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Journal articles on the topic 'Paget's Disease, Mammary'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Kanwar, A. J., D. De, K. Vaiphei, A. Bhatia, R. K. Sharma, and G. Singh. "Extensive mammary Paget's disease." Clinical and Experimental Dermatology 32, no. 3 (2007): 326–27. http://dx.doi.org/10.1111/j.1365-2230.2006.02326.x.

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2

del Boz, J., A. Sanz, T. Martín, et al. "Pigmented mammary Paget's disease." Journal of the European Academy of Dermatology and Venereology 21, no. 6 (2007): 844–46. http://dx.doi.org/10.1111/j.1468-3083.2006.02046.x.

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3

Crignis, Giselly Silva Neto de, Luciana de Abreu, Alice Mota Buçard, and Carlos Baptista Barcaui. "Polarized dermoscopy of mammary Paget disease." Anais Brasileiros de Dermatologia 88, no. 2 (2013): 290–92. http://dx.doi.org/10.1590/s0365-05962013000200023.

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Mammary Paget's disease is a rare intraepithelial adenocarcinoma, located on the nipple/areola complex, highly associated with breast cancer. Although the international literature emphasizes the dermatoscopic pattern of mammary Paget's disease pigmented variant, the authors describe the dermoscopic findings of classical Paget's disease and demonstrate the presence of chrysalis-like structures, criteria recently described in the literature and not yet reported in Paget's disease.

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4

Liu, Weiguo, Jabad Iqbal, and Thaer Khoury. "Mammary Paget's disease and extra-mammary Paget's disease: two morphologically similar but biologically different diseases." Journal of Cutaneous Pathology 37, no. 11 (2009): 1145–49. http://dx.doi.org/10.1111/j.1600-0560.2009.01403.x.

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5

Anja, Kerschen, Dano Hélène, Van Eeckhout Pascal, Marot Liliane, and Van Bockstal Mieke. "Not All Cases of Mammary Paget’s Disease are Cytokeratin-7 Positive: A Challenging Diagnosis!" International Journal of Surgical Pathology 29, no. 6 (2021): 631–34. http://dx.doi.org/10.1177/10668969211002920.

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Mammary Paget’s disease accounts for 1% to 3% of all breast tumors and manifests as a chronic eczematous lesion of the areolar skin. It can occur without any underlying neoplasia or can be present in association with an underlying invasive and/or in situ carcinoma of the breast. The present report describes a challenging nipple punch biopsy showing an infiltration of the lower third to two-thirds of the epidermis by large, ovoid, neoplastic cells. The morphology was consistent with mammary Paget's disease, although immunohistochemistry for cytokeratin-7 (CK7) was repeatedly negative. This resu

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6

Abe, S., K. Kabashima, D. Nishio, H. Yasuda, and Y. Tokura. "Quadruple Extra-mammary Paget's disease." Acta Dermato-Venereologica 87, no. 1 (2007): 80–81. http://dx.doi.org/10.2340/00015555-0169.

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7

Lopes Filho, Lauro Lourival, Ione Maria Ribeiro Soares Lopes, Lauro Rodolpho Soares Lopes, Milvia M. S. S. Enokihara, Alexandre Osores Michalany, and Nobuo Matsunaga. "Mammary and extramammary Paget's disease." Anais Brasileiros de Dermatologia 90, no. 2 (2015): 225–31. http://dx.doi.org/10.1590/abd1806-4841.20153189.

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8

Lloyd, J. "Mammary and extramammary Paget's disease." Journal of Clinical Pathology 53, no. 10 (2000): 742–49. http://dx.doi.org/10.1136/jcp.53.10.742.

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9

Martínez Hernández, Andreu, David Martínez Ramos, Miguel Alcalde Sánchez, and José Manuel Laguna Sastre. "Mammary Paget's disease. Conservative mastectomy." Revista de Senología y Patología Mamaria 33, no. 4 (2020): 165–67. http://dx.doi.org/10.1016/j.senol.2020.07.001.

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10

Roš, Tatjana, Marijana Badrkić, Marijana Macanović, Nenad Šolajić, and Branislava Gajić. "Dermoscopy Case of the Month." Serbian Journal of Dermatology and Venereology 9, no. 3 (2017): 135–39. http://dx.doi.org/10.1515/sjdv-2017-0015.

