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Dissertations / Theses on the topic 'Pab1'

Author: Grafiati
Published: 9 March 2023
Last updated: 31 July 2025

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1

BRAMBILLA, MARCO. "Rewiring yeast nitrogen and mRNA metabolism for eliciting industrially relevant phenotypes. The Saccharomyces cerevisiae glutamate synthase (Glt1) and the poly(A) binding protein (Pab1) as case studies." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/198932.

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Le attuali produzioni di energia e materiali si basano soprattutto sullo sfruttamento di fonti fossili, ma la loro non rinnovabilità e la necessità di una maggiore sostenibilità ambientale han contribuito ad aumentare l’interesse verso risorse alternative. In questo contesto si collocano le bioraffinerie, che sono volte alla conversione di biomasse rinnovabili in prodotti commerciabili. Per implementare bioindustrie competitive, molte sfide devono essere superate, tra cui il miglioramento delle prestazioni dei microrganismi, cell factory, utilizzati nei processi produttivi. Tra tutte, il lievi
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Grenier, St-Sauveur Valérie. "Caractérisation et fonction de la protéine Nab2 chez Schizosaccharomyces pombe." Mémoire, Université de Sherbrooke, 2014. http://savoirs.usherbrooke.ca/handle/11143/105.

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L’étude qui vous est présentée dans ce mémoire est réalisée chez l’organisme Schizosaccharomyces pombe et elle porte sur la caractérisation de la protéine Nab2, une protéine liant les queues poly(A) ainsi que sur son implication dans la régulation génique. Tout d’abord, il faut savoir qu’il existe quatre modes de régulation (transcriptionnel, post-transcriptionnel, traductionnel et post-traductionnel) dans lesquels interviennent différents types de protéines, en particulier des protéines liant les queues poly(A) des ARN, aussi connues sous le nom de PABPs. Ces protéines reconnaissent l’ARN à
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Grenier, St-Sauveur Val??rie. "Caract??risation et fonction de la prot??ine Nab2 chez Schizosaccharomyces pombe." Mémoire, Universit?? de Sherbrooke, 2014. http://savoirs.usherbrooke.ca/handle/11143/105.

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L?????tude qui vous est pr??sent??e dans ce m??moire est r??alis??e chez l???organisme Schizosaccharomyces pombe et elle porte sur la caract??risation de la prot??ine Nab2, une prot??ine liant les queues poly(A) ainsi que sur son implication dans la r??gulation g??nique. Tout d???abord, il faut savoir qu???il existe quatre modes de r??gulation (transcriptionnel, post-transcriptionnel, traductionnel et post-traductionnel) dans lesquels interviennent diff??rents types de prot??ines, en particulier des prot??ines liant les queues poly(A) des ARN, aussi connues sous le nom de PABPs. Ces prot??ine
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Penheiter, Kristi L. "Functional characterization of the Paf1 complex in Saccharomyces cerevisiae by identification of Paf1 target genes /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Molecular Biology) -- University of Colorado at Denver and Health Sciences Center, 2005.<br>Typescript. Includes bibliographical references (leaves 126-149). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
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de, Carli da Costa Lima Tamara. "Caracterização funcional de homólogos à proteína de ligação a Cauda Poli-A (PABP) de Leishmania major." Universidade Federal de Pernambuco, 2007. https://repositorio.ufpe.br/handle/123456789/6362.

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Made available in DSpace on 2014-06-12T18:04:28Z (GMT). No. of bitstreams: 2 arquivo6197_1.pdf: 1859004 bytes, checksum: e86e2d8c963670c51f4e1b8266e440a2 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2007<br>A proteína de ligação à cauda poli-A (PABP) se liga a seqüência de poli adenosinas presente na extremidade 3 do mRNA e possui uma multiplicidade de funções dentro da célula. Dentre as funções atribuídas a PABP destaca-se sua participação em eventos da síntese de proteínas, tais como iniciação e terminação da tradução e reciclage
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Siddiqui, Nadeem. "Structure and function of the PABC domain." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102727.

