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Journal articles on the topic 'Pain Pain Prostaglandins Nitric Oxide'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Minami, Toshiaki, Masato Sakai, Naoki Hara, Masahiko Onaka, Hidemaro Mori, and Seiji Ito. "Nitric Oxide Mediates Hyperalgesia Induced by Intrathecal Administration of Prostaglandin E2 in Conscious Mice." PAIN RESEARCH 11, no. 2 (1996): 63–70. http://dx.doi.org/10.11154/pain.11.63.

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Toda, Noboru, Hiroshi Toda, Yoshio Hatano, and David C. Warltier. "Nitric Oxide." Anesthesiology 107, no. 5 (2007): 822–42. http://dx.doi.org/10.1097/01.anes.0000287213.98020.b6.

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There has been an explosive increase in the amount of interesting information about the physiologic and pathophysiologic roles of nitric oxide in cardiovascular, nervous, and immune systems. The possible involvement of the nitric oxide-cyclic guanosine monophosphate pathway in the effects of anesthetic agents has been the focus of many investigators. Relaxations of cerebral and peripheral arterial smooth muscle as well as increases in cerebral and other regional blood flows induced by anesthetic agents are mediated mainly via nitric oxide released from the endothelium and/or the nitrergic nerv

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de Larminat, V., J. Boczkowski, B. Dureuil, M. Aubier, and J. M. Desmonts. "Role of prostaglandins and nitric oxide (NO) in arteriolar haiothane-induced vasodilation." Anesthesiology 77, Supplement (1992): A683. http://dx.doi.org/10.1097/00000542-199209001-00683.

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Chen, Xiaojie, and Jon D. Levine. "NOS Inhibitor Antagonism of PGE2-Induced Mechanical Sensitization of Cutaneous C-Fiber Nociceptors in the Rat." Journal of Neurophysiology 81, no. 3 (1999): 963–66. http://dx.doi.org/10.1152/jn.1999.81.3.963.

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NOS inhibitor antagonism of PGE2-induced mechanical sensitization of cutaneous C-fiber nociceptors in the rat. Prostaglandins, metabolites of arachidonic acid, released during tissue injury and inflammation sensitize primary afferent nociceptors. While it has been suggested that this effect on nociceptors is mediated mainly via the cAMP second messenger system, recent evidence suggests that nitric oxide (NO) is also involved in peripheral pain mechanisms. To test the hypothesis that NO contributes to the sensitization of nociceptors to mechanical stimuli induced by hyperalgesic prostaglandins,

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Honoré, Per Hartvig, Anna Basnet, Pernille Kristensen, et al. "Predictive validity of pharmacologic interventions in animal models of neuropathic pain." Scandinavian Journal of Pain 2, no. 4 (2011): 178–84. http://dx.doi.org/10.1016/j.sjpain.2011.06.002.

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AbstractIntroductionThe pathophysiologic and neurochemical characteristics of neuropathic pain must be considered in the search for new treatment targets. Breakthroughs in the understanding of the structural and biochemical changes in neuropathy have opened up possibilities to explore new treatment paradigms. However, long term sequels from the damage are still difficult to treat.Aim of the studyTo examine the validity of pharmacological treatments in humans and animals for neuropathic pain.MethodAn overview from the literature and own experiences of pharmacological treatments employed to inte

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Hefferan, Michael P., and Christopher W. Loomis. "Interaction of Spinal Nitric Oxide and Prostaglandins after L5–L6 Spinal Nerve Ligation in the Rat." Anesthesiology 100, no. 6 (2004): 1611–14. http://dx.doi.org/10.1097/00000542-200406000-00040.

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Nakahata, Katsutoshi, Hiroyuki Kinoshita, Keiko Hama-Tomioka, et al. "Cholinesterase Inhibitor Donepezil Dilates Cerebral Parenchymal Arterioles via the Activation of Neuronal Nitric Oxide Synthase." Anesthesiology 109, no. 1 (2008): 124–29. http://dx.doi.org/10.1097/aln.0b013e31817c0316.

