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Journal articles on the topic 'Paederosidic acid'

Author: Grafiati

Published: 5 June 2025

Last updated: 24 June 2025

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1

D., N. Singh, and Verma N. "Iridoid glucosides and anthraquinone from the aerial parts of Saprosma fragrans." Journal of Indian Chemical Society Vol. 89, Mar 2012 (2012): 429–31. https://doi.org/10.5281/zenodo.5760363.

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Department of Chemistry, K. S. Saket P.O. College, Dr. Ram Manohar Lohia Avadh University, Faizabad-224 001, Uttar Pradesh, India <em>E-mail</em> : dnsinghsaket@yahoo.com <em>Manuscript received 10 March 2011, accepted 20 June 2011</em> Paederoside, paederosidic acid, 1,3-dimethoxyanthraquinone-2-carboxylic acid and β-sitosteroi-D-glucoside have been isolated from the ethanolic extract of the aerial parts of <em>Saprosma fragrans</em> and their structures were established by spectral evidences and chemical studies. This is the first report of iridoid glucosides, paederoside and paederosidic acid containing rarely encountered S-methyl thiocarbonate moiety, 1 ,3-dimethoxyanthraquinone-2-carboxylic acid and β-sitosterol-D-glucoside in <em>S. fragrarzs</em>. The identities of isolated iridoid glucosides were also verified by detailed spectral data (UV, IR, FAB-MS, <sup>1</sup>H NMR and <sup>13</sup>C NMR) analyses of acetate derivatives of paederoside and paederosidic acid prepared by the acetylation of the respective iridoid glucosides.

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2

Xie, Yanxiang, Ergang Jiang, Tianming Dai, and Renke Dai. "Simultaneous Determination of Four Iridoid Glycosides from Paederia Scandens in Rat Plasma by LC-MS/MS and its Application to a Pharmacokinetic Study." Current Analytical Chemistry 16, no. 3 (2020): 298–307. http://dx.doi.org/10.2174/1573411014666180907152359.

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Background: Paederia scandens (Lour.) Merrill, belonging to the Rubiaceae family, was one of the Traditional Chinese Medicines that has been generally used to treat aches and pains, inflammation, bacillary dysentery, piles and rheumatic arthritis. The four iridoid glycosides that Paederosidic acid, Paederoside, Paederosidic acid methyl ester, and Asperuloside from Paederia scandens are considered to be the main bioactive constituents. However, their pharmacokinetics and action mechanisms of these iridoid glycosides still remain unknown. In this study, a method of simultaneous determination of four iridoid glycosides components in rat plasma with LC-MS/MS has been established and successfully applied to a pharmacokinetic study in rats, which would be favourable for further exploration. Methods: In this study, a sensitive, rapid, accurate bioanalytical method of simultaneous determination of four iridoid glycosides components from Paederia scandens extract in rat plasma with LCMS/ MS has been established. It is easy and rapid for LC-MS/MS to accurately separate and simultaneously quantify the analytes because of its high sensitivity, selectivity and accuracy. This validated method was successfully applied to a pharmacokinetic study in rats with intravenous and oral administrations of Paederia scandens extract. Results: The resulting data are fully satisfied for the selectivity and the sensitivity. Their lower limit of quantitation are in 0.25-0.5 ng/mL. Intra- and interday precisions were less than 15.0% with accuracy in the range of -15.0% to 15.0%. In the stability measurements including repeated Freeze-thaw, 4 hours at 4°C, 24 hours at 4°C, and 30 days at -80°C, the variations between the measurements and the nominated values of these compounds in plasma were detected to be less than 15.0%. The extraction recoveries of the compounds were from 85.4% to 105.6%. The bioavailability (F) of the four iridoid glycosides were 1.74% to 3.36%. Conclusion: In summary, a simple, rapid, precise, and sensitive LC-MS/MS method has been established and validated to determine the four iridoid glycosides from Paederia scandens extract in rat plasma, which was successfully applied to pharmacokinetic study in rats. The information obtained from the study will facilitate further exploration on Paederosidic acid, Paederoside, Paederosidic acid methyl ester as well as Asperuloside and these may provide valuable pharmacokinetic reference for human applications.