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The poly (A)-binding protein (PABP) is an essential protein found in all eukaryotes and functions in mRNA metabolic and translational processes. Structurally, PABP consists of two distinct regions. The N-terminal half contains four RNA recognition motifs that bind to the poly (A)-tail of mRNA, while the C-terminal segment contains a unique peptide binding module referred to as the PABC domain. The function of this domain in PABP is to recruit proteins containing a very specific 'PAM-2' motif to the mRNP complex. Unique to metazoans, a PABC domain is also found in the hyperplastic discs tumor s
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Angathevar, Veluchamy Raaja Raajan. "Structure and activity of Pseudomonas aeruginosa PAO1 biofilms." Thesis, Montana State University, 2006. http://etd.lib.montana.edu/etd/2006/angathevarveluchamy/AngathevarVeluchamyR0506.pdf.

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Roy, Guylaine. "Characterization of PABP-interacting proteins 1 and 2." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84317.

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The 3' poly(A) tail of eukaryotic mRNAs and the poly(A) binding protein (PABP) play key roles in the regulation of translation. Recently, our group identified two human PABP-interacting proteins (Paip), Paip1 and Paip2, which stimulate and repress translation, respectively. Paip2 also inhibits the binding of PABP to the poly(A) tail and competes with Paip1 for binding to PABP. My research project was divided into two parts to allow me to gain a greater understanding of the roles of these two PABP-interacting proteins. First, in order to study the mechanism of interaction of Paip1 and PA
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Fantus, Daniel. "The polyadenlyate binding protein (PABP) and translational control /." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80261.

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Translation is the process by which proteins are synthesized from messenger RNAs. This complex process is regulated by a multitude of factors (1). One such factor is the Polyadenylate Binding Protein (PABP), an abundant protein associated with messenger ribonucleoprotein particles (mRNPs) (18). As a result of its interaction with both poly(A) RNA and eukaryotic initiation factor 4G (eIF4G), a component of the tripartite eIF4F cap-binding complex, PABP elicits mRNA circularization and stimulates translation (2). Although the mechanism by which mRNA circularization facilitates translation
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楊雋永 and Chun-wing Yeung. "PAK1, PAK2 and PAK4 in gestational trophoblastic disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40721905.

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Price, Bianca Louise. "Characterisation of rhamnolipid biosynthesis in Pseudomonas aeruginosa PA01." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609565.

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El, Bestawy Walid. "Transcriptional regulation of the mouse PAC1 receptor gene." Thesis, University of Strathclyde, 2013. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=22708.

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The G-protein coupled receptor PAC1 has been implicated in playing a role in neural growth, development and stress-protection, cognition, homeostasis, immunomodulation and anti-inflammatory effects. Previously, an investigation of PAC1 gene (mADCYAP1r1) revealed a minimum promoter region -113bp to +206 relative to the transcriptional start site. Binding of the Zac1 transcription factor has been investigated but no detailed analysis has been carried out of the region downstream or upstream of -2598bp from exon 1 and a full characterisation of the Transcription Factors (TF) that govern expressio
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Nelson, Shona Margaret. "Studies on biofilm growth of Pseudomonas aeruginosa PA01." Thesis, Aston University, 1993. http://publications.aston.ac.uk/12581/.

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The development of in vitro techniques to model the surface-associated mode of growth is a prerequisite to understanding more fully the physiological changes involved in such a growth strategy. Key factors believed to influence bacterial persistence in chronic infections are those of the biofilm mode of growth and slow growth rate. Methods for controlling Pseudomonas aeruginosa biofilm population growth rates were investigated in this project. This microorganism was incompatible with the in vitro 47mm diameter membrane filter-based biofilm technique developed for the study of Escherichia coli
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Yeung, Chun-wing. "PAK1, PAK2 and PAK4 in gestational trophoblastic disease." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40721905.

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Smith, Stephen. "The regulation and role of PAK1 in macrophages." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445920/.

