Academic literature on the topic 'Paint molecule'

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Journal articles on the topic "Paint molecule"

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Nieves, Daniel, Katharina Gaus, and Matthew Baker. "DNA-Based Super-Resolution Microscopy: DNA-PAINT." Genes 9, no. 12 (2018): 621. http://dx.doi.org/10.3390/genes9120621.

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Super-resolution microscopies, such as single molecule localization microscopy (SMLM), allow the visualization of biomolecules at the nanoscale. The requirement to observe molecules multiple times during an acquisition has pushed the field to explore methods that allow the binding of a fluorophore to a target. This binding is then used to build an image via points accumulation for imaging nanoscale topography (PAINT), which relies on the stochastic binding of a fluorescent ligand instead of the stochastic photo-activation of a permanently bound fluorophore. Recently, systems that use DNA to ac
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Chang, Yeonho, Do-Hyeon Kim, Kai Zhou, et al. "Improved resolution in single-molecule localization microscopy using QD-PAINT." Experimental & Molecular Medicine 53, no. 3 (2021): 384–92. http://dx.doi.org/10.1038/s12276-021-00572-4.

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AbstractSingle-molecule localization microscopy (SMLM) has allowed the observation of various molecular structures in cells beyond the diffraction limit using organic dyes. In principle, the SMLM resolution depends on the precision of photoswitching fluorophore localization, which is inversely correlated with the square root of the number of photons released from the individual fluorophores. Thus, increasing the photon number by using highly bright fluorophores, such as quantum dots (QDs), can theoretically fundamentally overcome the current resolution limit of SMLM. However, the use of QDs in
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Rout, Tapan K., and Kinshuk Roy. "Case History: Di-Octyl Sebacic Acid in Epoxy Paint Leads to Blistering in a Drum and Barrel Manufacturing Plant." Materials Performance 45, no. 4 (2006): 26–30. https://doi.org/10.5006/mp2006_45_4-26.

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Di-octyl sebacic acid (DOS-A) is used as rust preventive oil on steel sheets. When applied below the maximum level of 75 mg/m2 per side, it is compatible with epoxy paint and does not require any pretreatment of the steel sheets. The incompatibility of DOS-A above this maximum could be caused by weak H-bonding between the acid and epoxy molecule, leading to blistering. The optimum oil level was determined through experimentation to avoid paint failure. It was also observed that a variance in the sheet surface roughness of ±0.4 μm did not appreciably affect paint failure.
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Cao, Xian Long, Hong Da Deng, and Wei Lan. "Study of Pressure Sensitive Coating Using Palladium Octaethylporphyrin as Luminescent Molecule." Advanced Materials Research 143-144 (October 2010): 1002–6. http://dx.doi.org/10.4028/www.scientific.net/amr.143-144.1002.

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Pressure sensitive paint (PSP) has become a useful tool to measure the surface pressure distribution of aerodynamic components replacing conventional pressure taps. For the PSP technique based on the luminescence quenching by oxygen, improvement of its sensitivity is important. In this study, we synthesized palladium octaethylporphyrin (PdOEP) as luminophor and embeded PdOEP in polydimethylsiloxane (PDMS) as polymeric binder to make up of pressure sensitive paints. We used UV/Vis spectrometer and spectrofluorimeter to study the absorption and phosphorescence spectra of PdOEP. In addition, by o
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Nieves, Daniel J., Geva Hilzenrat, Jason Tran, et al. "tagPAINT: covalent labelling of genetically encoded protein tags for DNA-PAINT imaging." Royal Society Open Science 6, no. 12 (2019): 191268. http://dx.doi.org/10.1098/rsos.191268.

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Recently, DNA-PAINT single-molecule localization microscopy (SMLM) has shown great promise for quantitative imaging; however, labelling strategies thus far have relied on multivalent and affinity-based approaches. Here, the covalent labelling of expressed protein tags (SNAP tag and Halo tag) with single DNA-docking strands and application of SMLM via DNA-PAINT is demonstrated. tagPAINT is then used for T-cell receptor signalling proteins at the immune synapse as a proof of principle.
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Dai, Mingjie, Ralf Jungmann, and Peng Yin. "Single-Molecule Digital Imaging with Molecular Resolution using DNA-Paint." Biophysical Journal 108, no. 2 (2015): 477a—478a. http://dx.doi.org/10.1016/j.bpj.2014.11.2610.