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3

Chen, Yu-Feng, Dian-Hua Liu, Qiong Wu, et al. "Possible Mechanism Involved in the Antinociceptive Activity of Dimer of Paederosidic Acid and Paederosidic Acid Methyl Ester in Mice." CNS Neuroscience & Therapeutics 20, no. 2 (2013): 188–90. http://dx.doi.org/10.1111/cns.12215.

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4

Tao, Zhou-Shan, Xu-Feng Hu, Xing-Jing Wu, Min Yang, and Wen Sun. "Paederosidic acid protect bone mass in lipopolysaccharide-treated rats by reducing oxidative stress and inflammatory." International Immunopharmacology 143 (December 2024): 113420. http://dx.doi.org/10.1016/j.intimp.2024.113420.

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5

Li, Yuxin, Yehong Li, Yifan Zhu, et al. "Structure-based virtual screening for discovery of paederosidic acid from Paederia scandens as novel P2Y14R antagonist." Phytomedicine 115 (July 2023): 154851. http://dx.doi.org/10.1016/j.phymed.2023.154851.

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6

Yang, Tao, Bin Kong, Jian-Wen Gu, et al. "Anticonvulsant and sedative effects of paederosidic acid isolated from Paederia scandens (Lour.) Merrill. in mice and rats." Pharmacology Biochemistry and Behavior 111 (October 2013): 97–101. http://dx.doi.org/10.1016/j.pbb.2013.08.015.

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7

Chen, Yu-Feng, Ying Huang, Wei-Zhong Tang, Lu-Ping Qin, and Han-chen Zheng. "Antinociceptive activity of Paederosidic Acid Methyl Ester (PAME) from the n-butanol fraction of Paederia scandens in mice." Pharmacology Biochemistry and Behavior 93, no. 2 (2009): 97–104. http://dx.doi.org/10.1016/j.pbb.2009.04.016.

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8

Yu, Ping, Lifeng Shi, Meiyan Song, and Yu Meng. "Antitumor activity of paederosidic acid in human non-small cell lung cancer cells via inducing mitochondria-mediated apoptosis." Chemico-Biological Interactions 269 (May 2017): 33–40. http://dx.doi.org/10.1016/j.cbi.2017.02.003.

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9

Chen, L., R. Zeng, and Y. Zhuang. "In vitro Anti-Gastric Tumor Activities and Possible Mechanisms of Action of Paederosidic Acid from Paederia scandens (Lour) Merrill." Tropical Journal of Pharmaceutical Research 14, no. 5 (2015): 795. http://dx.doi.org/10.4314/tjpr.v14i5.8.

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10

Frezza, Claudio, Alessandro Venditti, Daniela De Vita, Marcella Guiso, and Armandodoriano Bianco. "Bis-Iridoids: Occurrence, Chemophenetic Evaluation and Biological Activities—A Review." Molecules 29, no. 23 (2024): 5646. http://dx.doi.org/10.3390/molecules29235646.

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In this work, the first review paper about bis-iridoids was presented. In particular, their detailed occurrence, chemophenetic evaluation and biological activities were reported. To the best of our knowledge, two hundred and eighty-eight bis-iridoids have been evidenced so far, bearing different structural features, with the link between two seco-iridoids sub-units as the major one. Different types of base structures have been found, with catalpol, loganin, paederosidic acid, olesoide methyl ester, secoxyloganin and loganetin as the major ones. Even bis-irdioids with non-conventional structures like intra-cyclized and non-alkene six rings have been reported. Some of these compounds have been individuated as chemophenetic markers at different levels, such as cantleyoside, laciniatosides, sylvestrosides, GI-3, GI-5, oleonuezhenide, (Z)-aldosecologanin and centauroside. Only one hundred and fifty-nine bis-iridoids have been tested for their biological effects, including enzymatic, antioxidant, antimicrobial, antitumoral and anti-inflammatory. Sylvestroside I was the compound with the highest number of biological tests, whereas cantleyoside was the compound with the highest number of specific biological tests. Bis-iridoids have not always shown activity, and when active, their effectiveness values have been both higher and lower than the positive controls, if present. All these aspects have been deeply discussed in this paper, which also shows some critical issues and even suggests possible arguments for future research, since there is still a lot unknown about bis-iridoids.

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11

Tuan, Hoang Quoc, Hoang Ngoc Phuong Vy, Nguyen Thi Anh Thu, and Phan Le Nhu Quynh. "Potential Molecular Mechanisms of Paederia Foetida L. In Gout Treatment Through Network Pharmacology And Molecular Docking." EuroBiotech Journal 9, no. 2 (2025): 138–53. https://doi.org/10.2478/ebtj-2025-0012.

