées dans les cancers (sein et mélanome). Dans les cancers faiblement associés à une mutation TP53, ces isoformes seraient de bons candidats pour inactiver p53. Il convient de comprendre les mécanismes transcriptionnels qui régulent leurs expressions. Δ133p53 est produite par un promoteur alternatif P3 localisé da

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Huwer, Judith Stephanie [Verfasser], та Gunter [Akademischer Betreuer] AßMann. "p53-, Mdm2-, NF-κB-, pNF-κB-, p21-Expression und Apoptoseraten des Synoviozyten von Patienten mit rheumatoider Arthritis und Arthrose in Abhängigkeit von den p53 (G72C)- und Mdm2 (T309G)-DNA-Polymorphismen / Judith Stephanie Huwer. Betreuer: Gunter Aßmann". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2014. http://d-nb.info/1058586513/34.

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Zattra, Edoardo. "Analisi di polimorfismi genetici del gene TP53 e del gene EGF in pazienti con nevi melanocitici multipli." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3422737.

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Background: p53 have been extensively reported in the literature to be able to modify the activity of melanocytes, particularly in controlling the proliferation of these cells. P53 is a transcriptional activator of genes encoding for proteins that influence the proliferation of melanocytes and in this way the onset and progression of malignant melanoma. Epidermal Growth Factor (EGF) is a growth factor member of the EGF superfamily. It has been shown that it activates cell proliferation and stimulates mitogenesis in epidermal tissue, enhancing tumor growth. The presence of more than 100 nevi ha

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Chiou, Jau-Cheng, and 邱肇誠. "Effect of the 72nd amino acid polymorphism on p53 transactivation." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/60538746116302905714.

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碩士<br>國立成功大學<br>生物化學研究所<br>89<br>p53 tumor suppressor gene is a nucleus transcription factor. p53 involves in many physiological process including cell cycle arrest, apoptosis and prevention of genome instability. p53 regulates many downstream genes by transactivation. Missense mutation in p53 DNA binding domain corrupts p53 transactivation ability, and exhibits dominant negative effect against wild type p53. p53 72nd amino acid is a common polymorphic residue, which encodes arginine(R) or proline(P). The allelic frequency of R/P is about 6:4. p53 polymorphism correlates with some

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Huang, Yu, and 黃玉. "P53 exon 4 Polymorphism and The Pattern of P53 exon 5-8 Mutation in Lung Cancer Tissue." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/00346268851129490229.

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Lin, Ruey-Jen, and 林瑞珍. "The role of p53 polymorphism in cellular response to ionizing radiation." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/21944784224228032023.

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碩士<br>國立陽明大學<br>微生物暨免疫學研究所<br>89<br>p53 is a tumor suppresser gene that plays a central role in maintaining the genetic integrity of the cell. Upon DNA damage induced by irradiation, p53 is activated and induces expression of downstream target genes whose product trigger cell-cycle arrest, apoptosis and DNA repair. Thus p53 is the most crucial mediator of cellular response to irradiation. The human wild type p53 exhibits a common polymorphism in the general population that encodes either a proline (p53-Pro) or an arginine (p53-Arg) residue at position 72. It has been show that the two polymorp

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Hsia, Te-Chun, and 夏德椿. "Relationship between p53 codon 72 polymorphism and chemoresistance in lung cancer patients." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/24080817409916392686.

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碩士<br>中國醫藥學院<br>醫學研究所<br>88<br>Polymorphism of p53 codon 72 was extensively studied to determine the risk factors responsible for cancer formation. A single base change from G to C caused the alteration of amino acid residue 72 from arginine to proline. Arginine form is considered to be a significant risk factor in the development of cancer. However, proline form homozygotes has highly associated with cancer formation or tumor invasiveness in Taiwanese patients with lung, hepatocellular and bladder cancers. To resolve the undefined distribution of this polymorphism in patients with far-advan

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Soliman, Alia [Verfasser]. "p53 codon 72 polymorphism in HPV-related cervical cancer / von Alia Soliman." 2011. http://d-nb.info/1013068998/34.

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Lin, Yuh-cheng, and 林育成. "Detection of p53 gene mutation in human breast neoplasm with single-strand conformation polymorphism and direct cyclic sequencing." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/36528981266891361444.

