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Dissertations / Theses on the topic 'PABP'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 May 2024

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1

Grenier, St-Sauveur Valérie. "Caractérisation et fonction de la protéine Nab2 chez Schizosaccharomyces pombe." Mémoire, Université de Sherbrooke, 2014. http://savoirs.usherbrooke.ca/handle/11143/105.

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L’étude qui vous est présentée dans ce mémoire est réalisée chez l’organisme Schizosaccharomyces pombe et elle porte sur la caractérisation de la protéine Nab2, une protéine liant les queues poly(A) ainsi que sur son implication dans la régulation génique. Tout d’abord, il faut savoir qu’il existe quatre modes de régulation (transcriptionnel, post-transcriptionnel, traductionnel et post-traductionnel) dans lesquels interviennent différents types de protéines, en particulier des protéines liant les queues poly(A) des ARN, aussi connues sous le nom de PABPs. Ces protéines reconnaissent l’ARN à
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2

de, Carli da Costa Lima Tamara. "Caracterização funcional de homólogos à proteína de ligação a Cauda Poli-A (PABP) de Leishmania major." Universidade Federal de Pernambuco, 2007. https://repositorio.ufpe.br/handle/123456789/6362.

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Made available in DSpace on 2014-06-12T18:04:28Z (GMT). No. of bitstreams: 2 arquivo6197_1.pdf: 1859004 bytes, checksum: e86e2d8c963670c51f4e1b8266e440a2 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2007<br>A proteína de ligação à cauda poli-A (PABP) se liga a seqüência de poli adenosinas presente na extremidade 3 do mRNA e possui uma multiplicidade de funções dentro da célula. Dentre as funções atribuídas a PABP destaca-se sua participação em eventos da síntese de proteínas, tais como iniciação e terminação da tradução e reciclage
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3

Grenier, St-Sauveur Val??rie. "Caract??risation et fonction de la prot??ine Nab2 chez Schizosaccharomyces pombe." Mémoire, Universit?? de Sherbrooke, 2014. http://savoirs.usherbrooke.ca/handle/11143/105.

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L?????tude qui vous est pr??sent??e dans ce m??moire est r??alis??e chez l???organisme Schizosaccharomyces pombe et elle porte sur la caract??risation de la prot??ine Nab2, une prot??ine liant les queues poly(A) ainsi que sur son implication dans la r??gulation g??nique. Tout d???abord, il faut savoir qu???il existe quatre modes de r??gulation (transcriptionnel, post-transcriptionnel, traductionnel et post-traductionnel) dans lesquels interviennent diff??rents types de prot??ines, en particulier des prot??ines liant les queues poly(A) des ARN, aussi connues sous le nom de PABPs. Ces prot??ine
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4

Roy, Guylaine. "Characterization of PABP-interacting proteins 1 and 2." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84317.

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The 3' poly(A) tail of eukaryotic mRNAs and the poly(A) binding protein (PABP) play key roles in the regulation of translation. Recently, our group identified two human PABP-interacting proteins (Paip), Paip1 and Paip2, which stimulate and repress translation, respectively. Paip2 also inhibits the binding of PABP to the poly(A) tail and competes with Paip1 for binding to PABP. My research project was divided into two parts to allow me to gain a greater understanding of the roles of these two PABP-interacting proteins. First, in order to study the mechanism of interaction of Paip1 and PA
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5

Fantus, Daniel. "The polyadenlyate binding protein (PABP) and translational control /." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80261.

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Translation is the process by which proteins are synthesized from messenger RNAs. This complex process is regulated by a multitude of factors (1). One such factor is the Polyadenylate Binding Protein (PABP), an abundant protein associated with messenger ribonucleoprotein particles (mRNPs) (18). As a result of its interaction with both poly(A) RNA and eukaryotic initiation factor 4G (eIF4G), a component of the tripartite eIF4F cap-binding complex, PABP elicits mRNA circularization and stimulates translation (2). Although the mechanism by which mRNA circularization facilitates translation
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6

Harb, Maya. "Effet de l'interaction de la protéine NSP3 du Rotavirus avec les protéines cellulaires, eIF4G et RoXaN, sur la localisation subcellulaire de PABP." Paris 11, 2008. http://www.theses.fr/2008PA114848.