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The p21-activated kinases (PAKs) are a family of serine/threonine kinases that are activated by the Rho GTPases, Rac1-3, Cdc42, Chp, TC10 and Wrch-1, as well as a number of lipids and PAK-interacting proteins. PAKs have been implicated in a variety of cellular processes including cell polarisation, migration, chemotaxis and gene transcription. The aim of this study was to determine the regulation and function of PAK1, using bone marrow-derived macrophages (BMMs) as a model system. CSF-1 stimulation of BMMs induced rapid phosphorylation and activation of PAK1, and CSF-1 and TNFa also promoted a
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Tsui, Hoyee. "The role of p21-activated kinase 1 (Pak1) in the heart." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-p21activated-kinase-1-pak1-in-the-heart(8c34d7bc-a2aa-4ae0-a197-91ed905212f5).html.

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Heart failure is associated with a high mortality rate and is one of the most prevalent diseases worldwide whereby susceptibility increases with age. The development of heart failure occurs over an extensive period of time in which arrhythmias and hypertrophy are both very prevalent manifestations throughout this progression. Arrhythmias are defined as an irregular rhythm originating from intracellular calcium dysregulation, which can be fatal. Cardiac hypertrophy is a compensatory condition induced by increased workload involving augmented cardiomyocyte growth accompanied by myocardial remode
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Ganem, Carine. "Implication de Cak1 (CDK activating kinase) dans le processus de transcription par l'ARN polymérase II chez Saccharomyces cerevisiae." Paris 11, 2002. http://www.theses.fr/2002PA112180.

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Chez la levure S. Cerevisiae, les rôles physiologiques connus de la protéine essentielle Cak1 (kinase activatrice des kinases cycline-dépendantes (CDK)) sont de phosphoryler Cdc28, régulateur majeur du cycle cellulaire, ainsi que Kin28, kinase du domaine carboxy-terminal de la plus grosse sous-unité de l'ARN polymérase II. Des mutants conditionnels de cakI semblent affectés dans le contrôle du cycle cellulaire, mais aussi dans la formation de la paroi des spores, la différentiation pseudohyphale, ainsi que dans la réponse au stress osmotique. Dans ce travail, nous avons montré que Cak1 est imp
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St-André, Olivier. "La régulation des gènes méiotiques par la protéine PAB2." Mémoire, Université de Sherbrooke, 2011. http://hdl.handle.net/11143/5567.

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Les travaux décrits dans ce mémoire visent à élucider le rôle de la protéine Pab2 dans la régulation des gènes méiotiques. La méiose est un phénomène conservé à travers l'évolution chez les organismes eucaryotes. Chez les eucaryotes unicellulaires comme la levure, la méiose accomplie [i.e. accomplit] autant un rôle de reproduction sexuelle qu'un rôle de protection de l'organisme. Chez la levure à fission Schizosaccharomyces pombe , le processus de méiose résultant de la reproduction de deux individus génère des spores, des structures résistantes aux conditions environnementales détrimentales.
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Chapman, Tajekesa Kudzaishe Pamacheche. "Regulation of PABP1 function by differential post-translational modification." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25875.

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Post-transcriptional control of gene expression is critical for normal cellular function and viability. Poly(A)-binding protein (PABP) 1 is the prototypical member of a family of RNA-binding proteins which are key post-transcriptional regulators. PABP1 is multifunctional, acting as a primary determinant of translation efficiency and mRNA stability, regulating the fate of specific mRNAs, and participating in microRNAmediated regulation and nonsense-mediated mRNA decay. As well as binding various mRNAs, PABP1 achieves its multifunctionality through protein-protein interactions with numerous PABP
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Rasselet, Damien. "Etude de nanocomposites basés sur des alliages PLA/PA11." Thesis, IMT Mines Alès, 2019. http://www.theses.fr/2019EMAL0001/document.

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L’acide polylactique (PLA) est l’un des polymères biosourcés qui suscite le plus d’intérêt, mais ses propriétés thermomécaniques nécessitent d’être améliorées. Pour ce faire, les méthodes les plus utilisées et étudiées sont de le mélanger avec d’autres polymères ou bien d’y ajouter des charges minérales nanométriques (nanoparticules), afin de constituer un nanocomposite à matrice PLA. C’est dans la combinaison de ces deux approches que s’inscrivent ces travaux de thèse, consacrés à l’élaboration et à la caractérisation des propriétés de nanocomposites à base d’un alliage de PLA et de polyamide
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SCELLES, VERONIQUE. "Inhibiteur de l'activateur du plasminogene (pai1) et maladies metaboliques." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20837.

