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Dissertations / Theses on the topic 'Paclitaxel (Taxol)'

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Published: 4 June 2021

Last updated: 5 February 2022

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1

Colony, James Lynn. "Studies on the biosynthesis of taxol /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/11587.

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2

Zhao, Zhiyang. "Studies on water-soluble taxol derivatives." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-11242009-020141/.

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3

Kreilein, Matthew M. "Progress toward the total synthesis of paclitaxel (taxol)." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1117063322.

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4

Targa, Benjamin. "Dialogue entre SEPT9_i1 et polyglutamylation de la tubuline : coopération dans la chimiorésistance aux taxanes et dans la localisation microtubulaire des filaments de septines." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS183.

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L’émergence de phénomènes de résistance au paclitaxel (Taxol®), un agent stabilisateur de microtubules (MTs), est un obstacle majeur au succès de cette molécule dans les chimiothérapies anticancéreuses et limite son utilisation. Au laboratoire, un nouveau mécanisme de résistance au Taxol® a été mis en évidence dans les cellules tumorales mammaires MDA-MB 231. Il est basé sur une restauration de la dynamique microtubulaire et implique i) deux modifications post-traductionnelles de la tubuline (MPTs), la détyrosination/retyrosination et la polyglutamylation et ii) la surexpression et la relocali

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5

Yang, Chao. "Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28942.

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Paclitaxel was isolated from the bark of <i>Taxus brevifolia</i> in the late 1960s. It exerts its biological effect by promoting tubulin polymerization and stabilizing the resulting microtubules. Paclitaxel has become one of the most important current drugs for the treatment of breast and ovarian cancers. Studies aimed at understanding the biologically active conformation of paclitaxel bound on β–tubulin are described. In this work, the synthesis of isotopically labeled taxol analogs is described and the REDOR studies of this compound complexed to tubulin agrees with the hypothesis that palic

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6

Chen, Ru. "Isolation, structure elucidation and approaches to the partial synthesis of new taxol analogs." Thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-11102009-020316/.

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7

Samaranayake, Gamini S. "Studies on the chemistry of taxol." Diss., Virginia Tech, 1992. http://hdl.handle.net/10919/39708.

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The novel diterpenoid taxol isolated from the western yew Taxus brevifolia is one of the most important lead compounds to emerge from the search for anticancer agents from plants. It shows consistent clinical activity against ovarian cancer and may also be active against other cancers. In this study, the preparation of various taxol derivatives was investigated, with the objective of better understanding the structural requirements for activity in the taxol series. The 7-hydroxyl group of taxol was derivatized with a photoaffinity label and other reagents as a beginning of the project to under

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8

Johnston, Jeffrey N. "Synthetic studies directed toward polycavernoside A and Taxol(RTM) (paclitaxel) /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487946103569429.

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9

Bourgeois, Damien. "Approche de synthèse du taxol : fermeture du cycle B par métathèse." Palaiseau, Ecole polytechnique, 2000. http://www.theses.fr/2000EPXX0032.

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Ce travail s'inscrit dans un projet du laboratoire dont l'objectif est la synthèse du taxol, un agent antitumoral naturel. Cette molécule présente un intérêt notable en raison de son squelette particulier et de la présence de nombreuses fonctions oxygénées. Une approche convergente reposant sur la fermeture du cycle b central a 8 chainons a été étudiée. A cet effet, un précurseur du cycle c a été synthétise, et son couplage par réaction de shapiro avec un aldéhyde précurseur du cycle a été étudié. La fermeture des divers séco-taxanes ainsi obtenus par réaction de métathèse a été inefficace. En

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10

Mangatal, Lydie. "Dérivés antitumoraux du taxol : hémisynthèse et relations structure-activité." Paris 11, 1989. http://www.theses.fr/1989PA112093.

