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Journal articles on the topic 'Paced Auditory Serial Addition Test (PASAT)'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Rogers, Jeffray, and Allison Fox. "Event-related potential practice effects on the Paced Auditory Serial Addition Test (PASAT)." Advances in Cognitive Psychology 8, no. 4 (2012): 281–91. http://dx.doi.org/10.5709/acp-0123-z.

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Cardinal, KS, SM Wilson, BS Giesser, AE Drain, and NL Sicotte. "A longitudinal fMRI study of the paced auditory serial addition task." Multiple Sclerosis Journal 14, no. 4 (2008): 465–71. http://dx.doi.org/10.1177/1352458507084263.

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The paced auditory serial addition task (PASAT) is a test of working memory and attention that is frequently abnormal in MS and is used serially to assess cognitive dysfunction as part of the MS Functional Composite in clinical trials. Previous studies using functional MRI (fMRI) during PASAT performance have shown significant differences in activation patterns between healthy controls and MS patients matched for performance, but serial fMRI measures have not been reported. A confound is that learning effects are common with repeated PASAT testing, diminishing over successive trials. After mea

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Nagels, G., M. B. D'hooghe, D. Kos, S. Engelborghs, and P. P. De Deyn. "Within-session practice effect on paced auditory serial addition test in multiple sclerosis." Multiple Sclerosis Journal 14, no. 1 (2008): 106–11. http://dx.doi.org/10.1177/1352458507080062.

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The paced auditory serial addition test (PASAT) is increasingly used in multiple sclerosis (MS) studies. Since these studies rely on repeated assessments with relatively short inter-test intervals, practice effects can be a confounding factor. We examined intra-session PASAT practice effects in 70 relapsing remitting (RR) and 40 secondary progressive (SP) patients. The average number of correct answers increased from 39.6 ± 11.7 in the first PASAT run to 43.8 ± 11.4 in the second run for the RR group, and from 39.1 ± 11.6 to 41.8 ± 13.3 in the SP group. PASAT scores showed a consistent decreas

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4

TOMBAUGH, T. "A comprehensive review of the Paced Auditory Serial Addition Test (PASAT)." Archives of Clinical Neuropsychology 21, no. 1 (2006): 53–76. http://dx.doi.org/10.1016/j.acn.2005.07.006.

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Brooks, Joseph Bruno Bidin, Vinicius Oliveira Giraud, Youssef Jamal Saleh, Samuel Jose Rodrigues, Lucas Afonso Daia, and Yara Dadalti Fragoso. "Paced auditory serial addition test (PASAT): a very difficult test even for individuals with high intellectual capability." Arquivos de Neuro-Psiquiatria 69, no. 3 (2011): 482–84. http://dx.doi.org/10.1590/s0004-282x2011000400014.

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OBJECTIVE: To assess the difficulty of paced auditory serial addition test (PASAT) in a population of high intellectual level, under ideal cognitive testing circumstances. METHOD: One hundred medical students underwent PASAT testing. They had slept well the night before, they had eaten before the assessment, they were not using any drugs that could affect the central nervous system and they did not have depression, anxiety or any chronic disease. RESULTS: The average result from the three-second version of PASAT was 57.5% and, from the two-second version, it was 44.3%. CONCLUSION: Even under i

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Kane, R. L., B. F. Johnson, and K. E. Fletcher. "The Paced Auditory Serial Addition Test (PASAT): Practice effects and drug sensitivity." Archives of Clinical Neuropsychology 5, no. 2 (1990): 182. http://dx.doi.org/10.1093/arclin/5.2.182.

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Pollard, A., A. Hauson, N. Stelmach, et al. "A-25 Paced Auditory Serial Addition Test in Individuals with Cocaine Versus Methamphetamine Dependence." Archives of Clinical Neuropsychology 34, no. 6 (2019): 884. http://dx.doi.org/10.1093/arclin/acz034.25.

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Abstract Objective Research suggests that cocaine and methamphetamine differ in their impact on executive functions (EF). The Paced Auditory Serial Addition Test (PASAT) is used to assess working memory; a component of EF. The purpose of this meta-analysis was to examine the difference between the effect of these two drugs on PASAT scores. Data Selection Three researchers independently searched nine databases (e.g., PsycINFO, Pubmed, ProceedingsFirst), extracted required data, and calculated effect sizes. Inclusion criteria identified studies that had (a) compared cocaine or methamphetamine de

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Williams, J., K. O’Rourke, M. Hutchinson, and N. Tubridy. "The Face-Symbol Test and the Symbol-Digit Test are not reliable surrogates for the Paced Auditory Serial Addition Test in multiple sclerosis." Multiple Sclerosis Journal 12, no. 5 (2006): 599–604. http://dx.doi.org/10.1177/1352458506070752.