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de Fátima Oliveira, Marilei, Marcelo Grassi, André Lazarin Gallina, and Paulo Rogério Pinto Rodrigues. "Development and Characterization of an Alternative Process: Nanoceramic Application to the Treatment of Carbon Steel." Materials Science Forum 805 (September 2014): 143–48. http://dx.doi.org/10.4028/www.scientific.net/msf.805.143.

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Paint durability is directly linked to the efficiency of the substrate pre-treatment system. The objective to treat the carbon steel surface prior to painting is to turn the unstable metal surface into a stable surface one, an inert base to receive the paint. This is the main function of the phosphatization processes, which enables good paint adherence and prevents the development of corrosion processes. The demand for cleaner technologies, with lower residue generation, makes the phosphatization an unappealing method, and in this context the use of nanoceramics is an alternative to phosphate
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Machado Querido, Micaela, Ivo Paulo, Sriram Hariharakrishnan, et al. "Auto-Disinfectant Acrylic Paints Functionalised with Triclosan and Isoborneol—Antibacterial Assessment." Polymers 13, no. 13 (2021): 2197. http://dx.doi.org/10.3390/polym13132197.

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Environmental surface contamination with microorganisms is a serious concern worldwide. Triclosan and isoborneol present good antimicrobial activity. Their immobilisation to paint substrates allows for development of a material that stays effective over a longer time. In this work, we disclosed the preliminary studies to evaluate the antimicrobial activity of the active molecule after being functionalised with isocyanates for further immobilisation on the paint substrate. Overall, the newly developed non-release antimicrobial coating provides an effective way of preventing the spread of diseas
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Deußner-Helfmann, Nina S., Alexander Auer, Maximilian T. Strauss, et al. "Correlative Single-Molecule FRET and DNA-PAINT Imaging." Nano Letters 18, no. 7 (2018): 4626–30. http://dx.doi.org/10.1021/acs.nanolett.8b02185.

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Mustafa, Golam, Sajad Shiekh, Keshav GC, Sanjaya Abeysirigunawardena, and Hamza Balci. "Interrogating accessibility of telomeric sequences with FRET-PAINT: evidence for length-dependent telomere compaction." Nucleic Acids Research 49, no. 6 (2021): 3371–80. http://dx.doi.org/10.1093/nar/gkab067.

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Abstract Single-stranded telomeric overhangs are ∼200 nucleotides long and can form tandem G-quadruplex (GQ) structures, which reduce their accessibility to nucleases and proteins that activate DNA damage response. Whether these tandem GQs further stack to form compact superstructures, which may provide better protection for longer telomeres, is not known. We report single-molecule measurements where the accessibility of 24–144 nucleotide long human telomeric DNA molecules is interrogated by a short PNA molecule that is complementary to a single GGGTTA repeat, as implemented in the FRET-PAINT
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Dissertations / Theses on the topic "Paint molecule"

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Haas, Kalina. "Nanoscale co-organization of AMPAR and Neuroligin probed with single-molecule based microscopy." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22134/document.

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Il est bien admis que la compréhension de la structuration moléculaire à l’intérieur des cellules neuronales est essentielle pour appréhender le fonctionnement du cerveau. Pour cette raison, l’étude de l’organisation des molécules clés neuronales et synaptiques contribue grandement à comprendre le mystère du cerveau. AMPA sont des récepteurs ionotropiques du glutamate jouent le rôle central dans la plasticité synaptique et la transmission synaptique basale dans le système nerveux central. Distribution des récepteurs AMPA sur la membrane neuronale est remarquablement hétérogène. Ils sont organi
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Cregg, R. "Molecular mechanisms of pain." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1386921/.

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Recent scientific discoveries have confirmed a pivotal role for the NaV 1.7 voltage-gated sodium channel in human familial gain-of-function and loss-of-function pain syndromes. NaV 1.7 is comprised of four hexameric transmembrane domains encoded by SCN9A, a gene preferentially expressed in dorsal root and sympathetic ganglion neurons. Gain-of-function lesions in SCN9A lead to the development of primary erythromelalgia (PEM). To date, fourteen PEM mutations have been identified which all map to the first three domains of NaV 1.7. I have identified four SCN9A mutations, two of which map to the f
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Yiannaki, E. "Development of small molecule iminodihydroquinolines as new generation pain therapeutics." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1474712/.