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Background An acetylcholinesterase inhibitor donepezil currently is used to treat patients with Alzheimer disease. However, its direct effect on cerebral blood vessels has not been evaluated. The present study was designed to examine whether donepezil induces acute cerebral arteriolar dilation and whether neuronal nitric oxide synthase contributes to this vasodilator response. Methods Brain slices were obtained from neuronal nitric oxide synthase knock-out or C57BL/6J strain (control) mice as well as Wistar rats. Parenchymal arterioles were monitored using videomicroscopy. During constriction

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Toriyabe, Masaki, Keiichi Omote, Tomoyuki Kawamata, and Akiyoshi Namiki. "Contribution of Interaction between Nitric Oxide and Cyclooxygenases to the Production of Prostaglandins in Carrageenan-induced Inflammation." Anesthesiology 101, no. 4 (2004): 983–90. http://dx.doi.org/10.1097/00000542-200410000-00025.

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Background Nitric oxide (NO) and prostaglandins (PGs) are crucial mediators contributing to generation of inflammatory responses and pain. This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation. Methods A microdialysis probe was implanted subcutaneously into the skin of hind paws of rats. The concentrations of NO metabolites, PGE2, and 6-keto-PGF1alpha (metabolite of PGI2) in the dialysate were measured. Carrageenan was injected into the plantar surface of the hind pa

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Singh, Sumitra, and Bhagwati Devi. "ETHANOMEDICINAL PLANTS WITH ANTI-INFLAMMATORY EFFECT FROM SOUTHERN HARYANA, INDIA: A REVIEW." International Journal of Advanced Research 8, no. 12 (2020): 1013–34. http://dx.doi.org/10.21474/ijar01/12248.

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Inflammation is a physiological host response to external challenges or cellular injury such as pathogens, damaged cells or irritants leading to the release of a complex array of inflammatory mediators and aiding the recovery of tissue structure and function.All inflammatory processes develop along a known sequence: locally increased blood supply, leakage of fluid, small molecule or proteins and infiltration of cells.Inflammation is not a synonym for infection, even in case where inflammation is caused by infection, response includes clinical signs of erythema, edema, hyperalgesia and pain. Si

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Kehl, Franz, Hui Shen, Carol Moreno, et al. "Isoflurane-induced Cerebral Hyperemia Is Partially Mediated by Nitric Oxide and Epoxyeicosatrienoic Acids in Mice In Vivo." Anesthesiology 97, no. 6 (2002): 1528–33. http://dx.doi.org/10.1097/00000542-200212000-00027.

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Background Despite intense investigation, the mechanism of isoflurane-induced cerebral hyperemia is unclear. The current study was designed to determine the contributions of neuronal nitric oxide synthase, prostaglandins, and epoxyeicosatrienoic acids to isoflurane-induced cerebral hyperemia. Methods Regional cerebral cortical blood flow was measured with laser Doppler flowmetry during stepwise increases of isoflurane from 0.0 to 1.2, 1.8, and 2.4 vol% end-tidal concentration in alpha-chloralose-urethane-anesthetized, C57BL/6 mice before and 45 min after administration of the neuronal nitric o

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Pethő, Gábor, and Peter W. Reeh. "Sensory and Signaling Mechanisms of Bradykinin, Eicosanoids, Platelet-Activating Factor, and Nitric Oxide in Peripheral Nociceptors." Physiological Reviews 92, no. 4 (2012): 1699–775. http://dx.doi.org/10.1152/physrev.00048.2010.

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Peripheral mediators can contribute to the development and maintenance of inflammatory and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two mechanisms. Activation or excitation by these substances of nociceptive nerve endings or fibers implicates generation of action potentials which then travel to the central nervous system and may induce pain sensation. Sensitization of nociceptors refers to their increased responsiveness to either thermal, mechanical, or chemical stimuli that may be translated to corresponding hyperalgesias. This review aims to give an account of t

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O’Rielly, Darren D., and Christopher W. Loomis. "Increased Expression of Cyclooxygenase and Nitric Oxide Isoforms, and Exaggerated Sensitivity to Prostaglandin E2, in the Rat Lumbar Spinal Cord 3 Days after L5–L6 Spinal Nerve Ligation." Anesthesiology 104, no. 2 (2006): 328–37. http://dx.doi.org/10.1097/00000542-200602000-00019.

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Background Spinal prostaglandins seem to be important in the early pathogenesis of experimental neuropathic pain. Here, the authors investigated changes in the expression of cyclooxygenase and nitric oxide synthase (NOS) isoforms in the lumbar, thoracic, and cervical spinal cord and the pharmacologic sensitivity to spinal prostaglandin E2 (PGE2) after L5-L6 spinal nerve ligation (SNL). Methods Male Sprague-Dawley rats, fitted with intrathecal catheters, underwent SNL or sham surgery 3 days before experimentation. Paw withdrawal threshold was monitored for up to 20 days. Immunoblotting, spinal

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Ilari, Sara, Concetta Dagostino, Valentina Malafoglia, et al. "Protective Effect of Antioxidants in Nitric Oxide/COX-2 Interaction during Inflammatory Pain: The Role of Nitration." Antioxidants 9, no. 12 (2020): 1284. http://dx.doi.org/10.3390/antiox9121284.

