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Journal articles on the topic 'Pab1'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Ardelean, Radu, Adriana Popa, Ecaterina Stela Drăgan, Corneliu-Mircea Davidescu, and Maria Ignat. "New Polymeric Adsorbents Functionalized with Aminobenzoic Groups for the Removal of Residual Antibiotics." Molecules 27, no. 9 (2022): 2894. http://dx.doi.org/10.3390/molecules27092894.

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In this paper, we present the synthesis of new polymeric adsorbents derived from macroporous chloromethylated styrene–divinylbenzene (DVB) copolymers with different cross-linking degrees functionalized with the following aminobenzoic groups: styrene—6.7% DVB (PAB1), styrene—10% DVB (PAB2), and styrene—15% DVB (PAB3). The new polymeric products, PAB1, PAB2, and PAB3, were characterized by FTIR spectroscopy, thermogravimetric analysis, and EDX, SEM, and BET analysis, respectively. The evolution of the functionalization reaction was followed by FTIR spectroscopy, which revealed a decrease in the

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Amirkhosravi, Ali, Todd V. Meyer, Liza Robles-Carrillo та ін. "β2-Glycoprotein 1 Antibodies Directly Activate the Platelet IgG Receptor, FcγRIIa, and Cause Thrombosis in FCGR2A Transgenic but Not in Wild Type Mice". Blood 120, № 21 (2012): 106. http://dx.doi.org/10.1182/blood.v120.21.106.106.

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Abstract Abstract 106 Antibodies targeting β2-glycoprotein 1 (β2-GP1; β2-Abs) are of primary importance in antiphospholipid syndrome (APS), a thrombotic autoimmune disorder. The predominance of the IgG antibody isotype in APS is conspicuously associated with increased risk of thrombosis, raising the question whether the platelet IgG receptor, FcγRIIa, may play a role in thrombosis in APS, as is the case in heparin-induced thrombocytopenia (HIT). The hypothesis that platelet FcγRIIa may contribute to thrombosis in APS has received little attention, with research emphasis instead placed on sever

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Mangus, David A., Nadia Amrani, and Allan Jacobson. "Pbp1p, a Factor Interacting withSaccharomyces cerevisiae Poly(A)-Binding Protein, Regulates Polyadenylation." Molecular and Cellular Biology 18, no. 12 (1998): 7383–96. http://dx.doi.org/10.1128/mcb.18.12.7383.

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ABSTRACT The poly(A) tail of an mRNA is believed to influence the initiation of translation, and the rate at which the poly(A) tail is removed is thought to determine how fast an mRNA is degraded. One key factor associated with this 3′-end structure is the poly(A)-binding protein (Pab1p) encoded by the PAB1 gene inSaccharomyces cerevisiae. In an effort to learn more about the functional role of this protein, we used a two-hybrid screen to determine the factor(s) with which it interacts. We identified five genes encoding factors that specifically interact with the carboxy terminus of Pab1p. Of

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Mangkalaphiban, Kotchaphorn, Robin Ganesan, and Allan Jacobson. "Pleiotropic effects of PAB1 deletion: Extensive changes in the yeast proteome, transcriptome, and translatome." PLOS Genetics 20, no. 9 (2024): e1011392. http://dx.doi.org/10.1371/journal.pgen.1011392.

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Cytoplasmic poly(A)-binding protein (PABPC; Pab1 in yeast) is thought to be involved in multiple steps of post-transcriptional control, including translation initiation, translation termination, and mRNA decay. To understand both the direct and indirect roles of PABPC in more detail, we have employed mass spectrometry to assess the abundance of the components of the yeast proteome, as well as RNA-Seq and Ribo-Seq to analyze changes in the abundance and translation of the yeast transcriptome, in cells lacking the PAB1 gene. We find that pab1Δ cells manifest drastic changes in the proteome and t

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Dufresne, Philippe J., Eliane Ubalijoro, Marc G. Fortin, and Jean-François Laliberté. "Arabidopsis thaliana class II poly(A)-binding proteins are required for efficient multiplication of turnip mosaic virus." Journal of General Virology 89, no. 9 (2008): 2339–48. http://dx.doi.org/10.1099/vir.0.2008/002139-0.

