Academic literature on the topic 'Paclitaxel (Taxol)'

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Journal articles on the topic "Paclitaxel (Taxol)"

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Rowinsky, Eric K., and Ross C. Donehower. "Paclitaxel (Taxol)." New England Journal of Medicine 332, no. 15 (1995): 1004–14. http://dx.doi.org/10.1056/nejm199504133321507.

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Kohler, David R., and Barry R. Goldspiel. "Paclitaxel (Taxol)." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 14, no. 1 (1994): 3–34. http://dx.doi.org/10.1002/j.1875-9114.1994.tb02785.x.

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Stull, Dean P., Thomas A. Scales, Randy Daughenbaugh, Neil A. Jans, and David T. Bailey. "Taxol® (Paclitaxel)." Applied Biochemistry and Biotechnology 54, no. 1-3 (1995): 133–40. http://dx.doi.org/10.1007/bf02787915.

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Faivre, Sandrine, Fran??ois Goldwasser, Patrick Souli??, and Jean-Louis Misset. "Paclitaxel (Taxol?? )-associated junctional tachycardia." Anti-Cancer Drugs 8, no. 7 (1997): 714–16. http://dx.doi.org/10.1097/00001813-199708000-00011.

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Martin, Virginia. "Overview of Paclitaxel (TAXOL®)." Seminars in Oncology Nursing 9, no. 4 (1993): 2–5. http://dx.doi.org/10.1016/s0749-2081(16)30035-3.

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Arbuck, Susan G., Andrew Dorr, and Michael A. Friedman. "Paclitaxel (Taxol) in Breast Cancer." Hematology/Oncology Clinics of North America 8, no. 1 (1994): 121–40. http://dx.doi.org/10.1016/s0889-8588(18)30191-6.

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Raymond, E., S. Cartier, C. Canuel, et al. "Extravasation de paclitaxel (Taxol®)." La Revue de Médecine Interne 16, no. 2 (1995): 141–42. http://dx.doi.org/10.1016/0248-8663(96)80679-5.

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Weaver, Beth A. "How Taxol/paclitaxel kills cancer cells." Molecular Biology of the Cell 25, no. 18 (2014): 2677–81. http://dx.doi.org/10.1091/mbc.e14-04-0916.

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Taxol (generic name paclitaxel) is a microtubule-stabilizing drug that is approved by the Food and Drug Administration for the treatment of ovarian, breast, and lung cancer, as well as Kaposi's sarcoma. It is used off-label to treat gastroesophageal, endometrial, cervical, prostate, and head and neck cancers, in addition to sarcoma, lymphoma, and leukemia. Paclitaxel has long been recognized to induce mitotic arrest, which leads to cell death in a subset of the arrested population. However, recent evidence demonstrates that intratumoral concentrations of paclitaxel are too low to cause mitotic
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Perry, J. R., and E. Warner. "Transient encephalopathy after paclitaxel (Taxol) infusion." Neurology 46, no. 6 (1996): 1596–99. http://dx.doi.org/10.1212/wnl.46.6.1596.

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Spiridonidis, C. H. "Paclitaxel (Taxol): A novel antineoplastic agent." Drugs of Today 29, no. 4 (1993): 295. http://dx.doi.org/10.1358/dot.1993.29.4.237522.

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Dissertations / Theses on the topic "Paclitaxel (Taxol)"

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Colony, James Lynn. "Studies on the biosynthesis of taxol /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/11587.

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Zhao, Zhiyang. "Studies on water-soluble taxol derivatives." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-11242009-020141/.

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Kreilein, Matthew M. "Progress toward the total synthesis of paclitaxel (taxol)." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1117063322.

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Targa, Benjamin. "Dialogue entre SEPT9_i1 et polyglutamylation de la tubuline : coopération dans la chimiorésistance aux taxanes et dans la localisation microtubulaire des filaments de septines." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS183.

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L’émergence de phénomènes de résistance au paclitaxel (Taxol®), un agent stabilisateur de microtubules (MTs), est un obstacle majeur au succès de cette molécule dans les chimiothérapies anticancéreuses et limite son utilisation. Au laboratoire, un nouveau mécanisme de résistance au Taxol® a été mis en évidence dans les cellules tumorales mammaires MDA-MB 231. Il est basé sur une restauration de la dynamique microtubulaire et implique i) deux modifications post-traductionnelles de la tubuline (MPTs), la détyrosination/retyrosination et la polyglutamylation et ii) la surexpression et la relocali
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Yang, Chao. "Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28942.

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Paclitaxel was isolated from the bark of <i>Taxus brevifolia</i> in the late 1960s. It exerts its biological effect by promoting tubulin polymerization and stabilizing the resulting microtubules. Paclitaxel has become one of the most important current drugs for the treatment of breast and ovarian cancers. Studies aimed at understanding the biologically active conformation of paclitaxel bound on β–tubulin are described. In this work, the synthesis of isotopically labeled taxol analogs is described and the REDOR studies of this compound complexed to tubulin agrees with the hypothesis that palic
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Chen, Ru. "Isolation, structure elucidation and approaches to the partial synthesis of new taxol analogs." Thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-11102009-020316/.