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La protéine non structurale du Rotavirus, NSP3, interagit avec l’extrémité 3’ des ARNm viraux, avec le facteur d’initiation de la traduction eIF4G, ainsi qu’avec la protéine cellulaire RoXaN. NSP3, en se fixant à l’eIF4G décroche la poly(A) binding protein cytoplasmique (PABPC1) du complexe d’initiation de la traduction, et empêche ainsi l’initiation de la traduction des ARNm cellulaires. De cette façon, la traduction des ARNm viraux est favorisée. Ce travail avait pour objet l’étude du rôle de l’interaction de NSP3 avec RoXaN dont la fonction était jusqu’alors inconnue. Dans une première part
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7

Alsayegh, Maha. "DEF6 is associated with the translational initiation regulating protein synthesis of eIF4E, 4E-T and PABP and colocalises with eIF4E and PABP in the immunological synapse." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/51984/.

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DEF6 is an atypical guanine nucleotide exchange factor (GEF) for Rho GTPases Rac1 and Cdc42, which is highly expressed in mature T cells. DEF6 is recruited to the immunological synapse (IS) following phosphorylation by LCK in response to T cell receptor (TCR) stimulation during inflammation. In resting Jurkat T cells, DEF6 has been known to associate with polysomes and under cellular stress conditions to form cytoplasmic granules colocalising with mRNA decapping enzyme subunit 1 (DCP1), a marker of P-bodies. Hence DEF6 has been linked to mRNA regulation, which includes mRNA translation initiat
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8

Cotnoir-White, David. "NMR study of the interaction between PABP and the translation down-regulator Paip2." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101712.

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The poly(A) binding protein (PABP) is an essential translation factor that enhances protein synthesis and protects mRNAs from degradation. PABP is composed of four RNA recognition motifs (RRM) at its N-terminal and a peptide-interacting C-terminal domain. PABP-interacting proteins 1 (Paip1) and 2 (Paip2) were found to respectively stimulate or inhibit translation. Both Paip 1 and 2 contain two PABP interacting regions (PAM1 and PAM2). In this study, NMR was used to elucidate the mechanism by which Paip2 down-regulates translation through disruption of PABP's binding to poly(A) RNA. A fragment
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9

Lockwood, Donovan Blair. "TDP-43 Modulation of PABP Positive, RNA Stress Granule Formation during Oxidative Stress." Thesis, The University of Arizona, 2015. http://hdl.handle.net/10150/579304.

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RNA dysregulation is a recently recognized disease mechanism in amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disease characterized by muscle atrophy and death of both upper and lower motor neurons. A key feature of the disease is the mislocalization of the RNA binding protein TDP-43 and formation of TDP-43 containing cytoplasmic aggregates in motor neurons and surrounding glia. TDP-43 is known to associate with stress granules, and recent studies in mammalian cell culture have indicated that pathological TDP-43 aggregates may arise from RNA stress granules following prolonge
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10

Wu, Jun. "The study of translational regulation of poly(A)-binding protein, PABP, expression in HeLa cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ31911.pdf.

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11

Sousa, Martins Joao Pedro. "Functional analysis of DAZL-mediated translation activation during mammalian gametogenesis." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9893.

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Gametogenesis is a highly complex process that requires stringent control of gene expression, in which translational regulation plays an essential role. Deleted in Azoospermia-like (DAZL) belongs to the DAZ family of RNA-binding proteins, which are restricted to germ cells, and regulate mRNA translation. Importantly, loss of function of these proteins results in infertility in both males and females in a wide variety of organisms. A model for the mechanism by which DAZL stimulates translation has been proposed based on work in Xenopus laevis (X. laevis) oocytes. In this model, DAZL functions b
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12

Peng, Jing. "Impact of the poly(A) limiting element on mRNA 3' processing efficiency and translation." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1101745063.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xix, 201 p.; also includes graphics. Includes bibliographical references (p. 187-201).
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13

Limousin, Taran. "Effet des microARNs sur la traduction cellulaire et virale." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10312.