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The poly(A)-binding protein (PABP) is an important translation initiation factor that binds to the polyadenylated 3′ end of mRNA. We have previously shown that PABP2 interacts with the RNA-dependent RNA polymerase (RdRp) and VPg-Pro of turnip mosaic virus (TuMV) within virus-induced vesicles. At least eight PABP isoforms are produced in Arabidopsis thaliana, three of which (PABP2, PABP4 and PABP8) are highly and broadly expressed and probably constitute the bulk of PABP required for cellular functions. Upon TuMV infection, an increase in protein and mRNA expression from PAB2, PAB4 and PAB8 gen

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Yao, Gang, Yueh-Chin Chiang, Chongxu Zhang, Darren J. Lee, Thomas M. Laue, and Clyde L. Denis. "PAB1 Self-Association Precludes Its Binding to Poly(A), Thereby Accelerating CCR4 Deadenylation In Vivo." Molecular and Cellular Biology 27, no. 17 (2007): 6243–53. http://dx.doi.org/10.1128/mcb.00734-07.

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ABSTRACT The mRNA deadenylation process, catalyzed by the CCR4 deadenylase, is known to be the major factor controlling mRNA decay rates in Saccharomyces cerevisiae. We have identified the proline-rich region and RRM1 domains of poly(A) binding protein (PAB1) as necessary for CCR4 deadenylation. Deletion of either of these regions but not other regions of PAB1 significantly reduced PAB1-PAB1 protein interactions, suggesting that PAB1 oligomerization is a required step for deadenylation. Moreover, defects in these two regions inhibited the formation of a novel, circular monomeric PAB1 species t

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Amrani, N., M. Minet, M. Le Gouar, F. Lacroute, and F. Wyers. "Yeast Pab1 interacts with Rna15 and participates in the control of the poly(A) tail length in vitro." Molecular and Cellular Biology 17, no. 7 (1997): 3694–701. http://dx.doi.org/10.1128/mcb.17.7.3694.

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In Saccharomyces cerevisiae, the single poly(A) binding protein, Pab1, is the major ribonucleoprotein associated with the poly(A) tails of mRNAs in both the nucleus and the cytoplasm. We found that Pab1 interacts with Rna15 in two-hybrid assays and in coimmunoprecipitation experiments. Overexpression of PAB1 partially but specifically suppressed the rna15-2 mutation in vivo. RNA15 codes for a component of the cleavage and polyadenylation factor CF I, one of the four factors needed for pre-mRNA 3'-end processing. We show that Pab1 and CF I copurify in anion-exchange chromatography. These data s

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Konopka, Catherine A., Melissa N. Locke, Pamela S. Gallagher, et al. "A yeast model for polyalanine-expansion aggregation and toxicity." Molecular Biology of the Cell 22, no. 12 (2011): 1971–84. http://dx.doi.org/10.1091/mbc.e11-01-0037.

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Nine human disorders result from the toxic accumulation and aggregation of proteins with expansions in their endogenous polyalanine (polyA) tracts. Given the prevalence of polyA tracts in eukaryotic proteomes, we wanted to understand the generality of polyA-expansion cytotoxicity by using yeast as a model organism. In our initial case, we expanded the polyA tract within the native yeast poly(Adenine)-binding protein Pab1 from 8A to 13A, 15A, 17A, and 20A. These expansions resulted in increasing formation of Pab1 inclusions, insolubility, and cytotoxicity that correlated with the length of the

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Anderson, J. T., M. R. Paddy, and M. S. Swanson. "PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae." Molecular and Cellular Biology 13, no. 10 (1993): 6102–13. http://dx.doi.org/10.1128/mcb.13.10.6102-6113.1993.

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Proteins that directly associate with nuclear polyadenylated RNAs, or heterogeneous nuclear RNA-binding proteins (hnRNPs), and those that associate with cytoplasmic mRNAs, or mRNA-binding proteins (mRNPs), play important roles in regulating gene expression at the posttranscriptional level. Previous work with a variety of eukaryotic cells has demonstrated that hnRNPs are localized predominantly within the nucleus whereas mRNPs are cytoplasmic. While studying proteins associated with polyadenylated RNAs in Saccharomyces cerevisiae, we discovered an abundant polyuridylate-binding protein, PUB1, w

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Anderson, J. T., M. R. Paddy, and M. S. Swanson. "PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae." Molecular and Cellular Biology 13, no. 10 (1993): 6102–13. http://dx.doi.org/10.1128/mcb.13.10.6102.