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In clinical practice, inflammatory pain is an important, unresolved health problem, despite the utilization of non-steroidal anti-inflammatory drugs (NSAIDs). In the last decade, different studies have proven that reactive oxygen species (ROS) and reactive nitrogen species (RNS) are involved in the development and maintenance of inflammatory pain and hyperalgesia via the post-translation modification of key proteins, such as manganese superoxide dismutase (MnSOD). It is well-known that inducible cyclooxygenase 2 (COX-2) plays a crucial role at the beginning of the inflammatory response by conv

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Staunton, Michael, Cathy Drexler, Phillip G. Schmid, Heather S. Havlik, Antal G. Hudetz, and Neil E. Farber. "Neuronal Nitric Oxide Synthase Mediates Halothane-induced Cerebral Microvascular Dilation." Anesthesiology 92, no. 1 (2000): 125. http://dx.doi.org/10.1097/00000542-200001000-00023.

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Background The causes of volatile anesthetic-induced cerebral vasodilation include direct effects on smooth muscle and indirect effects via changes in metabolic rate and release of mediators from vascular endothelium and brain parenchyma. The role of nitric oxide and the relative importance of neuronal and endothelial nitric oxide synthase (nNOS and eNOS, respectively) are unclear. Methods Rat brain slices were superfused with oxygenated artificial cerebrospinal fluid. Hippocampal arteriolar diameters were measured using computerized videomicrometry. Vessels were preconstricted with prostaglan

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Kavanagh, Brian P., John S. Thompson, and Ronald G. Pearl. "Inhibition of Endogenous Nitric Oxide Synthase Potentiates Nitrovasodilators in Experimental Pulmonary Hypertension." Anesthesiology 85, no. 4 (1996): 860–66. http://dx.doi.org/10.1097/00000542-199610000-00022.

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Background The role of endogenous nitric oxide (NO) in the regulation of pulmonary vascular tone is complex. Inhibition of endogenous NO synthase, potentially through upregulation of guanylyl cyclase, results in an increase in potency of nitrovasodilators in the systemic circulation. This study considered whether inhibition of endogenous NO synthase would increase the potency of nitrovasodilators, but not of cyclic adenosine monophosphate-dependent vasodilators, in the pulmonary vasculature. Methods We used the isolated buffer-perfused rabbit lung. Preparations were randomized to receive eithe

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Rajek, Angela, Thomas Pernerstorfer, Johannes Kastner, et al. "Inhaled Nitric Oxide Reduces Pulmonary Vascular Resistance More Than Prostaglandin E1 During Heart Transplantation." Anesthesia & Analgesia 90, no. 3 (2000): 523–30. http://dx.doi.org/10.1097/00000539-200003000-00005.

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Chandrakanthan, Madhuvanthi, Shiroma M. Handunnetti, Galbada Sirimal Arachchige Premakumara, and Selvaluxmy Kathirgamanathar. "Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action." Evidence-Based Complementary and Alternative Medicine 2020 (April 28, 2020): 1–19. http://dx.doi.org/10.1155/2020/2035671.

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This study aimed at investigating the anti-inflammatory potential of essential oil from rhizome and leaf of Alpinia calcarata Rosc. (ACEO) with the focus of its topical anti-inflammatory activity along with its dominant compounds 1,8-cineole and α-terpineol using mouse ear edema model. ACEOs were analyzed by GC-MS. The anti-inflammatory activity was determined by studying the inhibition of overproduction of proinflammatory mediators—nitric oxide, reactive oxygen species, prostaglandins, cyclooxygenases, and cytokines induced by lipopolysaccharides in murine macrophages. Topical anti-inflammato

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Augoustides, John G., and E. Andrew Ochroch. "Pro: Inhaled Prostaglandin as a Pulmonary Vasodilator Instead of Nitric Oxide." Journal of Cardiothoracic and Vascular Anesthesia 19, no. 3 (2005): 400–402. http://dx.doi.org/10.1053/j.jvca.2005.03.036.