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The Paced Auditory Serial Addition Test (PASAT) is the chosen task for cognitive assessment in the multiple sclerosis functional composite (MSFC) and a widely used task in neuropsychological studies of people with multiple sclerosis (MS), but is unpopular with patients. The Face-Symbol Test (FST) and Symbol-Digit Tests (SDT) are alternative methods of cognitive testing in MS, which are easily administered and patient-friendly. In order to evaluate the potential of the FST as a possible surrogate for the PASAT, we directly compared the FST to the PASAT and the SDT in a cohort of 50 MS patients

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Anhoque, Carolina Fiorin, Laurentino Biccas Neto, Simone Cristina Aires Domingues, Antônio Lúcio Teixeira, and Renan Barros Domingues. "Cognitive impairment in patients with clinically isolated syndrome." Dementia & Neuropsychologia 6, no. 4 (2012): 266–69. http://dx.doi.org/10.1590/s1980-57642012dn06040011.

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ABSTRACT Cognitive abnormalities have been extensively studied in Multiple Sclerosis (MS). However, little is known about the cognitive involvement in patients with Clinically Isolated Syndrome (CIS). Objective: This study aimed to investigate cognitive impairment in patients with CIS compared with healthy subjects. Methods: 18 CIS patients and 18 controls were subjected to the Wechsler memory scale, Rey Auditory Verbal Learning, Rey Complex Figure, Paced Auditory Serial Addition, Digit Span, verbal fluency, Stroop color card test, D2, and Digit Symbol tests. Results: CIS patients had signific

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Razjouyan, Javad, Shariar Gharibzadeh, Ali Fallah, and Abtin Khodadi. "A Revisited View of the Paced Auditory Serial Addition Test (PASAT) in Multiple Sclerosis." Journal of Neuropsychiatry and Clinical Neurosciences 22, no. 4 (2010): 451.e38. http://dx.doi.org/10.1176/jnp.2010.22.4.451.e38.

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Ozakbas, S., B. Ormeci, B. B. Kivircik Akdede, K. Alptekin, and E. Idiman. "Utilization of the auditory consonant trigram test to screen for cognitive impairment in patients with multiple sclerosis: comparison with the paced auditory serial addition test." Multiple Sclerosis Journal 10, no. 6 (2004): 686–89. http://dx.doi.org/10.1191/1352458504ms1111oa.

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Several screening methods have been evaluated, but most of them are insensitive to MS-related cognitive impairment. The Auditory Consonant Trigram (ACT) test, which contains core features required for a working memory task, has been used to test neuro-cognitive function in different samples of patients to examine the status of working memory. The aim of the present study was to investigate the correlation between ACT and the Paced Auditory Serial Addition Test (PASAT), and the usefulness of ACT for evaluating the cognitive impairment in MS in a brief visit. A total of 109 consecutive patients

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Barker-Collo, Suzanne L. "Concurrent Validity of the PASAT and Adjusting-PSAT in Patients with Multiple Sclerosis." International Journal of MS Care 6, no. 4 (2004): 130–35. http://dx.doi.org/10.7224/1537-2073-6.4.130.

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Impaired information processing speed (IPS) is common in multiple sclerosis (MS). Performance on the Paced Auditory Serial Addition Test (PSAT)—the measure recommended by the United States National MS Society Task Force to track changes in IPS—does not indicate the precise speed at which IPS breaks down. A newer version of the task, the Adjusted Paced Serial Addition Test (A-PSAT), provides such an index. This study examined the relationship between PASAT and A-PSAT performance in a sample of 52 individuals with MS. Those with relapsing-remitting MS (RRMS) were significantly younger and had si

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PARMENTER, BRETT A., JANET L. SHUCARD, RALPH H. B. BENEDICT, and DAVID W. SHUCARD. "Working memory deficits in multiple sclerosis: Comparison between then-back task and the Paced Auditory Serial Addition Test." Journal of the International Neuropsychological Society 12, no. 5 (2006): 677–87. http://dx.doi.org/10.1017/s1355617706060826.

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Working memory (WM) deficits are common in multiple sclerosis (MS). The Paced Auditory Serial Addition Test (PASAT) is used frequently to measure WM in clinical settings. Then-back paradigm is used often in experimental studies of WM. One unique component of then-back task is that it provides a measure of reaction time (RT), an additional behavioral index of processing speed and task difficulty. Despite the use of both tasks to measure WM, their common variance has not been documented. We tested 32 MS patients and 20 controls; performance measures were obtained for both tasks. Compared with co

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Sousa, Claudia Sofia, Mariana Rigueiro Neves, Ana Margarida Passos, Aristides Ferreira, and Maria José Sá. "Paced Auditory Serial Addition Test (PASAT 3.0 s): Demographically corrected norms for the Portuguese population." Applied Neuropsychology: Adult 25, no. 5 (2017): 417–23. http://dx.doi.org/10.1080/23279095.2017.1323752.