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Le taxol, diterpène de type taxane, extrait difficilement des écorces de tronc de l'If (Taxus baccata L. ), est un "poison du fuseau mitotique" possédant un mode d'action unique sur la tubuline. Son hémisynthèse, ainsi que celle d'analogues structuraux a été entreprise à partir de la désacétyl-10baccatine III isolée des feuilles de l'If. L'hémisynthèse a été effectuée selon deux approches différentes. Une des voies fait intervenir une réaction d'hydroxyamination de Sharpless dont la sélectivité a été étudiée. L'activité biologique des analogues structuraux, ainsi que des intermédiaires d'hémis

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11

Baloglu, Erkan Jr. "A New Synthesis of Taxol®, from Baccatin III." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/36930.

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Taxol®, an important anticancer drug, was first isolated in extremely low yield from the bark of the western yew, Taxus brevifolia. The clinical utility of Taxol has prompted a tremendous effort to obtain this complex molecule synthetically. Due to the chemical complexity of Taxol, its commercial production by total synthesis is not likely to be economical. Another natural product, 10-deacetyl baccatin III, is readily available in higher yield. Several methods have been reported for the synthesis of Taxol by coupling baccatin III and the N-benzoyl-β-phenylisoserine side chain. A new method

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12

Baloglu, Erkan. "Synthesis and Biological Evaluation of Paclitaxel Analogs." Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/27853.

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The complex natural product paclitaxel (TaxolÂ®), first isolated from Taxus brevifolia, is a member of a large family of taxane diterpenoids. Paclitaxel is extensively used for the treatment of solid tumors, particularly those of the breasts and ovaries. In order to obtain additional information about the mechanism of action of paclitaxel and the environment of the paclitaxel-binding site, several fluorescent analogs of paclitaxel were synthesized, and their biological activities have been evaluated. For the investigation of possible synergistic effects, concurrent modifications on sele

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13

Hodge, Mathis. "Synthesis and Antiproliferative Activity of C3' and B-ring Modified Paclitaxel Analogs." Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/30940.

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The natural product, paclitaxel, has made tremendous contributions in supplying the arsenal of anticancer therapeutics, and was FDA approved for clinical use in 1992. In order to design simplified analogs, the conformation that paclitaxel adopts when binding to tubulin has been the subject of ongoing studies. Much evidence has led to a T-taxol proposal and a C3' constrained analog has been designed and synthesized as a test of this conformation. In the search for more active analogs, a number of modifications have been made to paclitaxel by other researchers. However, the nature of the alterat

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14

Vandana, Vishnu. "Separation of taxol and related taxanes using supercritical fluids." Diss., Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/10078.

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15

Schmitz, Michael. "Antiproliferative Effekte von Paclitaxel (Taxol) auf humane Nierenzellkarzinomzelllinien und der Multidrug-Resistenz-Phänotyp." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=971028532.

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16

Tsai, Max Chia-Shin. "Biodegradable paclitaxel-loaded plga microspheres for regional treatment of peritoneal cancers." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1066335356.

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17

Kröhne, Lutz. "Untersuchungen zur Anwendbarkeit von Polyelektrolytmultischichten für Drug-Eluting Stents zur lokalen Freisetzung von Paclitaxel." kostenfrei, 2009. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1289/.

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18

Cardoso, Mirlane Guimarães de Melo. "Efeito potencializador do antineoplásico paclitaxel (taxol®) na hiperalgesia inflamatória experimental induzida por zymosan." reponame:Repositório Institucional da UFC, 2003. http://www.repositorio.ufc.br/handle/riufc/2582.

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CARDOSO, Mirlane Guimarães de Melo. Efeito potencializador do antineoplásico paclitaxel (TAXOL) na hiperalgesia inflamatória experimental induzida por zymosan. 2003. 127 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2003.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-05-07T13:49:25Z No. of bitstreams: 1 2003_dis_mgmcardoso.pdf: 948719 bytes, checksum: 74fac9ee50502a1b6865c0976f5275ed (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-05-08T16:52:41Z (GMT) No. of bitstreams: 1

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19

Lamotte, Yann. "Design, synthèse et évaluation biologique de mimes du paclitaxel dérivés de la proline." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066608/document.