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AbstractMammary Paget's disease is a rare intraepithelial carcinoma of the nipple/areola complex often associated with ductal breast carcinoma. We report a case of a 55-year-old female patient with a classical form of mammary Paget's disease associated ductal ipsilateral breast carcinoma. Dermoscopy of Paget's disease revealed a whitish-pink area with polymorphous vessels organized in irregular nests separated by pale streak-like structures, with peripheral light brown diffuse pigmentation. Dermoscopic features described in this case are in agreement with rare previous reports and may contribu

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11

Watkins, Jean. "A case of mammary Paget's disease." Practice Nursing 25, no. 6 (2014): 290–91. http://dx.doi.org/10.12968/pnur.2014.25.6.290.

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12

Yim, John H., Mark R. Wick, Gordon W. Philpott, Jeffrey A. Norton, and Gerard M. Doherty. "Underlying pathology in mammary Paget's disease." Annals of Surgical Oncology 4, no. 4 (1997): 287–92. http://dx.doi.org/10.1007/bf02303576.

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13

VANSTAPEL, MARIE-JOSÉ, K. C. GATTER, C. DE WOLF-PEETERS, P. R. MILLARD, V. J. DESMET, and D. Y. MASON. "Immunohistochemical study of mammary and extra-mammary Paget's disease." Histopathology 8, no. 6 (2007): 1013–23. http://dx.doi.org/10.1111/j.1365-2559.1984.tb02417.x.

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14

MIZUTANI, Kentaro, Natsuko ISHIDA, Yoichi AKITA, and Daisuke WATANABE. "A case of pigmented mammary Paget's disease of the male." Skin Cancer 27, no. 1 (2012): 98–101. http://dx.doi.org/10.5227/skincancer.27.98.

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15

Laamari, Kaoutar. "Red Plaque of the Breast: Think Of Paget Disease." Journal of Clinical Research and Reports 2, no. 1 (2020): 01. http://dx.doi.org/10.31579/2690-1919/010.

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Paget's disease was first described by Sir Paget in 1874 as an eczema-like lesion of the nipple linked to an underlying cancer. This is a rare entity that affects only 1 to 4% of breast cancers. It mainly affects menopausal women with an average age of 62.6 years. No clinical or epidemiological factors are recognized as predisposing to the development of this disease. Clinically, Paget's mammary disease manifests itself as a scaly, thickened, sometimes pigmented, patchy plaque with irregular edges. This lesion can be limited to the nipple or extended to the areola and even to the surrounding s

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16

JENKINS, I. L., and B. CONROY. "Extra-mammary Paget's Disease of the Penis." British Journal of Urology 63, no. 1 (1989): 103–4. http://dx.doi.org/10.1111/j.1464-410x.1989.tb05139.x.

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17

Shiomi, Tatsuya, Dai Ogata, Mayuko Iwata, Eiichi Arai, and Tetsuya Tsuchida. "Pigmented mammary Paget's disease without underlying carcinoma." Journal of Dermatology 45, no. 11 (2018): e321-e322. http://dx.doi.org/10.1111/1346-8138.14461.

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18

Kim, Ji Eun, Myung Seung Kang, Joung Soo Kim, and Hee Joon Yu. "A Case of Pigmented Mammary Paget's Disease." Annals of Dermatology 20, no. 4 (2008): 240. http://dx.doi.org/10.5021/ad.2008.20.4.240.

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19

Hayes, Robert, Brian Cummings, Robert A. W. Miller, and Ashim K. Guha. "Male Paget's Disease of the Breast." Journal of Cutaneous Medicine and Surgery 4, no. 4 (2000): 208–12. http://dx.doi.org/10.1177/120347540000400408.

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Background: Paget's disease is an extremely rare condition of the male breast that presents as an eczematous change of the nipple and areola. It is almost always associated with an underlying intraductal carcinoma. Objective: A case of Paget's disease of the male breast with extension into adnexal structures is reported. Materials and Methods: A MEDLINE search for cases of Paget's disease of the male breast was performed and the cases were reviewed. The following antibodies were used in immunohistochemical staining: Rabbit Anti-Human c-erbB-2 Oncoprotein, monoclonal Mouse Anti-Human Estrogen R

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20

O'Neill, Danielle, Matthew Evans, David Nunns, and Alaa El-Ghobashy. "Vulval extra-mammary Paget's disease: the master of disguise revealed." British Journal of Hospital Medicine 83, no. 2 (2022): 1–12. http://dx.doi.org/10.12968/hmed.2021.0536.