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Acute and chronic pain is a common symptom of many diseases. Therapy is often not effective or is associated with significant adverse effects; the development of novel analgesic drugs with high therapeutic index is an urgent unmet clinical need. Several lines of evidence converge to show that pain is mostly signalled by activity in peripheral unmyelinated (C) or thinly myelinated (Aδ) sensory fibres, called nociceptors. A drug selectively affecting the conduction of nociceptors without interfering with the function of other peripheral nerve fibres (Aα, Aβ, Aγ) or cells in the central nervous s
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Brink, Oscar Franciscus van den. "Molecular changes in egg tempera paint dosimeters as tools to monitor the museum environment." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/60293.

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DEPLANO, ALESSANDRO. "Design, synthesis and SAR of small molecules acting on pain pathways." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266710.

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Pain is a pathological disease that constitutes one of the most important problems of public health. Epidemiological studies showed that about 20% of the Europe population is affected by moderate or chronic pain. This data highlighted the gigantic impact of this problem not only in the suffering people but also in term of costs for public health. The classes of drugs most used today in the treatment of pain are NSAIDs and opioids. Unfortunately, both have important side effects specially when used in chronic treatment. Therefore, the research of new drugs which exploiting new targets t
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Fertleman, Caroline Renee. "Molecular genetic analysis of an inherited disorder of paroxysmal pain and autonomic dysfunction : familial rectal pain." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614125.

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Tang, Qingbo. "Nonopioid actions of dynorphin and neuropathic pain." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/289125.

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The hypothesis of this dissertation is that peripheral nerve injury will elevate dynorphin in the spinal cord, which has a facilitating effect on the nociceptive pathway via a non-opioid mechanism. Two major questions are addressed in this dissertation: how dynorphin is up regulated, and how dynorphin produces a facilitating effect on the nociceptive pathway. The first question was approached by examining the activation of NF-κB, AP-1, CREB, and MAP kinase pathways following nerve injury. These experiments indicate that there was an increase in the activation of NF-κB, AP-1 and CREB. While it
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Sui, Ping. "Molecular Signatures of Neuropathic Pain : Revealing Pain-Related Signaling Processes in Spinal Cord Using Mass Spectrometric Methodologies." Doctoral thesis, Uppsala universitet, Analytisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251334.

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In this thesis, the detection of global proteomics alteration and changes in neuropeptide distribution caused by neuropathic pain in rat spinal cord tissue was the main focus. Neuropathic pain (NP) is a major clinical syndrome caused by disease or dysfunction of the nervous system and often mediated by neuronal networks in the spinal cord. The estimated prevalence of NP is 6-8% in general population. Only in the United States, the indirect cost associated with chronic pain has been estimated to 100 billion dollars each year and NP substantially contributes to this cost. So far, the underlying
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Shaikh, Samiha Salwa. "Investigation into the molecular mechanisms of congenital insensitivity to pain." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/279060.

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Congenital insensitivity to pain (CIP) is an extremely rare inherited disorder characterised by the inability to perceive physical pain from birth, resulting in a number of injuries including self-mutilation, repeated burns and fractures. A number of different genes underlying CIP have been identified over the years and all act principally either to direct development or function of nociceptors. In this dissertation, a number of unrelated families with CIP were recruited and novel missense and splicing mutations in NTRK1, NGF and SCN9A were identified in the cohort. The findings presented in t
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McIntee, Erin. "FORENSIC ANALYSIS OF AUTOMOBILE PAINTS BY ATOMIC AND MOLECULAR SPECTROSCOPIC METHODS AND STATISTICAL DATA ANALYSES." Master's thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3131.

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The analysis of 110 automotive paint samples was conducted for the research presented here. Laser-induced breakdown spectroscopy (LIBS) was the central instrument utilized for analysis although scanning electron microscopy / energy dispersive x-ray spectroscopy (SEM/EDS) and Fourier transform infrared spectroscopy – attenuated total reflection (FTIR-ATR) analyses were also performed. Two separate methods of LIBS analysis of samples were used: a cross sectional analysis and a drill down analysis. SEM/EDS analysis focused on the cross section while FTIR-ATR analysis concentrated on the clea
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Books on the topic "Paint molecule"

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Zhuo, Min, ed. Molecular Pain. Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-75269-3.