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Proteins that directly associate with nuclear polyadenylated RNAs, or heterogeneous nuclear RNA-binding proteins (hnRNPs), and those that associate with cytoplasmic mRNAs, or mRNA-binding proteins (mRNPs), play important roles in regulating gene expression at the posttranscriptional level. Previous work with a variety of eukaryotic cells has demonstrated that hnRNPs are localized predominantly within the nucleus whereas mRNPs are cytoplasmic. While studying proteins associated with polyadenylated RNAs in Saccharomyces cerevisiae, we discovered an abundant polyuridylate-binding protein, PUB1, w

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Cosson, Bertrand, Anne Couturier, Svetlana Chabelskaya, et al. "Poly(A)-Binding Protein Acts in Translation Termination via Eukaryotic Release Factor 3 Interaction and Does Not Influence [PSI+] Propagation." Molecular and Cellular Biology 22, no. 10 (2002): 3301–15. http://dx.doi.org/10.1128/mcb.22.10.3301-3315.2002.

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ABSTRACT Recent studies of translational control suggest that translation termination may not be simply the end of synthesizing a protein but rather be involved in modulating both the translation efficiency and stability of a given transcript. Using recombinant eukaryotic release factor 3 (eRF3) and cellular extracts, we have shown for Saccharomyces cerevisiae that yeast eRF3 and Pab1p can interact. This interaction, mediated by the N+M domain of eRF3 and amino acids 473 to 577 of Pab1p, was demonstrated to be direct by the two-hybrid approach. We confirmed that a genetic interaction exists be

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Kobayashi, Tetsuo, Yuji Funakoshi, Shin-ichi Hoshino, and Toshiaki Katada. "The GTP-binding Release Factor eRF3 as a Key Mediator Coupling Translation Termination to mRNA Decay." Journal of Biological Chemistry 279, no. 44 (2004): 45693–700. http://dx.doi.org/10.1074/jbc.m405163200.

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GTP is essential for eukaryotic translation termination, where the release factor 3 (eRF3) complexed with eRF1 is involved as the guanine nucleotide-binding protein. In addition, eRF3 regulates the termination-coupled events, eRF3 interacts with poly(A)-binding protein (Pab1) and the surveillance factor Upf1 to mediate normal and nonsense-mediated mRNA decay. However, the roles of GTP binding to eRF3 in these processes remain largely unknown. Here, we showed in yeast that GTP is essentially required for the association of eRF3 with eRF1, but not with Pab1 and Upf1. A mutation in the GTP-bindin

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Wyers, Françoise, Michèle Minet, Marie Elisabeth Dufour, Le Thuy Anh Vo, and François Lacroute. "Deletion of the PAT1 Gene Affects Translation Initiation and Suppresses a PAB1 Gene Deletion in Yeast." Molecular and Cellular Biology 20, no. 10 (2000): 3538–49. http://dx.doi.org/10.1128/mcb.20.10.3538-3549.2000.

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ABSTRACT The yeast poly(A) binding protein Pab1p mediates the interactions between the 5′ cap structure and the 3′ poly(A) tail of mRNA, whose structures synergistically activate translation in vivo and in vitro. We found that deletion of the PAT1 (YCR077c) gene suppresses a PAB1 gene deletion and that Pat1p is required for the normal initiation of translation. A fraction of Pat1p cosediments with free 40S ribosomal subunits on sucrose gradients. ThePAT1 gene is not essential for viability, although disruption of the gene severely impairs translation initiation in vivo, resulting in the accumu

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Zhong, Guo-wei, Ping Jiang, Wei-ran Qiao, Yuan-wei Zhang, Wen-fan Wei, and Ling Lu. "Protein Phosphatase 2A (PP2A) Regulatory Subunits ParA and PabA Orchestrate Septation and Conidiation and Are Essential for PP2A Activity in Aspergillus nidulans." Eukaryotic Cell 13, no. 12 (2014): 1494–506. http://dx.doi.org/10.1128/ec.00201-14.

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ABSTRACTProtein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. Different activities of PP2A and subcellular localization are determined by its regulatory subunits. Here we identified and characterized the functions of two protein phosphatase regulatory subunit homologs, ParA and PabA, inAspergillus nidulans. Our results demonstrate that ParA localizes to the septum site and that deletion ofparAcauses hyperseptation, while overexpression ofparAabolishes septum formation; this suggests that ParA may function as a

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Brown, Justin T., Xianmei Yang, and Arlen W. Johnson. "Inhibition of mRNA Turnover in Yeast by an xrn1 Mutation Enhances the Requirement for eIF4E Binding to eIF4G and for Proper Capping of Transcripts by Ceg1p." Genetics 155, no. 1 (2000): 31–42. http://dx.doi.org/10.1093/genetics/155.1.31.