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Samaranayake, Gamini S. "Studies on the chemistry of taxol." Diss., Virginia Tech, 1992. http://hdl.handle.net/10919/39708.

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The novel diterpenoid taxol isolated from the western yew Taxus brevifolia is one of the most important lead compounds to emerge from the search for anticancer agents from plants. It shows consistent clinical activity against ovarian cancer and may also be active against other cancers. In this study, the preparation of various taxol derivatives was investigated, with the objective of better understanding the structural requirements for activity in the taxol series. The 7-hydroxyl group of taxol was derivatized with a photoaffinity label and other reagents as a beginning of the project to under
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Johnston, Jeffrey N. "Synthetic studies directed toward polycavernoside A and Taxol(RTM) (paclitaxel) /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487946103569429.

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Bourgeois, Damien. "Approche de synthèse du taxol : fermeture du cycle B par métathèse." Palaiseau, Ecole polytechnique, 2000. http://www.theses.fr/2000EPXX0032.

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Ce travail s'inscrit dans un projet du laboratoire dont l'objectif est la synthèse du taxol, un agent antitumoral naturel. Cette molécule présente un intérêt notable en raison de son squelette particulier et de la présence de nombreuses fonctions oxygénées. Une approche convergente reposant sur la fermeture du cycle b central a 8 chainons a été étudiée. A cet effet, un précurseur du cycle c a été synthétise, et son couplage par réaction de shapiro avec un aldéhyde précurseur du cycle a été étudié. La fermeture des divers séco-taxanes ainsi obtenus par réaction de métathèse a été inefficace. En
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Mangatal, Lydie. "Dérivés antitumoraux du taxol : hémisynthèse et relations structure-activité." Paris 11, 1989. http://www.theses.fr/1989PA112093.

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Le taxol, diterpène de type taxane, extrait difficilement des écorces de tronc de l'If (Taxus baccata L. ), est un "poison du fuseau mitotique" possédant un mode d'action unique sur la tubuline. Son hémisynthèse, ainsi que celle d'analogues structuraux a été entreprise à partir de la désacétyl-10baccatine III isolée des feuilles de l'If. L'hémisynthèse a été effectuée selon deux approches différentes. Une des voies fait intervenir une réaction d'hydroxyamination de Sharpless dont la sélectivité a été étudiée. L'activité biologique des analogues structuraux, ainsi que des intermédiaires d'hémis
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Books on the topic "Paclitaxel (Taxol)"

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I, Georg Gunda, American Chemical Society. Division of Chemical Health andSafety., American Chemical Society. Division of Medicinal Chemistry., and American Chemical Society. Division of Organic Chemistry., eds. Taxane anticancer agents: Basic science and current status : developed from symposia sponsored by the Divisions of Chemical Health and Safety, Medicinal Chemistry, and Organic Chemistry at the 207th National Meeting of the American Chemical Society, San Diego, California, March 13-18, 1994. The Society, 1995.

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Proceedings of the second National Cancer Institute Workshop on Taxol and Taxus: Held at Alexandria, Virginia, September 23-24, 1992. U.S. Dept. of Health and Human Services, Public Health Service, 1993.

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National Cancer Institute Workshop on Taxol and Taxus (2nd 1992 Alexandria, Va.). Proceedings of the second National Cancer Institute Workshop on Taxol and Taxus: Held at Alexandria, Virginia, September 23-24, 1992. U.S. Dept. of Health and Human Services, Public Health Service, National Cancer Institute, 1994.

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Office, General Accounting. Technology transfer: NIH-private sector partnership in the development of Taxol : report to the Honorable Ron Wyden, U.S. Senate. The Office, 2003.

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Steinberg, Ken. Effects of structural domains of Raf-1 on the sensitivity of MCF-7 breast cancer cells to Taxol (Paclitaxel). Laurentian University, School of Graduate Studies, 2005.

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Matthew, Suffness, ed. Taxol: Science and applications. CRC Press, 1995.

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C, Hansen Robert, and Ohio Agricultural Research and Development Center., eds. Taxus and Taxol: A compilation of research findings. Ohio State University, Ohio Agricultural Research and Development Center, 1999.

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Vittorio, Farina, ed. The chemistry and pharmacology of taxol and its derivatives. Elsevier, 1995.

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1944-, McGuire William P., and Rowinsky Eric K. 1956-, eds. Paclitaxel in cancer treatment. M. Dekker, 1995.

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Taxane Anticancer Agents: Basic Science and Current Status (Acs Symposium Series). Oxford University Press, USA, 1995.

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Book chapters on the topic "Paclitaxel (Taxol)"

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Casazza, Anna M., and Craig R. Fairchild. "Paclitaxel (Taxol®) Mechanisms of Resistance." In Drug Resistance. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-1267-3_6.

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"Taxol (Paclitaxel)." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_16716.

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May, Paul, and Simon Cotton. "Taxol (Paclitaxel)." In Molecules That Amaze Us. CRC Press, 2014. http://dx.doi.org/10.1201/b17423-57.