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Coo, H., W. M. Hopman, C. M. Edgar, E. V. McBride, and D. G. Brunet. "The Paced Auditory Serial Addition Test: to what extent is it performed as instructed, and is it associated with disease course?" Multiple Sclerosis Journal 11, no. 1 (2005): 85–89. http://dx.doi.org/10.1191/1352458505ms1124oa.

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One commonly used outcome measure in multiple sclerosis (MS) clinical trials is the Multiple Sclerosis Functional Composite, which includes the Paced Auditory Serial Addition Test (PASAT) as a measure of cognitive function. Concerns have been raised about the standard PASAT scoring method, whereby the number of correct responses is summed. This method does not take into account whether the test is performed as intended, which may affect interpretation of the results. Accordingly, another scoring method has been proposed, which examines the number of times a correct response is immediately prec

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FISK, JOHN D., and CATHERINE J. ARCHIBALD. "Limitations of the Paced Auditory Serial Addition Test as a measure of working memory in patients with multiple sclerosis." Journal of the International Neuropsychological Society 7, no. 3 (2001): 363–72. http://dx.doi.org/10.1017/s1355617701733103.

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The Paced Auditory Serial Addition Test (PASAT) is a commonly used procedure that combines elements of both a working memory task and a test of information processing speed. Patients with multiple sclerosis (MS) have consistently been found to be impaired on this test and it has been recommended as a core outcome measure in clinical trials. The standard score for this task is the number of correct responses at each stimulus presentation rate but a concern has been raised that subjects may ignore some test items in order to chunk the information into manageable portions and avoid performing sev

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Chaudhari, Falguni A., Parag S. Shah, and Ujjwala Deshpandey. "Cognitive functions in first degree normative relative of patients with schozophrenia." International Journal of Research in Medical Sciences 6, no. 10 (2018): 3211. http://dx.doi.org/10.18203/2320-6012.ijrms20183833.

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Background: Schizophrenia is severe disorders and imposes a considerable burden on patients, their families and society. Schizophrenia tends to run in family, like most mental disorder shows complex inheritance. Therefore, it is important to increase our knowledge about the disorder. Cognitive dysfunction is one of the core features of Schizophrenia. This study aims to compare the cognitive function of first degree unaffected relative of patient of schizophrenia and a group of healthy control.Methods: The study include 48 first degree normative relative of patient with Schizophrenia and 48 con

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Sonder, Judith M., Jessica Burggraaff, Dirk L. Knol, Chris H. Polman, and Bernard MJ Uitdehaag. "Comparing long-term results of PASAT and SDMT scores in relation to neuropsychological testing in multiple sclerosis." Multiple Sclerosis Journal 20, no. 4 (2013): 481–88. http://dx.doi.org/10.1177/1352458513501570.

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Background and objectives: The Symbol Digit Modalities Test (SDMT) shows advantages over the Paced Auditory Serial Addition Test (PASAT) as a cognitive test in patients with multiple sclerosis (MS). To determine which of these tests is most valid and reliable over time as an indicator of the cognitive state of MS patients, long-term test results of both tests were compared in relation to scores of the Brief Repeatable Battery of Neuropsychological tests (BRBN). Methods: For 485 MS patients visiting the VU University Medical Center Amsterdam for different research projects, a total number of 10

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Penner, Iris-Katharina, Brigitte Stemper, Pasquale Calabrese, et al. "Effects of interferon beta-1b on cognitive performance in patients with a first event suggestive of multiple sclerosis." Multiple Sclerosis Journal 18, no. 10 (2012): 1466–71. http://dx.doi.org/10.1177/1352458512442438.

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Background: Cognitive dysfunction occurs at the earliest stages of multiple sclerosis (MS), including the stage of clinically isolated syndrome (CIS). Methods: We evaluated the impact of interferon beta-1b (IFNβ-1b) 250 µg on cognitive performance during the CIS stage in the BENEFITstudy. Cognition was assessed by Paced Auditory Serial Addition Test-3” (PASAT-3”) scores. Results: Improvement in PASAT-3” score from baseline to year two was greater for IFNβ-1b treatment than placebo in patients not reaching clinically definite MS (CDMS) by year two. The treatment effect was maintained at year fi

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Bever, CT, L. Grattan, HS Panitch, and KP Johnson. "The brief repeatable battery of neuropsychological tests for multiple sclerosis: a preliminary serial study." Multiple Sclerosis Journal 1, no. 3 (1995): 165–69. http://dx.doi.org/10.1177/135245859500100306.