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Min, Zhuo, ed. Molecular pain. Higher Education Press, 2007.

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David, Borsook, ed. Molecular neurobiology of pain. IASP Press, 1997.

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N, Wood John, ed. Molecular basis of pain induction. Wiley-Liss, 2000.

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P, Hunt Stephen, and Koltzenburg Martin 1962-, eds. The neurobiology of pain: (molecular and cellular neurobiology). Oxford University Press, 2005.

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Symposium on Pathological Pain: From Molecular to Clinical Aspects (2003 Tsukuba-shi, Japan). Pathological pain: From molecular to clinical aspects. John Wiley, 2004.

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Chadwick, Derek J., and Jamie Goode, eds. Pathological Pain: From Molecular to Clinical Aspects. John Wiley & Sons, Ltd, 2004. http://dx.doi.org/10.1002/0470869127.

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State University College at Buffalo. Dept. of Art Conservation., ed. Molecular changes in egg tempera paint dosimeters as tools to monitor the museum environment. FOM-Institute for Atomic and Molecular Physics, 2001.

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State University College at Buffalo. Dept. of Art Conservation., ed. Molecular studies of asphalt, mummy and Kassel earth pigments: Their characterisation, identification and effect on the drying of traditional oil paint. s.n.], 2004.

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1966-, Malmberg Annika B., and Chaplan Sandra R, eds. Mechanisms and mediators of neuropathic pain. Birkhäuser Verlag, 2002.

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Book chapters on the topic "Paint molecule"

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Iwanski, Malina K., Eugene A. Katrukha, and Lukas C. Kapitein. "Lattice Light-Sheet Motor-PAINT: A Method to Map the Orientations of Microtubules in Complex Three-Dimensional Arrays." In Single Molecule Analysis. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3377-9_8.

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AbstractMicrotubules play an essential role in many cellular functions, in part by serving as tracks for intracellular transport by kinesin and dynein. The ability of microtubules to fulfill this role fundamentally depends on the fact that they are polar, with motors moving along them toward either their plus or minus end. Given that the microtubule cytoskeleton adopts a variety of specialized architectures in different cell types, it is important to map precisely how microtubules are oriented and organized in these cells. To this end, motor-PAINT has been developed, but in its current impleme
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Canavero, Sergio, and Vincenzo Bonicalzi. "Sundry Molecules." In Central Pain Syndrome. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-56765-5_18.

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De Koninck, Yves. "Plasticity of Inhibition; GABA/glycine System." In Molecular Pain. Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-75269-3_14.

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Weber, Georg F. "Pain Management." In Molecular Therapies of Cancer. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-13278-5_18.

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Chaudhary, Priya, and Kim Burchiel. "Molecular Mediators of Pain." In Progress in Neurological Surgery. KARGER, 2005. http://dx.doi.org/10.1159/000084468.

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Laslett, Laura L., and Graeme Jones. "Capsaicin for Osteoarthritis Pain." In Capsaicin as a Therapeutic Molecule. Springer Basel, 2014. http://dx.doi.org/10.1007/978-3-0348-0828-6_11.

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Alstergren, Per. "Molecular Temporomandibular Joint Pain Biomarkers." In Orofacial Pain Biomarkers. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53994-1_7.

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Stein, Christoph. "Pain." In Inflammation - From Molecular and Cellular Mechanisms to the Clinic. Wiley-VCH Verlag GmbH & Co. KGaA, 2017. http://dx.doi.org/10.1002/9783527692156.ch34.

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Briani, C., L. Padua, C. Pazzaglia, and L. Battistin. "Neuropathic Pain." In Handbook of Neurochemistry and Molecular Neurobiology. Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-30377-2_19.

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Abbracchio, Maria P., and Angelo M. Reggiani. "Pain and Nociception." In Neurosciences - From Molecule to Behavior: a university textbook. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-10769-6_21.

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Conference papers on the topic "Paint molecule"

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Darden, Winn, Bob Parker, Naoko Sumi, Isao Kimura, Masakazu Ataku, and Takashige Maekawa. "New Water-Based Fluoropolymer Resins for Ultra-Weatherable Coatings." In Paint and Coatings Expo (PACE) 2009. SSPC, 2009. https://doi.org/10.5006/s2009-00008.