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Parmi les nombreux agents thérapeutiques utilisés en oncologie, le paclitaxel (Taxol®) est sans doute celui qui a suscité le plus d'intérêt. Il est utilisé en clinique pour le traitement des cancers de l'ovaire, du sein et des poumons. Il agit comme poison du fuseau mitotique en favorisant l'assemblage de la tubuline en microtubules et en stabilisant le polymère formé. Initialement extrait de l'if du Pacifique (Taxus Brevifolia) puis obtenu par hémisynthèse à partir de la 10-déacétylbaccatine III, il est aujourd'hui produit par un procédé biotechnologique de fermentation de cellules végétales.

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20

Aouzal, Rémi. "Vers la synthèse du tricycle ABC du Taxol." Phd thesis, Ecole Polytechnique X, 2010. http://pastel.archives-ouvertes.fr/pastel-00516141.

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Au cours de cette thèse, nous avons cherché à appliquer la réaction de métathèse des oléfines pour synthétiser le tricycle ABC du taxol, une molécule naturelle issue de l'if de l'ouest dans les années 1960. Nous avons pour cela étudié deux rétrosynthèses: - la première s'appuie sur la fermeture du cycle B à huit chaînons par une métathèse relais cyclisante. - la seconde repose sur une métathèse tandem ène-yne-ène permettant la formation en une seule étape des cycles A et B.

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21

Estrache, Marc. "Du "Taxus" à la 10-désacétylbaccatine III : matière première d'hémisynthèse." Paris 5, 1994. http://www.theses.fr/1994PA05P109.

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22

Zhao, Jielu. "Design, Syntheses and Biological Activities of Paclitaxel Analogs." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/77272.

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The conformation of paclitaxel in the bound state on the protein has been proposed to be the T-taxol conformation, and paclitaxel analogs constrained to the T-taxol conformation proved to be significantly more active than paclitaxel in both cytotoxicity and tubulin polymerization assays, thus validating the T-taxol conformation as the tubulin-binding conformation. In this work, eight compounds containing an aza-tricyclic moiety as a mimic of the baccatin core of paclitaxel have been designed and synthesized as water-soluble simplified paclitaxel analogs, among which 3.50-3.52 and 3.55 were con

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23

Peronne, Lauralie. "Caractérisation d'un nouveau composé pharmacologique qui potentialise la réponse des cellules au paclitaxel (Taxol®)." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAV003.

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Les agents pharmacologiques ciblant la dynamique des microtubules (MTs) sont très utilisés en chimiothérapie des cancers agressifs. Le paclitaxel (PTX) est utilisé depuis des décennies et donne de bons résultats pour le traitement des tumeurs solides. Plusieurs inconvénients, notamment ses effets secondaires et la résistance de certains cancers limitent cependant l'efficacité de ce médicament. Dans le but d'identifier de nouveaux composés pharmacologiques qui sensibilisent les cellules au PTX, nous avons recherché, parmi une collection de 8000 molécules, celles capables de sensibiliser des cel

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24

Lian, Yiqian. "Chromium and iron organometallics in organic synthesis synthetic studies toward total synthesis of taxol and chromium to iron transfer processes /." Diss., Connect to online resource - MSU authorized users, 2006.

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25

Chau, Mydoanh. "Molecular cloning and characterization of three enzymes involved in Taxol/Taxoid biosynthesis Taxoid 2[alpha]-hydroxylase, Taxoid 7[beta]-hydroxylase, and Taxoid 5[alpha]-O-Acetyl transferase /." Online access for everyone, 2004. http://www.dissertations.wsu.edu/Dissertations/Spring2004/M%5FChau%5F041404.pdf.

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26

Gonçalves, Anthony. "Mécanismes d'action du taxol et modes de résistances spécifiques : études cellulaires de l'apoptose et de la dynamique microtubulaire." Aix-Marseille 2, 2001. http://theses.univ-amu.fr.lama.univ-amu.fr/2001AIX20677.pdf.