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The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) for MS consisting of the selective reminding, 10136 spatial recall, symbol digit modalities, paced auditory serial addition (PASAT) and word list generation tests is a sensitive measure of early cognitive impairment in MS patients. We administered it to 19 chronic stable MS patients every 60 days for 120 days to examine variability. The mean coefficient of variation for the tests ranged from 18% to 22%. A significant practice effect was seen in the PASAT results (P<0.05) using the Wilcoxon signed rank test These results sugges

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Dujardin, Kathy, Caroline Denève, Mélanie Ronval, et al. "Is the Paced Auditory Serial Addition Test (Pasat) a Valid Means of Assessing Executive Function in Parkinson's Disease?" Cortex 43, no. 5 (2007): 601–6. http://dx.doi.org/10.1016/s0010-9452(08)70490-8.

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Sherman, Elisabeth M. S., Esther Strauss, and Frank Spellacy. "Validity of the paced auditory serial addition test (pasat) in adults referred for neuropsychological assessment after head injury." Clinical Neuropsychologist 11, no. 1 (1997): 34–45. http://dx.doi.org/10.1080/13854049708407027.

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Barker-Collo, Suzanne L., and Suzanne C. Purdy. "Determining the Presence of Reliable Change over Time in Multiple Sclerosis." International Journal of MS Care 15, no. 4 (2013): 170–78. http://dx.doi.org/10.7224/1537-2073.2013-007.

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People with multiple sclerosis (MS) often undergo repeated assessments. Methods for determining whether an individual's change in test results over time is reliable require further study. A sample of individuals with MS (N = 52) was assessed at baseline and at 6-month follow-up using the Paced Auditory Serial Addition Test (PASAT), Simple Adjusting–Paced Serial Addition Test (A-PSAT), and Victoria Stroop test. Two methods for determining the reliability of an individual's change over time were examined. The Reliable Change Index (RCI) identified few individuals who declined reliably between ba

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Roca, M., T. Torralva, F. Meli, et al. "Cognitive deficits in multiple sclerosis correlate with changes in fronto-subcortical tracts." Multiple Sclerosis Journal 14, no. 3 (2008): 364–69. http://dx.doi.org/10.1177/1352458507084270.

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Cognitive function and diffusion tensor imaging were assessed in a group of 12 patients with early relapsing—remitting multiple sclerosis (disease duration ≤3 years), and mild clinical disability (expanded disability status scale ≤2), as well as in 12 control subjects. Patients showed impairment in immediate logical memory and delayed recall with the Rey auditory verbal learning test. No significant differences in classical executive tests were observed. In contrast, differences were found for specific executive tests including IOWA Gambling Task, multiple errands test hospital version (MET) a

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Sandry, Joshua, Jessica Paxton, and James F. Sumowski. "General Mathematical Ability Predicts PASAT Performance in MS Patients: Implications for Clinical Interpretation and Cognitive Reserve." Journal of the International Neuropsychological Society 22, no. 3 (2016): 375–78. http://dx.doi.org/10.1017/s1355617715001307.

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AbstractObjectives: The Paced Auditory Serial Addition Test (PASAT) is used to assess cognitive status in multiple sclerosis (MS). Although the mathematical demands of the PASAT seem minor (single-digit arithmetic), cognitive psychology research links greater mathematical ability (e.g., algebra, calculus) to more rapid retrieval of single-digit math facts (e.g., 5+6=11). The present study evaluated the hypotheses that (a) mathematical ability is related to PASAT performance and (b) both the relationship between intelligence and PASAT performance as well as the relationship between education an

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Solari, A., A. Motta, D. Radice, and L. Mendozzi. "A shortened version of PASAT-3 is feasible." Multiple Sclerosis Journal 13, no. 8 (2007): 1020–25. http://dx.doi.org/10.1177/1352458507077619.

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The Paced Auditory Serial Addition Test (PASAT), most used neuropsychological test in people with multiple sclerosis (pwMS), is available as PASAT-3 and more difficult PASAT-2. We determined PASAT performance in 105 pwMS and 105 matched controls and assessed the utility of a shortened PASAT-3 version. Qualitative and quantitative analyses were performed, the latter involving assessment of dyads (two consecutive correct responses) and singles (correct response between two omitted responses). Based on provisional results we then calculated the sensitivity of the first 20 items of PASAT-3 in rela

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Rao, S. M., A. L. Martin, R. Huelin, et al. "Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis." Multiple Sclerosis International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/975803.

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Objectives. To examine relationships between conventional MRI measures and the paced auditory serial addition test (PASAT) and symbol digit modalities test (SDMT).Methods.A systematic literature review was conducted. Included studies had ≥30 multiple sclerosis (MS) patients, administered the SDMT or PASAT, and measured T2LV or brain atrophy. Meta-analysis of MRI/information processing speed (IPS) correlations, analysis of MRI/IPS significance tests to account for reporting bias, and binomial testing to detect trends when comparing correlation strengths of SDMT versus PASAT and T2LV versus atro

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Riccitelli, Gianna C., Elisabetta Pagani, Mariaemma Rodegher, et al. "Imaging patterns of gray and white matter abnormalities associated with PASAT and SDMT performance in relapsing-remitting multiple sclerosis." Multiple Sclerosis Journal 25, no. 2 (2017): 204–16. http://dx.doi.org/10.1177/1352458517743091.