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Abstract Null mutants of XRN1, encoding the major cytoplasmic exoribonuclease in yeast, are viable but accumulate decapped, deadenylated transcripts. A screen for mutations synthetic lethal with xrn1Δ identified a mutation in CDC33, encoding eIF4E. This mutation (glutamate to glycine at position 72) affected a highly conserved residue involved in interaction with eIF4G. Synthetic lethality between xrn1 and cdc33 was not relieved by high-copy expression of eIF4G or by disruption of the yeast eIF4E binding protein Caf20p. High-copy expression of a mutant eIF4G defective for eIF4E binding resulte

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Wegkamp, Arno, Wietske van Oorschot, Willem M. de Vos, and Eddy J. Smid. "Characterization of the Role of para-Aminobenzoic Acid Biosynthesis in Folate Production by Lactococcus lactis." Applied and Environmental Microbiology 73, no. 8 (2007): 2673–81. http://dx.doi.org/10.1128/aem.02174-06.

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ABSTRACT The pab genes for para-aminobenzoic acid (pABA) biosynthesis in Lactococcus lactis were identified and characterized. In L. lactis NZ9000, only two of the three genes needed for pABA production were initially found. No gene coding for 4-amino-4-deoxychorismate lyase (pabC) was initially annotated, but detailed analysis revealed that pabC was fused with the 3′ end of the gene coding for chorismate synthetase component II (pabB). Therefore, we hypothesize that all three enzyme activities needed for pABA production are present in L. lactis, allowing for the production of pABA. Indeed, th

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Dunn, E. F. "Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export." Genes & Development 19, no. 1 (2005): 90–103. http://dx.doi.org/10.1101/gad.1267005.

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Kahan, Darren N., Ruofan Chen, Joshua Riback, Christopher Katanski, Allan Drummond, and Tobin R. Sosnick. "Molecular Factors Underlying Stress-Triggered Phase-Separation of Pab1." Biophysical Journal 116, no. 3 (2019): 350a. http://dx.doi.org/10.1016/j.bpj.2018.11.1903.

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WANG, HONG, LIJUN WANG, QINQIN HU, RONGHUI WANG, YANBIN LI, and MICHAEL KIDD. "Rapid and Sensitive Detection of Campylobacter jejuni in Poultry Products Using a Nanoparticle-Based Piezoelectric Immunosensor Integrated with Magnetic Immunoseparation." Journal of Food Protection 81, no. 8 (2018): 1321–30. http://dx.doi.org/10.4315/0362-028x.jfp-17-381.

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ABSTRACT Campylobacter jejuni is one of the leading causes of foodborne human gastrointestinal diseases. Poultry and poultry products have been identified as the major transmission routes to humans for this pathogenic bacterium. The objective of this research was to develop a rapid and sensitive immunosensor for detection of C. jejuni in poultry products on the basis of a quartz crystal microbalance (QCM) using magnetic nanobeads (MNBs) for separation of target pathogen and gold nanoparticles for amplification of the measurement. A QCM sensor in a flow cell was prepared by immobilizing the mou

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James, Timothy Y., Robert P. Boulianne, Alan P. F. Bottoli, José D. Granado, Markus Aebi, and Ursula Kües. "The pab1 gene of Coprinus cinereus encodes a bifunctional protein for para-aminobenzoic acid (PABA) synthesis: implications for the evolution of fused PABA synthases." Journal of Basic Microbiology 42, no. 2 (2002): 91. http://dx.doi.org/10.1002/1521-4028(200205)42:2<91::aid-jobm91>3.0.co;2-8.

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Pintard, Lionel, Dieter Kressler, and Bruno Lapeyre. "Spb1p Is a Yeast Nucleolar Protein Associated with Nop1p and Nop58p That Is Able To BindS-Adenosyl-l-Methionine In Vitro." Molecular and Cellular Biology 20, no. 4 (2000): 1370–81. http://dx.doi.org/10.1128/mcb.20.4.1370-1381.2000.

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ABSTRACT We present here the characterization of SPB1, an essential yeast gene that is required for ribosome synthesis. A cold-sensitive allele for that gene (referred to here asspb1-1) had been previously isolated as a suppressor of a mutation affecting the poly(A)-binding protein gene (PAB1) and a thermosensitive allele (referred to here asspb1-2) was isolated in a search for essential genes required for gene silencing in Saccharomyces cerevisiae. The two mutants are able to suppress the deletion of PAB1, and they both present a strong reduction in their 60S ribosomal subunit content. In an

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Padariya, Monikaben, and Umesh Kalathiya. "The Binding Specificity of PAB1 with Poly(A) mRNA, Regulated by Its Structural Folding." Biomedicines 10, no. 11 (2022): 2981. http://dx.doi.org/10.3390/biomedicines10112981.