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Abstract Fluoropolymer resins find widespread use as building blocks for ultra-weatherable coatings. Fluoroethylene vinyl ether (FEVE) resins were developed to overcome some of the problems associated with the application of standard fluoropolymer coatings. FEVE resins, which yield topcoats with expected lifetimes exceeding 60 years, can be cured at ambient temperatures for field application, or at elevated temperatures in the shop. In order to allow coating manufacturers to conform to government regulations on solvents, water-based FEVE resins were developed several years ago. The original wa
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O’Donoghue, Mike, Ron Garrett, and V. J. Datta. "Straining at a Gnat and Swallowing a Camel: Safety and Performance Issues with Two - Part Urethane Finish Coats." In Paint and Coatings Expo (PACE) 2006. SSPC, 2006. https://doi.org/10.5006/s2006-00056.

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Abstract An escalating amount of negative press on the tried-and-true polyurethane finish coats has arisen due to concerns with their free-isocyanate content. This paper explores performance aspects of polyurethanes with respect to their UV resistance properties, and safety issues associated with polyurethanes as a function of their precursor isocyanate molecules. A brief exploration is undertaken to ascertain whether or not the perceived assault on polyurethanes is justified when certain non-isocyanate replacement technologies deserve more careful scrutiny. Ironically, could it be that indust
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Bedard, Thomas C., T. David Burleigh, and Joseph Kimler. "Formulated Didecyl Dimethyl Ammonium Bicarbonate/Carbonate (DDABC), a Multi-Metal Corrosion Inhibitor with Relevance to Commercial Surface Preparation and Coatings Technologies." In Paint and Coatings Expo (PACE) 2007. SSPC, 2007. https://doi.org/10.5006/s2007-00009.

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Abstract A new water soluble quaternary ammonium compound, didecyldimethyl-ammonium bicarbonate/carbonate (DDABC), has been evaluated as a corrosion inhibitor via standard electrochemical tests on steel and shown to be highly effective. At the proper dilution, the inhibitor migrates to the metal/solution interface and forms a mono-molecular film on the anodic sites. Preliminary evaluations reported here indicate that DDABC and its phosphate and glycolate anion derivatives also exhibit a remarkable ability to improve the corrosion performance of several commercially relevant coatings including
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O'Donoghue, Mike, and Vijay Datta. "The VOC Odyssey: an Epic Tale of the Green World of Coating Formulators." In Paint and Coatings Expo (PACE) 2010. SSPC, 2010. https://doi.org/10.5006/s2010-00037.

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So there you are in the laboratory, a coatings formulator in the modern age, pondering an exciting challenge in the realm of protective coatings, where a real sense of scientific wonder often prevails. The crucial task at hand? One that's been around in one form or another since the late 1980s to the present. You must address head-on the sometimes perplexing regulatory position of volatile organic compounds (VOCs); produce high-performance coatings that are easy and safe to apply; keep the costs down without detracting from in-service performance; do your stint for the environment in particula
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Shah, Sadiq. "Characterization of Interphases in Corrosion by Ex-Situ FTIR Spectroscopy." In CORROSION 1993. NACE International, 1993. https://doi.org/10.5006/c1993-93361.

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Abstract Various nondestructive sampling techniques for Fourier Transform Infrared (FTIR) spectroscopy are capable of probing the molecular details of corrosion products, and corrosion protective films. Examples of the successful use of various sampling techniques for characterizing amorphous, microcrystalline, oily and polymeric paint interphases are discussed. The unique strengths and limitations of various sampling techniques with respect to the macroscopic structure of the interphases and the molecular details of interest are also explored.
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Son, Seong-Mo, Chul Hwan Lee, Chung Seo Park, and Myoung Ho Ahn. "Crack Resistance Improvement of Inorganic Zinc Rich Paint." In CORROSION 2013. NACE International, 2013. https://doi.org/10.5006/c2013-02415.