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Objectives: To map the regional patterns of white matter (WM) microstructural abnormalities and gray matter (GM) atrophy exclusively associated with reduced performance in the Symbol Digit Modalities Test (SDMT) and Paced Auditory Serial Addition Test (PASAT) in relapsing-remitting (RR) multiple sclerosis (MS) patients. Methods: In all, 177 RRMS patients and 80 healthy controls (HC) were studied. WM microstructural abnormalities were investigated on diffusion tensor images using tract-based spatial statistics analysis, and regional GM atrophy was estimated on three-dimensional (3D) T1-weighted

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Brochet, B., MSA Deloire, M. Bonnet, et al. "Should SDMT substitute for PASAT in MSFC? A 5-year longitudinal study." Multiple Sclerosis Journal 14, no. 9 (2008): 1242–49. http://dx.doi.org/10.1177/1352458508094398.

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Background The multiple sclerosis functional composite (MSFC) includes the Paced Auditory Serial Addition test (PASAT) as a measure of cognition. Objectives and methods We compared the MSFC incorporating the Symbol Digit Modalities test (SDMT) (MSFC [sdmt]) to the usually applied MSFC (MSFC [pasat]) in a sample of 46 ptients with relapsing–remitting MS who were followed over a five-year period. Magnetic resonance imaging was performed at baseline. Results The Expanded Disability Status scale (EDSS) deteriorated significantly over 5 years ( P < 0.01), but MSFC scores remained stable. MSFC [s

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Walker, Lisa A. S., Amy Cheng, Jason Berard, Lindsay I. Berrigan, Laura M. Rees, and Mark S. Freedman. "Tests of Information Processing Speed." International Journal of MS Care 14, no. 2 (2012): 92–99. http://dx.doi.org/10.7224/1537-2073-14.2.92.

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Reduction in information processing speed (IPS) is a key deficit in multiple sclerosis (MS). The Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities Test (SDMT), and Computerized Test of Information Processing (CTIP) are used to measure IPS. Both the PASAT and SDMT are sensitive to deficits in IPS. The CTIP, a newer task, also shows promise. The PASAT has several limitations, and it is often perceived negatively by patients. Yet little supporting quantitative evidence of such perceptions has been presented. Therefore, in this study, subjective ratings of likeability, difficult

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Finlayson, Marcia, Eynat Shevil, Ping Luo, Hua Yun Chen, and Virgil Mathiowetz. "Effects of Cognition on Quiz Performance, Behavior Change, and Vitality After Energy Conservation Course Among People With Multiple Sclerosis." International Journal of MS Care 9, no. 1 (2007): 13–21. http://dx.doi.org/10.7224/1537-2073-9.1.13.

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This secondary analysis of randomized control trial data evaluated the influence of cognitive abilities on the outcomes of people with multiple sclerosis (MS) who participated in a 6-week community-based energy conservation education program. Baseline measures of cognitive status included the four scales from the Neuropsychological Screening Battery for MS: Consistent Long-Term Retrieval Test (CLTR), Word List Generation Test (WLGT), Paced Auditory Serial Addition Test (PASAT), and Spatial Recall Test (SRT). Scores on knowledge quizzes, number of energy conservation strategies used postinterve

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Scherer, P., I. K. Penner, A. Rohr, et al. "The Faces Symbol Test, a newly developed screening instrument to assess cognitive decline related to multiple sclerosis: first results of the Berlin Multi-Centre FST Validation Study." Multiple Sclerosis Journal 13, no. 3 (2007): 402–11. http://dx.doi.org/10.1177/1352458506069674.

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Reliable, language-independent, short screening instruments to test for cognitive function in patients with multiple sclerosis (MS) remain rare, despite the high number of patients affected by cognitive decline. We developed a new, short screening instrument, the Faces Symbol Test (FST), and compared its diagnostic test characteristics with a composite of the Digit Symbol Substitution Test (DSST) and the Paced Auditory Serial Addition Test (PASAT), in 108 MS patients and 33 healthy controls. An Informant-Report Questionnaire, a Self-Report Questionnaire, and a neurologist's estimation of the E

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Omisade, Antonina, John D. Fisk, Raymond M. Klein, Matthias Schmidt, Sultan Darvesh, and Virender Bhan. "Information Processing and Magnetic Resonance Imaging Indices of Brain Pathology in Multiple Sclerosis." International Journal of MS Care 14, no. 2 (2012): 84–91. http://dx.doi.org/10.7224/1537-2073-14.2.84.