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The poly(A)-binding protein cytoplasmic 1 (PAB1 or PABPC1) protein is associated with the long poly(A) mRNA tails, inducing stability. Herein, we investigated the dynamics of the PABPC1 protein, along with tracing its mRNA binding specificity. During molecular dynamics simulations (MDS), the R176-Y408 amino acids (RRM3–4 domains; RNA recognition motifs) initiated a folded structure that resulted in the formation of different conformations. The RRM4 domain formed high-frequency intramolecular interactions, despite such induced flexibility. Residues D45, Y54, Y56, N58, Q88, and N100 formed long-

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Le, Hanh, Su-Chih Chang, Robert L. Tanguay, and Daniel R. Gallie. "The Wheat Poly (A)-Binding Protein Functionally Complements Pab1 in Yeast." European Journal of Biochemistry 243, no. 1-2 (1997): 350–57. http://dx.doi.org/10.1111/j.1432-1033.1997.0350a.x.

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Zhang, Yirong, Linquan Bai, and Zixin Deng. "Functional characterization of the first two actinomycete 4-amino-4-deoxychorismate lyase genes." Microbiology 155, no. 7 (2009): 2450–59. http://dx.doi.org/10.1099/mic.0.026336-0.

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In some antibiotic producers, p-aminobenzoic acid (PABA) or its immediate precursor, 4-amino-4-deoxychorismate (ADC), is involved in primary metabolism and antibiotic biosynthesis. In Streptomyces sp. FR-008, a gene pabC-1 putatively encoding a fold-type IV pyridoxal 5′-phosphate (PLP)-dependent enzyme was found within the antibiotic FR-008/candicidin biosynthetic gene cluster, whose inactivation significantly reduced the productivity of antibiotic FR-008 to about 20 % of the wild-type level. Its specific role in PABA formation was further demonstrated by the successful complementation of an E

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Cui, Ningning, Haihui Tong, Yan Li, et al. "Role of Prealbumin in Predicting the Prognosis of Severely and Critically Ill COVID-19 Patients." American Journal of Tropical Medicine and Hygiene 105, no. 3 (2021): 718–26. http://dx.doi.org/10.4269/ajtmh.21-0234.

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ABSTRACT. Most critically ill patients experience malnutrition, resulting in a poor prognosis. This study aimed to evaluate the association of prealbumin (PAB) with the prognosis for severely and critically ill coronavirus disease 2019 (COVID-19) patients and explore factors related to this association. Patients with laboratory-confirmed COVID-19 from West Campus of Union Hospital in Wuhan from January 29, 2020 to March 31, 2020 were enrolled in this study. Patients were classified into the PAB1 (150–400 mg/L; N = 183) and PAB2 (< 150 mg/L; N = 225) groups. Data collection was performed usi

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Zhang, Chongxu, Xin Wang, Shiwha Park, et al. "Only a subset of the PAB1-mRNP proteome is present in mRNA translation complexes." Protein Science 23, no. 8 (2014): 1036–49. http://dx.doi.org/10.1002/pro.2490.

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Boeck, Ronald, Bruno Lapeyre, Christine E. Brown, and Alan B. Sachs. "Capped mRNA Degradation Intermediates Accumulate in the Yeast spb8-2 Mutant." Molecular and Cellular Biology 18, no. 9 (1998): 5062–72. http://dx.doi.org/10.1128/mcb.18.9.5062.

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ABSTRACT mRNA in the yeast Saccharomyces cerevisiae is primarily degraded through a pathway that is stimulated by removal of the mRNA cap structure. Here we report that a mutation in the SPB8(YJL124c) gene, initially identified as a suppressor mutation of a poly(A)-binding protein (PAB1) gene deletion, stabilizes the mRNA cap structure. Specifically, we find that thespb8-2 mutation results in the accumulation of capped, poly(A)-deficient mRNAs. The presence of this mutation also allows for the detection of mRNA species trimmed from the 3′ end. These data show that this Sm-like protein family m

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Lahoz, Aurelia, María Alcaide-Gavilán, Rafael R. Daga, and Juan Jimenez. "Antagonistic Roles of PP2A-Pab1 and Etd1 in the Control of Cytokinesis in Fission Yeast." Genetics 186, no. 4 (2010): 1261–70. http://dx.doi.org/10.1534/genetics.110.121368.