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Les microARN jouent un grand rôle dans la régulation de l'expression des gènes bien que leur mécanisme d'action soit encore sujet à débat. Des premières études chez le vers C. elegans aux différents systèmes in vitro qui ont ensuite été développés, plusieurs modèles ont été proposés, comme l'inhibition de la traduction au niveau de l'initiation ou de l'élongation, et la déstabilisation du transcrit par déadénylation. Cependant, à la lumière des découvertes récentes, un consensus semble apparaître et indique que les miARN inhiberaient d'abord la traduction avant d'induire la déadénylation du tr
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14

Miroci, Hatmone [Verfasser], and Evita [Akademischer Betreuer] Mohr. "Identifizierung und Charakterisierung eines neuen PABP-interagierenden Proteins, Makorin RING-Zinkfinger Protein 1 (MKRN1) in Neuronen / Hatmone Miroci ; Betreuer: Evita Mohr." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2018. http://d-nb.info/1167402480/34.

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15

Dizin, Éva. "Rôles cytoplasmiques de la protéine BRCA1 : caractérisation et étude des conséquences fonctionnelles de son interaction avec les protéines PABP et DAP5." Lyon 1, 2006. http://www.theses.fr/2006LYO10136.

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Le gène de prédisposition au cancer du sein BRCA1 code protéine de fonction mal connue. Afin d'initier une étude fonctionnelle de cette proétine, notre équipe a recherché des protéines de liaison à son domaine C-terminal, appelé BRCT. Trois nouveaux partenaires de BRCA1 ont ainsi été identifiés : PABP, DAP5 et ACCA. L'analyse des conséquences fonctionnelles du complexe BRCA1/PABP m'a permis de montrer que BRCA1, via son interaction avec PABP, stimule la traduction protéique. L'étude de l'interaction entre BRCA1 et DAP5 m'a conduite à indentifer un nouveau fragment C-terminal de BRCA1, produit
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16

Lefrère, Valérie. "La protéine se liant au poly(A) des ARNm (PABP) de Drosophile : structure du gène et expression au cours du développement." Toulouse 3, 1991. http://www.theses.fr/1991TOU30263.

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Le role de l'extremite 3 polyadenylee des arnm dans la regulation de leur metabolisme semble lie a son association a une proteine specifique, appelee la poly(a)-binding proteine (pabp). La forte conservation de cette proteine au cours de l'evolution laisse penser qu'elle joue un role important dans cette regulation. Il semble qu'elle soit impliquee dans le controle de la stabilite et de l'efficacite de l'initiation de la traduction de certains arnm. Par criblage d'une banque d'adnc embryonnaires de drosophile avec une sonde adnc humaine, nous avons isole deux classes d'adnc pabp, differant par
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17

LIMA, Tamara De’ Carli da Costa. "Abordagens moleculares voltadas a caracterização funcional dos homólogos da proteína de ligação a cauda poli-A (PABP) em espécies de Leishmania sp." Universidade Federal de Pernambuco, 2012. https://repositorio.ufpe.br/handle/123456789/18536.

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Submitted by Caroline Falcao (caroline.rfalcao@ufpe.br) on 2017-04-10T17:54:57Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) 2012-Tese-TamaraLima.pdf: 15100477 bytes, checksum: 79a87ae32652a2bd9c0dae960dc0a539 (MD5)<br>Made available in DSpace on 2017-04-10T17:54:57Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) 2012-Tese-TamaraLima.pdf: 15100477 bytes, checksum: 79a87ae32652a2bd9c0dae960dc0a539 (MD5) Previous issue date: 2012-09-21<br>Em eucariotos,a proteína de ligação à ca
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18

Xavier, Camila Cavalcanti. "Caracterização de interações entre subunidades do complexo de iniciação da tradução EIF4F e homólogos da proteína de ligação ao poli-A (PABP) de Leishmania sp." Centro de Pesquisas Aggeu Magalhães, 2015. https://www.arca.fiocruz.br/handle/icict/14336.