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Accumulation of central nervous system (CNS) pathology affects cognitive processing speed and efficiency and is thought to underlie attentional and executive deficits in multiple sclerosis (MS). Most clinical neuropsychological tests are multifactorial and are limited in their sensitivity to specific cognitive processes. This may, in part, account for the low to moderate correlations between clinical test results and magnetic resonance imaging (MRI) indices of brain pathology. We compared the ability of a clinical and an experimental test of cognitive processing speed to differentiate domain-s

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Lechner-Scott, J., T. Kerr, B. Spencer, S. Agland, A. Lydon, and PW Schofield. "The Audio Recorded Cognitive Screen (ARCS) in patients with multiple sclerosis: a practical tool for multiple sclerosis clinics." Multiple Sclerosis Journal 16, no. 9 (2010): 1126–33. http://dx.doi.org/10.1177/1352458510374743.

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Background: Cognitive impairment is a common complication of multiple sclerosis, even in early stage disease, with significant impacts on life quality and social interaction. However, its detection is highly test-dependent. Objective: To validate a recently described screening tool, the ARCS, for detecting cognitive impairment in a multiple sclerosis population. Methods: The ARCS administers tests of executive function, memory, visual spatial construction and language via an audio device to unsupervised patients who write their responses for later scoring. Some 127 patients with a wide variety

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Hämäläinen, P., A. Ikonen, A. Romberg, H. Helenius, and J. Ruutiainen. "The effects of heat stress on cognition in persons with multiple sclerosis." Multiple Sclerosis Journal 18, no. 4 (2011): 489–97. http://dx.doi.org/10.1177/1352458511422926.

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Background: Heat sensitivity and cognitive deficits are typical manifestations of multiple sclerosis (MS). Although cognitive deficits are quite well characterized, practically no data exist on the effects of heat on cognitive performances in MS. Objective: To assess the effects of short-term heat stress on cognitive functioning in subjects with MS. Methods: A total of 23 heat-sensitive MS and 19 healthy control (HC) subjects participated. Moderate heat exposure took place in a Finnish sauna. Cognitive functioning was measured with tests of sustained attention and processing speed, the Paced A

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Rosti, E., P. Hämäläinen, K. Koivisto, and L. Hokkanen. "The PASAT performance among patients with multiple sclerosis: analyses of responding patterns using different scoring methods." Multiple Sclerosis Journal 12, no. 5 (2006): 586–93. http://dx.doi.org/10.1177/1352458506070624.

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The Paced Auditory Serial Addition Test (PASAT) is widely used in the evaluation of multiple sclerosis (MS) patients’ cognitive performance, and also used as the sole measure of cognition in a recently developed assessment tool for MS clinical trials, the Multiple Sclerosis Functional Composite (MSFC). We analysed if MS patients and healthy controls have different patterns of responding in the PASAT, and whether different scoring methods influence the PASAT’s sensitivity and specificity in detecting disease-associated cognitive impairment. Forty-five relapsing-remitting MS patients and 48 heal

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Strober, Lauren, John DeLuca, Ralph HB Benedict, et al. "Symbol Digit Modalities Test: A valid clinical trial endpoint for measuring cognition in multiple sclerosis." Multiple Sclerosis Journal 25, no. 13 (2018): 1781–90. http://dx.doi.org/10.1177/1352458518808204.

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Background: The need for more robust outcomes in multiple sclerosis (MS) clinical trials has been a main priority of the field for decades. Dissatisfaction with existing measures has led to several consensus meetings and initiatives over the past few decades in hopes of defining and gaining acceptance of measures that are valid, reliable, sensitive to change and progression, and most importantly, relevant to those living with MS. The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) was formed for this purpose. Objective: The objective of this paper is to describe the results of the MS

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Strober, Lauren, Nancy Chiaravalloti, Nancy Moore, and John DeLuca. "Unemployment in multiple sclerosis (MS): utility of the MS Functional Composite and cognitive testing." Multiple Sclerosis Journal 20, no. 1 (2013): 112–15. http://dx.doi.org/10.1177/1352458513488235.

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Unemployment is a significant concern among individuals with multiple sclerosis (MS). Determinations regarding ability to work are highly dependent on measurement tools used by neurologists and allied professionals. However, little is known of the usefulness of these tools when determining issues pertaining to employment status. The purpose of the present investigation was to examine the utility of the Multiple Sclerosis Functional Composite (MSFC) and a brief cognitive test battery when examining employment status in MS. Seventy-seven individuals with MS completed the MSFC and a brief cogniti

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Ozturk, A., SA Smith, EM Gordon-Lipkin, et al. "MRI of the corpus callosum in multiple sclerosis: association with disability." Multiple Sclerosis Journal 16, no. 2 (2010): 166–77. http://dx.doi.org/10.1177/1352458509353649.