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Harb, Maya. "Effet de l'interaction de la protéine NSP3 du Rotavirus avec les protéines cellulaires, eIF4G et RoXaN, sur la localisation subcellulaire de PABP." Paris 11, 2008. http://www.theses.fr/2008PA114848.

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La protéine non structurale du Rotavirus, NSP3, interagit avec l’extrémité 3’ des ARNm viraux, avec le facteur d’initiation de la traduction eIF4G, ainsi qu’avec la protéine cellulaire RoXaN. NSP3, en se fixant à l’eIF4G décroche la poly(A) binding protein cytoplasmique (PABPC1) du complexe d’initiation de la traduction, et empêche ainsi l’initiation de la traduction des ARNm cellulaires. De cette façon, la traduction des ARNm viraux est favorisée. Ce travail avait pour objet l’étude du rôle de l’interaction de NSP3 avec RoXaN dont la fonction était jusqu’alors inconnue. Dans une première part
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Langley, Roger Sean. "Metal binding by Pseudomonas aeruginosa PAO1 and isogenic lipopolysaccharide mutants." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ33244.pdf.

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Landreau, Emmanuel. "Matériaux issus de ressources renouvelables. Mélanges amidon plastifié/PA11 compatibilisés." Reims, 2008. http://theses.univ-reims.fr/exl-doc/GED00000801.pdf.

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Pour développer un matériau issu de ressources renouvelables, l'amidon plastifié a donc été mélangé au polyamide 11, issu de l'huile de ricin, dans le but d'améliorer ses propriétés mécaniques et sa résistance à l'eau. Malgré la forte polarité des liaisons amide, le mélange a besoin d'être compatibilisé. Les différents compatibisants étudiés sont des polysaccharides anioniques susceptibles de développer des interactions avec le polyamide et l'amidon: alginate de sodium, carraghenane et carboxymethylcellulose. Des tests en mélangeur interne montrent que seule la carboxyméthylcellulose (CMC) per
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Landreau, Emmanuel Tighzert Lan Bliard Christophe. "Matériaux issus de ressources renouvelables. Mélanges amidon plastifié/PA11 compatibilisés." Reims : S.C.D. de l'Université, 2008. http://scdurca.univ-reims.fr/exl-doc/GED00000801.pdf.

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Alsayegh, Maha. "DEF6 is associated with the translational initiation regulating protein synthesis of eIF4E, 4E-T and PABP and colocalises with eIF4E and PABP in the immunological synapse." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/51984/.

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DEF6 is an atypical guanine nucleotide exchange factor (GEF) for Rho GTPases Rac1 and Cdc42, which is highly expressed in mature T cells. DEF6 is recruited to the immunological synapse (IS) following phosphorylation by LCK in response to T cell receptor (TCR) stimulation during inflammation. In resting Jurkat T cells, DEF6 has been known to associate with polysomes and under cellular stress conditions to form cytoplasmic granules colocalising with mRNA decapping enzyme subunit 1 (DCP1), a marker of P-bodies. Hence DEF6 has been linked to mRNA regulation, which includes mRNA translation initiat
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Löfgren, Emma. "The role of PAR1 and PAR4 in platelet PAI-1 secretion." Thesis, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20813.

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<p>In Sweden about 26000 people are affected by myocardial infarction (MI) every year. Coronary vascular diseases and cerebrovascular diseases with blood flow disruption caused by thrombi are actually the most common cause of death. A contributing mechanism may be if the fibrinolytic system is uncapable to dissolve clots and it might in turn be related to the high amount of plasminogen activator inhibitor 1 (PAI-1) released from platelets. This study investigated if there is any difference between the thrombin activation of the platelet protease activated receptors (PAR) PAR1 and PAR4 concerni
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Yang, Zhe. "Functional Characterization of the Arginine Transaminase Pathway in Pseudomonas aeruginosa PAO1." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/biology_diss/29.