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Extra-mammary Paget's disease is a rare cancer affecting the anogenital region and can present with a myriad of symptoms. In women, the diagnosis of Paget's disease can be challenging as it mimics several other vulval conditions. It is important to promptly recognise this disease because of its potential association with synchronous tumours, such as colorectal adenocarcinoma. The mainstay of treatment is with immunomodulating therapies or surgery, but unfortunately the risk of recurrence is high and appears to be independent of treatment choice and tissue margin status. There is growing eviden

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21

Meibodi, NaserTayyebi, VahidMashayekhi Ghoyunlu, Zari Javidi, and Yalda Nahidi. "Clinicopathologic evaluation of mammary Paget's disease." Indian Journal of Dermatology 53, no. 1 (2008): 21. http://dx.doi.org/10.4103/0019-5154.39736.

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22

HATTA, Naohito. "Pitfall of guideline for extra-mammary Paget's disease." Skin Cancer 22, no. 3 (2007): 239–44. http://dx.doi.org/10.5227/skincancer.22.239.

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23

Heyderman, E. "The histogenesis of mammary and extramammary Paget's disease." Histopathology 15, no. 5 (1989): 553–54. http://dx.doi.org/10.1111/j.1365-2559.1989.tb01619.x.

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24

JONES, R. RUSSELL, J. SPAULL, and B. GUSTERSON. "The histogenesis of mammary and extramammary Paget's disease." Histopathology 14, no. 4 (1989): 409–16. http://dx.doi.org/10.1111/j.1365-2559.1989.tb02169.x.

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25

Bae, Soo Youn, Ji Eun Lee, Woo-Chan Park, et al. "Clinical subtypes and survival outcomes in invasive breast cancer with Paget’s disease: A SEER population-based study." Journal of Clinical Oncology 41, no. 16_suppl (2023): e12564-e12564. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e12564.

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e12564 Background: The objective of this study was to investigate the clinicopathological characteristics, especially subtypes and survival outcomes of Invasive breast cancer with Paget's disease. Methods: 4930 patients were identified using the histopathology codes from the International Classification of Disease for Oncology third edition (ICD-O-3), from 2000 to 2019 in the Surveillance, Epidemiology, and End Results (SEER) database. Excluding 787 patients whose ICD-O-3 and TNM stages did not match, there were 663 patients with '8540/3, Paget disease, mammary', 976 patients with ‘8543/3, Pag

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26

Jeong, Soo Hyun, Jin Hyeok Hyeong, Eun Joo Park, Kwang Joong Kim, and Kwang Ho Kim. "Human epidermal growth factor receptor 2 expression in extramammary Paget’s disease and mammary Paget's disease." Australasian Journal of Dermatology 63, no. 1 (2021): 115–18. http://dx.doi.org/10.1111/ajd.13782.

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27

Yao, Yufeng, Li Sun, Yan Meng, et al. "Breast-Conserving Surgery in Patients With Mammary Paget's Disease." Journal of Surgical Research 241 (September 2019): 178–87. http://dx.doi.org/10.1016/j.jss.2019.03.025.

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28

Mariani-Costantini, Renato, Salvatore Andreola, and Franco Rilke. "Tumour-associated antigens in mammary and extramammary Paget's disease." Virchows Archiv A Pathological Anatomy and Histopathology 405, no. 3 (1985): 333–40. http://dx.doi.org/10.1007/bf00710069.

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29

Kanitakis, Jean, Jean Thivolet, and Alain Claudy. "p53 protein expression in mammary and extramammary Paget's disease." Journal of Dermatological Science 6, no. 1 (1993): 113. http://dx.doi.org/10.1016/0923-1811(93)91376-6.

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30

Ozerdem, Ugur, Jennifer M. McNiff, and Fattaneh A. Tavassoli. "Cytokeratin 7-negative mammary Paget's disease: A diagnostic pitfall." Pathology - Research and Practice 212, no. 4 (2016): 279–81. http://dx.doi.org/10.1016/j.prp.2016.01.004.