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Brandariz-Núñez, Alberto, Fuxing Zeng, Quan Ngoc Lam, and Hong Jin. "Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- and RGG-dependent manner." RNA 24, no. 1 (2017): 43–55. http://dx.doi.org/10.1261/rna.062547.117.

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Meaux, Stacie, Ambro van Hoof, and Kristian E. Baker. "Nonsense-Mediated mRNA Decay in Yeast Does Not Require PAB1 or a Poly(A) Tail." Molecular Cell 29, no. 1 (2008): 134–40. http://dx.doi.org/10.1016/j.molcel.2007.10.031.

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Wang, Le, Pan Li, Pei Zeng, et al. "Dosage suppressors of gpn2ts mutants and functional insights into the role of Gpn2 in budding yeast." PLOS ONE 19, no. 12 (2024): e0313597. https://doi.org/10.1371/journal.pone.0313597.

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Gpn2 is a highly conserved protein essential for the assembly of RNA polymerase II (RNAPII) in eukaryotic cells. Mutations in Gpn2, specifically Phe105Tyr and Leu164Pro, confer temperature sensitivity and significantly impair RNAPII assembly. Despite its crucial role, the complete range of Gpn2 functions remains to be elucidated. To further explore these functions, we conducted large-scale multicopy suppressor screening in budding yeast, aiming to identify genes whose overexpression could mitigate the growth defects of a temperature-sensitive gpn2 mutant (gpn2ts) at restrictive temperatures. W

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Wyers, Françoise, Michèle Minet, Marie Elisabeth Dufour, Le Thuy Anh Vo, and François Lacroute. "Deletion of the PAT1 Gene Affects Translation Initiation and Suppresses a PAB1 Gene Deletion in Yeast." Molecular and Cellular Biology 20, no. 10 (2000): 3538–49. http://dx.doi.org/10.1128/.20.10.3538-3549.2000.

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Moqtaderi, Zarmik, Joseph V. Geisberg, and Kevin Struhl. "Extensive Structural Differences of Closely Related 3′ mRNA Isoforms: Links to Pab1 Binding and mRNA Stability." Molecular Cell 72, no. 5 (2018): 849–61. http://dx.doi.org/10.1016/j.molcel.2018.08.044.

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Brambilla, Marco, Francesca Martani, Stefano Bertacchi, Ilaria Vitangeli, and Paola Branduardi. "The Saccharomyces cerevisiae poly (A) binding protein (Pab1): Master regulator of mRNA metabolism and cell physiology." Yeast 36, no. 1 (2018): 23–34. http://dx.doi.org/10.1002/yea.3347.

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Konitufe Claudius, Abubakar Sabo Baba, and Aliyu Abubakar. "Influence of Pulverized Animal Bone and Animal Bone Ash on the Mechanical Properties of Normal Strength Concrete using Response Surface Method." CONSTRUCTION 3, no. 1 (2023): 63–74. http://dx.doi.org/10.15282/construction.v3i1.9097.

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Global warming, improper solid waste and environment degradations are the major challenges facing humankind. One way to lower the effect global warming is to use less energy intensive materials optimally in construction and proper solid waste disposals to protect the environment from it harmful effects. In this study, the mechanical properties of Pulverized Animal Bone (PAB) and Pulverized Animal Bone Ash (PABA) as cement replacement in concrete were examined and the mechanical properties of concrete containing PAB/PABA optimised using response surfaces methodology (RSM). Central composite Des

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Chen, Ruofan, Julia Shangguan, Darren N. Kahan, Joshua A. Riback, D. A. Drummond, and Tobin R. Sosnick. "Molecular basis of stress-triggered phase separation of Pab1 mediated by folded domains rather than disordered regions." Biophysical Journal 121, no. 3 (2022): 146a. http://dx.doi.org/10.1016/j.bpj.2021.11.1988.

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Swisher, Kylie D., and Roy Parker. "Localization to, and Effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on Stress Granules in Saccharomyces cerevisiae." PLoS ONE 5, no. 4 (2010): e10006. http://dx.doi.org/10.1371/journal.pone.0010006.

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BRUNE, C. "Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export." RNA 11, no. 4 (2005): 517–31. http://dx.doi.org/10.1261/rna.7291205.

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Horton, Lynn E., Philip James, Elizabeth A. Craig, and Jack O. Hensold. "The Yeast hsp70 Homologue Ssa Is Required for Translation and Interacts with Sis1 and Pab1 on Translating Ribosomes." Journal of Biological Chemistry 276, no. 17 (2001): 14426–33. http://dx.doi.org/10.1074/jbc.m100266200.