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Arginine utilization in Pseudomonas aeruginosa with multiple catabolic pathways represents one of the best examples of metabolic versatility of this organism. To identify genes of this complex arginine network, we employed DNA microarray to analyze the transcriptional profiles of this organism in response to L-arginine. While most genes in arginine uptake, regulation and metabolism have been identified as members of the ArgR regulon in our previous study, eighteen putative transcriptional units of 38 genes including the two known genes of the arginine dehydrogenase (ADH) pathway, kauB and gbuA
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Wang, Xiaoqi. "Role of the PAT1 gene of S. cerevisiae in genome stability." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389018.

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Derbali, Habib. "La caractérisation de l'amidotransférase ARNt-dépendante (AdT) de Pseudomonas aeruginosa PA01." Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25218/25218.pdf.

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Penney, Mary. "Pad1 : a novel subunit of the 26S proteasome in fission yeast." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/11250.

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Mutations in the fission yeast genes mts5-1 and mbc]-1 were isolated in a screen for Schizosaccharomyces pombe (S.pombe) mutants that are both resistant to the microtubule destabilising drug methybenzylcarbamylate (MBCR) and temperature sensitive (t.s.) for growth. This screen has so far been specific for mutations in genes encoding subunits of the 26S proteasome (Gordon et al., 1993). This study shows that these strains contain mutations in the pad1 and crm] genes respectively. Crm] and pad] have previously been shown to be positive and negative regulators respectively of the AP-1 transcripti
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Briand, Stéphanie. "APP, PAT1, SET et mort neuronale : implications dans la Maladie d'Alzheimer." Paris 6, 2011. http://www.theses.fr/2011PA066012.

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La Maladie d’Alzheimer est une affection à neurodégénérescence importante qui comporte des plaques amyloïdes et des dégénérescences neurofibrillaires (DNFs). Les plaques sont majoritairement composées de peptide Aβ issu de la protéine APP. Les DNFs sont une agrégation de la protéine Tau hyperphosphorylée en filaments insolubles. Dans les neurones, l’accumulation du domaine cytoplasmique de l’APP allant de la membrane au site caspase (Jcasp) induit une apoptose in vitro et in vivo. Dans ce modèle comme en pathologie la protéine SET, impliquée dans la phosphorylation de Tau, se délocalise du noy
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Derbali, Habib. "La caractérisation de l'amidotransférase ARNt-dépendante (AdT) de Pseudomonas aeruginosa PAO1." Master's thesis, Université Laval, 2008. http://hdl.handle.net/20.500.11794/19806.

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Eyraud, Vanessa. "Etude d’un insecticide naturel nommé PA1b : Mécanisme d’action et expression hétérologue." Thesis, Lyon, INSA, 2014. http://www.theses.fr/2014ISAL0020/document.

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Dans un contexte où l’utilisation de substance chimique en agriculture est de plus en plus décriée, il est nécessaire de trouver de nouveaux moyens de protections des cultures, tout en maintenant une agriculture économiquement performante. Ainsi, un peptide extrait de graines de pois nommée PA1b (Pea Albumin 1 sous-unité b), présentant une forte activité insecticide a été découvert au laboratoire. PA1b provoque chez l’insecte modèle du laboratoire, le charançon des céréales Sitophilus sp., 100% de mortalité. L’action de PA1b passe par la liaison à un récepteur présent chez les charançons sensi
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El, Atmani Asmaa. "Implication de PAR1 dans la progression du cancer de la prostate." Thesis, Paris Est, 2009. http://www.theses.fr/2009PEST0047.

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Le phénomène métastatique est important à comprendre puisque de manière irrémédiable, une fois engagé, il conduit le plus souvent au décès des patients. Le cancer de la prostate représente un bon modèle car sa progression du stade hormono-dépendant vers le stade d'hormono-échappement s’accompagne par l’apparition de métastases. Les Protease Activated Receptors (PAR1-4) sont des récepteurs qui jouent un rôle important dans l'hémostase et l'inflammation et dont l’implication dans la prolifération et l'invasion des cellules tumorales a été décrite dans plusieurs tissus. L’étude comparative de l'e
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Lévêque, Maxime. "Évaluation du potentiel d’un polymère bio-sourcé, PA11, pour applications piézoélectriques." Thesis, Lille 1, 2014. http://www.theses.fr/2014LIL10194.