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Dickstein, Marc L. "Con: Inhaled Prostaglandin as a Pulmonary Vasodilator instead of Nitric Oxide." Journal of Cardiothoracic and Vascular Anesthesia 19, no. 3 (2005): 403–5. http://dx.doi.org/10.1053/j.jvca.2005.03.037.

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Eka Widyadharma, I. Putu, Agung Bagus Sista Satyarsa, Feliani Sanjaya, et al. "POTENTIAL OF ANTHOCYANIN BASED POLY (METHYL METHACRYLATE) NANOPARTICLES SPECIFIC ACTIVATED MICROGLIA IN MANAGEMENT INFLAMMATORY PAIN ON HERNIATED NUCLEUS PULPOSUS: A LITERATURE REVIEW." MNJ (Malang Neurology Journal) 7, no. 1 (2021): 40–47. http://dx.doi.org/10.21776/ub.mnj.2021.007.01.9.

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Pain is an unpleasant sensory and emotional experience that can affect the quality of life and leads to decreased productivity in patients. Low back pain (LBP) is one of the significant causes of disability worldwide with lifelong incidence. The purpose of this literature review describes the potential of anthocyanin-based Poly (Methyl Methacrylate) (PMMA) nanoparticles as the management of inflammatory pain in the Hernia Nucleus Pulposus (HNP ). The method used is a literature study by entering the keyword. Of the 77 journals reviewed, 47 journals were found by the topic and used as a referen

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Cairns, Brian E., Jens C. Laursen, Xu-Dong Dong, and Parisa Gazerani. "Intraganglionic injection of a nitric oxide donator induces afferent mechanical sensitization that is attenuated by palmitoylethanolamide." Cephalalgia 34, no. 9 (2014): 686–94. http://dx.doi.org/10.1177/0333102414521510.

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Aim The aim of this article is to investigate whether the nitric oxide (NO) donator diethylenetriamine/nitric oxide (DETA/NO) affects trigeminal sensory processing through the trigeminal ganglion in part by activating trigeminal satellite glial cells (SGCs) and whether this effect is attenuated by the anti-inflammatory compound palmitoylethanolamide (PEA). Methods DETA/NO was administered to isolated rat trigeminal SGCs in vitro, and injected into the rat trigeminal ganglion in vivo, in the presence or absence of PEA. Results Administration of DETA/NO (1000 µM) increased the release of prostag

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Shen, Hui, Anthony G. Hudetz, Neil E. Farber, Richard J. Roman, and John P. Kampine. "Room D, 10/17/2000 9: 00 AM - 11: 00 AM (PS) Contribution of Nitric Oxide, Prostaglandins and Epoxyeicosatrienoic Acids to Isoflurane-Induced Cerebral Hyperemia in Mice." Anesthesiology 93, no. 3A (2000): A—769. http://dx.doi.org/10.1097/00000542-200009001-00769.

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Siracusa, Rosalba, Francesco Monaco, Ramona D’Amico, et al. "Epigallocatechin-3-Gallate Modulates Postoperative Pain by Regulating Biochemical and Molecular Pathways." International Journal of Molecular Sciences 22, no. 13 (2021): 6879. http://dx.doi.org/10.3390/ijms22136879.

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Treating postoperative (PO) pain is a clinical challenge. Inadequate PO pain management can lead to worse outcomes, for example chronic post-surgical pain. Therefore, acquiring new information on the PO pain mechanism would increase the therapeutic options available. In this paper, we evaluated the role of a natural substance, epigallocatechin-3-gallate (EGCG), on pain and neuroinflammation induced by a surgical procedure in an animal model of PO pain. We performed an incision of the hind paw and EGCG was administered for five days. Mechanical allodynia, thermal hyperalgesia, and motor dysfunc

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Adrie, Christophe, Mona W. Hirani, Alexandra Holzmann, Larry Keefer, Warren M. Zapol, and William E. Hurford. "Selective Pulmonary Vasodilation by Intravenous Infusion of an Ultrashort Half-life Nucleophile/Nitric Oxide Adduct." Anesthesiology 88, no. 1 (1998): 190–95. http://dx.doi.org/10.1097/00000542-199801000-00027.