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"Taxol (Paclitaxel) and Cancer Chemotherapy." In Pharmacodynamic Basis of Herbal Medicine, Second Edition. CRC Press, 2006. http://dx.doi.org/10.1201/9781420006452.ch62.

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"Taxol (Paclitaxel) and Cancer Chemotherapy." In Pharmacodynamic Basis of Herbal Medicine. CRC Press, 2006. http://dx.doi.org/10.1201/9781420006452-68.

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"Taxol® (Paclitaxel) and Cancer Chemotherapy." In Pharmacodynamic Basis of Herbal Medicine. CRC Press, 2001. http://dx.doi.org/10.1201/9781420041781.ch55.

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"Taxol® (Paclitaxel) and Cancer Chemotherapy." In Pharmacodynamic Basis of Herbal Medicine. CRC Press, 2010. http://dx.doi.org/10.1201/9781420041781-59.

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Vyas, Dolatrai M. "3 Paclitaxel (taxol®) formulation and prodrugs." In Pharmacochemistry Library. Elsevier, 1995. http://dx.doi.org/10.1016/s0165-7208(06)80017-6.

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Taber, Douglass F. "The Sato/Chida Synthesis of Paclitaxel (Taxol®)." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0104.

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Paclitaxel (Taxol®) 3 is widely used in the clinical treatment of a variety of cancers. Takaaki Sato and Noritaka Chida of Keio University envisioned (Org. Lett. 2015, 17, 2570, 2574) establishing the central eight-membered ring of 3 by the SmI2-mediated cyclization of 1 to 2. The starting point for the synthesis was the enantiomerically-pure enone 5, pre­pared from the carbohydrate precursor 4. Conjugate addition to 5 proceeded anti to the benzyloxy substituent to give, after trapping with formaldehyde and protection, the ketone 6. Reduction and protection followed by hydroboration led to 7, that was, after protection and deprotection, oxidized to 8. The second ring of 3 was added in the form of the alkenyl lithium derivative 9, prepared from the trisylhydrazone of the corresponding ketone. Hydroxyl-directed epoxidation of 10 proceeded with high facial selectivity, leading, after reduction and protection, to the cyclic carbonate 11. Allylic oxidation converted the alkene into the enone, while at the same time oxidizing the benzyl protecting group to the ben­zoate, to give 12. Reduction of the ketone 12 led to a mixture of diastereomers. In practice, only one of the diastereomers of 1 cyclized cleanly to 2, as illustrated, so the undesired diastereomer from the NaBH4 reduction was oxidized back to the enone for recycling. For convenience, only one of the diastereomers of 2 was carried forward. To establish the tetrasubstituted alkene of 3, the alkene of 2 was converted to the cis diol and on to the bis xanthate 13. Warming to 50°C led to the desired tet­rasubstituted alkene, sparing the oxygenation that is eventually required for 3. For convenience, to intercept 16, the intermediate in the Takahashi total synthesis, both xanthates were eliminated to give 14. Hydrogenation removed the disubsti­tuted alkene, and also deprotected the benzyl ether. Oxidation followed by Peterson alkene formation led to 15, that was carried on to the Takahashi intermediate 16 using the now-standard protocol for oxetane construction. It is a measure of the strength of the science of organic synthesis that Masahisa Nakada of Waseda University also reported (Chem. Eur. J. 2015, 21, 355) an elegant synthesis of 3 (not illustrated).
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Chen, Shu-Hui, and Vittorio Farina. "5 Paclitaxel (Taxol®) chemistry and structure— Activity relationships." In Pharmacochemistry Library. Elsevier, 1995. http://dx.doi.org/10.1016/s0165-7208(06)80019-x.

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Conference papers on the topic "Paclitaxel (Taxol)"

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Ferrero, J.-M., A.-C. Hardy-Bessard, O. Capitain, et al. "Abstract P3-13-07: A-TaXel: Multicenter phase II combination of bevacizumab (A) with weekly paclitaxel (Ta) and capecitabine (Xel) in first line treatment for patients with triple negative metastatic or locally advanced breast cancer (TNMBC), a GINECO study." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-p3-13-07.

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Reports on the topic "Paclitaxel (Taxol)"

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Sikic, Branimir I. Paclitaxel (Taxol) Resistance in Breast Cancer Cells. Defense Technical Information Center, 1996. http://dx.doi.org/10.21236/ada326396.

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Sikic, Branimir I. Paclitaxel (Taxol) Resistance in Breast Cancer Cells. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada392688.

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Criswell, Tracy L., and David A. Boothman. Investigating the Role of Nuclear Clusterin (nCLU) in Lethality and Genomic Instability in Paclitaxel (Taxol) - Treated Human Breast Cancer Cells. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada418107.

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Criswell, Tracy L., and David A. Boothman. Investigating the Role of Nuclear Clusterin (nCLU) in Lethality and Genomic Instability in Paclitaxel (Taxol) - Treated Human Breast Cancer Cells. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada406785.

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