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31

MORI, OSAMU, TADASHI KARASHIMA, KEIZO MATSUO, and TAKASHI HASHIMOTO. "Expression of Desmogleins in Paget Cells of Mammary and Extramammary Paget's Disease." Kurume Medical Journal 44, no. 3 (1997): 185–89. http://dx.doi.org/10.2739/kurumemedj.44.185.

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32

Hida, Tokimasa, Akihiro Yoneta, Takahiro Nishizaka, et al. "Pigmented mammary Paget's disease mimicking melanoma: report of three cases." European Journal of Dermatology 22, no. 1 (2012): 121–24. http://dx.doi.org/10.1684/ejd.2011.1580.

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33

Mori, O., H. Hachisuka, E. Tanikawa, and Y. Sasai. "Expression of ras P21 in mammary and extramammary Paget's disease." Journal of Dermatological Science 1, no. 2 (1990): 124. http://dx.doi.org/10.1016/0923-1811(90)90288-o.

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34

Mori, O., H. Hachisuka, and Y. Sasai. "097 Epidermal cell cultures from mammary and extramammary Paget's disease." Journal of Dermatological Science 12, no. 2 (1996): 198. http://dx.doi.org/10.1016/0923-1811(96)89503-x.

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35

Ordóñez, Nelson G., Hazel Awalt, and Bruce Mackay. "Mammary and extramammary paget's disease. An immunocytochemical and ultrastructural study." Cancer 59, no. 6 (1987): 1173–83. http://dx.doi.org/10.1002/1097-0142(19870315)59:6<1173::aid-cncr2820590624>3.0.co;2-r.

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36

Inokuchi, Kenichiro, and Yoichiro Sasai. "Histochemical analysis of sialomucin in Paget cells of mammary and extramammary Paget's disease." Acta Histochemica 92, no. 2 (1992): 216–23. http://dx.doi.org/10.1016/s0065-1281(11)80083-8.

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37

Gatalica, Zoran, Semir Vranic, Božo Krušlin, et al. "Comparison of the biomarkers for targeted therapies in primary extra‐mammary and mammary Paget's disease." Cancer Medicine 9, no. 4 (2020): 1441–50. http://dx.doi.org/10.1002/cam4.2820.

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38

Citra Kalisa, Raja Eka, Ennesta Asri, and Indah Indria Sari. "Invasive Mammary Paget’s Disease Without Underlying Malignancy: A Case Report." Bioscientia Medicina : Journal of Biomedicine and Translational Research 8, no. 9 (2024): 4937–45. http://dx.doi.org/10.37275/bsm.v8i9.1073.

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Background: Mammary Paget's disease (MPD) with skin invasion is a rare condition that is often associated with an underlying malignancy. However, invasive MPD without malignancy is even rarer and often misdiagnosed. Case presentation: This report presents the case of a 56-year-old woman who presented with a progressively enlarging scaly erythematous plaque on her left nipple for 6 months. Dermoscopy and histopathological examination confirmed the diagnosis of invasive MPD, but radiological examination did not reveal any malignancy. Conclusion: Invasive MPD without malignancy is a rare but impo

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39

ARIYOSHI, Keiko, Toshinori JOUZAKI, Osamu ISHIDOU, Ichiro ITO, and Suguru HANZAWA. "A case report of mammary Paget's disease diagnosed by brush cytology." Journal of the Japanese Society of Clinical Cytology 34, no. 3 (1995): 581–82. http://dx.doi.org/10.5795/jjscc.34.581.

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40

Kuan, Shih-Fan, Anthony G. Montag, John Hart, Thomas Krausz, and Wendy Recant. "Differential Expression of Mucin Genes in Mammary and Extramammary Paget's Disease." American Journal of Surgical Pathology 25, no. 12 (2001): 1469–77. http://dx.doi.org/10.1097/00000478-200112000-00001.

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41

Liegl, Bernadette, Lars-Christian Horn, and Farid Moinfar. "Androgen receptors are frequently expressed in mammary and extramammary Paget's disease." Modern Pathology 18, no. 10 (2005): 1283–88. http://dx.doi.org/10.1038/modpathol.3800437.