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Abstract The global incidence of gout has been steadily increasing. Paederia foetida L., a traditional medicine, is used to treat gout in Vietnam, though its active compounds’ molecular mechanisms remain uncertain. This study used network pharmacology and molecular docking to predict the potential targets and pathways of P. foetida bioactive components in gout treatment, providing insights for clinical applications. Compounds and targets of P. foetida were identified using the TCMSP database, while targets associated with gout were obtained from GeneCards, TTD, and OMIM databases. A Venn diagram was employed to determine the common targets, and Cytoscape software was used to construct the compound-target-pathway interaction network. GO and KEGG enrichment analyses were performed to identify key biological processes and pathways. AutoDockTools was used to verify molecular docking between active compounds of P. foetida and core targets. Five active compounds and 49 common targets were identified. GO enrichment analysis revealed that P. foetida influenced multiple biological processes, cellular components, and molecular functions. KEGG analysis elucidated that the primary mechanism of P. foetida in gout treatment may be primarily related to the IL-17 signaling pathway and several other anti-inflammatories signaling pathways. Molecular docking confirmed strong binding (affinity < -5 kcal/mol) between five active compounds and core protein targets, including TP53, IL6, HSP90AA1, TNF, IL1B, BCL2, PTGS2, MAPK1, and MAPK8. Among the targets, the docking scores of MAPK8 (7.2-10.1 kcal/mol) were the best. Active compounds such as quercetin, beta-sitosterol, kaempferol, pelargonidin, and paederosidic acid methyl ester exhibited potential therapeutic effects on gout. Through in silico screening, the mechanism of action of P. foetida in treating gout can be determined to act on multiple targets through multiple pathways. This provides more ideas for in vitro and in vivo experiments to develop herbal medicines for gout treatment.

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12

Li, Yuxin, Yifan Zhu, Yehong Li, et al. "Structure-Based Virtual Screening for Discovery of Paederosidic Acid from Paederia Scandens as Novel P2Y14R Antagonist." SSRN Electronic Journal, 2023. http://dx.doi.org/10.2139/ssrn.4373059.

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13

Dwivedi, Jyotsana, Pranay Wal, Vijay D. Wagh, et al. "Paederia Foetida Linn (Rubiaceae): Chemical Diversity, Phytopharmacological Potential, Quantitative Analysis and Clinical Approaches." Combinatorial Chemistry & High Throughput Screening 28 (January 7, 2025). https://doi.org/10.2174/0113862073314773241115100620.

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Abstract: The discovery of novel counteractive pharmaceuticals, which have recently generated much interest, has played a significant role in the development of drugs derived from herbal medicines or botanical sources. Paederia foetida (P. foetida) is one such example of a role in both traditional and traditional medicine. Owing to its popularity in folk medicine, it has been the subject of intense pharmacological and chemical studies for the last 30 years. They are locally known as "Gandhavadulia" or "GandhaPrasarini" (English name "skunkvine") and belong to the family Rubiaceae. This plant has a broad range of applications in the treatment of several illnesses, including anti-inflammatory, antinociceptive, antitussive, thrombolytic, antidiabetic, antihyperlipidaemic, antioxidant, nephroprotective, anti-inflammatory, hepatoprotective, anthelmintic, and antidiarrheal effects. Additionally, it contains a variety of phytochemicals, such as asperuloside, paederosidic acid, sitosterols, campesterol, lignans, alkaloids, volatile oils, iridoids, methylindooxy substances, stigmasterol, tannins, triterpenoids, ellagic acid, ursolic acid, epifriedelinol, and phenolic compounds. Recently, mounting data on numerous active ingredients have indicated that they may be beneficial for spermatogenesis, wound healing, inflammatory illnesses, and cancer. This review describes the phytochemistry and mechanisms of action of these pharmacological effects and provides insights into potential pharmacological targets. These results highlight the need for additional studies on this medicinal plant and the investigation of new counteractive medications to determine their mode of action before use in healthcare.

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14

Barai, Samir, Subhrajyoti Roy, Shubham Bhattacharyya, and Mayukh Hore. "A Comprehensive Review on the Traditional Uses, Phytochemical Compositions and Pharmacological Properties of an Ethnomedicinal Herb, Paederia foetida." Current Traditional Medicine 10 (February 27, 2024). http://dx.doi.org/10.2174/0122150838266756231121075211.