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Made available in DSpace on 2016-05-19T13:08:18Z (GMT). No. of bitstreams: 2 199.pdf: 2457764 bytes, checksum: f3219878be3144c523ae28e85c474b10 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2015<br>Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil<br>Os tripanossomatídeos são caracterizados por processos moleculares diferenciados como a transcrição policistrônica e regulação pós-transcricional da expressão gênica. Em mamíferos, a tradução se inicia com a ligação do complexo eIF4F (formado pelos eIF4A, eIF4E e
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19

Cosson, Bertrand. "Le Facteur de terminaison de la traduction eRF3 et les protéines de liaison aux ARNm polyadénylés : liens structuraux et fonctionnels." Rennes 1, 2001. http://www.theses.fr/2001REN10120.

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Du gène à la protéine, l'étude des régulations de l'expression des gènes n'a fait que mieux révéler la complexité du monde eucaryote. Les mécanismes post transcriptionnels ont un rôle fondamental indiscutable. Une queue poly(A) est mise en place à l'extrémité de presque tous les ARNm après transcription. Elle joue un rôle important dans le contrôle de la stabilité et de la traduction des ARNm. C'est par la famille des protéines de liaison à la queue poly(A) (PABP) que la queue poly(A) intervient dans l'expression génique. Nous avons montré chez la levure que la PABP n'intervient pas seulement
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20

Chapman, Tajekesa Kudzaishe Pamacheche. "Regulation of PABP1 function by differential post-translational modification." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25875.

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Post-transcriptional control of gene expression is critical for normal cellular function and viability. Poly(A)-binding protein (PABP) 1 is the prototypical member of a family of RNA-binding proteins which are key post-transcriptional regulators. PABP1 is multifunctional, acting as a primary determinant of translation efficiency and mRNA stability, regulating the fate of specific mRNAs, and participating in microRNAmediated regulation and nonsense-mediated mRNA decay. As well as binding various mRNAs, PABP1 achieves its multifunctionality through protein-protein interactions with numerous PABP
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21

Mengardi, Chloé. "Étude de l'effet des microARN sur l'initiation de la traduction dirigée par l'IRES du Virus de l'Hépatite C." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSEN001.

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Les microARN (miARN) sont de petits ARN non-codants qui contrôlent l’expression génique, en s’hybridant, le plus souvent, de manière imparfaite à des séquences spécifiques qui se trouvent généralement dans la région non traduite en 3' (3’UTR) de transcrits cibles. Les miARN guident sur l’ARN messager (ARNm) un complexe protéique appelé RNA-induced Silencing Complex (RISC), composé des protéines Argonaute et TNRC6, qui perturbe l’initiation de la traduction et provoque la déadénylation et la dégradation du transcrit. C'est l’interaction entre le RISC et le complexe de pré-initiation de la tradu
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22

Jerbi, Chaabnia Soumaya. "Rôle du facteur de terminaison de la traduction eRF3 (eukaryotic Release Factor 3) dans la stabilité des ARN messagers." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066391/document.

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La désadénylation des ARNm fait intervenir les complexes de désadénylation PAN2-PAN3 et CCR4-NOT-TOB mais aussi le complexe de terminaison de la traduction eRF1-eRF3. Ces trois complexes ont la capacité d'interagir avec la protéine PABP. Cependant, le rôle d'eRF3 n'est pas clairement établi. Il a été décrit que les facteurs eRF3, PAN3 et TOB sont en compétition pour l'interaction avec PABP et qu'il y a un couplage entre la terminaison de la traduction et la désadénylation assuré par eRF3. Chez l'homme, le gène eRF3/GSPT1 présente 5 formes alléliques qui diffèrent par le nombre de répétitions d
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23

Abaza, Irina. "Drosophila UNR: a factor involved in the translational regulation of dosage compensation." Doctoral thesis, Universitat Pompeu Fabra, 2006. http://hdl.handle.net/10803/78125.