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Background PROLI/NO (C5H7N3O4Na2 x CH3OH) is an ultrashort-acting nucleophile/NO adduct that generates NO (half-life 2 s at 37 degrees C and pH 7.4). Because of its short half-life, the authors hypothesized that intravenous administration of this compound would selectively dilate the pulmonary vasculature but cause little or no systemic hypotension. Methods In eight awake healthy sheep with pulmonary hypertension induced by 9,11-dideoxy-9alpha,11alpha-methanoepoxy prostaglandin F2alpha, the authors compared PROLI/NO with two reference drugs-inhaled NO, a well-studied selective pulmonary vasodi

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Staunton, Michael, Cathy Drexler, Michael G. Dulitz, Dale C. Ekbom, William T. Schmeling, and Neil E. Farber. "Effects of Hypoxia–Reoxygenation on Microvascular Endothelial Function in the Rat Hippocampal Slice." Anesthesiology 91, no. 5 (1999): 1462. http://dx.doi.org/10.1097/00000542-199911000-00040.

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Background Cerebral ischemia and hypoxia may cause injury to both neuronal and vascular tissue. The direct effects of hypoxia on endothelial function in intraparenchymal cerebral arterioles are unknown. Using a modification of the rat brain slice preparation, allowing continuous imaging of these previously inaccessible vessels, microvessel dilation was evaluated before and after a brief hypoxic episode. Methods Rat brain slices were superfused with oxygenated artificial cerebrospinal fluid. Hippocampal arterioles were visualized using computerized videomicroscopy, and their diameters (range, 1

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Minami, Toshiaki, Isao Nishihara, Seiji Ito, Kazuichi Sakamoto, Masayoshi Hyodo та Osamu Hayaishi. "Nitric oxide mediates allodynia induced by intrathecal administration of prostaglandin E2 or prostaglandin F2α in conscious mice". Pain 61, № 2 (1995): 285–90. http://dx.doi.org/10.1016/0304-3959(94)00183-f.

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Milne, Brian, Sean R. Hall, Michael E. Sullivan, and Chris Loomis. "The Release of Spinal Prostaglandin E2 and the Effect of Nitric Oxide Synthetase Inhibition During Strychnine-Induced Allodynia." Anesthesia & Analgesia 93, no. 3 (2001): 728–33. http://dx.doi.org/10.1097/00000539-200109000-00037.

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Wang, Tian-Xing, Guo-Jie Wu, and Jian-Guo Jiang. "Natural Products with Analgesic Effect from Herbs and Nutraceuticals Used in Traditional Chinese Medicines." Current Molecular Medicine 20, no. 6 (2020): 461–83. http://dx.doi.org/10.2174/1566524019666191205111937.

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Introduction: Pain is one of the most common clinical symptoms . This review aims to describe research on herbs and their active ingredients in treating pain and provide a valuable reference for the development and utilization of analgesic traditional Chinese medicine (TCM). Materials and Methods: The literature search was performed from 1995 to October 2016, covering the relevant studies that concern the treatment of pain with TCM. Active ingredients extracted from TCM with analgesic activity are summarized and classified into six categories, including polysaccharides, saponins, alkaloids, fl

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Triantafillou, A. N., Mary S. Pohl, K. Okayabashi, J. D. Cooper, G. A. Patterson, and D. G. Lappas. "EFFECTS OF INHALED NITRIC OXIDE AND PROSTAGLANDIN E1 ON HEMODYNAMICS AND ARTERIAL OXYGENATION IN PATIENTS FOLLOWING SINGLE LUNG TRANSPLANTATION." Anesthesia & Analgesia 80, Supplement (1995): SCA40. http://dx.doi.org/10.1213/00000539-199504001-00039.

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Rajek, M. A., M. Hiesmayr, D. Heilinger, P. Mares, J. Kastner, and W. Haider. "CONTROLLED TRIAL ON PREVENTION OF ACUTE RIGHT HEART FAILURE AFTER HEART TRANSPLANTATION WITH NITRIC OXIDE INHALATION OR PROSTAGLANDIN INFUSION." Anesthesia & Analgesia 80, Supplement (1995): SCA101. http://dx.doi.org/10.1213/00000539-199504001-00100.

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Rodriguez, Stephanie, Mariano Walter Pertino, Chantal Arcos, et al. "Isolation, Gastroprotective Effects and Untargeted Metabolomics Analysis of Lycium Minutifolium J. Remy (Solanaceae)." Foods 9, no. 5 (2020): 565. http://dx.doi.org/10.3390/foods9050565.