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Les développements récents des applications d’électronique portable demande de plus en plus l’utilisation de systèmes de récupération d’énergie à partir de sources environnantes de basse énergie. La conversion piézoélectrique à partir de sources vibratoire pourrait être un moyen intéressant pour l’alimentation électrique de petits systèmes. Dans ce travail, nous investiguons les potentialités de films de polymère bio-sourcé à base de polyamide 11 (PA11). Dans un premier temps, les effets de traitements physiques ou chimiques sur le développement des phases cristallines du PA11 ont été longueme
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Abreu, Ieda Santos. "Influência do diabetes mellitus do tipo 2 na expressão dos receptores ativados por protease do tipo 1 (PAR1) e do tipo 2 (PAR2) em pacientes com periodontite crônica." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/23/23146/tde-18032015-161437/.

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O receptor ativado por protease do tipo 1 (PAR1) parece estar associado ao reparo periodontal, enquanto o tipo 2 (PAR2) com a inflamação periodontal. Esses receptores podem ser ativados pelas proteases gingipaina, uma protease secretada pela Porphyromonas gingivalis, um importante periodontopatógeno, e pela proteinase-3 de neutrófilos (P3), que é liberada por neutrófilos quando expostos a um estímulo inflamatório. Uma vez que o diabetes é reconhecido como um fator de risco importante para a doença periodontal, o objetivo deste estudo foi investigar a expressão de PAR1 e de PAR2 e de seus ativa
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Bruneau, Joannie. "Gata4 et Cdx2 sont des régulateurs transcriptionnels intestinaux du gène encodant la protéine sécrétoire de type lectine Pap1." Mémoire, Université de Sherbrooke, 2011. http://hdl.handle.net/11143/5542.

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Gata4 est un facteur de transcription exprimé par les entérocytes. Nos études ont démontré que Gata4 pouvait réguler l'expression de Pap1 chez le rat. Ce gène encode pour une protéine sécrétoire de type lectine impliquée dans le contrôle de la prolifération bactérienne. Puisqu'il a été démontré que des lectines antibactériennes de la famille Pap sont sécrétées dans la lumière intestinale en réponse à des stimuli inflammatoires, le but de cette étude était de définir l'implication transcriptionnelle de Gata4 dans la réponse inflammatoire des cellules épithéliales intestinales. Afin de caractéri
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Kwok, Yuen-yuen. "Cloning and characterization of PAC1 receptor splice variants in goldfish (Carassius auratus)." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B30708072.

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Haglund, Linda. "Thrombin receptor signalling in platelets: PAR1, but not PAR4, is rapidly desensitized." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18455.

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<p> </p><p>Platelets play a key role in primary haemostasis but are also related to the pathogenesis of arterial thrombosis. Thrombin is the most effective agonist inducing platelet activation. Human platelets express two G-protein coupled thrombin receptors (GPCRs), called protease activated receptor (PAR)1 and PAR4. The aim of this study was to clarify differences in the activities of PAR1 and PAR4, especially focusing on their resistance towards the platelet inhibitor nitric oxide (NO) and their ability to undergo desensitization. For this, PAR1- and PAR4- activating peptides (APs) (SFLLRN
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41

Chou, Han Ting. "L-Lysine Decarboxylase and Cadaverine Gamma-Glutamylation Pathways in Pseudomonas Aeruginosa PAO1." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/biology_diss/103.

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In comparison to other Pseudomonas, P. aeruginosa grows poorly in L-lysine as a sole source of nutrient while fast growth mutants can be obtained. The proposed catabolic pathway involves lysine decarboxylation to cadaverine and its subsequent degradation through g-glutamylation pathway to d-aminovalerate and glutarate. The lysine decarboxylase A (ldcA) gene, previously identified as a member of the ArgR regulon of L-arginine metabolism, was found essential for L-lysine catabolism. The ldcA gene encodes a decarboxylase which takes L-lysine but not L-arginine as substrate. Contrarily, the ldcA e
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Taverner, Claire Jeanne. "Regulation of proliferation and cell survival by thrombin through the PAR1 receptor." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620458.

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Kwok, Yuen-yuen, and 郭圓圓. "Cloning and characterization of PAC1 receptor splice variants in goldfish (Carassius auratus)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30708072.