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Les agents antimicrotubules représentent une importante classe d'agents anticancéreux largement utilisés en oncologie. Ces composés peuvent initier le phénomène de mort cellulaire programmée ou apoptose. Nous avons étudié l'apoptose induite par le taxol® et les autres agents antimicrotubules au niveau de la lignée humaine de cancer colique HT29-D4. Nous avons montré que ce phénomène était conditionné par un blocage préalable des cellules en phase G2/M, associé à une phosphorylation de la molécule anti-apoptotique Bcl-Xl. Nous avons montré que la caspase-8, un composant central de la voie CD95,

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27

Vieillemaringe, Sandrine. "L'if et son utilisation en cancérologie." Bordeaux 2, 1995. http://www.theses.fr/1995BOR2P041.

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28

Walker, Kevin D. "The use of stereospecifically-labeled phenylpropanoid compounds to determine the steric course of key reaction steps in the biosynthesis of taxol, hyoscyamine, and cycloheptyl fatty acids /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/8662.

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29

Reinkensmeier, Bianka [Verfasser]. "Reokklusionsprophylaxe mittels Paclitaxel (Taxol®)-beschichteter Angioplastie-Ballonkatheter bei arteriosklerotisch bedingten Stenosen und Okklusionen der femoropoplitealen Arterien / Bianka Reinkensmeier." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1104170507/34.

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30

Froidevaux-Klipfel, Laurence. "Implication des septines recrutées sur les microtubules tyrosinés et polyglutamylés dans la résistance au taxol de cellules cancéreuses mammaires MDA-MB 231." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA114850/document.

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Le cancer du sein est une cause importante de mortalité féminine en France et l’émergence de chimiorésistance, en particulier avec les taxanes, dont le paclitaxel (Taxol®), est une limite importante à l’emploi de ces molécules. Comme de nombreux anticancéreux, les taxanes ciblent les microtubules (MTs), des polymères de tubuline intervenant dans de nombreuses fonctions cellulaires. Ces derniers alternent entre des phases de croissance et de désassemblage, leur conférant ainsi un caractère dynamique. En se liant à la beta-tubuline, le Taxol stabilise les MTs et bloque la mitose, conduisant la c

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31

Green, Henrik. "Pharmacogenetic Studies of Paclitaxel in Ovarian Cancer : focus on interindividual differences in pharmacodynamics and pharmacokinetics." Doctoral thesis, Linköpings universitet, Klinisk farmakologi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8134.

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Ovarian cancer is one of the most common female cancer diseases in the world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. The response to treatment and the severity of adverse drug reactions after chemotherapy varies greatly among individuals, and one of the most important factors responsible for these differences is now recognized to be the genetic variability. One of the major obstacles to successful treatment is drug resistance. Severa

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32

Zanville, Noah Robert. "Evaluating Local Skin Heating as an Early Detection Method for Small-fiber Neuropathy in Women with Breast Cancer Receiving Paclitaxel (Taxol(RTM))." Thesis, Indiana University - Purdue University Indianapolis, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10839712.

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<p> The purpose of this prospective, observational study was to determine if a technique used to detect early signs of small-fiber neuropathy (local skin heating) could detect signs of small-fiber taxane-induced peripheral neuropathy (TIPN) in breast cancer survivors (BCS) during the first 6 weeks of Taxol<sup>®</sup>. Aims of the study were to compare the mean size of (1) axon reflexes and (2) axon flares (both markers of small-fiber nerve function) in BCS receiving Taxol<sup>®</sup> to the size of reflexes/flares in healthy female controls (HCs). A third aim was to determine whether

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33

Qi, Jun. "Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/37537.

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Prostate cancer is the most common non-skin cancer for men in America. The androgen receptor exerts transcriptional activity and plays an important role for the proliferation of prostate cancer cells. Androgen receptor ligands bind the androgen receptor and inhibit its transcriptional activity effectively. However, prostate cancer can progress to hormone refractory prostate cancer (HRPC) to avoid this effect. Chemotherapies are currently the primary treatments for HRPC. Unfortunately, none of the available chemotherapies are curative. Among them, paclitaxel and docetaxel are two of the most ef

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34

CHADEBECH, PHILIPPE. "Activation de points de controle du cycle cellulaire en mitose et induction d'apoptose lors du traitement de cellules tumorales par le paclitaxel (taxol)." Toulouse 3, 1999. http://www.theses.fr/1999TOU30186.