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Valentini, Sandro R., Jason M. Casolari, Carla C. Oliveira, Pamela A. Silver, and Anne E. McBride. "Genetic Interactions of Yeast Eukaryotic Translation Initiation Factor 5A (eIF5A) Reveal Connections to Poly(A)-Binding Protein and Protein Kinase C Signaling." Genetics 160, no. 2 (2002): 393–405. http://dx.doi.org/10.1093/genetics/160.2.393.

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Abstract The highly conserved eukaryotic translation initiation factor eIF5A has been proposed to have various roles in the cell, from translation to mRNA decay to nuclear protein export. To further our understanding of this essential protein, three temperature-sensitive alleles of the yeast TIF51A gene have been characterized. Two mutant eIF5A proteins contain mutations in a proline residue at the junction between the two eIF5A domains and the third, strongest allele encodes a protein with a single mutation in each domain, both of which are required for the growth defect. The stronger tif51A

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Gaillard, Hélène, and Andrés Aguilera. "A Novel Class of mRNA-containing Cytoplasmic Granules Are Produced in Response to UV-Irradiation." Molecular Biology of the Cell 19, no. 11 (2008): 4980–92. http://dx.doi.org/10.1091/mbc.e08-02-0193.

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Nucleic acids are substrates for different types of damage, but little is known about the fate of damaged RNAs. We addressed the existence of an RNA-damage response in yeast. The decay kinetics of GAL1p-driven mRNAs revealed a dose-dependent mRNA stabilization upon UV-irradiation that was not observed after heat or saline shocks, or during nitrogen starvation. UV-induced mRNA stabilization did not depend on DNA repair, damage checkpoint or mRNA degradation machineries. Notably, fluorescent in situ hybridization revealed that after UV-irradiation, polyadenylated mRNA accumulated in cytoplasmic

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Tadauchi, Tomofumi, Toshifumi Inada, Kunihiro Matsumoto, and Kenji Irie. "Posttranscriptional Regulation of HO Expression by the Mkt1-Pbp1 Complex." Molecular and Cellular Biology 24, no. 9 (2004): 3670–81. http://dx.doi.org/10.1128/mcb.24.9.3670-3681.2004.

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ABSTRACT Cells of budding yeast give rise to mother and daughter cells, which differ in that only mother cells express the HO endonuclease gene and are thereby able to switch mating types. In this study, we identified the MKT1 gene as a positive regulator of HO expression. The MKT1 gene encodes a protein with two domains, XPG-N and XPG-I, which are conserved among a family of nucleases, including human XPG endonuclease. Loss of MKT1 had little effect on HO mRNA levels but resulted in decreased protein levels. This decrease was dependent on the 3′ untranslated region of the HO transcript. We sc

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Assis, Ludmila A., Moezio V. C. Santos Filho, Joao R. da Cruz Silva, et al. "Identification of novel proteins and mRNAs differentially bound to the Leishmania Poly(A) Binding Proteins reveals a direct association between PABP1, the RNA-binding protein RBP23 and mRNAs encoding ribosomal proteins." PLOS Neglected Tropical Diseases 15, no. 10 (2021): e0009899. http://dx.doi.org/10.1371/journal.pntd.0009899.

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Poly(A) Binding Proteins (PABPs) are major eukaryotic RNA-binding proteins (RBPs) with multiple roles associated with mRNA stability and translation and characterized mainly from multicellular organisms and yeasts. A variable number of PABP homologues are seen in different organisms however the biological reasons for multiple PABPs are generally not well understood. In the unicellular Leishmania, dependent on post-transcriptional mechanisms for the control of its gene expression, three distinct PABPs are found, with yet undefined functional distinctions. Here, using RNA-immunoprecipitation seq

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Peltz, S. W., J. L. Donahue, and A. Jacobson. "A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae." Molecular and Cellular Biology 12, no. 12 (1992): 5778–84. http://dx.doi.org/10.1128/mcb.12.12.5778-5784.1992.