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Abstract The internal coating of ships’ cargo tanks is essential to protect steel surfaces against corrosion and to avoid contamination. Inorganic ethyl zinc silicate coatings are proven as one of the successful solutions for corrosion protection, but there are several disadvantages in this coating system. The porous structure is easily contaminated and recommended film thickness is limited due to its low crack resistance. In spite of these drawbacks, inorganic ethyl zinc silicate coatings are generally used for chemical products carriers because of its excellent corrosion resistance. In this
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Procopio, Leo, and Laura Vielhauer. "Balancing Act: Principles of Design and Formulation for Waterborne Acrylic DTM Coatings." In SSPC 2017 Greencoat. SSPC, 2017. https://doi.org/10.5006/s2017-00057.

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Abstract Achieving high performance with waterborne acrylic latex DTM coatings often requires a balancing act to be performed by both the polymer scientist designing the latex polymer and the coating scientist formulating the coating. A successful coating is defined by a set of critical properties while in the paint can, during application, and ultimately in its performance throughout its service life. It is often found, particularly with single component waterborne acrylic latex DTM coatings, that realizing certain combinations of key properties is difficult because the polymer feature or for
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Agarwal, D. C., and Helena Alves. "Applications of Alloy 59 (UNS N06059) and Alloy 31 (UNS N08031) in Mitigating Corrosion Problems in CPI and Petrochemical Industries." In CORROSION 2007. NACE International, 2007. https://doi.org/10.5006/c2007-07186.

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Abstract CPI & Petrochemicals constitute a huge, complex and highly diverse industry which forms an integral part of the US economy. It covers converting various raw materials (about 10 of them), the most important ones being organic in nature such as oil, natural gas and coal whilst others are inorganic in nature such as ores / elements taken from the earth (phosphates, sulfur, potash etc), air (nitrogen, oxygen) and water (chlorine, hydrogen). Conversion of these base materials produce about 300 different “intermediates” which then go into production of about 30.000 plus consumer product
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Hu, Ying S. "Breaking the nanoscale labeling and detection limit using Fab-PAINT (Conference Presentation)." In Single Molecule Spectroscopy and Superresolution Imaging XII, edited by Ingo Gregor, Zygmunt K. Gryczynski, and Felix Koberling. SPIE, 2019. http://dx.doi.org/10.1117/12.2507668.

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Deussner-Helfmann, Nina S., Alexander Auer, Maximilian T. Strauss, et al. "Correlating DNA-PAINT and single-molecule FRET for multiplexed super-resolution imaging." In Single Molecule Spectroscopy and Superresolution Imaging XIII, edited by Ingo Gregor, Rainer Erdmann, and Felix Koberling. SPIE, 2020. http://dx.doi.org/10.1117/12.2550629.

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Reports on the topic "Paint molecule"

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Shaw, Andrew D. Molecular Signatures of Chronic Pain Subtypes. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada581471.

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Adam, Alexandre, Saadane Rezaiguia, Romain Severac, and Michel Bouquey. Incorporation of aminoalcohols to tune the properties of polyurethane systems. Universidad de los Andes, 2024. https://doi.org/10.51573/andes.pps39.gs.ps.1.

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It is common practice to incorporate low molecular weight molecules, known as chain extenders, to enhance the performance of polyurethane (PU) material. They usually increase the phase separation between the soft and hard domains, which has a significant impact on the density of hydrogen bonds. Aminoalcohols, molecules with both hydroxyl and amine functional groups, are important building blocks in the synthesis of pharmaceuticals but are also widely used in cosmetics or paints and coatings. Easily derived from abundant natural sources, such as amino acids, aminoalcohols align with the need fo
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Alwagdani, Abdullah. Review Of mPGES-1 Inhibitors Based On The Benzoxazole And Its Isostere Scaffold For The Treatment Of Inflammatory Diseases. University of Tennessee Health Science Center, 2024. http://dx.doi.org/10.21007/com.lsp.2024.0021.

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The vital role of the prostanoid pathway in inflammation, pain, cancer, Alzheimer’s and many other diseases has attracted the drug discovery community to discover targets for therapeutic development. Although existing non-steroidal anti-inflammatory drugs (NSAIDs) inhibiting cyclooxygenases (COX) are widely used, the side effects of these NSAIDs limit the ling time medication. Microsomal prostaglandin E synthase-1 (mPGES-1) is an attractive target that is overexpressed during inflammations, and it could be a safe alternative to NSAIDs for treating inflammatory diseases.Since the discovery of m
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