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Dosage compensation is a mechanism that equalizes the expression of X-linked genes in those organisms in which males and females differ in the number of X chromosomes. In Drosophila melanogaster, dosage compensation is achieved by up-regulating the transcription of the single male X chromosome. This effect is mediated by a chromatin remodeling complex known as the Male Specific Lethal (MSL) complex or Dosage Compensation Complex (DCC). In female flies, dosage compensation is inhibited primarily because of the translational repression of the mRNA encoding one of the DCC subunits, MSL-2, by the
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24

Anderson, Ross Calley. "Expression and characterisation of a novel poly(A)-binding protein, PABP5." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/5942.

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The poly(A)-binding proteins (PABPs) are a family of eukaryotic RNA-binding proteins with key roles in mRNA translation and stability. The molecular function of PABPs have been largely revealed through study of the prototypical cytoplasmic poly(A)-binding protein, PABP1. Thus, little is known regarding other PABP family members. PABP5 contains four RNA-recognition motifs characteristic of the cytoplasmic PABPs yet is structurally distinct as it lacks a portion of the C-terminus. This region contains a proline-rich section linked to a globular domain that facilitates a number of protein-protein
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25

Jerbi, Chaabnia Soumaya. "Rôle du facteur de terminaison de la traduction eRF3 (eukaryotic Release Factor 3) dans la stabilité des ARN messagers." Electronic Thesis or Diss., Paris 6, 2015. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2015PA066391.pdf.

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La désadénylation des ARNm fait intervenir les complexes de désadénylation PAN2-PAN3 et CCR4-NOT-TOB mais aussi le complexe de terminaison de la traduction eRF1-eRF3. Ces trois complexes ont la capacité d'interagir avec la protéine PABP. Cependant, le rôle d'eRF3 n'est pas clairement établi. Il a été décrit que les facteurs eRF3, PAN3 et TOB sont en compétition pour l'interaction avec PABP et qu'il y a un couplage entre la terminaison de la traduction et la désadénylation assuré par eRF3. Chez l'homme, le gène eRF3/GSPT1 présente 5 formes alléliques qui diffèrent par le nombre de répétitions d
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26

Thomson, Laura Margaret. "Adrenomedullin, PAMP and adrenocortical function." Thesis, Queen Mary, University of London, 2001. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25124.

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Adrenomedullin (AM) and pro-adrenomedullin N-terminal 20-peptide (PAMP) are peptides recently identified from a rat pheochromocytoma. Both of these peptides are cleavage products of pre-pro-AM. Specific receptors for AM have been characterised in several species, including rat and human. The aim of this study was to investigate the role of PAMP and AM in the adrenal cortex. Using an intact rat capsule preparation PAMP was shown to cause a dosedependent increase in aldosterone secretion, which was accompanied by a dosedependent increase in cAMP release. The effects of PAMP were inhibited by HA1
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27

Navarro, Serer Judith 1990. "Understanding functional interplay between PARP-1 and PARP-2 in T cell development and function." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/481994.

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T-cell homeostasis must be tightly regulated and maintained in order to guarantee appropriate immune responses and prevent immunopathology. This maintenance depends on MHC-TCR interaction and cytokine-mediated signals among others. However, cell intrinsic factors that modulate essential functions in T-cells must be also integrated to support genomic stability and contribute to the control of T-cell homeostasis. The present work establishes a coordinated role of poly (ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function, demonstrated by the defective
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28

Camargo, Ricardo. "Investigação das interações moleculares da proteína citoplasmática ligante à cauda poli(A) : associação PABPC-PABPC." reponame:Repositório Institucional da UnB, 2010. http://repositorio.unb.br/handle/10482/7429.