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Lycium minutifolium J. Remy (Solanaceae) is commonly used as an infusion in traditional medicine to treat stomach pain, meteorism, intestinal disorders, stomach ailments, and other severe problems including prostate cancer and stomach cancer. From the EtOAc extract of L. minutifolium bark five known metabolites were isolated using chromatographic techniques. The gastroprotective effects of the EtOAc fraction and edible infusion extract of the bark were assayed on the hydrochloric acid (HCl)/EtOH induced gastric ulcer model in mice to support the traditional use of the plant. The EtOAc extract

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Sobeh, Mahmoud, Rezq та ін. "Salix tetrasperma Roxb. Extract Alleviates Neuropathic Pain in Rats via Modulation of the NF-κB/TNF-α/NOX/iNOS Pathway". Antioxidants 8, № 10 (2019): 482. http://dx.doi.org/10.3390/antiox8100482.

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Patients with neuropathic pain experience chronic painful tingling, burning, and prickling sensations accompanied with hyperalgesia and/or allodynia. In this study, 38 secondary metabolites of a methanol extract from Salix tetrasperma flowers were identified by liquid chromatography-mass spectrometry (HPLC-MS/MS). The extract showed substantial anti-inflammatory, central and peripheral anti-nociceptive, antipyretic, and antioxidant activities in vitro and in different animal models. In the chronic constriction injury (CCI) rat model, the extract was able to attenuate and significantly relieve

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Park, So Hyun, Ji-Young Hong, Won Kyung Kim, et al. "Effects of SHINBARO2 on Rat Models of Lumbar Spinal Stenosis." Mediators of Inflammation 2019 (April 28, 2019): 1–11. http://dx.doi.org/10.1155/2019/7651470.

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Lumbar spinal stenosis (LSS) is a major cause of chronic low back pain; however, only a few therapies which have been used in clinics still have limited effects on functional recovery. SHINBARO2 is a refined traditional formulation for inflamed lesions and relieve pain of muscular skeletal disease. This study aimed at investigating the effects of SHINBARO2 on LSS and at determining its underlying molecular mechanism in rat models. The LSS rat models were set up by surgical operations in 6-week-old male Sprague-Dawley rats. SHINBARO2 was orally or intraperitoneally administered for 14 days. The

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Matsui, Tomohiro, Camilla I. Svensson, Yuka Hirata, Kanae Mizobata, Xiao-Ying Hua, and Tony L. Yaksh. "Release of Prostaglandin E2 and Nitric Oxide from Spinal Microglia Is Dependent on Activation of p38 Mitogen-Activated Protein Kinase." Anesthesia & Analgesia 111, no. 2 (2010): 554–60. http://dx.doi.org/10.1213/ane.0b013e3181e3a2a2.

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Lopes, Juliana Agostinho, Vinícius Peixoto Rodrigues, Marcelo Marucci Pereira Tangerina, et al. "Machaerium hirtum (Vell.) Stellfeld Alleviates Acute Pain and Inflammation: Potential Mechanisms of Action." Biomolecules 10, no. 4 (2020): 590. http://dx.doi.org/10.3390/biom10040590.

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Machaerium hirtum (Vell.) Stellfeld (Fabaceae) known in Brazil as “jacaranda de espinho” or “espinheira santa nativa” is a medicinal plant commonly used in folk medicine to treat ulcers, cough and diarrhea. This study aimed to investigate the anti-inflammatory and antinociceptive effects of hydroalcoholic extracts from M. hirtum twig (HEMh) using in vivo experimental models of nociception through the involvement of transient receptor potential channels, acid-sensing ion channel (ASIC), nitrergic, opioidergic, glutamatergic, and supraspinal pathways. Our results revealed an antinociceptive effe

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Dolan, Sharron, Lois C. Field, and Andrea M. Nolan. "The role of nitric oxide and prostaglandin signaling pathways in spinal nociceptive processing in chronic inflammation." Pain 86, no. 3 (2000): 311–20. http://dx.doi.org/10.1016/s0304-3959(00)00262-1.

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Ferrini, Francesco, and Yves De Koninck. "Microglia Control Neuronal Network Excitability via BDNF Signalling." Neural Plasticity 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/429815.

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Microglia-neuron interactions play a crucial role in several neurological disorders characterized by altered neural network excitability, such as epilepsy and neuropathic pain. While a series of potential messengers have been postulated as substrates of the communication between microglia and neurons, including cytokines, purines, prostaglandins, and nitric oxide, the specific links between messengers, microglia, neuronal networks, and diseases have remained elusive. Brain-derived neurotrophic factor (BDNF) released by microglia emerges as an exception in this riddle. Here, we review the curre

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Lee, Yun Mi, and Dong-Seon Kim. "The Extraction Solvent Influences the Anti-Inflammatory Effects of Jakyakgamcho-Tang in Lipopolysaccharide-Stimulated Macrophages and Mice with Gouty Arthritis." International Journal of Molecular Sciences 21, no. 24 (2020): 9748. http://dx.doi.org/10.3390/ijms21249748.