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碩士<br>國立成功大學<br>藥理學研究所<br>85<br>p53是一種癌症抑制基因(tumor supressor gene)，在人類常見的癌症當中，可發現p53基因的等位基因缺失(allelic deletion)或點突變(point mutation)所造成的功能喪失。當DNA受到了損傷之後，p53蛋白的量在細胞內急遽增加，隨之使細胞週期停留在G1期；細胞若包含突變的p53或缺乏p53則不能誘導此種細胞週期停止。此外，突變的p53基因使細胞進行計畫性細胞自殺(apoptosis)的能力降低，因此癌細胞內的p53基因若突變則其對化學療法或放射線療法將具有抵抗性。在與其他種致癌基因比較之下，p53基因的突變或缺失是在乳房癌中最常見的基因變化。因此，若能建立p53基因與乳房癌惡化程度之間的關係，將有助於診斷乳房癌或者評估其在治療後復發的可能性。本實驗的目的在於偵測不同病期的乳房癌中其 p53基因突變的情形，藉此來推斷乳房癌的預後(prognosis)。我們首先利

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Badr, Idsaid. "The Role of miR-605 and its Variant in Li-Fraumeni Syndrome." Thesis, 2014. http://hdl.handle.net/1807/44027.

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Li-Fraumeni Syndrome (LFS) is a rare cancer predisposition syndrome, typically involving germline mutations in the TP53 gene. Despite the high penetrance of TP53 mutations, LFS patients display striking phenotypic differences, suggesting the presence of secondary risk loci. To date, all genetic modifiers in LFS have been shown to map to either TP53 or its principal negative regulator, Mdm2. Given this strong association, we set out to interrogate the contribution of a recently-described miRNA regulator of the p53-MDM2 loop, called miR-605. We hypothesized that, if functional, the miR-605 gene

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Lin, Chun-Hsuan, and 林君璇. "Association of APE1 Asp148Glu and hOGG1 Ser326Cys polymorphism with Taiwanese non small cell lung cancer risk and p53 mutation occurrence." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/76124499368594651989.

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博士<br>國立交通大學<br>生物科技學系<br>100<br>Statistic database from DOH, ROC showed that lung cancer is the first and second cause of cancer death in Taiwanese women and men, respectively. Patients with lung cancer had 15% of 5-year survival rate revealing that establishing risk markers for early detection of lung cancer is the most important strategy to reduce the death of this disease. Cigarette smoking is considered to be major cause of lung cancer and p53 mutation induced by smoke carcinogens plays a crucil role in lung cancer development. High frequency of p53 mutation occurred in patients smokers c

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Huang, Hsin-I., and 黃馨儀. "A anlysis of the relationship between p53 and COX-2 gene polymorphism to oral squamous cell carinoma, and oral precancerous lesion." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/35838711794593058644.

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碩士<br>高雄醫學大學<br>口腔衛生科學研究所碩士班<br>95<br>Background: Inflammation and imbalances between cell proliferation and cell death are two important key factors for cancer development. COX-2 and p53 genes play important roles in inflammation and cell cycle regulation. Recent reports suggest that polymorphisms of p53 at codon 72 and COX-2 at promoter sequence -765G/C may act as risk factors for a variety of cancers. However, the associations between these two polymorphisms, oral precancerous lesions (OPL), and oral squamous cell carcinoma (OSCC) are unclear. In the present study, our aims were to determi

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Chi-Hsiang and 王吉祥. "The effects of single nucleotide polymorphism (rs648802) in PERP (p53 apoptosis effector related to PMP22) on lung cancer risk and prognosis in Taiwanese population." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/36925326223828726473.

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碩士<br>中山醫學大學<br>醫學分子毒理學研究所<br>99<br>PERP (P53 Apoptosis Effect Related to PMP-22) –a tetraspan protein is primarily localized at the plasma membrane. Previous studies suggested that PERP is a downstream target of P53 and its expression is related to p53-dependent apoptosis. Recently, PERP has been shown to affect phosphorlyation of p53 that promotes P53-dependent apoptosis by stabilizing active p53 and altering its cellular localization. We identified multiple point mutations on the cDNA of PERP in A549, H1299 and CL1-0 lung cancer cell lines as well as lung cancer tissues. Among them, C428G m

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