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Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, 2010.<br>Submitted by Jaqueline Ferreira de Souza (jaquefs.braz@gmail.com) on 2011-04-17T00:58:06Z No. of bitstreams: 1 2010_RicardoCamargo.pdf: 1814504 bytes, checksum: 918ee0ed7e332fdfa90c63a3936aa5f5 (MD5)<br>Approved for entry into archive by Jaqueline Ferreira de Souza(jaquefs.braz@gmail.com) on 2011-04-17T00:58:38Z (GMT) No. of bitstreams: 1 2010_RicardoCamargo.pdf: 1814504 bytes, checksum: 918ee0ed7e332fdfa90c63a3936aa5f5 (MD5)<br>Made available in DSpace on 2011-04-17
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Sartorio, Carolina. "PAP-Style Cases." J PHILOSOPHY INC, 2016. http://hdl.handle.net/10150/625953.

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Over the years, two models of freedom have emerged as competitors: the alternative-possibilities model, which states that acting freely consists (at least partly) in being able to do otherwise, and, more recently, the actual-sequence model, which states that acting freely is exclusively a function of the actual sequence of events issuing in our behavior. In general, a natural strategy when trying to decide between two models of a certain concept is to look for examples that support one model and undermine the other. Frankfurt-style cases have been used for this kind of purpose, to challenge th
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30

Greca, Rossana. "Ruolo della PARP nello stress ossidativo." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1043.

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Abstract Poly(ADP-ribose) polymerases (PARPs) play a crucial role in DNA damage surveillance through their nick sensor functions. Since PARPs over activation leads to an excessive consumption of NAD? and ATP depletion, these enzymes also are involved in the early events of programmed cell death as well as in necrosis. In order to verify the protective action of L-carnosine and trehalose against NO induced cell death, in the present study we examined their effects on the expression of PARP-1, PARP-2 and iNOS in primary rat astrocyte and oligodendrocyte cells, treated with lipopolysaccharide (L
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31

Skoglund, Anders. "Multivariate modelling and monitoring for stabilisation of paperboard manufacturing /." Linköping : Univ, 2004. http://www.bibl.liu.se/liupubl/disp/disp2004/tek903s.pdf.

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32

Boudra, Mohammed-Tayyib. "Facteurs modulant la radiosensibilité : rôle des protéines PARP-1, PARP-2 et Cdk5 et implication de la chromatine." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00662941.

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Les modifications post-traductionnelles des protéines de réparation de l'ADN et des facteurs chromatiniens par poly(ADP-ribose)ylation et par phosphorylation sont essentielles pour le maintien de l'intégrité de l'ADN et de la chromatine, en particulier dans la réponse cellulaire aux dommages de l'ADN induits par radiation ionisantes (RI). Parmi les protéines impliquées dans ces deux processus nous trouvons, respectivement, la poly(ADP-ribose) polymérase-1 (PARP-1) et PARP-2, et la kinase dépendante des cyclines Cdk5 : PARP-1 et PARP-2 sont impliqué dans le mécanisme de réparationdes cassures s
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Düll, Fabian [Verfasser], Christian [Akademischer Betreuer] Papp, Christian [Gutachter] Papp, and Jörg [Gutachter] Libuda. "Metal Nanocluster Arrays as Model System for Catalysts / Fabian Düll ; Gutachter: Christian Papp, Jörg Libuda ; Betreuer: Christian Papp." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2019. http://d-nb.info/1202146015/34.

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Ahmed, Zina. "Poly-ADP ribos polymeras (PARP) inhibitorers effekt på bröstcancer : Poly-ADP ribos polymeras (PARP) inhibitorers effekt på bröstcancer." Thesis, Umeå universitet, Kemiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103397.

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35

Siddiqui, Nadeem. "Structure and function of the PABC domain." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102727.

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The poly (A)-binding protein (PABP) is an essential protein found in all eukaryotes and functions in mRNA metabolic and translational processes. Structurally, PABP consists of two distinct regions. The N-terminal half contains four RNA recognition motifs that bind to the poly (A)-tail of mRNA, while the C-terminal segment contains a unique peptide binding module referred to as the PABC domain. The function of this domain in PABP is to recruit proteins containing a very specific 'PAM-2' motif to the mRNP complex. Unique to metazoans, a PABC domain is also found in the hyperplastic discs tumor s
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36

Gittens, William. "PARP/XRCC1 surveillance of the human genome." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/76255/.