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Jakyakgamcho-Tang (JGT) is a traditional medicine used to treat muscular tension, spasm, and pain. Several studies have reported its clinical use as an anti-inflammatory and in gynaecological treatment. This study aimed to compare the anti-inflammatory effects of JGT according to extraction solvent, water (JGTW) and 30% EtOH (JGTE) on lipopolysaccharide (LPS)—stimulated macrophages and in mice with monosodium urate (MSU)—induced gouty arthritis. We evaluated the production of inflammatory mediators and cytokines and the expression of inducible nitric oxide (iNOS) and cyclooxygenase-2 (COX-2) i

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Hsu, Ming-Man, Yen-Yen Chou, Yi-Chen Chang, Tz-Chong Chou, and Chih-Shung Wong. "An Analysis of Excitatory Amino Acids, Nitric Oxide, and Prostaglandin E2 in the Cerebrospinal Fluid of Pregnant Women: The Effect on Labor Pain." Anesthesia & Analgesia 93, no. 5 (2001): 1293–96. http://dx.doi.org/10.1097/00000539-200111000-00053.

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González-Correa, José Antonio, María Monsalud Arrebola, Eva Martín-Salido, Javier Muñoz-Marín, Felipe Sánchez de la Cuesta, and José Pedro De La Cruz. "Effects of Dexibuprofen on Platelet Function in Humans." Anesthesiology 106, no. 2 (2007): 218–25. http://dx.doi.org/10.1097/00000542-200702000-00008.

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Background The aim of the current study is to evaluate the antiplatelet effect of dexibuprofen in healthy volunteers in comparison with low-dose aspirin. Methods Healthy volunteers (n = 12) were treated in a crossover manner with 100 mg daily aspirin or with 800 mg daily dexibuprofen. Blood samples were obtained within 24 h; 3, 7, and 14 days after repeated doses; and 24 h after the last dose. In each sample, the authors measured platelet aggregation, thromboxane B2, 6-keto-prostaglandin F1alpha, and nitric oxide. Results The antiplatelet effect of dexibuprofen (maximal inhibition of aggregati

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Yun, Chanyong, Youngchul Jung, Wonjoo Chun, et al. "Anti-Inflammatory Effects ofArtemisiaLeaf Extract in Mice with Contact DermatitisIn VitroandIn Vivo." Mediators of Inflammation 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/8027537.

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The leaves ofArtemisia argyiLev. et Vant. andA. princepsPamp. are well known medicinal herbs used to treat patients in China, Japan, and Korea with skin problems such as eczema and itching, as well as abdominal pain and dysmenorrhoea. We investigated the anti-inflammatory effects ofArtemisialeaf extract (ALE) using CD mice and Raw 264.7 cells. The effects of ALE on histopathological changes and cytokine production in ear tissues were assessed in mice with CD induced by 1-fluoro-2,4-dinitrobenzene (DNFB). Moreover, the anti-inflammatory effects on production levels of prostaglandin E2(PGE2) and

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Kang, Jin-Kyu, You-Chul Chung та Chang-Gu Hyun. "Anti-Inflammatory Effects of 6-Methylcoumarin in LPS-Stimulated RAW 264.7 Macrophages via Regulation of MAPK and NF-κB Signaling Pathways". Molecules 26, № 17 (2021): 5351. http://dx.doi.org/10.3390/molecules26175351.

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Persistent inflammatory reactions promote mucosal damage and cause dysfunction, such as pain, swelling, seizures, and fever. Therefore, in this study, in order to explore the anti-inflammatory effect of 6-methylcoumarin (6-MC) and suggest its availability, macrophages were stimulated with lipopolysaccharide (LPS) to conduct an in vitro experiment. The effects of 6-MC on the production and levels of pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α) and inflammatory mediators (nitric oxide (NO), prostaglandin E2 (PGE2)) in LPS-stimulated RAW 264.7 cells were e

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Stowe, D. F., J. S. Heisner, W. W. Chung, and S. Fujita. "Volatile anaesthetics restore bradykinin and serotonin-induced coronary vasodilation after blocking nitric oxide synthase: lack of anaesthetic effects on KATP channels and prostaglandin pathways." European Journal of Anaesthesiology 18, no. 4 (2001): 219–30. http://dx.doi.org/10.1097/00003643-200104000-00003.