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44

Vretenbrant, Öberg Karin. "The role of platelet thrombin receptors PAR1 and PAR4 in platelet activation." Doctoral thesis, Linköpings universitet, Klinisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51935.

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Platelets play a pivotal role in coagulation and haemostasis. Their most prominent task is to seal damaged blood vessels by the formation of a platelet plug at the damaged area. Once the injury is covered, platelets retract the coagulum to close the wound and allow the blood to flow freely in the vessel. Platelets are strongly activated by the essential enzyme thrombin, formed in the coagulation cascade. Activation of the platelet thrombin receptors PAR1 and PAR4 leads to shape change, secretion of granule content, and aggregation, all of which can be accomplished by each receptor individually
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Marnef, Aline. "Investigating the roles of Pat1 proteins in the control of gene expression." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610150.

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Davis, Hannah E. "The role of the pak1 protein kinase in fission yeast cell polarity." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/13592.

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p21-activated kinase (paklp) is essential in fission yeast and plays roles in cell polarity and mating. The <i>pakl-34 </i>mutant has a specific mutation that does not affect essential functions but causes highly penetrant defects in cell polarity and morphology. The <i>pakl-34 </i>strain has a specific defect in bipolar growth and the potential to help dissect the role of paklp in mediating cell polarity. Tagging experiments demonstrated that both wild type and pakl-34 proteins localize to cell tips and septa. I hypothesised that pak-34p may be deficient in kinase activity. I adapted a two-di
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Rabelo, Jacilane de Holanda. "Pabc-pattern: uma estratégia para codificar lições aprendidas em organizações de software." Universidade Federal do Amazonas, 2013. http://tede.ufam.edu.br/handle/tede/2929.

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Made available in DSpace on 2015-04-11T14:03:00Z (GMT). No. of bitstreams: 1 Jacilane de Holanda Rabelo.pdf: 4788725 bytes, checksum: 199f5b959e361201af68d3afa0ac710f (MD5) Previous issue date: 2013-02-19<br>CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The knowledge acquired by the members of a software organization is one of its most important assets. Therefore, the proper management of this knowledge has become a real need in the software development industry. The capture of lessons learned has become a practice developed by some of these organizations in order
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Abdel-Malek, Suzanne Mohamed Amin. "Studies on the mechanism of zinc pyrithione resistance in Pseudomonas aeruginosa PAO1." Thesis, Abertay University, 2002. https://rke.abertay.ac.uk/en/studentTheses/9dedb4be-5764-4460-993b-67553e8075fb.

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Previous workers have suggested that it is possible to passage <i>Pseudomonas aeruginosa</i> towards resistance against selected antimicrobial agents (Isothiazolone biocides). These passages in sub-minimal inhibitory concentrations (sub-MIC) of antimicrobial agents also exhibited corresponding shifts in outer membrane protein profiles. The aim of this project was to elucidate whether or not such adaptive resistance was evidenced with consecutive passages in sub-MIC of the Pyrithione group of antimicrobial agents and whether or not such passages yielded comparable outer membrane protein shifts.
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Seo, Young Hoon. "Purification and characterization of pyocin S2 : bacteriocin produced by Pseudomonas aeruginosa PA01 /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487688973686079.

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NASCIMENTO, JUNIOR Agrinaldo Jacinto do. "A Influência de Cátions na Membrana de Lipopolissacarídeos de Pseudomonas aeruginosa PAO1." Universidade Federal de Pernambuco, 2013. https://repositorio.ufpe.br/handle/123456789/12203.

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Submitted by Etelvina Domingos (etelvina.domingos@ufpe.br) on 2015-03-12T16:57:48Z No. of bitstreams: 2 TESE_Agrinaldo Jacinto do Nascimento Júnior.pdf: 6927683 bytes, checksum: bf123d71858e87a718a988da950251f3 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5)<br>Made available in DSpace on 2015-03-12T16:57:48Z (GMT). No. of bitstreams: 2 TESE_Agrinaldo Jacinto do Nascimento Júnior.pdf: 6927683 bytes, checksum: bf123d71858e87a718a988da950251f3 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2013-12-19<br
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