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DNA single strand breaks (SSBs) are one of the most common lesions to genomic DNA, arising from various endogenous and exogenous sources. Single strand break repair (SSBR) constitutes a biochemical pathway whereby SSBs are detected, enzymatically processed and ligated. Whilst the general mechanisms of SSBR are relatively well described in vitro, there are remaining questions concerning how the pathway operates in vivo. For example, an early step in SSBR is thought to be the poly(ADP-ribose) polymerase (PARP)-dependent modification of SSB-proximal proteins with ADP-ribose, which is a signal for
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Muñoz, Frances M. "Calcium Modulation of PARP-mediated Cell Death." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/347337.

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Many pathological conditions, including renal disease, are associated with oxidative stress. 2,3,5-tris(Glutathion-S-yl)hydroquinone (TGHQ), a potent nephrotoxic and nephrocarcinogenic metabolite of benzene and hydroquinone, generates reactive oxygen species (ROS), can cause DNA strand breaks, and the subsequent activation of DNA repair proteins, including poly(ADP-ribose) polymerase (PARP)-1. Under robust oxidative damage, PARP-1 is hyper-activated, which causes elevations in intracellular calcium concentrations (iCa²⁺), NAD⁺ and ATP depletion, and ultimately necrotic cell death. The role of
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38

Michels, Judith. "Les Inhibiteurs de PARP dans le Traitement des Cancers Chimio-Résistants. Etude pré-clinique sur la Dépendance à PARP." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-01063796.

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Introduction Le cancer bronchique est un problème de santé publique en étant la première cause de décès par cancer dans le monde. Il reste de mauvais pronostic avec une résistance au Cisplatine qui est inéluctable dans l'histoire naturelle de la maladie. Nous nous sommes intéressés à l'association du CDDP aux inhibiteurs de la Poly(ADP-ribose) polymérase. Les inhibiteurs pharmacologiques de PARP sont source d'optimisme en oncologie clinique en monothérapie pour des tumeurs déficientes pour une voie de réparation de l'ADN et en association aux cytotoxiques classiques.Matériel et méthodes Nous a
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Michels, Judith. "Les inhibiteurs de PARP dans le traitement des cancers chimio-résistants : étude pré-clinique sur la dépendance à PARP." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T049/document.

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Introduction Le cancer bronchique est un problème de santé publique en étant la première cause de décès par cancer dans le monde. Il reste de mauvais pronostic avec une résistance au Cisplatine qui est inéluctable dans l’histoire naturelle de la maladie. Nous nous sommes intéressés à l’association du CDDP aux inhibiteurs de la Poly(ADP-ribose) polymérase. Les inhibiteurs pharmacologiques de PARP sont source d’optimisme en oncologie clinique en monothérapie pour des tumeurs déficientes pour une voie de réparation de l’ADN et en association aux cytotoxiques classiques.Matériel et méthodes Nous a
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Bachmann, Philipp [Verfasser], Christian [Akademischer Betreuer] Papp, and Christian [Gutachter] Papp. "Fundamental studies on the heterogeneously catalyzed dehydrogenation reactions of hydrogen carrier molecules / Philipp Bachmann ; Gutachter: Christian Papp ; Betreuer: Christian Papp." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2019. http://d-nb.info/1197304576/34.

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Bachmann, Philipp Alois Norbert [Verfasser], Christian [Akademischer Betreuer] Papp, and Christian [Gutachter] Papp. "Fundamental studies on the heterogeneously catalyzed dehydrogenation reactions of hydrogen carrier molecules / Philipp Bachmann ; Gutachter: Christian Papp ; Betreuer: Christian Papp." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2019. http://d-nb.info/1197304576/34.

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42

Pirotte, Evelyne. "PARP inhibition in novel oropharyngeal cancer cell lines." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/109437/.

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In recent decades many developed countries have seen unprecedented increases in incidence of Human Papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC). HPV-positive OPSCC represents a new disease entity and preclinical assessment of novel therapies is hampered by a lack of relevant in vitro models. It is well-established that HPV-positive OPSCC patients generally survive longer than HPV-negative patients, and this may be partly attributable to defective repair of DNA double-strand-breaks in HPV-positive tumours. This study aimed to develop novel cell line models of HP
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43

Lloyd, Simon. "Mapping PAMP responses and disease resistance in brassicas." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/49479/.