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Le paclitaxel est un agent anticancereux dont l'activite cytotoxique resulte de sa capacite a stimuler l'assemblage des microtubules et a inhiber leur depolymerisation. Ces dommages activent un point de controle du cycle cellulaire qui bloque la progression des cellules en mitose. Au bout d'un certain temps, ces cellules vont soit mourir par apoptose soit echapper a ce blocage et evoluer vers un phenotype de cellules plurinucleees. Nous avons etudie les interconnections entre le point de controle du cycle en mitose et l'apoptose induits par le paclitaxel. Nos resultats indiquent que le blocage

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35

Jost, Sylvie. "Nouvelles stratégies pour la synthèse des chaines latérales du Taxol(R)(paclitaxel) et du Taxotère(R)(docétaxel) : couplage imine, aldéhyde et couplage nitrone, acétal de cétène." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10265.

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Le taxol# et le taxotere# sont deux composes anticancereux parmi les plus efficaces a l'heure actuelle. L'hemisynthese est actuellement la methode de choix pour preparer ces deux molecules. Elle fait intervenir un precurseur naturel abondant dont l'extraction des feuilles d'ifs est sans danger pour l'espece, et une chaine laterale synthetique. Les travaux de notre laboratoire, orientes principalement vers la recherche de nouvelles strategies de synthese de ces chaines laterales syn (2r,3s), ont montre qu'il etait possible de realiser l'esterification entre le precurseur naturel et une chaine s

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36

El, Kadiri Hanae. "Mise en évidence de l'activité antitumorale du taxol au moyen de tests in vitro sur cellules humaines : cancers bronchiques à petites cellules (lignée NCI-N 417), de l'ovaire et du sein." Université Joseph Fourier (Grenoble), 1988. http://www.theses.fr/1988GRE18002.

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37

Lam, Polo Chun Hung. "Experimental and Computational Studies in Bioorganic and Synthetic Organic Chemistry." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/40013.

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Cationâ Ï interaction is an important determinant in protein structure and function. Among the three proteinogenic aromatic amino acids, tryptophan (Trp) is the strongest cationâ Ï donor. We reported the asymmetric syntheses of tryptophan regioisomers in which the amino acid side chain is attached at different position of the indole moiety. These new tryptophan regioisomers can effect a different mode of cationâ Ï interaction. In nature, dramatic increases in binding affinity can be achieved through multivalent binding. Following a fragmentation-dimerization approach, we synthesized

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38

Kanazawa, Alice Misa. "Nouvelles synthèses de chaînes latérales du taxotère et du taxol et synthèses du (+ou-)- et (-)-homogynolide-A." Grenoble 1, 1994. http://www.theses.fr/1994GRE10008.

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Le taxol et le taxotere sont deux composes qui presentent des activites antitumorales assez remarquables contre plusieurs types de cancers. La synthese partielle en utilisant un produit naturel abondant et les chaines laterales correspondantes est la strategie de choix actuelle pour l'obtention de facon efficace de ces deux composes. Un des interets majeurs du laboratoire consiste a trouver de nouvelles methodes de synthese de ces chaines (surtout du taxotere) sous forme enantiomeriquement pure. Au cours de ce travail nous avons effectue, dans un premier temps, une synthese courte et directe (

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39

Mulamba, Peter. "Biomaterials Modeling Of Localized Hyperthermia And Drug Delivery For Breast Cancer." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1229981884.

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40

Yuan, Haiqing Jr. "Studies on the Chemistry of Paclitaxel." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/30671.