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Background:: Paederia foetida L. (Family – Rubiaceae) is a common herb found available in the temperate and tropical Asia. The ethnomedicinal applications of this plant are widely elaborated In Chinese Traditional Medicine, Ayurveda, and other ancient scriptures throughout the world. Different ethnic groups use this plant in the treatment of alimentary and digestive disorders, bone related diseases like rheumatoid arthritis, bone fractures as well as in the ailments of diabetes, coughs, asthma, itches, wounds, body ache, toothache, cancer etc. Objectives:: This comprehensive review aims to provide an insightful understanding of traditional uses, chemical composition, and pharmacological properties of P. foetida (from 1976 up to 2023), which may provide a foundation for further study and for the proper utilization of P. foetida resources. Methods:: Literature survey was conducted using known databases and the relevant keywords. Results:: P. foetida has been widely used in Chinese traditional medicine (CTM) for the treatment of dyspepsia, jaundice, pains, diarrhea and others. Several ethnic groups throughout the world used this plant to cure common health complaints namely, abdominal pain, gastritis, dysentery, diarrhoea, constipation, joint pain, etc. A total of 24 bioactive phytocompounds, such as asperuloside, paederosidic acid, sitosterols, stigmasterol, campesterol, ellagic acid, iridoids, ursolic acid, epifriedelinol, and others are reported to possess antiulcer, antidiarrheal, antihyperglycemic, antioxidant, antitussive, anthelmintic, and hepatoprotective activities. Conclusion:: The present review not only summarizes the alternative approaches using this herb by ethnic people for treating various disorders, but also focuses on the latest scientific investigations to elucidate different bioactivities of this plant, thereby facilitating the understanding of its correlation with contemporary pharmacology. However, till date, very few studies elucidated the biological properties of these phytochemicals that were isolated exclusively from this particular plant. Moreover, the correlation between phytocompounds from P. foetida and its pharmacological activities aiming towards clinical drug development is still lacking. Finally, further research should be oriented towards determining the optimal dosage and toxicological limits, and thereby providing guidance for clinical applications.

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15

Abdulhafiz, Ferid, Mohd Farhan Hanif Reduan, Anwar Hazim Hisam, et al. "LC–TOF-MS/MS and GC-MS based phytochemical profiling and evaluation of wound healing activity of Oroxylum Indicum (L.) Kurz (Beka)." Frontiers in Pharmacology 13 (November 22, 2022). http://dx.doi.org/10.3389/fphar.2022.1050453.

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Background: Beka (Oroxylum indicum (L.) Kurz) has been used as a culinary herb and natural remedy by the local communities in Malaysia. The leaf of O. indicum is traditionally used for the treatment of diarrhea, high blood pressure, and improving digestive health.Objectives: The present study was conducted to evaluate the phytochemical constituents and wound healing properties (in vitro and in vivo models) of aqueous and ethanol extracts of O. indicum leaves.Methods: The total phenolic (TPC) and total flavonoid (TFC) contents in the plant extracts were determined by the spectrophotometric methods. Further, the extract was characterized by Liquid Chromatography Time-of-Flight Mass Spectrometry (LC-TOF-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS). The wound healing activity was assessed using the in vitro scratch wound-healing assay and in vivo excisional wound model.Results: The results show the ethanol leaves extract had the higher TPC (164 mg GAE/g) when compared with the aqueous leaves extract (30 mg gallic acid equivalents/g). The ethanol leaves extract was also found to have higher TFC (101 mg Catechin equivalents/g) than the aqueous leaves extract (76 mg Catechin equivalents/g). The ethanol leaves extract was then used for further chemical analysis. The LC–TOF-MS/MS analysis showed that the leaves extracts of O. indicum contains many important compounds such as Orientin, Chrysin, Pinoquercetin, Cupressuflavone, Puerarin xyloside, Forsythiaside and Paederoside. In GC-MS analysis, 19 compounds were identified in ethanolic leaves extract. The wound healing studies shows that O. indicum has promising wound healing activity by increasing the rate of wound contraction significantly (p &lt; 0.05).Conclusion: In conclusion, the present study showed that O. indicum leaf contains important phytochemicals and the wound healing potential of the O. indicum extract may probably be as a result of the presence of various phytoconstituents.

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