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To identify trans-acting factors involved in mRNA decay in the yeast Saccharomyces cerevisiae, we have begun to characterize conditional lethal mutants that affect mRNA steady-state levels. A screen of a collection of temperature-sensitive mutants identified ts352, a mutant that accumulated moderately stable and unstable mRNAs after a shift from 23 to 37 degrees C (M. Aebi, G. Kirchner, J.-Y. Chen, U. Vijayraghavan, A. Jacobson, N.C. Martin, and J. Abelson, J. Biol. Chem. 265:16216-16220, 1990). ts352 has a defect in the CCA1 gene, which codes for tRNA nucleotidyltransferase, the enzyme that a

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Peltz, S. W., J. L. Donahue, and A. Jacobson. "A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae." Molecular and Cellular Biology 12, no. 12 (1992): 5778–84. http://dx.doi.org/10.1128/mcb.12.12.5778.

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To identify trans-acting factors involved in mRNA decay in the yeast Saccharomyces cerevisiae, we have begun to characterize conditional lethal mutants that affect mRNA steady-state levels. A screen of a collection of temperature-sensitive mutants identified ts352, a mutant that accumulated moderately stable and unstable mRNAs after a shift from 23 to 37 degrees C (M. Aebi, G. Kirchner, J.-Y. Chen, U. Vijayraghavan, A. Jacobson, N.C. Martin, and J. Abelson, J. Biol. Chem. 265:16216-16220, 1990). ts352 has a defect in the CCA1 gene, which codes for tRNA nucleotidyltransferase, the enzyme that a

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Marin, Ambroise, Emmanuel Denimal, Lucie Bertheau, Stéphane Guyot, Ludovic Journaux, and Paul Molin. "Automatic Counting of Intra-Cellular Ribonucleo-Protein Aggregates in Saccharomyces cerevisiae Using a Textural Approach." Microscopy and Microanalysis 25, no. 1 (2019): 164–79. http://dx.doi.org/10.1017/s1431927619000084.

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AbstractIn the context of microbiology, recent studies show the importance of ribonucleo-protein aggregates (RNPs) for the understanding of mechanisms involved in cell responses to specific environmental conditions. The assembly and disassembly of aggregates is a dynamic process, the characterization of the stage of their evolution can be performed by the evaluation of their number. The aim of this study is to propose a method to automatically determine the count of RNPs. We show that the determination of a precise count is an issue by itself and hence, we propose three textural approaches: a

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Kops, Anne de Bruyn, Jordan E. Burke, and Christine Guthrie. "Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope." Molecular Biology of the Cell 29, no. 21 (2018): 2578–90. http://dx.doi.org/10.1091/mbc.e18-04-0258.

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Correlation between transcriptional regulation and positioning of genes at the nuclear envelope is well established in eukaryotes, but the mechanisms involved are not well understood. We show that brr6-1, a mutant of the essential yeast envelope transmembrane protein Brr6p, impairs normal positioning and expression of the PAB1 and FUR4- GAL1,10,7 loci. Similarly, expression of a dominant negative nucleoplasmic Brr6 fragment in wild-type cells reproduced many of the brr6-1 effects. Histone chromatin immunoprecipitation (ChIP) experiments showed decreased acetylation at the key histone H4K16 res

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Turtola, Matti, M. Cemre Manav, Ananthanarayanan Kumar, et al. "Three-layered control of mRNA poly(A) tail synthesis in Saccharomyces cerevisiae." Genes & Development 35, no. 17-18 (2021): 1290–303. http://dx.doi.org/10.1101/gad.348634.121.

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Biogenesis of most eukaryotic mRNAs involves the addition of an untemplated polyadenosine (pA) tail by the cleavage and polyadenylation machinery. The pA tail, and its exact length, impacts mRNA stability, nuclear export, and translation. To define how polyadenylation is controlled in S. cerevisiae, we have used an in vivo assay capable of assessing nuclear pA tail synthesis, analyzed tail length distributions by direct RNA sequencing, and reconstituted polyadenylation reactions with purified components. This revealed three control mechanisms for pA tail length. First, we found that the pA bin

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Kitamura, Satoshi, Yutaka Oono, and Issay Narumi. "Arabidopsis pab1, a mutant with reduced anthocyanins in immature seeds from banyuls, harbors a mutation in the MATE transporter FFT." Plant Molecular Biology 90, no. 1-2 (2015): 7–18. http://dx.doi.org/10.1007/s11103-015-0389-8.

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Lee, Darren, Takbum Ohn, Yueh-Chin Chiang, et al. "PUF3 Acceleration of Deadenylation in Vivo Can Operate Independently of CCR4 Activity, Possibly Involving Effects on the PAB1–mRNP Structure." Journal of Molecular Biology 399, no. 4 (2010): 562–75. http://dx.doi.org/10.1016/j.jmb.2010.04.034.

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