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42

ALGUACIL-GARCIA, A., and R. O'CONNOR. "Mucin-negative biopsy in extra-mammary Paget's disease. A diagnostic problem." Histopathology 15, no. 4 (1989): 429–31. http://dx.doi.org/10.1111/j.1365-2559.1989.tb01597.x.

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43

Hida, Tokimasa, and Toshiharu Yamashita. "Pigmented mammary Paget's disease presenting with dermoscopic features of multiple dots." Australasian Journal of Dermatology 55, no. 4 (2013): 260–62. http://dx.doi.org/10.1111/ajd.12086.

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44

Mirer, Ewa, Fouad El Sayed, Alfred Ammoury, Laurence Lamant, Line Messer, and Jacques Bazex. "Treatment of mammary and extramammary Paget's skin disease with topical imiquimod." Journal of Dermatological Treatment 17, no. 3 (2006): 167–71. http://dx.doi.org/10.1080/09546630600788877.

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45

Kiyohara, Takahiro, Atsushi Tokuriki, Yuta Kanamori, Masato Yasuta, Yoshiaki Imamura, and Masanobu Kumakiri. "Superficial sebaceous carcinoma on the areola clinically mimicking mammary Paget's disease." Journal of Dermatology 40, no. 2 (2012): 145–47. http://dx.doi.org/10.1111/1346-8138.12010.

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46

Liegl, B., S. Leibl, M. Gogg-Kamerer, B. Tessaro, L.-C. Horn, and F. Moinfar. "Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases." Histopathology 50, no. 4 (2007): 439–47. http://dx.doi.org/10.1111/j.1365-2559.2007.02633.x.

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47

Mai, Ruiqin, Songxia Zhou, Shuqin Zhou, et al. "Transcriptome analyses reveal FOXA1 dysregulation in mammary and extramammary Paget's disease." Human Pathology 77 (July 2018): 152–58. http://dx.doi.org/10.1016/j.humpath.2017.12.030.

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48

Mantovani, Giulia, Anna Fagotti, Massimo Franchi, Giovanni Scambia, and Giorgia Garganese. "Reviewing vulvar Paget’s disease molecular bases. Looking forward to personalized target therapies: a matter of CHANGE." International Journal of Gynecologic Cancer 29, no. 2 (2019): 422–29. http://dx.doi.org/10.1136/ijgc-2018-000080.

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ObjectivesTo review the published literature on vulvar Paget’s disease (VPD) molecular bases, aiming to support the need for tailored treatment in women affected by this 'orphan' tumor.MethodsMEDLINE-PubMed and Scopus were interrogated using the following algorithm: (extramammary OR extra mammary OR vulvar) AND (paget OR pagets OR paget's) AND (molecular OR biological OR marker OR protein OR target OR expression). The inclusion criteria for papers were: peer-reviewed English-language journals, articles published in the last 30 years, studies focused on fixed research questions, quality assessm

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49

Ohira, S., K. Itoh, K. Osada, et al. "Vulvar Paget's disease with underlying adenocarcinoma simulating breast carcinoma: case report and review of the literature." International Journal of Gynecologic Cancer 14, no. 5 (2004): 1012–17. http://dx.doi.org/10.1136/ijgc-00009577-200409000-00040.

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We report a case of extramammary Paget's disease with underlying adenocarcinoma simulating breast carcinoma of the vulva. An 82-year-old woman was found to have a 5 × 3-cm bulky tumor located in the left labium major, infiltrating to the clitoris, left labium minor, and left lateral tissue of the vulva. Small biopsy of the vulva showed intraepidermal proliferation of Paget cells. The patient underwent wide local excision of the vulvar tumor and dissection of left inguinal lymph nodes. Histopathological examination of the resected specimens revealed that Paget cells were distributed singly or t

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50

Kondo, Yoshiyuki, Kenji Kashima, Tsutomu Daa, Sakuhei Fujiwara, Iwao Nakayama, and Shigeo Yokoyama. "The Ectopic Expression of Gastric Mucin in Extramammary and Mammary Paget's Disease." American Journal of Surgical Pathology 26, no. 5 (2002): 617–23. http://dx.doi.org/10.1097/00000478-200205000-00007.

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