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Stowe, D. F., J. S. Heisner, W. W. Chung, and S. Fujita. "Volatile anaesthetics restore bradykinin and serotonin-induced coronary vasodilation after blocking nitric oxide synthase: lack of anaesthetic effects on KATP channels and prostaglandin pathways." European Journal of Anaesthesiology 18, no. 4 (2001): 219–30. http://dx.doi.org/10.1046/j.0265-0215.2000.00853.x.

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Baek, Sang Bin, Mal Soon Shin, Jin Hee Han, et al. "Rocuronium Bromide Inhibits Inflammation and Pain by Suppressing Nitric Oxide Production and Enhancing Prostaglandin E₂ Synthesis in Endothelial Cells." International Neurourology Journal 20, no. 4 (2016): 296–303. http://dx.doi.org/10.5213/inj.1632796.398.

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Kieler-Jensen, N., S. Lundin, and S. E. Ricksten. "Vasodilator therapy after heart transplantation. Effects of inhaled nitric oxide and intravenous prostacyclin, prostaglandin E1 and sodium nitroprusside." Journal of Cardiothoracic and Vascular Anesthesia 8, no. 5 (1994): 2. http://dx.doi.org/10.1016/1053-0770(94)90311-5.

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Huang, Shan, Hai Feng Liu, Xianghua Quan, et al. "Rhamnella gilgitica Attenuates Inflammatory Responses in LPS-Induced Murine Macrophages and Complete Freund’s Adjuvant-Induced Arthritis Rats." American Journal of Chinese Medicine 44, no. 07 (2016): 1379–92. http://dx.doi.org/10.1142/s0192415x16500774.

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Rhamnella gilgitica Mansf. et Melch, which belongs to the rhamnus family (Rhamnaceae), is traditionally used to treat rheumatism, swelling and pain in China. However, little is known about the pharmacological activities of this plant. The anti-inflammatory activities of the 70% ethanol extract of R. gilgitica (RG) in RAW264.7 macrophages and complete Freund’s adjuvant (CFA)-induced arthritic rats are investigated in this study for the first time. The effects of RG on cell viability were determined by a MTT assay, and the effects of RG on pro-inflammatory mediators were analyzed by ELISA and We

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Ohara, Maria, Teiji Sawa, Kiyoyasu Kurahashi, et al. "Induction of Cyclooxygenase-2 in Alveolar Macrophages after Acid Aspiration." Anesthesiology 88, no. 4 (1998): 1014–22. http://dx.doi.org/10.1097/00000542-199804000-00022.

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Background Gastric acid aspiration can result in acute lung injury. In this study, the authors determined whether alveolar macrophages express cyclooxygenase-2 as a source of inflammatory mediators after acid aspiration. Methods Seventy-five microliters of hydrochloric acid solution, pH 1.15, was instilled into one lung in mice. After exposure, alveolar macrophages were harvested, and competitive polymerase chain reaction and enzyme-linked immunosorbent assay were performed to measure expression of cyclooxygenase-1 and -2, interleukin-1beta and -6, tumor necrosis factor-alpha, and inducible ni

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Vetter, Gregor, Gerd Geisslinger, and Irmgard Tegeder. "Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation." Pain 92, no. 1 (2001): 213–18. http://dx.doi.org/10.1016/s0304-3959(01)00258-5.

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Schankin, CJ, M. Krumbholz, P. Sostak, VM Reinisch, R. Goldbrunner, and A. Straube. "Headache in patients with a meningioma correlates with a bone-invasive growth pattern but not with cytokine expression." Cephalalgia 30, no. 4 (2009): 413–24. http://dx.doi.org/10.1111/j.1468-2982.2009.01945.x.

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We included 58 patients with meningioma in a prospective study to analyse the prevalence of and risk factors for different types of meningioma-associated headache. Twenty-three patients (40%) had meningioma-associated headache. Of these, the pain was migraine-like in five (22%) and tension-type headache (TTH)-like in 13 (57%). Sixteen of 21 (76%) experienced relief of pain intensity of at least 50% after 18–24 months. Univariate analysis revealed bone-invasive growth pattern ( P = 0.007) as a risk factor for headache and intake of antiepileptic drugs ( P = 0.04) or large surrounding oedema ( P

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