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Paclitaxel is a natural occurring diterpene alkaloid originally isolated from the bark of Taxus brevifolia. It is now one of the most important chemotherapeutic agents for clinical treatment of ovarian and breast cancers. Recent clinical trials have also shown paclitaxel's potential for the treatment of non-small-cell lung cancer, head and neck cancer, and other types of cancers. While tremendous chemical research efforts have been made in the past years, which established the fundamental structure-activity relationships of the paclitaxel molecule, and provided analogs for biochemical studies

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41

Cardoso, Mirlane GuimarÃes de Melo. "Efeito potencializador do antineoplÃsico paclitaxel (taxolÂ) na hiperalgesia inflamatÃria experimental induzida por zymosan." Universidade Federal do CearÃ, 2003. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=109.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>nÃo hÃ<br>Paclitaxel(TaxolÂ), foi o 1Â antineoplÃsico efetivo no tratamento de cÃnceres refratÃrios a quimioterapia convencional. Clinicamente, induz mielossupressÃo e neuropatia perifÃrica sensorial dose-limitante e cumulativa, jÃ bem documentada na literatura. Menos freqÃentemente os pacientes tratados apresentam mialgias e artralgias. No que diz respeito Ã dor inflamatÃria, nada foi descrito atÃ o momento, visando correlacionar o envolvimento das citocinas prÃ-inflamatÃrias, com a gÃnese da hiperalgesia associada ao PCX, jÃ qu

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42

"Synthesis of pseudo-AB ring analogues of taxol." 2003. http://library.cuhk.edu.hk/record=b6073595.

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Lee Chi-man.<br>"July 2003."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2003.<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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43

Zhang, Jun. "Degradation kinetics of taxol using mass spectroscopy." Thesis, 2005. http://hdl.handle.net/1957/586.

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Paclitaxel is a very important anticancer drug commonly called Taxol®. We know from previous work (Hoffman, et al., 1998) that Taxol exists in filbert, Corylus avellana L. material. Quantification of Taxol in filbert plant material is painstaking and hitherto was accomplished by rapidly processing single batches in a complicated procedure (Hoffman, et al., 1998), which seemingly unavoidably, was accompanied by some degradation. However for extraction, testing, plant physiological and horticultural purposes a simplified method of determining Taxol yield is required. All simplified methods te

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44

Joud, Carol Holton Robert Anthony. "Towards a new pathway for synthesis of taxol and its analogs." Diss., 2005. http://etd.lib.fsu.edu/theses/available/etd-11152005-144557.

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Thesis (M.S.)--Florida State University, 2005.<br>Advisor: Robert A. Holton, Florida State University, College of Arts and Sciences, Dept. of Chemistry. Title and description from dissertation home page (viewed Jan. 26, 2006). Document formatted into pages; contains xii, 196 pages. Includes bibliographical references.

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Allison, Jeffrey Corbin. "Studies directed towards the total synthesis of the natural product Taxol." 2003. http://wwwlib.umi.com/cr/utexas/fullcit?p3119656.

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Shanker, Natasha. "Unraveling the interactions of anti-mitotic agents Taxol and epothilones with microtubules using spectroscopic tools." 2007. http://wwwlib.umi.com/cr/binghamton/main.

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Hunz, Miriam. "Plasma- und Gewebspharmakokinetik von Epirubicin und Paclitaxel unter neoadjuvanter Chemotherapie bei Patientinnen mit primärem Mammakarzinom /." 2002. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=010626836&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Samadi, Nasser. "Autotaxin, lysophosphatidate and taxol resistance." Phd thesis, 2009. http://hdl.handle.net/10048/681.

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Thesis (Ph.D.)--University of Alberta, 2009.<br>A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Medical Sciences, Laboratory Medicine and Pathology. Title from pdf file main screen (viewed on October 31, 2009). Includes bibliographical references.

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Butt, Krista. "An assessment of taxol-Induced apoptosis in MCF-7 and MDA-MB-231 human breast adenocarcinoma cells /." 2004.

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Fuertes, Michael Joseph. "Synthetic studies towards taxol : the reaction between Fischer carbene complexes and chiral dienynes /." 2002. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3039028.

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