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Inflammatory demyelination and axon damage in the corpus callosum are prominent features of multiple sclerosis (MS) and may partially account for impaired performance on complex tasks. The objective of this article was to characterize quantitative callosal MRI abnormalities and their association with disability. In 69 participants with MS and 29 healthy volunteers, lesional and extralesional callosal MRI indices were estimated via diffusion tensor tractography. expanded disability status scale (EDSS) and MS functional composite (MSFC) scores were recorded in 53 of the participants with MS. All

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Koprivnik, Matej, and Tanja Hojs Fabjan. "Clinical features in adult multiple sclerosis patients." Obzornik zdravstvene nege 54, no. 2 (2020): 104–12. http://dx.doi.org/10.14528/snr.2020.54.2.3016.

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Introduction: The purpose of the study was to identify possible correlations between the quality of life, neurological disability, and functional ability in patients with multiple sclerosis.Methods: 258 patients with multiple sclerosis were included in the cross-sectional study. They were assessed with the Expanded Disability Status Scale (EDSS), the Berg Balance Scale (BBS), the Timed 25-Foot Walk Test (T25-FW), the 9-Hole Peg Test (9HPT), the Paced Auditory Serial Addition Test (PASAT-3) and the EQ visual analogue scale (EQ-VAS). Inferential statistics were used.Results: A positive correlati

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Brenton, J. Nicholas, Hitoshi Koshiya, Emma Woolbright, and Myla D. Goldman. "The Multiple Sclerosis Functional Composite and Symbol Digit Modalities Test as outcome measures in pediatric multiple sclerosis." Multiple Sclerosis Journal - Experimental, Translational and Clinical 5, no. 2 (2019): 205521731984614. http://dx.doi.org/10.1177/2055217319846141.

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Background There is an increasing number of pediatric multiple sclerosis (MS) clinical trials occurring; however, data validating outcome metrics that accurately capture functional disability within pediatric cohorts are limited. Objective The aim of this study was to investigate the ability of the MS Functional Composite (MSFC) and Symbol Digit Modalities Test (SDMT) to distinguish functional disability in pediatric MS patients. Methods A total of 20 pediatric MS patients and 40 age and sex-matched controls completed the SDMT and MSFC components: a timed 25-foot walk (T25FW); 9-hole peg test

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Love, Heather L., Corilee A. Watters, and Wei-Ching Chang. "Meal Composition And Shift Work Performance." Canadian Journal of Dietetic Practice and Research 66, no. 1 (2005): 38–40. http://dx.doi.org/10.3148/66.1.2005.38.

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Research indicates that the ability to perform a task can be affected by the composition of the meal preceding the task. This study investigated the effect of shift workers’ consumption of a medium-fat, medium-carbohydrate meal on alertness scores. Six subjects (four men, two women) aged 19 to 44 recorded food intake, sleep, and quality of sleep for two weeks, and measured their body temperature and performed cognitive tests during two night shifts at baseline and in test periods. The Stanford Sleepiness Scale (SSS) was used to quantify sleepiness, and a Paced Auditory Serial Addition Test (PA

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Pravatà, Emanuele, Chiara Zecca, Carlo Sestieri, et al. "Hyperconnectivity of the dorsolateral prefrontal cortex following mental effort in multiple sclerosis patients with cognitive fatigue." Multiple Sclerosis Journal 22, no. 13 (2016): 1665–75. http://dx.doi.org/10.1177/1352458515625806.

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Objective: To investigate the dynamic temporal changes of brain resting-state functional connectivity (RS-FC) following mental effort in multiple sclerosis (MS) patients with cognitive fatigue (CF). Methods: Twenty-two MS patients, 11 with (F) and 11 without CF, and 12 healthy controls were included. Separate RS-FC scans were acquired on a 3T MR scanner immediately before ( t0), immediately after ( t1) and 30 minutes after ( t2) execution of the paced auditory serial addition test (PASAT), a cognitively demanding task. Subjectively perceived CF after PASAT execution was also assessed. RS-FC ch

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Claesson, Im, C. Ytterberg, S. Johansson, O. Almkvist, and L. Von Koch. "Rapid cognitive screening in multiple sclerosis accomplished by the Free Recall and Recognition Test." Multiple Sclerosis Journal 13, no. 2 (2007): 272–74. http://dx.doi.org/10.1177/1352458506071167.