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The first layer of active defence in plants is based on the perception of pathogen-associated molecular patterns (PAMPs) leading to PAMP-triggered immunity (PTI). PTI is increasingly being investigated in crop plants, where it may have potential to provide durable disease resistance in the field. Limiting this work, however, is an absence of reliable bioassays to investigate PAMP responses in some species. Presented here is a series of methods to investigate PTI in Brassica napus. The assays allow measuring early cell signalling responses, gene expression changes, cell wall reinforcement, meta
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Niebergall, Roda. "Characterisation of potential regulators of PAMP-triggered immunity." Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/42367/.

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An essential part of plant innate immunity is the perception of pathogen-associated molecular patterns (PAMPs) through surface-localised pattern-recognition receptors (PRRs). EFR and FLS2 are well characterised PRRs, which recognise the bacterial elongation factor Tu and flagellin, respectively. A variety of downstream responses upon PAMP perception have been described. However, it is still poorly understood how EFR- and FLS2-dependent signalling is mediated. Here, I used two different approaches in order to identify novel components of both signalling pathways. First, I characterised seven ca
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Martín, Raquel de Lourdes. "Activina A, Inhibina A, PP13 y PAPP-A." Master's thesis, Universidad Nacional de Cuyo. Facultad de Ciencias Médicas, 2016. http://bdigital.uncu.edu.ar/8271.

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La preeclampsia (PE), es un proceso mórbido específico, multisistémico e idiopático de la gestación y del puerperio humano. Se produce en el 3-14 % de todos los embarazos, en el 30% de las gestaciones múltiples, en el 30% de los embarazos en mujeres diabéticas, y en el 20% de las gestaciones en las mujeres con hipertensión crónica. Sin embargo, dos tercios de todos los casos ocurren en embarazadas que, fuera de este desorden, son nulíparas sin otras complicaciones aparentes. Mundialmente, se atribuyen más de 100.000 muertes maternas al año por la aparición de PE y eclampsia (convulsiones o com
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Almén, Sara, and Karin Hellberg. "Från papp till app: Digitala verktyg i förskolan." Thesis, Malmö universitet, Fakulteten för lärande och samhälle (LS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-39460.

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Geraets, Liesbeth. "Dietary PARP-1 inhibitors as anti-inflammatory compounds." Maastricht : Maastricht : Universitaire Pers ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=14252.

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48

Nitta, Yukino. "Regulation of plant defense responses downstream of PAMP receptors." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/51596.

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49

Silva, Marco Aurélio de Sousa Costa e. "Um processo de apoio à continuidade de projeto - PACP." Universidade de Fortaleza, 2013. http://dspace.unifor.br/handle/tede/91061.

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Made available in DSpace on 2019-03-29T23:38:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-06-14<br>In software development, many are the projects to be completed end up frustrating the initial expectations of its development and, in many cases, due to the unsatisfactory performance presented. Performance testing can assist in making decisions in advance about the continuity of the project, in order not to develop a software useless. This paper aims to make a proposal for a process to support the development of software project, which seeks to use performance testing without the
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50

Almeida, Gilberto Serrano de. "Pre-clinical imaging evaluation of the PARP inhibitor rucaparib." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2033.

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Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA-binding enzyme involved in DNA repair by the base-excision pathway. The inhibition of PARP1 is being investigated as a cancer treatment. Rucaparib (CO338) is a potent PARP 31 inhibitor currently in Phase II clinical development. In this thesis P in vivo MR Spectroscopy (MRS) and Dynamic Contrast Enhanced (DCE) MRI were used to study acute effects of rucaparib on energy metabolism and tumour vasculature. 1 31 18 18 Ex vivo H and P-MRS, and in vivo [ F]FLT and [ F]FDG-PET, were used to study effects of treatment with rucaparib on tumour metabolism a
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