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This study sought to investigate the feasibility of the Free Recall and Recognition Test (FRRT) as a practical screening tool for cognitive impairment in multiple sclerosis (MS). Persons with MS (n =227) were consecutively recruited and assessed with four cognitive tests; FRRT, Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test (PASAT), and the Mini-Mental State Examination (MMSE). Disease severity was assessed by the Expanded Disability Status Scale (EDSS). The FRRT, which was completed by 99% of the cohort in approximately 5 minutes per assessment, correlated significan

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Baltruschat, Sabina Anna, Noelia Ventura-Campos, Álvaro Javier Cruz-Gómez, Antonio Belenguer, and Cristina Forn. "Gray matter atrophy is associated with functional connectivity reorganization during the Paced Auditory Serial Addition Test (PASAT) execution in Multiple Sclerosis (MS)." Journal of Neuroradiology 42, no. 3 (2015): 141–49. http://dx.doi.org/10.1016/j.neurad.2015.02.006.

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Jansen, Petra, and Jennifer Lehmann. "Investigating Cognitive Performance Deficits in Male and Female Soccer Players after a 4-week Heading- Training Programme: A Controlled Study." Brain Impairment 19, no. 2 (2017): 133–40. http://dx.doi.org/10.1017/brimp.2017.4.

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This experimental study with a controlled pre-test and post-test group design investigated the possible effects of four sessions of heading training on cognitive performance. A total of 118 participants (mean age of 22.25 years) were assigned to one of the three following groups: a heading-training group, a passing-training group and a waiting control group. The participants completed a cognitive test battery of attention (D2-test), working memory (Paced Auditory Serial Addition Task, PASAT-2) and visual spatial intelligence (Mental Rotation Test) tests before, immediately after the second tra

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Drake, AS, B. Weinstock-Guttman, SA Morrow, D. Hojnacki, FE Munschauer, and RHB Benedict. "Psychometrics and normative data for the Multiple Sclerosis Functional Composite: replacing the PASAT with the Symbol Digit Modalities Test." Multiple Sclerosis Journal 16, no. 2 (2009): 228–37. http://dx.doi.org/10.1177/1352458509354552.

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The MS Functional Composite (MSFC) is a continuous scale of neurological disability for patients with multiple sclerosis (MS). Cognition is represented by the Paced Auditory Serial Addition Test (PASAT), although the Symbol Digit Modalities Test (SDMT) has been proposed as a promising alternative. MSFC scores were calculated using either the PASAT or the SDMT with the following reference populations: National Multiple Sclerosis Society (NMSS) Task Force, 400 MS patients, and 100 normal controls. A subgroup of 115 patients was followed longitudinally, with a test—retest interval of 2.3 ± 1.2 ye

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Bacon, Joshua H., Ilya Kister, Tamar E. Bacon, Eliana Pasternak, Yael Strauchler, and Joseph Herbert. "Sound Lateralization Test Distinguishes Unimpaired MS Patients from Healthy Controls." Multiple Sclerosis International 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/462043.

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There is an urgent need to develop a practical and reliable clinical measure of disease progression in early and mild MS. We hypothesized that a test of sound lateralization, which is exquisitely sensitive to transmission delays in auditory brainstem, could be more useful for detecting processing speed deficits in mildly impaired MS subjects than standard cognitive tasks.Objective. To develop a practical test of sound lateralization for the clinic and to compare performance of MS subjects with variable disability and healthy subjects on Sound Lateralization Test (SLT) and two speed-of-processi

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Sormani, Maria Pia, Nicola De Stefano, Gavin Giovannoni, et al. "Learning ability correlates with brain atrophy and disability progression in RRMS." Journal of Neurology, Neurosurgery & Psychiatry 90, no. 1 (2018): 38–43. http://dx.doi.org/10.1136/jnnp-2018-319129.

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ObjectiveTo assess the prognostic value of practice effect on Paced Auditory Serial Addition Test (PASAT) in multiple sclerosis.MethodsWe compared screening (day −14) and baseline (day 0) PASAT scores of 1009 patients from the FTY720 Research Evaluating Effects of Daily Oral therapy in Multiple Sclerosis (FREEDOMS) trial. We grouped patients into high and low learners if their PASAT score change was above or below the median change in their screening PASAT quartile group. We used Wilcoxon test to compare baseline disease characteristics between high and low learners, and multiple regression mo

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Yaldizli, Özgür, Iris-Katharina Penner, Karl Frontzek, et al. "The relationship between total and regional corpus callosum atrophy, cognitive impairment and fatigue in multiple sclerosis patients." Multiple Sclerosis Journal 20, no. 3 (2013): 356–64. http://dx.doi.org/10.1177/1352458513496880.

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Objective: The objective of this paper is to investigate the relationship between total and regional corpus callosum (CC) atrophy, neuropsychological test performance and fatigue in multiple sclerosis (MS) patients. Methods: We conducted a cross-sectional study in 113 MS patients: mean age 48±11 years, 75/113 women, 84/113 relapsing–remitting MS, mean disease duration 21±9 years, mean Expanded Disability Status Scale (EDSS) score 3.2±1.7. All patients underwent brain magnetic resonance imaging, standardised neurological assessment and comprehensive cognitive testing including assessments for f

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